Cytogenetics
Cytogenetic Analysis
Chromosome Aberrations
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute
Translocation, Genetic
Myelodysplastic Syndromes
Chromosome Banding
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Leukemia, Myeloid
Chromosome Disorders
Chromosome Painting
A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.
Interphase
Monosomy
Aneuploidy
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Prognosis
Karyotype
Remission Induction
fms-Like Tyrosine Kinase 3
Chromosomes, Human
Leukemia, Myelomonocytic, Acute
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 8
Metaphase
Neoplasms, Adipose Tissue
Chromosomes, Human, Pair 13
Chromosome Inversion
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 15
Gene Rearrangement
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Chromosomes, Human, Pair 7
Anemia, Refractory, with Excess of Blasts
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Immunophenotyping
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Disease-Free Survival
Chromosomes, Human, Pair 17
Spectral Karyotyping
Chromosomes, Human, Pair 16
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasm, Residual
DNA Probes
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
Treatment Outcome
Chromosomes, Human, Pair 21
Tandem Repeat Sequences
Survival Rate
Oncogene Proteins, Fusion
Chromosomes, Human, Pair 1
Philadelphia Chromosome
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Chromosomes, Human, Pair 3
Daunorubicin
Laurence-Moon Syndrome
An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Orthoptera
Chromosome Breakage
Chromosomes, Human, Pair 2
Digoxigenin
Transplantation, Homologous
Antineoplastic Combined Chemotherapy Protocols
Isochromosomes
Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Idarubicin
Blast Crisis
Leukemia, Promyelocytic, Acute
Prenatal Diagnosis
Chromosomes
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 12
Mutation
Chromosomes, Human, Pair 20
Life Tables
Chromosomes, Human, X
Y Chromosome
Chromosomes, Human, Pair 22
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Leukemia, Myelomonocytic, Chronic
Gene Duplication
Comparative Genomic Hybridization
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Transplantation, Autologous
Chromosomes, Human, Pair 4
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Sex Chromosome Aberrations
Gene Expression Regulation, Leukemic
Thalidomide
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Chromosomes, Artificial, Bacterial
Myeloid-Lymphoid Leukemia Protein
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Genetic Markers
Bone Marrow Transplantation
Chromosome Mapping
Intellectual Disability
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Turner Syndrome
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
Core Binding Factor Alpha 2 Subunit
Chromosomes, Human, Pair 10
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Multivariate Analysis
Mosaicism
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Genetic Techniques
Bone Marrow Cells
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Gene Deletion
Cytodiagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin Heavy Chains
Fusion Proteins, bcr-abl
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Transplantation Conditioning
Paraffin Embedding
Oligonucleotide Array Sequence Analysis
Chromosomes, Human, Pair 19
X Chromosome
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Nuclear Proteins
DNA Copy Number Variations
Combined Modality Therapy
Chromosomal Instability
Leukocyte Count
Anemia, Aplastic
False Negative Reactions
DNA, Satellite
Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Chromosomes, Plant
Vidarabine
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Antigens, CD34
Follow-Up Studies
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Polyploidy
Sensitivity and Specificity
Busulfan
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Gene Expression Profiling
Hematologic Neoplasms
Phenotype
Evaluation Studies as Topic
Lymphoma, B-Cell
Gene Amplification
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Prospective Studies
Centromere
Azacitidine
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Salvage Therapy
Gene Dosage
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Down Syndrome
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Proto-Oncogene Proteins
In Situ Hybridization
Hodgkin Disease
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
How identical would cloned children be? An understanding essential to the ethical debate. (1/486)
The ban on human cloning in many countries worldwide is founded on an assumption that cloned children will be identical to each other and to their nuclear donor. This paper explores the scientific basis for this assumption, considering both the principles and practice of cloning in animals and comparing genetic and epigenetic variation in potential human clones with that in monozygotic twins. (+info)Immunocytogenetic detection of normal and abnormal oocytes in human fetal ovarian tissue in culture. (2/486)
This study aimed to: (i) determine whether oocytes are present in cultures of human fetal ovary; (ii) identify whether meiotic anomalies are evident; and (iii) assess whether preparation or culture conditions influence oocyte survival and meiotic progression. Ovaries were collected from fetuses after termination at 13-16 weeks. Oocyte assessment utilized antibodies specific for synaptonemal complex proteins (associated with chromosomes only during meiosis), and antibodies to centromeric proteins. Fragments of tissue were cultured in minimal essential medium + 10% serum +/- follicle stimulating hormone (100 mIU/ml). The sera were fetal calf serum (FCS), FCS for embryonic stem cells (ES-FCS) and human female serum. The numbers and stages of oocytes were assessed after 7-40 days, and particular arrangements of chromosome synapsis identified. Results in fresh tissue included oocytes at leptotene, zygotene, pachytene and diplotene in three of five samples. Four specimens remained viable in vitro, and three had detectable oocytes after culture. The numbers of oocytes and the proportions of zygotene and pachytene cells increased with time in culture. The proportion of degenerate cells in culture was initially higher than in fresh samples, but declined subsequently. More oocytes were detected in ES-FCS and human serum than in FCS. We conclude that human oocytes survive in culture and that progression through prophase I continues. (+info)Danish National In-Vitro Fertilization Registry 1994 and 1995: a controlled study of births, malformations and cytogenetic findings. (3/486)
