A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Pregnane derivatives containing two double bonds anywhere within the ring structures.
17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.
A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.
Excessive uterine bleeding during MENSTRUATION.
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.

Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study. (1/116)

The effect of treatment with danazol was evaluated with respect to expectant management after laparoscopic conservative surgery. All patients conservatively operated at laparoscopy for stage III-IV endometriosis from July 1994 to October 1996 were requested to enter the study. Patients who underwent surgery for recurrent endometriosis were excluded from the study, as well as patients who had taken hormonal therapies before laparoscopy. Informed consent was obtained from 77 women who were randomized after surgery to treatment with danazol 600 mg daily for 3 months (n = 36) or to expectant management (n = 41). All patients were regularly followed up every 6 months for evaluation of fertility, recurrence of pain symptoms and disease. During the follow-up, six (55%) of the 11 infertile women allocated to danazol and eight (50%) of the 16 given no treatment became pregnant (not significant). Moderate/severe pelvic pain recurred during follow-up in seven (23%) of the 31 women with pelvic pain allocated to the danazol group and nine (31%) of the 29 allocated to no treatment; the respective cumulative pain recurrence rates at 12 months were 26 and 34% (log rank test, not significant). Three women (8.3%) treated with danazol and six (15%) who received no treatment had disease recurrence as demonstrated by gynaecological examination and/or pelvic ultrasonography (not significant). Our results do not demonstrate a significant advantage of 3 month danazol therapy after laparoscopic surgery for stage III-IV endometriosis with respect to postoperative expectant management.  (+info)

Low-dose danazol after combined surgical and medical therapy reduces the incidence of pelvic pain in women with moderate and severe endometriosis. (2/116)

The most effective therapy for endometriosis is a matter for debate. The aim of the present randomized study was to evaluate the efficacy of low doses of danazol on recurrence of pelvic pain in patients with moderate or severe endometriosis, who had undergone laparoscopic surgery and 6 months of gonadotrophin-releasing hormone analogue (GnRHa) therapy. After surgery, 28 patients with moderate or severe endometriosis underwent therapy for 6 months with GnRHa i. m. every 4 weeks. They were then randomized into two groups: group A (14 subjects) was treated with 100 mg/day danazol for 6 months; group B (14 subjects, control) did not receive any type of therapy. After 12 months of treatment, group A had a significantly (P < 0.01) lower pain score than group B. There was no significant difference between the groups in oestrogen concentrations, bone mineral density or side-effects. The results suggest that low-dose danazol therapy reduces recurrence of pelvic pain in patients with moderate or severe endometriosis, treated surgically, and has few or no metabolic side-effects.  (+info)

Danazol treatment of idiopathic myelofibrosis with severe anemia. (3/116)

BACKGROUND AND OBJECTIVE: Severe anemia is an important problem in patients with idiopathic myelofibrosis (IM). When other therapeutic measures are unsuccessful or not applicable, 40-50% favorable responses are obtained with androgen therapy. Oxymetholone is the drug usually employed, but good results have also been reported with danazol, although the experience is limited to a few patients. The aim of the present study was to evaluate the effect of danazol on the anemia of IM. DESIGN AND METHODS: Seven out of 22 consecutive IM patients were eligible for danazol treatment because of severe anemia not treatable with (four cases) or refractory to (three cases) other therapies. Danazol (600-800 mg/day) was given orally for six months and thereafter progressively tapered to the minimum effective dose in responding patients or discontinued in non-responders. Complete response was considered cessation of transfusion requirements with normalization of hemoglobin (Hb) values; partial response was defined as a > 30% reduction in transfusional needs or an increase > 10 g/L in the Hb. The effect on platelet counts was also analyzed. RESULTS: One patient splenectomized three years earlier achieved a complete response and three a partial response, giving an overall response rate of 57 %. A significant increase in platelet counts was also observed in three responders. The responses were first seen between three and six months after the start of treatment, which was usually well tolerated. INTERPRETATION AND CONCLUSIONS: Danazol, given at an appropriate dosage for a sufficient time, is an effective treatment for a substantial proportion of IM patients with severe anemia without marked splenomegaly or who have been previously splenectomized.  (+info)

Is endometrial pre-treatment of value in improving the outcome of transcervical resection of the endometrium? (4/116)

The aim of this study was to determine whether or not the use of medical pre-treatment of the endometrium improves the outcome of transcervical resection of the endometrium with regards to long-term operative outcome, histological findings and patient satisfaction. A prospective randomized trial comparing three endometrial pre-treatment agents (danazol, medroxyprogesterone acetate or nafarelin) with no pre-treatment was conducted. The main outcome measures were: (i) thickness of the endometrium and myometrium resected; (ii) histological stage of the endometrium at the time of operation; (iii) the presence or absence of menses and (iv) patient satisfaction 1 year post-operatively. Of the three pre-treatments studied, danazol produced a lower median endometrial thickness than the control, showed the greatest ability to induce atrophy of the endometrial glands and stroma (not statistically significant) and produced the highest rate of amenorrhoea (not different to the control). Danazol and nafarelin produced significantly lower median endometrial thickness than no pre-treatment. There were, however, no significant differences in the rates of amenorrhoea in any of the pre-treatment groups compared with that in the control group. No improvement in clinical outcome or patient satisfaction is conferred by the use of medical pre-treatments if transcervical resection of the endometrium is performed in the proliferative phase of the menstrual cycle.  (+info)

Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. (5/116)

A prospective multicenter trial of 119 children 1 to 18 years of age with newly diagnosed aplastic anemia (AA) was conducted, comparing treatment using antithymocyte globulin (ATG), cyclosporine (CyA), and danazol (DAN) with or without rhG-CSF (400 microg/m(2), day on days 1-90). All children with very severe AA received rhG-CSF (VSAA group, n = 50). The other children were randomized to receive ATG, CyA, DAN, and rhG-CSF (G-CSF+ group, n = 35) or ATG, CyA, and DAN without rhG-CSF (G-CSF- group, n = 34). After 6 months, the hematologic response rate was 71%, 55%, and 77% in the VSAA group, G-CSF+ group, and G-CSF- group, respectively. There was no difference in the incidence of febrile episodes and documented infections between the G-CSF+ and G-CSF- groups. Bone marrow transplantation (BMT) was attempted in 22 patients in whom initial immunosuppressive therapy (IST; n = 18) failed or in whom a relapse occurred after an initial response (n = 4). Nineteen of the 22 patients are alive and well after a median follow-up of 18 months (range, 3 to 66 months) since BMT. The probability of survival at 4 years was 83% +/- 7% in the VSAA group, 91% +/- 5% in the G-CSF+ group, and 93% +/- 6% in the G-CSF- group. Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) developed in one patient in each of the three groups; the overall risk for MDS/AML was 3% +/- 2% at 4 years. Because the results of IST were encouraging, it is suggested that children with AA receive IST as first-line therapy if there is no human leukocyte antigen-matched sibling donor.  (+info)

The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot. (6/116)

BACKGROUND: Endometriosis is defined as an inflammatory condition of the female reproductive tract, a state often associated with infertility and miscarriage. Many exogenously administered factors (treatments) control the disease via as yet unknown pathways. Possible candidate molecules involved in these mechanisms could be the serum-soluble human leukocyte antigens (sHIA) that have been detected in a variety of human body fluids and that are associated with several diseases. AIMS: We here examine how danazol and leuprorelin acetate depot treatments exert their anti-inflammatory action. It is plausible that subtle alterations mediated by these treatments and in relation to sHLA may explain the pathophysiology of endometriosis and provide insights towards new therapeutic protocols. METHODS: Indirect enzyme-linked immunosorbent assay (ELISA), using specific monoclonal antibodies, determined serum-soluble class-I and class-II HLA levels. ELISA readings from treated women were compared with normal healthy subjects. RESULTS: Serum-soluble class-I and class-II HLA levels are statistically significantly lower (P < 0.001) in women with endometriosis than in the control groups. However, danazol but not leuprorelin acetate depot administration augments soluble HLA class I and class II (P < 0.01 and P < 0.001, respectively) to normal levels during the treatment period, an increase that may account for the anti-inflammatory effect and the remission observed. CONCLUSIONS: It is shown that one of the underlying causes of endometriosis may be the lack of both circulating class-I and class-II antigen levels. Danazol administration acts via an induced release of these antigens, whose presence correlates with the degree of the inflammatory alleviation obtained. We thus provide evidence that the inflammatory state of the disease appears to be associated with soluble HLA levels because, 3 months after ceasing therapy, the circulating antigens in the serum return to the same levels that correspond to the pathological condition.  (+info)

Danazol and limb-threatening arterial thrombosis: two case reports. (7/116)

Danazol is a synthetic androgenic steroid used clinically for the treatment of a wide variety of disorders. Although there is no extensive evidence that androgens are thrombogenic in humans, there are case reports of cerebral, coronary, and peripheral arterial thrombosis in young male athletes abusing anabolic-androgenic steroids. There are also two reported cases of arterial and venous thrombotic events attributed to danazol therapy. We report two additional cases of limb-threatening arterial thrombosis in patients undergoing danazol therapy, and suggest the possibility that danazol may be an independent risk factor for arterial thrombosis.  (+info)

Allogeneic stem cell transplantation for Evans syndrome. (8/116)

Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic steroids, vincristine, alkylating agents, or cyclosporine. In a patient with refractory disease, an allogeneic hematopoietic stem cell transplant (HSCT) resulted in complete clinical and serologic remission for more than 30 months. Allogeneic HSCT may be the only current curative therapy for Evans syndrome but may also be complicated by significant toxicities.  (+info)

Danazol is a synthetic, orally active androgenic steroid with antigonadotropic properties. It is used primarily in the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema. Danazol works by suppressing the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which in turn inhibits the growth of ovarian tissue and reduces the production of estrogen and progesterone. This leads to a decrease in the symptoms associated with endometriosis and fibrocystic breast disease. In the case of hereditary angioedema, danazol helps prevent attacks by increasing the levels of a protein called C1 esterase inhibitor, which is necessary for regulating the immune system and preventing inflammation.

