Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Cystadenoma, Serous: A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)Cystadenoma, Papillary: A benign neoplasm of the ovary.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Mucocele: A retention cyst of the salivary gland, lacrimal sac, paranasal sinuses, appendix, or gallbladder. (Stedman, 26th ed)Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Appendix: A worm-like blind tube extension from the CECUM.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Sertoli-Leydig Cell Tumor: A sex cord-gonadal stromal tumor consists of LEYDIG CELLS; SERTOLI CELLS; and FIBROBLASTS in varying proportions and degree of differentiation. Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS.Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Adenolymphoma: A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Cecal Diseases: Pathological developments in the CECUM.Hepatic Duct, Common: Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.Spermatocele: A cystic dilation of the EPIDIDYMIS, usually in the head portion (caput epididymis). The cyst fluid contains dead SPERMATOZOA and can be easily differentiated from TESTICULAR HYDROCELE and other testicular lesions.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Aspermia: A condition characterized by the complete absence of SEMEN. This disorder should be differentiated from AZOOSPERMIA, absence of sperm in the semen.Pseudomyxoma Peritonei: A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Pancreatic Cyst: A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)Urologic Surgical Procedures, Male: Surgery performed on the male genitalia.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Retroperitoneal NeoplasmsSalivary Glands, Minor: Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Pancreatic Pseudocyst: Cyst-like space not lined by EPITHELIUM and contained within the PANCREAS. Pancreatic pseudocysts account for most of the cystic collections in the pancreas and are often associated with chronic PANCREATITIS.Ovarian Cysts: General term for CYSTS and cystic diseases of the OVARY.Cholangiopancreatography, Magnetic Resonance: Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.Pancreatic Diseases: Pathological processes of the PANCREAS.Bile Ducts, Extrahepatic: Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).Appendectomy: Surgical removal of the vermiform appendix. (Dorland, 28th ed)Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Lacrimal Apparatus Diseases: Diseases of the lacrimal apparatus.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.von Hippel-Lindau Disease: An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.MassachusettsVon Hippel-Lindau Tumor Suppressor Protein: A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.Hemangioblastoma: A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)Hospitals, General: Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients.BostonRetinal Neoplasms: Tumors or cancer of the RETINA.
Third International Meeting on von Hippel-Lindau disease. (1/27)Five years after the identification of the von Hippel-Lindau (VHL) gene, physicians, scientists and concerned VHL family members met to review the current state of knowledge on the diagnosis and treatment of VHL and to summarize the latest information on the biochemistry of the VHL protein (pVHL). The NIH and University of Pennsylvania groups reported the detection of germ-line mutations in 100% (93 of 93) of VHL families studied. Several studies determined the frequency of VHL germ-line mutations in individuals with a single manifestation of VHL without a family history of VHL. National groups to improve the diagnosis and treatment of individuals with VHL disease have been established in Great Britain, Denmark, France, Holland, Italy, Japan, Poland, and the United States. Evidence for the existence of genes that modify the expression of VHL was presented. The VHL protein appears to have several distinct functions: (a) down-regulation of hypoxia-inducible mRNAs; (b) proper assembly of the extracellular fibronectin matrix; (c) regulation of exit from the cell cycle; and (d) regulation of expression of carbonic anhydrases 9 and 12. (+info)
CDKN2A gene inactivation in epithelial sporadic ovarian cancer. (2/27)The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous deletion, mutation and methylation status of the CDKN2A gene as well as CDKN2A expression were examined in a panel of serous papillary ovarian cancer. The frequency of loss of heterozygosity (LOH) for one or more informative markers at 9p21-22 was 65% (15/23). The most common deleted region was located between interferon (IFN)-alpha and D9S171. Homozygous deletions and mutations of the CDKN2A gene were not found. There was no evidence of methylation in exon 1, but methylation in exon 2 of CDKN2A gene was found in 26% (6/23). Absence of CDKN2A gene expression was shown in 27% (6/22) at mRNA level and 21% (4/19) at protein level. These data suggest that the CDKN2A gene is involved in the tumorigenesis of ovarian cancer, but the mechanisms of CDKN2A gene inactivation in serous papillary ovarian cancer remains unclear. (+info)
Ovarian micropapillary serous borderline tumors. Clinicopathologic features and outcome of seven surgically staged patients. (3/27)We report the clinicopathologic findings for 7 patients with completely staged ovarian micropapillary serous borderline tumors (MSBTs) to further clarify tumor behavior. None of the MSBTs had microinvasion in the ovarian neoplasm. The MSBT pattern constituted 25% to almost all of the neoplasm. Four were bilateral, and 6 involved the ovarian surface. Five patients had peritoneal implants; 2 were invasive, and 3 were noninvasive MSBTs. Distribution of stages among patients was as follows: IA, 1; IC, 1; IIC, 2; IIIB, 2; and IIIC, 1. Median follow-up was 8.5 years. Four patients were alive and well at the last follow-up visit, including 1 patient with stage IIIC (lymph node metastases) disease who had noninvasive implants (12 years after surgery). One patient who was free of disease died of complications of chemotherapy and abdominal surgery. Two patients died of intra-abdominal neoplastic growth (stages IIC and IIIB) 5 and 9 years after surgery, respectively; both had invasive implants. Without invasive peritoneal implants, MSBTs seem to behave as similar staged nonmicropapillary serous borderline tumors without invasive peritoneal implants. With invasive peritoneal implants, they seem to behave as low-grade carcinomas. Pathologists should recognize MSBT as a neoplasm that can have adverse prognostic features, including invasive peritoneal implants. (+info)
