A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
An autosomal dominant hereditary disease that presents in late in life and is characterized by DYSPHAGIA and progressive ptosis of the eyelids. Mutations in the gene for POLY(A)-BINDING PROTEIN II have been associated with oculopharyngeal muscular dystrophy.
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
The muscles of the PHARYNX are voluntary muscles arranged in two layers. The external circular layer consists of three constrictors (superior, middle, and inferior). The internal longitudinal layer consists of the palatopharyngeus, the salpingopharyngeus, and the stylopharyngeus. During swallowing, the outer layer constricts the pharyngeal wall and the inner layer elevates pharynx and LARYNX.
A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A class of nongenotoxic CARCINOGENS that induce the production of hepatic PEROXISOMES and induce hepatic neoplasms after long-term administration.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
A thermostable extracellular metalloendopeptidase containing four calcium ions. (Enzyme Nomenclature, 1992) 3.4.24.27.
A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.
Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.
A vinyl polymer made from ethylene. It can be branched or linear. Branched or low-density polyethylene is tough and pliable but not to the same degree as linear polyethylene. Linear or high-density polyethylene has a greater hardness and tensile strength. Polyethylene is used in a variety of products, including implants and prostheses.
A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Treatment using irradiation with LASER light of low power intensity so that the effects are not due to heat, as they are in LASER THERAPY.

Selective incorporation and specific cytocidal effect as the cellular basis for the antimelanoma action of sulphur containing tyrosine analogs. (1/130)

Tyrosine analogs are good candidates for developing melanoma chemotherapy because melanogenesis is inherently toxic and uniquely expressed in melanocytic cells. Sulphur containing substrate (tyrosine) analogs, N-acetyl-4-S-cysteaminylphenol (NAcCAP) and N-propionyl-4-S-cysteaminylphenol (NPrCAP), have been shown to have potent antimelanoma activity in mice bearing melanoma. Both NAcCAP and NPrCAP show selective cytotoxicity towards melanoma cell lines. But the mechanism leading to selectivity is not clear as these drugs are also toxic to other cell lines to a lesser extent. Here we show that these drugs have both cytostatic and cytocidal effects, which could account for this. Cytostatic effect is suggested by DNA flow cytometry. The drug causes cell cycle changes in four human cell lines (normal skin fibroblasts, HeLa cells, and melanoma cell lines, C32 and SK-MEL-23) in a dose-dependent manner blocking cells in S phase with concomitant decrease in the number of cells in G1 phase. There is also a gradual decrease in cells in G2 + M phases. The dose-concentration curves give IC50 values in the range of 50-400 microM and the melanotic melanoma cell line SK-MEL-23 has the lowest IC50 value consistent with our hypothesis that these drugs are selective towards melanoma cells. The concentration-dependent accumulation of cells in S phase suggest a cytostatic effect as a consequence of inhibition of DNA synthesis in agreement with [3H] thymidine incorporation assay. There is a highly specific uptake of [14C]NAcCAP and irreversible damage to DNA synthesis machinery in SK-MEL-23 cells, indicating a melanotic-specific cytocidal effect as well. Trypan blue exclusion study and competitive inhibition assay indicated that visible cytocidal effect occurs slowly and oxidative stress resulting from tyrosinase mediated oxidation of the drug appears to be the underlying mechanism. The primary antimelanoma effect of cysteaminylphenols derives from a selective cytostatic effect, but is followed by a specific cytocidal action rendering the drugs useful for targeted melanoma chemotherapy.  (+info)

Inhibition of melanin synthesis by cystamine in human melanoma cells. (2/130)

In studies to determine whether pigmentation can be regulated physiologically by thiols, human melanoma cells (MM418c5) and melanocytes were found to become depigmented when cultured continuously in 50 microM cystamine. Cystamine was depleted from the culture medium and the treatment was nontoxic and reversible. Cysteamine, dithiothreitol, and phenylthiourea were less effective, and glutathione, cysteine, and cystine were inactive. Tyrosinase (dopa oxidase) activity was not greatly affected except for induction of a lag period. In contrast, tyrosinase activity in an amelanotic melanoma cell line (MM96L) was rapidly inhibited without consumption of cystamine/cysteamine, in association with the generation of free thiol in the culture medium, and could be enhanced by the cystine transport inhibitor, glutamate. Tyrosinase expressed by a recombinant vaccinia virus was inhibited by cystamine treatment of MM96L and HeLa cells. Cystamine treatment lowered the degree of cross-linking of the pigmentation antigen gp75/TRP-1 in MM418c5 cells. Tyrosinase protein and mRNA levels in MM418c5 cells were not affected by cystamine. The results show that cystamine at a concentration close to physiologic levels has multiple effects on the melanogenic pathway. In amelanotic cells, tyrosinase has a short half-life and is readily inhibited by cystamine/cysteamine whereas tyrosinase in the more mature melanosomes of the pigmented cell appears to be less accessible to proteolytic and thiol attack. Inhibition of melanin synthesis in the latter cell type may arise to a significant degree from reduction of cystamine to cysteamine, which sequesters quinones.  (+info)

Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. (3/130)

Capacitance measurements were used to investigate the molecular mechanisms by which imidazoline compounds inhibit glucagon release in rat pancreatic alpha-cells. The imidazoline compound phentolamine reversibly decreased depolarization-evoked exocytosis >80% without affecting the whole-cell Ca(2+) current. During intracellular application through the recording pipette, phentolamine produced a concentration-dependent decrease in the rate of exocytosis (IC(50) = 9.7 microm). Another imidazoline compound, RX871024, exhibited similar effects on exocytosis (IC(50) = 13 microm). These actions were dependent on activation of pertussis toxin-sensitive G(i2) proteins but were not associated with stimulation of ATP-sensitive K(+) channels or adenylate cyclase activity. The inhibitory effect of phentolamine on exocytosis resulted from activation of the protein phosphatase calcineurin and was abolished by cyclosporin A and deltamethrin. Exocytosis was not affected by intracellular application of specific alpha(2), I(1), and I(2) ligands. Phentolamine reduced glucagon release (IC(50) = 1.2 microm) from intact islets by 40%, an effect abolished by pertussis toxin, cyclosporin A, and deltamethrin. These data suggest that imidazoline compounds inhibit glucagon secretion via G(i2)-dependent activation of calcineurin in the pancreatic alpha-cell. The imidazoline binding site is likely to be localized intracellularly and probably closely associated with the secretory granules.  (+info)

Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. (4/130)

Retinoids exert antiproliferative and prodifferentiating effects in vascular smooth muscle cells (SMCs) and reduce neointimal mass in balloon-injured blood vessels. The mechanisms through which retinoids carry out these effects are unknown but likely involve retinoid receptor-mediated changes in gene expression. Here we report the cloning, chromosomal mapping, and biological activity of the retinoid-response gene rat tissue transglutaminase (tTG). Northern blotting studies showed that tTG is rapidly and dose-dependently induced in a protein synthesis-independent manner after stimulation with the natural retinoid all-trans retinoic acid (atRA). The induction of tTG was selective for atRA and its stereoisomers 9-cis and 13-cis RA, because little or no elevation in mRNA expression was observed with a panel of growth factors. Western blotting and immunofluorescence confocal microscopy showed an accumulation of cytosolic tTG protein after atRA stimulation. Radiolabeled cross-linking studies revealed a corresponding elevation in in vitro tTG activity. The increase in tTG activity was reduced in the presence of 2 distinct inhibitors of tTG (monodansylcadaverine and cystamine). atRA-induced tTG mRNA and protein expression were followed by a significant elevation in SMC apoptosis. Such retinoid-induced programmed cell death could be partially inhibited with each tTG inhibitor and was completely blocked when both inhibitors were used simultaneously. These results establish a role for atRA in the sequential stimulation of tTG and apoptosis in cultured SMCs. atRA-mediated apoptosis in SMCs seems to require the participation of active tTG, suggesting a potential mechanistic link between this retinoid-inducible gene and programmed cell death.  (+info)

