Cystatin C: An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.Cystatins: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.Cystatin A: A cytastin subtype found at high levels in the SKIN and in BLOOD CELLS. Cystatin A incorporates into the cornified cell envelope of stratified squamous epithelial cells and may play a role in bacteriostatic properties of skin.Cystatin B: An intracellular cystatin subtype that is found in a broad variety of cell types. It is a cytosolic enzyme inhibitor that protects the cell against the proteolytic action of lysosomal enzymes such as CATHEPSINS.CreatinineGlomerular Filtration Rate: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.Salivary Cystatins: A group of closely-related cystatins found in SALIVA.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Kidney Function Tests: Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.Nephelometry and Turbidimetry: Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.Cerebrospinal Fluid Proteins: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)Cathepsin B: A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.Papain: A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.Cathepsins: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.Lipocalins: A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Cathepsin H: An ubiquitously-expressed lysosomal cysteine protease that is involved in protein processing. The enzyme has both endopeptidase and aminopeptidase activities.Cathepsin L: A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.Cerebral Amyloid Angiopathy: A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.ROC Curve: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.Protease Inhibitors: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.beta 2-Microglobulin: An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.Acute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Azotemia: A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Dependent Ambulation: To move about or walk on foot with the use of aids.Cysteine Proteases: A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity.Urine Specimen Collection: Methods or procedures used to obtain samples of URINE.Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.Amyloidosis, Familial: Diseases in which there is a familial pattern of AMYLOIDOSIS.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.Protein Array Analysis: Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Proteome: The protein complement of an organism coded for by its genome.

Intracellular accumulation of the amyloidogenic L68Q variant of human cystatin C in NIH/3T3 cells. (1/683)

AIM: To study the cellular transport of L68Q cystatin C, the cystatin variant causing amyloidosis and brain haemorrhage in patients suffering from hereditary cystatin C amyloid angiopathy (HCCAA). METHODS: Expression vectors for wild-type and L68Q cystatin C were constructed and used to transfect mouse NIH/3T3 cells. Stable cell clones were isolated after cotransfection with pSV2neo. Clones expressing human wild-type and L68Q cystatin C were compared with respect to secreted cystatin C by enzyme linked immunosorbent assay (ELISA), and for intracellular cystatin C by western blotting and immunofluorescence cytochemistry. Colocalisation studies in cells were performed by double staining with antibodies against human cystatin C and marker proteins for lysosomes, the Golgi apparatus, or the endoplasmic reticulum, and evaluated by confocal microscopy. RESULTS: Concentrations of human cystatin C secreted from transfected NIH/3T3 cells were similar to those secreted from human cells in culture. In general, clones expressing the gene encoding L68Q cystatin C secreted slightly lower amounts of the protein than clones expressing wild-type human cystatin C. Both immunofluorescence cytochemistry and western blotting experiments showed an increased accumulation of cystatin C in cells expressing the gene encoding L68Q cystatin C compared with cells expressing the gene for the wild-type protein. The intracellularly accumulating L68Q cystatin C was insoluble and located mainly in the endoplasmic reticulum. CONCLUSIONS: The cellular transport of human cystatin C is impeded by the pathogenic amino acid substitution Leu68-->Gln. The resulting intracellular accumulation and increased localised concentration of L68Q cystatin C might be an important event in the molecular pathophysiology of amyloid formation and brain haemorrhage in patients with HCCAA.  (+info)

The affinity and kinetics of inhibition of cysteine proteinases by intact recombinant bovine cystatin C. (2/683)

Recent studies have shown that the bovine cysteine proteinase inhibitor, cystatin C, is synthesized as a preprotein containing a 118-residue mature protein. However, the forms of the inhibitor isolated previously from bovine tissues had shorter N-terminal regions than expected from these results, and also lower affinity for proteinases than human cystatin C. In this work, we report the properties of recombinant, full-length bovine cystatin C having a complete N-terminal region. The general characteristics of this form of the inhibitor, as reflected by the isoelectric point, the far-ultraviolet circular dichroism spectrum, the thermal stability and the changes of tryptophan fluorescence on interaction with papain, resembled those of human cystatin C. The affinity and kinetics of inhibition of papain and cathepsins B, H and L by the bovine inhibitor were also comparable with those of the human inhibitor, although certain differences were apparent. Notably, the affinity of bovine cystatin C for cathepsin H was somewhat weaker than that of human cystatin C, and bovine cystatin C bound to cathepsin L with about a four-fold higher association rate constant than the human inhibitor. This rate constant is comparable with the highest values reported previously for cystatin-cysteine proteinase reactions. The full-length, recombinant bovine cystatin C bound appreciably more tightly to proteinases than the shorter form characterized previously. Digestion of the recombinant inhibitor with neutrophil elastase resulted in forms with truncated N-terminal regions and appreciably decreased affinity for papain, consistent with the forms of bovine cystatin C isolated previously having arisen by proteolytic cleavage of a mature, full-length inhibitor.  (+info)

Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. (3/683)

We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C. The cystatin was seen to inhibit enzyme activity by stoichiometric 1:1 binding in competition with substrate. The Ki value for the interaction was 0.20 nM, i.e. cystatin C had an affinity for legumain similar to that for the papain-like family C1 cysteine peptidase, cathepsin B. However, cystatin C variants with alterations in the N-terminal region and the "second hairpin loop" that rendered the cystatin inactive against cathepsin B, still inhibited legumain with Ki values 0.2-0.3 nM. Complexes between cystatin C and papain inhibited legumain activity against benzoyl-Asn-NHPhNO2 as efficiently as did cystatin C alone. Conversely, cystatin C inhibited papain activity against benzoyl-Arg-NHPhNO2 whether or not the cystatin had been incubated with legumain, strongly indicating that the cystatin inhibited the two enzymes with non-overlapping sites. A ternary complex between legumain, cystatin C, and papain was demonstrated by gel filtration supported by immunoblotting. Screening of a panel of cystatin superfamily members showed that type 1 inhibitors (cystatins A and B) and low Mr kininogen (type 3) did not inhibit pig legumain. Of human type 2 cystatins, cystatin D was non-inhibitory, whereas cystatin E/M and cystatin F displayed strong (Ki 0.0016 nM) and relatively weak (Ki 10 nM) affinity for legumain, respectively. Sequence alignments and molecular modeling led to the suggestion that a loop located on the opposite side to the papain-binding surface, between the alpha-helix and the first strand of the main beta-pleated sheet of the cystatin structure, could be involved in legumain binding. This was corroborated by analysis of a cystatin C variant with substitution of the Asn39 residue in this loop (N39K-cystatin C); this variant showed a slight reduction in affinity for cathepsin B (Ki 1.5 nM) but >>5,000-fold lower affinity for legumain (Ki >>1,000 nM) than wild-type cystatin C.  (+info)

Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids. (4/683)

Cystatin C with the 11 N-terminal amino acids truncated shows a much lower affinity for cysteine proteinases than the intact inhibitor. Such truncation of cystatin C is recorded after action of glycyl endopeptidase and cathepsin L. Incubation of cystatin C with papain, cathepsin B or cathepsin H led to no changes in the cystatin C molecule. Isoelectric focusing of the cathepsin L and cystatin C mixture showed the formation of two new bands. One of them appeared whether E-64 or PMSF was added or not, evidently representing a cystatin C/cathepsin L complex. The other band is the truncated cystatin C molecule. N-terminal sequencing after separation by HPLC showed that cystatin C is cleaved by cathepsin L at the Gly11-Gly12 bond. The action of cathepsin L on cystatin C may be explained by the cleavage of the scissile bond in an inappropriate complex.  (+info)

Rapid and accurate assessment of glomerular filtration rate in patients with renal transplants using serum cystatin C. (5/683)

BACKGROUND: Assessment of renal function in patients with renal transplants is of great importance. Various studies have reported cystatin C as an easily and rapidly assessable marker that can be used for accurate information on renal function impairment. To date, no study is available to define the role of cystatin C in patients with renal transplants. METHODS: Thirty steady-state patients (50% male/50% female) with status post-kidney transplantation were studied. To assess renal function, cystatin C, creatinine clearance, serum creatinine, beta2-microglobulin (beta2M), and [125I]iothalamate clearance were determined. Correlations and non-parametric ROC curves for accuracy, using a cut-off glomerular filtration rate (GFR) of 60 ml/min, were obtained for the different markers allowing for calculations of positive predictive values (PPV), positive likelihood ratios (PLR), specificity and sensitivity, respectively. Further, to evaluate the usefulness of these markers for monitoring, intraindividual coefficients of variation (CVs) for cystatin C and creatinine measurements were compared in 85 renal transplant patients. Measurements consisted of at least six pairs of results, which were obtained at different time points during routine follow-up. RESULTS: Cystatin C correlated best with GFR (r=0.83), whereas serum creatinine (r=0.67), creatinine clearance (r=0.57) and beta2M (r=0.58) all had lower correlation coefficients. The diagnostic accuracy of cystatin C was significantly better than serum creatinine (P=0.025), but did not differ significantly from creatinine clearance (P=0.76) and beta2M (P=0.43). At a cut-off of 1.64 mg/l, cystatin C has a PPV of 93%, PLR of 6.4, specificity 89% and sensitivity 70%, respectively. For beta2M, PPV 83%, PLR 1.7, specificity 67% and sensitivity 75% was seen at a cut-off of 3.57 mg/l. Accordingly, at a cut-off of 125 micromol/l for serum creatinine, a PPV 76%, PLR 1.4, specificity 44% and sensitivity 80% was revealed. Finally, at a cut-off of 66 ml/min/1.73 m2 for creatinine clearance, the following characteristics were found: PPV 94%, PLR 7.7, specificity 89% and sensitivity 85%. The intraindividual variation of creatinine was significantly lower than that of cystatin C (P<0.001). With increasing concentrations, their ratios of CV tended towards a value of 1, demonstrating identical variability at low GFR. CONCLUSION: Together, our data show that in patients with renal transplants, cystatin C, in terms of PPV and PLR, has a similar diagnostic value as creatinine clearance. However, it is superior to serum determinations of creatinine and beta2M. The intraindividual variation of cystatin C is greater than that of creatinine. This might be due to the better ability of cystatin C to reflect temporary changes especially in mildly impaired GFR, most critical for early detection of rejection and other function impairment. Thus, cystatin C allows for rapid and accurate assessment of renal function (GFR) in renal transplants and is clearly superior to the commonly used serum creatinine.  (+info)

