A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. Murid herpesvirus is the type species.
Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Proteins found in any species of virus.
Virus diseases caused by the HERPESVIRIDAE.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Substances elaborated by viruses that have antigenic activity.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Established cell cultures that have the potential to propagate indefinitely.
The functional hereditary units of VIRUSES.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, whose viruses have been isolated from lymphocytes. HERPESVIRUS 6, HUMAN is the type species.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The presence of viruses in the blood.
Transference of an organ between individuals of the same species or between individuals of different species.
The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.
Inflammation of the lung parenchyma that is caused by a viral infection.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.
Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).
The transference of a kidney from one human or animal to another.
A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Elements of limited time intervals, contributing to particular results or situations.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Process of growing viruses in live animals, plants, or cultured cells.
A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
A pyrimidine base that is a fundamental unit of nucleic acids.
Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Glycoproteins found on the membrane or surface of cells.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Ribonucleic acid that makes up the genetic material of viruses.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
The transference of either one or both of the lungs from one human or animal to another.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
An infant during the first month after birth.
A general term for diseases produced by viruses.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.
A species in the genus ROSEOLOVIRUS, of the family HERPESVIRIDAE. It was isolated from activated, CD4-positive T-lymphocytes taken from the blood of a healthy human.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
The interactions between a host and a pathogen, usually resulting in disease.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.
Antibodies produced by a single clone of cells.
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
The transference of a part of or an entire liver from one human or animal to another.
An inhibitory subclass of NK cell lectin-like receptors that interacts with CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS and prevents the activation of NK CELLS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Diagnostic procedures involving immunoglobulin reactions.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The process by which a DNA molecule is duplicated.

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (1/5460)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

Cytomegalovirus seropositivity and incident ischaemic heart disease in the Caerphilly prospective heart disease study. (2/5460)

OBJECTIVE: To assess the role of cytomegalovirus (CMV) infection in primary ischaemic heart disease. METHODS: Plasma specimens collected during 1979-83 from men in Caerphilly, south Wales, were analysed for IgG antibodies to CMV by enzyme linked immunosorbent assay and latex tests. Incident ischaemic heart disease events were ascertained after five and 10 years from death certificates, hospital records, and ECG changes; 195 incident ischaemic heart disease cases were compared with 216 controls of a similar age drawn from the rest of the cohort. RESULTS: 164 cases (84%) and 180 controls (83%) were seropositive for CMV. Optical density, an indicator of CMV antibody titre, was similar for cases and controls. Among controls, seropositivity was not associated with age, socioeconomic status currently or in childhood, smoking, height, body mass index, blood pressure, total cholesterol, fibrinogen, plasma viscosity, or leucocyte count. The unadjusted odds ratio relating CMV seropositivity to incident ischaemic heart disease was 1.06 (95% confidence interval 0.63 to 1.79) and was little changed (1.11, 0.63 to 1.97) after adjustment for age, smoking, body mass index, systolic blood pressure, total cholesterol, and socioeconomic status currently and in childhood. CONCLUSIONS: CMV infection is unlikely to be a strong risk factor for development of myocardial infarction in middle aged men.  (+info)

Detection of Chlamydia pneumoniae but not cytomegalovirus in occluded saphenous vein coronary artery bypass grafts. (3/5460)

BACKGROUND: A causal relation between atherosclerosis and chronic infection with Chlamydia pneumoniae and/or cytomegalovirus (CMV) has been suggested. Whether the unresolved problem of venous coronary artery bypass graft occlusion is related to infection with C pneumoniae and/or CMV has not been addressed. METHODS AND RESUTLS: Thirty-eight occluded coronary artery vein grafts and 20 native saphenous veins were examined. Detection of C pneumoniae DNA was performed by use of nested polymerase chain reaction (PCR). Homogenisates from the specimen were cultured for identification of viable C pneumoniae. Both conventional PCR and quantitative PCR for detection of CMV DNA were applied. Differential pathological changes (degree of inflammation, smooth muscle cell proliferation [MIB-1]) were determined and correlated to the detection of both microorganisms. C pneumoniae DNA could be detected in 25% of occluded vein grafts. Viable C pneumoniae was recovered from 16% of occluded vein grafts. Except for 1 native saphenous vein, all control vessels were negative for both C pneumoniae detection and culture. All pathological and control specimens were negative for CMV DNA detection. Pathological changes did not correlate with C pneumoniae detection. CONCLUSIONS: Occluded aorto-coronary venous grafts harbor C pneumoniae but not CMV. The detection of C pneumoniae in occluded vein grafts warrants further investigation.  (+info)

Evaluation of fibroblast-mediated gene therapy in a feline model of mucopolysaccharidosis type VI. (4/5460)

Fibroblast-mediated ex vivo gene therapy was evaluated in the N-acetylgalactosamine 4-sulfatase (4S) deficient mucopolysaccharidosis type VI (MPS VI) cat. Skin biopsies were obtained at birth from severely affected MPS VI kittens and used to initiate fibroblast outgrowths for retroviral transduction with the 4S cDNA. 4S gene expression in transduced cells was under the transcriptional control of the MoMLV long terminal repeat promoter or the cytomegalovirus (CMV) immediate-early promoter. Characterisation of gene-transduced fibroblasts demonstrated the cells to be over-expressing 4S activity. Twenty-four to forty million autologous, gene-corrected fibroblasts were implanted under the renal capsule of three MPS VI kittens at 8-16 weeks of age. Transient, low levels of 4S activity were detected in peripheral blood leukocytes shortly after implantation but were not detectable within 3-8 weeks' post-implantation. Long-term biochemical and clinical evaluation of these cats demonstrated identical disease progression to that previously described in untreated, clinically severe MPS VI cats.  (+info)

The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation. (5/5460)

At our institution, the cytomegalovirus (CMV) prophylaxis protocol for allogeneic bone marrow transplant (BMT) recipients who are CMV-seropositive or receive marrow from a CMV-seropositive donor consists of a surveillance bronchoscopy approximately 35 days posttransplant. Patients with a positive surveillance bronchoscopy for CMV receive pre-emptive ganciclovir. In order to determine the utility of other screening methods for CMV, we prospectively performed weekly CMV antigenemia, and blood, urine and throat cultures from time of engraftment to day 120 post-BMT in 126 consecutive patients. Pre-emptive ganciclovir was given to 11/81 patients (13.6%) because of a positive surveillance bronchoscopy for CMV. Results of CMV blood, urine and throat cultures and the antigenemia assay done prior to or at the time of the surveillance bronchoscopy were analyzed for their ability to predict the bronchoscopy result. The antigenemia test had the highest positive and negative predictive values (72% and 96%, respectively). The ability of these tests to predict CMV disease was evaluated in the 70 patients with a negative surveillance bronchoscopy who did not receive pre-emptive ganciclovir. Of 19 cases of active CMV disease, CMV antigenemia was positive in 15 patients (79%) a mean of 34 days preceding symptoms. Blood cultures were positive in 14/19 patients (74%) a mean of 31 days before onset of disease. CMV antigenemia is useful for predicting the surveillance bronchoscopy result, and also predicts the development of CMV disease in the majority of patients missed by the surveillance bronchoscopy.  (+info)

Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. (6/5460)

Cidofovir is the first nucleoside monophosphate analogue currently being used for the treatment of human cytomegalovirus (HCMV) retinitis in individuals with AIDS. Unfortunately, the period of therapy with the use of this compound may be limited due to the possible emergence of serious irreversible nephrotoxic effects. New drugs with improved toxicity profiles are needed. The goal of this study was to investigate the anticytomegaloviral properties and drug-induced toxicity of a novel phosphonate analogue, namely, (-)-2-(R)-dihydroxyphosphinoyl-5-(S)-(guanin-9'-yl-methyl) tetrahydrofuran (compound 1), in comparison with those of cidofovir. The inhibitory activities of both compounds on HCMV propagation in vitro were similar against the AD 169 and Towne strains, with 50% inhibitory concentrations ranging from 0.02 to 0.17 microgram/ml for cidofovir and < 0.05 to 0.09 microgram/ml for compound 1. A clinical HCMV isolate that was resistant to ganciclovir and that had a known mutation within the UL54 DNA polymerase gene and a cidofovir-resistant laboratory strain derived from strain AD 169 remained sensitive to compound 1, whereas their susceptibilities to ganciclovir and cidofovir were reduced by 33- and 10-fold, respectively. Both compound 1 and cidofovir exhibited equal potencies in an experimentally induced murine cytomegalovirus (MCMV) infection in mice, with a prevention or prolongation of mean day to death at dosages of 1.0, 3.2, and 10.0 mg/kg of body weight/day. In cytotoxicity experiments, compound 1 was found to be generally more toxic than cidofovir in cell lines Hs68, HFF, and 3T3-L1 (which are permissive for HCMV or MCMV replication) but less toxic than cidofovir in MRC-5 cells (which are permissive for HCMV replication). Drug-induced toxic side effects were noticed for both compounds in rats and guinea pigs in a 5-day repeated-dose study. In guinea pigs, a greater weight loss was noticed with cidofovir than with compound 1 at dosages of 3.0 and 10.0 mg/kg/day. An opposite effect was detected in rats, which were treated with the compounds at relatively high dosages (up to 100 mg/kg/day). Compound 1 and cidofovir were nephrotoxic in both rats and guinea pigs, with the epithelium lining the proximal convoluted tubules in the renal cortex being the primary target site. The incidence and the severity of the lesions were found to be dose dependent. The lesions observed were characterized by cytoplasm degeneration and nuclear modifications such as karyomegaly, the presence of pseudoinclusions, apoptosis, and degenerative changes. In the guinea pig model, a greater incidence and severity of lesions were observed for cidofovir than for compound 1 (P < 0.001) with a drug regimen of 10 mg/kg/day.  (+info)

Reversing adipocyte differentiation: implications for treatment of obesity. (7/5460)

Conventional treatment of obesity reduces fat in mature adipocytes but leaves them with lipogenic enzymes capable of rapid resynthesis of fat, a likely factor in treatment failure. Adenovirus-induced hyperleptinemia in normal rats results in rapid nonketotic fat loss that persists after hyperleptinemia disappears, whereas pair-fed controls regain their weight in 2 weeks. We report here that the hyperleptinemia depletes adipocyte fat while profoundly down-regulating lipogenic enzymes and their transcription factor, peroxisome proliferator-activated receptor (PPAR)gamma in epididymal fat; enzymes of fatty acid oxidation and their transcription factor, PPARalpha, normally low in adipocytes, are up-regulated, as are uncoupling proteins 1 and 2. This transformation of adipocytes from cells that store triglycerides to fatty acid-oxidizing cells is accompanied by loss of the adipocyte markers, adipocyte fatty acid-binding protein 2, tumor necrosis factor alpha, and leptin, and by the appearance of the preadipocyte marker Pref-1. These findings suggest a strategy for the treatment of obesity by alteration of the adipocyte phenotype.  (+info)

Human herpesviruses in chronic fatigue syndrome. (8/5460)

We have conducted a double-blind study to assess the possible involvement of the human herpesviruses (HHVs) HHV6, HHV7, Epstein-Barr virus (EBV), and cytomegalovirus in chronic fatigue syndrome (CFS) patients compared to age-, race-, and gender-matched controls. The CFS patient population was composed of rigorously screened civilian and Persian Gulf War veterans meeting the Centers for Disease Control and Prevention's CFS case definition criteria. Healthy control civilian and veteran populations had no evidence of CFS or any other exclusionary medical or psychiatric condition. Patient peripheral blood mononuclear cells were analyzed by PCR for the presence of these HHVs. Using two-tailed Fisher's exact test analyses, we were unable to ascertain any statistically significant differences between the CFS patient and control populations in terms of the detection of one or more of these viruses. This observation was upheld when the CFS populations were further stratified with regard to the presence or absence of major axis I psychopathology and patient self-reported gradual versus acute onset of disease. In tandem, we performed serological analyses of serum anti-EBV and anti-HHV6 antibody titers and found no significant differences between the CFS and control patients.  (+info)