Catalytic selenols couple the redox cycles of metallothionein and glutathione. (5/130)

Co-ordination of zinc to the thiol group of cysteine allows mobilization of zinc through oxidation of its ligand. This molecular property links the binding and release of zinc in metallothionein (MT) to the cellular redox state [Maret W. & Vallee B.L. (1998) Proc. Natl Acad. Sci. USA 95, 3483-3488]. Biological disulfides such as glutathione disulfide (GSSG) oxidize MT with concomitant release of zinc, while glutathione (GSH) reduces the oxidized protein to thionein, which then binds to available zinc. Neither of these two redox processes is very efficient, even at high concentrations of GSSG or GSH. However, the GSH/GSSG redox pair can efficiently couple with the MT/thionein system in the presence of a selenium compound that has the capacity to form a catalytic selenol(ate). This coupling provides a very effective means of modulating oxidation and reduction. Remarkably, selenium compounds catalyze the oxidation of MT even under overall reducing conditions such as those prevailing in the cytosol. In this manner, the binding and release of zinc from zinc-thiolate co-ordination sites is linked to redox catalysis by selenium compounds, changes in the glutathione redox state, and the availability of either a zinc donor or a zinc acceptor. The results also suggest that the pharmacological actions of selenium compounds in cancer prevention and other antiviral and anti-inflammatory therapeutic applications, as well as unknown functions of selenium-containing proteins, may relate to coupling between the thiol redox state and the zinc state.  (+info)

Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form. (6/130)

Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The existence of a modifier subunit in invertebrates has not been described to date. We now demonstrate that GCL from Drosophila melanogaster has a functional modifier subunit (DmGCLM). A putative DmGCLM was obtained as an expressed sequence tag with 27% identity to human GCLM at the amino acid level. D. melanogaster GCLC (DmGCLC) and the candidate DmGCLM were expressed separately in Escherichia coli, purified, mixed, and then subjected to gel filtration, where they eluted as an approximately 140-kDa complex. DmGCLC co-immunoprecipitated with DmGCLM from S2 cell extracts, suggesting that they also associate in vivo. Enzyme kinetic analyses showed that DmGCLC has a K(m) for glutamate of 2.88 mm, but when complexed with DmGCLM, the K(m) for glutamate is 0.45 mm. Inhibition of DmGCLC activity by glutathione was found to be competitive with respect to glutamate (K(i) = 0.03 mm), whereas inhibition of the GCL complex was mixed (K(i) = 0.67 mm), suggesting allosteric effects. In accordance with this, DmGCLC and DmGCLM have the ability to form reversible intermolecular disulfide bridges. A further mechanism for control of D. melanogaster GCL was found to be induction of DmGCLC by tert-butylhydroquinone in S2 cells. DmGCLM levels were, however, unaffected by tert-butylhydroquinone.  (+info)

Dimethylnitrosamine-induced inhibition of hepatic protein synthesis in vitro and the effect of pretreatment with cystamine or pregnenolone-16alpha-carbonitrile. (7/130)

Hepatic protein synthesis was investigated using a postmitochondrial supernatant system derived from the livers of rats that were given injections of a single dose of dimethylnitrosamine (DMN), 30 mg/kg. The time course and extent of DMN-induced inhibition in vitro were identical to those reported for the incorporation of amino acids into liver proteins in vivo, maximum inhibition being about 70% at 5 hr. Addition of specific inhibitors of chain initiation (polyinosinic acid and aurin tricarboxylic acid) to the postmitochrondrial supernatant system from DMN-treated rats caused only a slight additional inhibition, indicating that DMN predominantly affects translation by a block of initiation. Treatment with cystamine prior to DMN administration completely abolished the depression of protein synthesis and reduced by more than 90% the methylation by [14C]DMN of purine bases in liver DNA. Pretreatment with pregnenolone-16alpha-carbonitrile stimulated protein synthesis in controls but had no preventive effect in DMN-treated rats and did not reduce the extent of DNA alkylation in vivo.  (+info)

Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens. (8/130)

The effects of irreversible alpha1-adrenoceptor antagonists, SZL-49 (an alkylating analogue of prazosin), dibenamine and benextramine on contractions to noradrenaline (NA) in longitudinal and circular muscle of human epididymal vas deferens were investigated. Competitive alpha1-adrenoceptor antagonists were also used to further characterize the alpha1-adrenoceptor subtype stimulated by NA in longitudinal and circular muscle. NA evoked concentration-dependent contractions of both muscle types (pD2; 5.4 and 5.2 respectively). The contraction of circular muscle was comparatively more sensitive than that of longitudinal muscle to pretreatment with SZL-49. In contrast, dibenamine or benextramine produced comparable effects in both muscle types. The relationship between receptor occupancy and contraction in either longitudinal or circular muscle was nonlinear, with half-maximal response requiring similar receptor occupancy (longitudinal muscle 14%, circular muscle 16%). Maximal response in both muscle types occurred with little or no receptor reserve (<10%). The competitive alpha1-adrenoceptor antagonists produced dextral shifts of the dose-response curves to NA in longitudinal and circular muscle. The inhibitory potencies, estimated from the apparent pKB values were significantly different in longitudinal and circular muscle respectively for either WB 4101 (pKB, 8.6 and 9.5) or RS-17053 (pKB, 7.1 and 9.0) but not for Rec 15/2739 (pKB, 9.2 and 9.8) or HV 723 (pKB, 8.3 and 8.4). In conclusion, the potency profile of the competitive alpha1-adrenoceptor antagonists and the lack of different receptor reserves for NA in the muscle types suggest that the discriminatory effects of SZL-49 is primarily due to a predominance of the alpha1L-adrenoceptor subtype in longitudinal muscle and alpha1A-subtype in circular muscle.  (+info)

