Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study. (1/116)

The effect of treatment with danazol was evaluated with respect to expectant management after laparoscopic conservative surgery. All patients conservatively operated at laparoscopy for stage III-IV endometriosis from July 1994 to October 1996 were requested to enter the study. Patients who underwent surgery for recurrent endometriosis were excluded from the study, as well as patients who had taken hormonal therapies before laparoscopy. Informed consent was obtained from 77 women who were randomized after surgery to treatment with danazol 600 mg daily for 3 months (n = 36) or to expectant management (n = 41). All patients were regularly followed up every 6 months for evaluation of fertility, recurrence of pain symptoms and disease. During the follow-up, six (55%) of the 11 infertile women allocated to danazol and eight (50%) of the 16 given no treatment became pregnant (not significant). Moderate/severe pelvic pain recurred during follow-up in seven (23%) of the 31 women with pelvic pain allocated to the danazol group and nine (31%) of the 29 allocated to no treatment; the respective cumulative pain recurrence rates at 12 months were 26 and 34% (log rank test, not significant). Three women (8.3%) treated with danazol and six (15%) who received no treatment had disease recurrence as demonstrated by gynaecological examination and/or pelvic ultrasonography (not significant). Our results do not demonstrate a significant advantage of 3 month danazol therapy after laparoscopic surgery for stage III-IV endometriosis with respect to postoperative expectant management.  (+info)

Low-dose danazol after combined surgical and medical therapy reduces the incidence of pelvic pain in women with moderate and severe endometriosis. (2/116)

The most effective therapy for endometriosis is a matter for debate. The aim of the present randomized study was to evaluate the efficacy of low doses of danazol on recurrence of pelvic pain in patients with moderate or severe endometriosis, who had undergone laparoscopic surgery and 6 months of gonadotrophin-releasing hormone analogue (GnRHa) therapy. After surgery, 28 patients with moderate or severe endometriosis underwent therapy for 6 months with GnRHa i. m. every 4 weeks. They were then randomized into two groups: group A (14 subjects) was treated with 100 mg/day danazol for 6 months; group B (14 subjects, control) did not receive any type of therapy. After 12 months of treatment, group A had a significantly (P < 0.01) lower pain score than group B. There was no significant difference between the groups in oestrogen concentrations, bone mineral density or side-effects. The results suggest that low-dose danazol therapy reduces recurrence of pelvic pain in patients with moderate or severe endometriosis, treated surgically, and has few or no metabolic side-effects.  (+info)

Danazol treatment of idiopathic myelofibrosis with severe anemia. (3/116)

BACKGROUND AND OBJECTIVE: Severe anemia is an important problem in patients with idiopathic myelofibrosis (IM). When other therapeutic measures are unsuccessful or not applicable, 40-50% favorable responses are obtained with androgen therapy. Oxymetholone is the drug usually employed, but good results have also been reported with danazol, although the experience is limited to a few patients. The aim of the present study was to evaluate the effect of danazol on the anemia of IM. DESIGN AND METHODS: Seven out of 22 consecutive IM patients were eligible for danazol treatment because of severe anemia not treatable with (four cases) or refractory to (three cases) other therapies. Danazol (600-800 mg/day) was given orally for six months and thereafter progressively tapered to the minimum effective dose in responding patients or discontinued in non-responders. Complete response was considered cessation of transfusion requirements with normalization of hemoglobin (Hb) values; partial response was defined as a > 30% reduction in transfusional needs or an increase > 10 g/L in the Hb. The effect on platelet counts was also analyzed. RESULTS: One patient splenectomized three years earlier achieved a complete response and three a partial response, giving an overall response rate of 57 %. A significant increase in platelet counts was also observed in three responders. The responses were first seen between three and six months after the start of treatment, which was usually well tolerated. INTERPRETATION AND CONCLUSIONS: Danazol, given at an appropriate dosage for a sufficient time, is an effective treatment for a substantial proportion of IM patients with severe anemia without marked splenomegaly or who have been previously splenectomized.  (+info)

Is endometrial pre-treatment of value in improving the outcome of transcervical resection of the endometrium? (4/116)

The aim of this study was to determine whether or not the use of medical pre-treatment of the endometrium improves the outcome of transcervical resection of the endometrium with regards to long-term operative outcome, histological findings and patient satisfaction. A prospective randomized trial comparing three endometrial pre-treatment agents (danazol, medroxyprogesterone acetate or nafarelin) with no pre-treatment was conducted. The main outcome measures were: (i) thickness of the endometrium and myometrium resected; (ii) histological stage of the endometrium at the time of operation; (iii) the presence or absence of menses and (iv) patient satisfaction 1 year post-operatively. Of the three pre-treatments studied, danazol produced a lower median endometrial thickness than the control, showed the greatest ability to induce atrophy of the endometrial glands and stroma (not statistically significant) and produced the highest rate of amenorrhoea (not different to the control). Danazol and nafarelin produced significantly lower median endometrial thickness than no pre-treatment. There were, however, no significant differences in the rates of amenorrhoea in any of the pre-treatment groups compared with that in the control group. No improvement in clinical outcome or patient satisfaction is conferred by the use of medical pre-treatments if transcervical resection of the endometrium is performed in the proliferative phase of the menstrual cycle.  (+info)

Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. (5/116)

A prospective multicenter trial of 119 children 1 to 18 years of age with newly diagnosed aplastic anemia (AA) was conducted, comparing treatment using antithymocyte globulin (ATG), cyclosporine (CyA), and danazol (DAN) with or without rhG-CSF (400 microg/m(2), day on days 1-90). All children with very severe AA received rhG-CSF (VSAA group, n = 50). The other children were randomized to receive ATG, CyA, DAN, and rhG-CSF (G-CSF+ group, n = 35) or ATG, CyA, and DAN without rhG-CSF (G-CSF- group, n = 34). After 6 months, the hematologic response rate was 71%, 55%, and 77% in the VSAA group, G-CSF+ group, and G-CSF- group, respectively. There was no difference in the incidence of febrile episodes and documented infections between the G-CSF+ and G-CSF- groups. Bone marrow transplantation (BMT) was attempted in 22 patients in whom initial immunosuppressive therapy (IST; n = 18) failed or in whom a relapse occurred after an initial response (n = 4). Nineteen of the 22 patients are alive and well after a median follow-up of 18 months (range, 3 to 66 months) since BMT. The probability of survival at 4 years was 83% +/- 7% in the VSAA group, 91% +/- 5% in the G-CSF+ group, and 93% +/- 6% in the G-CSF- group. Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) developed in one patient in each of the three groups; the overall risk for MDS/AML was 3% +/- 2% at 4 years. Because the results of IST were encouraging, it is suggested that children with AA receive IST as first-line therapy if there is no human leukocyte antigen-matched sibling donor.  (+info)

The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot. (6/116)

BACKGROUND: Endometriosis is defined as an inflammatory condition of the female reproductive tract, a state often associated with infertility and miscarriage. Many exogenously administered factors (treatments) control the disease via as yet unknown pathways. Possible candidate molecules involved in these mechanisms could be the serum-soluble human leukocyte antigens (sHIA) that have been detected in a variety of human body fluids and that are associated with several diseases. AIMS: We here examine how danazol and leuprorelin acetate depot treatments exert their anti-inflammatory action. It is plausible that subtle alterations mediated by these treatments and in relation to sHLA may explain the pathophysiology of endometriosis and provide insights towards new therapeutic protocols. METHODS: Indirect enzyme-linked immunosorbent assay (ELISA), using specific monoclonal antibodies, determined serum-soluble class-I and class-II HLA levels. ELISA readings from treated women were compared with normal healthy subjects. RESULTS: Serum-soluble class-I and class-II HLA levels are statistically significantly lower (P < 0.001) in women with endometriosis than in the control groups. However, danazol but not leuprorelin acetate depot administration augments soluble HLA class I and class II (P < 0.01 and P < 0.001, respectively) to normal levels during the treatment period, an increase that may account for the anti-inflammatory effect and the remission observed. CONCLUSIONS: It is shown that one of the underlying causes of endometriosis may be the lack of both circulating class-I and class-II antigen levels. Danazol administration acts via an induced release of these antigens, whose presence correlates with the degree of the inflammatory alleviation obtained. We thus provide evidence that the inflammatory state of the disease appears to be associated with soluble HLA levels because, 3 months after ceasing therapy, the circulating antigens in the serum return to the same levels that correspond to the pathological condition.  (+info)

Danazol and limb-threatening arterial thrombosis: two case reports. (7/116)

Danazol is a synthetic androgenic steroid used clinically for the treatment of a wide variety of disorders. Although there is no extensive evidence that androgens are thrombogenic in humans, there are case reports of cerebral, coronary, and peripheral arterial thrombosis in young male athletes abusing anabolic-androgenic steroids. There are also two reported cases of arterial and venous thrombotic events attributed to danazol therapy. We report two additional cases of limb-threatening arterial thrombosis in patients undergoing danazol therapy, and suggest the possibility that danazol may be an independent risk factor for arterial thrombosis.  (+info)

Allogeneic stem cell transplantation for Evans syndrome. (8/116)

Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic steroids, vincristine, alkylating agents, or cyclosporine. In a patient with refractory disease, an allogeneic hematopoietic stem cell transplant (HSCT) resulted in complete clinical and serologic remission for more than 30 months. Allogeneic HSCT may be the only current curative therapy for Evans syndrome but may also be complicated by significant toxicities.  (+info)

*Danazol

... is the generic name of the drug and its INN, USAN, USP, BAN, DCF, DCIT, and JAN. Danazol is or has been marketed under ... Danazol has been found to act as an inhibitor of the following steroidogenesis enzymes: Danazol has also been found to be a ... Binding of danazol to SHBG is considered to be more important clinically. By occupying SHBG and transcortin, danazol increases ... Danazol is contraindicated during pregnancy because it has the potential to virilize female fetuses. Women taking danazol ...

*Emergency contraception

"Danazol". Medscape. 2002. Retrieved 2006-11-08. "Contraception: past, present and future". UK Family Planning Association. ... Danazol was tested in the early 1980s in the hopes that it would have fewer side effects than Yuzpe, but was found to be ...