The common side effects of danazol include weight gain, acne, oily skin, increased hair growth, changes in menstrual cycle, decreased breast size, deepening of the voice, and emotional lability. Rare but serious side effects may include liver damage, blood clots, and adrenal gland problems. Danazol is contraindicated in pregnancy due to its potential virilizing effects on the fetus. It should be used with caution in individuals with a history of liver disease, heart disease, or seizure disorders.

The medical definition of danazol can be summarized as follows:

Danazol (dan-a-zole)

A synthetic androgenic steroid with antigonadotropic properties, used primarily in the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema. Danazol suppresses the release of FSH and LH from the pituitary gland, inhibiting ovarian tissue growth and reducing estrogen and progesterone production. In hereditary angioedema, danazol increases C1 esterase inhibitor levels to prevent attacks. Common side effects include weight gain, acne, increased hair growth, menstrual changes, decreased breast size, deepened voice, and emotional lability. Rare but serious side effects may involve liver damage, blood clots, or adrenal gland problems. Danazol is contraindicated in pregnancy due to potential virilizing effects on the fetus and should be used with caution in individuals with a history of liver disease, heart disease, or seizure disorders.

Pregnadienes are a class of steroid hormones that contain a unsaturated bond between the C4 and C5 positions in their steroid nucleus. They are important precursors in the biosynthesis of various sex steroids, such as progesterone and testosterone, in the human body. Pregnadienes are derived from pregnanes, which have a saturated bond at this position. The term "pregnadiene" refers to the chemical structure of these hormones, specifically their double bond at the C4-C5 position. They play a crucial role in the regulation of various physiological processes related to reproduction and sexual development.

Ethisterone is a synthetic steroid hormone that has progestogenic and androgenic activity. Its chemical name is pregneninolone acetate, and it is used in some medical treatments, such as for certain types of breast cancer and for the treatment of menstrual disorders. It is not commonly used today due to the availability of other hormonal therapies with more favorable side effect profiles. As with any medication, it should only be used under the guidance of a healthcare professional.

Estrogen antagonists, also known as antiestrogens, are a class of drugs that block the effects of estrogen in the body. They work by binding to estrogen receptors and preventing the natural estrogen from attaching to them. This results in the inhibition of estrogen-mediated activities in various tissues, including breast and uterine tissue.

There are two main types of estrogen antagonists: selective estrogen receptor modulators (SERMs) and pure estrogen receptor downregulators (PERDS), also known as estrogen receptor downregulators (ERDs). SERMs, such as tamoxifen and raloxifene, can act as estrogen agonists or antagonists depending on the tissue type. For example, they may block the effects of estrogen in breast tissue while acting as an estrogen agonist in bone tissue, helping to prevent osteoporosis.

PERDS, such as fulvestrant, are pure estrogen receptor antagonists and do not have any estrogen-like activity. They are used primarily for the treatment of hormone receptor-positive breast cancer in postmenopausal women.

Overall, estrogen antagonists play an important role in the management of hormone receptor-positive breast cancer and other conditions where inhibiting estrogen activity is beneficial.

Endometriosis is a medical condition in which tissue similar to the lining of the uterus (endometrium) grows outside the uterine cavity, most commonly on the ovaries, fallopian tubes, and the pelvic peritoneum. This misplaced endometrial tissue continues to act as it would inside the uterus, thickening, breaking down, and bleeding with each menstrual cycle. However, because it is outside the uterus, this blood and tissue have no way to exit the body and can lead to inflammation, scarring, and the formation of adhesions (tissue bands that bind organs together).

The symptoms of endometriosis may include pelvic pain, heavy menstrual periods, painful intercourse, and infertility. The exact cause of endometriosis is not known, but several theories have been proposed, including retrograde menstruation (the backflow of menstrual blood through the fallopian tubes into the pelvic cavity), genetic factors, and immune system dysfunction.

Endometriosis can be diagnosed through a combination of methods, such as medical history, physical examination, imaging tests like ultrasound or MRI, and laparoscopic surgery with tissue biopsy. Treatment options for endometriosis include pain management, hormonal therapies, and surgical intervention to remove the misplaced endometrial tissue. In severe cases, a hysterectomy (removal of the uterus) may be recommended, but this is typically considered a last resort due to its impact on fertility and quality of life.

I am not aware of a medical definition for "Cortodoxone." It is possible that this term is not recognized in the field of medicine as it does not appear to be a commonly used medication, treatment, or diagnostic tool. If you have any more information about where you encountered this term or its potential meaning, I would be happy to try and provide further clarification.

