AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Cytomegalovirus InfectionsCytomegalovirusMuromegalovirusGanciclovirCytomegalovirus RetinitisCytomegalovirus VaccinesHerpesviridae InfectionsAntiviral AgentsAntibodies, ViralFoscarnetDNA, ViralImmediate-Early ProteinsImmunocompetenceAntigens, ViralPregnancy Complications, InfectiousVirus ReplicationViral ProteinsKidney TransplantationVirus ActivationRoseolovirusViral Matrix ProteinsFibroblastsImmunocompromised HostGastritis, HypertrophicImmunoglobulin MPolymerase Chain ReactionOpportunistic InfectionsInfant, NewbornTransplantation, HomologousGenes, Immediate-EarlySalivary GlandsViremiaFetal DiseasesUrineInfectious Disease Transmission, VerticalComplement Fixation TestsCells, CulturedOrgan TransplantationGene Expression Regulation, ViralImmunoglobulin GPneumonia, ViralAIDS-Related Opportunistic InfectionsPregnancyRibonucleosidesMice, Inbred BALB CHerpesvirus 6, HumanCell LineKiller Cells, NaturalViral Plaque AssayBone Marrow TransplantationAcyclovirViral LoadViral Envelope ProteinsImmunosuppressionTime FactorsInfant, Newborn, DiseasesGraft RejectionCytopathogenic Effect, ViralSpleenGenes, ViralCytosineOrganophosphonatesPostoperative ComplicationsInclusion Bodies, ViralNK Cell Lectin-Like Receptor Subfamily AImmunity, CellularMolecular Sequence DataPhosphoproteinsLiver TransplantationVirus LatencyTransplantationImmunosuppressive AgentsCD8-Positive T-LymphocytesNeonatal ScreeningLung TransplantationVirologyHypoproteinemiaHearing Loss, SensorineuralBase SequenceSerologic TestsLymphotoxin alpha1, beta2 HeterotrimerHeart TransplantationOrganophosphorus CompoundsAcquired Immunodeficiency SyndromeRoseolovirus InfectionsTissue DonorsChild CareHearing Loss, CentralEnzyme-Linked Immunosorbent AssayMice, Inbred C57BLLymphocyte ActivationProspective StudiesAcute DiseaseFluorescent Antibody TechniqueHematopoietic Stem Cell TransplantationTransplantsVirus CultivationRetrospective StudiesHerpesviridaeT-LymphocytesPlacenta DiseasesChorionic VilliSplenomegalyHost-Pathogen InteractionsSensitivity and SpecificityAmniotic FluidTransplantation ImmunologyGraft SurvivalRisk FactorsHepatitisHistocompatibility Antigens Class ILungInterferon-gammaPsychomotor DisordersLeukocytesAntilymphocyte SerumInfectious MononucleosisMicrocephalyTreatment OutcomeBetaherpesvirinaeHerpes SimplexAmino Acid SequenceSpecific Pathogen-Free OrganismsNK Cell Lectin-Like Receptor Subfamily CBALB 3T3 CellsImmunoglobulins, IntravenousRecurrenceSeroepidemiologic StudiesGastrointestinal DiseasesIncidenceGraft vs Host DiseaseLiverRNA, ViralCD4-Positive T-LymphocytesMilk, HumanAlabamaPancreas TransplantationPolyradiculoneuropathyRetinitisMembrane GlycoproteinsNIH 3T3 Cells
Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Muromegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. Murid herpesvirus is the type species.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Cytomegalovirus Retinitis: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.Cytomegalovirus Vaccines: Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.Herpesviridae Infections: Virus diseases caused by the HERPESVIRIDAE.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Immunocompetence: The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Pregnancy Complications, Infectious: The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Viral Proteins: Proteins found in any species of virus.Kidney Transplantation: The transference of a kidney from one human or animal to another.Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.Roseolovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, whose viruses have been isolated from lymphocytes. HERPESVIRUS 6, HUMAN is the type species.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Gastritis, Hypertrophic: GASTRITIS with HYPERTROPHY of the GASTRIC MUCOSA. It is characterized by giant gastric folds, diminished acid secretion, excessive MUCUS secretion, and HYPOPROTEINEMIA. Symptoms include VOMITING; DIARRHEA; and WEIGHT LOSS.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Infant, Newborn: An infant during the first month after birth.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Genes, Immediate-Early: Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Viremia: The presence of viruses in the blood.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Infectious Disease Transmission, Vertical: The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.Complement Fixation Tests: Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Pneumonia, Viral: Inflammation of the lung parenchyma that is caused by a viral infection.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Ribonucleosides: Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)Mice, Inbred BALB CHerpesvirus 6, Human: The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Killer Cells, Natural: Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.Viral Plaque Assay: Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Spleen: An encapsulated lymphatic organ through which venous blood filters.Genes, Viral: The functional hereditary units of VIRUSES.Cytosine: A pyrimidine base that is a fundamental unit of nucleic acids.Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Inclusion Bodies, Viral: An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.NK Cell Lectin-Like Receptor Subfamily A: An inhibitory subclass of NK cell lectin-like receptors that interacts with CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS and prevents the activation of NK CELLS.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.PhosphoproteinsLiver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Virus Latency: The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Neonatal Screening: The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Virology: The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Serologic Tests: Diagnostic procedures involving immunoglobulin reactions.Lymphotoxin alpha1, beta2 Heterotrimer: A heterotrimer complex consisting of one molecule of LYMPHOTOXIN-ALPHA and two molecules of the LYMPHOTOXIN-BETA. It is anchored to the cell surface via the transmembrane domains of the lymphotoxin-beta component and has specificity for the LYMPHOTOXIN BETA RECEPTOR. The lymphotoxin alpha1, beta2 heterotrimer plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER CELLS.Heart Transplantation: The transference of a heart from one human or animal to another.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.Roseolovirus Infections: Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Child Care: Care of CHILDREN in the home or in an institution.Hearing Loss, Central: Hearing loss due to disease of the AUDITORY PATHWAYS (in the CENTRAL NERVOUS SYSTEM) which originate in the COCHLEAR NUCLEI of the PONS and then ascend bilaterally to the MIDBRAIN, the THALAMUS, and then the AUDITORY CORTEX in the TEMPORAL LOBE. Bilateral lesions of the auditory pathways are usually required to cause central hearing loss. Cortical deafness refers to loss of hearing due to bilateral auditory cortex lesions. Unilateral BRAIN STEM lesions involving the cochlear nuclei may result in unilateral hearing loss.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Mice, Inbred C57BLLymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Acute Disease: Disease having a short and relatively severe course.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Herpesviridae: A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Placenta Diseases: Pathological processes or abnormal functions of the PLACENTA.Chorionic Villi: The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).Splenomegaly: Enlargement of the spleen.Host-Pathogen Interactions: The interactions between a host and a pathogen, usually resulting in disease.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Amniotic Fluid: A clear, yellowish liquid that envelopes the FETUS inside the sac of AMNION. In the first trimester, it is likely a transudate of maternal or fetal plasma. In the second trimester, amniotic fluid derives primarily from fetal lung and kidney. Cells or substances in this fluid can be removed for prenatal diagnostic tests (AMNIOCENTESIS).Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Hepatitis: INFLAMMATION of the LIVER.Histocompatibility Antigens Class I: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Psychomotor Disorders: Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Antilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Infectious Mononucleosis: A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.Microcephaly: A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Betaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.Herpes Simplex: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Specific Pathogen-Free Organisms: Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.NK Cell Lectin-Like Receptor Subfamily C: A subclass of NK cell lectin-like receptors that associates with members of NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY D to form heterodimeric receptors for HLA-E antigen.BALB 3T3 Cells: Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Recurrence: The return of a sign, symptom, or disease after a remission.Seroepidemiologic Studies: EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Milk, HumanAlabamaPancreas Transplantation: The transference of a pancreas from one human or animal to another.Polyradiculoneuropathy: Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.Retinitis: Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.NIH 3T3 Cells: A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (1/3452)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation. (2/3452)

At our institution, the cytomegalovirus (CMV) prophylaxis protocol for allogeneic bone marrow transplant (BMT) recipients who are CMV-seropositive or receive marrow from a CMV-seropositive donor consists of a surveillance bronchoscopy approximately 35 days posttransplant. Patients with a positive surveillance bronchoscopy for CMV receive pre-emptive ganciclovir. In order to determine the utility of other screening methods for CMV, we prospectively performed weekly CMV antigenemia, and blood, urine and throat cultures from time of engraftment to day 120 post-BMT in 126 consecutive patients. Pre-emptive ganciclovir was given to 11/81 patients (13.6%) because of a positive surveillance bronchoscopy for CMV. Results of CMV blood, urine and throat cultures and the antigenemia assay done prior to or at the time of the surveillance bronchoscopy were analyzed for their ability to predict the bronchoscopy result. The antigenemia test had the highest positive and negative predictive values (72% and 96%, respectively). The ability of these tests to predict CMV disease was evaluated in the 70 patients with a negative surveillance bronchoscopy who did not receive pre-emptive ganciclovir. Of 19 cases of active CMV disease, CMV antigenemia was positive in 15 patients (79%) a mean of 34 days preceding symptoms. Blood cultures were positive in 14/19 patients (74%) a mean of 31 days before onset of disease. CMV antigenemia is useful for predicting the surveillance bronchoscopy result, and also predicts the development of CMV disease in the majority of patients missed by the surveillance bronchoscopy.  (+info)

Cytomegalovirus associated neonatal pneumonia and Wilson-Mikity syndrome: a causal relationship? (3/3452)

Lung injury caused by intrauterine inflammation has recently been strongly implicated in the pathogenesis of Wilson-Mikity syndrome (WMS). This article supports this theory by suggesting a causative role of intrauterine cytomegalovirus (CMV) infection for the development of WMS. A male premature infant, born at 33 weeks of gestational age, developed chronic lung disease compatible with WMS and diagnostic evaluation was positive for CMV infection. High-resolution computed tomography scan and lung histology revealed typical features of WMS in association with signs of interstitial pneumonia. CMV was found in urine, breastmilk, bronchoalveolar lavage material and lung tissue from open lung biopsy. Follow-up after treatment with ganciclovir and steroids showed resolving lung disease at the age of 6, 10 and 16 months, with lung function signs of mild obstruction. Assuming that a chance coexistence of cytomegalovirus pneumonia and Wilson-Mikity syndrome is rather unlikely, it is possible that intrauterine cytomegalovirus infection caused a pattern of lung injury consistent with Wilson-Mikity syndrome. Further cases of Wilson-Mikity syndrome should be investigated as to a possible role of congenital infection.  (+info)

Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients. (4/3452)

AIM: To identify cytomegalovirus (CMV) infection in liver transplant recipients by polymerase chain reaction (PCR) techniques and to separate the cases in which CMV related disease will occur, for whom treatment is indicated, from those in whom infection will remain innocuous. METHODS: The combination of qualitative and semiquantitative PCR of serum and urine was assessed to determine whether these assays can identify those at risk of CMV related disease and compared their performance with conventional approaches to diagnosis. RESULTS: Qualitative PCR of serum had superior specificity, sensitivity, and positive and negative predictive values compared with urine DEAFF (detection of early antigen fluorescent foci) and PCR of urine. All episodes of CMV related disease were associated with the presence of CMV DNA by PCR in serum or urine; CMV was detected before clinical onset in 70% and 60% of cases, respectively. The period over which CMV DNA could be detected was not correlated with CMV related disease. Both peak viral load and cumulative viral load estimated using a semiquantitative PCR method on serum samples positive by the qualitative method could be used to distinguish asymptomatic infection from CMV related disease with 100% specificity and sensitivity. In contrast semiquantitative PCR of urine was of little value. CONCLUSIONS: An approach based on PCR testing with a combination of qualitative and subsequently semiquantitative serum samples would improve the diagnosis of CMV infection and aid identification of those patients at risk of CMV related disease, allowing treatment to be targeted specifically.  (+info)

Effects of human cytomegalovirus major immediate-early proteins in controlling the cell cycle and inhibiting apoptosis: studies with ts13 cells. (5/3452)

The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) encodes several MIE proteins (MIEPs) produced as a result of alternative splicing and polyadenylation of the primary transcript. Previously we demonstrated that the HCMV MIEPs expressed from the entire MIE gene could rescue the temperature-sensitive (ts) transcriptional defect in the ts13 cell line. This defect is caused by a ts mutation in TAFII250, the 250-kDa TATA binding protein-associated factor (TAF). These and other data suggested that the MIEPs perform a TAF-like function in complex with the basal transcription factor TFIID. In addition to the transcriptional defect, the ts mutation in ts13 cells results in a defect in cell cycle progression which ultimately leads to apoptosis. Since all of these defects can be rescued by wild-type TAFII250, we asked whether the MIEPs could rescue the cell cycle defect and/or affect the progression to apoptosis. We have found that the MIEPs, expressed from the entire MIE gene, do not rescue the cell cycle block in ts13 cells grown at the nonpermissive temperature. However, despite the maintenance of the cell cycle block, the ts13 cells which express the MIEPs are resistant to apoptosis. MIEP mutants, which have previously been shown to be defective in rescuing the ts transcriptional defect, maintained the ability to inhibit apoptosis. Hence, the MIEP functions which affect transcription appear to be separable from the functions which inhibit apoptosis. We discuss these data in the light of the HCMV life cycle and the possibility that the MIEPs promote cellular transformation by a "hit-and-run" mechanism.  (+info)

Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. (6/3452)