TY - JOUR. T1 - Different antibody response to a neutralizing epitope of human cytomegalovirus glycoprotein B among seropositive individuals. AU - Ayata, Minoru. AU - Sugano, Tohru. AU - Murayama, Tsugiya. AU - Sakamuro, Daitoku. AU - Takegami, Tsutomu. AU - Matsumoto, Yoh‐Ichi ‐I. AU - Furukawa, Toru. PY - 1994/8. Y1 - 1994/8. N2 - The amino‐terminal portion of human cytomeg‐alovirus glycoprotein B (HCMV‐gB) was expressed as a fusion protein to analyze the neutralizing epitope recognized by human monoclonal antibody C23 and the humoral immune response to this epitope. The linear neutralizing epitope was further localized to the pep‐tide within 17 amino acids (position 68‐84) which were conserved between two HCMV laboratory strains. Ten out of 17 HCMV‐seropositive human sera contained the antibody against this epitope. Although seven sera were negative for reacting with the fusion protein, the viruses isolated from the same patients retained the epitope. The immunogenicity of the ...
The repression of human cytomegalovirus immediate-early (IE) lytic gene expression is crucial for the maintenance of the latent viral state. By using conditionally permissive cell lines, which provide a good model for the differentiation state-dependent repression of IE gene expression, we have identified several cellular factors that bind to the major immediate-early promoter (MIEP) and whose expression is down-regulated after differentiation to a permissive phenotype. Here we show that the cellular protein Ets-2 Repressor Factor (ERF) physically interacts with the MIEP and represses MIEP activity in undifferentiated non-permissive T2 embryonal carcinoma cells. This factor binds to the dyad element and the 21 bp repeats within the MIEP - regions known to be important for the negative regulation of MIEP activity. Finally, we show that following differentiation to a permissive phenotype ERF's repressive effects are severely abrogated.
TY - JOUR. T1 - Monitoring of ganciclovir sensitivity of multiple human cytomegalovirus strains coinfecting blood of an AIDS patient by an immediate-early antigen plaque assay. AU - Gerna, Giuseppe. AU - Baldanti, Fausto. AU - Zavattoni, Maurizio. AU - Sarasini, Antonella. AU - Percivalle, Elena. AU - Revello, M. Grazia. PY - 1992/10/1. Y1 - 1992/10/1. N2 - A plaque-reduction assay for chemosensitivity testing of human cytomegalovirus (HCMV) strains was developed based on early detection of viral plaques 96 h p.i. by a monoclonal antibody to the major immediate-early protein p72. Sequential HCMV isolates from an AIDS patient undergoing multiple courses of ganciclovir treatment during an 18-month follow-up were tested by the new assay, showing emergence of a ganciclovir-resistant strain. However, cloning of viral isolates and Southern blot hybridization analysis showed the simultaneous presence of three different HCMV strains in blood. Of these, the resistant strain was likely to be selected ...
In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously reported that a 70% ethanol extract of Elaeocarpus sylvestris leaves (ESE) inhibits human cytomegalovirus (HCMV) replication in vitro. In the present study, we determined the solvent fraction of ESE that inhibits HCMV replication using activity-guided fractionation. Activity-guided fractionation of ESE was performed to determine the solvent fraction that inhibits HCMV replication. Effects of solvent fractions on HCMV lytic gene expression and major immediate-early (MIE) enhancer/promoter activity were further investigated. Among the solvent fractions tested, the EtOAc fraction of ESE markedly reduced HCMV lytic gene expression and viral replication in vitro without exerting significant cytotoxic effects against human foreskin fibroblasts (HFF). Furthermore, the EtOAc fraction negatively affected
HCMV is the leading infectious cause of mental retardation and deafness in infants with congenital HCMV infection. Primary HCMV infections during pregnancy carry the highest risk of fetal infection and disease. No intervention of proven efficacy is available in case of primary HCMV infection in pregnancy. However, a study published in 2005 (Nigro et al., NEJM 353:1350-62, 2005) reported that in pregnant women with primary HCMV infection treated with HCMV-specific hyperimmune globulin (Cytotect®, Biotest) the risk of transmitting the infection to the fetus was reduced from 40% to 16%. Unfortunately, since the study was conducted with inadequate controls, the actual efficacy of hyperimmune globulin could not be properly assessed.. In the present randomized, double-blind, placebo-controlled, multicenter trial pregnant women with ascertained primary HCMV infection at 4-26 weeks of gestation will be randomized to receive Cytotect® or placebo intravenously within 6 weeks after the presumed onset of ...
1. CroughT, KhannaR (2009) Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 22: 76-98.. 2. DeaytonJR, Prof SabinCA, JohnsonMA, EmeryVC, WilsonP, et al. (2004) Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet 363: 2116-2121.. 3. BuonsensoD, SerrantiD, GargiulloL, CeccarelliM, RannoO, et al. (2012) Congenital cytomegalovirus infection: current strategies and future perspectives. Eur Rev Med Pharmacol Sci 16: 919-935.. 4. GrattanMT, Moreno-CabralCE, StarnesVA, OyerPE, StinsonEB, et al. (1989) Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis. Jama 261: 3561-3566.. 5. KuvinJT, KimmelstielCD (1999) Infectious causes of atherosclerosis. Am Heart J 137: 216-226.. 6. MelnickJL, AdamE, DebakeyME (1993) Cytomegalovirus and atherosclerosis. Eur Heart J 14 Suppl K: 30-38.. 7. MuhlesteinJB, HorneBD, CarlquistJF, MadsenTE, ...
Background & Objectives: Interaction of cytomegalovirus glycoprotein B with toll-like receptors of dendritic cells leads to early signaling and innate immune responses. The aim of this study is to evaluate the effects of cytomegalovirus glycoprotein B on the maturation and function of monocyte-derived dendritic cells in treated groups in comparison with control ...
Human cytomegalovirus (HCMV) manipulates many aspects of host cell biology to create an intracellular milieu optimally supportive of its replication and spread. Our study reveals that levels of several components of the purinergic signaling system, including the P2Y2 and P2X5 receptors, are elevated in HCMV-infected fibroblasts. Knockdown and drug treatment experiments demonstrated that P2Y2 enhances the yield of virus, whereas P2X5 reduces HCMV production. The HCMV IE1 protein induces P2Y2 expression; and P2Y2-mediated signaling is important for efficient HCMV gene expression, DNA synthesis, and the production of infectious HCMV progeny. P2Y2 cooperates with the viral UL37x1 protein to regulate cystolic Ca2+ levels. P2Y2 also regulates PI3K/Akt signaling and infected cell motility. Thus, P2Y2 functions at multiple points within the viral replication cycle to support the efficient production of HCMV progeny, and it may facilitate in vivo viral spread through its role in cell migration. ...
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that has been implicated in several disorders, including an association between HCMV reactivation and the overproliferation of arterial smooth muscle cells observed in restenosis. Although HCMV can mediate a growth-arrest phenotype in infected cells, the virus can also promote an environment conducive to proliferation. Here, we present evidence that the HCMV immediate-early (IE) proteins, IE1-72 and IE2-86, may be responsible for inducing this proliferative environment by altering cell cycle control. We find that expression of either of these IE proteins can alter the cell cycle distribution of randomly cycling cells towards S and G(2)/M phases. Additionally, we find that expression of IE2-86, but not IE1-72, induces quiescent cells into S phase and delays cell cycle exit. In the absence of p53, IE1-72 expression can induce S phase and delay cell cycle exit. We also demonstrate that p53 protein levels increase in fibroblasts following the
TY - JOUR. T1 - Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry. AU - Luganini, Anna. AU - Caposio, Patrizia. AU - Landolfo, Santo. AU - Gribaudo, Giorgio. PY - 2008/3. Y1 - 2008/3. N2 - Studies in animal models have provided evidence that Toll-like receptor 9 (TLR9) agonists, such as synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory deoxycytidyl-deoxyguanosine (CpG) motifs (CpG ODNs), protect against a wide range of viral pathogens. This antiviral activity has been suggested to be indirect and secondary to CpG-induced cytokines and inflammatory responses triggered through TLR9 activation. However, few studies have addressed the potential of CpG ODNs as direct antiviral agents. Here, we report on the ability of some CpG ODNs to directly suppress, almost completely, human cytomegalovirus (HCMV) replication in both primary fibroblasts and endothelial cells. Murine CMV replication was inhibited as well, whereas no ...
Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system.
Original Article. Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the prenatal period. Ster, B.... Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2, Epstein Barr virus, and varicella zoster virus. Vid W. Chronic inflammation may be a causative factor in a variety of cancers. Mberlin, M. Review. Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the prenatal period. General, the longer the inflammation persists, the higher the risk of cancer. Systematic review of publications indexed in the PubMed database was performed for HSCT studies. General, the longer the inflammation persists, the higher the risk of cancer. 8ajg. Otein Losing Enteropathy: Case Illustrations and. Ablo J. J Gastroenterol 2010; 105:4349; doi:10. Chronic inflammation may be a causative factor in a variety of cancers. Lganciclovir for Symptomatic Congenital Cytomegalovirus ...
The genomes of DNA tumor viruses regain nuclear localization after nuclear envelope breakdown during mitosis through the action of a viral protein with a chromatin-tethering domain (CTD). Here, we report that the human cytomegalovirus (HCMV) genome is maintained during mitosis by the CTD of the viral IE19 protein. Deletion of the IE19 CTD or disruption of the IE19 splice acceptor site reduced viral genome maintenance and progeny virion formation during infection of dividing fibroblasts, both of which were rescued by IE19 ectopic expression. The discovery of a viral genome maintenance factor during productive infection provides new insight into the mode of HCMV infection implicated in birth defects, organ transplant failure, and cancer.. IMPORTANCE Human cytomegalovirus (HCMV) is the leading infectious cause of birth defects, represents a serious complication for immunocompromised HIV/AIDS and organ transplant patients, and contributes to both immunosenescence and cardiovascular diseases. HCMV is ...
TY - JOUR. T1 - Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses. AU - Kim, Youngkyun. AU - Park, Boyoun. AU - Cho, Sunglim. AU - Shin, Jinwook. AU - Cho, Kwangmin. AU - Jun, Youngsoo. AU - Ahn, Kwangseog. PY - 2008/8/1. Y1 - 2008/8/1. N2 - Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis. HCMV expresses UL18, a MHC class I homolog that functions as a surrogate to prevent host cell lysis. Despite a high level of sequence and structural homology between UL18 and MHC class I molecules, surface expression of MHC class I, but not UL18, is down regulated by US6. Here, we describe a mechanism of action by which HCMV UL18 avoids attack by the self-derived TAP inhibitor US6. UL18 abrogates US6 inhibition of ATP binding by TAP and, thereby, restores TAP-mediated peptide translocation. In addition, UL18 together ...
Life-threatening opportunistic cytomegalovirus infection is a complication of the acquired immunodeficiency syndrome (AIDS) that occurs in 7.4% or more of patients with AIDS. Cytomegalovirus retinitis, colitis, esophagitis, and gastritis are the commonest manifestations of severe cytomegalovirus end-organ disease. Extensive trials with intravenous ganciclovir, a nucleoside analogue with myelosuppressive toxicity, have shown that ganciclovir halts the progression of cytomegalovirus retinitis and gastrointestinal disease. Since relapse is common when therapy is discontinued, most patients with AIDS need lifelong maintenance therapy. The clinical response to ganciclovir therapy is usually accompanied by diminished shedding of the virus. Based on limited data, foscarnet, a pyrophosphate analogue, also appears to have some efficacy in treating cytomegalovirus infection. Unlike ganciclovir, foscarnet does not cause myelosuppression. An important direction for future clinical research is the ...
Objective Human cytomegalovirus (HCMV) is an important infectious factor that results in neonatal disease and congenital deformity. HCMV may invade many organs. The different symptoms and tissue tropism of HCMV infection perhaps result from the genetic polymorphism of HCMV. Recent study showed that Toledo genome contained 19 open reading frames (denoted UL131 to 151) which were not present in the AD169 genome, leading us to focus on the relationship between HCMV disease and the products of these 19 open reading frames. UL144 open reading frames encode a homologue of the tumor necrosis factor receptor. It seems important to study the strain-specific variability of UL144 sequence in low-passage clinical isolates and to discuss if the variability related to the clinical HCMV infection. Methods HCMV-UL144 gene was amplified by PCR assay in 65 low-passage clinical isolates and urine from 7 healthy children, which were HCMV-DNA positive as shown by QPCR. All the positive PCR products were analyzed by HMA
TY - JOUR. T1 - Detection of cytomegalovirus genomes in human skin fibroblasts by DNA hybridization. AU - Williams, L. L.. AU - Blakeslee, J. R.. AU - Boldogh, Istvan. AU - Huang, E. S.. PY - 1980. Y1 - 1980. N2 - A previous isolation of a human cytomegalovirus (CMV) from fibroblasts derived from intact skin of a Charcot-Marie-Tooth disease patient has prompted examination of six blind-coded cultured human skin lines by CMV DNA hybridization. The detection of CMV genome equivalents in three of the lines suggests that, in some cases, intact human skin may be a site of CMV latency.. AB - A previous isolation of a human cytomegalovirus (CMV) from fibroblasts derived from intact skin of a Charcot-Marie-Tooth disease patient has prompted examination of six blind-coded cultured human skin lines by CMV DNA hybridization. The detection of CMV genome equivalents in three of the lines suggests that, in some cases, intact human skin may be a site of CMV latency.. UR - ...
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Human cytomegalovirus (HCMV) is a frequent cause of major disease following primary infection or reactivation from latency in immunocompromised patients. Infection of non-permissive mononuclear cells is used for analyses of HCMV latency in vitro. Using this approach, it is shown here that repression of lytic gene expression following experimental infection of CD34+ cells, a site of HCMV latency in vivo, correlates with recruitment of repressive chromatin around the major immediate-early promoter (MIEP). Furthermore, long-term culture of CD34+ cells results in carriage of viral genomes in which the MIEP remains associated with transcriptionally repressive chromatin. Finally, specific differentiation of long-term cultures of infected CD34+ cells to mature dendritic cells results in acetylation of histones bound to the MIEP, concomitant loss of heterochromatin protein 1 and the reactivation of HCMV. These data are consistent with ex vivo analyses of latency and may provide a model for further analyses of
Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains used for research. To generate a genetically intact source of HCMV, we cloned strain Merlin into a sel …