Fibrocystic breast disease, also known as fibrocystic change or chronic cystic mastitis, is not actually a disease but a condition that affects many women at some point in their lives. It is characterized by the formation of benign (non-cancerous) lumps or cysts in the breasts, often accompanied by breast pain, tenderness, and swelling.

The condition is caused by hormonal fluctuations that affect the breast tissue, making it more prone to developing fibrous tissue and fluid-filled sacs called cysts. Fibrocystic breast changes are usually harmless and do not increase the risk of breast cancer. However, in some cases, they can make it harder to detect early signs of breast cancer through mammography or self-examination.

The symptoms of fibrocystic breast change may vary from woman to woman and can range from mild to severe. They tend to be more noticeable just before a woman's menstrual period and may improve after menopause. Treatment options for fibrocystic breast changes include pain relievers, hormonal medications, and lifestyle modifications such as reducing caffeine intake and wearing a well-supportive bra. In some cases, draining or removing the cysts may be necessary to alleviate symptoms.

Premenstrual Syndrome (PMS) is a complex of symptoms that occur in the latter part of the luteal phase (the second half) of the menstrual cycle, typically starting 5-11 days before the onset of menses, and remitting shortly after the onset of menstruation. The symptoms can be physical, psychological, or behavioral and vary from mild to severe. They include but are not limited to: bloating, breast tenderness, cramps, headaches, mood swings, irritability, depression, anxiety, fatigue, changes in appetite, and difficulty concentrating.

The exact cause of PMS is not known, but it appears to be related to hormonal changes during the menstrual cycle, particularly fluctuations in estrogen and progesterone levels. Some women may be more susceptible to these hormonal shifts due to genetic factors, neurotransmitter imbalances, or other health conditions.

Treatment for PMS often involves a combination of lifestyle changes (such as regular exercise, stress management, and dietary modifications), over-the-counter pain relievers, and, in some cases, hormonal medications or antidepressants. It's important to consult with a healthcare provider for an accurate diagnosis and treatment plan.

Menorrhagia is a medical term used to describe abnormally heavy or prolonged menstrual periods. It's often characterized by the loss of an excessive amount of menstrual blood (usually more than 80 ml) and can last longer than normal, typically over seven days. This condition can have significant impacts on a woman's quality of life, causing fatigue, distress, and restrictions in daily activities due to the need for frequent pad or tampon changes.

The causes of menorrhagia are varied and can include hormonal imbalances, uterine fibroids or polyps, endometrial hyperplasia, pelvic inflammatory disease, pregnancy complications, certain medications, and underlying medical conditions such as coagulopathies or thyroid disorders. In some cases, the cause may remain undetermined even after a thorough evaluation.

Treatment options for menorrhagia depend on the underlying cause and range from medication management with hormonal therapies, nonsteroidal anti-inflammatory drugs (NSAIDs), or tranexamic acid to procedural interventions like endometrial ablation, hysteroscopic resection of polyps or fibroids, or ultimately hysterectomy in severe cases. It is essential for individuals experiencing menorrhagia to consult with their healthcare provider to determine the best course of action based on their specific situation and medical history.

Idiopathic Thrombocytopenic Purpura (ITP) is a medical condition characterized by a low platelet count (thrombocytopenia) in the blood without an identifiable cause. Platelets are small blood cells that help your body form clots to stop bleeding. When you don't have enough platelets, you may bleed excessively or spontaneously, causing purpura, which refers to purple-colored spots on the skin that result from bleeding under the skin.

In ITP, the immune system mistakenly attacks and destroys platelets, leading to their decreased levels in the blood. This condition can occur at any age but is more common in children following a viral infection, and in adults after the age of 30-40 years. Symptoms may include easy or excessive bruising, prolonged bleeding from cuts, spontaneous bleeding from the gums or nose, blood blisters, and small red or purple spots on the skin (petechiae).

Depending on the severity of thrombocytopenia and the presence of bleeding symptoms, ITP treatment may include observation, corticosteroids, intravenous immunoglobulin (IVIG), or other medications that modify the immune system's response. In severe cases or when other treatments are ineffective, surgical removal of the spleen (splenectomy) might be considered.

Thrombocytopenic purpura (TTP) is a rare blood disorder characterized by the abnormal breakdown of platelets, leading to a low platelet count (thrombocytopenia). Platelets are small blood cells that help your body form clots to stop bleeding. A low platelet count can cause purple spots on the skin (purpura) and easy or excessive bruising or bleeding.

TTP is caused by the formation of blood clots in small blood vessels throughout the body, which can lead to serious complications such as damage to the heart, brain, and kidneys if left untreated. The condition can be acute (sudden onset) or chronic (long-term).

TTP is often caused by an autoimmune response where the body's immune system produces antibodies that attack and destroy a protein called ADAMTS13, which is necessary for breaking down large von Willebrand factor proteins in the blood. Without enough ADAMTS13, these proteins can form clots and deplete platelets, leading to thrombocytopenia and purpura.

