Cytomegalovirus. Medical search

A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.

A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. Murid herpesvirus is the type species.

Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.

An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.

Deoxyribonucleic acid that makes up the genetic material of viruses.

Proteins found in any species of virus.

Virus diseases caused by the HERPESVIRIDAE.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

Substances elaborated by viruses that have antigenic activity.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.

Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.

Established cell cultures that have the potential to propagate indefinitely.

The functional hereditary units of VIRUSES.

A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, whose viruses have been isolated from lymphocytes. HERPESVIRUS 6, HUMAN is the type species.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.

Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The presence of viruses in the blood.

Transference of an organ between individuals of the same species or between individuals of different species.

The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.

Inflammation of the lung parenchyma that is caused by a viral infection.

A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.

Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.

Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).

The transference of a kidney from one human or animal to another.

A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.

Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.

The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.

The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.

Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).

The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.

An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.

Elements of limited time intervals, contributing to particular results or situations.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Process of growing viruses in live animals, plants, or cultured cells.

A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.

Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.

A pyrimidine base that is a fundamental unit of nucleic acids.

Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Glycoproteins found on the membrane or surface of cells.

Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.

DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Ribonucleic acid that makes up the genetic material of viruses.

A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

The transference of either one or both of the lungs from one human or animal to another.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.

An infant during the first month after birth.

A general term for diseases produced by viruses.

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.

An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.

A species in the genus ROSEOLOVIRUS, of the family HERPESVIRIDAE. It was isolated from activated, CD4-positive T-lymphocytes taken from the blood of a healthy human.

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.

The interactions between a host and a pathogen, usually resulting in disease.

Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.

The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.

Antibodies produced by a single clone of cells.

A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)

The transference of a part of or an entire liver from one human or animal to another.

An inhibitory subclass of NK cell lectin-like receptors that interacts with CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS and prevents the activation of NK CELLS.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Diagnostic procedures involving immunoglobulin reactions.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

The process by which a DNA molecule is duplicated.

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (1/5460)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum. (+info)

Cytomegalovirus seropositivity and incident ischaemic heart disease in the Caerphilly prospective heart disease study. (2/5460)

OBJECTIVE: To assess the role of cytomegalovirus (CMV) infection in primary ischaemic heart disease. METHODS: Plasma specimens collected during 1979-83 from men in Caerphilly, south Wales, were analysed for IgG antibodies to CMV by enzyme linked immunosorbent assay and latex tests. Incident ischaemic heart disease events were ascertained after five and 10 years from death certificates, hospital records, and ECG changes; 195 incident ischaemic heart disease cases were compared with 216 controls of a similar age drawn from the rest of the cohort. RESULTS: 164 cases (84%) and 180 controls (83%) were seropositive for CMV. Optical density, an indicator of CMV antibody titre, was similar for cases and controls. Among controls, seropositivity was not associated with age, socioeconomic status currently or in childhood, smoking, height, body mass index, blood pressure, total cholesterol, fibrinogen, plasma viscosity, or leucocyte count. The unadjusted odds ratio relating CMV seropositivity to incident ischaemic heart disease was 1.06 (95% confidence interval 0.63 to 1.79) and was little changed (1.11, 0.63 to 1.97) after adjustment for age, smoking, body mass index, systolic blood pressure, total cholesterol, and socioeconomic status currently and in childhood. CONCLUSIONS: CMV infection is unlikely to be a strong risk factor for development of myocardial infarction in middle aged men. (+info)

Detection of Chlamydia pneumoniae but not cytomegalovirus in occluded saphenous vein coronary artery bypass grafts. (3/5460)

BACKGROUND: A causal relation between atherosclerosis and chronic infection with Chlamydia pneumoniae and/or cytomegalovirus (CMV) has been suggested. Whether the unresolved problem of venous coronary artery bypass graft occlusion is related to infection with C pneumoniae and/or CMV has not been addressed. METHODS AND RESUTLS: Thirty-eight occluded coronary artery vein grafts and 20 native saphenous veins were examined. Detection of C pneumoniae DNA was performed by use of nested polymerase chain reaction (PCR). Homogenisates from the specimen were cultured for identification of viable C pneumoniae. Both conventional PCR and quantitative PCR for detection of CMV DNA were applied. Differential pathological changes (degree of inflammation, smooth muscle cell proliferation [MIB-1]) were determined and correlated to the detection of both microorganisms. C pneumoniae DNA could be detected in 25% of occluded vein grafts. Viable C pneumoniae was recovered from 16% of occluded vein grafts. Except for 1 native saphenous vein, all control vessels were negative for both C pneumoniae detection and culture. All pathological and control specimens were negative for CMV DNA detection. Pathological changes did not correlate with C pneumoniae detection. CONCLUSIONS: Occluded aorto-coronary venous grafts harbor C pneumoniae but not CMV. The detection of C pneumoniae in occluded vein grafts warrants further investigation. (+info)

Evaluation of fibroblast-mediated gene therapy in a feline model of mucopolysaccharidosis type VI. (4/5460)

Fibroblast-mediated ex vivo gene therapy was evaluated in the N-acetylgalactosamine 4-sulfatase (4S) deficient mucopolysaccharidosis type VI (MPS VI) cat. Skin biopsies were obtained at birth from severely affected MPS VI kittens and used to initiate fibroblast outgrowths for retroviral transduction with the 4S cDNA. 4S gene expression in transduced cells was under the transcriptional control of the MoMLV long terminal repeat promoter or the cytomegalovirus (CMV) immediate-early promoter. Characterisation of gene-transduced fibroblasts demonstrated the cells to be over-expressing 4S activity. Twenty-four to forty million autologous, gene-corrected fibroblasts were implanted under the renal capsule of three MPS VI kittens at 8-16 weeks of age. Transient, low levels of 4S activity were detected in peripheral blood leukocytes shortly after implantation but were not detectable within 3-8 weeks' post-implantation. Long-term biochemical and clinical evaluation of these cats demonstrated identical disease progression to that previously described in untreated, clinically severe MPS VI cats. (+info)

The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation. (5/5460)

At our institution, the cytomegalovirus (CMV) prophylaxis protocol for allogeneic bone marrow transplant (BMT) recipients who are CMV-seropositive or receive marrow from a CMV-seropositive donor consists of a surveillance bronchoscopy approximately 35 days posttransplant. Patients with a positive surveillance bronchoscopy for CMV receive pre-emptive ganciclovir. In order to determine the utility of other screening methods for CMV, we prospectively performed weekly CMV antigenemia, and blood, urine and throat cultures from time of engraftment to day 120 post-BMT in 126 consecutive patients. Pre-emptive ganciclovir was given to 11/81 patients (13.6%) because of a positive surveillance bronchoscopy for CMV. Results of CMV blood, urine and throat cultures and the antigenemia assay done prior to or at the time of the surveillance bronchoscopy were analyzed for their ability to predict the bronchoscopy result. The antigenemia test had the highest positive and negative predictive values (72% and 96%, respectively). The ability of these tests to predict CMV disease was evaluated in the 70 patients with a negative surveillance bronchoscopy who did not receive pre-emptive ganciclovir. Of 19 cases of active CMV disease, CMV antigenemia was positive in 15 patients (79%) a mean of 34 days preceding symptoms. Blood cultures were positive in 14/19 patients (74%) a mean of 31 days before onset of disease. CMV antigenemia is useful for predicting the surveillance bronchoscopy result, and also predicts the development of CMV disease in the majority of patients missed by the surveillance bronchoscopy. (+info)

Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. (6/5460)

Cidofovir is the first nucleoside monophosphate analogue currently being used for the treatment of human cytomegalovirus (HCMV) retinitis in individuals with AIDS. Unfortunately, the period of therapy with the use of this compound may be limited due to the possible emergence of serious irreversible nephrotoxic effects. New drugs with improved toxicity profiles are needed. The goal of this study was to investigate the anticytomegaloviral properties and drug-induced toxicity of a novel phosphonate analogue, namely, (-)-2-(R)-dihydroxyphosphinoyl-5-(S)-(guanin-9'-yl-methyl) tetrahydrofuran (compound 1), in comparison with those of cidofovir. The inhibitory activities of both compounds on HCMV propagation in vitro were similar against the AD 169 and Towne strains, with 50% inhibitory concentrations ranging from 0.02 to 0.17 microgram/ml for cidofovir and < 0.05 to 0.09 microgram/ml for compound 1. A clinical HCMV isolate that was resistant to ganciclovir and that had a known mutation within the UL54 DNA polymerase gene and a cidofovir-resistant laboratory strain derived from strain AD 169 remained sensitive to compound 1, whereas their susceptibilities to ganciclovir and cidofovir were reduced by 33- and 10-fold, respectively. Both compound 1 and cidofovir exhibited equal potencies in an experimentally induced murine cytomegalovirus (MCMV) infection in mice, with a prevention or prolongation of mean day to death at dosages of 1.0, 3.2, and 10.0 mg/kg of body weight/day. In cytotoxicity experiments, compound 1 was found to be generally more toxic than cidofovir in cell lines Hs68, HFF, and 3T3-L1 (which are permissive for HCMV or MCMV replication) but less toxic than cidofovir in MRC-5 cells (which are permissive for HCMV replication). Drug-induced toxic side effects were noticed for both compounds in rats and guinea pigs in a 5-day repeated-dose study. In guinea pigs, a greater weight loss was noticed with cidofovir than with compound 1 at dosages of 3.0 and 10.0 mg/kg/day. An opposite effect was detected in rats, which were treated with the compounds at relatively high dosages (up to 100 mg/kg/day). Compound 1 and cidofovir were nephrotoxic in both rats and guinea pigs, with the epithelium lining the proximal convoluted tubules in the renal cortex being the primary target site. The incidence and the severity of the lesions were found to be dose dependent. The lesions observed were characterized by cytoplasm degeneration and nuclear modifications such as karyomegaly, the presence of pseudoinclusions, apoptosis, and degenerative changes. In the guinea pig model, a greater incidence and severity of lesions were observed for cidofovir than for compound 1 (P < 0.001) with a drug regimen of 10 mg/kg/day. (+info)

Reversing adipocyte differentiation: implications for treatment of obesity. (7/5460)

Conventional treatment of obesity reduces fat in mature adipocytes but leaves them with lipogenic enzymes capable of rapid resynthesis of fat, a likely factor in treatment failure. Adenovirus-induced hyperleptinemia in normal rats results in rapid nonketotic fat loss that persists after hyperleptinemia disappears, whereas pair-fed controls regain their weight in 2 weeks. We report here that the hyperleptinemia depletes adipocyte fat while profoundly down-regulating lipogenic enzymes and their transcription factor, peroxisome proliferator-activated receptor (PPAR)gamma in epididymal fat; enzymes of fatty acid oxidation and their transcription factor, PPARalpha, normally low in adipocytes, are up-regulated, as are uncoupling proteins 1 and 2. This transformation of adipocytes from cells that store triglycerides to fatty acid-oxidizing cells is accompanied by loss of the adipocyte markers, adipocyte fatty acid-binding protein 2, tumor necrosis factor alpha, and leptin, and by the appearance of the preadipocyte marker Pref-1. These findings suggest a strategy for the treatment of obesity by alteration of the adipocyte phenotype. (+info)

Human herpesviruses in chronic fatigue syndrome. (8/5460)

We have conducted a double-blind study to assess the possible involvement of the human herpesviruses (HHVs) HHV6, HHV7, Epstein-Barr virus (EBV), and cytomegalovirus in chronic fatigue syndrome (CFS) patients compared to age-, race-, and gender-matched controls. The CFS patient population was composed of rigorously screened civilian and Persian Gulf War veterans meeting the Centers for Disease Control and Prevention's CFS case definition criteria. Healthy control civilian and veteran populations had no evidence of CFS or any other exclusionary medical or psychiatric condition. Patient peripheral blood mononuclear cells were analyzed by PCR for the presence of these HHVs. Using two-tailed Fisher's exact test analyses, we were unable to ascertain any statistically significant differences between the CFS patient and control populations in terms of the detection of one or more of these viruses. This observation was upheld when the CFS populations were further stratified with regard to the presence or absence of major axis I psychopathology and patient self-reported gradual versus acute onset of disease. In tandem, we performed serological analyses of serum anti-EBV and anti-HHV6 antibody titers and found no significant differences between the CFS and control patients. (+info)

1990). "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169". Cytomegaloviruses. ... Wikimedia Commons has media related to Cytomegalovirus. Wikispecies has information related to Cytomegalovirus. ICTV (Articles ... and Simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus (RhCMV) that infect macaques; CCMV is known as both Panine beta ... "cytomegalovirus". In 1990, the first draft of human cytomegalovirus genome was published, the biggest contiguous genome ...

https://en.wikipedia.org/wiki/Cytomegalovirus

Blurred vision Blind spots Specks in your vision Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus ... Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness ... The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal ... Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those ...

https://en.wikipedia.org/wiki/Cytomegalovirus_retinitis

... is a form of esophagitis associated with cytomegalovirus. Symptoms include dysphagia, upper ... "About Cytomegalovirus and Congenital CMV Infection , CDC". www.cdc.gov. 2019-11-04. Retrieved 2019-11-19. Zaidi, Syed Ali; ... Pain can also manifest as heartburn symptoms Nausea/vomiting Fever There are multiple ways cytomegalovirus can be transmitted. ... Parente, F.; Porro, Bianchi (March 1998). "Treatment of Cytomegalovirus Esophagitis in Patients With Acquired Immune Deficiency ...

https://en.wikipedia.org/wiki/Cytomegalovirus_esophagitis

... , also known as CMV colitis, is an inflammation of the colon. The infection is spread by saliva, urine, ... Lawlor G, Moss AC (September 2010). "Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander?". Inflamm. ... Crohn's disease Kandiel A, Lashner B (December 2006). "Cytomegalovirus colitis complicating inflammatory bowel disease". Am. J ...

https://en.wikipedia.org/wiki/Cytomegalovirus_colitis

A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or curb virus re-activation (symptomatic ... In 2016, VBI Vaccines commenced a Phase I preventative cytomegalovirus vaccine study (VBI-1501). Other cytomegalovirus vaccines ... As a member of the TORCH complex, cytomegalovirus can cause congenital infection, which can lead to neurological problems, ... Arvin AM, Fast P, Myers M, Plotkin S, Rabinovich R (July 2004). "Vaccine development to prevent cytomegalovirus disease: report ...