We have investigated the effects of cystamine on the replication of human immunodeficiency virus (HIV) in human lymphocytes and macrophages, the natural targets of HIV in vivo. Treatment of chronically infected macrophages with cystamine, at a concentration (500 microM) that did not show any cytotoxic or cytostatic effects, strongly decreased (, 80%) HIV-p24 antigen production and completely abolished the production of infectious viral particles. Cystamine does not affect viral transcription, translation or protein processing; indeed, all HIV proteins are present in a pattern similar to that of nontreated cells. Instead, cystamine interferes with the orderly assembly of HIV virions, as shown by electron microscopy analysis, that reveals only defective viral particles in treated cells. Moreover, suppression of HIV replication, due to the inhibition of proviral DNA formation was observed in acutely infected lymphocytes and macrophages pretreated with cystamine. These results show that cystamine ...
Abstract Cystamine has shown significant neuroprotective properties in preclinical studies of Parkinsons disease (PD) and Huntingtons disease (HD). Cysteamine, its FDA-approved reduced form, is scheduled to be tested for clinical efficacy in HD patients. Here, we studied the key cystamine metabolites, namely cysteamine, hypotaurine and taurine, as well as cysteine, in order to identify which one is more distinctively responsible for the neuroprotective action of cystamine. After a single administration of cystamine (10, 50 or 200 mg/kg), naïve mice were perfused with phosphate-buffered saline (PBS) at 1, 3, 12, 24 or 48 h post-injection and brain and plasma samples were analyzed by two distinct HPLC methods. Although plasma levels remained under the detection threshold, significant increases in cysteamine brain levels were detected with the 50 and 200 mg/kg doses in mice perfused 1 and 3 h following cystamine injection. To further assess cysteamine as the candidate molecule for pre-clinical ...
Page contains details about aurora A kinase specific small interfering RNA loaded cystamine/octanedioic acid/branched polyethyleneimine-modified hyaluronic acid micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Recombinant elastin-like protein (ELP) polymers display several favorable characteristics for tissue repair and replacement as well as drug delivery applications. However, these materials are derived from peptide sequences that do not lend themselves to cell adhesion, migration, or proliferation. This report describes the chemoselective ligation of peptide linkers bearing the bioactive RGD sequence to the surface of ELP hydrogels. Initially, cystamine is conjugated to ELP, followed by the temperature-driven formation of elastomeric ELP hydrogels. Cystamine reduction produces reactive thiols that are coupled to the RGD peptide linker via a terminal maleimide group. Investigations into the behavior of endothelial cells and mesenchymal stem cells on the RGD-modified ELP hydrogel surface reveal significantly enhanced attachment, spreading, migration and proliferation. Attached endothelial cells display a quiescent phenotype ...
As a model for understanding how protein disulfide isomerase (PDI) catalyzes disulfide bond formation in proteins, its action on a 28-residue disordered peptide containing only two cysteine residues has been examined. Disulfide formation in the peptide using the chemical reaction with small molecule thiol/disulfide reagents, such as oxidized and reduced glutathione or cystamine and cysteamine, occurs in two steps, via two alternative intermediate mixed disulfides between the reagent and either peptide cysteine residue. All thiol/disulfide forms of the peptide could be trapped and quantified, so the rates of their interconversion could be measured. Catalytic amounts of PDI increased the rates of these reactions. All rate enhancements were independent of the concentration of the peptide, indicating that it bound to PDI with an apparent K-m of less than 3 mu M. In the presence of glutathione, PDI accelerated the formation of both single mixed disulfide species, plus their subsequent rearrangement ...
Whitney, J B., Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. (1978). Faculty Research 1970 - 1979. 939 ...
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This study sought to reveal the relationship between Snap-25 and tetramine poisoning in order to approach the mechanism of tetramine poisoning. The levels of Snap-25 mRNA in the brain tissues of poisoned SD rats were detected by RT-PCR method. After 1 hour of intoxication, the expression level of Snap-25 mRNA did not change in the rat brain. It increased at day 1 and reached its peak at day 3. The expression level of Snap-25 mRNA begain to descend at day 5, but it was still higher than that in the rat brain tissue of control group. In this study the expression of Snap-25 of rat poisoned by tetramine was not markedly increased in the early stage of poisoning, indicating that the symptoms of rat poisoned by tetramine are not induced by the changes of the Snap-25 level. The mechanism of high expression in Snap-25 mRNA probably involves the negative feedback of the body, which may increase the releasing of neurohumor and hence mitigate the symptoms of poisoning.. ...
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0068]Patients with cystinosis are required to ingest oral cysteamine (Cystagon) every 6 hours, day and night. When taken regularly, cysteamine can deplete intracellular cystine by up to 90% (as measured in circulating white blood cells), and this has been shown to reduce the rate of progression to kidney failure/transplantation and also to obviate the need for thyroid replacement therapy. Unfortunately, because of the strict treatment regimen and the associated symptoms, nonadherence with cysteamine therapy remains a problem, particularly among adolescent and young adult patients. Certainly, by reducing the frequency of required cysteamine dosing adherence can be improved. The disclosure shows a strong statistical association between the maximum plasma concentration (Cmax) of cysteamine and AOC measurements for leukocyte cystine (P,0.001). A higher Cmax is achieved after delivery of cysteamine into the small intestine than when infused into the stomach or colon; this may be due to improved ...
TY - JOUR. T1 - Effects of transglutaminase 2 inhibition on ventilator-induced lung injury. AU - Suh, In Bum. AU - Yoon, Dae Wui. AU - Oh, Won-Oak. AU - Lee, Eun Joo. AU - Min, Kyung-Hoon. AU - Hur, Gyu Young. AU - Lee, Seung Heon. AU - Lee, Sung Yong. AU - Lee, Sang Yeub. AU - Shin, Chol. AU - Shim, Jae Jeong. AU - In, Kwang Ho. AU - Kang, Kyung Ho. AU - Kim, Je Hyeong. PY - 2014/1/1. Y1 - 2014/1/1. N2 - This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV) group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI) group; and 6) LPV with cystamine pretreatment (Cyst+LPV) group. Acute lung injury (ALI) score, TG2 activity and gene expression, inflammatory cytokines, and nuclear factor-κB (NF-κB) activity were measured. TG2 activity and gene expression were ...
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Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and visceral organs and vascular alterations. SSc pathophysiology involves systemic inflammation and oxidative stress. Because the vanin-1 gene (vnn1) encodes an enzyme with pantetheinase activity that converts vasculoprotective pantethine into profibrotic pantothenic acid and pro-oxidant cystamine, we tested this pathway in the pathophysiology of SSc. Activation of the vanin-1/pantetheinase pathway was investigated in wild-type BALB/c mice with hypochlorous acid (HOCl)-induced SSc by ELISA and Western blotting. We then evaluated the effects of the inactivation of vnn1 on the development of fibrosis, endothelial alterations, and immunological activation in mice with HOCl- and bleomycin-induced SSc. We then explored the vanin-1/pantetheinase pathway in a cohort of patients with SSc and in controls. In wild-type mice with HOCl-induced SSc, the vanin-1/pantetheinase pathway was dysregulated, with elevation of ...