Treatment typically involves plasma exchange therapy to replace the missing or nonfunctional ADAMTS13 protein and suppress the immune system's production of antibodies. Corticosteroids, immunosuppressive drugs, and rituximab may also be used in treatment.

The volume of distribution of danazol is 3.4 L. Danazol is known to be plasma protein bound to albumin, SHBG, and CBG. Danazol ... Intake of danazol with food (>30 grams of fat) has been found to increase the bioavailability and peak levels of danazol by 3- ... Danazol appears to be useful in the treatment of systemic lupus erythematosus. Danazol comes in the form of 50, 100, and 200 mg ... The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening. Danazol ...
"Danazol". Medscape. 2002. Retrieved 2006-11-08. "Contraception: past, present and future". UK Family Planning Association. ... Danazol was tested in the early 1980s in the hopes that it would have fewer side effects than Yuzpe, but was found to be ...
Redirects to Danazol. cyclomenol (INN) cyclomethycaine (INN) Cyclomydril Cyclopar cyclopentamine (INN) cyclopenthiazide (INN) ...
American journal of ..., 1987 Richard P. Dickey, A. Albert Yuzpe (1985). Managing Cyclomen (Danazol) Patients. Jacques-E. Rioux ...
Danazol was described as a luteolytic agent. Cloprostenol is another example of such an agent. "Luteolysis - Google Search". ... Danazol as a luteolytic agent. Fertil Steril. 1978;29(1):23-5. PMID 620838 Bagnell, C. 2005. "Animal Reproduction". Rutgers ...
In 1991 the FDA required a black box warning that use of danazol in pregnancy is contraindicated because exposure to danazol in ... The black box warning recommends a sensitive hCGβ-subunit pregnancy test immediately prior to starting danazol therapy and use ... Brunskill PJ (February 1992). "The effects of fetal exposure to danazol". Br J Obstet Gynaecol. 99 (3): 212-5. doi:10.1111/j. ... No genital anomalies were reported where danazol therapy was discontinued before the 8th week of pregnancy. The warnings ...
Danazol Treatment for Telomere Diseases. N Engl J Med. 2016 May 19;374(20):1922-31. Townsley DM, Scheinberg P, Winkler T, ... 2021 May 27;384(21):2039-2052[6] Danazol Treatment for Telomere Diseases. N Engl J Med. 2016 May 19;374(20):1922-31.[7] ...
Examples: drostanolone, oxymetholone, stanozolol, danazol. A hydroxyl group (instead of a ketone) at the C3 position and/or a ...
... is a major active metabolite of danazol (2,3-isoxazolethisterone), and is thought to contribute importantly to its ... Barbieri RL, Ryan KJ (October 1981). "Danazol: endocrine pharmacology and therapeutic applications". American Journal of ... and danazol (the 2,3-d-isoxazole ring-fused derivative of ethisterone), as well as vinyltestosterone, allyltestosterone, ...
... but were not more effective than danazol or intrauterine progestogen, and had more side effects than danazol. A 2018 Swedish ... Danazol was first described for endometriosis in 1971 and became the main therapy in the 1970s and 1980s. In the 1980s GnRH ... "DANOCRINE : Brand of DANAZOL CAPSULES, USP" (PDF). Accessdata.fda.gov. Retrieved 3 March 2022. D'Alterio MN, D'Ancona G, Raslan ... Danazol and gestrinone are suppressive steroids with some androgenic activity. Both agents inhibit the growth of endometriosis ...
Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol". Acta ... Inhibitors of STS include irosustat, estrone sulfamate (EMATE), estradiol sulfamate (E2MATE), and danazol. The most potent ...
Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol". Acta ... Steroid sulfatase (STS) inhibitors such as estradiol sulfamate, estrone sulfamate, irosustat, and danazol inhibit the ...
He also showed that the drug Danazol was useful in the management of endometriosis and fibrocystic breast disease. Greenblatt's ... Greenblatt, R., & Ben-Nunn, I. (1980). Danazol in the Treatment of Mammary Dysplasia. Drugs(19), 349-355. Greenblatt, R., ... Greenblatt , R., & Tzingounis, V. (1979). Danazol Treatment of Endometriosis: Long-term Follow Up. Fertility and Sterility, 32 ... Mahesh, V., & Dmowski, P., Scholoer, H. (1969). Danazol - A Synthetic Steroid Derivative with Interesting Physiologic ...
La Shell, M. S.; England, R. W. (2006). "Severe refractory cholinergic urticaria treated with danazol". Journal of Drugs in ... Treatment(s) with mixed success: omalizumab (anti-IgE therapy), danazol (synthetic androgen), propranolol (beta blocker), ...
... or the endometriosis drug danazol. Reduced maximum doses of simvastatin apply for patients taking certain other drugs, ...
189-. ISBN 978-94-011-4439-1. Barbieri RL (February 1990). "Comparison of the pharmacology of nafarelin and danazol". American ...
Occasionally danazol or tamoxifen may be used for pain. It is estimated that up to 60% of women are affected. Most commonly ...
Tranexamic acid, danazol, progesterone IUDs, and NSAIDs are also helpful. Surgery can be an effective for those whose symptoms ...
1993). "[Effective danazol therapy for a patient with Evans syndrome]". Rinsho Ketsueki (in Japanese). 34 (2): 143-6. PMID ... vincristine and danazol) are subsequently used, or combinations of these. The off-label use of rituximab (trade name Rituxan) ...
"Successful treatment of D-penicillamine-induced breast gigantism with danazol". British Medical Journal. 282 (6261): 362-363. ...