Human cytomegalovirus (HCMV) infection was monitored retrospectively by qualitative determination of pp67 mRNA (a late viral transcript) by nucleic acid sequence-based amplification (NASBA) in a series of 50 transplant recipients, including 26 solid-organ (11 heart and 15 lung) transplant recipients (SOTRs) and 24 bone marrow transplant recipients (BMTRs). NASBA results were compared with those obtained by prospective quantitation of HCMV viremia and antigenemia and retrospective quantitation of DNA in leukocytes (leukoDNAemia). On the whole, 29 patients were NASBA positive, whereas 10 were NASBA negative, and the blood of 11 patients remained HCMV negative. NASBA detected HCMV infection before quantitation of viremia did but after quantitation of leukoDNAemia and antigenemia did. In NASBA-positive blood samples, median levels of viremia, antigenemia, and leukoDNAemia were significantly higher than the relevant levels detected in NASBA-negative HCMV-positive blood samples. By using the quantitation of leukoDNAemia as the "gold standard," the analytical sensitivity (47.3%), as well as the negative predictive value (68. 3%), of NASBA for the diagnosis of HCMV infection intermediate between that of antigenemia quantitation (analytical sensitivity, 72. 3%) and that of viremia quantitation (analytical sensitivity, 28.7%), while the specificity and the positive predictive value were high (90 to 100%). However, with respect to the clinically relevant antigenemia cutoff of >/=100 used in this study for the initiation of preemptive therapy in SOTRs with reactivated HCMV infection, the clinical sensitivity of NASBA reached 100%, with a specificity of 68. 9%. Upon the initiation of antigenemia quantitation-guided treatment, the actual median antigenemia level was 158 (range, 124 to 580) in SOTRs who had reactivated infection and who presented with NASBA positivity 3.5 +/- 2.6 days in advance and 13.5 (range, 1 to 270) in the group that included BMTRs and SOTRs who had primary infection (in whom treatment was initiated upon the first confirmation of detection of HCMV in blood) and who presented with NASBA positivity 2.0 +/- 5.1 days later. Following antiviral treatment, the durations of the presence of antigenemia and pp67 mRNA in blood were found to be similar. In conclusion, monitoring of the expression of HCMV pp67 mRNA appears to be a promising, well-standardized tool for determination of the need for the initiation and termination of preemptive therapy. Its overall clinical impact should be analyzed in future prospective studies.  (+info)

Multicenter comparison of the digene hybrid capture CMV DNA assay (version 2.0), the pp65 antigenemia assay, and cell culture for detection of cytomegalovirus viremia. (7/3452)

We compared the Digene Hybrid Capture CMV DNA Assay version 2.0, the pp65 antigenemia assay, traditional tube culture, and shell vial culture for the detection of cytomegalovirus (CMV) viremia in several patient populations at three centers. Of 561 blood specimens collected from 402 patients, complete clinical and laboratory data were available for 489. Using consensus definitions for true positives and true negatives, the sensitivities of the Hybrid Capture assay, antigenemia, shell vial, and tube culture were 95, 94, 43, and 46%, respectively. The specificities of the Hybrid Capture assay and antigenemia were 95 and 94%, respectively. At all three study sites, the detected level of CMV viremia was significantly higher with the Hybrid Capture assay or antigenemia than with shell vial and tube culture. In a group of 131 healthy nonimmunosuppressed volunteers, the Hybrid Capture assay demonstrated a specificity of over 99%. The Hybrid Capture assay is a standardized assay that is simple to perform and can utilize whole blood specimens that have been stored for up to 48 h. The high sensitivity and specificity of the Hybrid Capture assay along with its simplicity and flexibility make it a clinically useful assay for the detection of CMV viremia in immunocompromised or immunosuppressed patients. Further evaluation to determine its role in predicting CMV disease and for monitoring the therapeutic response to anti-CMV therapy is needed.  (+info)

Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty. (8/3452)

BACKGROUND: Restenosis is a common problem after all revascularization procedures in atherosclerotic coronary arteries. Reactivated human cytomegalovirus (CMV) has been detected in tissues of restenotic vascular lesions and was hypothesized to be a contributing pathogenic factor. Recent data suggest an association of restenosis after optimal coronary atherectomy with CMV serostatus, and a possible role of antiviral therapy was discussed. We therefore tested the hypothesis that prior CMV infection might be a risk factor for restenosis after conventional coronary balloon angioplasty (PTCA). METHODS AND RESULTS: We analyzed 92 consecutive patients who had been admitted for control angiography after previous PTCA within a mean interval of 6 months. Anti-CMV antibodies were measured as an indicator of prior CMV infection and latency. The coronary angiograms before PTCA, directly after, and 6 months later were analyzed quantitatively. Sixty-five percent of the patients were CMV-positive. Before PTCA, the degree (mean+/-SD) of stenosis was 69+/-10% in CMV-positive and 68+/-8.3% in CMV-negative subjects. PTCA resulted in a residual stenosis of 39% in both groups. After 6 months, the late losses of luminal diameter in the CMV-positive and -negative groups were 11+/-13% and 12+/-15%, respectively (P=0.658). In an ANCOVA with 25 potential risk factors for restenosis, CMV serostatus was not significantly associated with restenosis development. CONCLUSIONS: Our data indicate that prior CMV infection, in contrast to optimal atherectomy, is not associated with chronic restenosis after conventional coronary balloon angioplasty. The results do not support a possible benefit from antiviral therapy.  (+info)

Use of the Cytomegalovirus (CMV) Antigenemia Assay for the Rapid Diagnosis of Primary CMV Infection in Hospitalized Adults :...Use of the Cytomegalovirus (CMV) Antigenemia Assay for the Rapid Diagnosis of Primary CMV Infection in Hospitalized Adults :...
We assessed the value of the cytomegalovirus (CMV) antigenemia assay for diagnosing primary CMV infection in adults. The CMV antigenemia assay was performed for 40 patients admitted to our unit over a 2-year period with unexplained fever and suspected primary CMV infection. Nine of the 10 patients with primary CMV infection had positive CMV antigenemia assays, and the results were available within 5 hours. All 10 patients had a mononucleosis-like syndrome. All but one of the 30 other patients had negative CMV antigenemia assays. A false-positive result was obtained for a patient with systemic lupus erythematosus. Overall, the CMV antigenemia assay was 90% sensitive and 96% specific for the diagnosis of primary CMV infection. Therefore, the CMV antigenemia assay appears to be a simple, rapid, inexpensive test for the diagnosis of primary CMV infection in hospitalized adults.. ...
Neurodevelopmental assessment after congenital cytomegalovirus infection. | Archives of Disease in ChildhoodNeurodevelopmental assessment after congenital cytomegalovirus infection. | Archives of Disease in Childhood
The neurodevelopmental state of 41 children with congenital cytomegalovirus infection and their controls was assessed at 2 years using the Griffiths scale. The scores achieved by children with congenital cytomegalovirus but with no associated neurological abnormality (asymptomatic) were similar to those of the control children, whereas the mean score of the five children with congenital infection and neurological impairment (symptomatic) was significantly lower. This study, which has the statistical power to detect differences in developmental quotient as small as five points, gave no evidence that at 2 years cytomegalovirus infection was associated with mental retardation in the absence of other neurological impairment. Thus 90% of children with congenital cytomegalovirus infection at 2 years are neurologically and developmentally normal.. ...
FULL TEXT - Primary cytomegalovirus infection presenting with itching and obstetric cholestasis like picture in mid-trimester -...FULL TEXT - Primary cytomegalovirus infection presenting with itching and obstetric cholestasis like picture in mid-trimester -...
We present a case of Primary cytomegalovirus infection presented in mid-trimester with itching and obstetric cholestasis like picture. To the best of our knowledge the similarities between primary CMV and obstetric cholestasis, when presenting during pregnancy, have not been highlighted before in the literature. Case Report: A 36 year old lady presented to antenatal clinic at 23+4 weeks gestational age with intense itching. Bile acids and ALT were raised so she was treated as obstetric cholestasis whilst other results were awaited. Cytomegalovirus (CMV) antibodies, immunoglobulin G (IgG) and IgM were positive despite being negative at booking, suggesting an acquisition of CMV at approximately 18 weeks gestation. This article highlights the details of her case including the management and consequences of cytomegalovirus in pregnancy. Conclusion: This case report highlights the importance of the awareness of the clinicians with the condition as a differential diagnosis to obstetric cholestasis. CMV should
Acute cytomegalovirus (CMV) infection. Causes, symptoms, treatment Acute cytomegalovirus (CMV) infectionAcute cytomegalovirus (CMV) infection. Causes, symptoms, treatment Acute cytomegalovirus (CMV) infection
Description of disease Acute cytomegalovirus (CMV) infection. Treatment Acute cytomegalovirus (CMV) infection. Symptoms and causes Acute cytomegalovirus (CMV) infection Prophylaxis Acute cytomegalovirus (CMV) infection
Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver...Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver...
TY - JOUR. T1 - Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver transplantation. AU - Sia, Irene G.. AU - Wilson, Jennie A.. AU - Espy, Mark J.. AU - Paya, Carlos V.. AU - Smith, Thomas F.. PY - 2000/2/16. Y1 - 2000/2/16. N2 - Detection of cytomegalovirus (CMV) DNA in blood by PCR is a sensitive method for the detection of infection in patients posttransplantation. The test, however, has low specificity for the identification of overt CMV disease. Quantitative CMV PCR has been shown to overcome this shortcoming. The COBAS AMPLICOR CMV MONITOR test was evaluated by using consecutive serum and peripheral blood mononuclear cell (PBMN) samples from liver transplant patients. Twenty-five patients had CMV viremia (by shell vial cell culture assay) and/or tissue-invasive disease (by biopsy); 20 had no active infection. A total of 262 serum and 62 PBMN specimens were tested. Of 159 serum specimens from patients with overt CMV ...
Human Cytomegalovirus Infection: Biological Features, Transmission, Symptoms, Diagnosis, and Treatment | IntechOpenHuman Cytomegalovirus Infection: Biological Features, Transmission, Symptoms, Diagnosis, and Treatment | IntechOpen
Human cytomegalovirus (CMV), a member of the human herpesviruses, is a deoxyribonucleic acid virus that is ubiquitous in the world. After primary infection, CMV develops a latent state; however, when the defense of the immune system decreases in a host, it can reactivate. Human cytomegalovirus infections are acquired via several ways. CMV is spread through contact with infected bodily fluids in humans, whereas it occurs in pregnant women through close contact with young children or through sexual transmission. The clinical manifestations consist of non-specific symptoms or clinical findings. However, the patients with acute CMV infections are generally asymptomatic. Congenital CMV infection (present at birth) occurs via intrauterine transmission of the virus that is thought to be transferred to the developing fetus. The common clinical manifestations of congenital CMV infection are sensorineural hearing loss, petechiae, jaundice at birth, and hepatosplenomegaly. The vast majority of healthy children and
The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusThe outcome of congenital cytomegalovirus infection in relation to maternal antibody status
Background. Intrauterine transmission of cytomegalovirus (CMV) can occur whether a mother has prior immunity or acquires CMV for the first time during pregnancy. The degree of protection afforded an infected infant by the presence of antibody in the mother before conception is uncertain. Methods. We compared the outcomes of CMV-infected infants born to mothers who acquired primary CMV infection during pregnancy (primary-infection group) with those of CMV-infected infants born to mothers with immunity (recurrent-infection group). Screening for viruria identified 197 newborns with congenital CMV infection. Stored serum samples were used to categorize maternal infection as either primary or recurrent. We followed 125 infants from the primary-infection group and 64 from the recurrent-infection group. Serial medical, audiologic, psychometric, and eye examinations were used to identify sequelae of CMV infection. Results. Only infants in the primary-infection group had symptomatic CMV infection at ...
Cytomegalovirus infection | Article about cytomegalovirus infection by The Free DictionaryCytomegalovirus infection | Article about cytomegalovirus infection by The Free Dictionary
Looking for cytomegalovirus infection? Find out information about cytomegalovirus infection. A common asymptomatic infection caused by cytomegalovirus, which can produce life-threatening illnesses in the immature fetus and in immunologically... Explanation of cytomegalovirus infection
The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients: The...The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients: The...
TY - JOUR. T1 - The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients. T2 - The Wisconsin Allograft Recipient Database. AU - Astor, Brad C.. AU - Djamali, Arjang. AU - Mandelbrot, Didier A.. AU - Parajuli, Sandesh. AU - Melamed, Michal L.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background. Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in kidney transplant recipients. Vitamin D has an integral role in proper immune function, and deficiency is common among kidney transplant recipients. It remains unclear whether 25-hydroxyvitamin D [25(OH)D] level is associated with CMV infection in kidney transplant recipients. Methods. We examined the relationship between 25(OH)D levels, measured at least 6 months posttransplant, and subsequent CMV infection in 1976 recipients free of prior CMV infection. Results. Of 1976 recipients, 251 (12.7%) were vitamin D deficient [25(OH)D ,20 ng/mL] and 548 (27.7%) were insufficient ...
Donor and recipient CMV serostatus and antigenemia after renal transplantation: an analysis of 486 patients. - Nuffield...Donor and recipient CMV serostatus and antigenemia after renal transplantation: an analysis of 486 patients. - Nuffield...
BACKGROUND: Cytomegalovirus infection in renal transplant recipients is a major clinical problem, with both short and long term sequelae. Infection can occur as a result of reactivation of latent virus or new infection from donor tissues. The impact of donor and recipient serostatus on viremia is well recognised, with seronegative recipients at greatest risk after transplantation of an organ from a seropositive donor. However, the impact of grafting such organs into seropositive recipients is less clear. OBJECTIVES: To assess the impact of recipient serostatus on the risk of CMV antigenemia in a large renal transplant cohort. STUDY DESIGN: We prospectively quantified CMV antigenemia over time in a cohort of 486 recipients. We analysed the antigenemia status according to donor and recipient serostatus. RESULTS: Antigenemia was most common in seronegative recipients of organs from seropositive donors (D+/R-). Nevertheless, we observed that even in CMV seropositive recipients, the impact of donor
Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: A systematic review and...Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: A systematic review and...