We found out the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 (HSV-2) was 2. followed by complete recovery and unpredictable recurrences. The disease is most often caused by herpes simplex virus type 2 (HSV-2) and less frequently by other viruses autoimmune disorders or medication. Symptomatic episodes of RLM usually subside within 5 years but the total number of episodes may reach 30. Patients are typically middle-aged and women are more often affected than men (1-3). In addition to symptoms typical of meningitis ≈50% of patients have transient hallucinations seizures cranial nerve palsies or an altered level of consciousness (4). The Study This study Biotinyl Cystamine was conducted at Helsinki University Central Hospital Finland which serves a population of 1 1.4 million. The prevalence study covered January 1996 through December 2006. This period differed from that of the patient research because the Globe Wellness Organizations coding program ...
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Hexamethylene tetramine derivatives of alkali lignins are formed by reacting, at a temperature between 70° C. and 180° C., 0.17 to 2.0 moles of a hexamethylene tetramine forming solution with 1 mole o
1. Rat erythrocytes were fused by incubation with benzyl alcohol and Ca2+. 2. Cell fusion was inhibited by EGTA, N-ethylmaleimide, tetrathionate, iodoacetamide, cystamine, Tos-Lys-CH2Cl, and to a lesser extent by Tos-Phe-CH2Cl. Phenylmethanesulphonyl fluoride, Tos-Arg-OMe and histamine did not inhibit cell fusion. 3. Gel electrophoresis of membrane proteins from ghosts of the erythrocytes treated with benzyl alcohol showed that a high-molecular-weight polymer was present: this was consistent with the entry into the cells of Ca2+ and the activation of a transglutaminase enzyme. 4. In the treated cells the proteins corresponding to bands 2 and 3 in human erythrocytes were decreased, and a polypeptide with a slightly greater mobility than band 3 was produced. 5. These changes were inhibited by EGTA, N-ethylmaleimide, tetrathionate, iodoacetamide, cystamine, and Tos-Lys-CH2Cl, but not by phenylmethanesulphonyl fluoride, Tos-Arg-OMe, or histamine. 6. The intramembraneous particles of the P-fracture ...
Vijayan, Kalyani and Vedavathi, BM and Mani, A (1993) Structural evidence for the radical scavenging mechanism of some aminothiol group of radioprotectants. Chemical Sciences, 92 (4 amp;). pp. 457-462. Vedavathi, BM and Mani, A and Vijayan, Kalyani (1982) Crystal data on L-epinephrine bydrochloride monohydrate. Current Science, 51 (9). p. 466. Mani, A and Vedavathi, BM and Vijayan, Kalyani (1982) Crystal data on the radioprotectants,N-(2-Mercaptoprofionyl13; ) cycline and N.N.N,N,-Tetramethyl-1,4-Phenylene diamine-dihydrochloride. Current Science, 51 (4). p. 192. Vedavathi, BM and Vijayan, Kalyani (1979) The crystal and structure of the radioprotectant cystamine dhydrochloride. Current science, 48 (23). pp. 1028-1030. Vedavathi, BM and Vijayan, Kalyani (1979) 2-Amino-1,3-thiazoline hydrochloride. Acta Crystallography (B37). pp. 477-480. ISSN 0567.7408 Vedavathi, BM and Vijayan, Kalyani (1976) Radioprotectant Sodium Fluoroacetate. Acta Crystallography. pp. 946-948. ...
TY - JOUR. T1 - A novel hindered macrocyclic tetramine containing two bispidine units. A new type of proton sponge. AU - Miyahara, Yuji. AU - Goto, Kenta. AU - Inazu, Takahiko. PY - 2001/4/23. Y1 - 2001/4/23. N2 - A novel cyclam-like macrocyclic tetramine 1a was synthesized via coupling of bispidine and its bis(α-chloroacetamide) followed by reduction. Strongly basic but encrypted nitrogens of 1a were found to abstract a proton from chloroform to form dichlorocarbene.. AB - A novel cyclam-like macrocyclic tetramine 1a was synthesized via coupling of bispidine and its bis(α-chloroacetamide) followed by reduction. Strongly basic but encrypted nitrogens of 1a were found to abstract a proton from chloroform to form dichlorocarbene.. UR - http://www.scopus.com/inward/record.url?scp=0035938320&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0035938320&partnerID=8YFLogxK. U2 - 10.1016/S0040-4039(01)00341-0. DO - 10.1016/S0040-4039(01)00341-0. M3 - Article. AN - ...
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Synthesis and Enantioselectivity of Optically Active 1-and 3-Substituted 4-Phenyl-1, 2, 3, 4-tetrahydroisoquinolin-4-ols and Related Compounds as Norepinephrine Potentiators (1995 ...
TY - JOUR. T1 - Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery. AU - Christensen, Lane V.. AU - Christensen, L.. AU - Chang, Chien-Wen. AU - Kim, Won Jong. AU - Kim, Sung Wan. AU - Zhong, Zhiyuan. AU - Lin, C.. AU - Engbersen, Johannes F.J.. AU - Feijen, Jan. PY - 2006. Y1 - 2006. N2 - Poly(amido ethylenimine) polymers, a new type of peptidomimetic polymer, containing multiple disulfide bonds (SS-PAEIs) designed to degrade after delivery of plasmid DNA (pDNA) into the cell were synthesized and investigated as new carriers for triggered intracellular gene delivery. More specifically, three SS-PAEIs were synthesized from Michael addition reactions between cystamine bisacrylamide (CBA) and three different ethylene amine monomers, i.e., ethylenediamine (EDA), diethylenetriamine (DETA), or triethylenetetramine (TETA). Complete addition reactions were confirmed by 1H NMR. The molecular weight, buffer capacity, and relative degree of branching for each SS-PAEI ...
The present invention relates to a DNA fragment having a gene derived from fish which codes for a polypeptide possessing transglutaminase activity, a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase, a transformant into which a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase is introduced, and a method for the production of a transglutaminase, comprising culturing a transformant containing a fish-derived DNA fragment which codes for a transglutaminase.
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Like F508del-CFTR, A561E-CFTR perturbs protein processing, thermostability and channel gating. CFTR potentiators partially restore channel function to low temperature-rescued A561E-CFTR. Transformational drug therapy for A561E-CFTR is likely to require CFTR correctors, CFTR potentiators and special …
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sp:TGM3_MOUSE] Tgm3, AI893889, TG_E, TG(E), TGE, TGase_E, TGase-3, we; transglutaminase 3, E polypeptide; K05620 transglutaminase 3 [EC:2.3.2.13] ...
sp:TGM3_MOUSE] Tgm3, AI893889, TG_E, TG(E), TGE, TGase_E, TGase-3, we; transglutaminase 3, E polypeptide; K05620 transglutaminase 3 [EC:2.3.2.13] ...
xtr:100145475 K05620 transglutaminase 3 [EC:2.3.2.13] , (RefSeq) tgm6; transglutaminase 6 (A) MRSDPQVIACDWYYAVNEKAHHTDVYESDDLVLRRGQPFKLTLMLNRPLQAEENILFIFE TGPSPSETSKTKVVFPLFRAENLQSWGAILTSIKSTSITVTINSHSDAVIGRYILSVAVQ CRGSDKPLPHQIGALNLLFNPWLQGDAVFMAEEDQRQEYVMNEQGVIFQGSDEDITSINW EYNQFERNILDICLVILDRSQNYKKDPALDVSQRNDPLYVCRVLSAMLNSKGDDGVLEEN WSDDYINGASPSSWNGSMNILKSWYYSKFKPVKYGQCWVYAGMLCTVLRSLGIPTRVITH FNSGQDKNANLFIDLQYKSQGSRQNDQEDQLWNFHVWNEAYFKRRDLGKSYNGWQVIDST PLKRSDGVYQCGPAPLTAIKEGDINLNYDVKYMFASVNADVACWIYYRNGTKKQVSNNAK ETGKFISTKAIGSNDRVDVTNNYKYAKGSEKEIKVFEKALKLSKGSFVGRTREKPRGGNI LFGRCTLDQIATFGQDFNLILSLKNLTPDSINVTVYINTSAILYTGRQRHTIWTGGKFLS LGPNLEKRFSIPVKYGQYSKHMTDNGVICMTALCEVEGTEERILVERNVSLVKPPLSITL PDKAIINQESNANIVIVNPLLETLNSCILWVEGYGLTDKILKKEVPSLKPGQSSEHNFVI TPMKTGVRTLLVNFSCDKIQNMKGSGKILITYSQEVSDSPVPT ...