In those with severe pain tamoxifen or danazol may be used. About 70% of women have breast pain at some point in time. Breast ... In those with severe pain tamoxifen or danazol may be used. Bromocriptine may be used as well. Spironolactone, low dose oral ...
Danazol, gestrinone, and paroxypropione have all been classified specifically as antigonadotropins. Prolactin has ... as well as steroid synthesis inhibitors such as danazol and gestrinone. Since progestins have relatively little effect on ...
Examples of AAS containing the isoxazole ring include danazol and androisoxazole. A number of pesticides are isoxazoles. ...
Wong, E; Eftekhari, N; Greaves, M. W.; Ward, A. M. (1987). "Beneficial effects of danazol on symptoms and laboratory changes in ...
Unlike danazol, gestrinone does not appear to bind to SHBG or corticosteroid-binding globulin (CBG). Gestrinone is bound to ... It is described as similar in action and effect to danazol, which is also used in the treatment of endometriosis, but is ... Gestrinone appears to show similar effectiveness to danazol in the treatment of endometriosis but with fewer side effects, in ... Similarly to danazol, gestrinone acts as a weak antigonadotropin via activation of the PR and AR in the pituitary gland and ...
Medications may be used to treat ORS and include GnRH agonists, danazol, or progesterone. The incidence of ovarian remnant ...
Androgens, anabolic steroids such as danazol, glucocorticoids, and slow release nicotinic acid all decrease TBG concentrations ...
... danazol, cyclosphosphamide, azathioprine, or ciclosporin. High-dose intravenous immune globulin may be effective in controlling ...
Jennifer, Higham (1993). The clinical evaluation of unexplained menorrhagia and its treatment with danazol and norethisterone ( ...
Future attacks of HAE can be prevented by the use of androgens such as danazol, oxandrolone or methyltestosterone. These agents ...
The volume of distribution of danazol is 3.4 L. Danazol is known to be plasma protein bound to albumin, SHBG, and CBG. Danazol ... Intake of danazol with food (>30 grams of fat) has been found to increase the bioavailability and peak levels of danazol by 3- ... Danazol appears to be useful in the treatment of systemic lupus erythematosus. Danazol comes in the form of 50, 100, and 200 mg ... The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening. Danazol ...
Danazol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to ... Danazol may cause liver damage with abdominal bleeding in people who take danazol for a long time. Tell your doctor if you have ... tell your doctor and pharmacist if you are allergic to danazol, any other medications, or any of the ingredients in danazol ...
Find information on Danazol (Danocrine) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "Danazol." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. The Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/51193/all/danazol. Vallerand AHA, Sanoski CAC, Quiring CC. Danazol. Daviss Drug Guide. ... TY - ELEC T1 - danazol ID - 51193 A1 - Sanoski,Cynthia A, AU - Vallerand,April Hazard, AU - Quiring,Courtney, BT - Daviss Drug ...
Anargil information about active ingredients, pharmaceutical forms and doses by Medochemie, Anargil indications, usages and related health products lists
He asked my wife to take Danazol. Is my wife on the right mode of treatment? Will my wife conceive with the help of Danazol? ... He asked my wife to take Danazol. Is my wife on the right mode of treatment? Will my wife conceive with the help of Danazol? ... Does Danazol help in conceiving and treating endometriosis?. Answered by: Prof Mini Sood , Associate Professor, Department of ... Danazol is effective in treating the endometriosis, but takes a long time and prevents pregnancy from occurring. ...
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Evans syndrome is the coexistence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) with immune-mediated thrombocytopenia. In the initial description by Evans et al in 1951, the anemia and thrombocytopenia varied with respect to time of onset, course, and duration.
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  • Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions. (wikipedia.org)
  • Do not take danocrine (danazol) 200mg capsule if you are allergic to it or any of the components present in it. (daynightdrugs.com)
  • Danazol decreases effects of insulin and oral hypoglycemic drugs by affecting metabolism of carbohydrates, increasing blood sugar levels Danazol inhibits metabolism of carbamazepine and increase its blood levels increases blood concentrations of cyclosporine and tacrolimus hereby increasing risk of nephrotoxicity. (treatstoreweb.com)
  • Danazol is also used to prevent attacks in people with hereditary angioedema (inherited condition that causes episodes of swelling in the hands, feet, face, airway, or intestines). (medlineplus.gov)
  • In terms of hereditary angioedema, danazol corrects the underlying biochemical deficiency by increasing serum concentrations of the deficient C1 esterase inhibitor, resulting in increased serum concentrations of the C4 component of the complement system. (drugbank.com)
  • Danazol is a drug most widely used for the prophylaxis of hereditary angioedema resulting from the deficiency of the C1-inhibitor. (chaen-rcah.ca)