This paper reports data from the Danish in-vitro fertilization (IVF) registry from 1994 to 1995 including data on treatments and the results of these (perinatal outcome, cytogenetic findings and fetal malformations) in comparison with a control group matched for maternal age, parity, multiplicity and year of birth. There were 1756 deliveries of 2245 children (24.3% twins, 1.8% triplets). The rate of prematurity among IVF children was 23.8% (NS) [singletons 7. 3% (P < 0.05), twins 41.2% and triplets 93.5%], 23.6% weighed <2500 g [singletons 7% (P < 0.05), twins 42.2% and triplets 87.1%]. The perinatal mortality rate was 21.8 in the study group compared to 17. 4 in the control group (NS). In total, 13.2% of all clinical pregnancies and 15.4% of the pregnancies that resulted in a delivery had a prenatal genetic examination. Of all examined, 3.5% had an abnormal karyotype. In total, 107 (4.8%) children in the study group and 103 (4.6%) in the control group were born with malformations (NS), compared to 2.8% in the background population. Our results indicate that it is the characteristics of the patients and multiplicity of pregnancy, rather than the assisted reproductive technology that determines the fetal risks of IVF pregnancies compared to the background population. (+info)AlphaIFN-induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5). (4/486)
Chronic eosinophilic leukemia (CEL) is a myeloproliferative disease characterized by excessive eosinophilic proliferation with clonal cytogenetic abnormalities. The most frequent cytogenetic abnormality is a break in the q 31-35 region of chromosome 5, where genes encoding for IL-3, IL-5 and GM-CSF (all cytokines involved in eosinophilopoiesis) are located. We report the case of a patient with CEL with t(1;5) (q23;q31), who obtained complete hematologic and major cytogenetic response after two years of alpha-interferon (alpha-IFN) therapy. Two other cases of complete response to alpha-IFN are reported in the literature. A trial with alpha-IFN could be considered as front line treatment in this rare disease. (+info)CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. (5/486)
OBJECT: We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma. METHODS: These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis. MATERIALS: Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated. RESULTS: The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. All had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CD5 and CD8. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CD5, CD10 and CD13 in patient 1, CD5 in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jdelta1 induced by T-cell specific enhancer. Rearrangement of TCR beta and gamma genes occurred in patient 2, and IgH and TCR beta underwent rearrangement in patient 3. CONCLUSION: Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage. (+info)A survey of 1,000 cases referred for cytogenetic study to King Khalid University Hospital, Saudi Arabia. (6/486)
We reviewed cytogenetic studies that have been done in 1,000 consecutive non-oncology samples that were referred to the Cytogenetics Unit at King Khalid University Hospital, Riyadh, Saudi Arabia. The cases were grouped according to the referral diagnosis and the requested cytogenetic service. The frequency of the different types of numerical and structural abnormalities was determined and the relative frequency of cases with abnormal karyotype was calculated in each group. This study should assist physicians in Saudi Arabia and surrounding countries by increasing the awareness of the frequency of cytogenetic abnormality in different diagnostic groups. It also gives figures for comparison with other countries and research centers. (+info)Biodosimetry results obtained by various cytogenetic methods and electron spin resonance spectrometry among inhabitants of a radionuclide contaminated area around the siberian chemical plant (Tomsk-7). (7/486)
On April 6, 1993, near the town of Tomsk (Russia) there was an accident at the Siberian Chemical Plant (SCP) which resulted in extensive contamination of an area of 250 km(2) to the north of SCP with long-lived radionuclides such as (239)Pu, (137)Cs and (90)Sr. Cytogenetic methods and electron spin resonance (ESR) spectrometry of tooth enamel were used to estimate the radiation doses received by the population. The ESR signal intensity and the chromosomal aberration frequency in lymphocytes of the tooth donors showed a good correlation. The data showed that 15% of the inhabitants of the Samus settlement received a radiation dose >90 cGy. The exceptions were results of an examination of fishermen, where ESR gave high values (80-210 cGy) but both the chromosome assay and the cytokinesis block micronucleus method gave lower ones (8-52 cGy). A large increase in chromosome damage was observed in people born between 1961 and 1969. It was found that during these years several serious accidents at the Siberian Chemical Plant had occurred causing radiation pollution of the area. The number of cells with chromosome aberrations was significantly less among the people arriving in Samus after 1980. We found good correlations between the level of carotene consumption and a decrease in frequency of both micronuclei in binucleated lymphocytes (r = 0.68, P < 0.01) and chromatid aberrations (r = 0.61, P < 0.01) among the inhabitants. We also examined the inhabitants of Samus for opisthorchis infection, which was present in 30% of the population. The Samus inhabitants affected by Opisthorchis felineus showed significantly increased levels of micronuclei in binucleated lymphocytes and chromatid aberrations as compared with the controls. (+info)Processing of DNA damage induced by hydrogen peroxide and methyl methanesulfonate in human lymphocytes: analysis by alkaline single cell gel electrophoresis and cytogenetic methods. (8/486)
The persistence of induced DNA damage in human lymphocytes after mitogen stimulation and its relationship to subsequent cytogenetic alterations were investigated. The analysis of single-strand breaks and alkali-labile sites by single cell gel electrophoresis (SCGE) showed the almost complete repair of damage induced in resting lymphocytes by methyl methanesulfonate (MMS, 140-210 microM) and hydrogen peroxide (H(2)O(2), 25-100 microM) during the first 16 h of culture. On the other hand, DNA damage was shown to persist to a large extent when cells were cultured in the presence of the repair inhibitor cytosine beta-D-arabinofuranoside (Ara-C) (1 microg/ml). Although highly effective in the induction of DNA lesions detectable by SCGE, both agents failed to significantly increase the rate of micronucleus formation in cytokinesis-blocked cells harvested 66 h after treatment. However, when Ara-C was present during the first 16 h of culture, micronuclei were significantly increased at all doses. Conversely, sister chromatid exchange (SCE) rates were increased by chemical treatments to a higher extent in cultures without Ara-C. Delayed treatments, 16 h after mitogen stimulation, led to a significant induction of micronuclei in the case of MMS but not with H2O(2). These results suggest that only a minor fraction of DNA damage induced in resting lymphocytes is available for fixation through misreplication, because of its effective repair prior to S phase. However, the processing of damage through recombination pathways can lead to increased SCE rates in treated cells. These features of the processing of DNA damage in human lymphocytes should be taken into account when structural cytogenetic alterations in cultured lymphocytes are used in monitoring human exposure to genotoxic agents. (+info)
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Clinical relevance of cytogenetics to pediatric practice. Postnatal findings of Patau syndrome - Review of 5 cases | Nina Minha...