TY - JOUR. T1 - Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis. T2 - A systematic review and meta-Analysis. AU - Kalil, Andre C. AU - Mindru, Cezarina. AU - Botha, Jean F.. AU - Grant, Wendy J.. AU - Mercer, David F. AU - Olivera-Martinez, Marco A. AU - McCartan, Megan A.. AU - McCashland, Timothy M. AU - Langnas, Alan Norman. AU - Florescu, Diana F. PY - 2012/12/1. Y1 - 2012/12/1. N2 - Valganciclovir (VGC) was approved by the Food and Drug Administration in 2004 as cytomegalovirus (CMV) prophylaxis except for liver transplant recipients because of their high incidence of CMV disease with this drug. However, surveys have shown its common off-label use for CMV prophylaxis in liver transplant recipients. We aimed to evaluate the risk of CMV disease with VGC prophylaxis in liver transplant recipients. All studies that evaluated liver transplant recipients and used VGC (900 or 450 mg daily) for the prevention of CMV disease were included. Five ...
GastroHep News StoryGastroHep News Story
The researchers found that anti-cytomegalovirus IgG and IgM were positive in 66% and 5% of patients respectively.. In addition, the research team found blood or urine cytomegalovirus replication markers in 6% of patients, all of whom had ulcerative colitis.. 3 patients had cytomegalovirus viremia and received anti-viral treatment with ganciclovir.. The researchers noted that only 1 of these patients had cytomegalovirus antigenemia and also associated biopsy-proven cytomegalovirus colitis, probably as a primary cytomegalovirus infection.. This patient is the only one who benefited from anti-viral therapy.. Prof Bouhnik concluded, "Cytomegalovirus infection is infrequent in in-patients with active inflammatory bowel disease.". "Systematic search of cytomegalovirus replication markers should not be performed.". "Isolated viremia without associated antigenemia or direct demonstration of cytomegalovirus in ileocolonic biopsies does not warrant anti-viral therapy.". ...
Neutropenia and congenital cytomegalovirus infectionNeutropenia and congenital cytomegalovirus infection
article{df027303-d823-4a01-840a-7bebb6a9e463, author = {Ivarsson, Sten A. and Ljung, Rolf}, issn = {0891-3668}, language = {eng}, number = {6}, pages = {436--437}, publisher = {Lippincott Williams & Wilkins}, series = {Pediatric Infectious Disease Journal}, title = {Neutropenia and congenital cytomegalovirus infection}, volume = {7}, year = {1988 ...
A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) - Full Text View - ClinicalTrials.govA Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) - Full Text View - ClinicalTrials.gov
Cytomegalovirus (CMV) is the most common congenital infection, with approximately 44,000 congenitally infected infants in the U.S. per year. A substantial proportion of these infants will die or suffer permanent injury as a result of their infection. The severity of congenital infection is greatest with primary maternal CMV infection. Currently, there is no proven method of preventing congenital CMV infection, and the approach to primary maternal CMV infection in the United States is haphazard and ineffective. One small, non-randomized study suggests that maternal administration of CMV hyperimmune globulin may significantly reduce the rate of congenital CMV infection following maternal primary infection. The MFMU CMV Trial will address the primary research question: does maternal administration of CMV hyperimmune globulin lower the rate of congenital CMV infection among the offspring of women who have been diagnosed with primary CMV infection during early pregnancy?. The research study is funded ...
Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients...Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients...
TY - JOUR. T1 - Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood. AU - Della Chiesa, Mariella. AU - Falco, Michela. AU - Bertaina, Alice. AU - Muccio, Letizia. AU - Alicata, Claudia. AU - Frassoni, Francesco. AU - Locatelli, Franco. AU - Moretta, Lorenzo. AU - Moretta, Alessandro. PY - 2014/2/15. Y1 - 2014/2/15. N2 - NK cells are the first lymphoid population recovering after allogeneic hematopoietic stem cell transplantation and play a crucial role in early immunity after the graft. Recently, it has been shown that humanCMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical cord blood transplantation by accelerating the differentiation of mature NKG2A-killer Ig-like receptor (KIR)+ NK cells characterized by the expression of the NKG2C-activating receptor. In view of the hypothesis that NKG2C could be directly involved in NK cell ...
Prevention of active cytomegalovirus infection and disease in kidney transplant recipientsPrevention of active cytomegalovirus infection and disease in kidney transplant recipients
Cytomegalovirus (CMV) is a globally widespread virus that becomes latent following primary infection but reactivates frequently and, in the setting of immunocompromise, causes disease in solid organ transplant patients, including kidney transplant re
Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease -- Staunton et al. ...Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease -- Staunton et al. ...
A 26-week-gestation infant developed cystic lung changes which required lobar resection at 6 weeks of age. Lung histology showed cytomegalovirus (CMV) inclusion bodies. The authors present the radiology and histology images of this case and review the literature regarding congenital CMV infection and cystic lung disease. Lung disease caused by CMV is typically a diffuse pneumonitis. This is the first reported case of congenital CMV infection causing emphysematous lung disease to develop in the neonatal period. The case raises awareness of CMV as a possible cause of cystic lung lesions in newborns. ...
Community Engagement to Improve Prevention and Treatment of Congenital Cytomegalovirus Infection - Tier I | PCORICommunity Engagement to Improve Prevention and Treatment of Congenital Cytomegalovirus Infection - Tier I | PCORI
Congenital cytomegalovirus (CMV) infection is a significant cause of infant morbidity and a high national priority for development of prevention and treatment strategies. CMV is the most common congenital infection, with incidence of approximately 0.7 percent of live births in the United States (30,000 or 1:150 infants/year). Nearly 20 percent exhibit permanent neurologic disabilities, including hearing loss and severe cognitive or physical impairment.
Differential Impact of Age and Cytomegalovirus Infection on the γδ T Cell Compartment | The Journal of ImmunologyDifferential Impact of Age and Cytomegalovirus Infection on the γδ T Cell Compartment | The Journal of Immunology
Aging is associated with significant alterations of both the adaptive and innate arms of the immune system. The present study focuses on γδ T cells, which are considered intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age. We show that both aging and CMV infection impact independently on the γδ T cell compartment. This dual effect provides an explanation for the discrepancy in the changes observed between Vδ2− and Vδ2+ γδ T cells in elderly (10, 11). Although the frequency of Vδ2+ γδ T cells declines in all individuals with advanced age, Vδ2− γδ T cell numbers only decrease in CMV-seronegative donors. In CMV-seropositive donors, the frequency of Vδ2− γδ T cells is likely preserved overtime as the result of the strong mobilization of the Vδ2− γδ T cell pool because of persistent CMV infection. This phenomenon is reminiscent of the so ...
Merck begins Phase III letermovir trial for prevention of CMV infection - Drug Development TechnologyMerck begins Phase III letermovir trial for prevention of CMV infection - Drug Development Technology
US-based pharmaceutical firm Merck has enrolled the first patient in a global Phase III clinical trial of letermovir (MK-8228), an investigational antiviral agent, for prevention of cytomegalovirus (CMV) infection in high-risk bone marrow transplant patients.. The trial will assess the efficacy and safety of letermovir for the prevention of clinically-significant CMV infection in adults aged 18 years and older CMV-seropositive recipients of allogeneic hematopoietic stem cell transplants.. Letermovir is being developed for the prevention of human CMV infection and has secured orphan product designation from the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the prevention of CMV viremia.. Merck Research Laboratories Infectious Diseases executive director Michele Trucksis said: There remains a need for additional therapeutic options in the prevention of CMV infection in high-risk patients.. Merck is pleased to initiate this global Phase III study with ...
Intrauterine fetal death due to congenital cytomegalovirus infection | The Brazilian Journal of Infectious DiseasesIntrauterine fetal death due to congenital cytomegalovirus infection | The Brazilian Journal of Infectious Diseases
Congenital CMV infection results from transplacental transmission of the virus during maternal viremia. The fetus can be infected by either a newly acquired (primary) maternal infection or a recurrent (reactivated) maternal infection. The likelihood of fetal infection and the risk of associated damage and sequelae are higher after a primary infection. Maternal viremia is more likely to occur at primary than recurrent infection.1 After transplacental transmission, the virus spreads through the fetus by hematogenous route. Infection at an earlier gestational age often correlates with a worse outcome and may lead to intrauterine death.2. Cytomegalovirus is a DNA virus of the herpesvirus group which produces an enlargement of the infected cell, and microscopically with hematoxylin-eosin staining, a large 5-15μm sized violaceous to dark red intranuclear inclusion surrounded by a thin clear halo can be seen. At autopsy, diagnosis is most often made histologically by finding the characteristic CMV ...
CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays | BMC Infectious Diseases ...CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays | BMC Infectious Diseases ...
CMV is a major clinical problem in transplant recipients. Thus, it is important to use sensitive and specific diagnostic techniques to rapidly and accurately detect CMV infection and identify patients at risk of developing CMV disease. In the present study, CMV infection after liver transplantation was monitored retrospectively by two molecular biology assays - a quantitative PCR assay and a qualitative NASBA assay. The results were compared with those obtained by prospective pp65 antigenemia determinations. 87 consecutive samples from 10 liver transplanted patients were tested for CMV by pp65 antigenemia, and CMV monitor and NASBA pp67 mRNA assay. CMV infection was detected in all patients by antigenemia and CMV monitor, whereas NASBA assay identified only 8/10 patients with viremia. Furthermore, CMV infection was never detected earlier by molecular biology assays than by antigenemia. Only 5/10 patients with CMV infection developed CMV disease. Using a cut off value of 8 cells/50,000, antigenemia was
Cytomegalovirus in female patients attending a VD clinic. | Sexually Transmitted InfectionsCytomegalovirus in female patients attending a VD clinic. | Sexually Transmitted Infections
A study of 531 female patients attending a venereal disease clinic was undertaken to assess the incidence of cytomegalovirus (CMV) in the cervix. The findings were as follows: (1) 35 of 531 patients had positive cervical cultures for CMV (6-6 per cent.). (2) 28 of 531 patients were positive for Herpes virus hominis (5-3 per cent.). (3) Excluding those who were pregnant, 20 of 28 with CMV were taking oral contraceptives (71 per cent.). (4) Seven babies born to infected mothers showed no signs of cytomegalic inclusion disease. (5) 28 of 35 with CMV had associated genital infections (80 per cent.). (6) Positive cultures were obtained in twenty cases for periods up to 10 months. (7) The CMV complement-fixation test was positive in all 23 patients with positive CMV cultures who were tested. (8) Seven male consorts were examined but CMV was not isolated from any of them. (9) A case of CMV mononucleosis was detected. It is suggested that the higher incidence in patients attending a VD clinic is due to ...
Multicity Italian study of congenital cytomegalovirus infection - UnissResearchMulticity Italian study of congenital cytomegalovirus infection - UnissResearch
Methods: Diagnosis of congenital CMV infection was sought in 9032 children born between March 2002 and February 2003 by testing for viral DNA [CMV dried blood spot (DBS) test] in each newborns Guthrie card and confirmation by isolation of CMV from urine collected in the first 3 weeks of life; CMV IgG testing in 1200 women of childbearing age; clinical and audiologic tests in the first 24 months for infected children; CMV DBS tests on the Guthrie cards collected from screening centers for 77 children (3 months-5 years) presenting SNHL of 40 dB or more ...
Congenital and perinatal cytomegalovirus infection in infants born to mothers infected with human immunodeficiency virusCongenital and perinatal cytomegalovirus infection in infants born to mothers infected with human immunodeficiency virus
Objectives: To determine the rates of congenital and perinatal cytomegalovirus (CMV) infection among infants born to mothers infected with HIV compared with infants born to mothers not infected with HIV from a CMV-immune, low-income population.Study design: A total of 325 newborns from CMV-seropositive mothers were enrolled and evaluated for congenital CMV infection (150 infants from HIV+ mothers and 175 infants from HIV- mothers. A total of 101 infants from HIV+ mothers and 33 infants from HIV- mothers were evaluated for perinatal CMV infection. the virus was isolated from urine by culture in human fibroblasts and was detected by polymerase chain reaction at birth and at 15 days and 12 weeks of age.Results: Only 13 of 150 HIV+ mothers (8.7%) had an AIDS-defining condition, and none had a late-stage HIV infection. Congenital CMV infection was detected in 4 of 150 (2.7%) infants from HIV+ mothers and in 5 of 175 (2.9%) infants from HIV- mothers (p = 1.00). Perinatal CMV infection was diagnosed in ...
Letermovir succeeds in CMV prevention after HSCT in latest trial. ecancer - NewsLetermovir succeeds in CMV prevention after HSCT in latest trial. ecancer - News
05 Apr 2017. Results of the pivotal Phase 3 clinical study of letermovir, an investigational antiviral medicine for the prevention of clinically-significant cytomegalovirus (CMV) infection in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT) have been announced.. The results were presented for the first time at the BMT Tandem Meetings, the combined annual meetings of the Center for International Blood & Marrow Transplant Research (CIBMTR) and the American Society for Blood and Marrow Transplantation (ASBMT).. CMV is the most common clinically significant viral infection in allogeneic HSCT recipients.. While preemptive therapy (treatment when CMV DNA is detected in the blood) with antiviral medicines can reduce the incidence of CMV disease, CMV reactivation post-HSCT is associated with higher mortality despite the use of preemptive therapy.. Letermovir is an investigational once-daily antiviral medicine under development for the prevention of CMV ...