High-dose aprotinin with gentamicin-vancomycin antibiotic prophylaxis increases blood concentrations of creatinine and cystatin C in patients undergoing coronary artery bypass grafting. (6/683)

Both aprotinin and gentamicin-vancomycin antibiotic prophylaxis have been used widely in cardiac surgery to prevent bleeding and infections, respectively. As the drugs are excreted almost entirely by glomerular filtration, we investigated their action on renal function when administered either separately or together. To increase consistency, we measured serum concentrations of creatinine and cystatin C, a new marker of glomerular filtration rate, that many recent studies have shown to be more sensitive than serum creatinine. One hundred patients undergoing coronary artery bypass surgery were allocated randomly to one of four groups: group A received antibiotic prophylaxis with cefamandole and no aprotinin; group B received cefamandole and high-dose aprotinin; group C received antibiotic prophylaxis with gentamicin and vancomycin, but no aprotinin; and group D received both high-dose aprotinin and gentamicin-vancomycin antibiotic prophylaxis. Data from 84 patients, for whom data collection was complete, were analysed. In the first week after operation, mean serum concentrations of cystatin C and creatinine either remained constant or decreased slowly in all groups, except for group D. In group D, both markers increased gradually from postoperative day 2 onwards. The increase in cystatin C was significant on postoperative day 5 (from mean 1.02 (SD 0.11) mg litre-1 before operation to 1.35 (0.32) mg litre-1; P < 0.05), reaching a peak on postoperative day 7 (1.45 (0.35) mg litre-1; P < 0.05), while the increase in creatinine concentration was significant on postoperative day 6 (from 1.05 (0.16) mg dl-1 before operation to 1.29 (0.34) mg dl-1; P < 0.05). We conclude that simultaneous administration of high-dose aprotinin and prophylactic use of gentamicin with vancomycin increased serum concentrations of cystatin C and creatinine in the first postoperative week in patients undergoing cardiac surgery.  (+info)

Cystatin C as a determinant of fasting plasma total homocysteine levels in coronary artery disease patients with normal serum creatinine. (7/683)

Serum creatinine, a surrogate for both renal function and homocysteine generation, is a determinant of fasting plasma total homocysteine levels in coronary artery disease (CAD) patients. We hypothesized that among stable-CAD patients with normal creatinine levels (ie, 0.2). Consistent with the impact of folic acid fortification of cereal grain flour in the general population, only 1 of the CAD subjects (0.6%) had a plasma folate level <3 ng/mL. We conclude that serum cystatin C levels may reflect subtle decreases in renal function that independently predict fasting total homocysteine levels among stable-CAD patients with normal serum creatinine.  (+info)

Cystatin C deficiency in human atherosclerosis and aortic aneurysms. (8/683)

The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin damage, but whether endogenous local inhibitors counterbalance these proteases is unknown. We show here that, whereas cystatin C is normally expressed in vascular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely reduced in both atherosclerotic and aneurysmal aortic lesions. Furthermore, increased abdominal aortic diameter among 122 patients screened by ultrasonography correlated inversely with serum cystatin C levels. In vitro, cytokine-stimulated vascular SMCs secrete cathepsins, whose elastolytic activity could be blocked when cystatin C secretion was induced by treatment with TGF-beta(1). The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease.  (+info)

