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CytogeneticsCytogenetic AnalysisChromosome AberrationsKaryotypingIn Situ Hybridization, FluorescenceLeukemia, Myeloid, AcuteTranslocation, GeneticMyelodysplastic SyndromesChromosome BandingLeukemia, MyeloidChromosome DisordersChromosome PaintingInterphaseMonosomyAbnormal KaryotypeTrisomyAneuploidyPrognosisKaryotypeRemission Inductionfms-Like Tyrosine Kinase 3Chromosomes, HumanLeukemia, Myelomonocytic, AcuteChromosomes, Human, Pair 11Chromosome DeletionChromosomes, Human, Pair 8Acute DiseaseMetaphaseNeoplasms, Adipose TissueChromosomes, Human, Pair 13Chromosome InversionChromosomes, Human, Pair 14Chromosomes, Human, Pair 5Chromosomes, Human, Pair 18Chromosomes, Human, Pair 15Gene RearrangementCytarabineBone MarrowChromosomes, Human, Pair 7Anemia, Refractory, with Excess of BlastsMultiple MyelomaImmunophenotypingSurvival AnalysisDisease-Free SurvivalChromosomes, Human, Pair 17Spectral KaryotypingChromosomes, Human, Pair 16Precursor Cell Lymphoblastic Leukemia-LymphomaNeoplasm, ResidualDNA ProbesLeukemia, Lymphocytic, Chronic, B-CellTreatment OutcomeChromosomes, Human, Pair 21Tandem Repeat SequencesPloidiesSurvival RateOncogene Proteins, FusionChromosomes, Human, Pair 1Philadelphia ChromosomeHematopoietic Stem Cell TransplantationChromosomes, Human, Pair 3DaunorubicinLaurence-Moon SyndromeNucleic Acid HybridizationOrthopteraChromosome BreakageChromosomes, Human, Pair 2DigoxigeninTransplantation, HomologousAntineoplastic Combined Chemotherapy ProtocolsIsochromosomesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveIdarubicinBlast CrisisLeukemia, Promyelocytic, AcutePrenatal DiagnosisChromosomesRecurrenceChromosomes, Human, Pair 9Hematologic DiseasesChromosomes, Human, Pair 12MutationChromosomes, Human, Pair 20Life TablesChromosomes, Human, XY ChromosomeChromosomes, Human, Pair 22Retrospective StudiesRing ChromosomesLeukemia, Myelomonocytic, ChronicDNA, NeoplasmGene DuplicationComparative Genomic HybridizationPolymerase Chain ReactionTransplantation, AutologousChromosomes, Human, Pair 4Abnormalities, MultipleFlow CytometrySex Chromosome AberrationsGene Expression Regulation, LeukemicThalidomideChromosomes, Artificial, BacterialMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsGenetic MarkersBone Marrow TransplantationChromosome MappingIntellectual DisabilityTurner SyndromeCore Binding Factor Alpha 2 SubunitSplenic NeoplasmsChromosomes, Human, Pair 10LeukemiaMultivariate AnalysisMosaicismNeoplasms, Second PrimaryBone Marrow ExaminationGenetic TechniquesBone Marrow CellsTumor Markers, BiologicalStem Cell TransplantationGene DeletionCytodiagnosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaImmunoglobulin Heavy ChainsFusion Proteins, bcr-ablTransplantation ConditioningParaffin EmbeddingOligonucleotide Array Sequence AnalysisChromosomes, Human, Pair 19X ChromosomeKaplan-Meier EstimateReverse Transcriptase Polymerase Chain ReactionAntineoplastic AgentsRisk FactorsMitotic IndexNuclear ProteinsDNA Copy Number VariationsCombined Modality TherapyChromosomal InstabilityLeukocyte CountAnemia, AplasticFalse Negative ReactionsDNA, SatelliteChromosomes, PlantVidarabineAntigens, CD34Follow-Up StudiesLymphoma, Non-HodgkinPolyploidySensitivity and SpecificityDNA Mutational AnalysisBusulfanGene Expression ProfilingHematologic NeoplasmsPhenotypeEvaluation Studies as TopicLymphoma, B-CellGene AmplificationAge FactorsInfant, NewbornProspective StudiesCentromereLymphomaAzacitidineCohort StudiesSalvage TherapyGene DosageDown SyndromeProto-Oncogene ProteinsSyndromeIn Situ HybridizationAntimetabolites, AntineoplasticHodgkin DiseaseChimeraLoss of Heterozygosity
Cytogenetics: A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.Cytogenetic Analysis: Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Karyotyping: Mapping of the KARYOTYPE of a cell.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Translocation, Genetic: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Chromosome Banding: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Chromosome Disorders: Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)Chromosome Painting: A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.Interphase: The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).Monosomy: The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.Abnormal Karyotype: A variation from the normal set of chromosomes characteristic of a species.Trisomy: The possession of a third chromosome of any one type in an otherwise diploid cell.Aneuploidy: The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Karyotype: The full set of CHROMOSOMES presented as a systematized array of METAPHASE chromosomes from a photomicrograph of a single CELL NUCLEUS arranged in pairs in descending order of size and according to the position of the CENTROMERE. (From Stedman, 25th ed)Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.fms-Like Tyrosine Kinase 3: A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute MYELOID LEUKEMIA.Chromosomes, Human: Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.Leukemia, Myelomonocytic, Acute: A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.Chromosomes, Human, Pair 11: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Chromosome Deletion: Actual loss of portion of a chromosome.Chromosomes, Human, Pair 8: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Acute Disease: Disease having a short and relatively severe course.Metaphase: The phase of cell nucleus division following PROMETAPHASE, in which the CHROMOSOMES line up across the equatorial plane of the SPINDLE APPARATUS prior to separation.Neoplasms, Adipose Tissue: Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.Chromosomes, Human, Pair 13: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Chromosome Inversion: An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.Chromosomes, Human, Pair 14: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Chromosomes, Human, Pair 5: One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).Chromosomes, Human, Pair 18: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Chromosomes, Human, Pair 15: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Gene Rearrangement: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Chromosomes, Human, Pair 7: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Anemia, Refractory, with Excess of Blasts: Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Chromosomes, Human, Pair 17: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Spectral Karyotyping: The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.Chromosomes, Human, Pair 16: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Leukemia, Lymphocytic, Chronic, B-Cell: A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Chromosomes, Human, Pair 21: A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.Tandem Repeat Sequences: Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).Ploidies: The degree of replication of the chromosome set in the karyotype.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Oncogene Proteins, Fusion: The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.Chromosomes, Human, Pair 1: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Philadelphia Chromosome: An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.Laurence-Moon Syndrome: An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Orthoptera: An order of insects comprising two suborders: Caelifera and Ensifera. They consist of GRASSHOPPERS, locusts, and crickets (GRYLLIDAE).Chromosome Breakage: A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.Chromosomes, Human, Pair 2: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Digoxigenin: 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Isochromosomes: Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Idarubicin: An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.Blast Crisis: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Chromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Recurrence: The return of a sign, symptom, or disease after a remission.Chromosomes, Human, Pair 9: A specific pair of GROUP C CHROMSOMES of the human chromosome classification.Hematologic Diseases: Disorders of the blood and blood forming tissues.Chromosomes, Human, Pair 12: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Chromosomes, Human, Pair 20: A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.Chromosomes, Human, X: The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.Y Chromosome: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.Chromosomes, Human, Pair 22: A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Ring Chromosomes: Aberrant chromosomes with no ends, i.e., circular.Leukemia, Myelomonocytic, Chronic: A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.DNA, Neoplasm: DNA present in neoplastic tissue.Gene Duplication: Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.Comparative Genomic Hybridization: A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Chromosomes, Human, Pair 4: A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.Abnormalities, MultipleFlow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Sex Chromosome Aberrations: Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.Gene Expression Regulation, Leukemic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Myeloid-Lymphoid Leukemia Protein: Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)Turner Syndrome: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.Core Binding Factor Alpha 2 Subunit: A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.Splenic Neoplasms: Tumors or cancer of the SPLEEN.Chromosomes, Human, Pair 10: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Mosaicism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Genetic Techniques: Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Cytodiagnosis: Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.Immunoglobulin Heavy Chains: The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.Fusion Proteins, bcr-abl: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Paraffin Embedding: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Chromosomes, Human, Pair 19: A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.X Chromosome: The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mitotic Index: An expression of the number of mitoses found in a stated number of cells.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.DNA Copy Number Variations: Stretches of genomic DNA that exist in different multiples between individuals. Many copy number variations have been associated with susceptibility or resistance to disease.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.False Negative Reactions: Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)DNA, Satellite: Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Vidarabine: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Polyploidy: The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Busulfan: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Infant, Newborn: An infant during the first month after birth.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Centromere: The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Syndrome: A characteristic symptom complex.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Chimera: An individual that contains cell populations derived from different zygotes.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