https://en.wikipedia.org/wiki/Cytomegalovirus_vaccine

Congenital cytomegalovirus (CMV) infection refers to a condition where cytomegalovirus is transmitted in the prenatal period. ... Human cytomegalovirus is one of the vertically transmitted infections that lead to congenital abnormalities. Others include ... Congenital cytomegalovirus infection can be an important cause of intraventricular hemorrhage and neonatal encephalopathy. ... One study did not show significant decrease in the risk of congenital cytomegalovirus infection. Most healthy people working ...

https://en.wikipedia.org/wiki/Congenital_cytomegalovirus_infection

... , also called human cytomegalovirus (HCMV), is species of virus in the genus Cytomegalovirus, which in ... containing a standardized number of antibodies to cytomegalovirus. It may be used for the prophylaxis of cytomegalovirus ... In disseminated cytomegalovirus infections, as may be seen in the context of an immunosuppressed host, the virus is readily ... Further cytomegalovirus vaccines candidates are the CMV-MVA Triplex vaccine and the CMVpp65-A*0201 peptide vaccine. Both ...

https://en.wikipedia.org/wiki/Human_betaherpesvirus_5

Schleiss, M. R. (2008). "Cytomegalovirus vaccine development". Human Cytomegalovirus. Current Topics in Microbiology and ... Adenovirus vaccine COVID-19 vaccine (Part of today's pandemic since 2019) Coxsackie B virus vaccine Cytomegalovirus vaccine ...

https://en.wikipedia.org/wiki/List_of_vaccine_topics

Schleiss, M. R. (2008). "Cytomegalovirus vaccine development". Human Cytomegalovirus. Current Topics in Microbiology and ...

https://en.wikipedia.org/wiki/List_of_infectious_diseases

Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Human Cytomegalovirus. Curr. Top. ... Sissons JG, Bain M, Wills MR (February 2002). "Latency and reactivation of human cytomegalovirus". J. Infect. 44 (2): 73-77. ... Sinclair J (March 2008). "Human cytomegalovirus: Latency and reactivation in the myeloid lineage". J. Clin. Virol. 41 (3): 180- ...

https://en.wikipedia.org/wiki/Introduction_to_viruses

Cytomegalovirus (CMV) is a member of the betaherpesvirinae subfamily. CMV is responsible for a range of diseases, but mainly ... "Cytomegalovirus Infections: MedlinePlus". www.nlm.nih.gov. Retrieved 2015-05-13. Kaslow, Richard A.; Stanberry, Lawrence R.; ... Liu, X.; Wang, X.; Yan, S.; Zhang, Z.; Abecassis, M.; Hummel, M. (2013). "Epigenetic Control of Cytomegalovirus Latency and ...

https://en.wikipedia.org/wiki/Epigenetics_of_human_herpesvirus_latency

"Cytomegalovirus (CMV) colitis". www.pathologyoutlines.com. Retrieved 2019-04-11. "Herpes Group (Cytomegalovirus, Herpes simplex ... and Cytomegalovirus. They are named after Edmund Cowdry. There are two types of intranuclear Cowdry bodies: Type A (as seen in ...

https://en.wikipedia.org/wiki/Cowdry_bodies

Cytomegalovirus (CMV) is a herpes related virus that can cause congenital defects. CMV has a high affinity for the developing ... Joseph LD, Kuruvilla S (2008). "Cytomegalovirus infection with lissencephaly". Indian Journal of Pathology & Microbiology. 51 ( ... Joseph LD, Pushpalatha, Kuruvilla S (2008). "Cytomegalovirus infection with lissencephaly". Indian Journal of Pathology & ...

https://en.wikipedia.org/wiki/Lissencephaly

"MXB inhibits murine cytomegalovirus". Virology. 522: 158-167. doi:10.1016/j.virol.2018.07.017. PMID 30032029. Staeheli P, ...

https://en.wikipedia.org/wiki/MX2

Sezgen E, An P, Winkler CA (23 July 2019). "Host Genetics of Cytomegalovirus Pathogenesis". Front Genet. 10: 616. doi:10.3389/ ...

https://en.wikipedia.org/wiki/Duplodnaviria

Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. ... Fowler KB (December 2013). "Congenital cytomegalovirus infection: audiologic outcome". Clinical Infectious Diseases. 57 Suppl 4 ...

https://en.wikipedia.org/wiki/Hearing_loss

Its mechanism of action has been found to be similar in use against human cytomegalovirus. Lobucavir's bioavailability is 30-40 ... It reached phase III clinical trials for hepatitis B and herpesvirus, phase II clinical trials for cytomegalovirus, and ... Lobucavir has been shown to exhibit antiviral activity against herpesvirus, hepatitis B, HIV/AIDS, and human cytomegalovirus. ... Hoffman VF, Skiest DJ (February 2000). "Therapeutic developments in cytomegalovirus retinitis". Expert Opinion on ...

https://en.wikipedia.org/wiki/Lobucavir

Valcyte (valganciclovir), for cytomegalovirus infection. Valium (diazepam), for anxiety disorders, alcohol withdrawal, status ... Cymevene (ganciclovir), for cytomegalovirus infection. Dalmane/Dalmadorm (flurazepam), for insomnia. Dilatrend (carvedilol), ...

https://en.wikipedia.org/wiki/Roche

... and cytomegalovirus. Boston exanthem disease Skin lesion James, William D.; Berger, Timothy G.; et al. (2006). Andrews' ... "Eruptive pseudoangiomatosis associated to cytomegalovirus infection". Eur J Dermatol. 17 (5): 455-6. doi:10.1684/ejd.2007.0257 ...

https://en.wikipedia.org/wiki/Eruptive_pseudoangiomatosis

The recipient, however, died from cytomegalovirus. Following the introduction of cyclosporine, his unit went on to perform ...

https://en.wikipedia.org/wiki/Christian_Cabrol

"Cytomegalovirus Adult and Adolescent Opportunistic Infection". AIDSinfo. Retrieved 2020-04-25. "Vascular Endothelial Growth ... Since the 1990s, intravitreal antivirals have been used to treat cytomegalovirus retinitis (CMV retinitis) in immunodeficient ...

https://en.wikipedia.org/wiki/Intravitreal_injection

Iannetti P, Morellini M, Raucci U, Cappellacci S (1988). "HLA antigens, epilepsy and cytomegalovirus infection". Brain Dev. 10 ... Associations have been observed between A11 and familial otosclerosis, pulmonary tuberculosis, leprosy, and cytomegalovirus ...

https://en.wikipedia.org/wiki/HLA-A11

Certain viruses, such as human cytomegalovirus (HCMV) and hepatitis C (HCV), have adapted to suppress the function of MAVS in ... Ashley CL, Abendroth A, McSharry BP, Slobedman B (2019). "Interferon-Independent Innate Responses to Cytomegalovirus". ...

https://en.wikipedia.org/wiki/Mitochondrial_antiviral-signaling_protein

Visser, LH; Van Der Meché, FG; Meulstee, J; Rothbarth, PP; Jacobs, BC; Schmitz, PI; Van Doorn, PA (1996). "Cytomegalovirus ... Powiązania przyczynowo-skutkowe?" [Cytomegalovirus infection in acute myocardial infarction. Is there a causative relationship ... Rider, JR; Ollier, WE; Lock, RJ; Brookes, ST; Pamphilon, DH (1997). "Human cytomegalovirus infection and systemic lupus ... Phillips, Anna C.; Carroll, Douglas; Khan, Naeem; Moss, Paul (2008). "Cytomegalovirus is associated with depression and anxiety ...