Cytogenetics of Chilean angiosperms: Advances and prospects
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Cytogenetics
Cytogenetic Directory Cytogenetics Resources Human Cytogenetics - Chromosomes and Karyotypes Association for Genetic ... markets and companies Cytogenetics-methods-and-trouble-shooting Department of Cytogenetics of Wikiversity (CS1 maint: uses ... Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy ... Cytotaxonomy Karyotype Molecular cytogenetics Ploidy Virtual karyotype Rieger, R.; Michaelis, A.; Green, M.M. (1968), A ...
Molecular Cytogenetics
... is a continuous, open access, peer-reviewed journal covering research into cytogenetics and its ... "Molecular Cytogenetics". 2015 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2016. Official ... Cytogenetics, Genetics journals, English-language journals, All stub articles, Genetics journal stubs). ...
Comparative Cytogenetics
... is a peer-reviewed open access scientific journal covering plant and animal cytogenetics, ... "Comparative Cytogenetics: International Journal of Plant and Animal Cytogenetics, Karyosystematics, and Molecular Systematics ... "Comparative Cytogenetics". 2013 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2014. Wikimedia ... Commons has media related to Media from Comparative Cytogenetics. Official website (Articles with short description, Short ...
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Starting first from cytogenetics in the nineteens, the Atlas now combines different types of knowledge in a single web site: ... The Atlas of Genetics and Cytogenetics in Oncology and Haematology, created in 1997 by Jean-Loup Huret (with bioinformatics by ... "Atlas of Genetics and Cytogenetics in Oncology and Haematology". hdl:2042/15655. {{cite journal}}: Cite journal requires , ... The Atlas is accessed by: 1- researchers in cytogenetics, molecular biology, cell biology; 2- clinicians, haematologists, ...
Marmoset
Cytogenetics. 10 (6): 384-393. doi:10.1159/000129828. PMID 14267132. Primate Info Net Callithrix Factsheets Common Marmoset ...
Orinoco crocodile
Cohen, M. M.; Gans, C. (1970). "The chromosomes of the order Crocodilia". Cytogenetics. 9 (2): 81-105. doi:10.1159/000130080. ...
Lalji Singh
Singh received the INSA Medal for Young Scientists in 1974, for his research work in the field of cytogenetics. In 1971-72, ... During his early science career as a Masters student in 1968, Singh became interested in studying the cytogenetics of Indian ... in the area of cytogenetics under the guidance of professor S.P. Ray Chaudhuri. A summary of the findings from his doctoral ... Cytogenetics. 7 (3): 161-168. doi:10.1159/000129980. PMID 5693182. Singh, L.; Purdom, I.F.; Jones, K.W. (1980). "Sex Chromosome ...
Sequential hermaphroditism
J. R. Gold (1979). "Cytogenetics". In W. S. Hoar; D.J. Randall; J. R. Brett (eds.). Bioenergetics and Growth. Fish Physiology. ...
Chimera (genetics)
Cytogenetics. 10 (6): 384-393. doi:10.1159/000129828. PMID 14267132. Starr, Barry (November 30, 2004). "Understanding Genetics ...
Freemartin
Cytogenetics. 6 (3): 276-85. doi:10.1159/000129948. PMID 6035567. Bruere AN, Fielden ED, Hutchings H (March 1968). "XX-XY ...
Calico cat
Cytogenetics. 6 (3-4): 228-241. doi:10.1159/000129944. PMID 6035565. Retrieved 22 June 2020. Todd, Neil B. (November 1977) Cats ...
Genome diversity and karyotype evolution of mammals
"Paris Conference (1971): Standardization in human cytogenetics". Cytogenetics. 11 (5): 317-362. 1972. doi:10.1159/000130202. ... In comparative cytogenetics, chromosome homology between species was proposed on the basis of similarities in banding patterns ... Therefore, in comparative cytogenetics, phylogenetic relationships should be determined on the basis of the polarity of ... Technical advances have marked the various developmental steps of cytogenetics. The first step of the Human Genome Project took ...