How identical would cloned children be? An understanding essential to the ethical debate. (1/486)

The ban on human cloning in many countries worldwide is founded on an assumption that cloned children will be identical to each other and to their nuclear donor. This paper explores the scientific basis for this assumption, considering both the principles and practice of cloning in animals and comparing genetic and epigenetic variation in potential human clones with that in monozygotic twins.  (+info)

Immunocytogenetic detection of normal and abnormal oocytes in human fetal ovarian tissue in culture. (2/486)

This study aimed to: (i) determine whether oocytes are present in cultures of human fetal ovary; (ii) identify whether meiotic anomalies are evident; and (iii) assess whether preparation or culture conditions influence oocyte survival and meiotic progression. Ovaries were collected from fetuses after termination at 13-16 weeks. Oocyte assessment utilized antibodies specific for synaptonemal complex proteins (associated with chromosomes only during meiosis), and antibodies to centromeric proteins. Fragments of tissue were cultured in minimal essential medium + 10% serum +/- follicle stimulating hormone (100 mIU/ml). The sera were fetal calf serum (FCS), FCS for embryonic stem cells (ES-FCS) and human female serum. The numbers and stages of oocytes were assessed after 7-40 days, and particular arrangements of chromosome synapsis identified. Results in fresh tissue included oocytes at leptotene, zygotene, pachytene and diplotene in three of five samples. Four specimens remained viable in vitro, and three had detectable oocytes after culture. The numbers of oocytes and the proportions of zygotene and pachytene cells increased with time in culture. The proportion of degenerate cells in culture was initially higher than in fresh samples, but declined subsequently. More oocytes were detected in ES-FCS and human serum than in FCS. We conclude that human oocytes survive in culture and that progression through prophase I continues.  (+info)

Danish National In-Vitro Fertilization Registry 1994 and 1995: a controlled study of births, malformations and cytogenetic findings. (3/486)

This paper reports data from the Danish in-vitro fertilization (IVF) registry from 1994 to 1995 including data on treatments and the results of these (perinatal outcome, cytogenetic findings and fetal malformations) in comparison with a control group matched for maternal age, parity, multiplicity and year of birth. There were 1756 deliveries of 2245 children (24.3% twins, 1.8% triplets). The rate of prematurity among IVF children was 23.8% (NS) [singletons 7. 3% (P < 0.05), twins 41.2% and triplets 93.5%], 23.6% weighed <2500 g [singletons 7% (P < 0.05), twins 42.2% and triplets 87.1%]. The perinatal mortality rate was 21.8 in the study group compared to 17. 4 in the control group (NS). In total, 13.2% of all clinical pregnancies and 15.4% of the pregnancies that resulted in a delivery had a prenatal genetic examination. Of all examined, 3.5% had an abnormal karyotype. In total, 107 (4.8%) children in the study group and 103 (4.6%) in the control group were born with malformations (NS), compared to 2.8% in the background population. Our results indicate that it is the characteristics of the patients and multiplicity of pregnancy, rather than the assisted reproductive technology that determines the fetal risks of IVF pregnancies compared to the background population.  (+info)

AlphaIFN-induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5). (4/486)

Chronic eosinophilic leukemia (CEL) is a myeloproliferative disease characterized by excessive eosinophilic proliferation with clonal cytogenetic abnormalities. The most frequent cytogenetic abnormality is a break in the q 31-35 region of chromosome 5, where genes encoding for IL-3, IL-5 and GM-CSF (all cytokines involved in eosinophilopoiesis) are located. We report the case of a patient with CEL with t(1;5) (q23;q31), who obtained complete hematologic and major cytogenetic response after two years of alpha-interferon (alpha-IFN) therapy. Two other cases of complete response to alpha-IFN are reported in the literature. A trial with alpha-IFN could be considered as front line treatment in this rare disease.  (+info)

CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. (5/486)

OBJECT: We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma. METHODS: These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis. MATERIALS: Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated. RESULTS: The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. All had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CD5 and CD8. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CD5, CD10 and CD13 in patient 1, CD5 in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jdelta1 induced by T-cell specific enhancer. Rearrangement of TCR beta and gamma genes occurred in patient 2, and IgH and TCR beta underwent rearrangement in patient 3. CONCLUSION: Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage.  (+info)

A survey of 1,000 cases referred for cytogenetic study to King Khalid University Hospital, Saudi Arabia. (6/486)

We reviewed cytogenetic studies that have been done in 1,000 consecutive non-oncology samples that were referred to the Cytogenetics Unit at King Khalid University Hospital, Riyadh, Saudi Arabia. The cases were grouped according to the referral diagnosis and the requested cytogenetic service. The frequency of the different types of numerical and structural abnormalities was determined and the relative frequency of cases with abnormal karyotype was calculated in each group. This study should assist physicians in Saudi Arabia and surrounding countries by increasing the awareness of the frequency of cytogenetic abnormality in different diagnostic groups. It also gives figures for comparison with other countries and research centers.  (+info)

Biodosimetry results obtained by various cytogenetic methods and electron spin resonance spectrometry among inhabitants of a radionuclide contaminated area around the siberian chemical plant (Tomsk-7). (7/486)

On April 6, 1993, near the town of Tomsk (Russia) there was an accident at the Siberian Chemical Plant (SCP) which resulted in extensive contamination of an area of 250 km(2) to the north of SCP with long-lived radionuclides such as (239)Pu, (137)Cs and (90)Sr. Cytogenetic methods and electron spin resonance (ESR) spectrometry of tooth enamel were used to estimate the radiation doses received by the population. The ESR signal intensity and the chromosomal aberration frequency in lymphocytes of the tooth donors showed a good correlation. The data showed that 15% of the inhabitants of the Samus settlement received a radiation dose >90 cGy. The exceptions were results of an examination of fishermen, where ESR gave high values (80-210 cGy) but both the chromosome assay and the cytokinesis block micronucleus method gave lower ones (8-52 cGy). A large increase in chromosome damage was observed in people born between 1961 and 1969. It was found that during these years several serious accidents at the Siberian Chemical Plant had occurred causing radiation pollution of the area. The number of cells with chromosome aberrations was significantly less among the people arriving in Samus after 1980. We found good correlations between the level of carotene consumption and a decrease in frequency of both micronuclei in binucleated lymphocytes (r = 0.68, P < 0.01) and chromatid aberrations (r = 0.61, P < 0.01) among the inhabitants. We also examined the inhabitants of Samus for opisthorchis infection, which was present in 30% of the population. The Samus inhabitants affected by Opisthorchis felineus showed significantly increased levels of micronuclei in binucleated lymphocytes and chromatid aberrations as compared with the controls.  (+info)

Processing of DNA damage induced by hydrogen peroxide and methyl methanesulfonate in human lymphocytes: analysis by alkaline single cell gel electrophoresis and cytogenetic methods. (8/486)

The persistence of induced DNA damage in human lymphocytes after mitogen stimulation and its relationship to subsequent cytogenetic alterations were investigated. The analysis of single-strand breaks and alkali-labile sites by single cell gel electrophoresis (SCGE) showed the almost complete repair of damage induced in resting lymphocytes by methyl methanesulfonate (MMS, 140-210 microM) and hydrogen peroxide (H(2)O(2), 25-100 microM) during the first 16 h of culture. On the other hand, DNA damage was shown to persist to a large extent when cells were cultured in the presence of the repair inhibitor cytosine beta-D-arabinofuranoside (Ara-C) (1 microg/ml). Although highly effective in the induction of DNA lesions detectable by SCGE, both agents failed to significantly increase the rate of micronucleus formation in cytokinesis-blocked cells harvested 66 h after treatment. However, when Ara-C was present during the first 16 h of culture, micronuclei were significantly increased at all doses. Conversely, sister chromatid exchange (SCE) rates were increased by chemical treatments to a higher extent in cultures without Ara-C. Delayed treatments, 16 h after mitogen stimulation, led to a significant induction of micronuclei in the case of MMS but not with H2O(2). These results suggest that only a minor fraction of DNA damage induced in resting lymphocytes is available for fixation through misreplication, because of its effective repair prior to S phase. However, the processing of damage through recombination pathways can lead to increased SCE rates in treated cells. These features of the processing of DNA damage in human lymphocytes should be taken into account when structural cytogenetic alterations in cultured lymphocytes are used in monitoring human exposure to genotoxic agents.  (+info)