persons body, it may or may not result in the active disease. Once in the body, such virus can be dormant for many years, but becomes active and can result in the disease at any time.. Between 60 and 90% of adults have experienced Cytomegalovirus infection at one point of their lives; although, these people experience no symptoms. A severe infection usually happens only in individuals, who have impaired immune systems (for instance, patients with AIDS).. Cytomegalovirus infections before birth can result in stillbirth, miscarriage and may be fatal for newborns. Cytomegalovirus may be life-threatening, if extensive brain or liver damage, anemia, or bleeding, occurs. Many individuals, who get the Cytomegalovirus infection after birth and harbor such a virus, experience no symptoms. However, a healthy individual with the infection can have a fever and feel ill.. If an individual receives blood transfusion consisting of cytomegalovirus, symptoms can start two to four weeks later. Such symptoms ...
The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly from clinical pathology samples were investigated, focusing on variation, multiple-strain infection, recombination, and gene loss. A total of 207 datasets generated in this and previous studies using target enrichment and high-throughput sequencing were analyzed, in the process enabling the determination of genome sequences for 91 strains. Key findings were that (i) it is important to monitor the quality of sequencing libraries in investigating variation; (ii) many recombinant strains have been transmitted during HCMV evolution, and some have apparently survived for thousands of years without further recombination; (iii) mutants with nonfunctional genes (pseudogenes) have been circulating and recombining for long periods and can cause congenital infection and resulting clinical sequelae; and (iv) intrahost variation in single-strain infections is much less than that in multiple-strain infections. Future ...
Human cytomegalovirus (HCMV) is the most significant microbial cause of birth defects, including brain damage and deafness, in developed nations. There is a compelling argument that a reduction in HCMV load would provide significant benefit in improving human health and reducing health care costs. Vaccination is the most practical way to achieve such a reduction in HCMV load. There are two important clinical settings where vaccination will have a significant impact on health outcome. The first is the prevention of the sequelae of congenital HCMV infection. A prophylactic vaccine to prevent congenital HCMV infection would make a major public health and economic contribution by reducing the incidence of birth defects.. The second setting is the prevention of HCMV-related complications in organ transplantation. HCMV is a major pathogen in both solid organ and bone marrow transplant recipients. We have identified a large number of cytotoxic T cell epitopes from a variety of HCMV antigens. A subset ...
Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on
Human cytomegalovirus (HCMV) infections are a major cause of morbidity and mortality among immunocompromised patients. Prolonged antiviral therapy is a cause of mutation and drug resistance in the HCMV genome.The aim of this study was to identify resistance to ganciclovir (GCV) in Iranian immunosuppressed patients at two different stages of the disease: early (before GCV is initiated) and late (after six months of GCV therapy).In this study, 87 specimens from Iranian patients were amplified using nested PCR amplification of the UL97 gene. Sequence analyses of products were performed for identifying the mutated codons.The present study show that the most frequent GCV-resistant mutations occurred in codons A594V (26.43%), H520Q (18.39%), and M460V (13.79%), consequently occurring at a low frequency in the L595S (2.29%), E596G (1.14%), and Del 594 (1.14%) codons, and with intermediate frequency in the C592G (10.34%), M460I (9.19%), and C603W (6.89%) codons. We describe for the first time a new GCV
In order to explore the potential of HLA-independent T cell therapy for human cytomegalovirus (HCMV) infections, we developed a chimeric antigen receptor (CAR) directed against the HCMV encoded glycoprotein B (gB), which is expressed at high levels on the surface of infected cells. T cells engineered with this anti-gB CAR recognized HCMV-infected cells and released cytokines and cytotoxic granules. Unexpectedly, and in contrast to analogous approaches for HIV, Hepatitis B or Hepatitis C virus, we found that HCMV-infected cells were resistant to killing by the CAR-modified T cells. In order to elucidate whether this phenomenon was restricted to the use of CARs, we extended our experiments to T cell receptor (TCR)-mediated recognition of infected cells. To this end we infected fibroblasts with HCMV-strains deficient in viral inhibitors of antigenic peptide presentation and targeted these HLA-class I expressing peptide-loaded infected cells with peptide-specific cytotoxic T cells (CTLs). Despite strong
TY - JOUR. T1 - Growth of human cytomegalovirus in primary macrophages. AU - Söderberg-Nauclér, Cecilia. AU - Fish, Kenneth N.. AU - Nelson, Jay. PY - 1998/9. Y1 - 1998/9. N2 - Human cytomegalovirus (HCMV) is a major human pathogen that causes considerable disease among immunocompromised individuals. A primary infection results in life-long persistence of the virus in a latent form. HCMV is known to be transferred by blood products, bone marrow, and solid organs, but the cell type that carries the latent infection has been difficult to identify. We have recently demonstrated reactivation of latent HCMV in allogeneically stimulated monocyte-derived macrophages (Allo-MDM). Reactivation occurred only in macrophages produced by allogeneic but not mitogenic stimulation. The presence of dendritic cell markers on some Allo-MDM cells suggested that these macrophages were related to dendritic cells. However, dendritic cells obtained by stimulation of monocytes with interleukin-4 (IL-4) and ...
5E5A: Crystal structure of the chromatin-tethering domain of Human cytomegalovirus IE1 protein bound to the nucleosome core particle
This study was initiated in order to define the relevance of ND10 domains for HCMV replication. Experimental results of previous studies suggested that ND10 domains may play a pivotal role for the initiation of HCMV IE gene expression. Arguments that could be interpreted in favor of such a proviral role of ND10 were as follows: (i) viral genomes were found to be deposited at the periphery of ND10 (29, 31); (ii) several regulatory proteins of HCMV at least transiently colocalize with PML and other ND10 components (2, 26, 32, 37); (iii) an immediate transcript environment consisting of viral IE transcripts, the IE2 protein, and SC35 domains was reported to form adjacent to ND10-localized HCMV genomes, suggesting that this spatial association is critical for the correct initiation of viral gene expression (31); (iv) only ND10-associated viral genomes were shown to develop into viral replication compartments (4, 48).. As an experimental approach to study the role of ND10 for HCMV replication, we ...
Human (Homo sapiens)micro-RNAs (hsa-miRNAs) regulate virus and host-gene translation, but the biological impact in patientswith human cytomegalovirus (hCMV) infection is notwell defined in a clinically relevantmodel. First, we compared hsa-miRNA expression profiles in peripheral blood mononuclear cells from 35 transplant recipients with and without CMV viremia by using a microarray chip covering 847hsa-miRNAs. This approach demonstrated a set of 142 differentially expressed hsamiRNAs. Next, we examined the effect of each of these miRNAs on viral growth by using human fibroblasts (human foreskin fibroblast-1) infected with the hCMV Towne strain, identifyinga subset of proviral andantiviral hsa-miRNAs. miRNA-target prediction software indicated potential binding sites within the hCMV genome (e.g., hCMV-UL52 and -UL100 [UL¼unique long]) and host-genes (e.g., interleukin-1 receptor, IRF1). Luciferaseexpressing plasmid constructs and immunoblotting confirmed several predicted miRNA targets. Finally, ...
Read Recombinant HCMV UL128 expression and functional identification of PBMC-attracting activity in vitro, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Gene expression during productive infection by the human cytomegalovirus (HCMV) occurs in an ordered and sequential manner, beginning with immediate early (IE), then early (E) and finally late (L) gene expression. Significant work has addressed the regulation of IE and E gene expression while relatively little work has addressed the control of late gene expression. In order to further address HCMV late gene expression, the promoter of the HCMV UL75 (glycoprotein H, gH) late gene was characterized. The data obtained in this study were combined with observations made in two other studies that have addressed HCMV late gene expression to develop a model of the regulation of HCMV late gene expression. The gH promoter and numerous promoter mutants were cloned into a reporter vector to address sequences responsible for the regulation of gene expression. These gH promoter constructs were transfected into human fibroblasts and subsequently infected with HCMV. Our data revealed that viral infection was necessary
Human cytomegalovirus (HCMV)-encoded G protein-coupled-receptor US28 is believed to participate in virus dissemination through modulation of cell migration and immune evasion. US28 binds different CC chemokines and the CX3C chemokine CX3CL1. Membrane-anchored CX3CL1 is expressed by immune-activated endothelial cells, causing redirection of CX3CR1-expressing leukocytes in the blood to sites of infection. Here, we used stable transfected cell lines to examine how US28 expression affects cell migration on immobilized full-length CX3CL1, to model how HCMV-infected leukocytes interact with inflamed endothelium. We observed that US28-expressing cells migrated more than CX3CR1-expressing cells when adhering to immobilized CX3CL1. US28-induced migration was G protein-signalling dependent and was blocked by the phospholipase Cβ inhibitor U73122 and the intracellular calcium chelator BAPTA-AM. In addition, migration was inhibited in a dose-dependent manner by competition from CCL2 and CCL5, whereas CCL3 ...
TY - JOUR. T1 - Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity. AU - Nguyen, Thi Hoang Oanh. AU - Mifsud, Nicole Andrea. AU - Stewart, Lisbeth A. AU - Rose, Mingus J. AU - Etto, Tamara L. AU - Williamson, Nicholas A. AU - Purcell, Anthony Wayne. AU - Kotsimbos, Tom C. AU - Schwarer, Anthony. PY - 2008. Y1 - 2008. UR - http://www.elsevier.com/locate/yprep. M3 - Article. VL - 61. SP - 22. EP - 30. JO - Protein Expression and Purification. JF - Protein Expression and Purification. SN - 1046-5928. IS - 1. ER - ...
The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced to express IE1 exhibit global repression of IL6- and oncostatin M-responsive STAT3 target genes. This repression is followed by STAT1 phosphorylation and activation of STAT1 target genes normally induced by IFNγ. The observed repression and subsequent activation are both mediated through the same region (amino acids 410 to 445) in the C-terminal domain of IE1, and this region serves as a binding site for STAT3. Depletion of STAT3 phenocopies the STAT1-dependent IFNγ-like response to IE1. In contrast, depletion of the IL6 receptor (IL6ST) or the STAT kinase JAK1 prevents this response. Accordingly, treatment with IL6 leads to prolonged STAT1 instead of STAT3 activation in wild-type IE1 expressing ...
T-0902611 benzenesulfonate is a cytomegalovirus replication inhibitor that may be useful in the treatment of cytomegalovirus infections.
McCartney, S. A., Brignole, E. J., Kolegraff, K. N., Loveland, A. N., Ussin, L. M., and Gibson, W. Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a. J. Biol. Chem.280:33206-33212 (2005) Loveland, A. N., Chan, C.-K., Brignole, E. J., and Gibson, W. Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J. Virol. 79:12961-12968 (2005) Wang, J., Loveland, A. N., Kattenhorn, L. M., Ploegh, H. L., and Gibson, W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: Mutant viruses altered in its active-site cysteine or histidine are viable. J. Virol. 80:6003-6012 (2006). Margulies, B. J. and Gibson, W. The chemokine receptor homologue encoded by UL27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles. ...
Human cytomegalovirus (CMV) is a ubiquitous DNA virus that causes severe disease in patients with immature or impaired immune systems. During active infection, CMV modulates host immunity, and CMV-infected patients often develop signs of immune dysfunction, such as immunosuppression and autoimmune phenomena. Furthermore, active viral infection has been observed in several autoimmune diseases, and case reports have linked primary CMV infection and the onset of autoimmune disorders. In addition, CMV infection promotes allograft rejection and graft-versus-host disease in solid organ and bone marrow transplant recipients, respectively, further implicating CMV in the genesis and maintenance of immunopathological phenomena. The mechanisms by which CMV could induce inhibition of host defense, inflammation, and autoimmunity are discussed, as is the treatment of virus-induced immunopathology with antivirals.
The pp28 (UL99) gene of human cytomegalovirus is expressed as a true late gene, in that DNA synthesis is absolutely required for mRNA expression. Our previous studies demonstrated that pp28 promoter sequences from position -40 to +106 are sufficient for late gene expression in the context of the viral genome (C. P. Kohler, J. A. Kerry, M. Carter, V. P. Muzithras, T. R. Jones, and R. M. Stenberg, J. Virol. 68:6589-6597, 1994). To extend these studies, we have examined the sequences in the downstream leader region of the pp28 gene for their role in late gene expression. Deletion of sequences from position -6 to +46 (deltaSS) results in a threefold increase in gene expression in transient assays. In contrast, deletion of sequences from position +46 to +88 (deltaA) has little effect on gene expression. These results indicate that the sequences from position -6 to +46 may repress gene expression. To further analyze this region, site-directed mutagenesis was performed. Mutation of residues from either ...
Human cytomegalovirus (CMV) remains a major cause of congenital disease in children as well as a significant opportunistic pathogen in immunocompromised individ...
Xenotransplantation using pig cells, tissues and organs may help to overcome the shortage of human tissues and organs for the treatment of tissue and organ failure. Progress in the prevention of immunological rejection using genetically modified pigs and new, more effective, immunosuppression regimens will allow clinical application of xenotransplantation in near future. However, xenotransplantation may be associated with the transmission of potentially zoonotic porcine microorganisms. Until now the only xenotransplantation-associated transmission was the transmission of the porcine cytomegalovirus (PCMV) into non-human primates. PCMV caused a significant reduction of the survival time of the pig transplant. Here the available publications were analysed in order to establish the mechanism how PCMV shortened the survival time of xenotransplants. PCMV is a herpesvirus related to the human cytomegalovirus and the human herpesviruses 6 and 7. These three human herpesviruses can cause serious disease among
Human cytomegalovirus (HCMV) was first isolated 50 years ago, when the new technology of cell culture became available. The pathogenesis of HCMV disease is complex, involving contributions from the host as well as from the virus. Increasing knowledge about the genetic composition of the virus can help to illuminate this complex series of relationships and provide a rational basis for therapeutic intervention and prevention of disease. The major immediate-early promoter (MIEP) enhancer contains multiple recognition sites for the transcription factors. Additionally, the MIEP is specifically transactivated by the tegument protein pp71, which is released as soon as incoming virions are uncoated. Thus, HCMV employs multiple methods independent of de novo viral gene expression to induce an intracellular milieu favorable to the initiation of immediate-early (IE) gene transcription. Humoral immunity could reduce the level of HCMV replication and reduce disease without being able to eliminate infection entirely.