Vertical Cytomegalovirus Transmission From HIV-Infected Women Randomized to Formula-Feed or Breastfeed Their Infants. | PROF....Vertical Cytomegalovirus Transmission From HIV-Infected Women Randomized to Formula-Feed or Breastfeed Their Infants. | PROF....
Richardson BA, John-Stewart G, Atkinson C, Ruth Nduati, Ásbjörnsdóttir K, Boeckh M, Overbaugh J, Emery V, Slyker JA. "Vertical Cytomegalovirus Transmission From HIV-Infected Women Randomized to Formula-Feed or Breastfeed Their Infants." J. Infect. Dis.. 2016;213(6):992-8 ...
A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients - Full Text View - ClinicalTrials.govA Study of CMV Vaccine (HB-101) in Kidney Transplant Patients - Full Text View - ClinicalTrials.gov
This is a randomized, placebo-controlled, phase 2 study to assess the safety, reactogenicity, immunogenicity, and efficacy of HB-101 in adult patients awaiting kidney transplantation. For Groups 1 and 2, adult CMV-seronegative (-) patients awaiting kidney transplant from a CMV-seropositive (+) living donor will be enrolled according to treatment intent with regard to the method of CMV prevention after transplant (either preemptive or prophylactic). This will be defined at study enrollment by the investigator and institutional standards. Patients enrolled in Group 1 and 2 will be randomized to receive HB-101 or placebo. For Group 3, adult CMV-seropositive (+) patients awaiting kidney transplant from either CMV-seropositive(+) or CMV-seronegative(-) living donors will be enrolled. Group 3 will be open label where all patients will receive HB-101. The post transplant management for Group 3 patients will also follow either preemptive or prophylactic method per the institution standards. The intent ...
Biotech and Pharma 3 | Biotechnology Pharma NewsBiotech and Pharma 3 | Biotechnology Pharma News
KENILWORTH, N.J.--(BUSINESS WIRE)--Merck & Co., Inc. (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved PREVYMIS™ (letermovir) once-daily tablets for oral use and injection for intravenous infusion. PREVYMIS is indicated for prophylaxis (prevention) of cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT). CMV is a common and potentially serious viral infection in allogeneic HSCT recipients. CMV-seropositive patients who undergo an HSCT are at high risk for CMV reactivation. Any level of CMV infection is associated with increased mortality in HSCT patients. In the pivotal Phase 3 clinical trial supporting approval, significantly fewer patients in the PREVYMIS group (38%, n=122/325) compared to the placebo group (61%, n=103/170) developed clinically significant CMV infection, discontinued treatment or had missing ...
Fatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and ThymomaFatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and Thymoma
Prenatal serological diagnosis of intrauterine cytomegalovirus infection. Lange, I.; Rodeck, C.H.; Morgan-Capner, P.; Simmons, A.; Kangro, H.O. // British Medical Journal (Clinical Research Edition);6/5/1982, Vol. 284 Issue 6330, p1673 Examines the prenatal serological diagnosis of intrauterine cytomegalovirus infection in a rhesus-positive woman. Observation of a single fetus with gross ascites in an ultrasound scan; Findings of hypoalbuminemia on the fetal serum; Antibody titre during the initial serology for cytomegalovirus. ...
Ganciclovir--a review of pharmacology, therapeutic efficacy and potential use for treatment of congenital cytomegalovirus...Ganciclovir--a review of pharmacology, therapeutic efficacy and potential use for treatment of congenital cytomegalovirus...
Ganciclovir--a review of pharmacology, therapeutic efficacy and potential use for treatment of congenital cytomegalovirus infections
Congenital Cytomegalovirus Infection: Time to Test Newborns? - ENTtodayCongenital Cytomegalovirus Infection: Time to Test Newborns? - ENTtoday
Experts weigh in on expanding state newborn screening panels to include CMV infection, a common non-genetic cause of sensorineural hearing loss in children
Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus...Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus...
Objective. To determine whether newborn cranial computed tomographic (CT) scan abnormalities predict an adverse neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection and to examine the association between clinical findings at birth and imaging abnormalities.. Methods. The data from 56 children with symptomatic congenital CMV infection who underwent cranial CT scans as newborns and were enrolled in a long-term follow-up study were analyzed. The incidence of sequelae was compared between the groups of children with normal and abnormal imaging studies. The relationship between CT scan results and other newborn findings was also examined.. Results. Abnormal CT scans were noted in 70% of subjects; intracerebral calcification was the most frequent finding. Most of the children with an abnormal newborn CT scan (90%) developed at least one sequela, compared with 29% of those with a normal study. Only 1 child with a normal CT scan had an IQ ,70, in contrast to ...
Cerebellar hypoplasia in an infant with congenital cytomegalovirus infectionCerebellar hypoplasia in an infant with congenital cytomegalovirus infection
The pathologic changes noted in the brain of micropolygyria, periventricular calcifications, and chronic inflammation have long been regarded as the hallmarks of chronic CMV infection of the fetal brain. However, the presence of striking cerebellar hypoplasia, reminiscent of some viral infections of the central nervous system described in the experimental animal models, has prompted this short communication ...
Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy | Springer for Research &...Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy | Springer for Research &...
Background Cytomegalovirus infection dramatically decreased with the introduction of antiretroviral therapy. Whether incidence, clinical characteristics and prognosis of cytomegalovirus in HIV...
Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionDried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection
Among newborns, CMV testing with DBS real-time PCR compared with saliva rapid culture had low sensitivity, limiting its value as a screening test.
Faecal Microbiota Transfer - a new concept for treating cytomegalovirus colitis in children with ulcerative colitisFaecal Microbiota Transfer - a new concept for treating cytomegalovirus colitis in children with ulcerative colitis
Introduction: Cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD) is reactivated by the use of immunosuppressive drugs. CMV infection may produce IBD flares refractory to standard therapy. Objective: The aim of our study was to assess the efficacy and safety of...
Cytomegalovirus in transplantation - challenging the status quo - Fishman - 2006 - Clinical Transplantation - Wiley Online...Cytomegalovirus in transplantation - challenging the status quo - Fishman - 2006 - Clinical Transplantation - Wiley Online...
Abstract: Background: Cytomegalovirus (CMV) infection of solid organ transplant (SOT) recipients causes both direct and indirect effects including allograft rejection, decreased graft and patient survival, and predisposition to opportunistic infections and malignancies. Options for CMV prevention include pre-emptive therapy, whereby anti-CMV agents are administered based on sensitive viral assays, or universal prophylaxis of all at-risk patients. Each approach has advantages and disadvantages in terms of efficacy, costs, and side effects. Standards of care for prophylaxis have not been established.. Methods: A committee of international experts was convened to review the available data regarding CMV prophylaxis and to compare preventative strategies for CMV after transplantation from seropositive donors or in seropositive recipients.. Results: Pre-emptive therapy requires frequent monitoring with subsequent treatment of disease and associated costs, while universal prophylaxis results in ...
Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus Infection - Experts@MinnesotaOptimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus Infection - [email protected]
Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint. ...
Healthcare costs attributable to congenital cytomegalovirus infection | Archives of Disease in ChildhoodHealthcare costs attributable to congenital cytomegalovirus infection | Archives of Disease in Childhood
Contributors Study concept and design: HEdM, MJK, AMO-M and ACTMV. Acquisition, analysis or interpretation of data: MJK, MW, MEvdA-vM, HEdM and ACTMV. Drafting of the manuscript: MJK and MW. Critical revision of the manuscript for important intellectual content: MJK, MW, MEvdA-vM, AMO-M, HEdM and ACTMV. Statistical analysis: MJK, MW and MEvdA-vM. Obtaining funding: HEdM. Administrative, technical or material support: MJK and MW. Supervision: HEdM, AMO-M and ACTMV. ...
Jennifer Slyker, PhD, Assistant Professor, Department of Global Health - Kenya Research ProgramJennifer Slyker, PhD, Assistant Professor, Department of Global Health - Kenya Research Program
Publications:. Slyker JA, Lohman-Payne BL, John-Stewart, GC, Obimbo E, Emery S, Richardson BA, Dong T, Iversen A, Mbori-Ngacha D, Overbaugh J, Emery VC, Rowland-Jones SL. Acute cytomegalovirus infection in Kenyan HIV-1 infected infants. AIDS 2009, 23: 2173-2181. A commentary on this article was published in the same issue: "HIV and cytomegalovirus co-infection in congenitally infected children: copathogens fanning each others flames?" Schleiss, M. AIDS 2009, 23: 2215-2217.. Lohman-Payne B, Slyker JA, Richardson BA, Farquhar C, Majiwa M, Obimbo E, Mbori-Ngacha D, Overbaugh J, Rowland-Jones SL, John-Stewart GC. HIV-1 specific interferon-gamma responses in infants with early peripartum infection compared to late breastmilk infection. Clinical and Experimental Immunology 2009, 156:511-7.. John-Stewart GC, Mbori-Ngacha D, Lohman-Payne BL, Farquhar C, Emery S, Otieno P, Obimbo, E, Richardson BA, Dong T, Slyker JA, Nduati R, Overbaugh J, Rowland-Jones SL. HIV-1 specific CTLs and Breastmilk HIV-1 ...
A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic,...A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic,...
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...
Diagnosis of cytomegalovirus infection (CMV): Costs for treatment #210459 in Germany | BookingHealthDiagnosis of cytomegalovirus infection (CMV): Costs for treatment #210459 in Germany | BookingHealth
Diagnosis of cytomegalovirus infection (CMV) (costs for program #210459) ✔ Charite University Hospital Berlin ✔ Department of Pediatric Gastroenterology and Metabolic Medicine ✔ BookingHealth.com
Diagnosis of cytomegalovirus infection (CMV): Costs for treatment #242625 in Germany | BookingHealthDiagnosis of cytomegalovirus infection (CMV): Costs for treatment #242625 in Germany | BookingHealth
Diagnosis of cytomegalovirus infection (CMV) (costs for program #242625) ✔ University Hospital Hamburg-Eppendorf ✔ Department of Pediatrics ✔ BookingHealth.com
Cytomegalovirus infection after autografting for hematologic malignancies: Clinical significance and lack of effect on...Cytomegalovirus infection after autografting for hematologic malignancies: Clinical significance and lack of effect on...
Singhal, S, Powles, R, Treleaven, J, Horton, C, Jameson, B, Pinkerton, CR, Meller, S and Mehta, J (1996). Cytomegalovirus infection after autografting for hematologic malignancies: Clinical significance and lack of effect on engraftment.. In: British Journal of Haematology. , , (139-139). . ...
Cytomegalovirus Infections Clinical Research Trials | CenterWatchCytomegalovirus Infections Clinical Research Trials | CenterWatch
Cytomegalovirus Infections Clinical Research Trial Listings in Immunology Pediatrics/Neonatology Family Medicine Infections and Infectious Diseases on CenterWatch
New Medical Therapies Trial Results in Cytomegalovirus Infections | CenterWatchNew Medical Therapies Trial Results in Cytomegalovirus Infections | CenterWatch
Our New Medical Therapies(TM) Trial Results database provides a snapshot of results from completed and ongoing clinical trials, based on published materials from medical conferences, journals and CenterWatch reports. View Cytomegalovirus Infections clinical trial results here.
Cytomegalovirus infection as a cause of ileoanal pouchitis | SpringerLinkCytomegalovirus infection as a cause of ileoanal pouchitis | SpringerLink
1.. Munoz-Juarez M, Pemberton, JH, Sandborn WJ, Tremaine WJ, Dozois RR. Misdiagnosis of specific cytomegalovirus infection of the ileoanal pouch as refractory idiopathic chronic pouchitis. Dis Colon Rectum 1999;42:117-20.. ...
Cytomegalic inclusion disease | definition of cytomegalic inclusion disease by Medical dictionaryCytomegalic inclusion disease | definition of cytomegalic inclusion disease by Medical dictionary
Looking for online definition of cytomegalic inclusion disease in the Medical Dictionary? cytomegalic inclusion disease explanation free. What is cytomegalic inclusion disease? Meaning of cytomegalic inclusion disease medical term. What does cytomegalic inclusion disease mean?
Possible triggering effect of cytomegalovirus infection on systemic lupus erythematosus<...Possible triggering effect of cytomegalovirus infection on systemic lupus erythematosus<...
TY - JOUR. T1 - Possible triggering effect of cytomegalovirus infection on systemic lupus erythematosus. AU - Nawata, M.. AU - Seta, N.. AU - Yamada, M.. AU - Sekigawa, I.. AU - Iida, N.. AU - Hashimoto, H.. PY - 2001. Y1 - 2001. N2 - We report on a patient with systemic lupus erythematosus (SLE) who showed elevated titers of IgM antibodies to cytomegalovirus (CMV), suggesting CMV infection at the onset of SLE. Serum CMV antigens were also detected in the patient. These findings raise the possibility that CMV infection may be related to the onset of SLE in certain patients.. AB - We report on a patient with systemic lupus erythematosus (SLE) who showed elevated titers of IgM antibodies to cytomegalovirus (CMV), suggesting CMV infection at the onset of SLE. Serum CMV antigens were also detected in the patient. These findings raise the possibility that CMV infection may be related to the onset of SLE in certain patients.. KW - Cytomegalovirus. KW - Proteinuria. KW - Systemic lupus ...
Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient<...Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient<...