Introduction: Plasma cystatin C is independently associated with cardiovascular (CV) risk in non-ST-elevation acute coronary syndromes (NSTE-ACS). The effect of genetic variability on cystatin C concentrations and outcome is unclear.. Methods: Plasma cystatin C concentrations were measured in blood, obtained within 24 hours of admission, in 16279 ACS patients from the PLATelet inhibition and patient Outcomes trial. 9978 patients were genome-wide genotyped with up to 2.5 million SNPs. The first occurrence of CV death or myocardial infarction (MI) within one year was evaluated by multivariable (clinical variables and biomarkers) Cox regression analysis and c-statistics both overall (all ACS) and in NSTE-ACS.. Results: We observed SNP association with cystatin C levels (up to p=7.82 x 10-16). The most significant SNP (rs6048952) was adjacent the CST3 gene with additive effect on cystatin C concentrations: 0.85mg/L, 0.80mg/L and 0.73mg/L for the A/A, A/G and G/G genotypes respectively. Multivariable ...
FRIDAY, Sept. 22, 2017 (HealthDay News) - Serum cystatin C level is an excellent predictor of mortality in patients with cirrhotic ascites, according to a study published online Sept. 14 in the Journal of Gastroenterology and Hepatology.. Yeon Seok Seo, M.D., Ph.D., from the Korea University College of Medicine in Seoul, South Korea, and colleagues prospectively enrolled 350 patients with cirrhotic ascites (mean age, 55.4 years; 76.3 percent male) from 15 hospitals (September 2009 through March 2013). The authors sought to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites.. The researchers found that serum creatinine and cystatin C levels were 0.9 and 1.1 mg/L, respectively. International normalized ratio (INR) and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality, in multivariate analyses, while INR and serum sodium and cystatin C levels were independent predictors of the development of type 1 hepatorenal syndrome ...
Background: The L68Q variant of cystatin C is highly amyloidogenic forming aggregates in individuals with HCCAA. Results: Spermatozoa from mice expressing human L68Q cystatin C exhibit fertility defects and increased levels of amyloid. Conclusion: L68Q epididymal fluid containing cystatin C amyloid is harmful for sperm function. Significance: Amyloid in the reproductive tract may contribute to male factor infertility. Hereditary cystatin C amyloid angiopathy is an autosomal dominant disorder in which a variant form of cystatin C (L68Q) readily forms amyloid deposits in cerebral arteries in affected individuals resulting in early death. L68Q protein deposits in human cystatin C amyloid angiopathy patients have also been found in tissues outside of the brain including the testis, suggesting possible effects on fertility. Heterozygous transgenic mice (L68Q) that express the human L68Q variant of cystatin C under the control of the mouse cystatin C promoter were unable to generate offspring, ...
The median cystatin C value was 0.83 mg/L. Increasing quartiles of cystatin C were strongly associated with death and MI (6.9%, 7.1%, 9.5%, and 16.2%). The fully adjusted hazard ratios per standard deviation of cystatin C in the non-ST-segment elevation (NSTE)-ACS and STE-ACS populations were 1.12 (95% confidence interval [CI], 1.04-1.20) (n = 8,053) and 1.06 (95% CI, 0.97-1.17) (n = 5,278), respectively. However, the overall C-statistics for the different renal function measurements were minimally different, ranging from 0.6923 (cystatin C) to 0.6941 (CKD-EPI). Neither cystatin C nor other creatinine-based equations increased the area under the curve compared to a model that did not include a renal marker. The benefit of ticagrelor tended to be greater with higher levels of cystatin C.. ...
We found that higher cystatin C concentrations showed a greater association with severe CMB pathology especially in patients of the highest quartile. One standard deviation increase in the log-transformation of cystatin C levels also showed a closer relationship with severe CMBs. The estimated GFR and microalbumin/creatinine ratio failed to show a significant association with the number of CMBs. Moreover, the association was sustained in patients with deep or infratentorial CMBs but not among those with strictly lobar CMBs. In addition, the correlation between the CMB grades and cystatin C in patients with lacunar stroke showed a stronger association than that in patients with non lacunar stroke. Cystatin C was the most powerful indicator for CMBs among the three renal markers. Our results corroborate previous studies showing that renal dysfunction is independently associated with CMBs [8, 29]. Furthermore, we showed that cystatin C may reflect the severity of CMBs in a dose dependent manner ...
Renal dysfunction is associated with increased cardiovascular morbidity and mortality. The aim of this cross-sectional study was to investigate the relationship between the glomerular filtration marker cystatin C and other cardiovascular risk markers and morbidity in elderly males. Cystatin C was measured in a group of 77-year-old males (n=792) and compared cystatin C with other known risk markers for cardiovascular disease. Cystatin C values were significantly increased in individuals with diabetes (p=0.05) and cardiovascular diseases (p,0.0001). There were significant correlations between cystatin C values and body mass index, HbA1c, insulin, triglycerides and hsCRP.. ...
Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine. Methods. A case-control study of 57 women diagnosed with pre-eclampsia, and 218 healthy women with uncomplicated singleton pregnancies in the third trimester. Women in the catchment area of Lund, Sweden, were included during an 18-month period from October 2003 to April 2005. Venous blood samples were drawn ...
BACKGROUND: Human cystatin C is a cysteine protease inhibitor produced by all nucleated cells in the body and the protein is present in all body fluids. The concentration in cerebrospinal fluid (CSF) is considerably higher than in plasma. Cystatin C levels seem to influence the development of Alzheimer disease (AD) and low levels in the brain are associated with an increased risk for AD. The aim of this study was to develop a high throughput assay for the quantification of cystatin C in CSF. METHODS: Antigen excess, imprecision, interference, linearity, recovery, sample stability and reference values were evaluated on Architect ci8200 (Abbott Laboratories, Abbott Park, IL, USA). RESULTS: The assay had an antigen-excess limit at 23 mg/L and was linear over the range of 0.84 to 8.33 mg/L. Results , 8.33 mg/L were automatically rerun in a higher dilution. Within-run coefficient of variation (CV) was 1.71, 1.10 and 0.79%, between day CV was 1.71, 0.39 and 1.45%, between-run CV was 0.58, 0.66 and ...
en] Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86 ...
4) Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia.. Address for correspondence: O.N. Poteryaeva, Russian Academy of Medical Sciences, Institute of Physiology, Novosibirsk, Russia.. Summary: Cystatin C is the best known extracellular endogenous cysteine proteinase inhibitor and has been studied as a possible index of tumor growth and as a marker of the effectiveness of antitumor therapy. The aim of this study was to evaluate cystatin C concentrations in murine tumor tissues (compared with other organs not directly involved with tumor development, such as the liver and spleen) during treatment with several antitumor drugs (Ukrain and/or cyclophosphane). Cystatin C concentrations in murine tissues and biological fluids was determined by enzyme-linked immunosorbent (ELISA) assay The cystatin C ELISA test is a sandwich immunoassay, which uses immobilized rabbit antihuman cystatin C Pab and mouse antihuman cystatin C Mab-HRP (monoclonal antibodies, conjugated with horseradish ...
Background: There is limited data regarding the clinical utility of cystatin C in patients with stable coronary artery disease (CAD). The aim of this study was to determine the predictive value of cystatin C for the presence and severity of CAD and the association between this protein and other biochemical risk factors for atherosclerosis in patients with suspected CAD. ...
Methods Cross-sectional analysis of 5386 participants from The Irish Longitudinal Study on Ageing, a cluster-sampled national cohort of community-dwelling adults aged ≥50 years. Cystatin C and creatinine were measured simultaneously using standardised assays. Using generalised additive models, we modelled the distributions of creatinine and cystatin C per year of age from four distributional parameters: location, dispersion, skewness, kurtosis. Among participants with CKD stage 3a, we estimated the predicted probability of cystatin C eGFR ,60 mL/min/1.73 m2 (confirmed CKD) as a function of age. ...
en] Blood Chemical Analysis/methods ; Creatinine/blood ; Cystatin C ; Cystatins/blood ; Enzyme-Linked Immunosorbent Assay ; Glomerular Filtration Rate/physiology ; Humans ; Immunoassay ; Kidney Function ...
Amyloid beta deposition in the brain is the hallmark of Alzheimers disease. Co-deposition of other amyloidogenic proteins like transthyretin, human cystatin C have been found in the plaques along with A beta. Revealing the details of the interaction between these proteins with A beta peptide in vitro is able to provide insight into finding new therapies for the disease ...
References for Abcams Human Cystatin C ELISA Kit (ab119589). Please let us know if you have used this product in your publication
The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin C- and creatinine-based equations, that cystatin C-based GFR-estimating equations are superior to creatinine-based equations in predicting end-stage renal disease, cardiovascular manifestations, hospitalisation and death, and, finally that cystatin C is required to diagnose the new syndrome "Shrunken Pore Syndrome" with its high mortality and morbidity, even in the absence of reduced GFR ...
in American Journal of Kidney Diseases (2013), 61(2), 279-284. Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of ... [more ▼]. Background: The utility of serum cystatin C (SCysC) as a filtration marker in kidney transplantation is uncertain. We took advantage of the recent validation of a reference calibrator for SCysC and of newly developed CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations (2012) expressed for use with standardized SCysC level to reassess the performance of SCysC as a filtration marker in kidney transplant recipients. Study Design: Study of diagnostic test accuracy. Setting & Participants: 670 kidney transplant recipients from 3 centers undergoing glomerular filtration rate (GFR) measurements from December 2006 to November 2012. Index Test: Estimated GFR (eGFR) using the 2012 SCysC-based and serum creatinine ...
A partial cystatin cDNA from rainbow trout was generated by reverse transcription polymerase chain reaction with two degenerate primers. The partial cystatin PCR product was 168 bp and used to screen trout liver λgt 11 cDNA library. Four positive clones were isolated and designated as cstl, cst2, cst3 and cst4. Only cst2 contained the full-length cystatin cDNA which was 674 bp and included 5 untranslated region and the polyadenylation signal sequence AATAAA in the 3 region. Translation of the cDNA contains 132 amino acid residues. Comparison of the amino acid sequence with those of family II cystatin indicated that the 21 amino acids at N-terminal end is a signal peptide that leads to cystatin secretion, and the 111 amino acids are mature cystatin. Four cysteine residues in the cystatin may form two disulfide bonds for the secondary structure. Cst2 was subcloned into pGEM-3z for Northern and Southern blot experiments. Northern blot indicated that trout cystatin mRNA is about 750 bp. Cystatin ...
OBJECTIVE: To explore the correlation between susceptibility weighted imaging (SWI) manifestation and serum cystatin C level for delayed graft function (DGF). METHODS: The conventional MRI, SWI and serum cystatin C of 27 cases with DGF in nephrotransplantation center in Third Affiliated Hospital of Suzhou University from September 2014 and August 2015 were retrospectively analyzed.By contrasting conventional MRI images of transplanted kidney in DGF, the imaging manifestations of benign tumors such as cysts and angiomyolipomas were excluded on SWI images, and then making the renal cortex as the reference, if the abnormal signal lesions were found in the transplanted kidney, the location and signal intensity would be analyzed ...
The precursor protein in cystatin C amyloidosis (ACys) is cystatin C, which is a cysteine protease inhibitor that contains a point mutation. This condition is clinically termed HCHWA, Icelandic type. ... more
Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease Yusuf à etin Doðaner1, à mit ... ...