Tetrasomy X
Cytogenetics. 7 (4): 249-259. doi:10.1159/000129989. PMID 5722744. Polani PE (16 August 1969). "Abnormal sex chromosomes and ...
Andrzej Tarkowski
Cytogenetics 5, 394-400. Tarkowski, A.K. and Wroblewska, J. (1967) Development of blastomeres of mouse eggs isolated at the 4- ... Cytogenetics). This publication is often cited, although has been publicised over 50 years ago. In later years professor ...
Fluorescence in situ hybridization
Molecular Cytogenetics. 15 (1): 44. doi:10.1186/s13039-022-00622-0. PMC 9547437. PMID 36207754. Pernthaler A, Pernthaler J, ... the technique used for labelling Molecular cytogenetics Virtual karyotype Another schematic of FISH process. Microfluidic chip ... Cytogenetics, Laboratory techniques, Molecular biology, Gene tests, Pathology, Nuclear organization). ...
Northern mole vole
Comparative Cytogenetics. 4 (1): 55-66. doi:10.3897/compcytogen.v4i1.25. ISSN 1993-078X. Moshkin MP, Novikov EA, Petrovski DV ( ...
Pallister-Killian syndrome
Molecular Cytogenetics. 11: 45. doi:10.1186/s13039-018-0395-z. PMC 6098576. PMID 30140312. Arghir A, Popescu R, Resmerita I, ... Molecular Cytogenetics. 12: 39. doi:10.1186/s13039-019-0449-x. PMC 6717365. PMID 31497069. Salzano E, Raible SE, Kaur M, ...
Camel
Koulischer, L; Tijskens, J; Mortelmans, J (1971). "Mammalian cytogenetics. IV. The chromosomes of two male Camelidae: Camelus ...
Arrhenotoky
Gavrilov, I.A.; Kuznetsova, V.G. (2007). "On some terms used in the cytogenetics and reproductive biology of scale insects ( ... Homoptera: Coccinea)" (PDF). Comparative Cytogenetics. 1 (2): 169-174. ISSN 1993-078X. Pearcy, M.; Aron, S.; Doums, C.; Keller ...
Dolichoderinae
Comparative Cytogenetics. 6 (2): 107-14. doi:10.3897/CompCytogen.v6i2.2397. PMC 3833797. PMID 24260655. Fisher, Brian L. and ... Comparative Cytogenetics. 6 (2): 107-14. doi:10.3897/CompCytogen.v6i2.2397. PMC 3833797. PMID 24260655. Please check the source ...
Hydrophilidae
Comparative Cytogenetics. 14 (1): 1-10. doi:10.3897/CompCytogen.v14i1.47656. ISSN 1993-078X. PMC 6971125. PMID 31988701. "Life ...
Small supernumerary marker chromosome
Atkin NB (May 1997). "Cytogenetics of carcinoma of the cervix uteri: a review". Cancer Genetics and Cytogenetics. 95 (1): 33-9 ... Molecular Cytogenetics. 11: 29. doi:10.1186/s13039-018-0377-1. PMC 5941596. PMID 29760779. Bawazeer S, Alshalan M, Alkhaldi A, ... Cytogenetics and Cell Genetics. 91 (1-4): 44-6. doi:10.1159/000056816. PMID 11173828. S2CID 11893833. Panani AD, Roussos C ( ... Cancer Genetics and Cytogenetics. 131 (1): 13-8. doi:10.1016/s0165-4608(01)00516-7. PMID 11734312. "YEATS4 YEATS domain ...
Isodisomy
Molecular Cytogenetics. 8 (1): 85. doi:10.1186/s13039-015-0190-z. ISSN 1755-8166. PMC 4632482. PMID 26539248. Leveno, p. 51. ...
Pentasomy X
Molecular Cytogenetics. 2 (20): 20. doi:10.1186/1755-8166-2-20. PMC 2766382. PMID 19811657. Stoicanescu DL, Cevei ML, Gug CR, ...
Ring chromosome 15
Molecular Cytogenetics. 11 (1): 19. doi:10.1186/s13039-018-0367-3. ISSN 1755-8166. PMC 5828142. PMID 29492108. JACOBSEN, PETREA ...
Calisto herophile
Comparative Cytogenetics. 5 (3): 191-210. doi:10.3897/compcytogen.v5i3.1730. PMC 3833777. PMID 24260629. Wikispecies has ...
Myzus persicae
plants". Comparative Cytogenetics. 8 (4): 259-274. doi:10.3897/CompCytogen.v8i4.8568. ISSN 1993-078X. PMC 4296714. PMID ...
Henry Heng
"Molecular Cytogenetics welcomes new co-Editor-in-Chief". 12 June 2012. Henry H.Q. Heng (2006-05-10). "Stochastic cancer ... He formerly served as co-editor-in-chief of the journal Molecular Cytogenetics. Heng proposed a two-phased model of cancer ... Molecular Cytogenetics. 11: 31. doi:10.1186/s13039-018-0376-2. PMC 5946397. PMID 29760781. Richard A. Stein (2020-06-23). " ...
Muriel Davisson
Cytogenetics. In: Mouse in Biomedical Research, 2nd edition, Volume 1, Fox J, Barthold S. Davisson MT, Newcomer C, Quimby F, ...