TY - JOUR. T1 - Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient. AU - Ardalan, M.. AU - Mohajel Shoja, Mohammadali. PY - 2009/9/1. Y1 - 2009/9/1. N2 - Cytomegalovirus (CMV) is an important pathogen in organ-transplant recipients. There have been frequent reports of CMV-induced adrenal insufficiency in patients with human immunodeficiency virus infection. Herein, we report CMV-induced renal insufficiency in a renal transplant recipient. A 24-year-old woman had gradual onset of weakness, anorexia, nausea, hypotension, and skin hyperpigmentation at 5 months after renal transplantation. The immunosuppression regimen included cyclosporine, mycophenolate mofetil, and corticosteroid (prednisolone, 5 mg/d). Recent history included acute CMV infection, which was treated with ganciclovir. Basal serum cortisol concentration was 4 μg/dL, and stimulated serum cortisol concentration was less than 10 μg/dL. All clinical signs and symptoms and hypotension gradually improved after ...
New Insights Into Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplant - Hematology & OncologyNew Insights Into Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplant - Hematology & Oncology
H&O How common is CMV infection among patients undergoing allogeneic hematopoietic stem cell transplant?. MB Cytomegalovirus (CMV) reactivation occurs in approximately 50% to 70% of seropositive patients undergoing allogeneic transplant. The rate varies depending on the diagnostic method that is used to identify reactivation. Among settings in which the donor is seropositive and the recipient is negative, the incidence is 20% to 25% (Figure).. H&O What risk factors have been identified for CMV reactivation and the development of CMV infection?. MB The CMV serostatus is important, with CMV seropositivity of the recipient being the highest-risk setting. CMV donor serostatus can affect the severity of CMV infection among seropositive recipients. However, even if both the donor and the recipient are seronegative and "CMV-safe" blood is used, CMV infection occurs in approximately 1% of patients. The conditioning regimen, including T-cell depletion, can affect the risk of reactivation, the viral load ...
Cytomegalovirus review articleCytomegalovirus review article
Original Article. Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the prenatal period. Ster, B.... Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2, Epstein Barr virus, and varicella zoster virus. Vid W. Chronic inflammation may be a causative factor in a variety of cancers. Mberlin, M. Review. Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the prenatal period. General, the longer the inflammation persists, the higher the risk of cancer. Systematic review of publications indexed in the PubMed database was performed for HSCT studies. General, the longer the inflammation persists, the higher the risk of cancer. 8ajg. Otein Losing Enteropathy: Case Illustrations and. Ablo J. J Gastroenterol 2010; 105:4349; doi:10. Chronic inflammation may be a causative factor in a variety of cancers. Lganciclovir for Symptomatic Congenital Cytomegalovirus ...
Bedside Leukoreduction of Cellular Blood Components in Preventing Cytomegalovirus Transmission in Pediatric Allogeneic...Bedside Leukoreduction of Cellular Blood Components in Preventing Cytomegalovirus Transmission in Pediatric Allogeneic...
Background: Leukoreduction of cellular blood components is a standard practice in the Blood Bank to prevent cytomegalovirus transmission. This process is of utmost importance in our pediatric hematopoietic stem cell transplant (HSCT) patients who are immunocompromized and thus are susceptible to this infection. The objective of this study is to show that bedside leukoreduction of cellular blood products is a safe alternative to blood components from a very limited pool of CMV seronegative donors in pediatric HSCT recipients.. Methods: We conducted a retrospective analysis of our pediatric HSCT performed between 02/23/96 and 03/11/05. Screening for CMV antibody in our donors was discontinued in 02/23/96. Instead, we switched to bedside leukoreduction for patients who need CMV negative blood products, including the pediatric HSCT recipients. Transplant recipients and donors were tested for CMV antibody prior to transplant date. Patients and donors who were CMV seronegative pairs were included in ...
Serious Cytomegalovirus Disease in the Acquired Immunodeficiency Syndrome (AIDS)Clinical Findings, Diagnosis, and Treatment |...Serious Cytomegalovirus Disease in the Acquired Immunodeficiency Syndrome (AIDS)Clinical Findings, Diagnosis, and Treatment |...
Life-threatening opportunistic cytomegalovirus infection is a complication of the acquired immunodeficiency syndrome (AIDS) that occurs in 7.4% or more of patients with AIDS. Cytomegalovirus retinitis, colitis, esophagitis, and gastritis are the commonest manifestations of severe cytomegalovirus end-organ disease. Extensive trials with intravenous ganciclovir, a nucleoside analogue with myelosuppressive toxicity, have shown that ganciclovir halts the progression of cytomegalovirus retinitis and gastrointestinal disease. Since relapse is common when therapy is discontinued, most patients with AIDS need lifelong maintenance therapy. The clinical response to ganciclovir therapy is usually accompanied by diminished shedding of the virus. Based on limited data, foscarnet, a pyrophosphate analogue, also appears to have some efficacy in treating cytomegalovirus infection. Unlike ganciclovir, foscarnet does not cause myelosuppression. An important direction for future clinical research is the ...
Kinetics of US28 Gene Expression during Active Human Cytomegalovirus Infection in Lung-Transplant RecipientsKinetics of US28 Gene Expression during Active Human Cytomegalovirus Infection in Lung-Transplant Recipients
Targeting viral proteins early during infection may limit exacerbation of human cytomegalovirus infection. The viral chemokine-receptor homologue US28 interferes with leukocyte trafficking and, possibly, viral replication. Because US28 molecules are abundant on the surface of infected cells, this homologue is a potential target for antiviral therapy. To assess the relationship between US28 and disease activity, we measured, by quantitative reverse-transcription polymerase chain reaction, the levels of US28 and immediate-early (IE) 1 gene transcripts in the blood of lung-transplant recipients. We found that, during primary and secondary infection, the IE1 and US28 genes have early transcription kinetics and are expressed at similar levels. This may render US28 an attractive target for antiviral therapy ...
Cytomegalovirus infection of the adult nervous system.Cytomegalovirus infection of the adult nervous system.
Cytomegalovirus Infection of the Adult Nervous System Michael Duchowny, M D , Louis Caplan, M D , and George Siber, M D In 2 patients, 1 with brachial plexus neuropathy and another with relapsing chronic encephalitis, the acute neurological syndrome was accompanied by fever, tachycardia, abnormal liver function, and atypical lymphocytosis. Cytomegalovirus (CMV) infection was documented in both patients by viral isolation and a fourfold rise in complement-fixation titer. CMV may produce peripheral neuropathy, brachial plexus neuropathy, or a n acute or chronic meningoencephalitis in previously healthy adults without immune deficiency. Duchowny M, Caplan L, Siber G: Cytomegalovirus infection of the adult nervous system. Ann Neurol 5:458-461, 1979 T h e cytomegaloviruses (CMV) are members of the herpesvirus family characterized by their ability to produce striking cellular enlargement with intracellular inclusion bodies in epithelial cells [27]. Intrauterine infection with CMV has long been known ...
Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient -...Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient -...
Abstract: Congenital cytomegalovirus (CMV) infection occurs in approximately 1% of newborns and is the leading infectious cause of congenital birth defects. Female renal allograft recipients who develop CMV infection during pregnancy are at risk for both graft dysfunction and fetal morbidity. DNA-based analysis of amniotic fluid (AF) from at-risk pregnancies has been suggested as an adjunct/substitute for traditional culture. We have shown that CMV-polymerase chain reaction of AF is a useful diagnostic test for congenital CMV infection. Using this test we diagnosed CMV infection in the fetus of a 30-year-old renal transplant recipient. As termination was not an option for the family, the patient was extensively counseled and treated with oral ganciclovir. This resulted in clearance of the virus from the AF and the delivery of a healthy newborn girl, free of CMV disease. This is the first reported case to our knowledge of successful use of maternal ganciclovir to treat intrauterine CMV infection ...
The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. - Department of PaediatricsThe effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. - Department of Paediatrics
BACKGROUND: Immune function declines with age and has been associated with reduced vaccine responsiveness. Chronic infection with cytomegalovirus (CMV) has been proposed as a contributor to poorer responses in older adults. A pneumococcal vaccine has been recommended in the United Kingdom for those aged |65 years since 2003 to prevent pneumococcal disease. METHODS: We evaluated the effect of age and CMV status on pneumococcal vaccine responses in 348 individuals aged 50-70 years. RESULTS: We found participant age to be associated with serotype-specific and functional antibody titers after pneumococcal vaccination, with a mean 6.2% (95% confidence interval, 2.9%-9.5%) reduction in postvaccination functional antibody titers per year. CMV status was not associated with serotype-specific immunoglobulin G concentrations or functional antibody titers after pneumococcal vaccination. However, CMV seropositivity was associated with higher levels of prevaccination functional antibody for 4 of 7 pneumococcal
Human Cytomegalovirus pUL79 Is an Elongation Factor of RNA Polymerase II for Viral Gene Transcription | proLékaře.czHuman Cytomegalovirus pUL79 Is an Elongation Factor of RNA Polymerase II for Viral Gene Transcription | proLékaře.cz
1. CroughT, KhannaR (2009) Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 22: 76-98.. 2. DeaytonJR, Prof SabinCA, JohnsonMA, EmeryVC, WilsonP, et al. (2004) Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet 363: 2116-2121.. 3. BuonsensoD, SerrantiD, GargiulloL, CeccarelliM, RannoO, et al. (2012) Congenital cytomegalovirus infection: current strategies and future perspectives. Eur Rev Med Pharmacol Sci 16: 919-935.. 4. GrattanMT, Moreno-CabralCE, StarnesVA, OyerPE, StinsonEB, et al. (1989) Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis. Jama 261: 3561-3566.. 5. KuvinJT, KimmelstielCD (1999) Infectious causes of atherosclerosis. Am Heart J 137: 216-226.. 6. MelnickJL, AdamE, DebakeyME (1993) Cytomegalovirus and atherosclerosis. Eur Heart J 14 Suppl K: 30-38.. 7. MuhlesteinJB, HorneBD, CarlquistJF, MadsenTE, ...
Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: An evidence-based reassessment of safety and...Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: An evidence-based reassessment of safety and...
TY - JOUR. T1 - Valganciclovir for cytomegalovirus prevention in solid organ transplant patients. T2 - An evidence-based reassessment of safety and efficacy. AU - Kalil, Andre C.. AU - Freifeld, Alison G.. AU - Lyden, Elizabeth R.. AU - Stoner, Julie A.. PY - 2009/5/13. Y1 - 2009/5/13. N2 - Background: Several anti-viral drugs have demonstrated efficacy in preventing Cytomegalovirus (CMV) infections in solid organ transplant (SOT) patients. The recently approved valganciclovir is the most commonly used and most expensive drug for CMV prevention. The safety and efficacy data have been drawn from a single trial. We hypothesized that valganciclovir may not be as safe as nor more effective than other therapies for CMV prevention. Methods: All experimental and analytical studies that compared valganciclovir with other therapies for prevention of CMV infection after SOT were selected. Based on meta-analytic and multivariate regression methodologies we critically analyzed all available evidence. ...
Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent...Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent...
Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. Therefore, we studied the effects of CMV reactivation on the temporal course of host response biomarkers in patients with sepsis. In this matched cohort study, each sepsis patient developing CMV reactivation between day 3 and 17 (CMV+) was compared with one CMV seropositive patient without reactivation (CMVs+) and one CMV seronegative patient (CMVs−). CMV serostatus and plasma loads were determined by enzyme-linked immunoassays and real-time polymerase chain reaction, respectively. Systemic interleukin-6 (IL-6), IL-8, IL-18, interferon-gamma-induced protein-10 (IP-10), neutrophilic elastase, IL-1 receptor antagonist (RA), and IL-10 were measured at five time points by multiplex immunoassay. The effects of CMV reactivation on sequential concentrations of these biomarkers were assessed in multivariable
A randomised, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human...A randomised, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human...
Cytomegalovirus (CMV) disease is a common complication of advanced human immunodeficiency virus (HIV) infection. Administration of oral valaciclovir, a valine ester of acyclovir, achieves sufficient plasma acyclovir levels to inhibit many clinical isolates. Acyclovir has been associated with enhanced survival in AIDS but not with CMV disease prevention. CMV-seropositive patients (1227) with CD4 cell counts ,100/mm3 were enrolled in a randomized, double-blind trial. Valaciclovir, 8 g/day, was compared with acyclovir, 3.2 or 0.8 g/day, for CMV prevention; all three arms were compared for survival. The confirmed CMV disease rate was 11.7% among valaciclovir recipients and 17.5% in the pooled acyclovir arms, a 33% reduction in risk. Time to confirmed CMV disease was significantly longer for the valaciclovir group (P = .03). A trend toward earlier mortality for valaciclovir recipients was seen (P = .06). Toxicity and earlier medication discontinuation were more common in this group. Valaciclovir ...
Incidence and Clinical Features of Ganciclovir- Resistant Cytomegalovirus Disease in Heart Transplant Recipients : Clinical...Incidence and Clinical Features of Ganciclovir- Resistant Cytomegalovirus Disease in Heart Transplant Recipients : Clinical...
Background.The incidence and clinical and virologic aspects of ganciclovir-resistant cytomegalovirus (CMV) disease have not been well-characterized in heart transplant recipients.. Methods.We retrospectively analyzed all patients who underwent their first heart transplantation during the period from 1 January 1995 through 30 June 2005 at a single health care center. Cox proportional hazard regression was used to assess the relationship between clinical variables and CMV disease. Portions of the UL97 gene were sequenced in patients with slow clinical and/or virologic response to ganciclovir therapy.. Results.Cytomegalovirus disease developed in 32 (11.7%) of 274 patients at a median of 4.2 months after transplantation (range, 1.8-11.6 months after transplantation) and was independently associated with donor-seropositive/recipient-seronegative (D+/R-) serostatus (adjusted hazard ratio, 6.93; P , .001). The incidence of ganciclovir-resistant CMV disease was 1.5% overall (4 of 274 patients), 5% ...
Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta...Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta...
Cytomegalovirus (CMV) infection is common in immunocompetent patients in intensive care units (ICUs). However, whether CMV infection or CMV reactivation contributes to mortality of immunocompetent patients remains unclear. A literature search was conducted for relevant studies published before May 30, 2016. Studies reporting on CMV infection in immunocompetent patients in ICUs and containing 2 × 2 tables on CMV results and all-cause mortality were included. Eighteen studies involving 2398 immunocompetent patients admitted to ICUs were included in the meta-analysis. The overall rate of CMV infection was 27% (95%CI 22-34%, I2 = 89%, n = 2398) and the CMV reactivation was 31% (95%CI 24-39%, I2 = 74%, n = 666). The odds ratio (OR) for all-cause mortality among patients with CMV infection, compared with those without infection, was 2.16 (95%CI 1.70-2.74, I2 = 10%, n = 2239). Moreover, upon exclusion of studies in which antiviral treatment was possibly or definitely provided to some patients, the association
Cytomegalovirus-induced immunopathology and its clinical consequences | Herpesviridae | Full TextCytomegalovirus-induced immunopathology and its clinical consequences | Herpesviridae | Full Text
Human cytomegalovirus (CMV) is a ubiquitous DNA virus that causes severe disease in patients with immature or impaired immune systems. During active infection, CMV modulates host immunity, and CMV-infected patients often develop signs of immune dysfunction, such as immunosuppression and autoimmune phenomena. Furthermore, active viral infection has been observed in several autoimmune diseases, and case reports have linked primary CMV infection and the onset of autoimmune disorders. In addition, CMV infection promotes allograft rejection and graft-versus-host disease in solid organ and bone marrow transplant recipients, respectively, further implicating CMV in the genesis and maintenance of immunopathological phenomena. The mechanisms by which CMV could induce inhibition of host defense, inflammation, and autoimmunity are discussed, as is the treatment of virus-induced immunopathology with antivirals.
Rhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infection | Microbiology SocietyRhesus brain microvascular endothelial cells are permissive for rhesus cytomegalovirus infection | Microbiology Society
Endothelial cells (EC) are an important cell type for human cytomegalovirus (CMV) pathogenesis. To characterize better the role of EC in primate CMV natural history, rhesus macaque microvascular EC (MVEC) were purified from fetal brain and analysed for infectivity by rhesus cytomegalovirus (RhCMV). Rhesus brain MVEC (BrMVEC) in culture were positive for von Willebrand factor and CD105 expression, uptake of acetylated low-density lipoprotein, and formation of capillary-like tubules on Matrigel, all phenotypic hallmarks of EC. BrMVEC were fully permissive for infection by RhCMV strain 68-1, and detectable plaques formed within 5 days of infection. Infectivity of BrMVEC by RhCMV could be reduced, but not abolished, by treatment of cells either before or during infection with pro-inflammatory mediators tumour necrosis factor-α, interleukin-1β or phorbol 12-myristate 13-acetate. These results demonstrate that in vitro infection of rhesus BrMVEC is a dynamic process that is influenced by activation
Ganciclovir - WikipediaGanciclovir - Wikipedia
Ganciclovir is an antiviral medication used to treat cytomegalovirus (CMV) infections. A prodrug form with improved oral bioavailability (valganciclovir) has also been developed. Ganciclovir was approved for medical use in 1994. Ganciclovir is indicated for: Sight-threatening CMV retinitis in severely immunocompromised people CMV pneumonitis in bone marrow transplant recipients Prevention of CMV disease in bone marrow and solid organ transplant recipients Confirmed CMV retinitis in people with AIDS (intravitreal implant) It is also used for acute CMV colitis in HIV/AIDS and CMV pneumonitis in immunosuppressed patients. Ganciclovir has also been used with some success in treating Human herpesvirus 6 infections. Ganciclovir has also been found to be an effective treatment for herpes simplex virus epithelial keratitis. Ganciclovir is commonly associated with a range of serious haematological adverse effects. Common adverse drug reactions (≥1% of patients) include: granulocytopenia, neutropenia, ...
Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation | Evidence-Based Medicine GuidelinesCytomegalovirus prophylaxis with antiviral agents for solid organ transplantation | Evidence-Based Medicine Guidelines
Cytomegalovirus prophylaxis with antiviral agents for solid organ transplantation answers are found in the Evidence-Based Medicine Guidelines powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Developing a prophylactic vaccine for human cytomegalovirus - QIMR BerghoferDeveloping a prophylactic vaccine for human cytomegalovirus - QIMR Berghofer
Human cytomegalovirus (HCMV) is the most significant microbial cause of birth defects, including brain damage and deafness, in developed nations. There is a compelling argument that a reduction in HCMV load would provide significant benefit in improving human health and reducing health care costs. Vaccination is the most practical way to achieve such a reduction in HCMV load. There are two important clinical settings where vaccination will have a significant impact on health outcome. The first is the prevention of the sequelae of congenital HCMV infection. A prophylactic vaccine to prevent congenital HCMV infection would make a major public health and economic contribution by reducing the incidence of birth defects.. The second setting is the prevention of HCMV-related complications in organ transplantation. HCMV is a major pathogen in both solid organ and bone marrow transplant recipients. We have identified a large number of cytotoxic T cell epitopes from a variety of HCMV antigens. A subset ...
Cytomegalovirus Immune Globulin Prophylaxis in Liver TransplantationA Randomized, Double-blind, Placebo-controlled Trial |...Cytomegalovirus Immune Globulin Prophylaxis in Liver TransplantationA Randomized, Double-blind, Placebo-controlled Trial |...
Results:. Using a Cox proportional-hazards model, CMVIG was shown to reduce severe CMV-associated disease (multi-organ CMV disease, CMV pneumonia, or invasive fungal disease associated with CMV infection) from 26% to 12% (relative risk, 0.39; 95% CI, 0.17 to 0.89). When we controlled for the use of monoclonal antibodies to T cells (OKT3), CMVIG use was still protective (relative risk, 0.39; CI, 0.17 to 0.90). Rates of CMV disease were reduced from 31% to 19% (relative risk, 0.56; CI, 0.3 to 1.1) in CMVIG recipients although no effect on rates of CMV infection, graft survival, or patient survival at 1 year were shown. When we controlled for the urgency of transplantation and OKT3 use, a reduction in CMV disease (relative risk, 0.22; CI, 0.06 to 0.81) was shown for globulin recipients for all serologic groups except for the highest risk group (the CMV-seropositive donor, CMV-seronegative group). ...
Human Cytomegalovirus Infection Promotes Rapid Maturation of NK Cells Expressing Activating Killer Ig-like Receptor in Patients...Human Cytomegalovirus Infection Promotes Rapid Maturation of NK Cells Expressing Activating Killer Ig-like Receptor in Patients...
Previous studies revealed that HCMV infection induces a persistent reconfiguration of the NK cell compartment characterized by the expansion of an NK cell subset expressing the activating NKG2C receptor. This finding has been demonstrated both in healthy individuals and in patients with different pathological conditions (10-16, 30, 31). Remarkably, in patients undergoing UCBT, HCMV infection/reactivation markedly influenced NK cell reconstitution, promoting the rapid appearance and expansion of NKG2C+KIR+NKG2A−Siglec-7− NK cells (17, 18). These studies suggested that the NKG2C activating receptor could play a crucial role in NK cell expansion and/or maturation driven by HCMV infection.. In the present study, we analyzed the maturation and function of NK cells developing in three patients transplanted with cord blood cells from donors carrying homozygous deletion of the NKG2C gene and undergoing HCMV infection. These cases offered a unique opportunity to analyze the features of NK cell ...
Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature.
Cytomegalovirus-associated thrombosis has been extensively reported in the medical literature, mainly in immune-compromised patients. However, the association with splenic infarcts has been rarely mentioned. We report the case of a 38-year-old
Cmv Colitis Related Keywords & Suggestions - Cmv Colitis Long Tail KeywordsCmv Colitis Related Keywords & Suggestions - Cmv Colitis Long Tail Keywords
These are some of the images that we found within the public domain for your "Cmv Colitis" keyword. These images will give you an idea of the kind of image(s) to place in your articles and wesbites. You can always use one of these images but please respect the copyright of the owner, We have provided the original source link for you to also credit the image(s) owner as we have done here.. ...
Cytomegaloviral colitis in HIV positive patients: endoscopic findingsCytomegaloviral colitis in HIV positive patients: endoscopic findings
MARQUES JR, Oswaldo et al. Cytomegaloviral colitis in HIV positive patients: endoscopic findings. Arq. Gastroenterol. [online]. 2007, vol.44, n.4, pp.315-319. ISSN 0004-2803. http://dx.doi.org/10.1590/S0004-28032007000400007.. BACKGROUND: Diarrhea in seropositive human immunodeficiency virus patients is one of the most important and disabling symptoms, and often decreases their quality of life. Cytomegalovirus colitis is among the principal causes of this symptom and colonoscopy is the gold standard examination to diagnose it. AIM: To define the main endoscopic findings in seropositive human immunodeficiency virus patients with cytomegalovirus colitis. METHODS: Two hundred and forty-three colonoscopies were performed in 200 seropositive human immunodeficiency virus patients with diarrhea associated or not to abdominal pain or gastrointestinal bleeding, over 10-year period, whom 51 patients were diagnosed with cytomegalovirus colitis. Full length colonoscopy with ileum intubation was always tried ...
Evidence for a Role of the Cellular ND10 Protein PML in Mediating Intrinsic Immunity against Human Cytomegalovirus Infections |...Evidence for a Role of the Cellular ND10 Protein PML in Mediating Intrinsic Immunity against Human Cytomegalovirus Infections |...
This study was initiated in order to define the relevance of ND10 domains for HCMV replication. Experimental results of previous studies suggested that ND10 domains may play a pivotal role for the initiation of HCMV IE gene expression. Arguments that could be interpreted in favor of such a proviral role of ND10 were as follows: (i) viral genomes were found to be deposited at the periphery of ND10 (29, 31); (ii) several regulatory proteins of HCMV at least transiently colocalize with PML and other ND10 components (2, 26, 32, 37); (iii) an immediate transcript environment consisting of viral IE transcripts, the IE2 protein, and SC35 domains was reported to form adjacent to ND10-localized HCMV genomes, suggesting that this spatial association is critical for the correct initiation of viral gene expression (31); (iv) only ND10-associated viral genomes were shown to develop into viral replication compartments (4, 48).. As an experimental approach to study the role of ND10 for HCMV replication, we ...
P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells....P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells....
Human cytomegalovirus (HCMV) manipulates many aspects of host cell biology to create an intracellular milieu optimally supportive of its replication and spread. Our study reveals that levels of several components of the purinergic signaling system, including the P2Y2 and P2X5 receptors, are elevated in HCMV-infected fibroblasts. Knockdown and drug treatment experiments demonstrated that P2Y2 enhances the yield of virus, whereas P2X5 reduces HCMV production. The HCMV IE1 protein induces P2Y2 expression; and P2Y2-mediated signaling is important for efficient HCMV gene expression, DNA synthesis, and the production of infectious HCMV progeny. P2Y2 cooperates with the viral UL37x1 protein to regulate cystolic Ca2+ levels. P2Y2 also regulates PI3K/Akt signaling and infected cell motility. Thus, P2Y2 functions at multiple points within the viral replication cycle to support the efficient production of HCMV progeny, and it may facilitate in vivo viral spread through its role in cell migration. ...
Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. | Journal of...Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. | Journal of...
Antiviral mechanisms by which natural killer (NK) cells control murine cytomegalovirus (MCMV) infection in the spleens and livers of C57BL/6 mice were measured, revealing different mechanisms of control in different organs. Three days postinfection, MCMV titers in the spleens of perforin 0/0 mice were higher than in those of perforin +/+ mice, but no elevation of liver titers was found in perforin 0/0 mice. NK cell depletion in MCMV-infected perforin 0/0 mice resulted only in an increase in liver viral titers and not in spleen titers. Depletion of gamma interferon (IFN-gamma) in C57BL/6 mice by injections with monoclonal antibodies to IFN-gamma resulted in an increase of viral titers in the liver but not in the spleen. Analyses using IFN-gamma-receptor-deficient mice, rendered chimeric with C57BL/6 bone marrow cells, indicated that in a recipient environment where IFN-gamma cannot exert its effects, the depletion of NK cells caused an increase in MCMV titers in the spleens but had little effect ...
cytomegalovirus p150 recombinant cytomegalovirus p150 Gentaur Molecular Productscytomegalovirus p150 recombinant cytomegalovirus p150 Gentaur Molecular Products
cytomegalovirus p150 recombinant cytomegalovirus p150 | order cytomegalovirus p150 recombinant cytomegalovirus p150 | How to use: cytomegalovirus p150 recombinant cyto
Table 1 | Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production...Table 1 | Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production...
Table 1: Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation
Evaluation of an electronic, patient-focused management system aimed at preventing cytomegalovirus disease following solid...Evaluation of an electronic, patient-focused management system aimed at preventing cytomegalovirus disease following solid...
BACKGROUND: Cytomegalovirus (CMV) infection is common among solid organ transplant (SOT) recipients and may cause CMV disease. To optimize the implementation of existing prevention strategies, the Management of Post-transplant Infections in Collaborating Hospitals (MATCH) program was developed. Two key performances of MATCH (diagnosing CMV infection at low viral load (VL) and before the onset of CMV disease) were assessed prior to, during and after the implementation of MATCH.. METHODS: The MATCH program included a personalized surveillance plan, prophylaxis and preemptive therapy determined by the recipients risk of CMV infection. The plan was composed through predefined algorithms and implemented through harvesting of real-time data from medical records. Risk of CMV disease was compared for recipients transplanted during and after vs prior to the implementation of MATCH. Lung and non-lung transplants were analyzed separately.. RESULTS: A total of 593, 349, 520, and 360 SOT recipients were ...