TY - JOUR. T1 - Biological Variation of Creatinine, Cystatin C, and eGFR over 24 Hours. AU - Hilderink, Judith M.. AU - van der Linden, Noreen. AU - Kimenai, Dorien M.. AU - Litjens, Elisabeth J. R.. AU - Klinkenberg, Lieke J. J.. AU - Aref, Breshna M.. AU - Aziz, Fahra. AU - Kooman, Jeroen P.. AU - Rennenberg, Roger J. M. W.. AU - Bekers, Otto. AU - Koopmans, Richard P.. AU - Meex, Steven J. R.. PY - 2018/5. Y1 - 2018/5. KW - GLOMERULAR-FILTRATION-RATE. KW - CHRONIC KIDNEY-DISEASE. KW - CARDIAC TROPONIN-T. KW - COOKED-MEAT MEAL. KW - SERUM CREATININE. KW - CLINICAL-CHEMISTRY. KW - CRITICAL-APPRAISAL. KW - INDIVIDUALS. KW - VARIABILITY. KW - ANALYTES. U2 - 10.1373/clinchem.2017.282517. DO - 10.1373/clinchem.2017.282517. M3 - Article. VL - 64. SP - 851. EP - 860. JO - Clinical Chemistry. JF - Clinical Chemistry. SN - 0009-9147. IS - 5. ER - ...
Adam Shardlow and colleagues investigate whether using cystatin C in addition to serum creatinine can improve diagnosis and risk prediction for progression of CKD among patients in primary care, and estimate the costs of additional testing and monitoring.
Adam Shardlow and colleagues investigate whether using cystatin C in addition to serum creatinine can improve diagnosis and risk prediction for progression of CKD among patients in primary care, and estimate the costs of additional testing and monitoring.
Gentaur molecular products has all kinds of products like :search , ICL \ Cystatin C Reference Standard Whole Serum Host Human \ RS-80CYS for more molecular products just contact us
Buy our Mouse Cystatin C peptide. Ab22916 is a blocking peptide for ab2516 and has been validated in BL. Abcam provides free protocols, tips and expert support…
Cystatin C protein (recombinant) can be used as antigen in immuno-based applications. It can also be used to formulate calibrators and controls. Size: 1 mg.
There are several key findings in this report. First, we observed in subjects with CKD that TMAO levels are not only elevated when compared with non-CKD subjects but also portend poorer overall survival. Second, we observed that within the non-CKD cohort, higher levels of TMAO portend poorer survival both within the cohort of low levels and high levels of cystatin C (stratified at median levels). Interestingly, the prognostic value for the highest TMAO quartile in predicting future mortality risk in this cohort remained robust even after adjustment for traditional risk factors. Third, extending to animal models studies, dietary exposure of either choline or TMAO lead to the development of renal tubulointerstitial fibrosis and early measures of dysfunction (elevated cystatin C). These studies thus suggest both a causal relationship and clinical relevance of dietary choline-induced, gut microbiota-mediated, TMAO formation in CKD development and progression.. TMAO is a low molecular weight compound ...
Figure 2. Box plots for the six biomarkers evaluated. The vertical box represents the 25th percentile (bottom line), median (middle line), and 75th percentile (top line) values whereas the vertical bars represent the intervals between maximum and minimum values: (A) urinary neutrophil gelatinase associated lipocalin (uNGAL) levels, (B) uNGAL/matrix metalloproteinase-9 (MMP-9), (C) urinary IL-18 (uIL-18), (D) urine hepatocyte growth factor (uHGF), (E) urinary cystatin C (uCystatinC), and (F) urinary creatinine (uCreatinine). *P , 0.05, **P , 0.01. The mean (SD) of the largest relative change of uNGAL for recovery and nonrecovery were −1.1 (1.5) and + 4.8 (10.0), P = 0.01, respectively. The mean (SD) of the largest relative change of uHGF for recovery and nonrecovery were −1.0 (1.5) and + 5.8 (12.8), P = 0.003, respectively. ...
CKD and systemic inflammation are recognized risk factors for sepsis [9-11]. While Cyst-C has been studied as a marker of renal function, other studies highlight the potential role of Cyst-C as a marker of more general systemic inflammation [13,14,36,37]. In this analysis, elevated serum Cyst-C , 1.12 mg/dL measured at baseline was independently associated with future risk of sepsis events. This association persisted after adjusting for common markers of CKD (abnormal creatinine-based eGFR and elevated ACR) as well as elevated hsCRP, a marker of systemic inflammation [38]. These observations suggest that Cyst-C may indicate the presence of additional steps in the sepsis pathophysiological pathway that are not completely explained by renal disease or systemic inflammation. Our findings originate from REGARDS, one of the largest population-based cohorts in the US and encompass sepsis events over a 10-year span.. Recent attention has focused on the utility of serum Cyst-C as a marker of renal ...
The combined creatinine-cystatin C equation performed better than equations based on either of these markers alone and may be useful as a confirmatory test for chronic kidney disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases.).
We compared participants with HF who survived with those who died during follow-up. To evaluate measures of renal function as predictors of mortality, cystatin-C and creatinine were evaluated as continuous variables per standard deviation. We used multivariate Cox proportional hazards models that were adjusted for all the aforementioned characteristics as candidate predictors. Covariates whose entry into the model changed the coefficient of cystatin-C by 5% were retained and included in the final models for cystatin-C, creatinine, and estimated GFR. The adjustment variables were age, gender, body mass index, previous stroke, cancer, hypertension, anemia, and lipid-lowering medications. Hypertension was defined as systolic blood pressure ,140 mm Hg, and anemia was defined as hemoglobin ,12 g/dl for men and ,13 g/dl for women. We also evaluated models that included both cystatin-C and creatinine. We did not evaluate estimated GFR as a continuous variable because of the implications of modeling ...
특화 정밀상담(신장), Calcium (24hrs urine), Magnesium (24hrs Urine), Phosphorus (24hrs Urine), Uric acid (24hrs urine), Protein (24hr urine), Creatinine (24hrs urine), urine creatinine, Creatinine Clearance (24hrs Ccr), Microalbumin (24hrs urine), urine microalbumin, Urine Electrolyte Panel(24hrs urine), Serum cystatin C, Dysmorphic RBC, U/A (Stick + Microscopy) Panel, 소변암세포검사, Citrate(24hrs urine)(외주), Oxalate(24hrs urine)(외주), Abd (Kidney) CT - ...
특화 정밀상담(신장), Calcium (24hrs urine), Magnesium (24hrs Urine), Phosphorus (24hrs Urine), Uric acid (24hrs urine), Protein (24hr urine), Creatinine (24hrs urine), urine creatinine, Creatinine Clearance (24hrs Ccr), Microalbumin (24hrs urine), urine microalbumin, Urine Electrolyte Panel(24hrs urine), Serum cystatin C, Dysmorphic RBC, U/A (Stick + Microscopy) Panel, 소변암세포검사, Citrate(24hrs urine)(외주), Oxalate(24hrs urine)(외주), Abd (Kidney) CT - ...
mg/g, and at different stages of CKD (G1/G2, A1/A2). In this study, the authors identified serum cystatin C and urine IgG, transferrin, and NGAL as the best indicators of glomerular damage, whereas urine NGAL, KIM-1, or uromodulin could be indicators of tubular damage. The urinary markers are associated with increase of albuminuria, while both serum and urine NGAL were significantly associated with eGFR decline. Although these findings still need to be confirmed in a large number of patients, these data indicates that combination of biomarkers in serum and urine could be useful for the clinical management of diabetic patients.. Cardiovascular and heart damage is the most frequent consequence of CKD. Serum levels of sST2 (soluble suppression of tumorigenicity 2), a novel biomarker of fibrosis and cardiac remodeling in heart failure patients, are independent of eGFR and age. Previous studies described that the BCN Bio-HF score, an algorithm derived from a real-life cohort, based on soluble ST2 in ...
Nearly 1 in 10 Americans have diabetes, and the number keeps growing. Diabetes is the leading cause of chronic kidney disease (CKD), with 44% of all cases of kidney failure the result of diabetes. By the time patients are in kidney failure, called end-stage renal disease, they require dialysis or transplantation.
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
All reagents should be stored refrigerated (2-8°C). Return all reagents to 2-8°C promptly after use. Unopened reagents can be used for one year from the date of manufacture, as indicated by the expiration date on the package and bottle labels. Opened reagents can be used for one month if stored at 2-8°C ...
Assessing kidney function is an integral part of the practice of medicine. However, even the most accurate GFR estimates based on serum creatinine and cystatin...
After adjustments for glomerular filtration rate (GFR), levels of creatinine, cystatin C, and ß trace protein each remained directly associated with kidney failure but differed in their associations with mortality, according to a newly published study (J Am Soc Nephrol 2011 doi: 10.1681/ASN.2011070663). The findings add to the body of knowledge about how these markers contribute prognostic information beyond that reflected in GFR.
BACKGROUND: Cystatin C (cC) is a cysteine protease inhibitor that may influence immune response. Our aim was to test the effect of a high concentration of cC, characteristic for uremic patients, on neutrophil (PMN) apoptosis and respiratory burst, as well as the cC secretion from PMNs stimulated with proinflammatory cytokines. MATERIAL/METHODS: PMNs from 35 healthy volunteers aged 27-61 years were cultured in presence of cC, IL-1beta or TNF-alpha. The percentage of apoptotic cells based on DNA depletion, Fas, FasL and caspase -3 expression were assessed ...
Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice ...
BACKGROUND: Serum cystatin C (sCysC) is used as biomarker for glomerular filtration rate (GFR). The effects of diabetes mellitus (DM) on renal function in dogs are unclear. Some renal variables have been evaluated in dogs with hyperadrenocorticism (HAC), but not sCysC. OBJECTIVES: The purpose of this study was the validation ... read more of a particle-enhanced nephelometric immunoassay (PENIA) for measuring canine sCysC, and to assess renal function in dogs with DM or HAC. METHODS: A PENIA was analytically validated for canine sCysC by determining imprecision and linearity. In a longitudinal 6-month study, renal function of 14 DM dogs was assessed, using serum creatinine, GFR, urinary protein-to-creatinine (UPC) ratio, urinary markers, systolic blood pressure (SBP), and sCysC, and compared to 17 healthy dogs at baseline. Furthermore, sCysC was measured at initial presentation and during a 12-month follow-up in 22 HAC dogs. RESULTS: The sCysC intra- and inter-assay variation coefficients were , ...
Gentaur molecular products has all kinds of products like :search , Ray Biotech \ Recombinant Human Cystatin C \ 228-10301-3 for more molecular products just contact us
The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance of cystatin C (CysC) and complement component 1q (C1q) for LN. A case-control study that included 905 patients with systemic lupus erythematosus (SLE) without LN (group SLE), 334 patients with active lupus nephritis (group LNA), 255 patients with inactive lupus nephritis (group LNI), and 497 healthy individuals (group HC) was performed in Mianyang Central Hospital from March 2017 to December 2018. The serum levels of CysC, C1q, urea (Urea), and creatinine (Creat) were measured, and 2 estimated glomerular filtration rates (eGFRCysC and eGFRCreat) were calculated by equations which were based on serum CysC established by our group and the modification of diet in renal disease (MDRD), respectively. ANOVA analysis or Kruskal-Wallis test was used for comparing the differences among the groups, and
As with industrious employees, it is hard to spur greater productivity in an enzyme by simply cracking the whip. However, clearing distractions might do the trick. Taking this strategy into an Alzheimer disease mouse model, scientists have boosted the activity of an Aβ-degrading enzyme by reducing levels of an endogenous inhibitor. The enzyme, cathepsin B (CatB), caught the attention of Li Gan at the Gladstone Institute of Neurological Disease in San Francisco several years ago when it appeared to prevent buildup of amyloid plaques in the brains of AD mice overexpressing mutant human amyloid precursor protein (APP). In the October 23 Neuron, Gan and colleagues now report that APP mice lacking cystatin C (CysC)-an inhibitor of cysteine proteases including CatB-have lower soluble Aβ levels and reduced Aβ-associated deficits in cognition, behavior, and synaptic plasticity compared to APP/CysC+/+ mice. By crossing the animals onto a CatB-null background, they show that these benefits depend on ...