Expression of laminin-5-gamma-2 chain in intraductal papillary-mucinous and invasive ductal tumors of the pancreas. (4/27)The laminin-5-gamma-2 chain is expressed in various invasive carcinoma cells. To clarify the relationship between laminin-5 expression and the development of intraductal papillary-mucinous tumors (IPMTs), we performed an immunohistochemical study of 26 IPMTs and 30 invasive ductal adenocarcinomas. Cases were classified into five groups: intraductal papillary-mucinous adenoma (Group A; n = 8), adenocarcinoma without invasion (Group B; n = 3), adenocarcinoma with minimal invasion (Group C; n = 5), adenocarcinoma with macroscopically evident invasion (Group D; n = 10), and invasive ductal adenocarcinoma (conventional type; Group E; n = 30). In the invasive components of Groups D and E, laminin-5 was expressed in 80% and 100% of cases, respectively. In the intraductal components of IPMTs, expression of laminin-5 was not seen in Groups A and B, whereas they were seen in one case in Group C (20%) and in seven in Group D (70%). Most of the staining patterns of the intraductal components were focal and scattered. Laminin-5-gamma-2 expression in the intraductal components of IPMTs tends to increase as tumors develop and may be a indicator of the potential invasiveness of the tumor cells. (+info)
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. (5/27)Solid-pseudopapillary tumors (SPTs) are unusual pancreatic neoplasms of low malignant potential that most frequently affect young women. Genetic events contributing to the development of SPTs are unknown. Whereas the more common ductal adenocarcinomas of the pancreas essentially never harbor beta-catenin or APC gene mutations, we have recently identified alterations of the APC/beta-catenin pathway in other nonductal pancreatic neoplasms including pancreatoblastomas and acinar cell carcinomas. We analyzed a series of 20 SPTs for somatic alterations of the APC/beta-catenin pathway using immunohistochemistry for beta-catenin protein accumulation, direct DNA sequencing of beta-catenin exon 3, and direct DNA sequencing of the mutation cluster region in exon 15 of the APC gene in those SPTs that did not harbor beta-catenin mutations. Immunohistochemical labeling for cyclin D1 was performed to evaluate the overexpression of this cell-cycle protein as one of the putative downstream effectors of beta-catenin dysregulation. In addition, we analyzed the SPTs for genetic alterations commonly found in pancreatic ductal adenocarcinomas, including mutations in the K-ras oncogene and p53 and DPC4 tumor suppressor genes, using direct DNA sequencing of K-ras and immunostaining for p53 and Dpc4. Almost all SPTs harbored alterations in the APC/beta-catenin pathway. Nuclear accumulation of beta-catenin protein was present in 95% (19 of 20), and activating beta-catenin oncogene mutations were identified in 90% (18 of 20) of the SPTs. Seventy-four percent (14 of 19) showed overexpression of cyclin D1, ranging from 10 to 70% of tumor nuclei. In contrast, no K-ras mutations were present in any of the 20 SPTs, and Dpc4 expression was intact in all 16 SPTs for which immunohistochemical labeling was successful. Overexpression of p53 was limited to only 3 of 19 (15.8%) SPTs. These results emphasize the two distinct, divergent genetic pathways of neoplastic progression in pancreatic ductal and nonductal neoplasms. (+info)
Solid--cystic papillary tumor of pancreas. (6/27)A case of Solid and Cystic Papillary Epithelial Tumor of Pancreas displaying low grade malignancy occurring in a 38 years old female is presented. It is a rare condition and could be diagnosed histopathologically after complete excision. (+info)
Differential diagnosis of benign and malignant intraductal papillary mucinous tumors of the pancreas: MR cholangiopancreatography and MR angiography. (7/27)OBJECTIVE: To compare the usefulness of magnetic resonance cholangiopancreatography (MRCP) and MR angiography (MRA) in differentiating malignant from benign intraductal papillary mucinous tumors of the pancreas (IPMTs), and to determine the findings which suggest malignancy. MATERIALS AND METHODS: During a 6-year period, 46 patients with IPMT underwent MRCP. Morphologically, tumor type was classified as main duct, branch duct, or combined. The diameter of the main pancreatic duct (MPD), the extent of the dilated MPD, and the location and size of the cystic lesion, septum, and communicating channel were assessed. For all types of IPMTs, enhanced mural nodules and portal vein narrowing were evaluated at MRA. RESULTS: Combined-type IPMTs were more frequently malignant (78%) than benign (42%) (p < 0.05). Compared with benign lesions, malignant lesions were larger, and the caliber of the communicating channel was also larger (p < 0.05). Their dilated MPD was more extensive and of greater diameter (p < 0.05), and the presence of mural nodules was more frequent (p < 0.001). CONCLUSION: Combined MRCP and MRA might be useful for the differential diagnosis of malignant and benign IPMTs of the pancreas. (+info)
Papillary cystadenoma arising from the upper lip: a case report. (8/27)We report a rare case of a papillary cystadenoma arising from the upper lip. This tumor was not distinctly encapsulated and had proliferated replacing the ductal epithelium. Mast cells were found not only in the stroma but also in the oncocytic epithelial layer. There was a strong immunoreaction with mitochondrial antibody in the epithelial layer. Only one case (0.9%) of papillary cystadenoma has occurred among the 110 benign intraoral salivary gland tumors seen in our hospital from 1966 through September 2003. (+info)
Week 402: Case 6 | Johns Hopkins Surgical Pathology Unknown Conference
Answer: Papillary cystadenoma. Histology: The tumor consists of lobules composed of papillary structures lined by cells with abundant to clear cytoplasm. Nuclei appear uniform and small without atypia or mitotic figures. In areas, the tumor is seen projecting within small cystic structures.. Discussion: Approximately 50% of cases of papillary cystadenoma of the epididymis are associated with von Hippel-Lindau disease. Especially in the setting of von Hippel-Lindau disease, the differential diagnosis is between papillary cystadenoma and metastatic renal cell carcinoma as patients with von Hippel-Lindau disease are at increased risk of having renal cell carcinoma. Some cases of papillary cystadenoma are composed of small solid nests of cells separated by a fine, thin vasculature where they can closely resemble renal cell carcinoma. Other areas will show a more papillary configuration with the same clear cytoplasm that is more typical of papillary cystadenoma and would be unusual in clear cell ...
Ovarian Solid Pseudopapillary Tumor Resembling Benign Hemorrhagic Cyst on Rapid Frozen Section
Solid pseudopapillary tumors are rare, with the majority of described cases originating in the pancreas. To date, there are only 10 documented reports of primary ovarian solid pseudopapillary tumors. Here, we describe the case of a 24-year-old woman who presented with worsening pelvic pain and dysmenorrhea. Workup demonstrated a right ovarian solid mass on ultrasound and an elevated serum LDH, which raised concerns for dysgerminoma due to her relatively young age. Therefore, she was taken to the operating room and underwent laparoscopic right salpingo-oophorectomy. On initial rapid frozen section, her ovarian cyst had a grossly hemorrhagic appearance with multiple hemosiderin deposits noted microscopically, which suggested a benign hemorrhagic cyst. However, the final pathology was reported as solid pseudopapillary tumor based on several defining histologic characteristics. Most importantly, immunostaining was positive for |i|β|/i|-catenin and negative for E-cadherin. This report presents a brief
Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas<...