Browsing by Subject "Cytogenetics"
Cytogenetics of vectors of disease of man : report of a WHO scientific group [meeting held in Geneva from 31 October to 6 ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (Organización Mundial de la ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (Organisation mondiale de la ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (World Health ...
Cytogenetics : USDA ARS
ARS Home » Southeast Area » Stuttgart, Arkansas » Dale Bumpers National Rice Research Center » Docs » Cytogenetics ... Cytogenetics is a branch of genetics that is concerned with the study of the structure and function of the cell, especially the ... chromosomes. Rice cytogenetics is used to identify differences in the DNA or chromosomes by examining the chromosomes found in ...
Browsing by Subject "Cytogenetics"
Cytogenetics of vectors of disease of man : report of a WHO scientific group [meeting held in Geneva from 31 October to 6 ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (Organización Mundial de la ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (Organisation mondiale de la ... WHO Scientific Group on the Cytogenetics of Vectors of Disease of Man; World Health Organization (World Health ...
Genetics 101: cytogenetics and FISH | CMAJ
Cytogenetics Gallery
Molecular Cytogenetics Market worth 2.52 Billion USD by 2021
The molecular cytogenetics market is projected to reach USD 2.52 Billion by 2021 from USD 1.55 Billion in 2016, at a CAGR of ... Browse 78 market data tables and 47 figures spread through 147 pages and in-depth TOC on Molecular Cytogenetics Market by ... Based on regions, the global molecular cytogenetics market is segmented into North America, Europe, Asia, and the Rest of the ... The genetic disorders segment is expected to account for the largest share of the global molecular cytogenetics market in 2016. ...
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Cytogenetics. - OpenAGRICOLA
Comparative Cytogenetics of the Black Ghost Knifefish (Gymnotiformes: Apteronotidae): Evidence of Chromosomal Fusion and...
UW Cytogenetics | Wisconsin State Laboratory of Hygiene
Molecular Cytogenetics in Onion Breeding.
Molecular Cytogenetics in Onion Breeding.. Ludmila Khrustaleva*1,2, Natalia Kudryavtseva1,2, Majd Mardini1, Aleksey Ermolaev1, ... Molecular cytogenetics provides a toolbox of methods for DNA sequence visualization on nucleus or chromosomes bridging the gap ... Application of Molecular Cytogenetics in Interspecific Plant Breeding. Genomic In Situ Hybridization (GISH) has a huge ... An ultra-sensitive method termed tyramide-FISH (tyr-FISH) was adapted for plant cytogenetics [2]. We used tyr-FISH to ...
New market leader for clinical cytogenetics laboratory services - European Pharmaceutical Review
Sure Laboratories is an independent clinical cytogenetics service laboratory providing dedicated microarray-based comparative ... Sure Laboratories is an independent clinical cytogenetics service laboratory providing dedicated microarray-based comparative ... Sure Laboratories is an independent clinical cytogenetics service laboratory providing dedicated microarray-based comparative ...
Molecular Cytogenetics Market Boosting the Growth Worldwide: 2020 Market Key Dynamics, Recent and Future Demand, Trends, Share...
... research report exhibits all the important information identified with the specific product for the Molecular Cytogenetics... ... According to the pharmaceutical market industry research into Global Molecular Cytogenetics market, worldwide industry analysis ... This Molecular Cytogenetics report gives top to bottom outline of the global Molecular Cytogenetics market ... Global Molecular Cytogenetics market gives you an enormous scale platform loaded with brilliant opportunities to the specific ...
Advanced Centre for Treatment Research & Education in Cancer | Cancer Cytogenetics
However, EQAS Cytogenetics service is not readily available in India. Considering the need for EQAS Cytogenetics in India, the ... Cancer Cytogenetics. Officer in charge : Dr. Dhanlaxmi Shetty. Overview. Cancer Cytogenetics Department comprises of service ... EQAS Cytogenetics is a biannual (2 cycles) program starting from 1st January to 31st December. Institute/Participants have to ... Department of Cancer Cytogenetics. Room No. 6, Ground floor, CCE Building. ACTREC, Tata Memorial Centre. Navi Mumbai - 410 210 ...
Chromosomes came first: first years of human chromosomes. The beginnings of human cytogenetics - Zurich Open Repository and...
Growth Control And Cytogenetics Of Malignant Gliomas | [email protected]
Genomic profiling of myeloma: the best approach, a comparison of cytogenetics, FISH and array-CGH of 112 myeloma cases |...
Results Clonal abnormalities were identified in 30% of cases by cytogenetics and 97% by FISH and array CGH. By combining array ... Methods 112 myeloma cases were analysed by whole bone marrow cytogenetics and by FISH and array CGH performed on purified ... Genomic profiling of myeloma: the best approach, a comparison of cytogenetics, FISH and array-CGH of 112 myeloma cases ... Genomic profiling of myeloma: the best approach, a comparison of cytogenetics, FISH and array-CGH of 112 myeloma cases ...
Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic...
MDR1(+) secondary AML patients with unfavorable cytogenetics had a CR rate of only 12%. Thus, AML in the elderly is associated ... MDR1(+) secondary AML patients with unfavorable cytogenetics had a CR rate of only 12%. Thus, AML in the elderly is associated ... MDR1(+) secondary AML patients with unfavorable cytogenetics had a CR rate of only 12%. Thus, AML in the elderly is associated ... MDR1(+) secondary AML patients with unfavorable cytogenetics had a CR rate of only 12%. Thus, AML in the elderly is associated ...