TY - JOUR. T1 - Characterizing human cytomegalovirus reinfection in congenitally infected infants. T2 - An evolutionary perspective. AU - Pokalyuk, Cornelia. AU - Renzette, Nicholas. AU - Irwin, Kristen K.. AU - Pfeifer, Susanne. AU - Gibson, Laura. AU - Britt, William J.. AU - Yamamoto, Aparecida Y.. AU - Mussi-Pinhata, Marisa M.. AU - Kowalik, Timothy F.. AU - Jensen, Jeffrey. PY - 2017. Y1 - 2017. N2 - Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this notion is also highly relevant in our clinical understanding of viral infection, in which the novel habitat is a new host. Thus, quantifying the factors determining levels of variation is of considerable importance for the design of improved treatment strategies. Here, we focus on such a quantification of human cytomegalovirus (HCMV) - a ...
Table 1: Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation
Results:. Using a Cox proportional-hazards model, CMVIG was shown to reduce severe CMV-associated disease (multi-organ CMV disease, CMV pneumonia, or invasive fungal disease associated with CMV infection) from 26% to 12% (relative risk, 0.39; 95% CI, 0.17 to 0.89). When we controlled for the use of monoclonal antibodies to T cells (OKT3), CMVIG use was still protective (relative risk, 0.39; CI, 0.17 to 0.90). Rates of CMV disease were reduced from 31% to 19% (relative risk, 0.56; CI, 0.3 to 1.1) in CMVIG recipients although no effect on rates of CMV infection, graft survival, or patient survival at 1 year were shown. When we controlled for the urgency of transplantation and OKT3 use, a reduction in CMV disease (relative risk, 0.22; CI, 0.06 to 0.81) was shown for globulin recipients for all serologic groups except for the highest risk group (the CMV-seropositive donor, CMV-seronegative group). ...
Define cytomegalovirus: a herpesvirus (species Human herpesvirus 5 of the genus Cytomegalovirus) that in healthy… - cytomegalovirus in a sentence
The report on the global Cytomegalovirus Therapeutics market is collated by expert analysts, who have put down their experience in market researching skills to maximum use for the benefit of those wishing to invest in this market. The market for Cytomegalovirus Therapeutics is very competitive and in order to stay ahead of rivals, it is essential to know which region will be most lucrative to invest in as well as which application domain will emerge most promising within the global Cytomegalovirus Therapeutics market. The report aims for this, and does so, by making use of various charts, tables, graphs, and statistics, which helps in clearly presenting the data for novice readers. The report is useful not only to new entrants hoping to invest and make profits in the attractive Cytomegalovirus Therapeutics market but also for those well established players who have been in the field from many years. The report identifies the various challenges which need to be tackled to make progress in the ...
We assessed the value of the cytomegalovirus (CMV) antigenemia assay for diagnosing primary CMV infection in adults. The CMV antigenemia assay was performed for 40 patients admitted to our unit over a 2-year period with unexplained fever and suspected primary CMV infection. Nine of the 10 patients with primary CMV infection had positive CMV antigenemia assays, and the results were available within 5 hours. All 10 patients had a mononucleosis-like syndrome. All but one of the 30 other patients had negative CMV antigenemia assays. A false-positive result was obtained for a patient with systemic lupus erythematosus. Overall, the CMV antigenemia assay was 90% sensitive and 96% specific for the diagnosis of primary CMV infection. Therefore, the CMV antigenemia assay appears to be a simple, rapid, inexpensive test for the diagnosis of primary CMV infection in hospitalized adults.. ...
TY - JOUR. T1 - Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver transplantation. AU - Sia, Irene G.. AU - Wilson, Jennie A.. AU - Espy, Mark J.. AU - Paya, Carlos V.. AU - Smith, Thomas F.. PY - 2000/2/16. Y1 - 2000/2/16. N2 - Detection of cytomegalovirus (CMV) DNA in blood by PCR is a sensitive method for the detection of infection in patients posttransplantation. The test, however, has low specificity for the identification of overt CMV disease. Quantitative CMV PCR has been shown to overcome this shortcoming. The COBAS AMPLICOR CMV MONITOR test was evaluated by using consecutive serum and peripheral blood mononuclear cell (PBMN) samples from liver transplant patients. Twenty-five patients had CMV viremia (by shell vial cell culture assay) and/or tissue-invasive disease (by biopsy); 20 had no active infection. A total of 262 serum and 62 PBMN specimens were tested. Of 159 serum specimens from patients with overt CMV ...
Cytomegalovirus DNA was detected in 18 of 19 eyes with untreated cytomegalovirus retinitis. We detected cytomegalovirus DNA in 19 of 40 vitreous samples from patients with previously treated cytomegalovirus retinitis. Cytomegalovirus DNA was not detected in any of 69 patients who did not have a clinical diagnosis of cytomegalovirus retinitis. Thus, the assay had an estimated sensitivity of 95% in detecting untreated cytomegalovirus retinitis and a sensitivity of 48% in detecting cytomegalovirus retinitis that had been treated with systemic ganciclovir or foscarnet, or both. The assay did not give false-positive results in patients with vitreous hemorrhage or vitreous inflammation. Most important, the assay did not give false-positive results in AIDS patients with vitreous inflammation from causes other than cytomegalovirus retinitis.. ...
TY - JOUR. T1 - Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus. AU - DAquila, R. T.. AU - Summers, W. C.. PY - 1987. Y1 - 1987. N2 - Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.. AB - Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.. UR - ...
The neurodevelopmental state of 41 children with congenital cytomegalovirus infection and their controls was assessed at 2 years using the Griffiths scale. The scores achieved by children with congenital cytomegalovirus but with no associated neurological abnormality (asymptomatic) were similar to those of the control children, whereas the mean score of the five children with congenital infection and neurological impairment (symptomatic) was significantly lower. This study, which has the statistical power to detect differences in developmental quotient as small as five points, gave no evidence that at 2 years cytomegalovirus infection was associated with mental retardation in the absence of other neurological impairment. Thus 90% of children with congenital cytomegalovirus infection at 2 years are neurologically and developmentally normal.. ...
Human cytomegalovirus (CMV), a member of the human herpesviruses, is a deoxyribonucleic acid virus that is ubiquitous in the world. After primary infection, CMV develops a latent state; however, when the defense of the immune system decreases in a host, it can reactivate. Human cytomegalovirus infections are acquired via several ways. CMV is spread through contact with infected bodily fluids in humans, whereas it occurs in pregnant women through close contact with young children or through sexual transmission. The clinical manifestations consist of non-specific symptoms or clinical findings. However, the patients with acute CMV infections are generally asymptomatic. Congenital CMV infection (present at birth) occurs via intrauterine transmission of the virus that is thought to be transferred to the developing fetus. The common clinical manifestations of congenital CMV infection are sensorineural hearing loss, petechiae, jaundice at birth, and hepatosplenomegaly. The vast majority of healthy children and
Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness. Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those infected with AIDS. There are different types of retinitis, such as retinitis pigmentosa (causes tunnel vision).[medical citation needed] The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal detachment), presenting as: Blurred vision Blind spots Specks in your vision Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus retinitis. Other types of herpes viruses include herpes simplex viruses and Epstein-Barr virus. Once an individual is infected with these viruses they stay in the body for life. What triggers the virus to reactivate are the following (though CMV can also be congenital). Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or ...
The researchers found that anti-cytomegalovirus IgG and IgM were positive in 66% and 5% of patients respectively.. In addition, the research team found blood or urine cytomegalovirus replication markers in 6% of patients, all of whom had ulcerative colitis.. 3 patients had cytomegalovirus viremia and received anti-viral treatment with ganciclovir.. The researchers noted that only 1 of these patients had cytomegalovirus antigenemia and also associated biopsy-proven cytomegalovirus colitis, probably as a primary cytomegalovirus infection.. This patient is the only one who benefited from anti-viral therapy.. Prof Bouhnik concluded, Cytomegalovirus infection is infrequent in in-patients with active inflammatory bowel disease.. Systematic search of cytomegalovirus replication markers should not be performed.. Isolated viremia without associated antigenemia or direct demonstration of cytomegalovirus in ileocolonic biopsies does not warrant anti-viral therapy.. ...
Looking for cytomegalovirus infection? Find out information about cytomegalovirus infection. A common asymptomatic infection caused by cytomegalovirus, which can produce life-threatening illnesses in the immature fetus and in immunologically... Explanation of cytomegalovirus infection
TY - JOUR. T1 - Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood. AU - Della Chiesa, Mariella. AU - Falco, Michela. AU - Bertaina, Alice. AU - Muccio, Letizia. AU - Alicata, Claudia. AU - Frassoni, Francesco. AU - Locatelli, Franco. AU - Moretta, Lorenzo. AU - Moretta, Alessandro. PY - 2014/2/15. Y1 - 2014/2/15. N2 - NK cells are the first lymphoid population recovering after allogeneic hematopoietic stem cell transplantation and play a crucial role in early immunity after the graft. Recently, it has been shown that humanCMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical cord blood transplantation by accelerating the differentiation of mature NKG2A-killer Ig-like receptor (KIR)+ NK cells characterized by the expression of the NKG2C-activating receptor. In view of the hypothesis that NKG2C could be directly involved in NK cell ...
TY - JOUR. T1 - Cytomegalovirus infection presenting as an apple-core lesion of the colon. AU - Diaz-Gonzalez, V. M.. AU - Altemose, G. T.. AU - Ogorek, C.. AU - Palazzo, I.. AU - Pina, I. L.. PY - 1997. Y1 - 1997. N2 - Cytomegalovirus infection is highly prevalent among heart transplant recipients. Symptomatic cytomegalovirus infection can occur in all parts of the gastrointestinal tract. Colonic lesions are usually manifest as hemorrhagic colitis. This is a case of cytomegalovirus colitis presenting as a colonic stricture mimicking a colonic carcinoma. The initial presentation was that of both cellular and humoral rejection with fever, abdominal pain, and microcytic anemia with heme-positive stools. An abdominal computed tomogram was pertinent for a suspicion of carcinoma in the midtransverse colon. After resolution of the rejection episode, colonoscopy was performed, the result of which was abnormal for a short, high-grade stricture in the midtransverse colon. The patient underwent a right ...
We have developed an assay for measuring the susceptibilities of HCMV laboratory strains and clinical isolates to ganciclovir that uses flow cytometric analysis of fluorochrome-labeled HCMV-infected cells to determine the effect of ganciclovir on viral antigen synthesis. Infection at an MOI of 1 to 10 with the AD169 strain in the presence of inhibitory concentrations of ganciclovir reduced the percentage of cells synthesizing the late antigen without any effect on the percentage of cells synthesizing the immediate-early antigen. This result is consistent with the mode of action of ganciclovir, which inhibits viral DNA synthesis required for late-antigen synthesis (17). Ganciclovir had no effect on the synthesis of HCMV antigens in cells infected with D6/3/1, a ganciclovir-resistant derivative of AD169. The IC50 and IC90 for the ganciclovir-sensitive AD169 laboratory strain were 1.7 and 9.2 μM, respectively, and the IC50 for the ganciclovir-resistant D6/3/1 laboratory strain was greater than 12 ...
Background. Intrauterine transmission of cytomegalovirus (CMV) can occur whether a mother has prior immunity or acquires CMV for the first time during pregnancy. The degree of protection afforded an infected infant by the presence of antibody in the mother before conception is uncertain. Methods. We compared the outcomes of CMV-infected infants born to mothers who acquired primary CMV infection during pregnancy (primary-infection group) with those of CMV-infected infants born to mothers with immunity (recurrent-infection group). Screening for viruria identified 197 newborns with congenital CMV infection. Stored serum samples were used to categorize maternal infection as either primary or recurrent. We followed 125 infants from the primary-infection group and 64 from the recurrent-infection group. Serial medical, audiologic, psychometric, and eye examinations were used to identify sequelae of CMV infection. Results. Only infants in the primary-infection group had symptomatic CMV infection at ...
Description of disease Acute cytomegalovirus (CMV) infection. Treatment Acute cytomegalovirus (CMV) infection. Symptoms and causes Acute cytomegalovirus (CMV) infection Prophylaxis Acute cytomegalovirus (CMV) infection
Cytomegalovirus (CMV) is the most common congenital infection, with approximately 44,000 congenitally infected infants in the U.S. per year. A substantial proportion of these infants will die or suffer permanent injury as a result of their infection. The severity of congenital infection is greatest with primary maternal CMV infection. Currently, there is no proven method of preventing congenital CMV infection, and the approach to primary maternal CMV infection in the United States is haphazard and ineffective. One small, non-randomized study suggests that maternal administration of CMV hyperimmune globulin may significantly reduce the rate of congenital CMV infection following maternal primary infection. The MFMU CMV Trial will address the primary research question: does maternal administration of CMV hyperimmune globulin lower the rate of congenital CMV infection among the offspring of women who have been diagnosed with primary CMV infection during early pregnancy?. The research study is funded ...
Looking for cytomegalovirus mononucleosis? Find out information about cytomegalovirus mononucleosis. A self-limited illness such as infectious mononucleosis, the main manifestation of which is fever; it is the only cytomegalovirus illness clearly described... Explanation of cytomegalovirus mononucleosis
A new method for the quantitation of human cytomegalovirus (HCMV) DNA was used to determine the levels of viral DNA in parallel in 120 blood leukocyte (leukoDNAemia) and plasma (plasmaDNAemia) samples from 8 heart or heart-lung transplant patients and 17 AIDS patients with disseminated HCMV infection. PlasmaDNAemia was consistently associated with leukoDNAemia in both groups of patients. However, at least in the transplant patients, plasmaDNAemia was not necessarily associated with clinical symptoms, appearing later and disappearing earlier than leukoDNAemia during the course of infection. Quantitative mean levels of leukoDNAemia were mostly higher than those of plasmaDNAemia in both transplant and AIDS patients. However, in the absence of antiviral treatment, plasmaDNAemia levels were significantly higher in AIDS patients than in transplant recipients, whereas leukoDNAemia levels were not significantly different between the two groups of patients. A significant correlation was found between ...