TY - JOUR. T1 - Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. AU - Tang, Wendell W.. AU - Stelter, Arwen A.. AU - French, Samuel. AU - Shen, Steven. AU - Qiu, Suimin. AU - Venegas, Rose. AU - Wen, Julie. AU - Wang, Hui Qun. AU - Xie, Jingwu. PY - 2007/5/30. Y1 - 2007/5/30. N2 - Solid pseudopapillary tumor of pancreas (SPT) is a rare neoplasm that occurs most often in young females with the two distinct features, the solid-cystic gross appearance, and the solid-pseudopapillary microscopic pattern. It has been reported that almost all SPT tumors contain a mutation in the β-catenin gene; however, the histogenetic origin of this tumor remains largely a mystery. E-cadherin is a cell adhesion molecule that links to catenins to form cell adhesion junctions, which is associated with the cytoskeleton formation. In this study, we examined the expression of E-cadherin and β-catenin from SPT in an attempt to determine the molecular basis for the unusual ...
PAPILLARY CYSTADENOMA OF LACRIMAL CARUNCLE | British Journal of Ophthalmology
Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases Ovarian Cancer and Us ...
Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low-grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that ,1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area. The pathological features of the two tumors, including solid and pseudopapillary growth patterns with pale or eosinophilic cytoplasm, were characteristic of SPTs of the pancreas. However, in the case of the metastatic ovarian tumor, focal necrosis and an increased nuclear-to-cytoplasmic ratio were observed. The presence of positive nuclear-cytoplasmic β-catenin, ...
Pancreas: Solid pseudopapillary tumour of the pancreas with t(11;22)(q24;q12) EWSR1/FLI1
Multidetector CT of multicentric solid pseudopapillary tumor of the pancreas: a case report and review of the literature.
Cystic Tumors of the Pancreas - Nova Science Publishers
Cystic tumors of the pancreas today are diagnosed more frequently in clinical practice, mainly due to an increased use of the modern advanced imaging modalities.. Bland cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. However, the current knowledge concerning the development of cystic neoplasias of the pancreas is still rudimentary.. Histopathologically, 90% of pancreatic cystic neoplasias are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary mucinous (IPMN) and solid pseudopapillary (SPN) neoplasias. Surgical treatment of these lesions can be highly challenging and occasionally demands complex surgical approaches that should be put in the hands of skilled pancreatic surgeons in experienced high-volume centers.. While some of the described cystic tumors are harmless, such as SCNs of the pancreas, others such as IPMN and MCN harbor relevant malignant potential. The differential diagnosis of these lesions ...
Risk of Malignancy in Unilocular Ovarian Cystic Tumors Less Than 10 Centimeters in Diameter - PDF
Tumors of the Pancreas - Dana-Farber/Boston Children's Cancer and Blood Disorders Center
The pediatric Solid Tumor Center at Dana-Farber/Boston Children's treats children and teens with a variety of solid malignancies, including tumors of the pancreas.;Tumors of the pancreas can develop from the organs exocrine cells, which make enzymes to aid in digestion, or endocrine cells, which produce hormones such as insulin and glucagon that control blood sugar levels. ;Several different types of pancreatic tumors can develop in children, such as solid pseudopapillary tumors (SPTs), pancreatoblastomas, and neuroendocrine tumors (NETs).
Pancreatic schwannoma: a case report and an updated 40-year review of the literature yielding 68 cases | BMC Cancer | Full Text
Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and present a review of the cases currently reported in the English literature to identify characteristics of pancreatic schwannoma on imaging. A 53-year-old male presented with a history of intermittent periumbilical abdominal pain and lower back pain for 1 week. Based on ultrasound (US) and computed tomography (CT) findings, we made a preoperative diagnosis of solid pseudopapillary tumor and performed a standard pancreaticoduodenectomy. Pathological examination showed that the tumor was composed of spindle cells with a palisading arrangement, and immunohistochemistry revealed strong positive staining for S-100 protein, which was consistent with a diagnosis of pancreatic schwannoma. At the 8-month follow-up visit, the patient was doing well without recurrent disease, and his abdominal pain had
CiNii 論文 - Pancreatobiliary Fistula Associated with an Intraductal Papillary-Mucinous...
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2...
TY - JOUR. T1 - High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters. AU - Sugio, Kenji. AU - Gazdar, Adi F.. AU - Albores-Saavedra, Jorge. AU - Kokkinakis, Demetrius M.. PY - 1996. Y1 - 1996. N2 - Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in ~90% of cases. In contrast, K-ras mutations are found in ,50% of the relatively rare intraductal papillary mucinous tumor (IPMT), which arises in the main pancreatic ducts. Since both adenocarcinomas and IPMTs are believed to arise from ductal cells and progress through similar sequences of morphological changes (i.e. flat hyperplasia, papillary hyperplasia, atypia and carcinoma in situ), it is clear that such progression may not always necessitate activation of the ras oncogene. Experimentally ductal adenocarcinomas of the ...
Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: Clinicopathologic and...
TY - JOUR. T1 - Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas. T2 - Clinicopathologic and immunohistochemical study of eight cases. AU - Fukushima, Noriyoshi. AU - Mukai, Kiyoshi. AU - Sakamoto, Michiie. AU - Hasebe, Takahiro. AU - Shimada, Kazuaki. AU - Kosuge, Tomoo. AU - Kinoshita, Taira. AU - Hirohashi, Setsuo. PY - 2001/7/30. Y1 - 2001/7/30. N2 - Most intraductal papillary-mucinous carcinomas (IPMCs) of the pancreas are resectable and curable, but some develop into frankly invasive carcinomas. We studied the clinicopathologic features of eight cases of invasive carcinoma derived from IPMC (IC-IPMC) of the pancreas. The patients were aged 54-75 years (mean, 66.6 years); six were male and two were female. The mean tumor size was 7.7 cm (range 5.5-10.5 cm). Two patients without lymph node metastasis had no peripancreatic invasion, and survived longer (115 and 20 months). Three out of four patients with extrapancreatic invasion died of their tumors or ...
Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas<...