Vascular aging is marked by an increase in vascular stiffness. Tissue-type transglutaminase (tTG) enzymatically forms crosslinks between extracellular matrix proteins and may contribute to this pathobiology. Recently, it has been demonstrated that s-nitrosylation of cysteine residues within the enzyme leads to its inhibition. We hypothesize that tTG is more active in the aging vasculature due to decreased bioavailability of nitric oxide (NO) and impaired S-nitrosylation. tTG activity in aorta measured by the incorporation of biotin labeled pentylamine, a tTG substrate, into crosslinks was markedly increased in old (O) animals compared to young (Y) (3.2 fold increase, n = 6, p = 0.0018). S-nitrosylation of tTG, as determined by the biotin switch assay, was significantly reduced in O vs. Y rat aorta. tTG specific (ϵ-(γ-glutamyl)lysine) crosslinks measured by immunofluorescent staining was significantly increased in O vs Y rat aortic rings. Denitrosylation of tTG in Y rats with DTT increased tTG ...
ABSTRACT: Human cystinotic fibroblasts were completely depleted of their accumulated intracellular free cystine within a 2-h time interval when exposed to culture medium containing between 1 and 5 mM mercaptoethylgluconamide. This cystine-depleting action of mercaptoethylgluconamide was observed with three different human cystinotic fibroblast cell lines and with all three cell lines, 2 mM mercaptoethylgluconamide was as effective as 1 mM cysteamine in depleting cells of their intracellular free cystine. Cell viability was excellent for cystinotic fibroblasts exposed to 2 mM mercaptoethylgluconamide for up to 6 days in duration. Mercaptoethylgluconamide (2 mM) was sufficiently stable under cell culture conditions such that a single addition of mercaptoethylgluconamide maintained cystine depletion in human cystinotic fibroblasts for at least a 4-day period. In contrast to cysteamine, 2 mM mercaptoethylgluconamide was not capable of depleting the cystine content of isolated cystinotic lysosomes, implying
TY - JOUR. T1 - Importance of tissue transglutaminase in repair of extracellular matrices and cell death of dermal fibroblasts after exposure to a solarium ultraviolet A source. AU - Gross, Stephane R.. AU - Balklava, Zita. AU - Griffin, Martin. PY - 2003/7/23. Y1 - 2003/7/23. N2 - Investigations were undertaken to study the role of the protein cross-linking enzyme tissue transglutaminase in changes associated with the extracellular matrix and in the cell death of human dermal fibroblasts following exposure to a solarium ultraviolet A source consisting of 98.8% ultraviolet A and 1.2% ultraviolet B. Exposure to nonlethal ultraviolet doses of 60 to 120 kJ per m2 resulted in increased tissue transglutaminase activity when measured either in cell homogenates, in situ by incorporation of fluorescein-cadaverine into the extracellular matrix or by changes in the epsilon(gamma-glutamyl) lysine cross-link. This increase in enzyme activity did not require de novo protein synthesis. Incorporation of ...
The present invention relates to use of a transglutaminase in the preparation of a medicament for inhibiting angiogenesis. Preferably, the transglutaminase is a human tissue transglutaminase. Advantageously, the medicament is for treating cancer, rheumatoid arthritis, retinopathy and/or psoriasis. Additionally, the invention relates to compositions comprising a transglutaminase in an amount sufficient to inhibit angiogenesis.
A tissue transglutaminase (TTG) IgA and/or IgG test is used as part of an evaluation for certain autoimmune conditions, most notably celiac disease.
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0101]Particularly advantageous antioxidants are chosen from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (e.g. urocanic acid) and derivatives thereof, peptides such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (e.g. anserine), carotenoids, carotenes (e.g. alpha.-carotene, β-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. ...
We studied the role of K+ channels and Na+,K+-ATPase in the presynaptic inhibitory effects of prostaglandin E1 (PGE1) and PGE2 on the adrenergic responses of human vas deferens. Furthermore, we determined the effects of increasing extracellular K+ concentrations ([K+]o) and inhibition of Na+,K+- ATPase on neurogenic and norepinephrine-induced contractile responses. Ring segments of the epididymal part of the vas deferens were taken from 45 elective vasectomies and mounted in organ baths for isometric recording of tension. The neuromodulatory effects of PGEs were tested in the presence of K+ channel blockers. PGE1 and PGE2 (10_8 to 10_6 M) induced inhibition of adrenergic contractions. The presence of tetraethylammonium (10_3 M), charybdotoxin (10_7 M), or iberiotoxin(10_7 M), prevented the inhibitory effects of PGE1 and PGE2 on the adrenergic contraction. Botx glibenclamide (10_5 M) and apamin (10_6 M) failed to antagonize PGE1 and PGE2 effects. Raising the [K+]o from 15.8 mM to 25.8 mM caused ...
Lab Reagents Tissue Laboratories manufactures the tissue transglutaminase reagents distributed by Genprice. The Tissue Transglutaminase reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Tissue. Other Tissue products are available in stock. Specificity: Tissue Category: Transglutaminase. Lab Tools information ...
TY - JOUR. T1 - Tissue transglutaminase and the progression of human renal scarring. AU - Johnson, Timothy S.. AU - El-Koraie, Ahmed F.. AU - Skill, N.. AU - Baddour, Nahed M.. AU - El Nahas, A. Meguid. AU - Njloma, Melvin. AU - Adam, Ahmed G.. AU - Griffin, Martin. PY - 2003/8/1. Y1 - 2003/8/1. N2 - Experimental renal scarring indicates that tissue transglutaminase (tTg) may be associated with the accumulation of extracellular matrix (ECM), both indirectly via TGF-β1 activation and directly by the formation of ε(γ-glutamyl) lysine dipeptide bonds within the ECM. The latter potentially accelerates deposition and confers the ECM with resistance to proteolytic digestion. Studied were 136 human renal biopsy samples from a range of chronic renal diseases (CRD) to determine changes in tTg and ε(γ-glutamyl) lysine crosslinking. Immunofluorescence for insoluble tTg showed a 14-fold increase in the kidneys of CRD patients (5.3 ± 0.5 versus 76 ± 54 mV/cm2), which was shown to be active by a ...
glutamate-cysteine ligase complex, enzyme regulator activity, glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, protein heterodimerization activity, aging, apoptotic mitochondrial changes, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus
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For CR, IIR, NBR, NR, SBR and EPDM; activator for nitrogen-type blowing agents; activator for thiazole, thiuram and dithiocarbamate accelerators; relatively nondiscoloring and non-staining; reduces odor-producing properties of dinitrosopentamethylene tetramine blowing agents; helps lower decomposition point of Celogen AZ and Kempore types to range normal for rubber curing. ...
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Recombinant Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM3) Protein. Species: Human. Order product ABIN1047977.
A transglutaminase é uma enzima que actua como catalisadora de reacções de ligações entre moléculas de proteína. Este tipo de ligações resultantes da acção desta enzima, são de grande estabilidade e ocorrem entre os aminoácidos glutamina e lisina. Sendo assim,...
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Lebo RV, Kredich NM (Apr 1978). "Inactivation of human gamma-glutamylcysteine synthetase by cystamine. Demonstration and ...
His thesis from 1954 treated metabolism of cystamine and cysteamine. He was a pioneer in the development of diagnostic methods ...
"Inhibition of melanin synthesis by cystamine in human melanoma cells". The Journal of Investigative Dermatology. 114 (1): 21-27 ...
McCarty MF (2001). "Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of ...
Borrell-Pagès M, Canals JM, Cordelières FP (2006). "Cystamine and cysteamine increase brain levels of BDNF in Huntington ...
It forms a three-dimensional hydrogel when cross-linked with N,N'-methylene-bis-acrylamide (MBAm) or N,N'-cystamine-bis- ...