Introduction: Kidney function is an established risk factor for cardiovascular disease (CVD) events [1]. In a high risk CVD population it had been suggested that cystatin C based equations to estimate glomerular filtration rate (eGFR) show better prognostic value than creatinine (Cr) based ones [2]. However, in population-based settings the situation is less clear. In addition it is controversial whether albuminuria carries additional information. The aim of this study was to estimate the association of Cr- and cystatin C-based eGFR and albuminuria with CVD in a population of older adults.. Material & methods: The study included participants, aged 50-75 years, of a statewide cohort study (ESTHER) conducted in the state of Saarland. Stages of chronic kidney disease (CKD) were defined by the Cr based simplified Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology (CKD-EPI), and by the cystatin C based Arnal-Dade estimating equations. Active follow-up was conducted ...
article{b6a0ecd9-da63-4a19-b309-0a87b322a637, abstract = {A polymorphism in the coding region of the human cystatin D gene has been detected by direct sequencing of amplified DNA from different individuals. The variation, resulting from a T/C transition in exon 1 of the gene, causes an amino acid variation, Cys/Arg, at the protein level. An allele-specific oligonucleotide hybridization assay was developed and used to demonstrate this polymorphism in the population. The deduced frequencies were 0.55 and 0.45 for the Cys and Arg variant-encoding alleles, respectively.}, author = {Balbin, Milagros and Freije, José P and Abrahamson, Magnus and Velasco, Gloria and Grubb, Anders and Lopez-Otin, Carlos}, issn = {1432-1203}, language = {eng}, number = {6}, pages = {668--669}, publisher = {Springer}, series = {Human Genetics}, title = {A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level}, url = {http://dx.doi.org/10.1007/BF00202491}, ...
The individual study sponsor(s) had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Dr. Isgum is supported by research grants from Pie Medical Imaging, 3Mensio Medical Imaging B.V., the NWO and Foundation for Technological Sciences under Project 12726, The Netherlands Organization for Health Research and Development, and the Dutch Cancer Society. Dr. Arpegård has received funding through the Stockholm County Council (combined clinical residency and PhD training program). Dr. Amouyel has received personal fees from Servier, Hoffman Laroche, Total, Genoscreen, Alzprotect, Fondation Plan Alzheimer, and Takeda outside of the submitted work; and has shares in Genoscreen. Dr. Morris is a Wellcome Trust Senior Fellow in Basic Biomedical Science under grant number WT098017. Dr. Worrall has received compensation for his role as deputy editor of the Journal of Neurology; and has ...
Cystatin B: An intracellular cystatin subtype that is found in a broad variety of cell types. It is a cytosolic enzyme inhibitor that protects the cell against the proteolytic action of lysosomal enzymes such as CATHEPSINS.
IFN-γ is so far the only cytokine able to induce by its own the synthesis of iNOS and the release of NO from MPM. However, it has been shown recently that IFN-γ-induced TNF-α is a prerequisite for in vitro production of NO released by MPM [2,4]. In addition to TNF-α, many other cytokines and bacterial products including transforming growth factor β, IL-10, TNF-α/β, GM-CSF and LPS [5-8,13,16,22,25] can also trigger NO production by acting in synergistic pairs on IFN-γ-activated MPM. We recently demonstrated that representative members of the cystatin superfamily, and particularly CC, can stimulate the release of NO from IFN-γ-activated MPM by stimulating the iNOS/NO system [12]. The results reported here show that CC stimulates the synthesis of TNF-α and IL-10 and upregulates the NO production by IFN-γ-activated MPM. The early iNOS induction by IFN-γ, followed by a CC stimulation, leads to maximal production of NO by MPM. This suggests that CC acts as an amplifier, but only if the ...
J:162893 Baston-Buest DM, Schanz A, Buest S, Fischer JC, Kruessel JS, Hess AP, The embryos cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S in mice. Reproduction. 2010 Apr;139(4):741-8 ...
A blood component called cystatin C, used to test for early-stage kidney impairment, also may be a very early marker for those at risk of pre-diabetes
CST3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 141 amino acids and having a molecular mass of 15.6kDa.
Dr. Schwartz is not only an accomplished practitioner but is also an experienced educator of aesthetic and reconstructive breast surgery.
Detailed profile of Dr. Stephen L Schwartz, MD, a Urologist - General Terre Haute IN. See insurances he accepts. Read ratings and reviews from other patients.
If you are Private Browsing in Firefox, "Tracking Protection" may casue the adblock notice to show. It can be temporarily disabled by clicking the "shield" icon in the address bar. ...
Abstract: Objective To evaluate the value of cystatin C(CysC)in early diagnosis and prognostic prediction of acute kidney injury(AKI)in patients with liver cirrhosis. Methods Serum levels of CysC and creatinine(SCr)were detected in 825 patients with liver cirrhosis,and the dynamic changes observed.Employing Child-Pugh grading of liver cirrhosis,the incidence of cirrhosis at different levels was analyzed.The relation ship between CysC,SCr and their abnormal rates,association of liver cirrhosis complicated with AKI with its prognosis was analyzed. Results The levels of CysC in the patients gradually elevated and the detection rate of abnormal CysC markedly increased along with heightened of Child-Pugh grading,the indifferences among each grade was significant(F=292.21,q=7.12-19.36,P,0.01;χ~2=24.96,P,0.01).The level of CysC was also elevated along with increased damage of liver function(F=345.56;q=12.48,16.35;P,0.01).The detection rate of abnormal SCr in grade C was higher than that in grades A ...
OBJECTIVE: A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS). METHODS: Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects. RESULTS: Full-length CysC (13.4kDa) concentration was similar in MS and control samples. The 12.5kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C. INTERPRETATION: The 12.5kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS. Ann Neurol 2007;62:193-196. ...
Hu Y, Hung AC, Cui H, Dawkins E, Foa L, et al., APP stimulates neural stem/progenitor cell proliferation by increasing cystatin C secretion. (Poster), 33rd Annual Meeting Australian Neuroscience Society, January, Melbourne, Australia (2013) [Conference Extract ...
Sigma-Aldrich offers abstracts and full-text articles by [Zaccaria Ricci, Rosa Luciano, Isabella Favia, Cristiana Garisto, Maurizio Muraca, Stefano Morelli, Luca Di Chiara, Paola Cogo, Sergio Picardo].
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The standard indicators of renal function are serum levels of urea nitrogen and creatinine; their ratio is normally about 10:1. This ratio may increase when renal perfusion or urine flow is decreased, as in urinary tract obstruction or dehydration. Because serum urea nitrogen levels are more affected by these and other factors (eg, nitrogen intake, catabolism, use of corticosteroids) than are creatinine levels, the most reliable single indicator of glomerular function is the serum level of creatinine. For example, an increase in serum creatinine from 0.5 to 1.0 mg/dL represents a 50% decrease in GFR (glomerular filtration rate). Norms for serum creatinine relate to muscle mass. Therefore, only larger adolescents should have levels exceeding 1 mg/dL. Serum cystatin C has been proposed to be a more reliable indicator of glomerular function but may be less widely available, with variable reference ranges in the pediatric population and invalid values observed in the setting of corticosteroid ...
OBJECTIVES: Both renal disease and systemic inflammation predict non-AIDS-defining events and overall mortality in HIV-infected patients. Here, we sought to determine the relationships between renal disease and circulating inflammation markers.. METHODS: We performed a secondary analysis of AIDS Clinical Trials Group Study A5224s to determine if markers of renal disease [urine protein:creatinine ratio (uPCR), urine albumin:creatinine ratio (uACR), and estimated glomerular filtration rate (eGFR), using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine and cystatin C-creatinine] were associated with markers of systemic inflammation [high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor (TNF)-α, soluble TNF-α receptor I (sTNFRI), sTNFRII, and soluble vascular cellular and intercellular adhesion molecules]. We correlated these renal and inflammatory markers prior to antiretroviral initiation and after 96 weeks of therapy.. RESULTS: We found that eGFR ...
Find and order accessory reagents and products like Human Cystatin B / CSTB ELISA Pair Set on www.antibodies-online.com. Order product ABIN2010313.
Cystatin B antibody for detecting human Cystatin B. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
Background. Hypoxia resultant from haemorrhagic shock is the primary cause of kidney damage. Application of normobaric hyperoxia therapy (NHT) is an acceptable treatment for acute haemorrhagic shock. We investigated the effect of NHT on amelioration of haemorrhagic shock-induced rat renal failure.. Methods. Twenty-four Sprague-Dawley rats were subjected to gradual blood withdrawal/reperfusion, followed by 12-h, 24-h or 48-h NHT. Verification/monitoring of intrarenal hypoxia was performed using Hypoxyprobe-TM-1. Subsequently, cystatin C, urea and creatinine were assessed in serum by a Hitachi autoanalyser, and NO, 3-nitro-tyrosine, STAT-8-isoprostane and NF-kB in renal medullae and cortices by specific ELISAs.. Results. In rats subjected to haemorrhagic shock, 12- to 48-h NHT significantly reduced intrarenal Hypoxyprobe-TM-1 stained areas and attenuated augmentation of urea, creatinine and cystatin C. Haemorrhagic shock resulted in a 10-fold drop of intrarenal NO availability. 12-h and 24-h, but ...
Alignment of cystatin superfamily domain.The domain was aligned using ClustalW and adjusted manually. (A) The three parts of the papain binding domain (G, QXVXG
Accurate assessment of kidney function can assist appropriate clinical care, but most estimates of creatinine clearance were developed in populations that included no or few older adults and do not perform well in this group. Researchers developed and validated 2 estimates of glomerular filtration rate (GFR), one based on creatinine only and another based on both creatinine and cystatin C measurements, in a sample of adults aged 70 years or older. Both estimates showed excellent agreement with directly measured GFR and may provide more accurate assessment of kidney function in older adults than currently used measures. ...
Acute kidney injury (AKI) is the generic term for an abrupt and sustained decrease in renal function, resulting in the retention of waste products. It is associated with high morbidity and mortality. An early accurate diagnosis is essential to improve the prognosis of this disease. The development of a model for predicting risk of AKI mixed with biomarkers (creatinine, cystatin C) and clinical data is a promising approach. ...
Though significant progress has been made towards new diagnostic approaches for early detection of acute kidney injury (AKI) induced by different factors, there is still an urgent demand for a more specific and predictive biomarker for each type. The aim of this study is to unravel the potential diagnostic utility of circulating osteoprotegerin (OPG) in septic patients who developed AKI in the ICU, compared to cystatin C (a renal function maker) and KIM-1 (a kidney damage marker).. ...
۞:... ۞.From the SLC22A6 ,in vivo and renal slice excretion of para-aminohippurate (PAH) is significantly reduced Drug Relationships also demonstrated PAH uptake in Xenopus oocytes. That the promoter region contains TATA and CCAAT boxes. The promoter region contains TATA and CCAAT boxes inhibited by I-kappa-B proteins this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions, shares an operon encoded as some (GABA) neurotransmitter (untranscribed (~TATA)gatAs. The 5 (also called intA)) derivatives (PBT) and the protein sequence of cystatin C isolated from human urine and human saliva CST3 gene _found to be proximal to the breakpoint_ V-alpha-14+ subset of regulatory natural killer T (NKT) cells born from interbred Y+LAT/V+alpha 14/ A-/-, mice born from the interbred species. Using mice doubly deficient in either A20 and Tnf or A20 and Tnfr1, participate in mediating most of the therapeutic interventions that removes ...
In the current study, we demonstrated that the estimation of renal function by eGFRcr, eGFRcys, and eGFRcr-cys led to overestimation of renal function in diabetic patients. Our study also showed that the correlation coefficients and ICCs of each of three eGFR measures and Cin in diabetic patients were lower than those of nondiabetic subjects and that the intercepts of the regression lines in diabetic patients were significantly higher than those in nondiabetic subjects, indicating that each of three eGFR measurements in diabetic patients are more inaccurate than in the nondiabetic subjects. Further, the values of each of the three eGFR/Cin ratios (eGFRcr/Cin, eGFRcys/Cin, and eGFRcr-cys/Cin) correlated significantly with the glycemic control indices of hemoglobin A1c and GA, suggesting that the three values of eGFR estimation (i.e., eGFRcr, eGFRcys, and eGFRcr-cys) overestimate renal function as glycemic controls worsened. Thus, the apparent increase in each of three eGFR values relative to Cin ...