Work in Arizona Jobs - Cytogenetics Director / Clinical Cytogeneticist- Integrated Oncology in Phoenix, Arizona, United StatesWork in Arizona Jobs - Cytogenetics Director / Clinical Cytogeneticist- Integrated Oncology in Phoenix, Arizona, United States
Integrated Oncology, a division of LabCorp, has an immediate opening for a Cytogenetics Director in Phoenix, AZ. Integrated Oncology is a national specialty reference laboratory providing state-of-the-art diagnostic oncology services. We provide a comprehensive cancer-testing center in which cytogeneticists and molecular geneticists work closely with pathologists, flow cytometry analysts and immunohistochemistry histologists to provide high quality oncology testing services. ABMGG Board-certified Clinical Cytogenetics directors or Active Candidates (board eligible) are encouraged to apply.. The Cytogenetics Director will be responsible for the management of technical and scientific operation within an assigned clinical Cytogenetics and FISH Laboratory department, including accurate reporting of patient results, case review, and reviewing validation data.. Responsibilities:. ...
Browse In Clinical Cytogenetics and Molecular Genetics - Oxford Medicine Online - Oxford MedicineBrowse In Clinical Cytogenetics and Molecular Genetics - Oxford Medicine Online - Oxford Medicine
The goal of this resource is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. Topics reviewed include investigations in genome architecture, gene structure, gene regulation epigenetic modifications and function of organelles including mitochondria, and the endosome lysosome system. New insights into neurodevelopment and neurobehavioral disorders gained through functional genomic research are presented and aspects of genomic studies in complex common diseases are reviewed. Less ...
Dr. Eugene Pergament, MD - Chicago, IL - Clinical Genetics & Clinical Cytogenetics | Healthgrades.comDr. Eugene Pergament, MD - Chicago, IL - Clinical Genetics & Clinical Cytogenetics | Healthgrades.com
Visit Healthgrades for information on Dr. Eugene Pergament, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Molecular Cytogenetics Market worth 2.52 Billion USD by 2021Molecular Cytogenetics Market worth 2.52 Billion USD by 2021
Early buyers will receive 10% customization on reports.. The molecular cytogenetics market is projected to reach USD 2.52 Billion by 2021 from USD 1.55 Billion in 2016, at a CAGR of 10.1% from 2016 to 2021. The major factors driving the growth of this market are increasing incidence of genetic disorders and cancer, rapid growth in the aging population, and growing healthcare expenditure worldwide.. The report segments this market based on product, technique, application, end user, and region. Among the products, kits and reagents are expected to account for the largest share of the market. The high growth of kits and reagents segment can be attributed to the increasing number of rental agreements and increasing use of kits and reagents in diagnosis of genetic disorders and cancer worldwide.. On the basis of techniques, the molecular cytogenetics market is segmented into comparative genomic hybridization, fluorescence in situ hybridization, in situ hybridization, and other techniques.. Based on ...
Molecular Cytogenetics Market Size & Share | Industry Report, 2022Molecular Cytogenetics Market Size & Share | Industry Report, 2022
The global molecular cytogenetics market was valued at USD 817.5 million in 2015. The increasing incidence of congenital & genetic disorders and the subsequent rise in the early disease diagnostics is expected to boost the demand for molecular cytogenetics over the forecast period
Molecular Cytogenetics Market - Global Industry Analysis, Size and Forecast, 2016 to 2026Molecular Cytogenetics Market - Global Industry Analysis, Size and Forecast, 2016 to 2026
Molecular Cytogenetics Market - Global industry segment analysis, regional outlook, share, growth; molecular cytogenetics market forecast 2016 to 2026 by future market insights
Oxford Index Browse - oiOxford Index Browse - oi
Megan C. Smith, Megan K. Kressin, Eric Crawford, Xuan J. Wang and Annette S. Kim.. in Laboratory Medicine. November 2015; p ublished online November 2015 . Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics; Haematology; Molecular and Cell Biology; Molecular Biology and Genetics. 2772 words. ...
Multiple samples aCGH analysis for rare CNVs detection | Journal of Clinical Bioinformatics | Full TextMultiple samples aCGH analysis for rare CNVs detection | Journal of Clinical Bioinformatics | Full Text
To validate segments selected as rare CNVs according to our density score we automate the process of a manual validation of segments based on UCSC [29], i.e. the protocol by which geneticians usually act. Lastly, we compare resulting sets of segments with the set produced manually by geneticists from IMC.. Manual validation by geneticists involves inspecting reported CNVs segments, overlaying them on UCSC tracks. This purposes to filter out known polymorphisms and, by interrogation of all known syndrome regions, to try to narrow down the segment set to only those clinically relevant. This step is followed by FISH or PCR confirmation of the CNVs existence in patients DNA [30, 31].. For the automated process we decided to focus on three main databases storing the information related to genomic variations and diseases resulting from it: ISCA, DGV and GAD.. ISCA is a group of clinical cytogenetics laboratories committed to improve the quality of patients care related to clinical genetic testing ...
Stony Brook Undergraduate Bulletin - Fall 2011 - HAEAboutStony Brook Undergraduate Bulletin - Fall 2011 - HAEAbout
Clinical laboratory scientists utilize a wide variety of sophisticated equipment and skills to perform tests that analyze specimens to produce data for the diagnosis, prevention and treatment of disease. Many of the same tests are used for organ transplants, therapeutic drug monitoring, crime investigation, genetic studies and research. The program now offers three specializations (Forensic Medical Diagnostics, Laboratory Infor-mation Systems and Clinical Cytogenetics) within its traditional clinical laboratory curriculum. A double major in clinical laboratory sciences and biology is available ...
Molecular Cytogenetics | MutagenesisMolecular Cytogenetics | Mutagenesis
One of the worlds leading journals dedicated to cytogenetics and cytogenomics, Molecular Cytogenetics encompasses all aspects of chromosome biology and the ...
Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507
Buy, download and read Plant Cytogenetics, Second Edition ebook online in PDF format for iPhone, iPad, Android, Computer and Mobile readers. Author: Ram J. Singh. ISBN: 9781420038507. Publisher: CRC Press. Plant cytogenetics has progressed at a rapid rate since the publication of the first edition. Plant Cytogenetics, Second Edition presents an up-to-date review of cytogenetics. It covers the latest in
Global Molecular Cytogenetics Market 2014-2018Global Molecular Cytogenetics Market 2014-2018
Molecular Cytogenetics involves the study of chromosomes using molecular biology to understand the role and functions of genes and chromosomes. It plays a crucial role in the early diagnosis of a
Molecular Cytogenetics Market Will Grow Rapidly Owing To Rising Incidence Of Congenital And Genetic Disorders Till 2022: Grand...Molecular Cytogenetics Market Will Grow Rapidly Owing To Rising Incidence Of Congenital And Genetic Disorders Till 2022: Grand...
Global molecular cytogenetics market is expected to reach nearly USD 3.6 billion by 2022, according to a new report by Grand View Research, Inc. Increasing
Citation Machine: Molecular Cytogenetics format citation generator for congressional publicationCitation Machine: Molecular Cytogenetics format citation generator for congressional publication
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your congressional publication in Molecular Cytogenetics format for free.