TY - JOUR. T1 - Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas. AU - Raimondo, Massimo. AU - Tachibana, Issei. AU - Urrutia, Raul. AU - Burgart, Lawrence J.. AU - DiMagno, Eugene P.. PY - 2002/10/1. Y1 - 2002/10/1. N2 - OBJECTIVES: Intraductal papillary mucinous tumor (IPMT) is frequently associated with pancreatic cancer. We hypothesized that IPMT progresses to invasive cancer with K-ras mutations as an early event, and that invasive cancer affects survival. We compared survival after resection and determined whether K-ras mutations predicted survival in IPMT patients without or with invasive cancer. METHODS: Records of 47 patients with IPMT who were seen between 1983 and 1998 were reviewed retrospectively in 15 cases and prospectively in 32. All histological material was reviewed to confirm the diagnosis of IPMT and to assess invasion. Kaplan-Meier survival curves were analyzed by the log-rank test. The X2 test was used for differences in K-ras between ...
MRI appearance of ovarian serous borderline tumors of the micropapillary type compared to that of typical ovarian serous...
SPEN(Solid and papillary epithelial neoplasm of pancreas), IPMT(Intraductal papillary mucinous tumor) = mucinous ductal ectasia...
SPEN(Solid and papillary epithelial neoplasm of pancreas) 10-20대 여성(흑인)에서 주로 발생, low malignant potential * CT : large cystic tumor of pancreas * Gross : solitary, large(8-10cm), pseudocapsule cross-section: solid & cystic component 내부에 hemorrhage & necrosis동반 * Micro : uniform eosinophilic granular cytoplasm round to oval nuclei with indistinct nucleoli mitotic rate↓ IPMT(Intraductal papillary mucinous tumor) = mucinous ductal ectasia pancreas head에 주로 생기고 남자에 많다. pancreatitis를 잘 일으키며 ERCP상 duct dilatation내에 filling defect(mucin)으로 나타난다. ERCP에서 ampulla of Vater로 mucin이 흘러내리는 것을 관찰할수 있다. premalignant lesion으로 수술적 절제가 필요하다. mucin fluid에 CA 19-9가 증가해 있다. Cystic neoplasm serous & mucinous cystic neoplasm의 두 종류가 있으며 serous neoplasm은 benign, mucinous neoplasm은 premalignant lesion이다. 둘다 중년 여성에 많고, ...
Intra and extra-hepatic cystadenoma of the biliary duct. Review of literature and radiological and pathological characteristics...
Histologically, cystoadenomas are characterised by the presence of cysts lined with mucinous cuboidal or columnar epithelium.6 An ovarian-type stroma is seen in 85% of cases and exclusively in females.4 A marsupial pseudocapsule separates the cystadenoma from the biliary epithelium.4 Elevated levels of CA 19-9 and/or CEA have been reported within the cysts themselves.1 2 4 11 12. Although the biliary cystadenoma is a benign entity, malignant transformation can occur, leading to cystadenocarcinoma.4 Sarcomatous transformation has also been described in one case.6 It has been suggested that cystadenocarcinomas arising from biliary cystadenomas with ovarian-type stroma have a relatively indolent course, whereas cystadenomas without ovarian-type stroma have a poorer prognosis.4. Most commonly, on radiologic imaging, these neoplasms appear as multi-loculated, multi-septated intrabiliary neoplasms. They are usually large at the time of presentation, with a mean tumour size of 15 centimetres.4 On CT, ...
What Is Mucinous Cystadenoma? (with pictures)
Hepatic Cystadenoma: An Unusual Presentation
A 53-yr-old woman with a history of hepatic cystadenoma 25 yr before presented with a simple hepatic cyst, which evolved over 9 yr into a complex cystadenoma with septations and internal bleeding. She was treated with a left hepatectomy. Review of the literature shows that hepatic cystadenomas, although rare, frequently can recur years later and have potential for malignant transformation. Histologic similarities of one variant with ovarian stroma raises interesting possibilities regarding the origin of these lesions. The best treatment results are obtained with radical excision ...
Causes of ovarian serous cystadenoma - Things You Didn't Know
Causes of ovarian serous cystadenoma - What causes an ovarian serous cystadenoma to rupture do I need surgery if rupture? Pressure. The increased pressure and weak wall of the ovary can cause it to rupture - you do not need surgery if it does. You might consider getting it removed before it does though.
E-cadherin can limit the transforming properties of activating β-catenin mutations - UEA Digital Repository
Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating mutations in β-catenin (CTNNB1). We have compared the dynamics and the potency of β-catenin mutations in vivo. Within the murine small intestine (SI), an activating mutation of β-catenin took much longer to achieve a Wnt deregulation and acquire a crypt-progenitor-cell (CPC) phenotype than Apc or Gsk3 loss. Within the colon, a single activating mutation of β-catenin was unable to drive Wnt deregulation or induce the CPC phenotype. This ability of β-catenin mutation to differentially transform the SI versus the colon correlated with significantly higher expression of the β-catenin binding partner E-cadherin. This increased expression is associated with a higher number of E-cadherin:β-catenin complexes at the membrane. Reduction of E-cadherin ...
E‐cadherin can limit the transforming properties of activating β‐catenin mutations | The EMBO Journal
When we examined solid pseudopapillary tumours of the pancreas, a tumour characterised by β‐catenin mutations within exon 3, these tumours showed a strong reduction in E‐cadherin:β‐catenin complexes. Moreover in HCC, a tumour type which has approximately 20% β‐catenin exon 3 mutations, there was a good correlation between reduction in E‐cadherin and activation of Wnt signalling targets. Thus, it may be that in these cancers, E‐cadherin limits the precise levels of Wnt signalling driven by β‐catenin mutation. Thus, downregulation of E‐cadherin in these tumours may drive tumour progression. It should also be noted that opposing patterns of Wnt signalling and E‐cadherin have been shown in murine liver, with β‐catenin higher in zone 3 of the liver and E‐cadherin in zone 1. Therefore, one might predict that β‐catenin mutations would yield a greater phenotype in hepatocytes from zone 3 of the liver versus zone 1 (Benhamouche et al, 2006). Hence, one could speculate ...
"Review of paratesticular pathology: findings on ultrasound and MRI" by Refky Nicola, Christine O. Menias et al.
The paratesticular scrotal contents consist of the spermatic cord, epididymis, and fascia, which originate from the embryologic descent of the testis through the abdominal wall. Historically, the primary diagnostic modality has been high-resolution ultrasound. Magnetic resonance imaging (MRI) is an alternative imaging option. Both contrast MRI and diffusion weighted imaging can assist in differentiating between benign and malignant lesions. Unlike the testis which most disease processes are malignant, a wide spectrum of benign disease processes affects the paratesticular region either in isolation or as part of a contiguous disease process from adjacent organs. The familiarity with the epidemiology, pathogenesis, and imaging features can aid the radiologic diagnoses and guide appropriate clinical management. In this article, we review the ultrasound and MR characteristics of various paratesticular pathologies.