Nephrology Now is an editorially independent and free service to help you stay up to date with new developments in Nephrology ...
Reaktivität: Human, Affe, Maus and more. 76 verschiedene CST4 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
Monoclonal Antibody to Cystatin-C -Maine Biotechnology Services, Anti-Cystatin C available in bulk or samples 207-797-5454 or [email protected]
For someone with no prior history of diabetes, an A1C level below 5.7 percent is considered normal. A1C levels from 5.7 to 6.4 percent indicate prediabetes, and levels at 6.5 percent or above...
Learn more about Dr. Curtis Schwartz and other urologists in Fort Lauderdale, FL. See treatments provided, insurance accepted, and more.
In an intimate talk, Barry Schwartz dives into the question How do we do the right thing? With help from collaborator Kenneth Sharpe, he shares stories that illustrate the difference between following the rules and truly choosing wisely.
You have to give Head Of Femur credit for sticking to their guns. Whatever it is theyre trying to do, that goal definitely doesnt include selling records, and for that alone they are to be commended. Head Of ... ...
Is the Chronic Kidney Disease Epidemiology Collaboration creatinineâ cystatin C equation useful for glomerular filtration rate estimation in the elderly? Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Peoples Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinineâ cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was
Background. High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In breast cancer, several recent studies have indicated that loss of the cysteine protease inhibitor cystatin E/M leads to increased growth and metastasis. Although cystatin E/M is normally expressed in the skin, its role in cysteine protease regulation and progression of malignant melanoma has not been studied.. Methods. A panel of various non-melanoma and melanoma cell lines was used. Cystatin E/M and C were analyzed in cell media by immunoblotting and ELISA. Legumain, cathepsin B and L were analyzed in cell lysates by immunoblotting and their enzymatic activities were analyzed by peptide substrates. Two melanoma cell lines lacking detectable secretion of cystatin E/M were transfected with a cystatin E/M expression plasmid (pCST6), and migration and invasiveness were studied by a Matrigel invasion assay.. Results. Cystatin E/M was ...
age-related macular degeneration Genetics Home Reference provides information about age-related macular degeneration. hereditary cerebral amyloid angiopathy At least one mutation in the CST3 gene has been found to cause hereditary cerebral amyloid angiopathy, a condition characterized by stroke and a decline in intellectual function (dementia), which begins in mid-adulthood. The CST3 gene mutation that has been identified causes a form of hereditary cerebral amyloid angiopathy known as the Icelandic type. This mutation replaces the protein building block (amino acid) leucine with the amino acid glutamine at position 68 in the cystatin C protein (written as Leu68Gln or L68Q). This abnormal cystatin C protein is less stable and is more prone to cluster together (aggregate) than the normal protein. The aggregated protein forms clumps called amyloid deposits that accumulate in the blood vessel walls primarily in the brain, but also in blood vessels in other areas of the body such as the skin, ...
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored. As much as 10 % of HIV patients may suffer from chronic kidney disease, an affection that is not symptomatic until a very late stage secondary to HIV infection, drugs exposure, hypertension or diabetes. Guidelines have suggested that renal function should be regularly assessed in HIV patients to perform early diagnosis for chronic kidney disease and allow initiation of preventive measures aimed at preserving renal function.. Plasma creatinine dosage is the easiest way to evaluate renal function but glomerular filtration rate estimation from cockcroft or MDRD formulae is a much better indicator of renal function. Other markers like cystatin C may be used. None of these markers has been validated in HIV patients. Therefore our study is aimed at comparing validity of creatinine clearance estimation ...
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored. As much as 10 % of HIV patients may suffer from chronic kidney disease, an affection that is not symptomatic until a very late stage secondary to HIV infection, drugs exposure, hypertension or diabetes. Guidelines have suggested that renal function should be regularly assessed in HIV patients to perform early diagnosis for chronic kidney disease and allow initiation of preventive measures aimed at preserving renal function.. Plasma creatinine dosage is the easiest way to evaluate renal function but glomerular filtration rate estimation from cockcroft or MDRD formulae is a much better indicator of renal function. Other markers like cystatin C may be used. None of these markers has been validated in HIV patients. Therefore our study is aimed at comparing validity of creatinine clearance estimation ...
Apoptose er programmert celledød for å fjerne uønskede celler og er en felles egenskap for alle flercellede organismer. Caspase-3 er involvert i intracellulære signalkaskader ved apoptose. En ubalanse i regulering av apoptose kan føre til kreftutvikling. Apoptose spiller en viktig rolle i flere andre sykdommer som immunologisk, iskemiske, og nevrodegenerative sykdommer. For å undersøke betydningen av proteasen legumain og proteaseinhibitoren cystatin E/M for caspase-3 aktivitet, ble det brukt HEK293 (normale kontroll celler), M38L (overutrykker legumain) og M4C (overutrykker cystatin E/M) celler. Cellene ble stimulert med dødsstimulerende stoffer som staurosporin og Leu-Leu-OMe. Staurosporin er kjent for å være en kinasehemmer. Leu-Leu-OMe øker lysosomal membranpermeabilitet. Proteaser som er involvert i apoptose vil dermed frigjøres fra lysosomer til cytosol. Legumain som befinner seg i lysosomene, kan frigjøres til cytosol og dermed påvirke aktiviteten av caspase-3 eller andre ...
Cystatin E/M/CST6 products available through Novus Biologicals. Browse our Cystatin E/M/CST6 product catalog backed by our Guarantee+.
|i|Background:|/i| Whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with kidney function decline has not been well studied. |i|Me
Compare cystatin A (stefin A) ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
A major challenge in preventing DN is the difficulty in accurately identifying high-risk patients and the need for additional therapeutic targets. The aim of this study was to evaluate the association of insulin sensitivity and DN. The data show that greater insulin sensitivity at baseline independently predicts lower risk of developing ACR ≥30 mg/g and confers protection from a rapid decline of GFR as calculated by CKD-EPI cystatin C.. The association between reduced insulin sensitivity and diabetes complications is increasingly recognized, but it is not a recent discovery. In 1968, Martin and Stocks (27) showed that microvascular complications were associated with reduced insulin sensitivity in long-standing type 1 diabetes. In 1993, Yip et al. (28) explored insulin resistance as an underlying factor in type 1 diabetes and found reduced insulin sensitivity, measured by GDR, in a small group with microalbuminuria, whereas Orchard et al. (13) later demonstrated that eGDR (a marker of insulin ...
Borisov, N.M.; Terekhanova, N.V.; Aliper, A.M.; Venkova, L.S.; Smirnov, P.Yu.; Roumiantsev, S.; Korzinkin, M.B.; Zhavoronkov, A.A.; Buzdin, A.A., 2014: Signaling pathway activation profiles make better markers of cancer than expression of individual genes
H3.3 nucleosome splitting events are better markers for active transcription than H3.3 nucleosome occupancy.(A) Split H3.3 nucleosomes were enriched in the top
The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.. Subscribe. ...
Uremia is a Greek word that means "urine in the blood". Uremia develops as the kidneys fail and are unable to remove wastes from the body. There are many symptoms of uremia that occur as kidney function declines. Before severe uremia develops, treatments such as dialysis and transplantation are usually needed. The timing of dialysis will depend on your symptoms and varies from person to person.. ...
Totally Laparoscopic Puestow Procedure Presented by Jennifer Schwartz at the SAGES 2014 Meeting; Panel - Concurrent Session SS2 Video 1 Rosara Milstein, MS, Jennifer Schwartz, MD, Andrei Manilchuk, MD, David B Renton, MD; The Ohio State University Points of interest: PMI-11 sec historical statement-22 sec CT-31 sec procedure begins-46 sec post op course-6:05 Keyword(s): acessed, […] ...
Complete your Josh Schwartz (6) record collection. Discover Josh Schwartz (6)s full discography. Shop new and used Vinyl and CDs.
Background. Measuring glomerular filtration rate (GFR) is an important assessment in peritoneal dialysis patients. In clinical practice, it is commonly measured by calculating the mean of the urinary clearance of urea and creatinine (GFRUrCl) but this process is time consuming and unreliable. We wished to compare several estimates of GFR including residual GFR estimated from cystatin C (GFRCysC) using a published equation (Hoek), GFRUrCl and 51Cr-ethylenediaminetetraacetic acid (EDTA) clearance, in peritoneal dialysis patients.. Methods. GFRCysC, GFRUrCl and 51Cr-EDTA clearance were measured in 28 patients undergoing peritoneal dialysis in a single dialysis unit.. Results. GFRCysC was related to GFRUrCl (Spearmans rank correlation coefficient rs = 0.44; P = 0.0185) and to 51Cr-EDTA clearance (rs = 0.48; P = 0.0099). GFRCysC values were significantly (P = 0.0077) lower than 51Cr-EDTA clearance results (mean bias −19.7%). However, GFRCysC did not differ significantly (P , 0.05) from ...
This page includes the following topics and synonyms: Creatinine Clearance, Glomerular Filtration Rate, GFR, CrCl, Cockcroft-Gault, Modification of Diet in Renal Disease, MDRD, Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI.
Cystatin-SN is a protein that in humans is encoded by the CST1 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. GRCh38: Ensembl release 89: ENSG00000170373 - Ensembl, May 2017 "Human PubMed Reference:". "Entrez Gene: CST1 cystatin SN". The MEROPS online database for ...
The aim of this study was to determine whether the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)- or Cockcroft-Gault (CG)-based estimated glomerular filtration rates (eGFRs) performs better in the cohort setting for predicting moderate/advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD ...
TY - JOUR. T1 - Limitations of estimating glomerular filtration rate from serum creatinine in the general population. AU - Rule, Andrew D. AU - Rodeheffer, Richard J.. AU - Larson, Timothy S.. AU - Burnett, John C Jr.. AU - Cosio, Fernando G. AU - Turner, Stephen T. AU - Jacobsen, Steven J.. PY - 2006. Y1 - 2006. N2 - OBJECTIVE: To compare estimated glomerular filtration rate (GFR) In the general population on the basis of equations derived from different subsets of the general population. PARTICIPANTS AND METHODS: Admits (ages ≥45 years) were randomly selected from 1997 to 2000 from the Olmsted County, Minnesota, population and had their serum creatinine levels measured. The GFR was estimated using previously reported equations derived tram a sample of patients with chronic kidney disease (CKD), a sample of healthy persons, and the combined samples. Serum creatinine was measured with the same assay used to derive these equations. RESULTS: Of 4203 subjects, 2042 (47% participation rate) were ...
In potential living kidney donors, glomerular filtration rate (GFR) is often evaluated from the creatinine clearance (Ccr) or is predicted using formulas based on serum creatinine (SCr) or cystatin C (SCys) concentration. Ultrasonography is used to evaluate renal structure and dimensions. The objective of the present study was to evaluate the possibility of estimation of GFR from echographic renal dimensions in 66 potential live kidney donors (46 women and 20 men; age range, 25-73 years). The GFR was measured as the renal clearance of technetium 99m diethylenetriamine pentaacetic acid. The GFR was also estimated from the SCr concentration using the Cockcroft-Gault (CG-Ccr) and Modification of Diet in Renal Disease (MDRD-GFR) formulas and from SCys (Cys-GFR). Renal diameters were measured using conventional gray-scale renal ultrasound to estimate total and parenchymal renal volume using ellipsoid formulas. The GFR was predicted from renal dimensions on the basis of their relationship to measured ...