*List of drugs: Cp-Cz

Redirects to Danazol. cyclomenol (INN) cyclomethycaine (INN) Cyclomydril Cyclopar cyclopentamine (INN) cyclopenthiazide (INN) ...

*A. Albert Yuzpe

American journal of …, 1987 Richard P. Dickey, A. Albert Yuzpe (1985). Managing Cyclomen (Danazol) Patients. Jacques-E. Rioux, ...

*Progestin-induced virilisation

In 1991 the FDA required a black box warning that use of danazol in pregnancy is contraindicated because exposure to danazol in ... Brunskill PJ (February 1992). "The effects of fetal exposure to danazol". Br J Obstet Gynaecol. 99 (3): 212-5. doi:10.1111/j. ... The black box warning recommends a sensitive hCG-beta-subunit pregnancy test immediately prior to starting danazol therapy and ... No genital anomalies were reported where danazol therapy was discontinued before the 8th week of pregnancy. The warnings ...

*Luteolysis

Danazol was described as a luteolytic agent. Cloprostenol is another example of such an agent. Wentz AC, Sapp KC. Danazol as a ...

*Steroid sulfatase

Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol". Acta ... Inhibitors of STS include irosustat, estrone sulfamate (EMATE), estradiol sulfamate (E2MATE), and danazol. Steroidogenic enzyme ...

*Steroidogenesis inhibitor

Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol". Acta ... Steroid sulfatase (STS) inhibitors such as estradiol sulfamate, estrone sulfamate, irosustat, and danazol inhibit the ...

*Robert Benjamin Greenblatt

He also showed that the drug Danazol was useful in the management of endometriosis and fibrocystic breast disease. Greenblatt's ... Greenblatt, R., & Ben-Nunn, I. (1980). Danazol in the Treatment of Mammary Dysplasia. Drugs(19), 349-355. Greenblatt, R., ... Greenblatt , R., & Tzingounis, V. (1979). Danazol Treatment of Endometriosis: Long-term Follow Up. Fertility and Sterility, 32 ... Mahesh, V., & Dmowski, P., Scholoer, H. (1969). Danazol - A Synthetic Steroid Derivative with Interesting Physiologic ...

*Cholinergic urticaria

La Shell, M. S.; England, R. W. (2006). "Severe refractory cholinergic urticaria treated with danazol". Journal of drugs in ... Treatment(s) with mixed success: omalizumab (anti-IgE therapy), danazol (synthetic androgen), propranolol (beta blocker), ...

*Simvastatin

... or the endometriosis drug danazol. Reduced maximum doses of simvastatin apply for patients taking certain other drugs, ...

*Breast pain

Danazol, an estrogen biosynthesis inhibitor, tamoxifen, an antagonistic modulator of the estrogen receptor, and bromocriptine, ... For anti hormonal treatment, danazol (Danocrine) can be helpful. Tamoxifen citrate is used in some cases of severe breast pain ...

*Gestrinone

Unlike danazol, gestrinone does not appear to bind to SHBG or corticosteroid-binding globulin (CBG). Gestrinone is well- ... Gestrinone is described as similar in action and effect to danazol, which is also used in the treatment of endometriosis, but ... Similarly to danazol, gestrinone acts as a weak antigonadotropin via activation of the PR and AR in the pituitary gland and ... "A multicentre comparative study of gestrinone and danazol in the treatment of endometriosis". Journal of Obstetrics and ...

*Evans syndrome

1993). "[Effective danazol therapy for a patient with Evans syndrome]". Rinsho Ketsueki (in Japanese). 34 (2): 143-6. PMID ... vincristine and danazol) are subsequently used, or combinations of these. The off-label use of rituximab (trade name Rituxan) ...

*Penicillamine

"Successful treatment of D-penicillamine-induced breast gigantism with danazol". Br Med J. 282: 362-3. doi:10.1136/bmj.282.6261. ...

*Isoxazole

Examples of AAS containing the isoxazole ring include danazol & androisoxazole. Oxazole, an analog with the nitrogen atom in ...

*Endometriosis

... but were no more effective than danazol or intrauterine progestagen, and had more side effects than danazol. Aromatase ... Danazol (danocrine) and gestrinone are suppressive steroids with some androgenic activity. Both agents inhibit the growth of ... danazol and gonadotropin-releasing hormone agonists. However, many of these agents are associated with undesirable side effects ...

*Uterine fibroid

Danazol is an effective treatment to shrink fibroids and control symptoms. Its use is limited by unpleasant side effects. ...

*Aquagenic urticaria

Wong, E; Eftekhari, N; Greaves, M. W.; Ward, A. M. (1987). "Beneficial effects of danazol on symptoms and laboratory changes in ...

*Jenny Higham

Jennifer, Higham (1993). "The clinical evaluation of unexplained menorrhagia and its treatment with danazol and norethisterone ...

*Ovarian remnant syndrome

Medications may be used to treat ORS and include GnRH agonists, danazol, or progesterone. The incidence of ovarian remnant ...

*Gliclazide

Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, or β-2 agonists. Its hypoglycemic ...