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Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "Radiology, Pediatric Radiology"
BIO-SYNTHESIS - Custom Antibody Custom Peptide Synthesis Custom SiRNA Synthesis: Unc93a Antibody
Unc93a, a human homolog of the C. elegans Unc93 gene, was initially identified by the sequencing of chromosome 6q27 at D6S193 as loss at this region correlated with sporadic ovarian cancer. Further analysis however, showed no tumor suppressor role for Unc93a. Unlike Unc93b, another homolog of the C. elegans Unc93 gene that is crucial for Toll-like receptor (TLR) signaling, the function of Unc93a is unknown. It is expressed in testis, small intestine, spleen, prostate and ovary. Two isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93b. ...
POPLINE Keyword Guide -- Main Index
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Download Surgery for Ovarian Cancer: Principles and Practice, Second by Robert E. Bristow, Beth Y. Karlan, Dennis S. Chi PDF -...
Ann Oncol 2010; 21(1):55-60. 156. Burks RT, Sherman ME, Kurman RJ. Micropapillary serous carcinoma of the ovary. A distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 1996; 20:1319-1330. 157. Seidman JD, Kurman RJ. Subclassification of serous borderline tumors of the ovary into benign and malignant types. A clinicopathologic study of 65 advanced stage cases. Am J Surg Pathol 1996; 20:1331-1345. 158. Eichhorn JH, Bell DA, Young RH, et al. Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. 234. Scully RE. Gonadoblastoma: a gonadal tumor related to dysgerminoma (seminoma) and capable of sex hormone production. Cancer 1953; 6:455-463. 235. Scully RE. Gonadoblastoma. A review of 74 cases. Cancer 1970; 25:1340-1356. 3d] [28/8/010/18:1:43] [24-36] 2 Preoperative preparation and surgical instrumentation Michael A. Bidus, G. Scott Rose, and John C. Elkas INTRODUCTION The ...
Seminal Vesicle Cystadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Ovarian serous cystadenofibroma | Radiology Case | Radiopaedia.org
A rare case of paratesticular leiomyosarcoma.
Biliary cystadenoma | Radiology Reference Article | Radiopaedia.org
Institute of Cancer Research Repository - Rare tumours of the testis and paratesticular tissues
Bob's operation date | Northern Lights Rattery - Rats in the Highlands
Collision tumor of the appendix: mucinous cystadenoma and carcinoid. A case report<...
TY - JOUR. T1 - Collision tumor of the appendix. T2 - mucinous cystadenoma and carcinoid. A case report. AU - Dellaportas, D.. AU - Vlahos, Nf. AU - Polymeneas, G.. AU - Gkiokas, G.. AU - Dastamani, C.. AU - Carvounis, E.. AU - Theodosopoulos, T.. PY - 2014. Y1 - 2014. N2 - INTRODUCTION: Mucinous cystadenoma is the most common of benign neoplasms of the appendix and carcinoid is the most common type of primary malignant lesions of the appendix.We report a rare case of a 57-year-old female with combined mucinous cystadenoma and carcinoid tumor of the appendix.Dual carcinoid and epithelial neoplasia is a rare occurrence in the appendix.CASE REPORT: A 57-year-old Caucasian woman presented after incidentally palpating a mass on her right iliac fossa. Imaging modalities revealed a cystic tumor in the right iliac fossa with a diameter of about 8 cm, originating either from the right ovary or the appendix. She underwent laparoscopic surgical exploration, which revealed appendiceal mucocele and ...
Mucinous cystadenoma and cystadenocarcinoma - Herb Kosten Foundation
Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...
Woman's 50-pound ovarian cyst was the largest her docs had seen
What are the clinical findings of neoplastic cysts of the liver?
Vesalius Clinical Folios: Mucinous Cystadenoma of the Appendix
Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies<...
TY - JOUR. T1 - Comprehensive genetic characterization of human thyroid cancer cell lines. T2 - A validated panel for preclinical studies. AU - Landa, Iñigo. AU - Pozdeyev, Nikita. AU - Korch, Christopher. AU - Marlow, Laura A.. AU - Smallridge, Robert Christian. AU - Copland, John A III. AU - Henderson, Ying C.. AU - Lai, Stephen Y.. AU - Clayman, Gary L.. AU - Onoda, Naoyoshi. AU - Tan, Aik Choon. AU - Garcia-Rendueles, Maria E.R.. AU - Knauf, Jeffrey A.. AU - Haugen, Bryan R.. AU - Fagin, James A.. AU - Schweppe, Rebecca E.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Purpose: Thyroid cancer cell lines are valuable models but have been neglected in pancancer genomic studies. Moreover, their misidentification has been a significant problem. We aim to provide a validated dataset for thyroid cancer researchers. Experimental Design: We performed next-generation sequencing (NGS) and analyzed the transcriptome of 60 authenticated thyroid cell lines and compared our findings with the known genomic defects ...
Huge Mucinous Cystadenoma Presenting as an Acute Abdomen in the Puerperium | West Indian Medical Journal
Adnexa masses occur in one out of two hundred pregnancies(1). Many are benign ovarian cysts diagnosed in womenduring antenatal care and managed conservatively with success.Occasionally, ovarian accidents occur that necessitateemergency surgeries. However, in women, unbooked duringpregnancy, presentation to hospital may occur for the firsttime in the puerperium and it may pose
Medicowesome: Pancreatic cysts
Three cases of pancreatic serous cystadenoma and endocrine tumour | Journal of Clinical Pathology
PDGF BB Rat-PDGF
PLOS ONE: AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines
Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the ERK/MAPK, the PI3K/AKT/mTOR and the JAK/STAT3 pathways. Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480. This inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of TPC-1 xenografts, where it efficiently blocked STAT3 activation in tumor and stromal cells. This inhibition was associated with decreased proliferation, decreased blood vessel density, coupled with increased necrosis. However, AZD1480 repressed the growth of STAT3- deficient TPC-1 cells in vitro and in vivo, demonstrating that its effects
Giant paratubal serous cystadenoma in an adolescent female: Case report and literature review.