*Unverricht-Lundborg disease

Cystatin B Characteristics[edit]. A recent study has attempted to describe the behavior of normal and mutated cystatin B as it ... The results show that cystatin B has a polymeric structure, and that the mutated form of cystatin B, which is present in ... The cause of ULD is known to be a mutation of the gene that produces cystatin B.[2] The disease is autosomal recessive, so both ... Current research links cystatin B to production of inhibitory neurons known as GABAergic neurons. It has shown that a lack of ...

*Chromosome 20

CST9L: Cystatin-9-like. *CSTL1: Cystatin-like 1. *CTCFL: CCCTC-binding factor-like ...

*Evolution of snake venom

A]: crotamine and cystatin. [B]: 12 toxin families, including CRiSPs and nerve growth factors. [C]: 2 toxin families, including ...

*Peptide transporter carbon starvation family

Cystatin A Schultz, JE; Matin, A (March 5, 1991). "Molecular and functional characterization of a carbon starvation gene of ...

*Egg white

Cystatin. 0.05% Ovalbumin is the most abundant protein in albumen. Classed as phosphoglycoprotein, during storage, it converts ...

*Kininogen

Closely related proteins include cystatin. Stefan Offermanns; Walter Rosenthal (2008). Encyclopedia of Molecular Pharmacology. ...

*CST7 (gene)

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-F is a protein that in humans is encoded by the CST7 gene. The cystatin superfamily encompasses proteins that contain ... The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. ... 2004). "Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting". Exp. Cell ...

*CSTL1

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-like 1 is a protein that in humans is encoded by the CSTL1 gene. The cystatin superfamily encompasses proteins that ... The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at ... The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. ...

*Cathepsin D

Lenarcic B, Krasovec M, Ritonja A, Olafsson I, Turk V (March 1991). "Inactivation of human cystatin C and kininogen by human ...

*Renal function

Cystatin C is freely filtered at the glomerulus. After filtration, Cystatin C is reabsorbed and catabolized by the tubular ... Cystatin C levels are therefore measured not in the urine, but in the bloodstream. Equations have been developed linking ... One of these is cystatin C, a ubiquitous protein secreted by most cells in the body (it is an inhibitor of cysteine protease). ... The most accurate is (sex, age and race) adjusted cystatin C, followed by (sex, age and race) adjusted creatinine and then ...

*Fetuin

... s are members of a family of proteins that evolved from the protein cystatin by gene duplication and exchange of gene ... Fetuins thus belong to the cystatin superfamily of proteins. Fetuin relatives within this superfamily are the histidine-rich ...

*CST6 (gene)

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-M is a protein that in humans is encoded by the CST6 gene. The cystatin superfamily encompasses proteins that contain ... 2006). "Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the ... The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, ...

*Rhipicephalus haemaphysaloides

"Functional characterization of a cystatin from the tick Rhipicephalus haemaphysaloides". Parasites & Vectors. Retrieved 11 ...

*Creatinine

Cystatin C - novel marker of kidney function. *Jaffe reaction - an example of creatinine assay methodology ...

*CST4

... cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of ... 1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-S is a protein that in humans is encoded by the CST4 gene. The cystatin superfamily encompasses proteins that contain ... The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in ...

*CST5

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-D is a protein that in humans is encoded by the CST5 gene. The cystatin superfamily encompasses proteins that contain ... The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in ... The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. ...

*Cotesia congregata

The fourth group are cystatin proteins, which will inhibit cysteine proteases. These will inhibit the breakdown of the proteins ...

*CST8 (gene)

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... Cystatin-8 is a protein that in humans is encoded by the CST8 gene. The cystatin superfamily encompasses proteins that contain ... The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in ... "Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)". The MEROPS online database for peptidases and their ...

*CST11

1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". ... The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in ... Cystatin-11 is a protein that in humans is encoded by the CST11 gene. The cystatin superfamily encompasses proteins that ... 2002). "Cystatin 11: a new member of the cystatin type 2 family". Endocrinology. 143 (7): 2787-96. doi:10.1210/en.143.7.2787. ...

*Staphopain A (Staphylococcus aureus)

Staphopain A is inhibited by phosphorylated cystatin α and α2-macroglobulin. Staphopain A can cleave and lower the activity α1- ... Inhibition of staphopain A by phosphorylated cystatin α did prevent colony formation in skin tissue, but the effect could also ... "Inhibition of cysteine protease and growth of Staphylococcus aureus V8 and poliovirus by phosphorylated cystatin alpha ... properties of peptidyl derivatives and cyclopeptides structurally based upon the inhibitory centre of human cystatin C. ...

*Clinical Biochemistry

Juliana F. Roos; Jenny Doust; Susan E. Tett; Carl M.J. Kirkpatrick (2007). "Diagnostic accuracy of cystatin C compared to serum ... serum cystatin C or equations?". Clinical Biochemistry. 40 (3-4): 153-161. doi:10.1016/j.clinbiochem.2006.10.014. ...

*Reference ranges for blood tests

Finney H, Newman DJ, Price CP (January 2000). "Adult reference ranges for serum cystatin C, creatinine and predicted creatinine ...

*Cathepsin L1

Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I (May 1998). "The role of Gly-4 of human cystatin A (stefin A ... 1998). "The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and ... Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, ... CTSL1 has been shown to interact with Cystatin A. GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, May 2017 "Human PubMed ...

*PDZD2

Lindahl P, Abrahamson M, Björk I (1992). "Interaction of recombinant human cystatin C with the cysteine proteinases papain and ...

*Aptamer

The Affimer scaffold is a stable protein based on the cystatin protein fold. It displays two peptide loops and an N-terminal ...

*Cathepsin L2

2006). "Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the ... A novel clue for the role of cystatin M/E in epidermal cornification". J. Biol. Chem. 281 (23): 15893-9. doi:10.1074/jbc. ...

Serum Cystatin C Predicts Mortality With Cirrhotic Ascites | Physicians Weekly for Medical News, Journals & ArticlesSerum Cystatin C Predicts Mortality With Cirrhotic Ascites | Physician's Weekly for Medical News, Journals & Articles

Serum Cystatin C Predicts Mortality With Cirrhotic Ascites by Physicians Weekly , Sep 22, 2017 , 0 comments ... "Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of ... The researchers found that serum creatinine and cystatin C levels were 0.9 and 1.1 mg/L, respectively. International normalized ... 22, 2017 (HealthDay News) - Serum cystatin C level is an excellent predictor of mortality in patients with cirrhotic ascites, ...
more infohttps://www.physiciansweekly.com/serum-cystatin-c-predicts-mortality-with-cirrhotic-ascites/

Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C A ROLE FOR AMYLOID IN MALE INFERTILITY - Lund...Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C A ROLE FOR AMYLOID IN MALE INFERTILITY - Lund...

Hereditary cystatin C amyloid angiopathy is an autosomal dominant disorder in which a variant form of cystatin C (L68Q) readily ... Heterozygous transgenic mice (L68Q) that express the human L68Q variant of cystatin C under the control of the mouse cystatin C ... Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C A ROLE FOR AMYLOID IN MALE INFERTILITY. Research ... L68Q protein deposits in human cystatin C amyloid angiopathy patients have also been found in tissues outside of the brain ...
more infohttps://portal.research.lu.se/portal/en/publications/fertility-defects-in-mice-expressing-the-l68q-variant-of-human-cystatin-c-a-role-for-amyloid-in-male-infertility

Urinary Neutrophil Gelatinase-Associated Lipocalin Is Excellent Predictor of Acute Kidney Injury in Septic Elderly PatientsUrinary Neutrophil Gelatinase-Associated Lipocalin Is Excellent Predictor of Acute Kidney Injury in Septic Elderly Patients

Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after ...
more infohttp://www.aginganddisease.org/EN/Y2018/V9/I2/182

Cerebral Amyloid Angiopathy: Emerging ConceptsCerebral Amyloid Angiopathy: Emerging Concepts

... cystatin C (ACys), prion protein (APrP), ABri/ADan, transthyretin (ATTR), gelsolin (AGel), and immunoglobulin light chain ...
more infohttp://j-stroke.org/journal/view.php?number=56&viewtype=pubreader

Cystatin CCystatin C

A cystatin C test may be used to screen for and monitor kidney dysfunction in special cases. ... Cystatin C is a relatively small protein that is filtered from the blood by the kidneys and broken down at a constant rate. ... Because cystatin C levels fluctuate with changes in GFR, there has been interest in the cystatin C test as one method of ... Lowry, F. (2009 February 27). Cystatin C, High Levels of Serum Cystatin C and Chronic Kidney Disease Linked to Age-Related ...
more infohttps://labtestsonline.org/tests/cystatin-c

What is cystatin C amyloidosis (ACys)?What is cystatin C amyloidosis (ACys)?

... is cystatin C, which is a cysteine protease inhibitor that contains a point mutation. This condition is clinically termed HCHWA ... The precursor protein in cystatin C amyloidosis (ACys) ... What is cystatin C amyloidosis (ACys)?. Updated: May 09, 2019 * ... encoded search term (What is cystatin C amyloidosis (ACys)?) and What is cystatin C amyloidosis (ACys)? What to Read Next on ... The precursor protein in cystatin C amyloidosis (ACys) is cystatin C, which is a cysteine protease inhibitor that contains a ...
more infohttps://www.medscape.com/answers/335414-106004/what-is-cystatin-c-amyloidosis-acys

Cystatin - WikipediaCystatin - Wikipedia

... cystatin C, a marker of kidney function), CST4, CST5, CST6, CST7, CST8, CST9, CST11, CSTA (cystatin A), CSTB (cystatin B)[ ... Chicken cystatin quickly passed the membrane of MCF-10A neo T cells and inhibited cathepsin B when it was acylated with fatty ... Cystatin: a protein that flips out! QUite Interesting PDB Structure article at PDBe Lee C, Bongcam-Rudloff E, Sollner C, Jahnen ... These are cystatin-like proteins found in a range of organisms: plant phytocystatins, fetuin in mammals, insect cystatins, and ...
more infohttps://en.wikipedia.org/wiki/Cystatin

Cystatin B - WikipediaCystatin B - Wikipedia

Cystatin-B is a protein that in humans is encoded by the CSTB gene. The cystatin superfamily encompasses proteins that contain ... "Entrez Gene: CSTB cystatin B (stefin B)". Pavlova, Alona; Björk Ingemar (Sep 2003). "Grafting of features of cystatins C or B ... Pol, E; Björk I (Sep 2001). "Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the ... 1997). "Unstable insertion in the 5 flanking region of the cystatin B gene is the most common mutation in progressive ...
more infohttps://en.wikipedia.org/wiki/Cystatin_B