*Simvastatin/sitagliptin

Juvisync should not be used with: strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozil, and other fibrates. Caution ...

*Warm antibody autoimmune hemolytic anemia

If refractory to both these therapies, other options include rituximab, danazol, cyclosphosphamide, azathioprine, or ...
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There is scarce information about the effects of danazol and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of danazol at the cardiovascular level is very confusing. In order to clarify those phenomena in this study, a danazol derivative was synthesized with the objective of evaluating its activity on perfusion pressure and coronary resistance and comparing this phenomenon with the effect exerted by danazol. The Langendorff technique was used to measure changes on perfusion pressure and coronary resistance in an isolated rat heart model in the absence or presence of danazol and its derivative. Additionally, to characterize the molecular mechanism involved in the inotropic activity induced by danazol derivative was evaluated by measuring left ventricular pressure in the absence or presence of following compounds; flutamide, prazosin, metoprolol, indomethacin and nifedipine. The results showed that danazol derivative significantly increased the
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Immune thrombocytopenia (ITP) is a severe bleeding disorder. Approximately 2/3 of patients achieve remission from first-line therapies. However, the underlying mechanism of corticosteroid-resistant or relapsed ITP is not well understood; thus, treatment remains a great challenge. Atorvastatin was shown to enhance bone marrow endothelial cell function and N-acetylcysteine (NAC) was shown to inhibit PLT binding to endothelial cell.. A multicentre prospective study was performed in non-splenectomized ITP patients who were either resistant to a standard dose of corticosteroids or had relapsed. Patients were randomized to atorvastatin, acetylcysteine plus danazol with danazol monotherapy group. Platelet count, bleeding and other symptoms were evaluated before and after treatment. Adverse events are also recorded throughout the study, in order to compare the efficacy and safety of atorvastatin, acetylcysteine plus danazol with danazol monotherapy in patients with corticosteroid-resistant/relapsed ITP. ...
In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor.. If you miss a dose of danazol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.. DOSAGE. The dose of danazol will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of danazol. If your dose is different, do not change it unless your doctor tells you to do so ...
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Danazol is known to bind to two steroid hormone carrier proteins: sex hormone-binding globulin (SHBG), which binds androgens and estrogens; and corticosteroid-binding globulin (CBG), which binds progesterone and cortisol.[5][6] Binding of danazol to SHBG is considered to be more important clinically.[6] By occupying SHBG and CBG, danazol increases the ratio of free to plasma protein-bound testosterone, estradiol, progesterone, and cortisol.[5][6] The table to the right shows the difference in testosterone levels in premenopausal women treated with danazol.[6] As can be seen, the percentage of free testosterone is tripled in women being treated with danazol.[6][34] The ability of danazol to increase free testosterone levels suggests that a portion of its weak androgenic effects are mediated indirectly by facilitating the activity of testosterone and dihydrotestosterone through the displacement of them from SHBG.[6][34] In addition to binding to and occupying SHBG however, danazol also decreases ...
I am a 42 years old female, with a 23 years old daughter. Due to very heavy and painful periods, my haemoglobin had fallen to 6.5. I was given a course of 10 jectofer injections two months ago. When an ultrasound revealed 2 endometriotic cysts in each ovary and a polyp in uterus, I was operated laparoscopically last month. The cysts were drained and polyps were also removed vaginally. Now I have been put on Gonablock (Danazol) Tablets- 100 mg twice a day for 3 months to prevent recurrence of cysts. I have a history of duodenal ulcer and am taking Pantocid DSR for past 3 years and Gelusil and Alprax for past 10 years. I am continuing these to counter side effects of Danazol, as told by my doctor. I have been taking Danazol for 20 days now. |b|The other side effects have more or less stabilised but I am worried that my voice may crack or become hoarse.|/b| I am in a PR job. Please tell me when is it likely to happen i.e. how long after starting the course can this side effect develop? Is the long term use
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Methods: The present cross sectional study was conducted in the department of obstetrics and gynecology SN Medical College Agra. Over the period from December 2010 to November 2013. Symptomatic women (n=50) of age group 20-39 yrs coming to gynecology OPD were selected for study group. The study group was subjected to detailed history, physical examination laboratory test, ultrasound examination, and laparoscopy. Then 50 patients were allotted for laparoscopic fulguration and 50 for danazol treatment ...
Danazol is a derivative of the synthetic steroid ethisterone that suppresses the production of gonadotropins and has some weak androgenic effects. Before becoming available as a generic drug, danazol was marketed as Danocrine in the United States. It was approved by the US Food and Drug Administration (FDA) as the first drug to specifically treat endometriosis in the early 1970s. Although effective for endometriosis, its use is limited by its masculinizing side-effects. Its role as a treatment for endometriosis has been largely replaced by the GnRH agonists.
Danazol - Danazol is used in the treatment of endometriosis and fibrocystic breast disease, and for the prevention of attacks of angioedema.