Paraovarian/paratubal cysts constitute 5-20% of all adnexal lesions and typically originate from the paramesonephric or Müllerian duct. The primary epithelial tumors arising from paraovarian cysts account for 25% of the cases, but giant cystadenomas of paraovarian origin are extremely uncommon during childhood and adolescence with very few cases reported in the literature. We present the case of a 15-year-old female that presented with a bulky mass in the abdomen and pelvis. An initial clinical and radiological examination indicated an ovarian cyst measuring ∼25x20 cm. However, explorative laparotomy revealed a giant paratubal cyst that was successfully treated with complete excision using fertility-sparing surgery. Histopathological examination was consistent with a serous cystadenoma. The postoperative course was uneventful and the girl was discharged on the seventh postoperative day. At the follow-up of six months, the patient was doing well. Due to their rarity and enormous size, the ...
Paratesticular rhabdomyosarcoma: Report from the Italian and German Cooperative Group<...
TY - JOUR. T1 - Paratesticular rhabdomyosarcoma. T2 - Report from the Italian and German Cooperative Group. AU - Ferrari, A.. AU - Bisogno, G.. AU - Casanova, M.. AU - Meazza, C.. AU - Piva, L.. AU - Cecchetto, G.. AU - Zanetti, I.. AU - Pilz, T.. AU - Mattke, A.. AU - Treuner, J.. AU - Carli, M.. PY - 2002/1/15. Y1 - 2002/1/15. N2 - Purpose: We report the experience of the German-Italian Cooperative Group with 216 pediatric patients with paratesticular rhabdomyosarcoma treated over 20 years. Patients and Methods: At diagnosis, 198 patients had localized disease and 18 had distant metastases. Among the nonmetastatic patients, complete tumor resection was performed in 83% of cases. Evaluation of the retroperitoneal lymph nodes changed over the years from routine surgical staging to radiologic assessment. All patients received chemotherapy, which was reduced in intensity and duration for patients with low-risk features in subsequent protocols. Radiotherapy was administered to 10% of patients. ...
Week 298: Case 1 | Johns Hopkins Surgical Pathology Unknown Conference
Answer: Mucinous cystadenoma. Histology: none provided. Discussion: This cystic mass is partially denuded and partially lined by benign mucinous epithelium. The wall is thick and fibrotic with chronic inflammation. Focal areas with aggregates of foamy histiocytes and granulation tissue are also noted in the cyst lumen. No extravasated mucin or ovarian type stroma is identified. The tumor is adherent to the serosal surface/deep aspect of muscularis propria of the colon. The appendix and ascending colon were unremarkable. Immunostains demonstrate that the mucinous epithelium is CK7+, CK20-, and MUC2- but MUC5+ and beta-catenin negative. This staining pattern is most consistent with an ovarian type mucinous neoplasm. Since no ovarian tissue was submitted and as per the surgeon the tumor was away from the ovaries these findings may represent a mucinous cystadenoma arising in ectopic ovarian tissue.. ...
Splenic preservation versus splenectomy in laparoscopic distal pancreatectomy: a propensity score-matched study | SpringerLink
Contralateral testicular metastasis in paratesticular rhabdomyosarcoma<...
TY - JOUR. T1 - Contralateral testicular metastasis in paratesticular rhabdomyosarcoma. AU - Backhaus, Björn O.. AU - Kaefer, Martin. AU - Engum, Scott A.. AU - Davis, Mary M.. PY - 2000. Y1 - 2000. KW - Neoplasm metastasis. KW - Rhabdomyosarcoma. KW - Testis. KW - Ultrasonography. UR - http://www.scopus.com/inward/record.url?scp=0033793373&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033793373&partnerID=8YFLogxK. M3 - Article. C2 - 11025756. AN - SCOPUS:0033793373. VL - 164. SP - 1709. EP - 1710. JO - Journal of Urology. JF - Journal of Urology. SN - 0022-5347. IS - 5. ER - ...
Cystic, mucinous, and serous neoplasms - Wikipedia
Aldred Scott Warthin
Pancreatic mucinous cystic neoplasm
Endolymphatic sac tumor
... papillary adenomatous tumor, aggressive papillary adenoma, invasive papillary cystadenoma, and papillary tumor of temporal bone ... Aug 1993). "Papillary neoplasms (Heffner's tumors) of the endolymphatic sac". Ann Otol Rhinol Laryngol. 102 (8 pt 1): 648-51. ... The tumor is arranged as simple, broad, non-complex papillary projections without large cystic spaces. The spaces are often ... The cells are cuboidal, usually single layered along the papillary structures, showing indistinct cell borders. The nuclei are ...
List of MeSH codes (C04)
... cystadenoma MeSH C04.557.470.035.320.225 --- cystadenoma, mucinous MeSH C04.557.470.035.320.230 --- cystadenoma, papillary MeSH ... cystadenoma MeSH C04.557.470.590.485.225 --- cystadenoma, mucinous MeSH C04.557.470.590.485.230 --- cystadenoma, papillary MeSH ... papillary MeSH C04.557.470.200.025.085.225 --- carcinoma, papillary, follicular MeSH C04.557.470.200.025.095 --- adenocarcinoma ... papillary MeSH C04.557.470.200.400 --- carcinoma, squamous cell MeSH C04.557.470.200.400.130 --- bowen's disease MeSH C04.557. ...
Von Hippel-Lindau disease
... carcinoma Papillary renal cell carcinoma Micropapillary subtype of lung adenocarcinoma Ovarian papillary serous cystadenoma and ... Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ... The term is derived from the Greek word ψάμμος (psámmos), meaning "sand". Psammoma bodies are associated with the papillary ( ... Psammoma bodies are commonly seen in certain tumors such as: Papillary thyroid ...
Cystic lesions of the pancreas
Pancreatic intraductal papillary mucinous tumors (most common diagnosis - 52.6%) Pancreatic serous cystic tumors (20.6%) ... Pancreatic mucinous cystadenoma Pancreatic mucinous cystadenocarcinoma Parra-Herran, C. E.; Garcia, M. T.; Herrera, L; Bejarano ... Pancreatic serous cystadenoma Pancreatic serous cystadenocarcinoma Pancreatic mucinous cystic tumors (13.4%) ...
International Classification of Diseases for Oncology
NOS M8471/0 Papillary mucinous cystadenoma, NOS (C56.9) Papillary pseudomucinous cystadenoma, NOS M8471/3 papillary mucinous ... M8460/0 Papillary serous cystadenoma, NOS (C56.9) M8460/3 Papillary serous cystadenocarcinoma (C56.9) Papillary serous ... Eccrine cystadenoma M8405/0 Papillary hidradenoma Hidradenoma papilliferum M8406/0 Papillary syringadenoma (C44._) Papillary ... NOS Intraductal papillary carcinoma, NOS Ductal carcinoma in situ, papillary DCIS, papillary M8503/3 Intraductal papillary ...