Molecular Biology - Molecular Biology Cytogenetics - ALL Testing
Cytogenetics | Biology Discussion
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Molecular Cytogenetics | Articles
Cytogenetics
Revistas científicas em Ciências da Saúde com informação sobre a descrição bibliográfica dos títulos, o acesso ao formato eletrônico e as coleções em formato impresso localizadas nas bibliotecas que cooperam com o Catálogo Coletivo SeCS, da rede BIREME Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
Subject: Cytogenetics
Revistas científicas em Ciências da Saúde com informação sobre a descrição bibliográfica dos títulos, o acesso ao formato eletrônico e as coleções em formato impresso localizadas nas bibliotecas que cooperam com o Catálogo Coletivo SeCS, da rede BIREME Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
Subject: Cytogenetics
Revistas científicas em Ciências da Saúde com informação sobre a descrição bibliográfica dos títulos, o acesso ao formato eletrônico e as coleções em formato impresso localizadas nas bibliotecas que cooperam com o Catálogo Coletivo SeCS, da rede BIREME Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
Mantle Cell Lymphoma: Practice Essentials, Overview, Pathophysiology
Cytogenetics. Most cases of MCL are associated with a chromosome translocation between chromosome 11 and 14, t(11;14)(q13;q32). ... Fluorescence in situ hybridization (FISH) or cytogenetics for detection of t(11;14), t(14;18), CLL panel. ... What is the role of cytogenetics in the workup of mantle cell lymphoma (MCL)? ...
Usage of the cyto-genetics and cytology to identify the action mechanisms of two bio-fertilizers on Allium cepa meristematic...
Ali, R.T., Abdel-Ghany, E.M., Mohamed, F.I. et al. Usage of the cyto-genetics and cytology to identify the action mechanisms of ... Usage of the cyto-genetics and cytology to identify the action mechanisms of two bio-fertilizers on Allium cepa meristematic ... Usage of the cyto-genetics and cytology to identify the action mechanisms of two bio-fertilizers on Allium cepa meristematic ... One hundred percent of yeast extract is prepared in the cytology and cytogenetics lab, NRC, Egypt, after Hanafy et al.s (2012 ...
IMSEAR at SEARO: Cytogenetics in retinoblastomas.
Latest Cytogenetics of Pediatric Acute Myeloid Leukemia - Hematology Advisor
Researchers updated the latest information about cytogenetics in pediatric patients with AML with a focus on de novo disease. ... Cytogenetics and molecular subtypes of pediatric AML also vary by age. Infants tend to have fewer favorable cytogenetics ... Cytogenetics affect diagnosis and prognosis in pediatric acute myeloid leukemia (AML), a rare type of cancer in children. ... Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge. Genes (Basel). 2021;12(6):924. doi:10.3390 ...
Molecular cytogenetics of lymphoma: where do we stand in 2010?<...
Kluin, P., & Schuuring, E. (2011). Molecular cytogenetics of lymphoma: where do we stand in 2010? Histopathology, 58(1), 128- ... Molecular cytogenetics of lymphoma : where do we stand in 2010?. In: Histopathology. 2011 ; Vol. 58, Nr. 1. blz. 128-144. ... Kluin, P & Schuuring, E 2011, Molecular cytogenetics of lymphoma: where do we stand in 2010?, Histopathology, vol. 58, nr. 1 ... Molecular cytogenetics of lymphoma: where do we stand in 2010?. Philip Kluin*, Ed Schuuring ...
GeneticsLaboratoryGlobal molecular cytogenetics market2021LaboratoriesHigh-risk cytogeneticsChromosomesFluorescence in situ hybriGeneticKaryotypeClinicalFavorableMethodsDiagnosisComparativeSpecialtiesAbnormalitiesPerspectivesFISHCancer2002MandatoryNovoBotanyAssessmentReviewSignificantlyServiceTechniquesResearchDiseasePatientsAnalysisYears
Genetics4
- Cytogenetics is a branch of genetics that is concerned with the study of the structure and function of the cell, especially the chromosomes. (usda.gov)
- The Cytogenetics Laboratory operates under the medical direction of Dr. Kathleen Bone, PhD, who is board certified in Clinical Cytogenetics by the American Board of Medical Genetics and Genomics (ABMGG). (wisconsindiagnostic.com)
- Both proof-of-concept studies have been published in the American Journal of Human Genetics:"Next generation cytogenetics: comprehensive assessment of 52 hematological malignancy genomes by optical genome mapping" - https://pubmed.ncbi.nlm.nih.gov/34237281/ . (x-omics.nl)
- Most recently, she worked with the Nationwide Children's Cytogenetics and Molecular Genetics Laboratory as an associate director and with the Ohio State University Medical Center Department of Pathology as an associate clinical professor. (tiddfuneralhomes.com)
Laboratory8
- The Department of Cancer Cytogenetics, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the first ever Cancer Cytogenetics laboratory established in Tata Memorial Hospital in 1988. (actrec.gov.in)
- The Cancer Cytogenetics Department at ACTREC is a well equipped laboratory that provides comprehensive diagnostic testing [Conventional Karyotyping (CK) and Fluorescence In-situ hybridization (FISH) studies] for all hematolymphoid malignancies both in-house by and referrals. (actrec.gov.in)
- She placed a CG(ASCP) certified Cytogenetics Technologist with laboratory company Nashville, Tennessee. (ka-recruiting.com)
- Medical laboratory scientists also work in the areas of biotechnology, toxicology, and various specialties such as cytogenetics and transplantation. (bgsu.edu)