... Danazol is used to treat endometriosis, fibrocystic breast disease and to prevent attacks of angioedema.
How Danazol works It is thought that Danazol eradicates endometrial implants in several ways. The net result is that the production of oestrogen is suppressed
The following events have been reported in association with the use of danazol:. Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare.. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with danazol, persistent amenorrhea has occasionally been reported.. Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen. Nervousness and emotional lability have been reported. In the male a modest reduction in spermatogenesis may be evident during treatment. Abnormalities in semen volume, viscosity, sperm count, and motility ...
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DANAZOL lowers the liver s output of SHBG, but, TT also drops, thus making the stand alone use of DANAZOL (to raise FT) futile. Shawn, you have access
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Danazol is a synthetic steroid hormone used in treatment of endometriosis, fibrocystic breast disease, benign breast tumors, abnormally long periods, premenstrual syndrome, gynecomastia.
Product name: Danocrine. Active ingredient: Danazol. Thumbnail sketch: Generic Danocrine affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. It is used to treat endometriosis and fibrocystic breast disease. It is also used to prevent attacks of angioedema in people with an inherited form of this disorder.. Also Known As: Danogen / Gynazol / Danocrine. Manufacturer: Cipla / Sun Pharma. Where to buy: Go to product page. Payment method: Visa. Delivery Time: 5-7 business days by Courier Service or 10-21 business days by Standard International Airmail. Loyalty Program: FREE pills! FREE shipping! Discounts! (up to 10%) & more.... ...
Main / Syringes with Needles / Danazol lupus thrombocytopenia These include down-regulation of autoantibody production, neutralization of pathogenic autoantibodies by anti-idiotypic antibodies, inhibition of complement-mediated damage, modulation of cytokine production, induction of apoptosis in lymphocytes and monocytes, and modulation of both B- and T-lymphocyte function [ 69 ].. Scand J Haematol ; A number of novel therapeutic approaches to the management of cytopenias, including thrombopoeitin receptor agonists and anti-B-cell therapies, in particular, are showing great promise. Human parvovirus B19 infection during the inactive stage of systemic lupus erythematosus. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.. Given the important role for the spleen in the clearance of immune complexes, a risk of a flare in disease activity has been suggested following splenectomy in SLE [ 35 ], but this is not generally born out in practice. Of the remaining ...
To the editor: Sex hormones appear to influence the immune system; for example, after immunization, women have higher immunoglobulin levels and a greater capacity for producing antibodies than men (1). The sex hormone modulation of cellular immune responses may be of pathophysiologic and perhaps therapeutic importance, because in the NZB/NZW/BFI mouse lupus model, castration of the male accelerates the disease and administration of estrogens to the castrated males accelerates the disease still further (2). Recently, we reported the presence of androgen receptors in 13 biopsy specimens of non-Hodgkins malignant lymphomas (3). Because danazol is an impeded androgen and antiestrogen with ...
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Results from a continuing clinical trial in benign breast disease indicate that danazol may induce progesterone receptors and that this effect persists after treatment. In women given danazol the number of biopsy specimens that were positive for progesterone receptors rose from 14 out of 31 before treatment to 23 out of 30 at the end of six months treatment and remained raised at 21 out of 31 six months later. The number of biopsy specimens that were positive for oestrogen receptors rose transiently from eight out of 31 to 12 out of 30 and then fell to six out of 31. A satisfactory clinical response was achieved in 26 of the 31 patients but was maintained in only 11 six months or more after the end of treatment. It was only in this group that a significant and long-standing increase in progesterone receptors was observed. These findings suggest that in some women with benign breast disease who have been treated with danazol changes occur that may have long term benefit. ...
Kőhalmi, Kinga Viktória and Veszeli, Nóra and Luczay, Andrea and Varga, Lilian and Farkas, Henriette (2017) A danazolkezelés hatása C1-inhibitor-hiány okozta hereditaer angiooedemás gyermekek növekedésére , Effect of danazol treatment on growth in pediatric patients with hereditary angioedema due to C1-inhibitor deficiency. Orvosi Hetilap, 158 (32). pp. 1269-1276. ISSN 0030-6002 Csuka, Dorottya and Veszeli, Nóra and Varga, Lilian and Prohászka, Zoltán and Farkas, Henriette (2017) The role of the complement system in hereditary angioedema. Molecular Immunology, 89. pp. 59-68. ISSN 0161-5890 Horváth, Zsófia and Csuka, Dorottya and Vargova, Katarina and Kovács, Andrea and Lee, Sarolta and Varga, Lilian and Prohászka, Zoltán and Kiss, Róbert Gábor and Préda, István and Tóth Zsámboki, Emese (2016) Alternative complement pathway activation during invasive coronary procedures in acute myocardial infarction and stable angina pectoris. CLINICA CHIMICA ACTA, 463. pp. 138-144. ISSN ...
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.