... serous cystadenoma (8441-8442) papillary cystadenoma (8450-8451, 8561) mucinous cystadenoma (8470-8473) Bile duct cystadenoma ( ... ISBN 1-4160-2999-0. Picture of serous cystadenoma Serous cystadenoma of pancreas at eMedicine Biliary cystadenoma/ ... 8161) Endometrioid cystadenoma (8380) Appendiceal mucinous cystadenoma The term "cystadenoma" may also refer to a hidrocystoma ... cystadenocarcinoma at eMedicine - Slide: Papillary Cystadenoma of Epididymis. ...
Papillary serous cystadenocarcinoma
... s may exhibit psammoma bodies upon histopathology. Papillary serous cystadenoma Papillary ... Papillary serous cystadenocarcinomas are the most common form of malignant ovarian cancer making up 26 percent of ovarian ... Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ...
Pancreatic serous cystadenoma
In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and ... Pancreatic serous cystadenoma, also known as serous cystadenoma of the pancreas and serous microcystic adenoma, a benign tumour ... Ovarian serous cystadenoma Pancreatic mucinous cystadenoma Solid pseudopapillary neoplasm Colonna, J.; Plaza, JA.; Frankel, WL ... 2008). "Serous cystadenoma of the pancreas: clinical and pathological features in 33 patients". Pancreatology. 8 (2): 135-41. ...
On gross examination, the serous tumor may present as either a cystic lesion in which the papillary epithelium is contained ... Sixty percent are benign (cystadenoma), 10% are borderline and 30% are malignant (cystadenocarcinoma). Benign serous tumours ... In borderline lesions, the cyst or surface is lined by papillary structures, which are often very complex. Surgery is usually ... They are lined by a complex papillary pattern with presence of nuclear anaplasia. Serous carcinomas often have bulky peritoneal ...
Intraductal papillary mucinous neoplasm
Pancreatic mucinous cystic neoplasm Pancreatic serous cystadenoma Solid pseudopapillary neoplasm "Intraductal Papillary ... Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. IPMN ... Although intraductal papillary mucinous neoplasms are benign tumors, they can progress to pancreatic cancer. As such IPMN is ... Once an intraductal papillary mucinous neoplasm has been found, the management options include close monitoring and pre-emptive ...
Hereditary leiomyomatosis and renal cell cancer syndrome
The renal cell carcinoma tends to be of the papillary (type 2) form and tends to occur more commonly in women than men with ... Two cases of ovarian mucinous cystadenoma have also been reported with this mutation. The fumarate hydratase gene, located on ... skin leiomyomata and papillary renal cell cancer". Nature Genetics. 30 (4): 406-410. doi:10.1038/ng849. PMID 11865300. Bayley, ... "Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type ...
Black hairy tongue
印戒细胞癌 - 维基百科，自由的百科全
胰臟癌 - 維基百科，自由的百科全書
زونا - ویکیپدیا، دانشنامهٔ آزاد
Granulosa cell tumour
Multiple endocrine neoplasia
Burning mouth syndrome
Temporomandibular joint dysfunction
PAPILLARY CYSTADENOMA OF LACRIMAL CARUNCLE | British Journal of Ophthalmology
Pathology Outlines - Papillary cystadenoma
Vascular endothelial growth factor in von Hippel-Lindau syndrome - associated papillary cystadenoma of epididymis (Hum Pathol ... Papillary in foldings project into cystic spaces covered by single to double layered cuboidal / columnar cells *Tubules common ... Useful negative stains include AMACR and RCC antigen, to differentiate from clear cell papillary renal cell carcinoma *CD10 is ... Simple and complex papillary clusters *Tumor cells are monomorphic, with moderate to abundant cytoplasm, well defined ...
Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament, Arising From a Papillary Cystadenoma
Laparoscopic Anatomical Left Hepatectomy for Intrahepatic Bile Duct Papillary Mucinous Cystadenoma With Intraoperative Vascular...
Serous Papillary Cystadenoma Of Ovary: Symptoms & Management
Serous papillary cystadenoma is a fairly common benign tumor of the ovary. It is known to affect women in the age group of 40 ... Risk Factors For Serous Papillary Cystadenoma. The precise cause for the occurrence of the occurrence of serous papillary ... Serous Papillary Cystadenoma Of Ovary: Symptoms & Management Salina Womens Health March 16, 2017. March 15, 2017. ... Serous papillary cystadenoma is a fairly common benign tumor of the ovary which is known to affect women in the age group of 40 ...
Serous cystadenoma (simple and papillary) - All information about cysts
... and papillary (or papillary) cystadenoma. On the inner surface of the latter there are small dense growths resembling warts. ... Papillary cystadenoma may contain not one but several cavities (chambers), often affects both ovaries. All these features make ... Papillary cystadenoma ovary sometimes gives the accumulation of fluid in the abdomen (ascites), which also leads to its ... Serous cystadenoma (simple and papillary). September 15, 2015 by Adam Cooper · September 15, 2015 ...
Benign Parotid Tumors: Significance, Anatomy, Incidence and Etiology
IMSEAR at SEARO: Papillary cystadenoma lymphomatosum: case report and review of literature.
Papillary cystadenoma lymphomatosum: case report and review of literature.. Authors: Karthikeya, Patil. Mahima, V G. Shalini, ... Papillary Cystadenoma Lymphomatosum or Warthins tumour is a unique neoplasm arising almost exclusively in the parotid salivary ... Karthikeya P, Mahima VG, Shalini K. Papillary cystadenoma lymphomatosum: case report and review of literature. Indian Journal ...
Bilateral Papillary Cystadenoma of the Epididymis, Sensorineural Hearing Loss Associated with ELSTs, X-Ray Abnormal: Causes &...
Possible causes include Papillary Cystadenoma of the Kidney, Von Hippel-Lindau Disease, Renal Cell Carcinoma. Check the full ... Bilateral Papillary Cystadenoma of the Epididymis, Sensorineural Hearing Loss Associated with ELSTs, X-Ray Abnormal Symptom ... Genitourinary Internal Genitalia Male: epididymal cyst bilateral papillary cystadenoma of the epididymis bilateral papillary ... Papillary Cystadenoma of the Kidney […] fields, not x-rays, to produce detailed images of the body.[cancer.net] […] sac tumor, ...