The affinity of cystamine to DNA plays a role in the toxicity and radioprotecting properties of cystamine. Cystamine has also ... Cystamine is toxic if swallowed or inhaled and potentially harmful by contact. Cystamine is an organic disulfide which is ... "Cystamine - HOPES". web.stanford.edu. Retrieved 2017-03-17. Sharma, Rashmi (1995). "The uptake and metabolism of cystamine and ... At high concentrations cystamine induces an abnormal tubulin polymerization. Five cystamine molecules can bind covalently to ...
... is used as a crosslinker for the synthesis of a biodegradable cystamine spacer in PGA-cystamine-Gd-DO3A, ... Mono-BOC-cystamine (mono BOC protected cystamine ) is a tert-butyloxycarbonyl (BOC) derivative of cystamine used as crosslinker ... Mono-BOC-cystamine is used as a crosslinker for the synthesis of cleavable photo-cross-linking reagent. ... The disulfide chain allows the mono-BOC-cystamine to be easily cleaved, allowing removal of the tagging residue when desired. ...
13:30:53 (4, 4, 4) (EDIT) User:Beetstra (contribs, talk) edited Cystamine (diff, hist). Added: 'InChI' ('' -, '1/C4H12N2S2/c5-1 ... 13:30:52 (4, 4, 4) (EDIT) User:Beetstra (contribs, talk) edited Cystamine (diff, hist). Added: 'PubChem' ('' -, '2915', SET '') ... 13:30:53 (4, 4, 4) (EDIT) User:Beetstra (contribs, talk) edited Cystamine (diff, hist). Changed: 'SMILES' ('NCCSSCCN' -, 'S( ... 13:41:50 (5, 5, 5) (EDIT) User:CheMoBot (contribs, talk) edited Cystamine (diff, hist). Added: 'CASNo_Ref' ('' -, '{{cascite ...
The affinity of cystamine to DNA plays a role in the toxicity and radioprotecting properties of cystamine. Cystamine has also ... Cystamine is toxic if swallowed or inhaled and potentially harmful by contact. Cystamine is an organic disulfide which is ... "Cystamine - HOPES". web.stanford.edu. Retrieved 2017-03-17. Sharma, Rashmi (1995). "The uptake and metabolism of cystamine and ... At high concentrations cystamine induces an abnormal tubulin polymerization. Five cystamine molecules can bind covalently to ...
Mono-BOC-cystamine is used as a crosslinker for the synthesis of a biodegradable cystamine spacer in PGA-cystamine-Gd-DO3A, ... Mono-BOC-cystamine (mono BOC protected cystamine ) is a tert-butyloxycarbonyl (BOC) derivative of cystamine used as crosslinker ... Mono-BOC-cystamine is used as a crosslinker for the synthesis of cleavable photo-cross-linking reagent. ... The disulfide chain allows the mono-BOC-cystamine to be easily cleaved, allowing removal of the tagging residue when desired. ...
The present report deals with a series of experiments on the effects of cystamine, cysteamine and cysteine when added to ... Radioprotective Properties of Cystamine, Cysteamine and Cysteine when tested with Chick Fibroblasts in vitro *P. OFTEDAL1. , ... Protection of cells in tissue culture by means of cysteamine and cystamine against the action of nitrogen mustard and X-rays * ... The present report deals with a series of experiments on the effects of cystamine, cysteamine and cysteine when added to ...
Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells.. A Bergamini, M Capozzi ... Cystamine does not affect viral transcription, translation or protein processing; indeed, all HIV proteins are present in a ... Instead, cystamine interferes with the orderly assembly of HIV virions, as shown by electron microscopy analysis, that reveals ... We have investigated the effects of cystamine on the replication of human immunodeficiency virus (HIV) in human lymphocytes and ...
Cystamine does not affect viral transcription, translation or protein processing; indeed, all HIV proteins are present in a ... Instead, cystamine interferes with the orderly assembly of HIV virions, as shown by electron microscopy analysis, that reveals ... Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells.. ... Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells.. ...
Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy ... Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy ... Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy ... Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy ...
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative ... Cystamine and cystamine derivatives include sulfated cystamine. Enteric coatings prolong release until the cystamine, cystamine ... cystamine, wherein the cysteamine or cystamine is enterically coated. [0044] The cysteamine or cystamine is present in the ... 0006] The invention provides a composition comprising an enterically coated cystamine or cystamine derivative. [0007] The ...
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We tested whether cystamine could have such properties in a Parkinsons disease murine model and now provide evidence that it ... Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinsons ... Importantly, we report that cystamine has neurorestorative properties 5weeks post-lesion as seen on the number of nigral ... The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical ...
Definition of the term Cystamine Dihydrochloride: A radiation-protective agent that interferes with sulfhydryl enzymes. It may ... cystamine sulfate, cystamine hydrochloride, cystamine hydrobromide, cystamine dihydrobromide, cystamine diacetate, cystamine ... Cystamine Dihydrochloride: A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against ... Terms Related to Cystamine Dihydrochloride. *. Trichlorobromomethane. A potent liver poison. In rats, bromotrichloromethane ...
Cystamine and cystamine derivatives include sulfated cystamine. Enteric coatings prolong release until the cystamine, cystamine ... enterically coated cystamine or cystamine derivative releases the cystamine or cystamine derivative when the composition ... cystamine, wherein the cysteamine or cystamine is enterically coated. [0044]The cysteamine or cystamine is present in the ... 8. A composition comprising:an enterically coated cystamine or cystamine derivative. 9. The composition of claim 8, wherein an ...
Comparison between cystamine-sensitive and cystamine-resistant cell lines revealed that cystamine cytotoxicity is not ... Comparison between cystamine-sensitive and cystamine-resistant cell lines revealed that cystamine cytotoxicity is not ... Comparison between cystamine-sensitive and cystamine-resistant cell lines revealed that cystamine cytotoxicity is not ... Comparison between cystamine-sensitive and cystamine-resistant cell lines revealed that cystamine cytotoxicity is not ...
Amelioration of CCl4-induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine ... Amelioration of CCl4-induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine ... Amelioration of CCl4-induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine ... Amelioration of CCl4-induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine ...
HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels ... be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. ...
Keywords: cystamine; cystathionine γ-lyase (γ-cystathionase); garlic; glutathione persulfide; hydrogen sulfide; mercaptoethanol ... perseleno selenium; persulfide; sulfane sulfur; thioglycerol cystamine; cystathionine γ-lyase (γ-cystathionase); garlic; ...
Animals , Cystamine/pharmacology , Female , Lipid Metabolism , Liver/metabolism , Microsomes, Liver/metabolism , Mitochondria, ... Cystamine / Lipid Metabolism / Liver / Animals Language: English Journal: Indian J Biochem Biophys Year: 1980 Type: Article ... Cystamine / Lipid Metabolism / Liver / Animals Language: English Journal: Indian J Biochem Biophys Year: 1980 Type: Article ...
Page contains details about aurora A kinase specific small interfering RNA loaded cystamine/octanedioic acid/branched ... paclitaxel loaded cystamine/octanedioic acid/branched polyethyleneimine-modified hyaluronic acid micelles. *aurora A kinase ... aurora A kinase specific small interfering RNA loaded cystamine/octanedioic acid/branched polyethyleneimine-modified hyaluronic ... aurora A kinase specific small interfering RNA loaded cystamine/octanedioic acid/branched polyethyleneimine-modified hyaluronic ...