https://en.wikipedia.org/wiki/Infections_associated_with_diseases

Sissons JG, Bain M, Wills MR (February 2002). "Latency and reactivation of human cytomegalovirus". The Journal of Infection. 44 ... Isomura H, Stinski MF (February 2013). "Coordination of late gene transcription of human cytomegalovirus with viral DNA ... Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Current Topics in Microbiology and ... Sinclair J (March 2008). "Human cytomegalovirus: Latency and reactivation in the myeloid lineage". Journal of Clinical Virology ...

https://en.wikipedia.org/wiki/Virus

Nguyen M, Bradford K, Zhang X, Shih DQ (January 2011). "Cytomegalovirus Reactivation in Ulcerative Colitis Patients". Ulcers. ... difficile infection and cytomegalovirus infection (due to reactivation). Together with Crohn's disease, about 11.2 million ... Cytomegalovirus-associated diseases, Diarrhea, Inflammations, Noninfective enteritis and colitis, Steroid-responsive ...

https://en.wikipedia.org/wiki/Ulcerative_colitis

Polymorphonuclear leukocyte function during cytomegalovirus mononucleosis. Clin Immunol Immunopath. 1979; 12:331-334. 44. ...

https://en.wikipedia.org/wiki/Thomas_P._Stossel

... cytomegalovirus, and Epstein-Barr virus. There are many more virus members that infect animals other than humans, some of which ... and human cytomegalovirus, which causes congenital herpes. The results indicated that CRISPR can be used to eliminate ... is researching to utilize cytomegalovirus vectors in the development of a therapeutic vaccine against herpes simplex virus 2 ( ... an antiviral medication used to treat and prevent cytomegaloviruses, converts it into the nucleoside analogue triphosphates. ...

https://en.wikipedia.org/wiki/Herpes_simplex_research

Specific CD8+ T cells are generated in secondary lymphoid organs where naïve T cells encounter with cytomegalovirus antigen on ... The amount of memory cells generated as a response to cytomegalovirus is approximately 9.1% - 10.2% of all circulating CD4 + ... Kim, Jihye; Kim, A-Reum; Shin, Eui-Cheol (August 2015). "Cytomegalovirus Infection and Memory T Cell Inflation". Immune Network ... Shin, Eui-Cheol; Kim, A.-Reum; Kim, Jihye (2015-08-01). "Cytomegalovirus Infection and Memory T Cell Inflation". Immune Network ...

https://en.wikipedia.org/wiki/Memory_T_cell_inflation

"Consensus on the role of human cytomegalovirus in glioblastoma". Neuro-Oncology. 14 (3): 246-55. doi:10.1093/neuonc/nor227. PMC ... Barami K (July 2010). "Oncomodulatory mechanisms of human cytomegalovirus in gliomas". Journal of Clinical Neuroscience. 17 (7 ... "Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ ... "Oncomodulation by human cytomegalovirus: novel clinical findings open new roads". Medical Microbiology and Immunology. 200 (1 ...

https://en.wikipedia.org/wiki/Glioma

Cytomegalovirus (CMV) is a very common herpesviridae virus. Most people will be infected at some point during their lifetime. ... Congenital cytomegalovirus infection (cCMV) occurs when the CMV crosses the placenta during pregnancy and infects the fetus. ... Photograph source: Işikay S, Yilmaz K. Congenital cytomegalovirus infection and finger anomaly. Case Reports. 2013;2013: ...

https://www.cdc.gov/ncbddd/birthdefects/surveillancemanual/quick-reference-handbook/congenital-cytomegalovirus.html

Cytomegalovirus (CMV) is a virus found worldwide. Most people with CMV dont need treatment. Learn about who is at risk and how ... Article: Another tool against cytomegalovirus after allogeneic hematopoietic cell transplantation. * Cytomegalovirus Infections ... Acute cytomegalovirus (CMV) infection (Medical Encyclopedia) Also in Spanish * CMV - gastroenteritis/colitis (Medical ... Cytomegalovirus (CMV) and Pregnancy (Organization of Teratology Information Specialists) - PDF Also in Spanish ...

https://medlineplus.gov/cytomegalovirusinfections.html

Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2, Epstein-Barr virus, ... Clinical utility of cytomegalovirus antigenemia assay and blood cytomegalovirus DNA PCR for cytomegaloviral colitis patients ... encoded search term (Cytomegalovirus Colitis) and Cytomegalovirus Colitis What to Read Next on Medscape ... Cytomegalovirus Colitis. Updated: May 17, 2021 * Author: Douglas M Heuman, MD, FACP, FACG, AGAF; Chief Editor: BS Anand, MD ...

https://www.medscape.com/answers/173151-174931/what-is-the-global-prevalence-of-cytomegalovirus-cmv-colitis

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://apps.who.int/iris/browse?authority=Cytomegalovirus+Retinitis&type=mesh

Cytomegalovirus is a common herpes virus. Many people do not know they have it because they may have no symptoms. ... Cytomegalovirus is a common herpes virus that affects 50% of people by the age of 40 years.. ... Acquired cytomegalovirus can spread between people through bodily fluids, such as saliva, semen, blood, urine, vaginal fluids, ... Also known as HCMV, CMV, or human herpesvirus 5 (HHV-5), cytomegalovirus is the most commonly transmitted virus to a developing ...

https://www.medicalnewstoday.com/articles/173811?utm_source=ReadNext

Cytomegalovirus (CMV) is a common virus that often affects kids in early childhood. Review symptoms and treatment options. ... What is Cytomegalovirus (CMV)?. Cytomegalovirus (CMV) is a common virus that infects most people during their life. Most people ... Treatment for Cytomegalovirus An antiviral medication may be used to treat a cytomegalovirus infection in people whose immune ... Cytomegalovirus is only spread through contact with an infected persons body fluids, such as saliva, blood, urine, or breast ...

https://www.cincinnatichildrens.org/health/c/cytomegalovirus

Cytomegalovirus Genotypes - Urine (Surplus) (SSCMVG_A) Data File: SSCMVG_A.xpt First Published: June 2017. Last Revised: NA ... Rapid Genotyping of Cytomegalovirus in Dried Blood Spots by Multiplex Real-Time PCR Assays Targeting the Envelope Glycoprotein ... Among participants aged 6-49 years in NHANES between 1999 and 2004 who were cytomegalovirus (CMV) IgG positive, had stored ...

https://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/SSCMVG_A.htm

CMV or cytomegalovirus, is a common virus that is spread via body fluids. It can cause complications in an unborn baby if ... CMV or cytomegalovirus is a common virus that is spread through body fluids such as saliva, tears, blood, urine, breast milk, ... Cytomegalovirus can be diagnosed using a simple blood test that looks for antibodies against the virus or by measuring actual ... Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol. 2010;20(4): ...

https://www.verywellhealth.com/what-is-cmv-cytomegalovirus-1191881

Collaborative study to evaluate the proposed 1st [‎first]‎ WHO international standard for human cytomegalovirus (‎HCMV)‎ for ... of the WHO collaborative study to establish the first international standard for detection of IgG antibodies to cytomegalovirus ...