- The adaptation of IV-Cell by Northwell Health will streamline its cytogenetics laboratory to achieve rapid, more accurate results in blood-related cancer testing. (accesswire.com)
- Northwell Health intends to use IV-Cell for all relevant cytogenetics cases within their entire laboratory system, benefiting patients with leukemia, myelodysplasia, myeloproliferative disorders and other hematologic malignancies. (accesswire.com)
- IV-Cell includes all necessary components required to conduct the cell culturing including fetal bovine serum and all necessary mitogens in pre-mixed format, ready to use by the cytogenetics laboratory without the need for any reconstitution or preparation. (accesswire.com)
- Following a post-doctoral fellowship in clinical cytogenetics at Cincinnati Children's Hospital Research Foundation, Ruthann ran the CHMCC cytogenetics laboratory for several years, eventually transitioning to Dayton Children's Hospital where she practiced both genetic counseling and laboratory diagnostics. (tiddfuneralhomes.com)
Global molecular cytogenetics market4
- The genetic disorders segment is expected to account for the largest share of the global molecular cytogenetics market in 2016. (marketsandmarkets.com)
- Based on regions, the global molecular cytogenetics market is segmented into North America, Europe, Asia, and the Rest of the World (RoW). (marketsandmarkets.com)
- According to the pharmaceutical market industry research into Global Molecular Cytogenetics market, worldwide industry analysis, trend, size, share, development in the database. (pharmiweb.com)
- Global Molecular Cytogenetics market gives you an enormous scale platform loaded with brilliant opportunities to the specific business, makers, firms, association enterprises and merchants that are continuously taking a shot at their business development at a world level. (pharmiweb.com)
20211
- The molecular cytogenetics market is projected to reach USD 2.52 Billion by 2021 from USD 1.55 Billion in 2016, at a CAGR of 10.1% from 2016 to 2021. (marketsandmarkets.com)
Laboratories3
- Based on end users, the molecular cytogenetics market is segmented into clinical and research laboratories, academic research institutes, pharmaceutical and biotechnology companies, and others. (marketsandmarkets.com)
- IV-Cell is a proprietary cell culture medium, sold on an RUO basis and developed at Precipio, which enables cancer cytogenetics laboratories to culture multiple cell lineages simultaneously, thereby increasing the likelihood of selecting the correct cell lineage for cytogenetic analysis. (accesswire.com)
- BioMediGen Diagnostic Centers are a standard provider of medical services and modern laboratories of Biopathology and Microbiology, Molecular Biology and Cytogenetics, Male and Female Infertility as well as specialized Nutrition and Dietetics departments. (biomedigen.gr)
High-risk cytogenetics4
- Isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma patients with high-risk cytogenetics: IKEMA subgroup analysis. (bvsalud.org)
- Isa-Kd) significantly improved progression-free survival (PFS) versus Kd in patients with relapsed MM. This prespecified subgroup analysis of IKEMA examined efficacy and safety in patients with high- risk cytogenetics . (bvsalud.org)
- Isa-Kd is a new treatment option for the difficult-to-treat subgroup of patients with relapsed MM and high- risk cytogenetics . (bvsalud.org)
- Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. (springermedizin.at)
Chromosomes5
- Rice cytogenetics is used to identify differences in the DNA or chromosomes by examining the chromosomes found in the root tips (mitotic cells) of rice plants or the chromosome pairing found in immature pollen (meiotic cells). (usda.gov)
- Molecular cytogenetics provides a toolbox of methods for DNA sequence visualization on nucleus or chromosomes bridging the gap between In Silico genome research and In Vivo genome organization. (alliedacademies.org)
- Cytogenetics is the discipline that studies the number and structure of chromosomes. (eurofins-biomnis.com)
- All these aberrations in the chromosomes can cause disease.Cytogenetics is the genetic discipline that examines chromosomes for such abnormalities. (x-omics.nl)
- In other circumstances, the testing method was neither germline or somatic, but used other means for identifying genetic risk (e.g., family history), or diagnosis, including biomarkers (objective measures of a biological state or condition within cells or organisms) and cytogenetics (the study of chromosomes and their inheritance). (cdc.gov)
Fluorescence in situ hybri1
- On the basis of techniques, the molecular cytogenetics market is segmented into comparative genomic hybridization, fluorescence in situ hybridization, in situ hybridization, and other techniques. (marketsandmarkets.com)
Genetic2
- Based on applications, the molecular cytogenetics market is segmented into genetic disorders, cancer, personalized medicine, and other applications. (marketsandmarkets.com)
- In addition to coding for disease/condition and application focus, we reviewed each guideline document to identify whether guideline related to germline or somatic genetic testing, or involved another testing method (e.g., family history, biomarkers, cytogenetics). (cdc.gov)
Karyotype1