Quarante et un essais (n = 4935 femmes) ont été inclus. Les données suggèrent que les analogues de la GnRH ont été plus efficaces pour le soulagement des symptômes que labsence de traitement/un placebo. Aucune différence statistiquement significative na été rapportée entre les analogues de la GnRH et le danazol pour la dysménorrhée RR = 0,98 (IC à 95 % de 0,92 à 1,04 ; P = 0,53). En dautres termes, cela correspond à 3 femmes pour 1000 de moins (IC à 95 % de 12 à 6) qui présentent un soulagement de la douleur symptomatique dans le groupe traité par analogue de la GnRH. Les événements indésirables signalés se sont avérés plus nombreux dans le groupe traité par analogue de la GnRH. Pour la résolution globale, il a été observé un effet bénéfique en faveur des analogues de la GnRH, RR = 1,10 (IC à 95 % de 1,01 à 1,21 ; P = 0,03) comparativement au danazol. Aucune différence statistiquement significative na été observée en termes de douleur globale entre les ...
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Mastalgia is a common but often poorly understood condition with little Australian data available on the subject. Details are presented of 170 patients who have attended a specific mastalgia clinic at the Princess Alexandra Hospital, Brisbane, Queensland, over a 3 year period. The aims and management protocol of the clinic are outlined. The mastalgia sufferer in this study had an average age of 42 years and 87% were multiparous. Cyclical pain occurred in 59% as determined by a daily pain record chart. Unilateral pain occurred in 38%. Lack of previous breast feeding and low levels of regular physical exercise were identified as two significant factors in the history of those attending the clinic. The responses to treatments are outlined. Response rates of 18 and 26% to two commonly used natural products, Vitamin B6 and Evening Primrose Oil, respectively, are considered little better than placebo effect. A complete response was achieved in 67% of women who took low dose danazol with minimal side ...
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To the Editor: Danazol was initially used for inhibition of the pituitary-ovarian axis and treatment of angioedema due to deficiency of C1 esterase inhibitor. Side effects are generally related to hormonal changes and fluid retention. Hypersensitivity reactions are not prominent. Danazol has recently been used as a therapeutic agent in some autoimmune diseases such as idiopathic thrombocytopenia and autoimmune hemolytic anemia (1-3). We report the cases of two patients who developed erythema multiforme while receiving danazol (Danocrine; Winthrop-Breon, New York, New York).. A 49-year-old man had profuse bleeding from lacerations due to a motor vehicle accident. His platelet count was ...
Danazol and benign intracranial hypertension. Shah, Ajay; Roberts, Tim; McQueen, I.N.F.; Graham, J.G.; Walker, Kate // British Medical Journal (Clinical Research Edition);5/23/1987, Vol. 294 Issue 6583, p1323 Focuses on the benign intracranial hypertension in patients treated with danazol. Three case reports on danazol prescription; Detection of abnormalities after taking danazol; Comment on danazol treatment on patient with benign intracranial hypertension. ...
A Phase 2 Pilot Trial of Ruxolitinib combined with Danazol for Patients with Primary Myelofibrosis (MF), Post Essential Thrombocythemia-Myelofibrosis (Post ET) and Post Polycythemia Vera Myelofibrosis (PV MF) Suffering from Anemia
To the Editor: Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is characterized by recurrent bleeding episodes, multiple telangiectasias, and familial occurrence. Treatment of this disease is unsatisfactory. Oral estrogen may be very useful in controlling the frequency and severity of epistaxis (1). However, due to the feminizing effects of estrogens, male patients may be reluctant to take the hormones. The authors were recently forced to search for an alternative treatment in a male patient who refused to take estrogen. There was marked improvement of symptoms with danazol, a synthetic weak androgen.. A 41-year-old white army veteran had severe anemia; he had a ...
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A synthetic steroid with antigonadotropic and antiestrogenic activity due to the suppression of the pituitary glands gonadotropic hormone and with androgenic effects (Sanofi 2017, AEMPS 2017). Used to treat endometriosis, fibrocystic breast disease, hereditary angioedema, mastalgia, premenstrual syndrome and menorrhagia. Administration orally twice a day. Since the last update we have not found published data on its excretion in breastmilk or its effect on breastfed infants (Briggs 2017). In the absence of data regarding protein binding and the volume of distribution, the known pharmacokinetic data (low molecular weight, high pKa and prolonged half-life) make it likely that it would transfer to milk in amounts which could be significant. Due to its possible androgenic effect on the infant and inhibition of prolactin, it should be avoided during breastfeeding (Hale 2019 p193, Sanofi 2017, AEMPS 2017).
Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. Also known as 17alpha-ethinyl testosterone. Before becoming available as a generic drug, Danazol was marketed as Danocrine in the United States. It was approved by the U.S. Food and Drug Administration (FDA) as the first drug to specifically treat endometriosis in the early 1970s. Although effective for endometriosis, its use is limited by its masculinizing side-effects.Its role as a treatment for endometriosis has been largely replaced by the GnRH agonists.. ...
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Other ways to relieve symptoms include applications of heat on your abdominal area and mild forms of exercise.. Danazol (Danocrine) is a synthetic drug that resembles a male hormone, and is sometimes used to reduce severe menstrual cramps, menorrhagia, fibroids and symptoms of endometriosis. Occasionally, it is used in conjunction with an oral contraceptive. The drug works by suppressing menstruation and estrogen levels. Side effects may include facial hair, deepening of the voice, weight gain, acne, dandruff and elevated cholesterol levels. Pregnant women and those seeking to become pregnant are not advised to take this medication due to potential risk of birth abnormalities.. ...
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Androgens that may be used include: Danazol (Danacrine®) Fluoxymestrone (Halotestin®) Oxymetholone Stanazolol (Winstrol®) Testosterone