Maribavir Markedly Reduced Cytomegalovirus Infection | EmaxHealthMaribavir Markedly Reduced Cytomegalovirus Infection | EmaxHealth
In a 111 subject study, maribavir significantly reduced the rate of CMV infection requiring treatment across all dose ranges (15 percent, p=0.001; 30 percent, p=0.051 and 15 percent, p=0.002 in 100 mg BID, 400 mg QD, 400 mg BID doses respectively), compared to placebo (57 percent). No patients taking maribavir at any dose developed CMV disease, compared to the placebo group in which three subjects (11 percent) developed the disease. Moreover, there were no reports of late CMV disease across any treatment groups with a maximum follow up period of five months post-transplant.. "These results are important because they suggest that maribavir has the potential to shift the CMV management strategy in stem cell transplant from pre-emptive therapy to prophylaxis," said Drew J. Winston, M.D., University of California, Los Angeles Medical Center. "It is clear that maribavir has the potential to offer an important new and safer option for clinicians to prevent CMV disease in transplant patients.". Among ...
Eligibility NCT00372229 Cytomegalovirus Infections - Portal of Medical Data Models (MDM-Portal)Eligibility NCT00372229 Cytomegalovirus Infections - Portal of Medical Data Models (MDM-Portal)
ODM derived from http://clinicaltrials.gov/show/NCT00372229; Keywords: Cytomegalovirus Infections, Clinical Trial, Kidney Transplantation, Eligibility Determination
Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological StudiesDetection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies
Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on
Int J Fertil SterilInt J Fertil Steril
Some evidence has shown a relationship between primary human cytomegalovirus (CMV) infection and pregnancy loss. The impact of CMV infection reactivation during pregnancy on adverse pregnancy outcomes is not completely understood. It is proposed that altered immune response, and therefore, recurrence or reactivation of latent CMV infection may relate to recurrent spontaneous abortion (RSA); however, few data are available in this regard. To find out about any cell mediated defect and reactivation of latent CMV infection in women with RPL, cellular immunity to the virus has been evaluated by specific cytotoxic T lymphocyte (CTL) response to CMV. ...
Valganciclovir Hcl - Valganciclovir Hcl Manufacturers and Valganciclovir Hcl SuppliersValganciclovir Hcl - Valganciclovir Hcl Manufacturers and Valganciclovir Hcl Suppliers
ALL Manufacturer of Valganciclovir Hcl for Valganciclovir Hcl, China valganciclovir hcl information resources . valganciclovir hcl Marketplace In Taiwan ,China and Asian Manufacturers,Help you to find more Manufacturers,Suppliers,Exporter,Agent,Global valganciclovir hcl buyers, valganciclovir hcl,valganciclovir hcl Factory.
Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV...Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV...
Rationale: There is mounting evidence of a higher incidence of coronary heart disease in cytomegalovirus-seropositive individuals.Objective: The aim of this study was to investigate whether acute myocardial infarction triggers an inflammatory T-cell response that might lead to accelerated immunosenescence in cytomegalovirus-seropositive patients.Methods and Results: Thirty-four patients with acute myocardial infarction undergoing primary percutaneous coronary intervention were longitudinally studied within 3 months after reperfusion (Cohort A). In addition, 54 patients with acute myocardial infarction and chronic myocardial infarction were analyzed in a cross-sectional study (Cohort B). Cytomegalovirus-seropositive patients demonstrated a greater fall in the concentration of terminally differentiated CD8 effector memory T cells (T-EMRA) in peripheral blood during the first 30 minutes of reperfusion compared with cytomegalovirus-seronegative patients (-192 versus -63 cells/mu L; P=0.008), ...
A study on variability of human cytomegalovirus UL144 gene in low-passage clinical isolates--《Chinese Journal of Microbiology...A study on variability of human cytomegalovirus UL144 gene in low-passage clinical isolates--《Chinese Journal of Microbiology...
Objective Human cytomegalovirus (HCMV) is an important infectious factor that results in neonatal disease and congenital deformity. HCMV may invade many organs. The different symptoms and tissue tropism of HCMV infection perhaps result from the genetic polymorphism of HCMV. Recent study showed that Toledo genome contained 19 open reading frames (denoted UL131 to 151) which were not present in the AD169 genome, leading us to focus on the relationship between HCMV disease and the products of these 19 open reading frames. UL144 open reading frames encode a homologue of the tumor necrosis factor receptor. It seems important to study the strain-specific variability of UL144 sequence in low-passage clinical isolates and to discuss if the variability related to the clinical HCMV infection. Methods HCMV-UL144 gene was amplified by PCR assay in 65 low-passage clinical isolates and urine from 7 healthy children, which were HCMV-DNA positive as shown by QPCR. All the positive PCR products were analyzed by HMA
Repositorio da Producao Cientifica e Intelectual da Unicamp: Diagnostico e genotipagem de citomegalovirus humano (HCMV) em...Repositorio da Producao Cientifica e Intelectual da Unicamp: Diagnostico e genotipagem de citomegalovirus humano (HCMV) em...
Abstract: Human cytomegalovirus (HCMV) remains the most important cause of serious viral infections in pediatric transplant recipients. In these patients, early diagnosis of active HCMV infection is important since the development of HCMV disease may be prevented. Ganciclovir has been established as an effective treatment agent for active infection by HCMV. HCMV disease can occur from infection acquired by the transplanted organ or from re-activation of latent infection. The risk is highest within 2 months of transplantation. Several risk factors for disease have been identified and include: HCMV-positive donor, HCMV-negative recipient, lack of anti-viral prophylaxis, and receipt of cadaveric kidney or type of bone marrow transplant. Intense immunosuppression has also been implicated. For discriminate patients with active infection from those without such infection, tests that include the pp65 antigenemia assay (AGM) and DNA detection methods are describle. The polymarase chain reaction (PCR) is ...
Epigenetics of human herpesvirus latencyEpigenetics of human herpesvirus latency
List of infectious diseasesList of infectious diseases
HIV/AIDS in the United KingdomHIV/AIDS in the United Kingdom
LissencephalyLissencephaly
Hearing lossHearing loss
Intraventricular hemorrhageIntraventricular hemorrhage
TORCH syndromeTORCH syndrome
Eruptive pseudoangiomatosisEruptive pseudoangiomatosis
HLA-A11HLA-A11
RegavirumabRegavirumab
MicrolissencephalyMicrolissencephaly
Blueberry muffin babyBlueberry muffin baby
George Siber bibliographyGeorge Siber bibliography
Audiology and hearing health professionals in developed and developing countriesAudiology and hearing health professionals in developed and developing countries
Bruce BeutlerBruce Beutler
GanciclovirGanciclovir
Blood transfusionBlood transfusion
Alanine aminopeptidaseAlanine aminopeptidase
Transverse myelitisTransverse myelitis
Geum japonicumGeum japonicum
Retrospective diagnosisRetrospective diagnosis
Lipschütz ulcerLipschütz ulcer
RubellaRubella
Infant formulaInfant formula
Catherine PeckhamCatherine Peckham
HerpesviridaeHerpesviridae
Natural killer cellNatural killer cell
LetermovirLetermovir
T细胞 - 维基百科，自由的百科全书T细胞 - 维基百科，自由的百科全书
Neonatal conjunctivitisNeonatal conjunctivitis
ImmunosenescenceImmunosenescence
রাতকানা - উইকিপিডিয়ারাতকানা - উইকিপিডিয়া
JC virusJC virus
Artificial induction of immunityArtificial induction of immunity
Index of HIV/AIDS-related articlesIndex of HIV/AIDS-related articles
Hepatit - VikipediHepatit - Vikipedi
Corneal dystrophyCorneal dystrophy
Epidemiology of herpes simplexEpidemiology of herpes simplex
Kayser-Fleischer ringKayser-Fleischer ring
ConjunctivitisConjunctivitis
Respiratory syncytial virus vaccineRespiratory syncytial virus vaccine
PericardiumPericardium
Immunologic adjuvantImmunologic adjuvant
Rotavirus vaccineRotavirus vaccine
එන්නත් - විකිපීඩියාඑන්නත් - විකිපීඩියා
Hantavirus vaccineHantavirus vaccine
Biettis crystalline dystrophyBietti's crystalline dystrophy
Primary central nervous system lymphomaPrimary central nervous system lymphoma
JaundiceJaundice
List of neurological conditions and disordersList of neurological conditions and disorders
TLR2TLR2
කොවිඩ්-19 - විකිපීඩියාකොවිඩ්-19 - විකිපීඩියා
Color blindnessColor blindness
Birth defectBirth defect
Aphthous stomatitisAphthous stomatitis
Necrotizing vasculitisNecrotizing vasculitis
List of vaccine topicsList of vaccine topics
Aphthous stomatitisAphthous stomatitis
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Cytomegalovirus InfectionsCytomegalovirusMuromegalovirusGanciclovirCytomegalovirus RetinitisCytomegalovirus VaccinesHerpesviridae InfectionsAntiviral AgentsAntibodies, ViralFoscarnetDNA, ViralImmediate-Early ProteinsImmunocompetenceAntigens, ViralPregnancy Complications, InfectiousVirus ReplicationViral ProteinsKidney TransplantationVirus ActivationRoseolovirusViral Matrix ProteinsFibroblastsImmunocompromised HostGastritis, HypertrophicImmunoglobulin MPolymerase Chain ReactionOpportunistic InfectionsInfant, NewbornTransplantation, HomologousGenes, Immediate-EarlySalivary GlandsViremiaFetal DiseasesUrineInfectious Disease Transmission, VerticalComplement Fixation TestsCells, CulturedOrgan TransplantationGene Expression Regulation, ViralImmunoglobulin GPneumonia, ViralAIDS-Related Opportunistic InfectionsPregnancyRibonucleosidesMice, Inbred BALB CHerpesvirus 6, HumanCell LineKiller Cells, NaturalViral Plaque AssayBone Marrow TransplantationAcyclovirViral LoadViral Envelope ProteinsImmunosuppressionTime FactorsInfant, Newborn, DiseasesGraft RejectionCytopathogenic Effect, ViralSpleenGenes, ViralCytosineOrganophosphonatesPostoperative ComplicationsInclusion Bodies, ViralNK Cell Lectin-Like Receptor Subfamily AImmunity, CellularMolecular Sequence DataPhosphoproteinsLiver TransplantationVirus LatencyTransplantationImmunosuppressive AgentsCD8-Positive T-LymphocytesNeonatal ScreeningLung TransplantationVirologyHypoproteinemiaHearing Loss, SensorineuralBase SequenceSerologic TestsLymphotoxin alpha1, beta2 HeterotrimerHeart TransplantationOrganophosphorus CompoundsAcquired Immunodeficiency SyndromeRoseolovirus InfectionsTissue DonorsChild CareHearing Loss, CentralEnzyme-Linked Immunosorbent AssayMice, Inbred C57BLLymphocyte ActivationProspective StudiesAcute DiseaseFluorescent Antibody TechniqueHematopoietic Stem Cell TransplantationTransplantsVirus CultivationRetrospective StudiesHerpesviridaeT-LymphocytesPlacenta DiseasesChorionic VilliSplenomegalyHost-Pathogen InteractionsSensitivity and SpecificityAmniotic FluidTransplantation ImmunologyGraft SurvivalRisk FactorsHepatitisHistocompatibility Antigens Class ILungInterferon-gammaPsychomotor DisordersLeukocytesAntilymphocyte SerumInfectious MononucleosisMicrocephalyTreatment OutcomeBetaherpesvirinaeHerpes SimplexAmino Acid SequenceSpecific Pathogen-Free OrganismsNK Cell Lectin-Like Receptor Subfamily CBALB 3T3 CellsImmunoglobulins, IntravenousRecurrenceSeroepidemiologic StudiesGastrointestinal DiseasesIncidenceGraft vs Host DiseaseLiverRNA, ViralCD4-Positive T-LymphocytesMilk, HumanAlabamaPancreas TransplantationPolyradiculoneuropathyRetinitisMembrane GlycoproteinsNIH 3T3 Cells
Cytomegalovirus Infections Clinical Research Trials | CenterWatchCytomegalovirus Infections Clinical Research Trials | CenterWatch
New Medical Therapies Trial Results in Cytomegalovirus Infections | CenterWatchNew Medical Therapies Trial Results in Cytomegalovirus Infections | CenterWatch
Cytomegalovirus infection as a cause of ileoanal pouchitis | SpringerLinkCytomegalovirus infection as a cause of ileoanal pouchitis | SpringerLink
Prevention of active cytomegalovirus infection and disease in kidney transplant recipientsPrevention of active cytomegalovirus infection and disease in kidney transplant recipients
Neutropenia and congenital cytomegalovirus infectionNeutropenia and congenital cytomegalovirus infection
Human Cytomegalovirus Infection: Biological Features, Transmission, Symptoms, Diagnosis, and Treatment | IntechOpenHuman Cytomegalovirus Infection: Biological Features, Transmission, Symptoms, Diagnosis, and Treatment | IntechOpen
Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus...Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus...