Cystatin-C ArticlesCystatin-C Articles

The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma. ... Cystatin-C (Cys-C) has been reported as a valuable prognostic biomarker in various malignancies. However, its effect on upper ...
more infohttps://www.urotoday.com/tags/cystatin-c.html

RCSB PDB - 2OCT: Stefin B (Cystatin B) tetramerRCSB PDB - 2OCT: Stefin B (Cystatin B) tetramer

This proline residue is widely conserved throughout the cystatin superfamily, a member of which, human cystatin C, is the key ...
more infohttps://www.rcsb.org/structure/2OCT

Immunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis | SpringerLinkImmunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis | SpringerLink

Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory ... For example, cystatin C (10,11), as well as cystatin B (8) and E/M (9) have been shown to have antitumor effects via ... Cystatin 9 (CST9) is a small, ∼18-kDa human protein and a member of the type 2 cystatin superfamily that is compromised of 14 ... For instance, cystatin C is typically secreted and acts as a strong inhibitor of papainlike proteases, while cystatin F ...
more infohttps://link.springer.com/article/10.2119%2Fmolmed.2013.00081

NHANES 2001-2002:
						Cystatin C (Surplus) Data Documentation, Codebook, and FrequenciesNHANES 2001-2002: Cystatin C (Surplus) Data Documentation, Codebook, and Frequencies

SSCYPC - Cystatin C (mg/L). Variable Name: SSCYPC. SAS Label: Cystatin C (mg/L). English Text: Cystatin C (mg/L). Target: Both ... Surplus sera cystatin 99-02 weights. English Text: Surplus sera cystatin 99-02 weights. Target: Both males and females 12 YEARS ... Cystatin C (Surplus) (SSCYST_B) Data File: SSCYST_B.xpt First Published: June 2008. Last Revised: NA ... WTSCY4YR - Surplus sera cystatin 99-02 weights. Variable Name: WTSCY4YR. SAS Label: ...
more infohttps://wwwn.cdc.gov/Nchs/Nhanes/2001-2002/SSCYST_B.htm

NHANES 1999-2000:
						Cystatin C - Serum (Surplus) Data Documentation, Codebook, and FrequenciesNHANES 1999-2000: Cystatin C - Serum (Surplus) Data Documentation, Codebook, and Frequencies

SSCYPC - Cystatin C (mg/L). Variable Name: SSCYPC. SAS Label: Cystatin C (mg/L). English Text: Cystatin C (mg/L). Target: Both ... Surplus sera cystatin 99-02 weights. English Text: Surplus sera cystatin 99-02 weights. Target: Both males and females 12 YEARS ... Cystatin C - Serum (Surplus) (SSCYST_A) Data File: SSCYST_A.xpt First Published: June 2008. Last Revised: NA ... WTSCY4YR - Surplus sera cystatin 99-02 weights. Variable Name: WTSCY4YR. SAS Label: ...
more infohttps://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/SSCYST_A.htm

Mouse Cystatin C peptide (ab22916) | AbcamMouse Cystatin C peptide (ab22916) | Abcam

Buy our Mouse Cystatin C peptide. Ab22916 is a blocking peptide for ab2516 and has been validated in BL. Abcam provides free ...
more infohttp://www.abcam.com/mouse-cystatin-c-peptide-ab22916.html

Glomerular filtration rate estimated by cystatin C among different clinical presentations.  - PubMed - NCBIGlomerular filtration rate estimated by cystatin C among different clinical presentations. - PubMed - NCBI

Cystatin C has been proposed as an alternative marker for estimating GFR. The objective of this study was to compare cystatin C ... The relationship between cystatin C and GFR differed across clinical presentations. At the same cystatin C level, GFR was 19% ... Averaged estimates between cystatin C and serum creatinine equations further improved correlation (r(2)=0.891). Cystatin C ... Cystatin C and serum creatinine levels were obtained from adult patients (n=460) during an evaluation that included a GFR ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16408133?dopt=Abstract

Cst3 MGI Mouse Gene Detail - MGI:102519 - cystatin CCst3 MGI Mouse Gene Detail - MGI:102519 - cystatin C

J:228141 Ji X, et al., Cystatin C attenuates insulin signaling transduction by promoting endoplasmic reticulum stress in ...
more infohttp://www.informatics.jax.org/marker/MGI:102519

Anti-Cystatin C antibody (ab85790) Protocols | AbcamAnti-Cystatin C antibody (ab85790) Protocols | Abcam

Abcam provides specific protocols for Anti-Cystatin C antibody (ab85790) : Immunoprecipitation protocols, Immunohistochemistry ...
more infohttp://www.abcam.com/cystatin-c-antibody-ab85790-protocols.html

CST7 - Cystatin-F precursor - Homo sapiens (Human) - CST7 gene & proteinCST7 - Cystatin-F precursor - Homo sapiens (Human) - CST7 gene & protein

Belongs to the cystatin family.Curated. Keywords - Domaini. Signal. Phylogenomic databases. evolutionary genealogy of genes: ... "Structural basis of reduction-dependent activation of human cystatin F.". Schuettelkopf A.W., Hamilton G., Watts C., van Aalten ... "Structural basis of reduction-dependent activation of human cystatin F.". Schuettelkopf A.W., Hamilton G., Watts C., van Aalten ... "Structural basis of reduction-dependent activation of human cystatin F.". Schuettelkopf A.W., Hamilton G., Watts C., van Aalten ...
more infohttps://www.uniprot.org/uniprot/O76096

CYSTATIN C-BASED EQUATION (2012) | National Kidney FoundationCYSTATIN C-BASED EQUATION (2012) | National Kidney Foundation

cysC (cystatin C) = mg/L. Assays. *The cystatin-C based equation utilizes the Siemens (Date Behring) method and is not yet ... CYSTATIN C-BASED EQUATION (2012). eGFR =. 70.69 x (cysC)-0.931. Abbreviations / Units. eGFR (estimated glomerular filtration ... May serve as a reasonable alternative to the multivariate cystatin C equation when there is a concern about one of the major ... Grubb A, Blirup-Jensen S, Lindstrom V, Schmidt C, Althaus H, Zegers I. First certified reference material for cystatin C in ...
more infohttps://www.kidney.org/content/cystatin-c-based-equation-2012

Cystatin C, eGFR, Creatinine, and More - AACC.orgCystatin C, eGFR, Creatinine, and More - AACC.org

Home // ... // Clinical Laboratory News // CLN Stat // Cystatin C, eGFR, Creatinine, and More ... The principal advantage of cystatin C, Miller said, is for use in children and older adults, in whom creatinine-based eGFR is ... The 2012 Kidney Disease Improving Global Outcomes guidelines added a recommendation to also use cystatin C when calculating an ... "The laboratory challenge is that not all commercial methods for measuring cystatin C have calibration traceable to the ...
more infohttps://www.aacc.org/publications/cln/cln-stat/2016/july/12/cystatin-c-egfr-creatinine-and-more.aspx

cystatin A (stefin A) ELISA Kits | Biocompare.comcystatin A (stefin A) ELISA Kits | Biocompare.com

Compare cystatin A (stefin A) ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews ... Your search returned 48 cystatin A (stefin A) ELISA ELISA Kit across 6 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-1013640/Assay_Kit/ELISA_cystatin_A_stefin_A

Cystatin B Antibody
                
                
		        
	Cystatin B Antibody

Cystatin B Polyclonal Antibody from Invitrogen for Western Blot, Immunofluorescence and Immunohistochemistry (Paraffin) ... Protein Aliases: CPI-B; CST6; CSTB; cystatin B (stefin B); cystatin beta; Cystatin-B; Cystatin-beta; Liver thiol proteinase ... Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin ... Cite Cystatin B Polyclonal Antibody. The following antibody was used in this experiment: Cystatin B Polyclonal Antibody from ...
more infohttps://www.thermofisher.com/antibody/product/Cystatin-B-Antibody-Polyclonal/PA5-36076

Preinterventional Cystatin C: A Highly Prognostic Marker for All-Cause Mortality after CoronarographyPreinterventional Cystatin C: A Highly Prognostic Marker for All-Cause Mortality after Coronarography

in the fourth cystatin C quartile (,1.6 mg/L) compared with the lowest quartile, 5.38, 95% confidence interval 2.329-12.427 (. ... Cystatin C (CyC) and serum creatinine (SCr) are used as marker of renal function. A series of studies in the recent years have ... M. Madero, M. J. Sarnak, and L. A. Stevens, "Serum cystatin C as a marker of glomerular filtration rate," Current Opinion in ... M. G. Shlipak, C. L. W. Fyr, G. M. Chertow et al., "Cystatin C and mortality risk in the elderly: the health, aging, and body ...
more infohttps://www.hindawi.com/journals/an/2014/510209/

The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin | SpringerLinkThe structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin | SpringerLink

... ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the ... Yang X, Liu J, Yue Y, Chen W, Song M, Zhan X, Wu Z (2014) Cloning, expression and characterisation of a type II cystatin from ... Staun-Ram E, Miller A (2011) Cathepsins (S and B) and their inhibitor Cystatin C in immune cells: modulation by interferon-beta ... Here, we describe and characterize a novel immunomodulatory cystatin, Iristatin, which is upregulated in the salivary glands of ...
more infohttps://link.springer.com/article/10.1007%2Fs00018-019-03034-3
  • L68Q protein deposits in human cystatin C amyloid angiopathy patients have also been found in tissues outside of the brain including the testis, suggesting possible effects on fertility. (lu.se)
  • Results: Spermatozoa from mice expressing human L68Q cystatin C exhibit fertility defects and increased levels of amyloid. (lu.se)
  • Conclusion: L68Q epididymal fluid containing cystatin C amyloid is harmful for sperm function. (lu.se)
  • Examination of the epididymal fluid and spermatozoa from L68Q mice showed increased levels and distinct forms of cystatin C amyloid that were not present in WT mice. (lu.se)
  • L68Q epididymal fluid that was depleted of cystatin C amyloids, however, did not impair the motility of WT spermatozoa. (lu.se)
  • FRIDAY, Sept. 22, 2017 (HealthDay News) - Serum cystatin C level is an excellent predictor of mortality in patients with cirrhotic ascites, according to a study published online Sept. 14 in the Journal of Gastroenterology and Hepatology . (physiciansweekly.com)
more