BACKGROUND: Cytomegalovirus infection in renal transplant recipients is a major clinical problem, with both short and long term sequelae. Infection can occur as a result of reactivation of latent virus or new infection from donor tissues. The impact of donor and recipient serostatus on viremia is well recognised, with seronegative recipients at greatest risk after transplantation of an organ from a seropositive donor. However, the impact of grafting such organs into seropositive recipients is less clear. OBJECTIVES: To assess the impact of recipient serostatus on the risk of CMV antigenemia in a large renal transplant cohort. STUDY DESIGN: We prospectively quantified CMV antigenemia over time in a cohort of 486 recipients. We analysed the antigenemia status according to donor and recipient serostatus. RESULTS: Antigenemia was most common in seronegative recipients of organs from seropositive donors (D+/R-). Nevertheless, we observed that even in CMV seropositive recipients, the impact of donor
TY - JOUR. T1 - Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells. T2 - prognostic significance and biological impact. AU - Fornara, O. AU - Bartek, J. AU - Rahbar, A. AU - Odeberg, J. AU - Khan, Z. AU - Peredo, I. AU - Hamerlik, P. AU - Bartek, J. AU - Stragliotto, G. AU - Landázuri, N. AU - Söderberg-Nauclér, C. PY - 2016/2. Y1 - 2016/2. N2 - Glioblastoma (GBM) is associated with poor prognosis despite aggressive surgical resection, chemotherapy, and radiation therapy. Unfortunately, this standard therapy does not target glioma cancer stem cells (GCSCs), a subpopulation of GBM cells that can give rise to recurrent tumors. GBMs express human cytomegalovirus (HCMV) proteins, and previously we found that the level of expression of HCMV immediate-early (IE) protein in GBMs is a prognostic factor for poor patient survival. In this study, we investigated the relation between HCMV infection of GBM cells and the presence of GCSCs. Primary GBMs were ...
TY - JOUR. T1 - Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination. AU - Hamzeh, F. M.. AU - Lietman, P. S.. AU - Gibson, W.. AU - Hayward, G. S.. PY - 1990. Y1 - 1990. N2 - Infection with human cytomegalovirus in the presence of the antiviral nucleotide analog ganciclovir results in continuing low-level viral DNA synthesis and the accumulation of relatively small fragments of double-stranded progeny DNA. These fragments consistently proved to represent amplification of sequences from only one small section of the viral genome (EcoRI-V) lying near the center of the unique L segment. Further mapping revealed that the viral sequences represented in these fragments occurred in gradients of abundance that decreased in both directions from a point near .35 to 0.4 map unit. The proportion of amplified sequences increased with both time after infection and dosage of ganciclovir used. We conclude that the ...
Boomker JM, The TH, de Leij LF, and Harmsen MC. (2006). The human cytomegalovirus-encoded receptor US28 increases the activity of the major immediate-early promoter/enhancer. Virus Res 118: 196-200. PubMed. Boomker JM, Verschuuren EA, Brinker MG, de Leij LF, The TH, and Harmsen MC. (2006). Kinetics of US28 gene expression during active human cytomegalovirus infection in lung-transplant recipients. J Infect Dis 193: 1552-6. PubMed. Boomker JM, de Jong EK, de Leij LF, and Harmsen MC. (2006). Chemokine scavenging by the human cytomegalovirus chemokine decoy receptor US28 does not inhibit monocyte adherence to activated endothelium. Antiviral Res 69: 124-7. PubMed. Dankers PY, van Leeuwen EN, van Gemert GM, Spiering AJ, Harmsen MC, Brouwer LA, Janssen HM, Bosman AW, van Luyn MJ, and Meijer EW. (2006). Chemical and biological properties of supramolecular polymer systems based on oligocaprolactones. Biomaterials 27: 5490-501. PubMed. Gommans WM, van Eert SJ, McLaughlin PM, Harmsen MC, Yamamoto M, ...
Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or to prevent it re-activation in those who are already infected. As of 2014 no such a vaccine exists, although a number of vaccine candidates are under investigation. They include recombinant protein, live attenuated, DNA and other vaccines. As a member of the TORCH complex, cytomegalovirus can cause congenital infection, which can lead to neurological problems, vision and hearing loss. Infection/re-activation of CMV in immuno-compromised persons, including organ transplantation recipients, causes significant mortality and morbidity. Additionally, CMV has strong associations with plaques found in atherosclerosis progression. Because of all these, there has been considerable effort made towards the development of a vaccine, with particular emphasis on protection of pregnant women. Since vaccination of the immunocompromised persons introduces additional challenges, members of this population are less likely to be ...
The pUL97 protein kinase encoded by human cytomegalovirus is a multifunctional determinant of the efficiency of viral replication and phosphorylates viral as well as cellular substrate proteins. Here, we report that pUL97 is expressed in two isoforms with molecular masses of approximately 90 and 100 kDa. ORF UL97 comprises an unusual coding strategy in that five in-frame ATG start codons are contained within the N-terminal 157 aa. Site-directed mutagenesis, transient expression of point and deletion mutants and proteomic analyses accumulated evidence that the formation of the large and small isoforms result from alternative initiation of translation, with the start points being at amino acids 1 and 74, respectively. In vitro kinase assays demonstrated that catalytic activity, in terms of autophosphorylation and histone substrate phosphorylation, was indistinguishable for the two isoforms. An analysis of the intracellular distribution of pUL97 by confocal laser-scanning microscopy demonstrated that both
Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T ...
Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3 from NKp30 and, consequently, to reduced killing. Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor ...
Human cytomegalovirus (HCMV) infection is associated with cardiovascular disease (CVD) but the role of this virus in CVD progression remains unclear. We aimed to examine the HCMV serostatus in Russian patients (n = 90) who had undergone carotid endarterectomy (CEA) and controls (n = 82) as well as to determine the prevalence of HCMV immediate early (IE) and late (LA) antigens in carotid atherosclerotic plaques obtained from 89 patients. In addition, we sought to determine whether HCMV infection was associated with inflammatory activity in the plaque by quantifying infiltrating CD3 and CD68 positive cells and 5-LO immunoreactivity. HCMV serology was assessed with ELISA and immunohistochemistry staining was performed to detect HCMV antigens, CD3, CD68 and 5-LO reactivity. The Fishers exact test was used to compare i) seroprevalence of HCMV IgG between patients and controls and ii) HCMV-positive or -negative to that of CD3, CD68 and 5-LO immunoreactive cells in plaque samples. The student-t test was
May 13, 2019 · Cytomegalovirus, or CMV, is a common cause of disease in the transplant population. , high cytomegalovirus nucleic acid detection so there is a high seroprevalence. Because it is a member of the Herpesviridae family, , high cytomegalovirus nucleic acid detection molecular detection of CMV nucleic acid in clinical specimens (e.g., using real-time PCR) has become a common approach. In addition to qualitative detection of the , high cytomegalovirus nucleic acid ...
article{df027303-d823-4a01-840a-7bebb6a9e463, author = {Ivarsson, Sten A. and Ljung, Rolf}, issn = {0891-3668}, language = {eng}, number = {6}, pages = {436--437}, publisher = {Lippincott Williams & Wilkins}, series = {Pediatric Infectious Disease Journal}, title = {Neutropenia and congenital cytomegalovirus infection}, volume = {7}, year = {1988 ...
Abstract: The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and cellular factors for the reorganization of the nuclear envelope. To date, the mechanism of the association of human cytomegalovirus (HCMV) capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at nuclear lamina budding sites. Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an intranuclear NEC-capsid interaction. Staining patterns with phospho-specific lamin A/C ...
Abstract: The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and cellular factors for the reorganization of the nuclear envelope. To date, the mechanism of the association of human cytomegalovirus (HCMV) capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at nuclear lamina budding sites. Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an intranuclear NEC-capsid interaction. Staining patterns with phospho-specific lamin A/C ...
Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomegalovirus, can manipulate expression of these host proteins, with overstimulation of SOCS1 and/or SOCS3 putatively facilitating viral evasion of immune surveillance, and SOCS suppression generally exacerbating immunopathogenesis. This is particularly poignant within the eye, which contains a diverse assortment of specialized cell types working together in a tightly controlled microenvironment of immune privilege. When the immune privilege of the ocular compartment fails, inflammation causing severe immunopathogenesis and permanent, sight-threatening damage may occur, as in the case of AIDS-related human cytomegalovirus (HCMV) retinitis
Human being cytomegalovirus (HCMV) is a significant human being pathogen frequently connected with life-threatening disease in immunosuppressed individuals and newborns. contaminated cells. Quinazolines particularly inhibited viral early-late proteins synthesis but experienced no results at other phases from the replication routine, such as for example viral entry, in keeping with a blockage from the pUL97 function. As opposed to epithelial development element receptor inhibitors, quinazolines affected HCMV replication even though these were added hours after disease adsorption. Therefore, our results indicate that quinazolines are extremely effective inhibitors of HCMV replication in vitro by focusing on pUL97 proteins kinase activity. Human being cytomegalovirus (HCMV) is one of the family members and is connected with severe types of human being disease (23). Main acute infection aswell as lifelong prolonged infection from the sponsor ultimately causes multiple pathological effects which, ...
Prenatal serological diagnosis of intrauterine cytomegalovirus infection. Lange, I.; Rodeck, C.H.; Morgan-Capner, P.; Simmons, A.; Kangro, H.O. // British Medical Journal (Clinical Research Edition);6/5/1982, Vol. 284 Issue 6330, p1673 Examines the prenatal serological diagnosis of intrauterine cytomegalovirus infection in a rhesus-positive woman. Observation of a single fetus with gross ascites in an ultrasound scan; Findings of hypoalbuminemia on the fetal serum; Antibody titre during the initial serology for cytomegalovirus. ...
Viruses have numerous tricks for dodging the immune system. Stagg et al. reveal a key detail in one of these stratagems, identifying a protein that enables cytomegalovirus to shut down an antiviral defense.. Cytomegalovirus, which most people contract at some point in their lives, eludes immune system surveillance by targeting the protein MHC I. When were sick, MHC I captures bits of viral proteins and presents them to cytotoxic T cells, which respond by killing cells that harbor the virus, stanching the infection. However, two cytomegalovirus genes dupe cells into ubiquitinating MHC I and demolishing it in the proteasome, the cellular garbage disposal. To trigger MHC I ubiquitination, the genes co-opt a cellular protein called the E3 ligase. Researchers havent been able to pin down the identity of this protein, which could be one of several hundred enzymes.. Stagg et al. sifted 373 candidates by depleting them one by one with RNAi. Knocking down a ligase called TRC8 spared MHC I from ...
Objectives: To determine the rates of congenital and perinatal cytomegalovirus (CMV) infection among infants born to mothers infected with HIV compared with infants born to mothers not infected with HIV from a CMV-immune, low-income population.Study design: A total of 325 newborns from CMV-seropositive mothers were enrolled and evaluated for congenital CMV infection (150 infants from HIV+ mothers and 175 infants from HIV- mothers. A total of 101 infants from HIV+ mothers and 33 infants from HIV- mothers were evaluated for perinatal CMV infection. the virus was isolated from urine by culture in human fibroblasts and was detected by polymerase chain reaction at birth and at 15 days and 12 weeks of age.Results: Only 13 of 150 HIV+ mothers (8.7%) had an AIDS-defining condition, and none had a late-stage HIV infection. Congenital CMV infection was detected in 4 of 150 (2.7%) infants from HIV+ mothers and in 5 of 175 (2.9%) infants from HIV- mothers (p = 1.00). Perinatal CMV infection was diagnosed in ...
We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild viral illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer ...
Congenital cytomegalovirus (CMV) infection is a significant cause of infant morbidity and a high national priority for development of prevention and treatment strategies. CMV is the most common congenital infection, with incidence of approximately 0.7 percent of live births in the United States (30,000 or 1:150 infants/year). Nearly 20 percent exhibit permanent neurologic disabilities, including hearing loss and severe cognitive or physical impairment.
The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual regulatory cofactor of CDK9. This study provides evidence of direct interaction between pUL97 and cyclin T1 using yeast two-hybrid and co-immunoprecipitation analyses. Confocal immunofluorescence revealed partial colocalization of pUL97 with cyclin T1 in subnuclear compartments, most pronounced in viral replication centres. The distribution patterns of pUL97 and cyclin T1 were independent of HCMV strain and host cell type. The sequence domain of pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280. Additional co-immunoprecipitation analyses showed cyclin B1 and cyclin A as further pUL97 interaction partners. Investigation of the pUL97-cyclin T1 interaction in an ATP consumption assay
The best way to reduce the risk of CMV is to keep your CD4 count well above 100 cells/mm3. ART can strengthen your immune system and keep your CD4 count up. This is typically the best way to keep CMV under control.. People living with HIV whose CD4 counts are below 100 cells/mm3 should be examined regularly by an ophthamologist for retinitis even if they dont have symptoms. If you notice an increase of floaters (dark specks that seem to float around in your eye) or other changes in your vision, make an appointment to see your ophthamologist and have it checked out as soon as possible.. References. Walmsley SL, Raboud J, Angel JB, et al. Long-term follow-up of a cohort of HIV-infected patients who discontinued maintenance therapy for cytomegalovirus retinitis. HIV Clinical Trials. Jan-Feb 2006;7(1):1-9.. Lilleri D, Piccinini G, Baldanti F, et al. Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of ...
Congenital CMV infection results from transplacental transmission of the virus during maternal viremia. The fetus can be infected by either a newly acquired (primary) maternal infection or a recurrent (reactivated) maternal infection. The likelihood of fetal infection and the risk of associated damage and sequelae are higher after a primary infection. Maternal viremia is more likely to occur at primary than recurrent infection.1 After transplacental transmission, the virus spreads through the fetus by hematogenous route. Infection at an earlier gestational age often correlates with a worse outcome and may lead to intrauterine death.2. Cytomegalovirus is a DNA virus of the herpesvirus group which produces an enlargement of the infected cell, and microscopically with hematoxylin-eosin staining, a large 5-15μm sized violaceous to dark red intranuclear inclusion surrounded by a thin clear halo can be seen. At autopsy, diagnosis is most often made histologically by finding the characteristic CMV ...