- Many cytogenetics studies have search to understand the evolution of macro and micro karyotype structure of these different groups of fish, and classical and molecular cytogenetics techniques have contributed significantly for all knowledge of this karyotypic diversity. (intechopen.com)
Clinical2
- Clinical Cytogenetics is a branch of science that deals with the study & interpretation of chromosomal changes & structures. (datacaptive.com)
- Epidemiology, cytogenetics and clinical features. (bvsalud.org)
Favorable1
- Infants tend to have fewer favorable cytogenetics compared to children 2 years and older. (hematologyadvisor.com)
Methods1
- Methods 112 myeloma cases were analysed by whole bone marrow cytogenetics and by FISH and array CGH performed on purified plasma cell populations. (bmj.com)
Diagnosis3
- Cytogenetics is a mandatory investigation and is performed at baseline and at successive follow ups thereby helping in diagnosis, classifying patients into different risk groups, guiding clinicians in deciding treatment and monitoring response. (actrec.gov.in)
- Cytogenetics affect diagnosis and prognosis in pediatric acute myeloid leukemia (AML), a rare type of cancer in children. (hematologyadvisor.com)
- Pediatric patients respond better to intensive therapy, and defining cytogenetics at diagnosis helps patients benefit from tailored therapy. (hematologyadvisor.com)
Comparative1
- Comparative cytogenetics of mouse and human lung adenocarcinoma. (cdc.gov)
Specialties1
- Hello, I invite you to consult the site www.biomnis.com, on page Cytogenetics https://preprod21.eurofins-biomnis.com/en/specialties/cytogenetics/ Best regards. (eurofins-biomnis.com)
Abnormalities2
- Results Clonal abnormalities were identified in 30% of cases by cytogenetics and 97% by FISH and array CGH. (bmj.com)
- FISH is more sensitive than routine cytogenetics for various abnormalities, and is faster as well. (shyamhemoncclinic.com)
Perspectives2
- In November 1970, approximately 90 cytogeneticists convened at Colorado Springs, Colo, to participate in a conference titled "Perspectives in Cytogenetics. (jamanetwork.com)
- TOWNES PL. Perspectives in Cytogenetics. (jamanetwork.com)
FISH2
- An ultra-sensitive method termed tyramide-FISH (tyr-FISH) was adapted for plant cytogenetics [ 2 ]. (alliedacademies.org)
- Different techniques are available for their detection including cytogenetics, Fluorescent In Situ Hybridisation (FISH) and array Competitive Genomic Hybridisation (CGH). (bmj.com)
Cancer18
- Cancer Cytogenetics Department comprises of service and research programs. (actrec.gov.in)
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- Crespin too is to the download cancer cytogenetics third of Helpless Floria Toscas, Moroccan to my, and clear values varied two ve: Maria Callas( the own music, recorded by De Sabata) and Leontyne Price( two representative photographs: with Karajan and with Mehta). (denkotainment.de)
20022
- Byus (1984) y Paulraj (2002) reportaron una disminución de la actividad de la proteína quinasa en las ratas después de la exposición a la radiación de la RF. (rfcom.ca)
- Varios estudios han mostrado un aumento en los niveles de ODC después de la exposición a un campo EM (Byus, 1997, Paulraj, 2002). (rfcom.ca)
Mandatory1
- 4 . ALL: same as AML - mandatory to check cytogenetics and at least rule out Philadelphia chromosome. (shyamhemoncclinic.com)
Novo1
- A review article published in Genes provided updated details on cytogenetics in pediatric AML, with a focus on de novo AML, which represents about 95% of cases. (hematologyadvisor.com)
Botany1
- Edavaleth Kakkat Janaki Ammal is considered a pioneer in Botany who worked on plant breeding, cytogenetics and phytogeography. (atomstalk.com)
Assessment1
- Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. (elsevier.com)
Review1
- 1 The purpose of the conference sponsored by the National Institute of Child Health and Human Development was to review the remarkable advances in cytogenetics of the preceding decade and to peer into the decade ahead. (jamanetwork.com)
Significantly1
- In multivariate analysis, secondary AML (P = .0035), unfavorable cytogenetics (P = .0031), and MDR1 (P = .0041) were each significantly and independently associated with lower CR rates. (elsevier.com)
Service1
- The cytogenetics service lab will be closed for the Holidays. (tamu.edu)
Techniques1
- Considerations for population monitoring using cytogenetics techniques ICPEMC publication 14. (bvsalud.org)
Research2
- This industrial research report exhibits all the important information identified with the specific product for the Molecular Cytogenetics market with the exceptionally illuminating organization. (pharmiweb.com)
- Our mission is to provide state-of-the-art molecular cytogenetics services to support the cutting-edge research of the institute. (sanger.ac.uk)
Disease1
- Resistant disease was associated with unfavorable cytogenetics (P = .017) and MDR1 expression (P = .0007). (elsevier.com)
Patients1
- Evaluating pediatric patients based on cytogenetics and molecular subtypes helps match patients to risk-adapted therapies. (hematologyadvisor.com)
Analysis1
- Additional benefits include a higher resolution of the chromosome bands, enabling a deeper look at the cytogenetics resulting in faster and more accurate analysis. (accesswire.com)
Years1
- We are staffed with highly experienced certified Cytogenetics Technologists with an average 19 years of experience in the field. (wisconsindiagnostic.com)