https://extranet.who.int/iris/restricted/browse?locale-attribute=en&type=mesh&authority=Cytomegalovirus

The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated. ... Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- ... Arterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8+ T Cells J Am Heart Assoc. 2017 Aug 28;6(9): ... Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell ...

https://pubmed.ncbi.nlm.nih.gov/28847915/?dopt=Abstract

CMV, cytomegalovirus.. Subsequent testing demonstrated a serum albumin fraction of 1.46 g/dL, free kappa light chain 2.08 mg/dL ... Cytomegalovirus (CMV) colitis, on the other hand, is generally diagnosed in immunosuppressed patients and is rare in ... Concurrent Cytomegalovirus Colitis and Gastrointestinal Amyloidosis as Initial Presentation of Multiple Myeloma. Atuluru, ... Concurrent Cytomegalovirus Colitis and Gastrointestinal Amyloidosis as Initial Presentation of Multiple Myeloma : ACG Case ...

https://journals.lww.com/acgcr/Fulltext/2022/10000/Concurrent_Cytomegalovirus_Colitis_and.22.aspx

Author summary Cytomegalovirus (CMV) remains a cause of disease in individuals with weakened immune systems such as patients ...

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006299

van Duin D, Miranda C, Husni E. Cytomegalovirus Viremia, Pneumonitis, and Tocilizumab Therapy. Emerging Infectious Diseases. ... van Duin D, Miranda C, Husni E. Cytomegalovirus Viremia, Pneumonitis, and Tocilizumab Therapy. Emerg Infect Dis. 2011;17(4):754 ... van Duin, D., Miranda, C., & Husni, E. (2011). Cytomegalovirus Viremia, Pneumonitis, and Tocilizumab Therapy. Emerging ... Cytomegalovirus Viremia, Pneumonitis, and Tocilizumab Therapy. Volume 17, Number 4-April 2011 ...

https://wwwnc.cdc.gov/eid/article/17/4/10-1057_article

Congenital cytomegalovirus infection is associated with congenital rickets: a retrospective autopsy cohort study ... Congenital cytomegalovirus infection is associated with congenital rickets: a retrospective autopsy cohort study ...

https://fn.bmj.com/content/early/2022/12/26/archdischild-2022-324760.responses

Treatment for cytomegalovirus (CMV) in pregnancy and babies. Long-term problems of congenital CMV. Your baby may be born with ... If you are healthy and you get cytomegalovirus (CMV), you may not have any symptoms. ...

https://www2.hse.ie/conditions/cytomegalovirus-pregnancy/symptoms/

Metabolic programming in murine cytomegalovirus infected macrophages Author: Kotzamanis, Konstantinos Ioannis ISNI: 0000 0004 ... investigate the integrative process by studying the metabolic programming of macrophages infected with murine cytomegalovirus ( ...

https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756522

Cytomegalovirus-R. Cytomegalovirus-SAS. Cytomegalovirus-Stata. Cytomegalovirus-SPSS. Cytomegalovirus-Minitab. Cytomegalovirus- ... Cytomegalovirus. 64. 26. Cytomegalovirus-Introduction. Cytomegalovirus Data Dictionary. Data Downloads. Posting Date. ... Cytomegalovirus (CMV) is a common virus that can infect almost anyone. Once infected, your body retains the virus for life. ... The cytomegalovirus dataset was contributed by Dr. Amy Nowacki, Associate Professor, Cleveland Clinic. Please refer to this ...

https://www.causeweb.org/tshs/cytomegalovirus/

Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants (ValEAR). The safety and ... Cytomegalovirus (CMV) can be transmitted from the mother to the fetus and is a leading cause of sensorineural hearing loss ( ... Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants: ValEAR Trial. ... of this study is to determine the clinical benefit and safety of antiviral therapy for asymptomatic congenital cytomegalovirus ...

https://www.clinicaltrials.gov/ct2/show/study/NCT03107871

Decreased production of cytokines after cytomegalovirus infection of marrow-derived stromal cells. Download Prime PubMed App to ... ConditionedCytokinesCytomegalovirusCytomegalovirus InfectionsGranulocyte Colony-Stimulating FactorGranulocyte-Macrophage Colony ... Cytomegalovirus (CMV) infection is frequently associated with graft failure in bone marrow transplant patients; the ... Decreased Production of Cytokines After Cytomegalovirus Infection of Marrow-derived Stromal Cells. Exp Hematol. 1994;22(1):26- ...

https://www.unboundmedicine.com/medline/citation/7506672/Decreased_production_of_cytokines_after_cytomegalovirus_infection_of_marrow_derived_stromal_cells_

The US FDA approved Takedas Livtencity to treat people aged 12 years and above with post-transplant cytomegalovirus infection/ ... Cytomegalovirus is a kind of herpes virus that causes infection in patients following a stem cell or organ transplant. Credit: ... FDA approves Takedas Livtencity for post-transplant cytomegalovirus. Livtencity, which works by hindering human ... to treat individuals aged 12 years and above with post-transplant cytomegalovirus (CMV) infection/disease. ...

https://www.pharmaceutical-technology.com/news/fda-approves-takeda-livtencity/

The E.Coli derived recombinant protein contains the CMV Pp150 (UL32) immunodominant regions. It belongs to the Betaherpesvirinae subfamily of Herpesviridae.

https://www.prospecbio.com/cmv_pp150

CONCLUSIONS: In this cohort study, postnatal cytomegalovirus infection in preterm children did not have an adverse effect on ... OBJECTIVES: To assess whether preterm infants with postnatal cytomegalovirus infection develop neurologic sequelae in early ... METHODS: Infants ,32 weeks gestation were prospectively screened for cytomegalovirus (CMV) at term-equivalent age. ...

https://dspace.library.uu.nl/handle/1874/362637

Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002). The ... Versus Valganciclovir for the Prevention of Human Cytomegalovirus (CMV) Disease in Adult Kidney Transplant Recipients. ...

https://clinicaltrials.gov/ct2/show/NCT03443869?cond=CMV&cntry=DE&city=Berlin&draw=2&rank=5

... and immune competent subjects who require therapy Purpose Cytomegalovirus (CMV) is a potential complication after stem cell ... Cytomegalovirus (CMV) is a potential complication after stem cell transplantation. There are drugs used to treat CMV, but in ... A Phase II Study of CMV-Immune T cells from a Third Party for the Treatment of Cytomegalovirus Infection after Allogeneic Stem ...

https://www.mskcc.org/cancer-care/clinical-trials/14-070

A Pilot Study in the Treatment of Refractory Cytomegalovirus (CMV) Infections With Related Donor CMV Specific Cytotoxic T-cells ... Clinical trial for Cytomegalovirus Infections , Primary Immune Deficiency Disorder , ... A Pilot Study in the Treatment of Refractory Cytomegalovirus (CMV) Infections With Related Donor CMV Specific Cytotoxic T-cells ... with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with ...

https://www.centerwatch.com/clinical-trials/listings/217425/virus-specific-cytotoxic-t-lymphocytes-ctls-for-refractory-cytomegalovirus-cmv/?page=3&query=cytomegalovirus-infections&rnk=27

Chronic infection especially by cytomegalovirus (CMV) has a dramatic influence on the T-cell compartment, both on CD8+ and CD4 ... Cytomegalovirus Harmfully Alters Immune Cell Populations in the Aging Immune System. Permalink Read 4 Comments Add a Comment ... For most people, cytomegalovirus (CMV) is an apparently innocuous persistent herpesvirus infection, one that presents no ...