Cytogenetics GalleryCytogenetics Gallery
Information on the University of Washington and the Department of Pathology Cytogenetics Gallery. Includes informative description of Cytogenetics.
Cytogenetics GalleryCytogenetics Gallery
Information on the University of Washington and the Department of Pathology Cytogenetics Gallery. Includes informative description of Cytogenetics.
Cell Culture - Cytogenetics Core - Mayo Clinic ResearchCell Culture - Cytogenetics Core - Mayo Clinic Research
Cell culture services can be used to produce the appropriate material for cytogenetic analysis from the investigators original specimen or sample. For example, the core can produce metaphases for cytogenetic analysis or karyotypes from an investigators cell line of interest.. In addition, the core can initiate the culturing of raw specimens, such as tumors, without subsequent cytogenetic analysis for the investigator. A range of tissues, animal models and culture systems are commonly used by the Cytogenetics Core.. ...
Superdomestication, feed-forward breeding and climate proofing crops | Molecular cytogenetics and genome evolutionSuperdomestication, feed-forward breeding and climate proofing crops | Molecular cytogenetics and genome evolution
Climate Proofing of Food Crops, through genetic improvement for adaptation, is an important, medium-term, objective to ensure food-security and increase production while enhancing the sustainability of agriculture. The IAEA has a Coordinated Research Project discussing this topic (archive version). In the YouTube video here, I discuss some of the challenges plant researchers are addressing, and…
KAKEN - Research Projects | Studies on characteristics of molecular cytogenetics and demography in certain endangered plant...KAKEN - Research Projects | Studies on characteristics of molecular cytogenetics and demography in certain endangered plant...
Principal Investigator：KONDO Katsuhiko, Project Period (FY)：2002 - 2005, Research Category：Grant-in-Aid for Scientific Research (A), Section：海外学術, Research Field：生物資源科学
Fish CytogeneticsFish Cytogenetics
... http://ecx.images-amazon.com/images/I/41RtoqjwlUL._SS500_.jpg By E Pisano (Editor), C. Ozouf-Costaz (Editor), F. Foresti (Editor)
Cancer Cytogenetics SolutionsCancer Cytogenetics Solutions
Clinical researchers can obtain a complete view of cancer cytogenetics by combining next-generation sequencing (NGS) and microarrays.
20 Best Cytogenetics Tech jobs (Hiring Now!) | Simply Hired20 Best Cytogenetics Tech jobs (Hiring Now!) | Simply Hired
Browse 20 Cytogenetics Tech job listings from companies with openings that are hiring now. Quickly find your next job opportunity at Simply Hired.
Microarray with Karyotype (20 cell Analysis): CytogeneticsMicroarray with Karyotype (20 cell Analysis): Cytogenetics
Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data. UNC ...
Definition of CytogeneticsDefinition of Cytogenetics
TeachMeFinance.com is an informational website, and should not be used as a substitute for professional medical, legal or financial advice. Information presented at TeachMeFinance.com is provided on an "AS-IS" basis. Please read the disclaimer for details. ...
CYTOGENETICS | KARYOCYTOGENETICS | KARYO
KARYO LTD was founded in 2008. Since then we provide services of high quality in the fields of genetic material analysis to the health providers. Our strong commitment remains the reliability and validity of our results, along with fast response and low end user price.. ...
Human interphase chromosomes: a review of available molecular cytogenetic technologies | Molecular Cytogenetics | Full TextHuman interphase chromosomes: a review of available molecular cytogenetic technologies | Molecular Cytogenetics | Full Text
Human karyotype is usually studied by classical cytogenetic (banding) techniques. To perform it, one has to obtain metaphase chromosomes of mitotic cells. This leads to the impossibility of analyzing all the cell types, to moderate cell scoring, and to the extrapolation of cytogenetic data retrieved from a couple of tens of mitotic cells to the whole organism, suggesting that all the remaining cells possess these genomes. However, this is far from being the case inasmuch as chromosome abnormalities can occur in any cell along ontogeny. Since somatic cells of eukaryotes are more likely to be in interphase, the solution of the problem concerning studying postmitotic cells and larger cell populations is interphase cytogenetics, which has become more or less applicable for specific biomedical tasks due to achievements in molecular cytogenetics (i.e. developments of fluorescence in situ hybridization -- FISH, and multicolor banding -- MCB). Numerous interphase molecular cytogenetic approaches are restricted
Cytogenetics | Sydney Childrens Hospitals NetworkCytogenetics | Sydney Children's Hospitals Network
Welcome to the Cytogenetics Department at The Childrens Hospital at Westmead (CHW). The Cytogenetics and the Molecular Genetics laboratory form the Sydney Genome Diagnostics (SGD) group at CHW. We provide a NATA accredited service for the diagnosis of a wide range of constitutional (blood), prenatal and acquired [leukaemia, lymphoma and tumour] chromosome disorders.
Cytogenetics LaboratoryCytogenetics Laboratory
The Cytogenetics Laboratory performs chromosome analysis, fluorescence in situ hybridization (FISH) and single nucleotide polymorphism (SNP) microarray testing.
9;22 translocation - Cytogenetics Today9;22 translocation - Cytogenetics Today
The Ph chromosome is the most frequent rearrangement in adult ALL. some patients have had both B-cell and myeloid markers . Because of the high frequency of the BCR/ABL rearrangement and its dire clinical consequences, molecular studies using RT-PCR should be routinely performed at diagnosis when clinical suspicion is high and cytogenetic analysis is nondiagnostic.. ...
Ráðstefna um litningarannsóknir í Póllandi í september | LíffræðigáttinRáðstefna um litningarannsóknir í Póllandi í september | Líffræðigáttin
Við fengum tilkynningu um áhugaverða ráðstefnu á sviði litningarannsókna í plöntum. Hér fylgir stutt lýsing á ensku um ráðstefnuna, og viðhangandi er PDF veggspjald.. PLANT MOLECULAR CYTOGENETICS IN GENOMIC AND POSTGENOMIC ...
Reviewer acknowledgement 2014 by Thomas Liehr, Henry Heng et al."Reviewer acknowledgement 2014 " by Thomas Liehr, Henry Heng et al.
Contributing reviewers The Editors of Molecular Cytogenetics would like to thank all our reviewers who have contributed to the journal in volume 6 (2013).
Cytogenetics Today - Just another WordPress siteCytogenetics Today - Just another WordPress site
The Ph chromosome is the most frequent rearrangement in adult ALL. some patients have had both B-cell and myeloid markers . Because of the high frequency of the BCR/ABL rearrangement and its dire clinical consequences, molecular studies using RT-PCR should be routinely performed at diagnosis when clinical suspicion is high and cytogenetic analysis is nondiagnostic.. ...
Interphasezytogenetik mit DNA-sonden für chromosom 8 zur detektion zirkulierender tumorzellen beim mammakarzinom<...Interphasezytogenetik mit DNA-sonden für chromosom 8 zur detektion zirkulierender tumorzellen beim mammakarzinom<...
TY - JOUR. T1 - Interphasezytogenetik mit DNA-sonden für chromosom 8 zur detektion zirkulierender tumorzellen beim mammakarzinom. AU - Ghadimi, B. M.. AU - Uhr, J.. AU - Tucker, Th. AU - Heselmeyer-Haddad, K.. AU - Auer, G.. AU - Ried, Th. AU - Becker, H.. PY - 2001. Y1 - 2001. N2 - The detection of micrometastases in the bone marrow or peripheral blood of cancer patients is increasingly used for a more sensitive tumor staging and prognostication. The potential value of the currently used techniques for the detection of epithelial antigens by RT-PCR or immunohistochemistry in respect of specificity is currently controversially discussed. In the present study we demonstrate a new approach which enables the direct visualization of the tumor specific alteration of chromosome 8 in circulating tumor cells. We have therefore studied breast cancer patients with various tumor stages and tried to determine the frequency of circulating tumor cells in the peripheral blood by using interphase cytogenetics ...