Stanozolol is perhaps the only drug (except, danazol), which is able to interact with androgen receptors in the microsomal level (that is, with the androgen receptors located inside the
Urticaria cholinergic is another type of the Urticaria that is caused by a certain physical stimulus of some or of the other class. It is classified like physical urticaria, meaning that is caused by a physical stimulus of a certain class. The physical stimulus could be indicated as heat although the real cause is defined as sweating. The study of the activity of the cell of the mast includes Urticaria generally cholinergic because most of the cases of Urticaria cholinergic looks like to critically imply the cells of the mast. The main mediator is the histamina of the serum, that rises in the concentration when an induced test exercise is introduced. This treatment also implies quimiotácticos factors eosinophil and of the neutrophil as well as it tryptase. The levels of the alpha 1-antichymotrypsin diminish, and the use of danazol gives rise to the improvement in the eruption. Due to these results, some have discussed in please proteases like a cause of the histamina that was sent. The skin ...
Here a primary cardiac cell line was examined for its potential use to screen for cardiac metabolism-related liabilities. These ventricular cells are derived from adult humans, which is important considering the interspecies differences in CYP2J activity previously reported (Ma et al., 2004; Yamasaki et al., 2004; Aiba et al., 2006; Elshenawy et al., 2013). Further, much of the drug-induced cardiotoxicity can be attributed to ventricular tissue. The P450 mRNA expression profile was similar to human cardiac ventricular tissue, with CYP2J2 by far the dominant isoform. The ability of the cells to metabolize CYP2J2 substrates astemizole and terfenadine was also established. Various compounds most notably danazol and ketoconazole readily inhibited CYP2J2 activity. However, CYP2J2 mRNA were mostly unchanged in the presence of potential inducers.. Others have shown the dominant presence of CYP2J2 in cardiac tissue, using immunoblotting or quantitative real-time PCR (Wu et al., 1996; Michaud et al., ...
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Zotter, Zsuzsanna and Nagy, Zsolt and Patócs, Attila Balázs and Csuka, Dorottya and Veszeli, Nóra and Kőhalmi, Kinga Viktória and Farkas, Henriette (2017) Glucocorticoid receptor gene polymorphisms in hereditary angioedema with C1-inhibitor deficiency. Orphanet Journal of Rare Diseases, 12 (1). pp. 1-8. ISSN 1750-1172 Kőhalmi, Kinga Viktória and Veszeli, Nóra and Luczay, Andrea and Varga, Lilian and Farkas, Henriette (2017) A danazolkezelés hatása C1-inhibitor-hiány okozta hereditaer angiooedemás gyermekek növekedésére , Effect of danazol treatment on growth in pediatric patients with hereditary angioedema due to C1-inhibitor deficiency. Orvosi Hetilap, 158 (32). pp. 1269-1276. ISSN 0030-6002 Csuka, Dorottya and Veszeli, Nóra and Varga, Lilian and Prohászka, Zoltán and Farkas, Henriette (2017) The role of the complement system in hereditary angioedema. Molecular Immunology, 89. pp. 59-68. ISSN 0161-5890 Kajdácsi, Erika and Jani, Péter K. and Csuka, Dorottya and Varga, Lilian ...
BACKGROUND: Eltrombopag is an oral, non-peptide, thrombopoietin-receptor agonist that stimulates thrombopoiesis, leading to increased platelet production. This study assessed the efficacy, safety, and tolerability of once daily eltrombopag 50 mg, and explored the efficacy of a dose increase to 75 mg. METHODS: In this phase III, randomised, double-blind, placebo-controlled study, adults from 63 sites in 23 countries with chronic idiopathic thrombocytopenic purpura (ITP), platelet counts less than 30 000 per muL of blood, and one or more previous ITP treatment received standard care plus once-daily eltrombopag 50 mg (n=76) or placebo (n=38) for up to 6 weeks. Patients were randomly assigned in a 2:1 ratio of eltrombopag:placebo by a validated randomisation system. After 3 weeks, patients with platelet counts less than 50 000 per microL could increase study drug to 75 mg. The primary endpoint was the proportion of patients achieving platelet counts 50 000 per microL or more at day 43. All participants who
Idiopathic Thrombocytopenic Purpura - MedHelps Idiopathic Thrombocytopenic Purpura Center for Information, Symptoms, Resources, Treatments and Tools for Idiopathic Thrombocytopenic Purpura. Find Idiopathic Thrombocytopenic Purpura information, treatments for Idiopathic Thrombocytopenic Purpura and Idiopathic Thrombocytopenic Purpura symptoms.
We read with interest the letter by Emilla et al.1 describing long-term results of low dose cyclosporine in idiopathic thrombocytopenic purpura (ITP). It would have been interesting to know in how many patients was cyclosporine used so that the overall response rates could be known. There are anecdotal reports using Cyclosporin for chronic ITP with various doses.1-7 The overall response to cyclosporine was found in 40-55% of patients. Many patients remained dependent on cyclosporine. We would like to share our experience of therapy with cyclosporine in a large cohort of patients with chronic ITP in both adults and children.. Patients and method: This study is a prospective study of chronic ITP patients treated with cyclosporine at our centre from July 2004 to December 2005. The diagnosis of ITP was based on the presence of thrombocytopenia with normal or increased megakaryocytes in a morphologically normal marrow. Inclusion criteria were: Patients with platelet counts , 30,000/uL or more if they ...
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Diagnosis and symptomatic therapy of Idiopathic thrombocytopenic purpura with corticosteroids und transfusion therapy (costs for program #182707) ✔ University Hospital Marburg UKGM ✔ Department of Pediatric and Adolescent Medicine ✔ BookingHealth.com
Immune thrombocytopenic purpura (ITP) in adults is a chronic autoimmune disease characterized by antiplatelet antibody (APA)-mediated thrombocytopenia. 1