Human Cytomegalovirus (HCMV) is a ubiquitous human pathogen that is associated with the development of numerous inflammatory diseases including vascular disease in solid allografts and certain forms of cancer. HCMV establishes life-long persistent/latent infections via nuanced manipulation of the host immune response. As such. HCMV encodes both chemokines and chemokine receptor homologs and is able to subvert the host chemokine-signaling network in infected cells and tissues. The pathological consequences of CMV chemokine mimicry are only beginning to be understood. In this dissertation, we investigate signaling from the HCMV-encoded chemokine receptor US28 in multiple HCMV susceptible cell types and identify a novel CMV-encoded chemokine. In Chapter 2, we demonstrate that US28 is a functionally selective chemokine receptor. Binding of CC-chemokines is pro-migratory when US28 is expressed in SMC and Fractalkine is an anti-migratory stimulus to SMC. Conversely, Fractaline stimulus is chemotactic to US28
Another name for Enteritis due to Cytomegalovirus is Cytomegalovirus Intestinal Infection. The evaluation of cytomegalovirus intestinal infection begins ...
The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and cellular factors for the reorganization of the nuclear envelope. To date, the mechanism of the association of human cytomegalovirus (HCMV) capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at nuclear lamina budding sites. Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an intranuclear NEC-capsid interaction. Staining patterns with phospho-specific lamin A/C antibodies are
The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic ...
Schleiss, M. R. (2008). "Cytomegalovirus vaccine development". Human Cytomegalovirus. Current Topics in Microbiology and ... Adenovirus vaccine COVID-19 vaccine (Part of today's pandemic since 2019) Coxsackie B virus vaccine Cytomegalovirus vaccine ...
Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Human Cytomegalovirus. Curr. Top. ... Sissons JG, Bain M, Wills MR (February 2002). "Latency and reactivation of human cytomegalovirus". J. Infect. 44 (2): 73-77. ... Sinclair J (March 2008). "Human cytomegalovirus: Latency and reactivation in the myeloid lineage". J. Clin. Virol. 41 (3): 180- ...
Cytomegalovirus (CMV) is a member of the betaherpesvirinae subfamily. CMV is responsible for a range of diseases, but mainly ... "Cytomegalovirus Infections: MedlinePlus". www.nlm.nih.gov. Retrieved 2015-05-13. Kaslow, Richard A.; Stanberry, Lawrence R.; ... Liu, X.; Wang, X.; Yan, S.; Zhang, Z.; Abecassis, M.; Hummel, M. (2013). "Epigenetic Control of Cytomegalovirus Latency and ...
"Cytomegalovirus (CMV) colitis". www.pathologyoutlines.com. Retrieved 2019-04-11. "Herpes Group (Cytomegalovirus, Herpes simplex ... and Cytomegalovirus. They are named after Edmund Cowdry. There are two types of intranuclear Cowdry bodies: Type A (as seen in ...
Cytomegalovirus (CMV) is a herpes related virus that can cause congenital defects. CMV has a high affinity for the developing ... Joseph LD, Kuruvilla S (2008). "Cytomegalovirus infection with lissencephaly". Indian Journal of Pathology & Microbiology. 51 ( ... Joseph LD, Pushpalatha, Kuruvilla S (2008). "Cytomegalovirus infection with lissencephaly". Indian Journal of Pathology & ...
"MXB inhibits murine cytomegalovirus". Virology. 522: 158-167. doi:10.1016/j.virol.2018.07.017. PMID 30032029. Staeheli P, ...
... cytomegalovirus; herpes simplex virus. Danger TORCH-complex that in primary infection during pregnancy may cause intrauterine ...
Cytomegalovirus infection Cytomegalovirus Dengue fever Dengue viruses (DEN-1, DEN-2, DEN-3 and DEN-4) - Flaviviruses ...
Sezgen E, An P, Winkler CA (23 July 2019). "Host Genetics of Cytomegalovirus Pathogenesis". Front Genet. 10: 616. doi:10.3389/ ...
Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. ... Fowler KB (December 2013). "Congenital cytomegalovirus infection: audiologic outcome". Clinical Infectious Diseases. 57 Suppl 4 ...
Its mechanism of action has been found to be similar in use against human cytomegalovirus. Lobucavir's bioavailability is 30-40 ... It reached phase III clinical trials for hepatitis B and herpesvirus, phase II clinical trials for cytomegalovirus, and ... Lobucavir has been shown to exhibit antiviral activity against herpesvirus, hepatitis B, HIV/AIDS, and human cytomegalovirus. ... Hoffman VF, Skiest DJ (February 2000). "Therapeutic developments in cytomegalovirus retinitis". Expert Opinion on ...
Valcyte (valganciclovir), for cytomegalovirus infection. Valium (diazepam), for anxiety disorders, alcohol withdrawal, status ... Cymevene (ganciclovir), for cytomegalovirus infection. Dalmane/Dalmadorm (flurazepam), for insomnia. Dilatrend (carvedilol), ...
Cytomegalovirus (the virus most frequently transmitted before birth). *dental caries. *Diabetes (Type 1) ...
Single case reports have implicated herpes simplex virus (HSV) and cytomegalovirus (CMV) but a study using PCR failed to ... 2003). "Herpes simplex virus, cytomegalovirus, and papillomavirus DNA are not found in patients with chronic pelvic pain ... Benson PJ, Smith CS; Smith (1992). "Cytomegalovirus prostatitis". Urology. 40 (2): 165-7. doi:10.1016/0090-4295(92)90520-7. ... "Acute cytomegalovirus prostatitis in AIDS". Genitourinary medicine. 72 (6): 447-8. doi:10.1136/sti.72.6.447. PMC 1195741 . PMID ...
... and cytomegalovirus. Boston exanthem disease Skin lesion James, William D.; Berger, Timothy G.; et al. (2006). Andrews' ... "Eruptive pseudoangiomatosis associated to cytomegalovirus infection". Eur J Dermatol. 17 (5): 455-6. doi:10.1684/ejd.2007.0257 ...
The recipient, however, died from cytomegalovirus. Following the introduction of cyclosporine, his unit went on to perform ...
"Cytomegalovirus Adult and Adolescent Opportunistic Infection". AIDSinfo. Retrieved 2020-04-25. "Vascular Endothelial Growth ... Since the 1990s, intravitreal antivirals have been used to treat cytomegalovirus retinitis (CMV retinitis) in immunodeficient ...
Iannetti P, Morellini M, Raucci U, Cappellacci S (1988). "HLA antigens, epilepsy and cytomegalovirus infection". Brain Dev. 10 ... Associations have been observed between A11 and familial otosclerosis, pulmonary tuberculosis, leprosy, and cytomegalovirus ...
Visser, LH; Van Der Meché, FG; Meulstee, J; Rothbarth, PP; Jacobs, BC; Schmitz, PI; Van Doorn, PA (1996). "Cytomegalovirus ... Powiązania przyczynowo-skutkowe?" [Cytomegalovirus infection in acute myocardial infarction. Is there a causative relationship ... Rider, JR; Ollier, WE; Lock, RJ; Brookes, ST; Pamphilon, DH (1997). "Human cytomegalovirus infection and systemic lupus ... Phillips, Anna C.; Carroll, Douglas; Khan, Naeem; Moss, Paul (2008). "Cytomegalovirus is associated with depression and anxiety ...
Sissons JG, Bain M, Wills MR (February 2002). "Latency and reactivation of human cytomegalovirus". The Journal of Infection. 44 ... Isomura H, Stinski MF (February 2013). "Coordination of late gene transcription of human cytomegalovirus with viral DNA ... Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Current Topics in Microbiology and ... Sinclair J (March 2008). "Human cytomegalovirus: Latency and reactivation in the myeloid lineage". Journal of Clinical Virology ...
Polymorphonuclear leukocyte function during cytomegalovirus mononucleosis. Clin Immunol Immunopath. 1979; 12:331-334. 44. ...
... cytomegalovirus, and Epstein-Barr virus. There are many more members that infect animals other than humans, some of which cause ... and human cytomegalovirus, which causes congenital herpes. The results indicated that CRISPR can be used to eliminate ... is researching to utilize cytomegalovirus vectors in the development of a therapeutic vaccine against herpes simplex virus 2 ( ... an antiviral medication used to treat and prevent cytomegaloviruses, converts it into the nucleoside analogue triphosphates. ...
Specific CD8+ T cells are generated in secondary lymphoid organs where naïve T cells encounter with cytomegalovirus antigen on ... The amount of memory cells generated as a response to cytomegalovirus is approximately 9.1% - 10.2% of all circulating CD4 + ... Kim, Jihye; Kim, A-Reum; Shin, Eui-Cheol (August 2015). "Cytomegalovirus Infection and Memory T Cell Inflation". Immune Network ... Shin, Eui-Cheol; Kim, A.-Reum; Kim, Jihye (2015-08-01). "Cytomegalovirus Infection and Memory T Cell Inflation". Immune Network ...
"Consensus on the role of human cytomegalovirus in glioblastoma". Neuro-Oncology. 14 (3): 246-55. doi:10.1093/neuonc/nor227. PMC ... Barami K (July 2010). "Oncomodulatory mechanisms of human cytomegalovirus in gliomas". Journal of Clinical Neuroscience. 17 (7 ... "Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ ... "Oncomodulation by human cytomegalovirus: novel clinical findings open new roads". Medical Microbiology and Immunology. 200 (1 ...
Cytomegalovirus is most commonly transmitted through kissing and sexual intercourse. It can also be transferred from an ... About 5% to 7% of cases of infectious mononucleosis is caused by human cytomegalovirus (CMV), another type of herpes virus. ... Approximately 90% of the human population has been infected with cytomegalovirus by the time they reach adulthood, but most are ... For those with weak immune systems, cytomegalovirus can cause more serious illnesses such as pneumonia and inflammations of the ...
Cook CH (2007). "Cytomegalovirus reactivation in "immunocompetent" patients: a call for scientific prophylaxis". The Journal of ... Cytomegalovirus (CMV) establishes latency in myeloid progenitor cells, and is reactivated by inflammation. Immunosuppression ... Dupont L, Reeves MB (2016). "Cytomegalovirus latency and reactivation: recent insights into an age old problem". Reviews in ... Sager K, Alam S, Bond A, Chinnappan L, Probert CS (2015). "Review article: cytomegalovirus and inflammatory bowel disease". ...
For human cytomegalovirus (HCMV), tetherin promotes entry of the virus, especially during cell differentiation. It has also ... "BST2/Tetherin enhances entry of human cytomegalovirus". PLOS Pathogens. 7 (11): e1002332. doi:10.1371/journal.ppat.1002332. PMC ...
Farrell, HE; Degli-Esposti, Davis-Poynter NJ (1999). "Cytomegalovirus evasion of natural killer cell responses". Immunology ...
Guiot, HM; Pita-García, IL; Bertrán-Pasarell, J; Alfonso, G (December 2006). "Cytomegalovirus polyradiculomyelopathy in AIDS: a ... "Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS". Neurology. 43 (3, Part 1): 493-9. doi:10.1212/WNL.43.3 ...
Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation.. Fielding CA1, Aicheler R1, ... Studies into human cytomegalovirus (HCMV) have aided both the identification and characterization of NKG2D ligands (NKG2DLs). ... This expansion must have be an ancient event as the whole family is conserved across simian cytomegaloviruses from old world ... Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation ...
... ,Reacts with an ... Anti-Cytomegalovirus (CMV) Immediate Early Antigen Monoclonal Antibody, Unconjugated, Clone 3G9.2 from CHEMICON. ...
Cytomegalovirus (CMV) is a virus found worldwide. Most people with CMV dont need treatment. Learn about who is at risk and how ... About CMV (Cytomegalovirus) (Centers for Disease Control and Prevention) * Cytomegalovirus (American Academy of Family ... Acute cytomegalovirus (CMV) infection (Medical Encyclopedia) Also in Spanish * CMV - gastroenteritis/colitis (Medical ... Cytomegalovirus (CMV) and Pregnancy (Organization of Teratology Information Specialists) - PDF Also in Spanish ...
Cytomegalovirus (CMV) is a very common virus of the Herpesviridae family. Most people are infected at some point during their ... Congenital cytomegalovirus infection (cCMV) occurs when the virus crosses the placenta during pregnancy and infects the fetus. ... Photograph source: Işikay S, Yilmaz K. Congenital cytomegalovirus infection and finger anomaly. Case Reports. 2013;2013: ...
Ho M. (1982) Characteristics of Cytomegalovirus. In: Cytomegalovirus. Current Topics in Infectious Disease. Springer, Boston, ...
A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach ... cytomegalovirus cytomegalovirus. cytomegalovirus sī˝təmĕg˝əlōvī´rəs [key], member of the herpesvirus family that can cause ... Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to ... A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. Most ...
1990). "Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169". Cytomegaloviruses. ... and simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus (RhCMV) that infect macaques; CCMV is known as both panine beta ... "cytomegalovirus". In 1990, the first draft of human cytomegalovirus genome was published, the biggest contiguous genome ... "Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection". Reviews in Medical ...
National Cytomegalovirus (CMV) Awareness Month is an annual observance held in June to increase awareness of CMV, the most ... National Cytomegalovirus (CMV) Awareness Month is an annual observance held in June to increase awareness of CMV, the most ... CDC takes this opportunity to increase awareness of congenital cytomegalovirus (CMV) among healthcare providers, pregnant women ...
Congenital cytomegalovirus is a condition that can occur when an infant is infected with a virus called cytomegalovirus (CMV) ... Congenital cytomegalovirus is a condition that can occur when an infant is infected with a virus called cytomegalovirus (CMV) ... Congenital cytomegalovirus occurs when an infected mother passes CMV to the fetus through the placenta. The mother may not have ... Cytomegalovirus (CMV). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennetts Principles and Practice of ...
What Is Cytomegalovirus?. Cytomegalovirus (CMV) is closely related to the viruses that cause chickenpox and mononucleosis (mono ... But cytomegalovirus (site-uh-meg-uh-low-VY-rus) can cause problems for an unborn child whose mother has the virus and for ...
Blurred vision Blind spots Specks in your vision Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus ... Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness ... The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal ... Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those ...
Cite this: Relevant Pericardial Effusion Caused by Cytomegalovirus Infection in An Immunocompetent Patient - Medscape - Jan 19 ... Journal Article Relevant Pericardial Effusion Caused by Cytomegalovirus Infection in An Immunocompetent Patient ... Relevant Pericardial Effusion Caused by Cytomegalovirus Infection in An Immunocompetent Patient. A Case Report. ... ALAT: Alanine aminotransferase; ASAT: Aspartate aminotransferase; CMV: Cytomegalovirus; CRP: C-reactive protein; EBV: Epstein- ...
Cytomegalovirus (CMV) is a virus that can cause an opportunistic infection (see Fact Sheet 500.) The virus is very common. ... Cytomegalovirus (CMV) is a virus that can cause an opportunistic infection (see Fact Sheet 500.) The virus is very common. ...
Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2, Epstein-Barr virus, ... encoded search term (Cytomegalovirus Colitis) and Cytomegalovirus Colitis What to Read Next on Medscape. Related Conditions and ... Clinical utility of cytomegalovirus antigenemia assay and blood cytomegalovirus DNA PCR for cytomegaloviral colitis patients ... Cytomegalovirus Colitis Medication. Updated: Feb 04, 2019 * Author: Douglas M Heuman, MD, FACP, FACG, AGAF; Chief Editor: BS ...
... cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection," Journal of Immunology, vol. 173, ... M. E. T. Penfold, D. J. Dairaghi, G. M. Duke et al., "Cytomegalovirus encodes a potent α chemokine," Proceedings of the ... Human cytomegalovirus (HCMV) represents a prototypic pathogenic member of the β-subgroup of the herpesvirus family. A range of ... C. S. Cobbs, "Cytomegalovirus and brain tumor: epidemiology, biology and therapeutic aspects," Current Opinion on Oncology, vol ...
Cytomegalovirus (CMV) neurologic disease is an uncommon serious complication of AIDS, which can cause paralysis or rapidly ... Cytomegalovirus encephalitis. Ann Intern Med 1996; 125:577.. *Morgello S, Cho ES, Nielsen S, et al. Cytomegalovirus ... Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial ... and Treatment of AIDS-related cytomegalovirus retinitis and AIDS-related cytomegalovirus gastrointestinal disease and ...
Cytomegalovirus (CMV) gastrointestinal disease is an uncommon but serious complication of AIDS. Prior to the availability of ... Approach to the diagnosis of cytomegalovirus infection. *Cytomegalovirus infection as a cause of pulmonary disease in HIV- ... and diagnosis of AIDS-related cytomegalovirus retinitis and Cytomegalovirus infection as a cause of pulmonary disease in HIV- ... AIDS-related cytomegalovirus gastrointestinal disease. Author. Mark A Jacobson, MD. Mark A Jacobson, MD ...