https://www.fightaging.org/archives/2021/12/cytomegalovirus-harmfully-alters-immune-cell-populations-in-the-aging-immune-system

... cytomegalovirus is a common virus that can affect people of all ages. Symptoms include fever, sore throat, fatigue and swollen ... Cytomegalovirus: What the CDC wants you to know during the holiday. By Chris Williams. ... According to the CDC, cytomegalovirus is a common virus that can affect people of all ages. Symptoms include fever, sore throat ... Cytomegalovirus, it causes a mononucleosis syndrome. Image produced from an image taken with transmission electron microscopy. ...

https://www.fox5dc.com/news/cytomegalovirus-what-the-cdc-wants-you-to-know-during-the-holiday

Human cytomegalovirus infection - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ... Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is ...

https://www.kegg.jp/pathway/hsa05163/4985%09yellow/4986%09yellow/4988%09yellow/5742%09yellow/5743%09yellow

"Pre-Emptive Ganciclovir Therapy to Prevent Cytomegalovirus Disease in Cytomegalovirus Antibody-Positive Renal Transplant ... Cytomegalovirus infection is common in renal transplant recipients in the first 3 - 6 months after transplant [1]. Risk factors ... P. L. Hibberd and D. R. Snydman, "Cytomegalovirus Infection in Organ Transplant Recipients," Infectious Disease Clinics of ... N. Bagchi, P. Kumar, et al., "Cytomegalovirus Cholecystitis: A Case Report," Transplantation, Vol. 75, 2003, pp. 1918-1919. doi ...

https://file.scirp.org/Html/7-2070051_33305.htm

Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which ... Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset which ... Influence of human cytomegalovirus infection on the NK cell receptor repertoire in children. Eur J Immunol (2010) 40(5):1418-27 ... UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proc Natl Acad Sci U S A (2002) 99(11):7570-5 ...

https://www.frontiersin.org/articles/10.3389/fimmu.2017.01317/full

The purpose of this study is to determine if an investigational treatment (Maribavir) is safe and effective in treating transplant recipient patients with cytomegalovirus (CMV) infections that are refractory or resistant to treatment. (mayo.edu)
Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide which can bind with at least portions of the CMV RNA. (justia.com)
This invention relates to the design and synthesis of antisense oligonucleotides which can be administered to inhibit the replication of cytomegalovirus and treat cytomegalovirus infections. (justia.com)
Acute cytomegalovirus infections in leukemic mice. (jax.org)
September 25, 2012 (San Francisco, California) - An automated monitoring system for cytomegalovirus can slash the rate of serious cytomegalovirus infections, researchers reported here at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy. (medscape.com)
Cytomegalovirus infections are not only common but dangerous in transplant patients, Dr. da Cunha-Bang told Medscape Medical News . (medscape.com)
The incidence of cytomegalovirus infection remained statistically constant, at about 18%, over this time period ( P = .3), but the prevalence of moderate and severe infections decreased. (medscape.com)
Cytomegalovirus (CMV) is the most common cause of congenital viral infections . (bvsalud.org)
Infections with other viruses (e.g., cytomegalovirus, rubella, parvovirus) around the time of conception have been associated with congenital infection and adverse pregnancy outcomes, although the exact timing of infection relative to conception was sometimes uncertain ( 5 - 9 ). (cdc.gov)
It is used in the treatment of Cytomegalovirus (CMV) infections of the retina of the eye in patients with Acquired immune deficiency syndrome (AIDS). (mrmed.in)
Valstead 450mg Tablet is also used to prevent Cytomegalovirus (CMV) infections in patients who have received an organ transplant from a person who was infected with CMV and as prophylaxis for CMV in adults and children. (mrmed.in)

Also known as HCMV, CMV, or human herpesvirus 5 (HHV-5), cytomegalovirus is the most commonly transmitted virus to a developing fetus. (medicalnewstoday.com)
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. (kegg.jp)
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and functional features. (frontiersin.org)
In this regard, human cytomegalovirus (HCMV) infection has been shown to promote the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NKR (NKG2C bright ), together with additional distinctive phenotypic and functional features ( 7 - 12 ). (frontiersin.org)
Increasing indication in the past 10 years proposes that Epstein-Barr virus (EBV) and cytomegalovirus (HCMV) are related with some human malignancies including breast cancer. (scirp.org)
Amongst the set of 11 proteins which are required for human cytomegalovirus (HCMV) origin-dependent DNA synthesis, are six which are conserved amongst the herpesvirus family and which perform the essential functions required for viral DNA synthesis. (gla.ac.uk)

Congenital cytomegalovirus infection (cCMV) occurs when the CMV crosses the placenta during pregnancy and infects the fetus. (cdc.gov)
Photograph source: Işikay S, Yilmaz K. Congenital cytomegalovirus infection and finger anomaly. (cdc.gov)
There was no evidence of SARS-CoV-2 RNA in placenta and fetal tissue , but there was presence of congenital cytomegalovirus infection by nested PCR . (bvsalud.org)

In this thesis, I have sought to investigate the integrative process by studying the metabolic programming of macrophages infected with murine cytomegalovirus (MCMV) The central hypothesis of this thesis is that productive infection of macrophages by MCMV takes advantage of the early inflammatory metabolomic reprogramming of activated macrophages to establish infection, and modulates metabolism at late stages of infection towards fatty acid (FA) production to promote viral progeny. (bl.uk)
The hypothesis that MHC-specific activating NKR may contribute to the innate response against pathogens was supported by the evidence that Ly49H specifically interacts with the MHC class I-related murine cytomegalovirus glycoprotein m157, triggering NK cell effector functions and the development of a memory-like response that confers resistance against the viral infection in some mice strains ( 3 - 5 ). (frontiersin.org)
In this body of work, murine cytomegalovirus (MCMV) was used as an anti-tumor therapy and to model virus-specific tumor infiltrating lymphocytes (TIL). (jefferson.edu)
Erkes, Dan A, "Exploiting Murine Cytomegalovirus as an Anti-Tumor Therapy and Model for Virus-Specific Tumor Infiltrating Lymphocytes" (2016). (jefferson.edu)

Cytomegalovirus retinitis is a severe problem in immunosuppressed patients that often leads to blindness. (justia.com)
Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness. (bvsalud.org)

ATLANTA - The U.S. Centers for Disease Control and Prevention is issuing an alert about cytomegalovirus, or CMV, during the holiday. (fox5dc.com)

Background Ganciclovir/valganciclovir is currently indicated during the first 6 months of life in symptomatic children with congenital cytomegalovirus (CMV) infection. (bmj.com)

M45 is a 97-kDa virion-associated protein encoded by mouse cytomegalovirus (MCMV) (Krause et al. (com.hr)

Symptomatic cytomegalovirus infection in renal transplant recipients given either Minnesota antilymphoblast globulin (MALG) or OKT3 for rejection prophylaxis. (unh.edu)
To compare the impact of using Minnesota antilymphoblast globulin (MALG) versus the monoclonal antibody, OKT3, on the development of symptomatic cytomegalovirus (CMV) infection, we reviewed a cohort of 130 cadaveric renal transplant recipients enrolled in a prospective comparison of MALG versus OKT3 for rejection prophylaxis. (unh.edu)

CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ transplant. (centerwatch.com)
Early immune surveillance to predict cytomegalovirus outcomes after allogeneic hematopoietic stem cell transplantation Jintao Xia, et al. (journalfeeds.online)

An antiviral medication may be used to treat a cytomegalovirus infection in people whose immune systems are weakened or for transplant patients. (cincinnatichildrens.org)
The overall goal of this study is to determine the clinical benefit and safety of antiviral therapy for asymptomatic congenital cytomegalovirus (cCMV) infected hearing-impaired infants. (clinicaltrials.gov)
Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. (microbiologyresearch.org)
reveal a key detail in one of these stratagems, identifying a protein that enables cytomegalovirus to shut down an antiviral defense. (rupress.org)
Cytomegalovirus (CMV) viral load quantitation is important in the diagnosis, follow-up and monitoring of antiviral therapy in transplant patients. (pcr-pcr.com)

Chimerix announced final data from CMX001 Study 201, a Phase 2 study evaluating CMX001 for the prevention of cytomegalovirus in hematopoietic cell transplant recipients. (empr.com)

2022. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545048/all/Cytomegalovirus. (hopkinsguides.com)
Rapport d'activités 2022 de l'OMS Niger : principaux résultats de l'OMS atteints en étroite collaboration avec le Gouvernement, les partenaires et d'autres acteurs. (who.int)

We report a case of cytomegalovirus (CMV) disease complicating treatment with an IL-6 receptor antagonist. (cdc.gov)
Although the reduced-intensity conditioning allogeneic HSCT may avoid many of the organ toxicities associated with myeloablative conditioning, the risk for developing graft-versus-host disease and infection including cytomegalovirus remains significant. (causeweb.org)
The US Food and Drug Administration (FDA) has granted approval to Takeda Pharmaceutical's Livtencity (maribavir) to treat individuals aged 12 years and above with post-transplant cytomegalovirus (CMV) infection/disease. (pharmaceutical-technology.com)
These compounds can be used either prophylactically or therapeutically to reduce the severity of disease caused by cytomegaloviruses. (justia.com)
IMSEAR at SEARO: Cytomegalovirus disease. (who.int)
Cytomegalovirus disease. (who.int)
A monitoring program at Copenhagen University Hospital in Denmark cut hospital readmissions due to cytomegalovirus infection in solid organ transplant patients from 52% to 13%, reported Caspar da Cunha-Bang, MD, an infectious disease specialist at the hospital. (medscape.com)
Several agents are currently available for the treatment of cytomegalovirus (CMV) infection and disease. (medscape.com)
Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease. (rush.edu)

The primary outcome is presence of and time to cytomegalovirus (CMV) reactivation. (causeweb.org)
This study investigates whether donor KIR genotype influences reactivation of cytomegalovirus (CMV) after T-cell replete, matched sibling donor reduced-intensity conditioning allogeneic HSCT. (causeweb.org)
Cytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report. (bvsalud.org)

abstract = "Cytomegalovirus (CMV) infection is a common complication after liver transplantation, and it is associated with multiple direct and indirect effects. (elsevier.com)

If you are healthy and you get cytomegalovirus (CMV), you may not have any symptoms. (hse.ie)
For most people, cytomegalovirus (CMV) is an apparently innocuous persistent herpesvirus infection, one that presents no obvious symptoms. (fightaging.org)
Background: Common clinical manifestations of cytomegalovirus (CMV) infection include flu-like symptoms with fever, diarrhea, leukopenia, and elevated liver enzymes. (scirp.org)
What are the symptoms of cytomegalovirus? (nicklauschildrens.org)

Cytomegalovirus infection is common in renal transplant recipients in the first 3 - 6 months after transplant [1] . (scirp.org)
Symptomatic cytomegalovirus infection in renal transplant recipients g" by Thomas C. Bailey, William G. Powderly et al. (unh.edu)

Cytomegalovirus, it causes a mononucleosis syndrome. (fox5dc.com)
In the adult, cytomegalovirus-induced mononucleosis is a lingering illness that causes significant morbidity. (justia.com)

cytomegalovirus immune globulin (CMV IG) decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
efgartigimod alfa will decrease the level or effect of cytomegalovirus immune globulin (CMV IG) by receptor binding competition. (medscape.com)

Livtencity, which works by hindering human cytomegalovirus enzyme pUL97 activity, will be commercially available soon. (pharmaceutical-technology.com)
Kadhim A. L. Shadood, H. , Abdul-Aziz Atiya, S. and Ali Kardar, G. (2018) Correlation of Breast Cancer with the Epstein Bar Virus and Human Cytomegalovirus Frequency and the Expression of Estrogen Receptor-Beta and IL-6 Receptor in Iraqi Women. (scirp.org)
Human cytomegalovirus alters interleukin-6 production by endothelial cells. (microbiologyresearch.org)
In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed. (justia.com)
As a group, the human CMV isolates share at least 80% sequence homology, making it nearly impossible to classify cytomegaloviruses into subgroups or subtypes, although variations in the restriction endonuclease patterns of various CMV DNA preparations are identifiable in epidemiologically unrelated strains. (justia.com)
Study on sensitivity of Southern blotting hybridization using a 32P-labeled probe of PCR products in detecting human cytomegalovirus. (northwestern.edu)
In human primary RPE cells, SEAP secretion lasted at least 18 days when PDMAEMA-based micelles complexed with plasmid or minicircle with cytomegalovirus (CMV) promoter were used. (helsinki.fi)

Cytomegalovirus can be diagnosed using a simple blood test that looks for antibodies against the virus or by measuring actual CMV viral levels in the blood. (verywellhealth.com)

Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. (nih.gov)
Cytomegalovirus, which most people contract at some point in their lives, eludes immune system surveillance by targeting the protein MHC I. When we're sick, MHC I captures bits of viral proteins and presents them to cytotoxic T cells, which respond by killing cells that harbor the virus, stanching the infection. (rupress.org)

Evidence-based recommendations on maribavir (Livtencity) for cytomegalovirus infection in adults after transplant. (bvsalud.org)

Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2 , Epstein-Barr virus , and varicella-zoster virus . (medscape.com)

Other viruses, such as cytomegalovirus , can sometimes cause a mono-like illness too. (childrensdayton.org)
Hepatitis viruses are from A to G and some other viruses include cytomegalovirus, Epstein - Barr virus, yellow fever, etc. (healthwatchcenter.com)

OBJECTIVES: To assess whether preterm infants with postnatal cytomegalovirus infection develop neurologic sequelae in early childhood. (uu.nl)

Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS . (bvsalud.org)

Cytomegalovirus is a kind of herpes virus that causes infection in patients following a stem cell or organ transplant. (pharmaceutical-technology.com)

Cytomegalovirus (CMV)-based vaccines have shown remarkable efficacy in the rhesus macaque model of acquired immune deficiency syndrome, enabling 50% of vaccinated monkeys to clear a subsequent virulent simian immunodeficiency virus challenge. (elsevier.com)

Association of early-life stress with cytomegalovirus infection in adults with major depressive disorder [published online March 6, 2019]. (psychiatryadvisor.com)

Copenhagen University Hospital has monitored cytomegalovirus infection in transplant patients for years, but the different departments in the hospital did not coordinate their efforts, Dr. da Cunha-Bang explained. (medscape.com)