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  • Danazol has a complex mechanism of action , and is characterized as a weak androgen and anabolic steroid , a weak progestogen , a weak antigonadotropin , a weak steroidogenesis inhibitor , and a functional antiestrogen . (wikipedia.org)
  • In addition, to date the cellular site and mechanism of action of danazol at the cardiovascular level is very confusing. (scirp.org)
  • Danazol, USP is a synthetic steroid derived from ethisterone. (nih.gov)
  • This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors. (nih.gov)
  • The steroid hormone receptor activity profile of danazol is as follows: As such, danazol is described as a possessing high affinity for the AR, moderate affinity for the PR and GR, and poor affinity for the ER. (wikipedia.org)
  • A dosage of 800 mg/day danazol was found to increase telomere length in patients with telomere diseases in a phase I/II clinical trial. (wikipedia.org)
  • Although in contradiction with the above data, another study found that danazol weakly inhibited aromatase as well, with 44% inhibition at a concentration of 10 μM. (wikipedia.org)
  • Although the affinity and efficacy of danazol itself at the PR are relatively low, ethisterone, one of the major metabolites of danazol, is described as a weak progestogen (and has been employed clinically as a progestogenic contraceptive), and this presumably balances the in vivo progestogenic activity of danazol. (wikipedia.org)
  • Danazol, like most other anabolic steroids, has been linked with an increased risk of liver tumors . (wikipedia.org)
  • Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of danazol to receptors of gonadal steroids at target organs. (nih.gov)
  • Now I have been put on Gonablock (Danazol) Tablets- 100 mg twice a day for 3 months to prevent recurrence of cysts. (ndtv.com)
  • As a result of the demand for danazol and its added benefits the expense for this medication is a little more than some of its competitors like clomid or Nolvadex . (anabolika.de)
  • Androgenic side effects are of concern, as some women taking danazol may experience unwanted hair growth ( hirsutism ), acne , irreversible deepening of the voice , or adverse blood lipid profiles . (wikipedia.org)
  • T he Lan gendorff technique was used to measure changes on perfusion pressure and coronary resistance in an isolated rat heart model in the absence or presence of danazol and its derivative. (scirp.org)
  • Single-arm, open-lable, multicentre study to compare the efficacy and safety of atorvastatin, acetylcysteine plus danazol with danazol monotherapy in patients with corticosteroidresistant/relapsed ITP. (clinicaltrials.gov)
  • Adverse events are also recorded throughout the study, in order to compare the efficacy and safety of atorvastatin, acetylcysteine plus danazol with danazol monotherapy in patients with corticosteroid-resistant/relapsed ITP. (clinicaltrials.gov)
  • Since danazol is metabolized by the liver , it cannot be used by patients with liver disease , and in patients receiving long-term therapy, liver function must be monitored on a periodic basis. (wikipedia.org)
  • Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with danazol is discontinued. (nih.gov)
  • Danazol can still continue to be used to prevent estrogenic problems in a post cycle therapy. (anabolika.de)
  • Danazol can offer some greater benefits than a traditional estrogen blocker as it helps to boost LH hormones during post cycle therapy. (anabolika.de)
  • The use of danazol is limited by masculinizing side effects such as acne , excessive hair growth , and voice deepening . (wikipedia.org)
  • Due to its side effects, danazol is seldom prescribed continuously beyond six months. (wikipedia.org)
  • I am continuing these to counter side effects of Danazol, as told by my doctor. (ndtv.com)
  • While many bodybuilders do not experience any type of gynecomastia side effects, introducing an estrogen blockers such as danazol can ensure that there is a minimal risk of these side effects from occurring. (anabolika.de)
  • Some patients who use danazol experience weight gain and fluid retention . (wikipedia.org)
  • Although not currently a standard treatment for menorrhagia, danazol demonstrated significant relief in young women with menorrhagia in a study, and, because of a lack of a significant adverse effects, it was proposed as an alternative treatment. (wikipedia.org)
  • Danazol can regulate hormones throughout the body and change the way that the ovaries produce their hormones. (anabolika.de)
  • Women taking danazol should practice effective contraception to prevent pregnancy if sexually active . (wikipedia.org)
  • The activity of danazol at the ER is considered to be minimal, although at very high concentrations the drug can act significantly as an ER agonist. (wikipedia.org)
  • Danazol is considered to act significantly as an agonist of the GR, and thus, as a glucocorticoid. (wikipedia.org)
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