  • Potential hepatotoxic or liver tumor-inducing side effects of long-term danazol prophylaxis have been investigated during the follow-up of hereditary angioedema patients. (chaen-rcah.ca)
  • From a population of 126 hereditary angioedema patients, 46 subjects taking danazol and another 46 not taking danazol fulfilled the inclusion criteria. (chaen-rcah.ca)
  • Our results clearly suggest that, administered at the lowest effective dose, danazol does not induce liver injury in hereditary angioedema patients. (chaen-rcah.ca)
  • If you experience any of the following symptoms stop taking danazol and call your doctor immediately: headache, nausea, vomiting, or problems with your vision. (medlineplus.gov)
  • Do not stop taking danazol without talking to your doctor. (medlineplus.gov)
  • If your regular monthly period does not begin within 60 to 90 days after you stop taking danazol, check with your doctor right away. (pharm-europe.com)
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  • Due to their improved side-effect profiles, particularly their lack of masculinizing side effects, danazol has largely been replaced by gonadotropin-releasing hormone analogues (GnRH analogues) in the treatment of endometriosis. (wikipedia.org)
  • Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen. (wikipedia.org)
  • Danazol is described as a possessing high affinity for the androgen receptor (AR), moderate affinity for the progesterone receptor (PR) and glucocorticoid receptor (GR), and poor affinity for the estrogen receptor (ER). (wikipedia.org)
  • As an androgen, danazol is described as weak, being about 200-fold less potent than testosterone in bioassays. (wikipedia.org)
  • Drug Class and Mechanism Danazol is a synthetic androgen (male sex hormone. (generic-meds-store.com)
  • This medication cannot be used in patients with hypersensitivity to Danazol or its components, in pregnant and breastfeeding women, porphyria (activity of liver transaminases increases), liver or kidney failure, chronic heart failure, thromboembolism, androgen producing tumor, vaginal bleeding of unknown origin. (treatstoreweb.com)
  • Danazol is used primarily in the treatment of endometriosis. (wikipedia.org)
  • The use of danazol for endometriosis has been linked to an increased risk of ovarian cancer. (wikipedia.org)
  • Danazol is used to treat endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes infertility, pain before and during menstrual periods, pain during and after sexual activity, and heavy or irregular bleeding). (medlineplus.gov)
  • Does Danazol help in conceiving and treating endometriosis? (ndtv.com)
  • Home » Frequently asked Questions on Health » Does Danazol help in conceiving and treating endometriosis? (ndtv.com)
  • If your wife is having endometriosis and infertility, then Danazol is not going to help her conceive soon. (ndtv.com)
  • Danazol is effective in treating the endometriosis, but takes a long time and prevents pregnancy from occurring. (ndtv.com)
  • Danazol is indicated for the treatment of endometriosis amenable to hormonal management. (pharm-europe.com)
  • Danazol is a synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. (drugbank.com)
  • Danazol has been used in the treatment of endometriosis and some benign breast disorders. (drugbank.com)
  • Another mechanism of action by which danazol may use to facilitate regression of endometriosis is by decreasing IgG, IgM, and IgA concentrations, as well as phospholipid and IgG isotope autoantibodies. (drugbank.com)
  • In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both normal and ectopic endometrial tissues to become inactive and atrophic. (drugbank.com)
  • Danazol (Danazol) is a synthetic hormone, used to treat pain and infertility caused by endometriosis. (generic-meds-store.com)
  • Danazol is used in heavy menstrual bleeding, endometriosis and benign fibrocystic breast disease. (epharmaleads.com)
  • Danazol is a synthetic steroid hormone used in treatment of endometriosis, fibrocystic breast disease, benign breast tumors, abnormally long periods, premenstrual syndrome, gynecomastia. (treatstoreweb.com)
  • Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study. (rush.edu)
  • Dmowski WP, Radwanska E, Binor Z, Tummon I, Pepping P. Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study. (rush.edu)
  • As a gonadotropin inhibitor, danazol suppresses the pituitary-ovarian axis possibly by inhibiting the output of pituitary gonadotropins. (drugbank.com)
  • Danazol also depresses the preovulatory surge in output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. (drugbank.com)
  • In fibrocystic breast disease, the exact mechanism of action of danazol is unknown, but may be related to suppressed estrogenic stimulation as a result of decreased ovarian production of estrogen. (drugbank.com)
  • Danazol comes in the form of 50, 100, and 200 mg oral capsules. (wikipedia.org)
  • The following information includes only the average doses of danazol. (pharm-europe.com)
  • This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. (nih.gov)
  • Androgenic side effects are of concern, as some women taking danazol may experience unwanted hair growth (hirsutism), acne, irreversible deepening of the voice, or adverse blood lipid profiles. (wikipedia.org)
  • Danazol is in a class of medications called androgenic hormones. (medlineplus.gov)