Principles and Applications of PRINS in Cytogenetics - Current ProtocolsPrinciples and Applications of PRINS in Cytogenetics - Current Protocols
A flexible, low‐cost alternative to FISH, primed in situ labeling (PRINS) has traditionally been used to detect tandemly repeated target sequences in chromosomes and nuclei
PLNT3140 Introductory Cytogenetics - Lecture 4, part 2 of 2PLNT3140 Introductory Cytogenetics - Lecture 4, part 2 of 2
Fixation is the preservation of all cellular and structural elements in as nearly the natural living condition as possible. The role of the fixative is to fix or stop the cells at the desired stage of cell division without causing distortion, swelling or shrinkage of the chromosomes or with as little chemical and structural change of cell constituents as possible. It is required primarily in order that structures which are obscured or entirely invisible in the living cell may be made clearly visible and secondarily that the soft structures may be hardened sufficiently for further treatment.. Several factors affect fixation including temperature, pH, osmolarity, rate of penetration, rate of chemical and physical changes and length of fixation. Poor fixation makes it impossible to obtain good results from sectioning and staining. Rules affecting Fixation ...
CONICET | Buscador de Institutos y Recursos HumanosCONICET | Buscador de Institutos y Recursos Humanos
GENOMIC REORGANIZATION OF SPECIES 2N = 20 OF ARACHIS SECTION Germán Robledo & Guillermo Seijo IBONE. Corrientes. Argentina Genome types A, B and D of section Arachis were originally established on the basis of karyotype morphology and cross compatibility assays of a few species. Currently. 26 species with 2n = 2x = 20 are included in the section, which were assigned to the A and B genomes. However, the interspecific hybrids fertility is not consistent with this genomic scheme, and the preliminary studies of molecular cytogenetics on a few species suggest a more heterogeneous karyotype. Therefore, in order to reappraise the genomic composition of the section we conducted a detailed karyotypic characterization of these species by analyzing the distribution patterns of C-DAPI+ heterochromatin and ribosomal genes by FISH. This study revealed a high karyotype variability, upon which five karyotypic groups were established. Each one has a distinctive structural organization. Two of these groups ...
Emerging Approaches in Acute Myeloid Leukemia - The ASCO PostEmerging Approaches in Acute Myeloid Leukemia - The ASCO Post
With the emergence of molecular diagnostics and new therapeutics, the treatment of acute myeloid leukemia (AML) is entering a new era. Hugo F. Fernandez, MD, Associate Chief of Blood and Marrow Transplantation at Moffitt Cancer Center in Tampa, Florida, spoke with The ASCO Post about how he approaches these patients.. Cytogenetics and Molecular Studies. Can you offer a few major requirements in treating AML today?. In 2014, we need to know the results of cytogenetics and molecular studies, which should be done on all patients with AML. Cytogenetics has long been a standard diagnostic test, and we classify cytogenetic profiles as conveying a "good (favorable), bad (intermediate), or ugly (unfavorable)" profile. Ten-year overall survival rates have been shown to be 55% to 81% for patients with favorable profiles, 22% to 39% for those with intermediate-risk profiles, and 10% or less for those with unfavorable profiles.1. But now we know about a variety of mutations that also confer prognosis. ...
Cyto-str - CYTOGENETICS CHROMOSOMAL ABERRATIONS PART II Structural Changes in Chromosomes There are 4 common types of...Cyto-str - CYTOGENETICS CHROMOSOMAL ABERRATIONS PART II Structural Changes in Chromosomes There are 4 common types of...
View Notes - Cyto-str from GENE 310 at Texas A&M. CYTOGENETICS; CHROMOSOMAL ABERRATIONS PART II: Structural Changes in Chromosomes There are 4 common types of structural aberrations; duplications,
George Fraser (1955-2014) Professor of Detector Physics and his biology | Molecular cytogenetics and genome evolutionGeorge Fraser (1955-2014) Professor of Detector Physics and his biology | Molecular cytogenetics and genome evolution
My colleagues and I were devastated by the news of the untimely death of our collaborator and friend George Fraser (22 July 1955 - 18 March 2014). George had a unique combination of vision of the applications of detector physics, knowledge from space research, optics, and electronics which is a huge loss to the whole…
IJBB AUG 2008IJBB AUG 2008
Received 12 January 2009; revised 02 June 2009. The study was undertaken to examine whether Carcinosin-200 (Car-200) could provide additional ameliorative effect, if used intermittently with Natrum sulphuricum-30 (Nat Sulph-30) against hepatocarcinogenesis induced by chronic feeding of p-dimethylaminoazobenzene (p-DAB) and phenobarbital (PB) in mice (Mus musculus). Mice were randomly divided into seven sub-groups: (i) normal untreated; (ii) normal + succussed alcohol; (iii) p-DAB (0.06%) + PB (0.05%); (iv) p-DAB + PB + succussed alcohol, (v) p-DAB + PB + Nat Sulph-30, (vi) p-DAB + PB + Car-200, and (vii) p-DAB + PB + Nat Sulph-30 + Car-200. They were sacrificed at 30, 60, 90 and 120 days for assessment of genotoxicity through cytogenetical end-points like chromosome aberrations, micronuclei, mitotic index and sperm head anomaly and cytotoxicity through assay of widely accepted biomarkers and pathophysiological parameters. Additionally, electron microscopic studies and gelatin zymography for ...
Plant breeding and cytogenetics by Fred C. Elliott | LibraryThingPlant breeding and cytogenetics by Fred C. Elliott | LibraryThing
All about Plant breeding and cytogenetics by Fred C. Elliott. LibraryThing is a cataloging and social networking site for booklovers
Single cell DNA sequencing to quantify karyotype heterogeneity in cancer - Research database - University of GroningenSingle cell DNA sequencing to quantify karyotype heterogeneity in cancer - Research database - University of Groningen
Bakker, B., van den Bos, H., Spierings, D. C. J. & Foijer, F., 5-Jul-2019, In : Molecular Cytogenetics. 12, 1 p.. Research output: Contribution to journal › Meeting Abstract › Academic ...
Publikationen | Prof. Dr. Dr. Christoph CremerPublikationen | Prof. Dr. Dr. Christoph Cremer
The list of publications gives a selection covering the fields of interest in Applied Optics, Digital Image Analysis, Bioinformatics, Biophysics and Biophotonics, Biomolecular Labelling Techniques, and applications in Molecular Cytogenetics and Nuclear Genome Structure Research.. ...
So Many To Choose From! - Rainbow Scientific, Inc.So Many To Choose From! - Rainbow Scientific, Inc.
Rainbow Scientific, Inc. (RSI) is a distributor of state-of-the-art scientific products to molecular cytogenetics, clinical chemistry, pathology and hemostasis laboratories across North America.
Floating Helix - Rainbow Scientific, Inc.Floating Helix - Rainbow Scientific, Inc.
Rainbow Scientific, Inc. (RSI) is a distributor of state-of-the-art scientific products to molecular cytogenetics, clinical chemistry, pathology and hemostasis laboratories across North America.
Investigaci n: Publicaciones Científicas | cnio.esInvestigaci n: Publicaciones Científicas | cnio.es
Mallo M, Del Rey M, Ibáñez M, Calasanz MJ, Arenillas L, Larráyoz MJ, Pedro C, Jerez A, Maciejewski J, Costa D, Nomdedeu M, Diez-Campelo M, Lumbreras E, González-Martínez T, Marugán I, Such E, Cervera J, Cigudosa JC, Alvarez S, Florensa L, Hernández JM, Solé F (2013). Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations. Br J Haematol 162, 74-86 ...
TranscriptionTranscription
Cancer-Prone Diseases (Inherited Cancer) and Genes involved in Cancer reviewed and published in the Atlas of Genetics and Cytogenetics in Oncology and Haematology