tr,A0A7T7DGL1,A0A7T7DGL1_9BETA Ba192 OS=Baboon cytomegalovirus OX=120505 PE=4 SV=1 ...
Vaccine prevention of maternal cytomegalovirus infection.. Pass RF1, Zhang C, Evans A, Simpson T, Andrews W, Huang ML, Corey L ... Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns. ...
Functional profiling of a human cytomegalovirus genome. Walter Dunn, Cassie Chou, Hong Li, Rong Hai, David Patterson, Viktor ... Functional profiling of a human cytomegalovirus genome. Walter Dunn, Cassie Chou, Hong Li, Rong Hai, David Patterson, Viktor ... Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus ... Functional profiling of a human cytomegalovirus genome. Walter Dunn, Cassie Chou, Hong Li, Rong Hai, David Patterson, Viktor ...
cytomegalovirus synonyms, cytomegalovirus pronunciation, cytomegalovirus translation, English dictionary definition of ... cytomegalovirus. n. Abbr. CMV Any of a group of herpesviruses that attack and enlarge epithelial cells. Such viruses also cause ... Related to cytomegalovirus: Cytomegalovirus infection, Epstein Barr virus. cy·to·meg·a·lo·vi·rus. (sī′tə-mĕg′ə-lō-vī′rəs). n. ... Signs and symptoms of cytomegalovirus disease in kidney transplant recipients.. A RARE PRESENTATION OF CYTOMEGALOVIRUS ...
Childcare and healthcare workers are among those at increased risk for exposure to cytomegalovirus (CMV). CMV is especially ... Childcare workers are at increased risk for exposure to cytomegalovirus (CMV). Childcare jobs may involve contact with children ...
Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection. Br Med J 1978; 1 :509 ... Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection.. Br Med J 1978; 1 doi: https://doi.org/10.1136/bmj.1.6111. ...
Cytomegalovirus Infections Clinical Research Trial Listings in Immunology Pediatrics/Neonatology Family Medicine Infections and ... Cytomegalovirus Infections Clinical Trials. A listing of Cytomegalovirus Infections medical research trials actively recruiting ... Third-Party Cytotoxic T-Lymphocytes (CTLs) for Cytomegalovirus (CMV) Infection The CTLs: CTLs are made at MD Anderson from ... Human cytomegalovirus (hCMV) is the most common opportunistic pathogen in the first months after solid organ transplantation. ...
Human cytomegalovirus (CMV) is 1 of 8 human herpesviruses. It is a member of the beta-herpesvirus subfamily, which also ... Epidemiology patterns of congenital cytomegalovirus infection. Approximately 10% of cases of congenital cytomegalovirus occur ... Pediatric Cytomegalovirus Infection. Updated: Apr 06, 2018 * Author: Mark R Schleiss, MD; Chief Editor: Russell W Steele, MD ... Cytomegalovirus and child day care. Evidence for an increased infection rate among day-care workers. N Engl J Med. 1989 Nov 9. ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Cytomegalovirus (CMV) IgM EIA. 3. Cytomegalovirus CMV IgG II. 4. Cytomegalovirus CMV CAP M. 5. Cytomegalovirus CMV IgM II. 6. ... Cytomegalovirus Antibody, IgG. 9. Cytomegalovirus Antibodies (Total). 10. Cytomegalovirus Antibody, IgM. 11. Cytomegalovirus by ... Cytomegalovirus (CMV) Antibody Test Kit - IgG. 7. Cytomegalovirus (CMV) Antibody Test Kit - IgM. 8. ...
African green monkey cytomegalovirus. › CeHV-5. › Cercopithecine betaherpesvirus 5. › Cercopithecine herpesvirus 5. ...
Inflammation of the retina of the eye caused by cytomegalovirus (CMV) infection. Symptoms, if any, include blurred vision, ... Inflammation of the retina of the eye caused by cytomegalovirus (CMV) infection. Symptoms, if any, include blurred vision, ...
This second edition updates the reader on the most common intrauterine transmitted viral infection, CMV. The history of this disease, its pathophysiological background, epidemiology and symptoms, as w
... cytomegalovirus) is a herpes virus. It is very common. It affects people of all ages and in all parts of the U.S. In most cases ... Cytomegalovirus (CMV) in Newborns. What is CMV in newborns?. CMV (cytomegalovirus) is a herpes virus. Its very common. It ...
  • Studies into human cytomegalovirus (HCMV) have aided both the identification and characterization of NKG2D ligands (NKG2DLs). (nih.gov)
  • The eight species in this genus include the type species, human betaherpesvirus 5 (HCMV, human cytomegalovirus, HHV-5), which is the species that infects humans. (wikipedia.org)
  • The most studied is human cytomegalovirus (HCMV), which is also known as human betaherpesvirus 5 (HHV-5). (wikipedia.org)
  • Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions, CMV infects around 40% of the population worldwide. (wikipedia.org)
  • Human cytomegalovirus (HCMV) represents a prototypic pathogenic member of the β -subgroup of the herpesvirus family. (hindawi.com)
  • A similar matter of recent debate is if and how infection with human cytomegalovirus (HCMV), another human herpes virus, could be linked with certain autoimmune diseases and how both conditions could interfere with each other. (hindawi.com)
  • Human cytomegalovirus (HCMV), a ubiquitous herpesvirus, causes a lifelong subclinical infection in healthy adults but leads to significant morbidity and mortality in neonates and immunocompromised individuals. (pnas.org)
  • Human cytomegalovirus (HCMV) is the leading viral cause of congenital abnormalities and mental retardation in newborns ( 1 ). (pnas.org)
  • Human cytomegalovirus (hCMV) is the most common opportunistic pathogen in the first months after solid organ transplantation. (centerwatch.com)
  • Cytomegalovirus (CMV) (from the Greek cyto- , "cell", and -megalo- , "large") is a viral genus of the Herpesviruses group: in humans it is commonly known as HCMV or Human Herpesvirus 5 (HHV-5). (bionity.com)
  • AiCuris reported results from a phase IIb trial of letermovir for the prevention of human cytomegalovirus (HCMV) following bone marrow transplantation. (centerwatch.com)
  • Human Cytomegalovirus (HCMV) is a ubiquitous infection that carries a severe teratogenic risk if primary infection is acquired during certain critical periods. (discovermagazine.com)
  • [ 3 ] Outros CMV atopáronse en varios mamíferos, pero as especies illadas deses animais son distintas en estrutura xenómica do HCMV e non causan infeccións en humanos. (wikipedia.org)
  • O Citomegalovirus humano ( Human cytomegalovirus ) ou HCMV, tamén chamado Herpesvirus 5 humano ( Human herpesvirus 5 ) ou HHV-5. (wikipedia.org)
  • [ 3 ] A infección por HCMV pasa xeralmente desapercibida en persoas con boa saúde, pero pode ser mortal en persoas inmunocomprometidas , como as persoas infectadas polo VIH , os receptores de transplante de órganos , [ 4 ] ou neonatos . (wikipedia.org)
  • Scientists have demonstrated that a human protein known as valosin containing protein (VCP) is essential for replication of human cytomegalovirus (HCMV). (eurekalert.org)
  • Human cytomegalovirus (HCMV) is a member of the herpesvirus family that generally remains unnoticed in the human body, but can be severely pathogenic in immunocompromised patients [1]. (kenyon.edu)
  • New findings reveal the surprisingly complex protein-coding capacity of the human cytomegalovirus, or HCMV, and provide the first steps toward understanding how the virus manipulates human cells during infection. (innovations-report.com)
  • Infection with human cytomegalovirus (HCMV) is a common and generally asymptomatic affection in childhood. (greenmedinfo.com)
  • The most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosphoprotein 65 (pp65), which is frequently included in CMV vaccines. (jci.org)
  • When the immune privilege of the ocular compartment fails, inflammation causing severe immunopathogenesis and permanent, sight-threatening damage may occur, as in the case of AIDS-related human cytomegalovirus (HCMV) retinitis. (frontiersin.org)
  • Herein we review how SOCS1 and SOCS3 impact the virologic, immunologic, and/or pathologic outcomes of herpesvirus infection with particular emphasis on retinitis caused by HCMV or its mouse model experimental counterpart, murine cytomegalovirus (MCMV). (frontiersin.org)
  • Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. (genome.jp)
  • But who has heard of Human Cytomegalovirus (HCMV)? (medicalxpress.com)
  • It is typically abbreviated as CMV: The species that infects humans is commonly known as human CMV (HCMV) or human herpesvirus-5 (HHV-5), and is the most studied of all cytomegaloviruses. (medicalxpress.com)
  • Congenital cytomegalovirus (CMV) infection is one of the most common viral causes of congenital infections in high resource countries and a leading cause of hearing loss as well as an important contributor to neurodevelopmental disabilities in children. (nih.gov)
  • A listing of Cytomegalovirus Infections medical research trials actively recruiting patient volunteers. (centerwatch.com)
  • Cytomegaloviruses are one of the leading causes of mental retardation in children and congenital viral infections. (openpr.com)
  • A cytomegalovirus can cause asymptomatic infections in immunocompromised individuals and can be transmitted to the fetus during pregnancy from his mother, which may exhibit primary or recurrent infection. (openpr.com)
  • We are interested in the role that viral anti-apoptotic genes may play in the pathogenesis of human cytomegalovirus (CMV) infections. (pnas.org)
  • Cytomegalovirus (CMV) infection of solid organ transplant (SOT) recipients causes both ''direct'' and ''indirect'' effects including allograft rejection, decreased graft and patient survival, and predisposition to opportunistic infections and malignancies. (wiley.com)
  • Toxoplasmosis, cytomegalovirus and rubella may cause congenital infections. (uwi.edu)
  • Boston, MA -- ( SBWIRE ) -- 04/21/2014 -- Global Markets Direct's, 'Cytomegalovirus (HHV-5) Infections - Pipeline Review, H1 2014', provides an overview of the Cytomegalovirus (HHV-5) Infections's therapeutic pipeline. (sbwire.com)
  • This report provides comprehensive information on the therapeutic development for Cytomegalovirus (HHV-5) Infections, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (sbwire.com)
  • It also reviews key players involved in the therapeutic development for Cytomegalovirus (HHV-5) Infections and special features on late-stage and discontinued projects. (sbwire.com)
  • Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness. (wikipedia.org)
  • The symptoms of cytomegalovirus retinitis have it usually starting in one eye (and also have the possibility of retinal detachment), presenting as: Blurred vision Blind spots Specks in your vision Cytomegalovirus (a type of herpes virus) is what causes cytomegalovirus retinitis. (wikipedia.org)
  • See 'Pathogenesis, clinical manifestations, and diagnosis of AIDS-related cytomegalovirus retinitis' and 'Treatment of AIDS-related cytomegalovirus retinitis' and 'AIDS-related cytomegalovirus gastrointestinal disease' and 'Cytomegalovirus infection as a cause of pulmonary disease in HIV-infected patients' . (uptodate.com)
  • The Center for Global Health Policy's " Science Speaks " blog describes "an agreement [.pdf] announced this week between the Medicines Patent Pool and Roche, the maker of the oral drug valganciclovir, which treats cytomegalovirus retinitis," an infection common among people living with HIV, particularly in Asian countries. (kff.org)
  • Cytomegalovirus retinitis usually results from reactivation of a latent CMV infection secondary to immunodeficiency and accounts for 90 percent of the infectious retinopathies in AIDS patients. (aao.org)
  • Which clinical history findings are characteristic of cytomegalovirus retinitis in HIV infection? (medscape.com)
  • Purpose To characterize the natural course and clinical predictors of cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected patients after initiation of highly active antiretroviral therapy (HAART). (lww.com)
  • To determine the therapeutic efficacy of a sustained-release intraocular drug delivery system for ganciclovir therapy of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). (clinicaltrials.gov)
  • Cytomegalovirus (CMV) is a very common virus of the Herpesviridae family. (cdc.gov)
  • Cytomegalovirus (CMV) (from the Greek cyto-, "cell," and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. (wikipedia.org)
  • Cytomegalovirus belongs to the herpesviridae family and is a double-stranded DNA virus. (openpr.com)
  • Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family acquired by late childhood in the majority of individuals. (genome.jp)
  • Cytomegalovirus (do grego cyto- , "célula", e -megalo- , "grande"), abreviado CMV, é un xénero viral da familia Herpesviridae ou herpesvirus. (wikipedia.org)
  • Cytomegalovirus (from the Greek cyto- , "cell", and -megalo- , "large") is a viral genus of the viral group known as Herpesviridae or herpesviruses. (medicalxpress.com)
  • EPIDEMIOLOGY: Worldwide - Cytomegalovirus (CMV) is a universally distributed pathogen with approximately 40-100% of the world's population having CMV antibody present in blood as evidence of infection(3,10-12), the highest prevalence being in countries in the developing world. (msdsonline.com)
  • Cytomegalovirus (CMV) antibody testing is recommended at age 1 year and then annually for CMV-seronegative, HIV-infected infants and children who are immunosuppressed (i.e. (nih.gov)
  • Cytogam® , Cytomegalovirus Immune Globulin Intravenous (Human) (CMV-IGIV), is an immunoglobulin G (IgG) containing a standardized amount of antibody to Cytomegalovirus (CMV). (rxlist.com)
  • The purified immunoglobulin is derived from pooled adult human plasma selected for high titers of antibody for Cytomegalovirus (CMV) (1). (rxlist.com)
  • cytomegalovirus sī˝təmĕg˝əlōvī´rəs [ key ] , member of the herpesvirus family that can cause serious complications in persons with weakened immune systems. (factmonster.com)
  • Cytomegalovirus, a member of the herpesvirus family, is related to the viruses that cause chickenpox and mononucleosis ("mono"), and is a common cause of viral infection . (akronchildrens.org)
  • The objectives were to determine the frequency of congenital cytomegalovirus infection among newborns who did not pass hearing screening tests or had confirmed hearing loss and to determine how often abnormal hearing screening results were the only manifestation of congenital cytomegalovirus infection. (aappublications.org)
  • Knowing the frequency of congenital cytomegalovirus (CMV) infection in newborn admitted to the Division of Neonatology, analysed by nested polymerase chain reaction (PCR) and DNA detection differences in blood and urine specimens. (uwi.edu)
  • Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection. (bmj.com)
  • Jeannet M , Stalder H . Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection. (bmj.com)
  • RESULTS: Blood samples of 295 community dwelling psycho-geriatric patients were tested for IgG antibodies to herpes simplex virus type 1 and 2, varicella zoster virus, Epstein Barr virus (EBV), cytomegalovirus (CMV), human herpes virus type 6 (HHV6), CP and HP. (mendeley.com)
  • Cytomegalovirus (CMV) infection is characterized by the development of such antibodies, which develop due to the infection of the virus that stays in an individual's body throughout his life. (openpr.com)
  • It contains the antibodies to help your body protect itself against infection with cytomegalovirus. (cigna.com)
  • The aim of this study is to investigate toxoplasmosis, cytomegalovirus and rubella IgG antibodies in women and children who were admitted to the Hatay Women and Children Hospital between January 1 and December 31, 2009. (uwi.edu)
  • A further two viruses found in the night monkey are tentatively placed in the genus Cytomegalovirus, and are called herpesvirus aotus 1 and herpesvirus aotus 3. (wikipedia.org)
  • As noted, cytomegalovirus (CMV) is a member of a family of 8 human herpesviruses, officially designated as human herpesvirus type 5 (HHV-5). (medscape.com)
  • Outros dous virus identificados no mono Aotus foron situados provisoriamente no xénero Cytomegalovirus , e denomínanse Herpesvirus aotus 1 e Herpesvirus aotus 3 . (wikipedia.org)
  • Pediatric infectious disease specialist Ravit Boger is adamant about attacking cytomegalovirus, or CMV, the most common congenital infection in this country, afflicting around 1 in 150 newborns. (hopkinsmedicine.org)
  • Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns. (nih.gov)