  • Although the affinity and efficacy of danazol itself at the PR are relatively low, ethisterone, one of the major metabolites of danazol, is described as a weak progestogen (and has been employed clinically as a progestogen), and this presumably serves to increase the in vivo progestogenic activity of danazol. (wikipedia.org)
  • Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. (drugbank.com)
  • Danazol is a synthetic steroid produced from ethisterone. (treatstoreweb.com)
  • Danazol is also used to treat fibrocystic breast disease (swollen, tender breasts with noncancerous lumps) when other treatments are not successful. (medlineplus.gov)
  • I was diagnosed with Fibrocystic Breast Disease and was prescribed Danazol for the same. (completeonlinepharmacy.com)
  • Since danazol is metabolized by the liver, it cannot be used by patients with liver disease, and in patients receiving long-term therapy, liver function must be monitored on a periodic basis. (wikipedia.org)
  • Danazol, like most other anabolic steroids, has been linked with an increased risk of liver tumors. (wikipedia.org)
  • Danazol may cause liver damage with abdominal bleeding in people who take danazol for a long time. (medlineplus.gov)
  • Danazol may cause heart or circulation problems (blood clots), liver problems or increase pressure on the brain. (canadian-cheaprx.com)
  • Characteristic parameters of liver function (including bilirubin, GOT, GPT, gammaGT, total protein, ALP, LDH), as well as findings of viral serology screens and abdominal ultrasonography-determined during years 0 and 5 of follow-up of patient groups taking/not taking danazol-have been reviewed and analyzed comparatively. (chaen-rcah.ca)
  • Danazol possesses a complex pharmacology, with multiple mechanisms of action. (wikipedia.org)
  • Danazol must not be taken by women who are pregnant or who could become pregnant. (medlineplus.gov)
  • If you become pregnant while taking danazol, call your doctor immediately. (medlineplus.gov)
  • Using danazol while you are pregnant can harm your unborn baby. (pharm-europe.com)
  • If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using danazol to make sure you are not pregnant. (pharm-europe.com)
  • Danazol may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control during your treatment. (medlineplus.gov)
  • Use reliable and effective forms of contraception while you are on Danazol such as a condom or diaphragm with spermicide gel or inserts as hormonal forms of contraception may turn out non effective. (treatstoreweb.com)
  • Effective, non-hormonal birth control measures (such as diaphragms and condoms) should be used while using danazol. (canadian-cheaprx.com)
  • Women taking danazol should practice effective contraception to prevent pregnancy if sexually active. (wikipedia.org)
  • The activity of danazol at the ER is considered to be minimal, although at very high concentrations the drug can act significantly as an ER agonist. (wikipedia.org)
  • The Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/51193/all/danazol. (unboundmedicine.com)
  • 4. Initiation of treatment with an erythropoiesis-stimulating agent (eg, erythropoietin), a thrombopoietin receptor agonist (eg, eltrombopag), or danazol within 28 days prior to the screening visit. (who.int)
  • Although not currently a standard treatment for menorrhagia, danazol demonstrated significant relief in young women with menorrhagia in a study, and, because of a lack of a significant adverse effects, it was proposed as an alternative treatment. (wikipedia.org)
  • Danazol appears to be useful in the treatment of systemic lupus erythematosus. (wikipedia.org)
  • Your doctor may order certain lab tests before and during your treatment to check your body's response to danazol. (medlineplus.gov)
  • In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor. (pharm-europe.com)
  • Danazol is considered a second line treatment. (generic-meds-store.com)
  • The use of danazol is limited by masculinizing side effects such as acne, excessive hair growth, and voice deepening. (wikipedia.org)
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  • The dose of danazol will be different for different patients. (pharm-europe.com)
  • Check with your doctor right away if you are a female and have a larger clitoris (sexual organ), deepening of your voice, or unusual hair growth after taking danazol. (pharm-europe.com)
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  • Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder. (canadianokpharmacy.com)
  • Danazol is contraindicated during pregnancy because it has the potential to virilize female fetuses. (wikipedia.org)
  • Talk to your doctor about the risks of taking danazol. (medlineplus.gov)
  • It is very important that you use danazol only as directed by your doctor. (pharm-europe.com)
  • It is very important that your doctor check your progress at regular visits to make sure that danazol does not cause unwanted effects. (pharm-europe.com)
  • Tell any doctor who treats you that you are using Danazol. (canadianokpharmacy.com)
  • Danazol must be taken as prescribed by the doctor. (canadian-cheaprx.com)
  • You must start taking danazol while you are having your monthly period. (pharm-europe.com)
  • Danazol is used to treat a number of different medical problems. (pharm-europe.com)