Hormone systemHormone system
Cancer-Prone Diseases (Inherited Cancer) and Genes involved in Cancer reviewed and published in the Atlas of Genetics and Cytogenetics in Oncology and Haematology
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bioind.com : Your Tissue Culture Partner - Biological Industries (BI)bioind.com : Your Tissue Culture Partner - Biological Industries (BI)
Over 30 years of experience in developibg and manufacturing diverse tissue culture portfolio, includes Sera, Media, Stem Cell Products, Cytogenetics, and more
บริษัท ซี เมดิค จำกัด | Quick Chaser Adeno / Quick Chaser Mycoบริษัท ซี เมดิค จำกัด | Quick Chaser Adeno / Quick Chaser Myco
สำนักงาน (สาขา) 592/260-261 หมู่บ้านอารียาโมวา, ถนนลาดปลาเค้า แขวงจรเข้บัว เขตลาดพร้าว กรุงเทพ 10230 ...
Medical geneticsMedical genetics
MarmosetMarmoset
Lalji SinghLalji Singh
Sequential hermaphroditismSequential hermaphroditism
Chimera (genetics)Chimera (genetics)
FreemartinFreemartin
Genome diversity and karyotype evolution of mammalsGenome diversity and karyotype evolution of mammals
Outline of medicineOutline of medicine
Barbara McClintockBarbara McClintock
ArrhenotokyArrhenotoky
DolichoderinaeDolichoderinae
IsodisomyIsodisomy
Calisto herophileCalisto herophile
Muriel DavissonMuriel Davisson
Tsing-ling pikaTsing-ling pika
Azteca (genus)Azteca (genus)
List of ant subfamiliesList of ant subfamilies
49,XXXXX49,XXXXX
Zika feverZika fever
Patagonian Leaf-eared MousePatagonian Leaf-eared Mouse
List of organisms by chromosome countList of organisms by chromosome count
Marcus Morton RhoadesMarcus Morton Rhoades
OphioglossumOphioglossum
ParthenogenesisParthenogenesis
Aporrectodea roseaAporrectodea rosea
NeocentromereNeocentromere
Pink-tailed worm-lizardPink-tailed worm-lizard
Auca cocteiAuca coctei
Trisomic rescueTrisomic rescue
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
CytogeneticsCytogenetic AnalysisChromosome AberrationsKaryotypingIn Situ Hybridization, FluorescenceLeukemia, Myeloid, AcuteTranslocation, GeneticMyelodysplastic SyndromesChromosome BandingLeukemia, MyeloidChromosome DisordersChromosome PaintingInterphaseMonosomyAbnormal KaryotypeTrisomyAneuploidyPrognosisKaryotypeRemission Inductionfms-Like Tyrosine Kinase 3Chromosomes, HumanLeukemia, Myelomonocytic, AcuteChromosomes, Human, Pair 11Chromosome DeletionChromosomes, Human, Pair 8Acute DiseaseMetaphaseNeoplasms, Adipose TissueChromosomes, Human, Pair 13Chromosome InversionChromosomes, Human, Pair 14Chromosomes, Human, Pair 5Chromosomes, Human, Pair 18Chromosomes, Human, Pair 15Gene RearrangementCytarabineBone MarrowChromosomes, Human, Pair 7Anemia, Refractory, with Excess of BlastsMultiple MyelomaImmunophenotypingSurvival AnalysisDisease-Free SurvivalChromosomes, Human, Pair 17Spectral KaryotypingChromosomes, Human, Pair 16Precursor Cell Lymphoblastic Leukemia-LymphomaNeoplasm, ResidualDNA ProbesLeukemia, Lymphocytic, Chronic, B-CellTreatment OutcomeChromosomes, Human, Pair 21Tandem Repeat SequencesPloidiesSurvival RateOncogene Proteins, FusionChromosomes, Human, Pair 1Philadelphia ChromosomeHematopoietic Stem Cell TransplantationChromosomes, Human, Pair 3DaunorubicinLaurence-Moon SyndromeNucleic Acid HybridizationOrthopteraChromosome BreakageChromosomes, Human, Pair 2DigoxigeninTransplantation, HomologousAntineoplastic Combined Chemotherapy ProtocolsIsochromosomesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveIdarubicinBlast CrisisLeukemia, Promyelocytic, AcutePrenatal DiagnosisChromosomesRecurrenceChromosomes, Human, Pair 9Hematologic DiseasesChromosomes, Human, Pair 12MutationChromosomes, Human, Pair 20Life TablesChromosomes, Human, XY ChromosomeChromosomes, Human, Pair 22Retrospective StudiesRing ChromosomesLeukemia, Myelomonocytic, ChronicDNA, NeoplasmGene DuplicationComparative Genomic HybridizationPolymerase Chain ReactionTransplantation, AutologousChromosomes, Human, Pair 4Abnormalities, MultipleFlow CytometrySex Chromosome AberrationsGene Expression Regulation, LeukemicThalidomideChromosomes, Artificial, BacterialMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsGenetic MarkersBone Marrow TransplantationChromosome MappingIntellectual DisabilityTurner SyndromeCore Binding Factor Alpha 2 SubunitSplenic NeoplasmsChromosomes, Human, Pair 10LeukemiaMultivariate AnalysisMosaicismNeoplasms, Second PrimaryBone Marrow ExaminationGenetic TechniquesBone Marrow CellsTumor Markers, BiologicalStem Cell TransplantationGene DeletionCytodiagnosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaImmunoglobulin Heavy ChainsFusion Proteins, bcr-ablTransplantation ConditioningParaffin EmbeddingOligonucleotide Array Sequence AnalysisChromosomes, Human, Pair 19X ChromosomeKaplan-Meier EstimateReverse Transcriptase Polymerase Chain ReactionAntineoplastic AgentsRisk FactorsMitotic IndexNuclear ProteinsDNA Copy Number VariationsCombined Modality TherapyChromosomal InstabilityLeukocyte CountAnemia, AplasticFalse Negative ReactionsDNA, SatelliteChromosomes, PlantVidarabineAntigens, CD34Follow-Up StudiesLymphoma, Non-HodgkinPolyploidySensitivity and SpecificityDNA Mutational AnalysisBusulfanGene Expression ProfilingHematologic NeoplasmsPhenotypeEvaluation Studies as TopicLymphoma, B-CellGene AmplificationAge FactorsInfant, NewbornProspective StudiesCentromereLymphomaAzacitidineCohort StudiesSalvage TherapyGene DosageDown SyndromeProto-Oncogene ProteinsSyndromeIn Situ HybridizationAntimetabolites, AntineoplasticHodgkin DiseaseChimeraLoss of Heterozygosity
Cytogenetics GalleryCytogenetics Gallery
20 Best Cytogenetics Tech jobs (Hiring Now!) | Simply Hired20 Best Cytogenetics Tech jobs (Hiring Now!) | Simply Hired
Definition of CytogeneticsDefinition of Cytogenetics
Cancer Cytogenetics SolutionsCancer Cytogenetics Solutions
Global Molecular Cytogenetics Market 2014-2018Global Molecular Cytogenetics Market 2014-2018
Cell Culture - Cytogenetics Core - Mayo Clinic ResearchCell Culture - Cytogenetics Core - Mayo Clinic Research
Dr. Eugene Pergament, MD - Chicago, IL - Clinical Genetics & Clinical Cytogenetics | Healthgrades.comDr. Eugene Pergament, MD - Chicago, IL - Clinical Genetics & Clinical Cytogenetics | Healthgrades.com
Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507
Molecular Cytogenetics Market worth 2.52 Billion USD by 2021Molecular Cytogenetics Market worth 2.52 Billion USD by 2021
Citation Machine: Molecular Cytogenetics format citation generator for congressional publicationCitation Machine: Molecular Cytogenetics format citation generator for congressional publication
Molecular Cytogenetics Market Size & Share | Industry Report, 2022Molecular Cytogenetics Market Size & Share | Industry Report, 2022
Molecular Cytogenetics Market Will Grow Rapidly Owing To Rising Incidence Of Congenital And Genetic Disorders Till 2022: Grand...Molecular Cytogenetics Market Will Grow Rapidly Owing To Rising Incidence Of Congenital And Genetic Disorders Till 2022: Grand...
Molecular Cytogenetics Market - Global Industry Analysis, Size and Forecast, 2016 to 2026Molecular Cytogenetics Market - Global Industry Analysis, Size and Forecast, 2016 to 2026
KAKEN - Research Projects | Studies on characteristics of molecular cytogenetics and demography in certain endangered plant...KAKEN - Research Projects | Studies on characteristics of molecular cytogenetics and demography in certain endangered plant...
Molecular Cytogenetics | MutagenesisMolecular Cytogenetics | Mutagenesis
Microarray with Karyotype (20 cell Analysis): CytogeneticsMicroarray with Karyotype (20 cell Analysis): Cytogenetics
Fish CytogeneticsFish Cytogenetics
Biphenotypic Acute Leukaemia (BAL)Biphenotypic Acute Leukaemia (BAL)
IRF4 (interferon regulatory factor 4)IRF4 (interferon regulatory factor 4)
Cancer Cytogenetics | SpringerLinkCancer Cytogenetics | SpringerLink
Cytogenetics - WikipediaCytogenetics - Wikipedia
Cytogenetics LaboratoryCytogenetics Laboratory
Molecular Cytogenetics - WikipediaMolecular Cytogenetics - Wikipedia