Available at https://www.causeweb.org/tshs/cytomegalovirus/ . (causeweb.org)

Please refer to this resource as: Amy S. Nowacki, "Cytomegalovirus Dataset", TSHS Resources Portal (2017) . (causeweb.org)

CONCLUSIONS: In this cohort study, postnatal cytomegalovirus infection in preterm children did not have an adverse effect on neurodevelopment within the first 6 years of life. (uu.nl)

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. (bvsalud.org)

Cytomegalovirus (CMV) colitis, on the other hand, is generally diagnosed in immunosuppressed patients and is rare in immunocompetent patients. (lww.com)
Although cytomegalovirus may play a role in the progression of HIV infection to AIDS by stimulating the transcription of the HIV long terminal repeats (LTR) in nontransformed co-infected T cells, histologic examination of adrenals and brains from AIDS patients has suggested that the adrenalitis, encephalitis and peripheral neuropathy were caused by CMV infection. (justia.com)
To evaluate the effectiveness of the MATCH program, Dr. da Cunha-Bang and colleagues tracked patients with cytomegalovirus for the 2 years before the implementation of the program (2007 and 2008), the 2 years during implementation (2009 and 2010), and the year after it was implemented (2011). (medscape.com)

Cytomegalovirus is only spread through contact with an infected person's body fluids, such as saliva, blood, urine, or breast milk. (cincinnatichildrens.org)
Among participants aged 6-49 years in NHANES between 1999 and 2004 who were cytomegalovirus (CMV) IgG positive, had stored urine samples available, tested and found with urinary CMV shedding and sufficient DNA for genotyping. (cdc.gov)

The donor pancreas is retrieved en bloc with the duodenum, which is transected and stapled proximally just beyond the pylorus and distally in the third part of the duodenum. (springeropen.com)

Dr. Mitchell Essig, Medical Director of Cryos International NY, talks about the risks of pregnancy and cytomegalovirus (CMV). (checkorphan.org)

Cytomegalovirus (CMV) is a very common herpesviridae virus. (cdc.gov)
Cytomegalovirus CMV, a DNA virus from Herpesviridae family. (iflscience.com)
Género de la familia HERPESVIRIDAE, subfamilia BETAHERPESVIRINAE, que infecta las glándulas salivales, el hígado, el bazo, los pulmones, los ojos y otros órganos en los cuales produce células característicamente grandes, con inclusiones intranucleares. (bvsalud.org)

Gross specimen of bowel showing ulceration secondary to cytomegalovirus colitis. (medscape.com)
Giant cell with inclusion body characteristic of cytomegalovirus colitis. (medscape.com)
Concurrent Cytomegalovirus Colitis and Gastrointestinal Amyl. (lww.com)

Cytomegalovirus (CMV) is a virus found around the world. (medlineplus.gov)
Cytomegalovirus is a common herpes virus. (medicalnewstoday.com)
Cytomegalovirus (CMV) is a common virus that infects most people during their life. (cincinnatichildrens.org)
Cytomegalovirus (CMV) is a common virus that can infect almost anyone. (causeweb.org)
According to the CDC, cytomegalovirus is a common virus that can affect people of all ages. (fox5dc.com)
Congenital cytomegalovirus is a condition that can occur when an infant is infected with a virus called cytomegalovirus (CMV) before birth. (adam.com)
Cytomegalovirus is a common virus that, once contracted, stays in the body for life. (nicklauschildrens.org)
After 2 consecutive cytomegalovirus polymerase chain reaction assays finding more than 300 copies/mL of the virus, a patient was considered to be infected. (medscape.com)

Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8 + CD57 + population than in the CD8 + CD57 - population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ + , tumor necrosis factor-α + , or CD107a + cells in the CD8 + T-cell subset was independently correlated with pulse wave velocity as well. (nih.gov)
The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated. (nih.gov)
Chronic infection especially by cytomegalovirus (CMV) has a dramatic influence on the T-cell compartment, both on CD8 + and CD4 + T-cells. (fightaging.org)
However, two cytomegalovirus genes dupe cells into ubiquitinating MHC I and demolishing it in the proteasome, the cellular garbage disposal. (rupress.org)
MAB detection of Cytomegalovirus (CMV) in infected MEF-K cells by indirect fluorescence method using FITC-conjugated anti-mouse secondary antibody. (com.hr)

Rapid Genotyping of Cytomegalovirus in Dried Blood Spots by Multiplex Real-Time PCR Assays Targeting the Envelope Glycoprotein gB and gH Genes 2012. (cdc.gov)

Anatomy11

Organisms12

Diseases14

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes28

Disciplines and Occupations1

Information Science3

Named Groups2

Health Care2

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (1/5460)

Cytomegalovirus seropositivity and incident ischaemic heart disease in the Caerphilly prospective heart disease study. (2/5460)

Detection of Chlamydia pneumoniae but not cytomegalovirus in occluded saphenous vein coronary artery bypass grafts. (3/5460)

Evaluation of fibroblast-mediated gene therapy in a feline model of mucopolysaccharidosis type VI. (4/5460)

The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation. (5/5460)

Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. (6/5460)

Reversing adipocyte differentiation: implications for treatment of obesity. (7/5460)

Human herpesviruses in chronic fatigue syndrome. (8/5460)

Cytomegalovirus

Cytomegalovirus Infections

Cytomegalovirus Retinitis

Muromegalovirus

Cytomegalovirus Vaccines

Ganciclovir

Immediate-Early Proteins

DNA, Viral

Viral Proteins

Herpesviridae Infections

Antiviral Agents

Foscarnet

Antigens, Viral

Virus Replication

Antibodies, Viral

Genes, Immediate-Early

Viral Matrix Proteins

Gene Expression Regulation, Viral

Viral Envelope Proteins

Fibroblasts

Virus Activation

Cell Line

Genes, Viral

Roseolovirus

Molecular Sequence Data

Cells, Cultured

Herpesviridae

AIDS-Related Opportunistic Infections

Polymerase Chain Reaction

Viremia

Organ Transplantation

Herpesvirus 6, Human

Base Sequence

Viral Plaque Assay

Betaherpesvirinae

Pneumonia, Viral

Immunocompromised Host

Ribonucleosides

Phosphoproteins

Immunocompetence

Retinitis

Kidney Transplantation

Acyclovir

Eye Infections, Viral

Opportunistic Infections

Cytopathogenic Effect, Viral

Promoter Regions, Genetic

Viral Load

Complement Fixation Tests

Virus Latency

Pregnancy Complications, Infectious

Mice, Inbred BALB C

Salivary Glands

Virology

Amino Acid Sequence

Genome, Viral

Transplantation, Homologous

Open Reading Frames

Immunoglobulin M

Immunoglobulin G

Organophosphonates

Inclusion Bodies, Viral

Time Factors

Genetic Vectors

Fluorescent Antibody Technique

Virion

Acquired Immunodeficiency Syndrome

CD8-Positive T-Lymphocytes

Virus Cultivation

Phosphotransferases (Alcohol Group Acceptor)

Urine

Cytosine

Roseolovirus Infections

Transcription, Genetic

Membrane Glycoproteins

Transplantation

Chromosomes, Artificial, Bacterial

Bone Marrow Transplantation

Trans-Activators

RNA, Viral

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