Inhibition of Sickling by Cystamine. Progress in Interpreting the Phase Transitions of Sickle-Cell Hemoglobin. Circular ... cystamine inhibition of sickling, and gelation of sickle cell hemoglobin. This volume is organized into 52 chapters and begins ...
Cystamine dihydrochloride (10 mg, 44 μmol; Sigma C 8707) was dissolved in 2.5 mL of 0.1 M MES pH 5.7 and adjusted to pH 5.75. ... Cystamine dihydrochloride (44 umol; Sigma C 8707) was dissolved in 2.5 ml of 0.1 M MES pH 5.7 and adjusted to pH 5.75. EDC (47 ... After 10 minutes, the cystamine solution was added and the pH was maintained between 5.5 and 5.8 while the reaction proceeded ... After 10 minutes, the cystamine solution was added and the pH was maintained between 5.5 and 5.8 while the reaction proceeded ...
B-D, Cystamine (1-100 μm) (B), B003 (100, 200 μm) (C), and D004 (25-100 μm) (D) protect primary immature cortical neurons ... A, B, Astrocytes are treated overnight with the TG inhibitors Cystamine (A) or B003 (B). Following washoff of the inhibitors, ... Indeed, addition of the cell-permeant TG inhibitors (cystamine 100 μm, B003 100 μm, D004 50 μm) up to 14-17 h after glutamate ... 2003) Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem 278:3825-3830 ...
... cystamine-co-1,6-hexanediol diacrylate-co-piperazine) nanoparticles in phosphate-buffered saline (pH 6.5) . It has composition ... 1 1 poly(D-α-tocopheryl polyethylene glycol 1000-2,2-bis(acryloyloxymethyl)propionate-co-N,N-bis(acryloyl)cystamine-co-1,6- ... poly(D-α-tocopheryl polyethylene glycol 1000-2,2-bis(acryloyloxymethyl)propionate-co-N,N-bis(acryloyl)cystamine-co-1,6- ... poly(D-α-tocopheryl polyethylene glycol 1000-2,2-bis(acryloyloxymethyl)propionate-co-N,N-bis(acryloyl)cystamine-co-1,6- ...
Humans , Male , Female , Glutathione Reductase/metabolism , Malaria/enzymology , Riboflavin/deficiency , Cystamine/therapeutic ... Glutathion reductase activity and its relation with riboflavin levels measured by methemoglobin reduction by cystamine in ...
Cystamine relaxed and reduced [Ca(2+) ]i in phenylephrine-contracted arteries. In potassium-contracted arteries, cystamine ... Cystamine and the Rho kinase inhibitor Y27632 reduced basal MYPT1-Thr(855) phosphorylation, but only Y27632 reduced ... Cystamine concentration-dependently inhibited curves for phenylephrine, 5-hydroxytryptamine, U46619, and for extracellular K ... Blockers of voltage-gated potassium KV 7 channels, XE991 and linopirdine inhibited cystamine relaxation and increases in ...
RGD Targeted Poly(L-Glutamic Acid)-Cystamine-(Gd-DOTA) Conjugate for Detecting an Angiogenesis Biomarker &[alpha]v&[beta]3 ... RGD targeted poly(glutamic acid)-cystamine-(Gd-DOTA) conjugate was prepared for detecting the angiogenesis biomarker ?v?3 ...
Three salts from the reactions of cyste-amine and cystamine with L-(+)-tartaric acid. ...
"Inhibition of melanin synthesis by cystamine in human melanoma cells". The Journal of Investigative Dermatology. 114 (1): 21-27 ...
Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid Nanda SS, An SS, Yi DK ...
Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid Nanda SS, An SS, Yi DK ...
  • The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. (patents.com)
  • Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. (nih.gov)
  • Interrelationships between cysteine, methionine, cysteamine and cystamine. (google.it)
  • Cystamine is an unstable liquid and is generally handled as the dihydrochloride salt, C4H12N2S2·2HCl, which is stable to 203-214 °C at which point it decomposes. (wikipedia.org)
  • Cystamine dihydrochloride is a useful reagent to derivatize various polymer monoliths for hydrophilic interaction liquid chromatography, as a crosslinking agent in the development of polymer hydrogels, and as a functional group in nanoparticles developed for siRNA and DNA delivery. (wikipedia.org)
  • Pretreatment of rats with cystamine dihydrochloride (300 mg/kg, p.o.) 30 min prior to CCl 4 (0.25 ml/kg, i.p.) prevented CCl 4 -induced hepatic necrosis, plasma enzyme elevations, and hepatic calcium accumulation. (elsevier.com)
  • Cystamine (2,2'-dithiobisethanamine) is an organic disulfide. (wikipedia.org)
  • Cystamine is an organic disulfide which is formed when Cystine is heated as a result of decarboxylation. (wikipedia.org)
  • Cystamine in the body is reduced into cysteamine and RS-cysteamine mixed disulfide by thiol-disulfide exchange. (wikipedia.org)
  • The disulfide chain allows the mono-BOC-cystamine to be easily cleaved, allowing removal of the tagging residue when desired. (wikipedia.org)
  • Cysteamine, an endogenous aminothiol, and cystamine, the disulfide product of oxidation, increase Pseudomonas aeruginosa sensitivity to reactive oxygen and nitrogen species and potentiate therapeutic antibiotics against bacterial infection. (novabiotics.co.uk)
  • The effect of a cystamine derivative, bis(2-(E-2-hexenoylamino)ethyl) disulfide, on rat platelet aggregation. (nii.ac.jp)
  • Cystamine is an organic disulfide: the molecule features two bound sulfur atoms to each of which an ethylamine group is attached. (phys.org)
  • The affinity of cystamine to DNA plays a role in the toxicity and radioprotecting properties of cystamine. (wikipedia.org)
  • The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. (lu.se)
  • The present report deals with a series of experiments on the effects of cystamine, cysteamine and cysteine when added to cultures of chick fibroblasts shortly before irradiation. (nature.com)
  • Cystamine has also been studied as a potential medicinal compound in the case of Huntington's disease, Alzheimer's disease and carbon tetrachloride liver damage Cystamine has been shown to interact with DNA and reversibly bind to it. (wikipedia.org)
  • 2. A method of treating a subject with cystinosis comprising administering a composition of claim 1 less than 4 times per day, wherein the total daily dose of cystamine is about 1.35 g/m.sup.2 body surface area or less. (patents.com)
  • When administered up to 12 h after CCl 4 , a single oral dose of cystamine inhibited necrosis in a dose-dependent manner, but did not reduce CCl 4 -induced plasma enzyme elevation or hepatic calcium accumulation. (elsevier.com)
  • At high concentrations cystamine induces an abnormal tubulin polymerization. (wikipedia.org)
  • Here, we report a new pathway in which cystamine induces apoptosis by targeting apoptosis-inducing factor (AIF). (elsevier.com)
  • CONCLUSIONS AND IMPLICATIONS: Our findings suggest that cystamine induces vasodilatation by inhibition of receptor-coupled TG2 leading to opening of KV channels and reduction of intracellular calcium, and by activation of a pathway sensitive to inhibitors of the mitochondrial complexes I and III. (au.dk)
  • Acute toxicity and radioprotective effects of amifostine (WR-2721) or cystamine in single whole body fission neutrons irradiated rats" (PDF). (wikipedia.org)
  • Treatment of O rats with cystamine (tTG inhibitor) lead to a decrease in vascular stiffness as measured by pulse wave velocity (5.55 ± 0.11 m/s to 4.99 ± 0.22 m/s, n = 6, p = 0.038). (ahajournals.org)
  • Multiple factors of potential cystamine toxicity have been described relating to hepatoxicity, anti-coagulant activity and skin sensitisation. (wikipedia.org)
  • These results indicate that AIF translocation through glutathione depletion is the molecular mechanism of cystamine toxicity, and provide important implications for cystamine in the neurodegenerative disease therapeutics as well as in the regulation of AIF-mediated cell death. (elsevier.com)
  • The interaction of cystamine interferes with the formation of microtubules, thus acting as an anti-microtubule at low concentrations. (wikipedia.org)