Cytomegalovirus in female patients attending a VD clinic. | Sexually Transmitted InfectionsCytomegalovirus in female patients attending a VD clinic. | Sexually Transmitted Infections
Neurodevelopmental assessment after congenital cytomegalovirus infection. | Archives of Disease in ChildhoodNeurodevelopmental assessment after congenital cytomegalovirus infection. | Archives of Disease in Childhood
Congenital Cytomegalovirus Infection: Time to Test Newborns? - ENTtodayCongenital Cytomegalovirus Infection: Time to Test Newborns? - ENTtoday
Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell TransplantationValacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation
Healthcare costs attributable to congenital cytomegalovirus infection | Archives of Disease in ChildhoodHealthcare costs attributable to congenital cytomegalovirus infection | Archives of Disease in Childhood
Role of the Laboratory in Diagnosis and Management of Cytomegalovirus Infection in Hematopoietic Stem Cell and Solid-Organ...Role of the Laboratory in Diagnosis and Management of Cytomegalovirus Infection in Hematopoietic Stem Cell and Solid-Organ...
About Cytomegalovirus and Congenital CMV Infection | CDCAbout Cytomegalovirus and Congenital CMV Infection | CDC
Cytomegalovirus Infections: MedlinePlusCytomegalovirus Infections: MedlinePlus
Cytomegalovirus (CMV) and Congenital CMV Infection | CDCCytomegalovirus (CMV) and Congenital CMV Infection | CDC
Cytomegalovirus (CMV) infection: MedlinePlus Medical EncyclopediaCytomegalovirus (CMV) infection: MedlinePlus Medical Encyclopedia
Congenital cytomegalovirus infectionsCongenital cytomegalovirus infections
Vaccine prevention of maternal cytomegalovirus infection. - PubMed - NCBIVaccine prevention of maternal cytomegalovirus infection. - PubMed - NCBI
Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection. | The BMJLymphocytotoxic antibodies in spontaneous cytomegalovirus infection. | The BMJ
Pediatric Cytomegalovirus Infection: Background, Pathophysiology, EpidemiologyPediatric Cytomegalovirus Infection: Background, Pathophysiology, Epidemiology
Congenital Cytomegalovirus Infection | SpringerLinkCongenital Cytomegalovirus Infection | SpringerLink
Congenital cytomegalovirus infection - WikipediaCongenital cytomegalovirus infection - Wikipedia
Cytomegalovirus InfectionCytomegalovirus Infection
Strongyloides Hyperinfection Syndrome Combined with Cytomegalovirus InfectionStrongyloides Hyperinfection Syndrome Combined with Cytomegalovirus Infection
Antiviral Treatment of Cytomegalovirus Infection: Ingenta ConnectAntiviral Treatment of Cytomegalovirus Infection: Ingenta Connect
Cytomegalovirus | Pediatric Opportunistic Infection | AIDSinfoCytomegalovirus | Pediatric Opportunistic Infection | AIDSinfo
Cytomegalovirus (CMV) infection - Diagnosis and treatment - Mayo ClinicCytomegalovirus (CMV) infection - Diagnosis and treatment - Mayo Clinic
Maribavir Markedly Reduced Cytomegalovirus Infection | EmaxHealthMaribavir Markedly Reduced Cytomegalovirus Infection | EmaxHealth
Latent infection and the elusive cytomegalovirusLatent infection and the elusive cytomegalovirus
Brief | Cytomegalovirus | Pediatric Opportunistic Infection | AIDSinfoBrief | Cytomegalovirus | Pediatric Opportunistic Infection | AIDSinfo
KEGG DISEASE: Cytomegalovirus infectionKEGG DISEASE: Cytomegalovirus infection
Enhancing treatment of Cytomegalovirus (CMV) infection | University of SurreyEnhancing treatment of Cytomegalovirus (CMV) infection | University of Surrey
Infection by cytomegalovirus in p... preview & related info | MendeleyInfection by cytomegalovirus in p... preview & related info | Mendeley
Cytomegalovirus Infection May Contribute to Metabolic SyndromeCytomegalovirus Infection May Contribute to Metabolic Syndrome
Cytomegalovirus Infections | GreenMedInfo | Disease | NaturalCytomegalovirus Infections | GreenMedInfo | Disease | Natural
Manifestations of Cytomegalovirus Infection | IntechOpenManifestations of Cytomegalovirus Infection | IntechOpen
B-cell activation following murine cytomegalovirus infection: implications for autoimmunity. - PubMed - NCBIB-cell activation following murine cytomegalovirus infection: implications for autoimmunity. - PubMed - NCBI
Which clinical history findings are characteristic of cytomegalovirus retinitis in HIV infection?Which clinical history findings are characteristic of cytomegalovirus retinitis in HIV infection?
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Cytomegalovirus InfectionsCytomegalovirusMuromegalovirusGanciclovirCytomegalovirus RetinitisCytomegalovirus VaccinesHerpesviridae InfectionsAntiviral AgentsAntibodies, ViralFoscarnetDNA, ViralImmediate-Early ProteinsImmunocompetenceAntigens, ViralPregnancy Complications, InfectiousVirus ReplicationViral ProteinsKidney TransplantationVirus ActivationRoseolovirusViral Matrix ProteinsFibroblastsImmunocompromised HostGastritis, HypertrophicImmunoglobulin MPolymerase Chain ReactionOpportunistic InfectionsInfant, NewbornTransplantation, HomologousGenes, Immediate-EarlySalivary GlandsViremiaFetal DiseasesUrineInfectious Disease Transmission, VerticalComplement Fixation TestsCells, CulturedOrgan TransplantationGene Expression Regulation, ViralImmunoglobulin GPneumonia, ViralAIDS-Related Opportunistic InfectionsPregnancyRibonucleosidesMice, Inbred BALB CHerpesvirus 6, HumanCell LineKiller Cells, NaturalViral Plaque AssayBone Marrow TransplantationAcyclovirViral LoadViral Envelope ProteinsImmunosuppressionTime FactorsInfant, Newborn, DiseasesGraft RejectionCytopathogenic Effect, ViralSpleenGenes, ViralCytosineOrganophosphonatesPostoperative ComplicationsInclusion Bodies, ViralNK Cell Lectin-Like Receptor Subfamily AImmunity, CellularMolecular Sequence DataPhosphoproteinsLiver TransplantationVirus LatencyTransplantationImmunosuppressive AgentsCD8-Positive T-LymphocytesNeonatal ScreeningLung TransplantationVirologyHypoproteinemiaHearing Loss, SensorineuralBase SequenceSerologic TestsLymphotoxin alpha1, beta2 HeterotrimerHeart TransplantationOrganophosphorus CompoundsAcquired Immunodeficiency SyndromeRoseolovirus InfectionsTissue DonorsChild CareHearing Loss, CentralEnzyme-Linked Immunosorbent AssayMice, Inbred C57BLLymphocyte ActivationProspective StudiesAcute DiseaseFluorescent Antibody TechniqueHematopoietic Stem Cell TransplantationTransplantsVirus CultivationRetrospective StudiesHerpesviridaeT-LymphocytesPlacenta DiseasesChorionic VilliSplenomegalyHost-Pathogen InteractionsSensitivity and SpecificityAmniotic FluidTransplantation ImmunologyGraft SurvivalRisk FactorsHepatitisHistocompatibility Antigens Class ILungInterferon-gammaPsychomotor DisordersLeukocytesAntilymphocyte SerumInfectious MononucleosisMicrocephalyTreatment OutcomeBetaherpesvirinaeHerpes SimplexAmino Acid SequenceSpecific Pathogen-Free OrganismsNK Cell Lectin-Like Receptor Subfamily CBALB 3T3 CellsImmunoglobulins, IntravenousRecurrenceSeroepidemiologic StudiesGastrointestinal DiseasesIncidenceGraft vs Host DiseaseLiverRNA, ViralCD4-Positive T-LymphocytesMilk, HumanAlabamaPancreas TransplantationPolyradiculoneuropathyRetinitisMembrane GlycoproteinsNIH 3T3 Cells
DiagnosisHCMVAsymptomaticReactivationTransplantationClinicalAcuteLatentRecipientsDiseaseTransplantIncidenceAntibodiesPatientsSymptomsOpportunistic infectionsHerpes simplSymptomaticCongenital CMVTreatmentHumansHumanViremiaViral infectionsColitisComplicationsImmune systemDiseasesMurine
Diagnosis4
HCMV4
  • Recently, it has been shown that humanCMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical cord blood transplantation by accelerating the differentiation of mature NKG2A - killer Ig-like receptor (KIR) + NK cells characterized by the expression of the NKG2C-activating receptor. (elsevier.com)
  • In view of the hypothesis that NKG2C could be directly involved in NK cell maturation driven by HCMV infection, we analyzed the maturation and function of NK cells developing in three patients with hematological malignancies given umbilical cord blood transplantation from donors carrying a homozygous deletion of the NKG2C gene. (elsevier.com)
  • We show that HCMV infection can drive rapid NK maturation, characterized by the expansion of CD56 dim NKG2A - KIR + cells, even in the absence of NKG2C expression. (elsevier.com)
  • Given the absence of NKG2C, it is conceivable that activating KIRs may play a role in the HCMV-driven NK cell maturation and that NK cells expressing activating KIRs might contribute, at least in part, to the control of infections after transplantation. (elsevier.com)
Asymptomatic3
Reactivation2
Transplantation2
Clinical11
Acute2
Latent3
Recipients8
Disease5
Transplant1
Incidence3
Antibodies1
Patients5
Symptoms4
Opportunistic infections1
  • Additionally, CMV influences allograft dysfunction, accelerates graft coronary artery atherosclerosis, and increases opportunistic infections ( 33 ). (asm.org)
Herpes simpl1
  • Human cytomegalovirus (CMV), an infectious agent that is ubiquitous in the world population, is a member of human herpesvirus family including viruses such as Epstein-Barr virus, herpes simplex virus, and varicella zoster. (intechopen.com)
Symptomatic2
Congenital CMV2
Treatment1
Humans3
Human2
Viremia1
Viral infections2
  • However, the presence of striking cerebellar hypoplasia, reminiscent of some viral infections of the central nervous system described in the experimental animal models, has prompted this short communication. (uab.edu)
  • In infants, HIV infection occurs at a time when many infants also acquire persistent viral infections (herpes viruses: EBV/CMV/HHV-8). (google.com)
Colitis1
Complications1
Immune system1
Diseases1
Murine4
PLOS ONE: Impact of Persistent Cytomegalovirus Infection on Dynamic Changes in Human Immune System Profile
PLOS ONE: Impact of Persistent Cytomegalovirus Infection on Dynamic Changes in Human Immune System Profile (journals.plos.org)
Cytomegalovirus (CMV) infection - Diagnosis and treatment - Mayo Clinic
Cytomegalovirus (CMV) infection - Diagnosis and treatment - Mayo Clinic (mayoclinic.org)
Antiviral Treatment of Cytomegalovirus Infection: Ingenta Connect
Antiviral Treatment of Cytomegalovirus Infection: Ingenta Connect (ingentaconnect.com)
Cytomegalovirus (CMV): Practice Essentials, Background, Pathophysiology
Cytomegalovirus (CMV): Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
Congenital Cytomegalovirus Infection | SpringerLink
Congenital Cytomegalovirus Infection | SpringerLink (link.springer.com)
Cytomegalovirus Infections | GreenMedInfo | Disease | Natural
Cytomegalovirus Infections | GreenMedInfo | Disease | Natural (greenmedinfo.com)
May 2004 - Volume 12 - Issue 3 : Infectious Diseases in Clinical Practice
May 2004 - Volume 12 - Issue 3 : Infectious Diseases in Clinical Practice (journals.lww.com)
Latent Cytomegalovirus Infection and Blood Transfusion | Annals of Internal Medicine | American College of Physicians
Latent Cytomegalovirus Infection and Blood Transfusion | Annals of Internal Medicine | American College of Physicians (annals.org)
Cytomegalovirus Infection May Contribute to Metabolic Syndrome
Cytomegalovirus Infection May Contribute to Metabolic Syndrome (lifeboat.com)
In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir - Full Text View - ClinicalTrials.gov
In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Frontiers | Potential beneficial effects of cytomegalovirus-infection after transplantation | Immunology
Frontiers | Potential beneficial effects of cytomegalovirus-infection after transplantation | Immunology (frontiersin.org)
Global Cell Therapy Market To Surpass US$ 35 Billion By 2026 | Medgadget
Global Cell Therapy Market To Surpass US$ 35 Billion By 2026 | Medgadget (medgadget.com)
Knowledge and Practices of Obstetricians and Gynecologists Regarding Cytomegalovirus Infection During Pregnancy --- United...
Knowledge and Practices of Obstetricians and Gynecologists Regarding Cytomegalovirus Infection During Pregnancy --- United... (cdc.gov)
Cytomegalovirus Infections | Profiles RNS
Cytomegalovirus Infections | Profiles RNS (profiles.umassmed.edu)
Cytomegalovirus infection - Symptoms, diagnosis and treatment | BMJ Best Practice
Cytomegalovirus infection - Symptoms, diagnosis and treatment | BMJ Best Practice (bestpractice.bmj.com)
Health Topics: C: MedlinePlus
Health Topics: C: MedlinePlus (medlineplus.gov)
Febrile/cold agglutinins: MedlinePlus Medical Encyclopedia
Febrile/cold agglutinins: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Cytomegalovirus Infections: MedlinePlus
Cytomegalovirus Infections: MedlinePlus (medlineplus.gov)
JCM | Free Full-Text | Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in...
JCM | Free Full-Text | Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in... (mdpi.com)
Pediatric Annals | November 2002 Issue
Pediatric Annals | November 2002 Issue (healio.com)
How to Cure Colitis (with Pictures) - wikiHow
How to Cure Colitis (with Pictures) - wikiHow (wikihow.com)