  • Public health agency The US Food and Drug Administration announced on Friday that it has approved the marketing of a new diagnostic test, the Alethia CMV Assay Test System, to aid in detecting the cytomegalovirus (CMV) herpes virus in newborns less than 21 days of age through the de novo premarket review pathway. (thefreedictionary.com)
  • Dried Blood Spot Real-time Polymerase Chain Reaction Assays to Screen Newborns for Congenital Cytomegalovirus Infection JAMA 2010 202(14) 1375-1382. (cdc.gov)
  • Retrospective chart review was performed for newborns who had abnormal hearing screening results and positive urine cytomegalovirus culture results at Parkland Memorial Hospital between September 1, 1999, and August 31, 2004. (aappublications.org)
  • Congenital cytomegalovirus infection was present for 6% of newborns with confirmed hearing impairment, and the majority of those infants were identified on the basis of abnormal newborn hearing screening results. (aappublications.org)
  • Identification of cytomegalovirus in newborns (congenital) by molecular biology methods polymerase chain reaction was more feasible using urine collection which is less invasive. (uwi.edu)
  • Human cytomegalovirus (CMV) is 1 of 8 human herpesviruses. (medscape.com)
  • https://www.merckmanuals.com/professional/infectious-diseases/herpesviruses/cytomegalovirus-cmv-infection. (mayoclinic.org)
  • Many viruses, including herpesviruses such as herpes simplex virus and cytomegalovirus, can manipulate expression of these host proteins, with overstimulation of SOCS1 and/or SOCS3 putatively facilitating viral evasion of immune surveillance, and SOCS suppression generally exacerbating immunopathogenesis. (frontiersin.org)
  • ViroPharma Incorporated publishes results of its previously described Phase 2 study showing that maribavir, when used as prophylaxis, reduced the rate of cytomegalovirus (CMV) reactivation and was well tolerated when compared to placebo in allogeneic stem cell, or bone marrow, transplant patients. (emaxhealth.com)
  • Merck & Co. released pivotal phase III study results of PREVYMIS (letermovir) for prophylaxis (prevention) of cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT). (centerwatch.com)
  • Cytomegalovirus Immune Globulin Intravenous (Human) is indicated for the prophylaxis of cytomegalovirus disease associated with transplantation of kidney , lung, liver , pancreas and heart . (rxlist.com)
  • Zinc may have a therapeutic role in the treatment of human cytomegalovirus infection. (greenmedinfo.com)
  • Human Cytomegalovirus infection is an important human disease," the authors further explain. (eurekalert.org)
  • Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells. (greenmedinfo.com)
  • Hookipa has successfully completed a Phase 1 trial of a VaxWave-based prophylactic vaccine to protect against cytomegalovirus infection and has started dosing patients in a Phase 2 trial in cytomegalovirus-negative patients awaiting kidney transplantation from cytomegalovirus-positive donors. (thefreedictionary.com)
  • Cytomegalovirus (CMV) infection is the most frequent opportunistic viral infection after kidney transplantation. (centerwatch.com)
  • An international team, led by Vince Emery, Senior Vice-President (Global Strategy and Engagement) and Professor of Translational Virology at the University of Surrey, have developed a model that will provide vital insight into how best to help patients with Cytomegalovirus (CMV) infection, particularly those who have undergone organ transplantation. (surrey.ac.uk)
  • Valaciclovir is used to prevent cytomegalovirus (CMV) infection and disease, following solid organ transplantation. (news-medical.net)
  • We are particularly interested in cytomegalovirus (CMV), which can cause serious problems in patients following transplantation. (clinicaltrials.gov)
  • Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to person by sexual contact, kissing, or the sharing of food. (factmonster.com)
  • This is a urine test for cytomegalovirus (CMV), a common virus that belongs to the herpes family. (rochester.edu)
  • Among participants aged 6-49 years in NHANES between 1999 and 2004 who had stored urine samples available and were cytomegalovirus (CMV) IgG positive, urine specimens were tested with real time PCR to detect CMV. (cdc.gov)
  • Among women with HIV who did not receive ART during pregnancy, those with evidence of cytomegalovirus, or CMV, in their urine at the time of labor and delivery were five times more likely to transmit HIV to their infants than women without CMV, according to recent findings. (healio.com)
  • Vaccine prevention of maternal cytomegalovirus infection. (nih.gov)
  • Use with cytomegalovirus immune globulin (intravenous-human) may either raise the chance of an infection or make the vaccine not work as well. (drugs.com)
  • An experimental vaccine against human cytomegalovirus (CMV) infection, which endangers the developing fetus, organ transplant recipients, patients with HIV and others who have a weakened immune system, proved safe and more effective than previous vaccines developed to prevent infection by the ubiquitous virus. (ucdavis.edu)
  • This expansion must have be an ancient event as the whole family is conserved across simian cytomegaloviruses from old world monkeys. (nih.gov)
  • Of those 16 infants, 12 (75%) were identified as having congenital cytomegalovirus infection only because of failure to pass newborn hearing screening tests. (aappublications.org)
  • Using hearing-targeted cytomegalovirus testing for infants failing newborn hearing screening can lead to earlier detection of hearing within 90 days, according to a study published in Pediatrics . (healio.com)
  • The name cytomegalovirus is derived from the associated enlargement of cells following infection. (msdsonline.com)
  • It is used to prevent cytomegalovirus (CMV) disease after organ transplant . (drugs.com)
  • The sequencing of CCMV, the chimpanzee cytomegalovirus, was obtained in 2002. (kenyon.edu)
  • Cytomegalovirus (CMV) neurologic disease is an uncommon serious complication of AIDS, which can cause paralysis or rapidly fatal encephalitis. (uptodate.com)
  • Latent cytomegalovirus infection exacerbates experimental colitis. (medscape.com)
  • A cytomegalovirus can cause asymptomatic contaminations in immunocompromised people and can be transmitted to the embryo while pregnancy from his mom, which may show essential or intermittent disease. (thefreedictionary.com)
  • Merck & Co. issued results of a phase III study of letermovir for the prevention of clinically significant cytomegalovirus (CMV) infection in adult (18 years and older) CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT), also known as bone marrow transplant (BMT). (centerwatch.com)
  • Chimerix reported results of a phase II trial CMX001-201 evaluating brincidofovir (CMX001) for the prevention of cytomegalovirus (CMV) infection in hematopoietic cell transplant (HCT) recipients. (centerwatch.com)
  • Cytomegalovirus colitis in intensive care unit patients: difficulties in clinical diagnosis. (medscape.com)
  • Overview of the diagnosis of cytomegalovirus infection. (genome.jp)
  • Cytomegalovirus (CMV) is a ubiquitous virus that can have a devastating effect on the fetus. (healio.com)
  • Cytomegalovirus is a common virus that can infect almost anyone. (chron.com)
  • CDC takes this opportunity to increase awareness of congenital cytomegalovirus (CMV) among healthcare providers, pregnant women, and parents. (cdc.gov)
  • A Chinese herbal formula containing Paris polyphylla, Dandelion, Woad, and Licorice appears safe and effective in reducing cytomegalovirus infection activity in pregnant women. (greenmedinfo.com)
  • CMV IG is used to help prevent infection by cytomegalovirus in people who receive an organ transplant (kidney, heart, liver, lung, or pancreas). (cigna.com)
  • Exposure to cytomegalovirus, herpes simplex virus type 2, or toxoplasma gondii was associated with cognitive deterioration in older individuals. (greenmedinfo.com)
  • The overall aim of this thesis was to study the immunologic effects of cytomegalovirus (CMV) and herpes simplex type 1 (HSV-1) infection in neurocognitive disorders. (diva-portal.org)
  • Long-term outcome of inflammatory bowel diseases with cytomegalovirus colitis: effect of antiviral treatment. (medscape.com)
  • Prevalence, detection rate and outcome of cytomegalovirus infection in ulcerative colitis patients requiring colonic resection. (medscape.com)
  • AIMS: To assess the prevalence of infection by cytomegalovirus in patients with intrahepatic cholestasis and extrahepatic cholestasis. (mendeley.com)
  • Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those with AIDS. (wikipedia.org)
  • The chance of blood clots may be raised with cytomegalovirus immune globulin (intravenous-human). (drugs.com)
  • If you have an allergy to cytomegalovirus immune globulin or any other part of cytomegalovirus immune globulin (intravenous-human). (drugs.com)
  • If you have had a skin reaction to cytomegalovirus immune globulin (intravenous-human) or another drug like it in the past. (drugs.com)
  • This is not a list of all drugs or health problems that interact with cytomegalovirus immune globulin (intravenous-human). (drugs.com)
  • You must check to make sure that it is safe for you to take cytomegalovirus immune globulin (intravenous-human) with all of your drugs and health problems. (drugs.com)
  • Tell all of your health care providers that you take cytomegalovirus immune globulin (intravenous-human). (drugs.com)
  • Very bad and sometimes deadly kidney problems have happened with cytomegalovirus immune globulin (intravenous-human). (drugs.com)
  • If you are 65 or older, use cytomegalovirus immune globulin (intravenous-human) with care. (drugs.com)
  • You will need to talk about the benefits and risks of using cytomegalovirus immune globulin (intravenous-human) while you are pregnant. (drugs.com)
  • Use cytomegalovirus immune globulin (intravenous-human) as ordered by your doctor. (drugs.com)
  • Cytogam® (cytomegalovirus immune globulin intravenous human) should be administered through an intravenous line using an administration set that contains an in-line filter (pore size 15µ) and a constant infusion pump (i.e. (rxlist.com)
  • Pre-dilution of Cytogam® (cytomegalovirus immune globulin intravenous human) before infusion is not recommended. (rxlist.com)
  • Cytogam® (cytomegalovirus immune globulin intravenous human) should be administered through a separate intravenous line. (rxlist.com)
  • If this is not possible, Cytogam® (cytomegalovirus immune globulin intravenous human) may be 'piggybacked' into a pre-existing line if that line contains either Sodium Chloride Injection, USP, or one of the following dextrose solutions (with or without NaCl added): 2.5% dextrose in water, 5% dextrose in water, 10% dextrose in water, 20% dextrose in water. (rxlist.com)
  • Several species of Cytomegalovirus have been identified and classified for different mammals. (wikipedia.org)
  • The genus consists of these 11 species: Aotine betaherpesvirus 1 Cebine betaherpesvirus 1 Cercopithecine betaherpesvirus 5 Human betaherpesvirus 5 Macacine betaherpesvirus 3 Macacine betaherpesvirus 8 Mandrilline betaherpesvirus 1 Panine betaherpesvirus 2 Papiine betaherpesvirus 3 Papiine betaherpesvirus 4 Saimiriine betaherpesvirus 4 Viruses in Cytomegalovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. (wikipedia.org)
  • As a species-specific disease, human cytomegalovirus can be found in all organs and bodily fluids, and therefore can lead to infection in developing infants (Figure 1). (kenyon.edu)
  • National Cytomegalovirus (CMV) Awareness Month is an annual observance held in June to increase awareness of CMV, the most common infectious cause of birth defects. (cdc.gov)
  • As the Zika virus continues to spread across the globe, and gain worldwide attention for its' potential birth defects, an NAU researcher is calling for greater public awareness of cytomegalovirus-the most common viral cause of birth defects in the United States. (news-medical.net)
  • Lin Y-T, Prendergast J, Grey F (2017) The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication. (eurekalert.org)
  • Cite this: Relevant Pericardial Effusion Caused by Cytomegalovirus Infection in An Immunocompetent Patient - Medscape - Jan 19, 2018. (medscape.com)
  • Each of these groups were then divided into two subgroups: subgroup A - positive serology (IgM) for cytomegalovirus and subgroup B - negative serology (IgM) for cytomegalovirus. (mendeley.com)
  • RESULTS: The frequency of positive serology (IgM) for cytomegalovirus was 29.4% in children with intrahepatic cholestasis and 28.5% in children with extrahepatic cholestasis. (mendeley.com)
  • The history of maternal infection was more common in extrahepatic cholestasis patients with positive serology for cytomegalovirus. (mendeley.com)
  • this genus contains mouse cytomegalovirus (MCMV) is also known as murid betaherpesvirus 1 (MuHV-1) and the closely related Murid betaherpesvirus 2 (MuHV-2) that is found in rats. (wikipedia.org)
  • Wiesbaden, Germany Abbott ( NYSE: ABT ) announced it has received CE Mark in the European Union to market its RealTime PCR (polymerase chain reaction) molecular diagnostic test for cytomegalovirus (CMV) DNA quantitation in human plasma or whole blood. (webwire.com)
  • A pilot trial of a novel cytomegalovirus immune globulin in renal transplant recipients. (rxlist.com)
  • Cytomegalovirus infection was identified in 24 (5%) of 483 tested infants and 16 (6%) of the 256 infants with subsequently confirmed hearing impairment. (aappublications.org)
  • Congenital cytomegalovirus - or CMV - affects approximately one in 200 infants. (healio.com)
  • Infants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. (medicalxpress.com)
  • Cytomegalovirus infection in patients with new onset ulcerative colitis: a prospective study. (medscape.com)
  • Clinical utility of cytomegalovirus antigenemia assay and blood cytomegalovirus DNA PCR for cytomegaloviral colitis patients with moderate to severe ulcerative colitis. (medscape.com)
  • Antiviral therapy in steroid-refractory ulcerative colitis with cytomegalovirus: systematic review and meta-analysis. (medscape.com)
  • Cytomegalovirus (CMV) is a virus that can cause an opportunistic infection (see Fact Sheet 500 . (thebody.com)
  • Cytomegalovirus (CMV) is a virus found around the world. (medlineplus.gov)
  • Congenital cytomegalovirus infection (cCMV) occurs when the virus crosses the placenta during pregnancy and infects the fetus. (cdc.gov)
  • A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. (factmonster.com)
  • Congenital cytomegalovirus is a condition that can occur when an infant is infected with a virus called cytomegalovirus (CMV) before birth. (medlineplus.gov)
  • But cytomegalovirus (site-uh-meg-uh-low-VY-rus) can cause problems for an unborn child whose mother has the virus and for people with weakened immune systems . (kidshealth.org)
  • Cytomegalovirus (CMV) is a common virus. (thebody.com)
  • Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. (uptodate.com)
  • However, the sites of cytomegalovirus (CMV) latency have been difficult to define experimentally in humans, even though epidemiologic evidence indicates that undetectable virus can be transferred from donor to recipient in transfused blood or a transplanted organ. (nih.gov)
  • The participation of the cytomegalovirus in the etiopathogenesis of neonatal hepatitis has been already known for some time, but only recently there have been indications that this virus may be one of the possible etiological factors for extrahepatic biliary atresia. (mendeley.com)
  • Each year, about 40,000 children are born infected with human cytomegalovirus, or CMV, and about 8,000 of these children suffer permanent disabilities due to the virus - almost one an hour. (medindia.net)
  • Cytomegalovirus (sy-tuh-meg-uh-lo-VY-rus), or CMV, is a very common virus. (akronchildrens.org)
  • A case note was kept on each patient with the following data: age of patient at admission, serologic result for cytomegalovirus, history of maternal infection, prematurity, fetal distress, birth weight, ponderal gain, choluria and fecal acholia. (mendeley.com)