  • Instead, cystamine interferes with the orderly assembly of HIV virions, as shown by electron microscopy analysis, that reveals only defective viral particles in treated cells. (jci.org)
  • Mono-BOC-cystamine (mono BOC protected cystamine ) is a tert-butyloxycarbonyl (BOC) derivative of cystamine used as crosslinker in biotechnology and molecular biology applications. (wikipedia.org)
  • 8. A composition comprising:an enterically coated cystamine or cystamine derivative. (patentsencyclopedia.com)
  • A series of polyacrylamide-octadecyl methacrylate hydrogels crosslinked by N,N′-bis (acryloyl) cystamine were synthesized as potential chemical sensitive system. (hindawi.com)
  • Moreover, suppression of HIV replication, due to the inhibition of proviral DNA formation was observed in acutely infected lymphocytes and macrophages pretreated with cystamine. (jci.org)
  • Contributors discuss the biochemical and clinical aspects of hemoglobin abnormalities and cover topics ranging from amino acid substitutions to sickle cell disease, glycosylated hemoglobins, cystamine inhibition of sickling, and gelation of sickle cell hemoglobin. (elsevier.com)
  • The present study hypothesized that inhibition of TG2 followed by blockade of smooth muscle calcium entry and/or inhibition of Rho kinase underlie cystamine vasodilatation. (au.dk)
  • Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells. (jci.org)
  • These results show that cystamine potently suppresses HIV replication in human cells by contemporaneously blocking at least two independent steps of the viral life cycle, without affecting cell viability, suggesting that this compound may represent a new possibility towards the treatment of HIV-1 infection. (jci.org)
  • In cystamine-sensitive cells, cystamine suppresses the levels of intracellular glutathione by inhibiting γ-glutamylcysteine synthetase expression that triggers AIF translocation. (elsevier.com)
  • BACKGROUND AND PURPOSE: Vasodilatation may contribute to the neuroprotective and vascular antiremodelling effect of the tissue transglutaminase (TG2) inhibitor cystamine. (au.dk)
  • Both pathways may contribute to the antihypertensive and neuroprotective effect of cystamine. (au.dk)
  • Mono-BOC-cystamine is used as a crosslinker for the synthesis of a biodegradable cystamine spacer in PGA-cystamine-Gd-DO3A, which shows improved MRI contrast for breast carcinoma imaging in mice. (wikipedia.org)
  • Mice with oculopharyngeal muscular dystrophy, caused by aggregation of a nuclear protein, show improvement when treated with cystamine, suggesting a possible therapeutic approach for patients. (sciencemag.org)
  • Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. (sigmaaldrich.com)
  • Treatment of NOS-3 mice with cystamine decreased aortic stiffness and increased carotid artery compliance. (ahajournals.org)
  • Cystamine improves functional recovery via axon remodeling and neuroprotection after stroke in mice," CNS Neuroscience & Therapeutics , vol. 21, no. 3, pp. 231-240, 2015. (hindawi.com)
  • Furthermore, cystamine can cause liver damage by elevating cytosolic Ca2+ levels and subsequently activating a cytosolic proteolytic system. (wikipedia.org)
  • HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection. (nih.gov)
  • Effect of cystamine on liver lipids. (bvsalud.org)
  • Five cystamine molecules can bind covalently to tubulin, this will cause mediated aggregation of tubulins. (wikipedia.org)
  • The immobilization principle is based on the high affinity of sulfur atoms (present in Cystamine) on gold and the reactions between free amine molecules from proteins (or peptides) and aldehyde molecules (present in Glutaraldehyde). (horiba.com)
  • They were able to first synthesize cage-like molecules with 3 cystamine ligands closing off 'holes' in the molecules. (phys.org)
  • Conversely, glutathione supplementation completely prevents cystamine-induced AIF translocation and apoptosis. (elsevier.com)
  • We tested whether cystamine could have such properties in a Parkinson's disease murine model and now provide evidence that it can not only prevent the neurodegenerative process but also can reverse motor impairments created by a 6-hydroxydopamine lesion 3weeks post-surgery. (lu.se)
  • Cystamine and its reduced form cysteamine showed protective effects in various models of neurodegenerative disease, including Huntington's disease and Parkinson's disease. (elsevier.com)
  • An inhibitor of phospholipase C suppressed cystamine relaxation. (au.dk)
  • Cystamine and the Rho kinase inhibitor Y27632 reduced basal MYPT1-Thr(855) phosphorylation, but only Y27632 reduced phenylephrine-induced increases in MYPT1-Thr(855) and MLC2 phosphorylation. (au.dk)
  • Thiols can be synthesized to disulfides like cystamine through chemical oxidation with various oxidizing agents (molecular oxygen, metal ion, metal oxide, DMSO, nitric oxide, halogen and sodium perborate), through electrochemical oxidation and through borohydride exchange resin (BER)-transition metal salts systems (like BER-CuSo4). (wikipedia.org)
  • Cystamine post-treatment, therefore, does not appear to inhibit toxicant-induced influx of extracellular calcium into toxicant-damaged cells. (elsevier.com)
  • Palanski BA, Khosla C. Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism. (harvard.edu)
  • Importantly, we report that cystamine has neurorestorative properties 5weeks post-lesion as seen on the number of nigral dopaminergic neurons which is comparable with treatments of cysteamine, the reduced form of cystamine used in the clinic, as well as rasagiline, increasingly prescribed in early parkinsonism. (lu.se)
  • Cysteamine, the reduced form of cystamine, is an FDA-approved drug. (sigmaaldrich.com)
  • Cystamine has also been shown to interact with the production of microtubule assemblies in bovine brain tissue. (wikipedia.org)
  • Evidence for a slightly earlier regeneration of hepatic tissue was noted when cystamine was administered 12 h after CCl 4 . (elsevier.com)
  • We have investigated the effects of cystamine on the replication of human immunodeficiency virus (HIV) in human lymphocytes and macrophages, the natural targets of HIV in vivo. (jci.org)
  • The disease-modifying effects displayed by cystamine/cysteamine would encourage clinical testing. (lu.se)
  • Mono-BOC-cystamine is used as a crosslinker for the synthesis of cleavable photo-cross-linking reagent. (wikipedia.org)
  • Skin sensitisation is a predicted effect of cystamine being a thiol. (wikipedia.org)
  • Amelioration of CCl 4 -induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine pretreatment and possible mechanisms of the post-toxicant cytoprotective effect were investigated. (elsevier.com)
  • The mild hypothermia induced by post-toxicant treatment with cystamine did not delay the apperance of the lesion. (elsevier.com)
  • rather, it is associated with the ability of cystamine to trigger AIF nuclear translocation. (elsevier.com)
  • Biological context of Setdb 1 The combined pharmacological treatment with mithramycin and cystamine down. (wikigenes.org)
  • A quantitative animal model was developed to study amelioration of carbon tetrachloride-induced hepatic injury by post-toxicant administration of cystamine. (elsevier.com)
  • This led us to discover KC7F2, a lead compound with a central structure of cystamine. (aacrjournals.org)
  • Experimental and computational studies of the cage structure showed that the cystamine ligands close off areas that would otherwise be apertures. (phys.org)
  • The structure synthesized by the researchers is a metallomolecular cage, involving three cobalt ions linked by three cystamine ligands. (phys.org)
  • A radiation-protective agent that oxidizes in air to form CYSTAMINE. (medconditions.net)
  • By screening of various cell lines, we observed that cystamine and cysteamine induce cell death in a cell type-specific manner. (elsevier.com)
  • Indeed, cystamine is in phase II studies in humans with HD. (jneurosci.org)