Comparative Cytogenetics - WikipediaComparative Cytogenetics - Wikipedia
Cytogenetics.Cytogenetics.
Cytogenetics of the Scilla scilloides complex | SpringerLinkCytogenetics of the Scilla scilloides complex | SpringerLink
Molecular Cytogenetics and Genome Organization - Pat Heslop-HarrisonMolecular Cytogenetics and Genome Organization - Pat Heslop-Harrison
Molecular Cytogenetics and Genome Organization - Pat Heslop-HarrisonMolecular Cytogenetics and Genome Organization - Pat Heslop-Harrison
Molecular Genetics and Cytogenetics in CancerMolecular Genetics and Cytogenetics in Cancer
PLNT3140 Introductory Cytogenetics - PCRPLNT3140 Introductory Cytogenetics - PCR
Plant breeding and cytogenetics by Fred C. Elliott | LibraryThingPlant breeding and cytogenetics by Fred C. Elliott | LibraryThing
Plant Cytogenetics - Methods and Protocols | Shahryar F. Kianian | SpringerPlant Cytogenetics - Methods and Protocols | Shahryar F. Kianian | Springer
Comparative Cytogenetics of Seven Ctenidae Species (Araneae)Comparative Cytogenetics of Seven Ctenidae Species (Araneae)
Tissue Cell Culture, Cytogenetics LabTissue Cell Culture, Cytogenetics Lab
What Is Cytogenetics? (with pictures)What Is Cytogenetics? (with pictures)
A systems biology perspective on molecular cytogenetics | EurekAlert! Science NewsA systems biology perspective on molecular cytogenetics | EurekAlert! Science News
cytogeneticscytogenetics
Amniotic Fluid Cell Culture, Cytogenetics LabAmniotic Fluid Cell Culture, Cytogenetics Lab
Cytogenetics, High Resolution & Fragile X DNACytogenetics, High Resolution & Fragile X DNA
Cytogenetics sub-cluster 74Cytogenetics sub-cluster 74
Cytogenetics sub-cluster 37Cytogenetics sub-cluster 37
Global Cytogenetics Technologies, Companies and Markets to 2027 | BenzingaGlobal Cytogenetics Technologies, Companies and Markets to 2027 | Benzinga
Cytogenetics of Metastatic Uveal Melanoma - American Academy of OphthalmologyCytogenetics of Metastatic Uveal Melanoma - American Academy of Ophthalmology
Cytogenetics/Cytogenomics Laboratory | UC San Diego HealthCytogenetics/Cytogenomics Laboratory | UC San Diego Health
Cytogenetics | Thermo Fisher Scientific - USCytogenetics | Thermo Fisher Scientific - US
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
CytogeneticsCytogenetic AnalysisChromosome AberrationsKaryotypingIn Situ Hybridization, FluorescenceLeukemia, Myeloid, AcuteTranslocation, GeneticMyelodysplastic SyndromesChromosome BandingLeukemia, MyeloidChromosome DisordersChromosome PaintingInterphaseMonosomyAbnormal KaryotypeTrisomyAneuploidyPrognosisKaryotypeRemission Inductionfms-Like Tyrosine Kinase 3Chromosomes, HumanLeukemia, Myelomonocytic, AcuteChromosomes, Human, Pair 11Chromosome DeletionChromosomes, Human, Pair 8Acute DiseaseMetaphaseNeoplasms, Adipose TissueChromosomes, Human, Pair 13Chromosome InversionChromosomes, Human, Pair 14Chromosomes, Human, Pair 5Chromosomes, Human, Pair 18Chromosomes, Human, Pair 15Gene RearrangementCytarabineBone MarrowChromosomes, Human, Pair 7Anemia, Refractory, with Excess of BlastsMultiple MyelomaImmunophenotypingSurvival AnalysisDisease-Free SurvivalChromosomes, Human, Pair 17Spectral KaryotypingChromosomes, Human, Pair 16Precursor Cell Lymphoblastic Leukemia-LymphomaNeoplasm, ResidualDNA ProbesLeukemia, Lymphocytic, Chronic, B-CellTreatment OutcomeChromosomes, Human, Pair 21Tandem Repeat SequencesPloidiesSurvival RateOncogene Proteins, FusionChromosomes, Human, Pair 1Philadelphia ChromosomeHematopoietic Stem Cell TransplantationChromosomes, Human, Pair 3DaunorubicinLaurence-Moon SyndromeNucleic Acid HybridizationOrthopteraChromosome BreakageChromosomes, Human, Pair 2DigoxigeninTransplantation, HomologousAntineoplastic Combined Chemotherapy ProtocolsIsochromosomesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveIdarubicinBlast CrisisLeukemia, Promyelocytic, AcutePrenatal DiagnosisChromosomesRecurrenceChromosomes, Human, Pair 9Hematologic DiseasesChromosomes, Human, Pair 12MutationChromosomes, Human, Pair 20Life TablesChromosomes, Human, XY ChromosomeChromosomes, Human, Pair 22Retrospective StudiesRing ChromosomesLeukemia, Myelomonocytic, ChronicDNA, NeoplasmGene DuplicationComparative Genomic HybridizationPolymerase Chain ReactionTransplantation, AutologousChromosomes, Human, Pair 4Abnormalities, MultipleFlow CytometrySex Chromosome AberrationsGene Expression Regulation, LeukemicThalidomideChromosomes, Artificial, BacterialMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsGenetic MarkersBone Marrow TransplantationChromosome MappingIntellectual DisabilityTurner SyndromeCore Binding Factor Alpha 2 SubunitSplenic NeoplasmsChromosomes, Human, Pair 10LeukemiaMultivariate AnalysisMosaicismNeoplasms, Second PrimaryBone Marrow ExaminationGenetic TechniquesBone Marrow CellsTumor Markers, BiologicalStem Cell TransplantationGene DeletionCytodiagnosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaImmunoglobulin Heavy ChainsFusion Proteins, bcr-ablTransplantation ConditioningParaffin EmbeddingOligonucleotide Array Sequence AnalysisChromosomes, Human, Pair 19X ChromosomeKaplan-Meier EstimateReverse Transcriptase Polymerase Chain ReactionAntineoplastic AgentsRisk FactorsMitotic IndexNuclear ProteinsDNA Copy Number VariationsCombined Modality TherapyChromosomal InstabilityLeukocyte CountAnemia, AplasticFalse Negative ReactionsDNA, SatelliteChromosomes, PlantVidarabineAntigens, CD34Follow-Up StudiesLymphoma, Non-HodgkinPolyploidySensitivity and SpecificityDNA Mutational AnalysisBusulfanGene Expression ProfilingHematologic NeoplasmsPhenotypeEvaluation Studies as TopicLymphoma, B-CellGene AmplificationAge FactorsInfant, NewbornProspective StudiesCentromereLymphomaAzacitidineCohort StudiesSalvage TherapyGene DosageDown SyndromeProto-Oncogene ProteinsSyndromeIn Situ HybridizationAntimetabolites, AntineoplasticHodgkin DiseaseChimeraLoss of Heterozygosity
Global molecular2016LaboratoryFluorescence in situ hybriChromosomesAssessApproachesAdvancesChromosomalExpected to boMolecular biology2022RevenuePlantResearchStudyPersonalized MedicineCellBloodJobsBoardLaboratoryFluorescenceField of cytogeneticsFluorescent in situ hybriImpacting the molecular cytogenetics marketOverall molecular cytogenetics marketClinicalInterphaseGenomeNorth AmericaAnimal cytogeneticsComprehensive cytogeneticsGenomicsMethodsBiomarkersConventionalCytogenomicsHeslop-HarrisonLaboratoriesCell GeneticsPlantDetectionAnalysesSingle moleculeGenetic disordersDiagnosticACGHPRNewswireMarketsServices
Global molecular13
20161
Laboratory3
  • Duties for a Laboratory Technician in the UMHS Clinical Cytogenetics Laboratory consist primarily of lab bench responsibilities but may also include clerical. (simplyhired.com)
  • May perform laboratory bench testing procedures involved in the pre-analytic steps of Cytogenetics and FISH following appropriate training Additional duties as. (simplyhired.com)
  • The Cytogenetics Director will be responsible for the management of technical and scientific operation within an assigned clinical Cytogenetics and FISH Laboratory department, including accurate reporting of patient results, case review, and reviewing validation data. (workinaz.jobs)
Fluorescence in situ hybri2
Chromosomes2
Assess1
Approaches1
Advances2
Chromosomal3
Expected to bo1
Molecular biology1
20221
Revenue1
Plant2
  • Plant cytogenetics has progressed at a rapid rate since the publication of the first edition. (ebooks.com)
  • Plant Cytogenetics, Second Edition presents an up-to-date review of cytogenetics. (ebooks.com)
Research2
Study2
Personalized Medicine1
Cell1
Blood1
  • If the sample has been collected, please place a "Cytogenetics Postnatal (blood)" order--LAB5505A. (uncmedicalcenter.org)
Jobs1
Board1
Laboratory24
Fluorescence4
Field of cytogenetics4
  • Cutting edge and thorough, Plant Cytogenetics: Methods and Protocols, is a valuable resource for anyone who is interested in the diverse and wonderfully complex field of cytogenetics. (springer.com)
  • The author's aim on writing the present work is to outline and reunite some facts and investigations made latterly in the field of Cytogenetics which are the basis for the development of new breeding techniques and methods. (csic.es)
  • After earning your master's degree, you'll be able to enroll in a Ph.D. program and pursue an academic career leading research projects and making contributions to the scientific literature in the field of cytogenetics. (study.com)
  • PerkinElmer's global experience in the genetic screening market and expertise in the field of cytogenetics is an ideal match for Roche NimbleGen's innovative array technologies. (roche.com)
Fluorescent in situ hybri2
Impacting the molecular cytogenetics market1
Overall molecular cytogenetics market1
Clinical7
Interphase1
Genome6
North America5
Animal cytogenetics1
Comprehensive cytogenetics2
  • We provide a comprehensive cytogenetics service for the investigation of constitutional chromosome abnormalities. (stgeorges.nhs.uk)
  • This is a further evolution of the relationship between the two companies which started in 2009 with the development of a comprehensive cytogenetics array workflow. (roche.com)
Genomics2
Methods3
  • The methods described in Plant Cytogenetics: Methods and Protocols build on each other and provide, those new to the field, with a comprehensive platform to support their research endeavours, while also introducing advanced techniques to experienced researchers. (springer.com)
  • Surprisingly, there is very little research capacity in New Zealand for cytogenetics, so Prashant will become the resident national expert in these methods," Dr Tate says. (massey.ac.nz)
  • This breadth of coverage, together with the inclusion of methods and instruction, is intended to convey a deep and useful appreciation for plant cytogenetics. (nhbs.com)
Biomarkers1
Conventional1
Cytogenomics2
Heslop-Harrison1
Laboratories1
  • This collaboration provides cytogenetics laboratories an array workflow with robust data, a quick and easy workflow, and powerful analysis tools," stated Frank Pitzer, CEO of Roche NimbleGen. (roche.com)
Cell Genetics1
Plant4
Detection2
Analyses1
  • Cytogenetics, with its fundamental role in the field of genetic investigation, continues to be an indispensable tool for studying phylogenetics, given that currently molecular evolutionary analyses are more commonly utilized. (intechopen.com)
Single molecule1
Genetic disorders1
Diagnostic1
ACGH2
PRNewswire1
  • Logo: http://photos.prnewswire.com/prnh/2013...This report deals with cytogenetics in a broader sense rather than the. (bio-medicine.org)
Markets2
  • The 'Cytogenetics - Technologies, Markets and Companies' report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering. (benzinga.com)
  • EIN News / -- Dublin, May 21, 2019 (GLOBE NEWSWIRE) -- The "Cytogenetics - Technologies, Markets & Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering. (einpresswire.com)
Services2
  • Cytogenetics Core cell culture services include setup, culturing, harvesting, slide preparation and slow freezing. (mayo.edu)
  • In July 2002, Waisman Center Cytogenetics and WSLH Cytogenetics merged to form UW Cytogenetic Services (UWCS). (wisc.edu)
Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507
Plant Cytogenetics, Second Edition (ebook) by Ram J. Singh | 9781420038507 (ebooks.com)
Cytogenetics | Protocol (Translated to German)
Cytogenetics | Protocol (Translated to German) (jove.com)
Case 613 -- Cytogenetics - Pathology Case
Case 613 -- Cytogenetics - Pathology Case (path.upmc.edu)
Fern - The sorus | Britannica.com
Fern - The sorus | Britannica.com (britannica.com)
Plant Cytogenetics - Methods and Protocols | Shahryar F. Kianian | Springer
Plant Cytogenetics - Methods and Protocols | Shahryar F. Kianian | Springer (springer.com)
Cancer Cytogenetics | SpringerLink
Cancer Cytogenetics | SpringerLink (link.springer.com)
Cytogenetics | Hope After Miscarriage
Cytogenetics | Hope After Miscarriage (hopeaftermiscarriage.com)
Molecular Cytogenetics and Genome Evolution: Pat Heslop-Harrison and Trude Schwarzacher, Leicester UK
Molecular Cytogenetics and Genome Evolution: Pat Heslop-Harrison and Trude Schwarzacher, Leicester UK (le.ac.uk)
UMass Medical School - Worcester
UMass Medical School - Worcester (umassmed.edu)
Acute Myeloid Leukemia Diagnosis
Acute Myeloid Leukemia Diagnosis (news-medical.net)
Systems Biology, Control, Robustness and Networks in Biology at University of Leicester
Systems Biology, Control, Robustness and Networks in Biology at University of Leicester (le.ac.uk)
Cytogenetics Laboratory
Cytogenetics Laboratory (massgeneral.org)
Everyday's An Adventure...Medical Technologist Magnet | Zazzle.co.uk
Everyday's An Adventure...Medical Technologist Magnet | Zazzle.co.uk (zazzle.co.uk)
Ploidy Reductions in Murine Fusion-Derived Hepatocytes
Ploidy Reductions in Murine Fusion-Derived Hepatocytes (journals.plos.org)
Cytogenetics of the Scilla scilloides complex | SpringerLink
Cytogenetics of the Scilla scilloides complex | SpringerLink (link.springer.com)
CHARLES MADERA RICK | Biographical Memoirs: Volume 84 | The National Academies Press
CHARLES MADERA RICK | Biographical Memoirs: Volume 84 | The National Academies Press (nap.edu)
Acute Lymphoblastic Leukemia (ALL) Workup: Approach Considerations, Routine Laboratory Studies, Radiologic Studies
Acute Lymphoblastic Leukemia (ALL) Workup: Approach Considerations, Routine Laboratory Studies, Radiologic Studies (emedicine.medscape.com)
Human Cytogenetics, Malignancy and Acquired Abnormalities by Denise Rooney | 9780199638420 | Booktopia
Human Cytogenetics, Malignancy and Acquired Abnormalities by Denise Rooney | 9780199638420 | Booktopia (booktopia.com.au)
A systems biology perspective on molecular cytogenetics | EurekAlert! Science News
A systems biology perspective on molecular cytogenetics | EurekAlert! Science News (eurekalert.org)
Cytogenetics, phylogeny and evolution of cultivated wheats - B.S. Gill, B. Friebe
Cytogenetics, phylogeny and evolution of cultivated wheats - B.S. Gill, B. Friebe (fao.org)
What Is Cytogenetics? (with pictures)
What Is Cytogenetics? (with pictures) (wisegeek.com)
Glossary of Terms | Aplastic Anemia & MDS International Foundation
Glossary of Terms | Aplastic Anemia & MDS International Foundation (aamds.org)
Fundamental Sciences - Massey University
Fundamental Sciences - Massey University (massey.ac.nz)
Frontiers | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |...
Frontiers | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |... (frontiersin.org)
Acute lymphoblastic leukemia - Wikipedia
Acute lymphoblastic leukemia - Wikipedia (en.m.wikipedia.org)
Industrial & Manufacturing|Medical & Science Jobs in Murray|Gaithersburg Kentucky|Maryland |Adecco USA
Industrial & Manufacturing|Medical & Science Jobs in Murray|Gaithersburg Kentucky|Maryland |Adecco USA (adeccousa.com)
Scientific equipment, experiments & techniques books and reviews. The best Scientific equipment, experiments & techniques books...
Scientific equipment, experiments & techniques books and reviews. The best Scientific equipment, experiments & techniques books... (lovereading.co.uk)
Cytogenetics of the squirrel monkey ( Saimiri sciureus) | SpringerLink
Cytogenetics of the squirrel monkey ( Saimiri sciureus) | SpringerLink (link.springer.com)
Tissue Cell Culture, Cytogenetics Lab
Tissue Cell Culture, Cytogenetics Lab (nationwidechildrens.org)
De novo chromosome 7q36.1q36.2 triplication in a child with developmental delay, growth failure, distinctive facial features,...
De novo chromosome 7q36.1q36.2 triplication in a child with developmental delay, growth failure, distinctive facial features,... (link.springer.com)
Cytogenetics Core Laboratory | City of Hope in Southern CA
Cytogenetics Core Laboratory | City of Hope in Southern CA (cityofhope.org)
What Defines an 'Elderly Patient With AML'?
What Defines an 'Elderly Patient With AML'? (cancernetwork.com)
Lab Test: Cancer Probe by DNA FISH | Akron Children's Hospital
Lab Test: Cancer Probe by DNA FISH | Akron Children's Hospital (akronchildrens.org)