Aldred Scott Warthin - Wikipedia
von Hippel-Lindau Disease - Massachusetts General Hospital, Boston, MA
Introduction Warthins tumor, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma, | Discovery and...
Benign Salivary Gland Conditions & Treatments | Otolaryngology |br /|Head & Neck Surgery | Stanford Medicine
A Postmenopausal Woman with Giant Ovarian Serous Cyst Adenoma: A Case Report with Brief Literature Review
M. Dey and N. Pathak, "Giant serous papillary cystadenoma," Medical Journal Armed Forces India, vol. 67, no. 3, pp. 272-273, ... In some instances, they include papillary projections. Giant ovarian serous cyst adenoma is a rare finding. In the literature, ... A Postmenopausal Woman with Giant Ovarian Serous Cyst Adenoma: A Case Report with Brief Literature Review. Nishat Fatema and ... V. V. Sujatha and S. C. Babu, "Giant ovarian serous cystadenoma in a postmenopausal woman: A case report," Cases Journal, vol. ...
Category:Epididymis - Wikimedia Commons
Bajpai M[au] - PubMed - NCBI
Medline ® Abstract for Reference 1 of 'Intraductal papillary mucinous neoplasm of the pancreas (IPMN):...
Vaccine Therapy Combined With Adjuvant Chemoradiotherapy in Treating Patients With Resected Stage I or Stage II Adenocarcinoma ...
Papillary serous cystadenocarcinoma - Wikipedia
Papillary serous cystadenocarcinomas may exhibit psammoma bodies upon histopathology. Papillary serous cystadenoma Papillary ... Papillary serous cystadenocarcinomas are the most common form of malignant ovarian cancer making up 26 percent of ovarian ... Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ...
Ch 7: neoplasia Flashcards by Caitlin miller | Brainscape
Diagnosis of Salivary Gland Disorders Buch portofrei - Weltbild.de
Salivary Gland Cancer: Subtypes | Cancer.Net
Biliary Cystadenoma/Cystadenocarcinoma Imaging: Overview, Radiography, Computed Tomography
Biliary cystadenoma represents a rare benign cystic hepatic neoplasm that has premalignant potential. The tumor originates in ... Papillary projections can be seen with both CT scanning and ultrasonography.. MRI signal characteristics of biliary cystadenoma ... Biliary cystic intraductal papillary mucinous tumor and cystadenoma/cystadenocarcinoma: differentiation by CT. Abdom Imaging. ... encoded search term (Biliary Cystadenoma/Cystadenocarcinoma Imaging) and Biliary Cystadenoma/Cystadenocarcinoma Imaging What to ...
ADK Gene - GeneCards | ADK Protein | ADK Antibody
Table 7. Benign Salivary Gland Tumors | A Guide to Clinical Differential Diagnosis of Oral Mucosal Lesions | Continuing...
Diverse tumorigenic pathways in ovarian serous carcinoma
Benign and Malignant Tumors | A Guide to Clinical Differential Diagnosis of Oral Mucosal Lesions | Continuing Education Course ...
Chapter 11 Flashcards by Ryan Davis | Brainscape
Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders - Full Text View - ClinicalTrials.gov
Papillary cystadenoma of the epididymis or broad ligament. *Endolymphatic sac tumor. *History of spontaneous pneumothorax ... hereditary papillary renal cancer (HPRC), Birt Hogg Dube (BHD) and hereditary leiomyomatosis and renal cell acarcinoma (HLRCC) ... Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet ... specifically hereditary forms of Type II papillary renal cancer, clear cell renal carcinoma, renal oncocytoma, chromophobe ...
- IMSEAR at SEARO: Papillary cystadenoma lymphomatosum: case report and review of literature. (who.int)
- Karthikeya P, Mahima VG, Shalini K. Papillary cystadenoma lymphomatosum: case report and review of literature. (who.int)
- Papillary Cystadenoma Lymphomatosum or Warthin's tumour is a unique neoplasm arising almost exclusively in the parotid salivary gland and is composed of oncocytic epithelium with a prominent lymphoid infiltrate. (who.int)
- Introduction Warthins tumor, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma, or adenolymphoma, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and lymph node-like stroma. (monossabios.com)
- Warthin tumour is also known as papillary cystadenoma lymphomatosum. (cancer.ca)
- Warthin's tumor, also known as papillary cystadenoma lymphomatosum or adenolymphoma , is the second most common benign tumor of the salivary glands . (omicsonline.org)
- Warthin's tumor (papillary cystadenoma lymphomatosum), the next most common benign tumor, accounts for about 5% of parotid tumors. (health.am)
- Other benign tumors include monomorphic adenoma, oncocytoma, and papillary cystadenoma lymphomatosum (previously known as cylindroma). (merckmanuals.com)
- These changes may lead to non-cancerous, or benign, tumours such as pleomorphic adenoma (also called benign mixed tumour) or papillary cystadenoma lymphomatosum (also called Warthin's tumour). (cancer.ca)
- The differential diagnosis includes pleomorphic adenoma, monomorphic adenoma, papillary cystadenoma lymphomatosum (although usually present in older patients) and low-grade adenoid cystic carcinoma and acinic cell carcinoma. (uiowa.edu)
- From the category of salivary gland tumors, papillary cystadenoma lymphomatosum can be excluded because these tumors almost always arise within major salivary glands, especially the parotid glands. (uiowa.edu)
- MRI signal characteristics of biliary cystadenoma/cystadenocarcinoma are not specific for the disease. (medscape.com)
- Papillary serous cystadenoma Papillary serous cystadenocarcinoma of the ovary images: Kosary, Carol L. (2007). (wikipedia.org)
- Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. (wikipedia.org)
- Unfortunately, there are no specific imaging features that permit reliable differentiation of biliary cystadenoma from biliary cystadenocarcinoma . (radiopaedia.org)
- Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma. (radiopaedia.org)
- Cystadenocarcinoma ( papillary cystadenocarcinoma ) of the salivary gland is a rare malignant neoplasm. (labome.org)
- Immunohistochemical and ultrastructural findings in a rare case of papillary cystadenocarcinoma arising from the left sublingual gland of a 55-year-old Japanese man are reported. (labome.org)
- The remaining seven neoplasms in the combined data comprised myoepithelioma, cystadenoma and sialadenoma papilliferum. (springer.com)
- The neoplasms consisted of eight pleomorphic adenomas (PA) and one cystadenoma. (springer.com)
- Intraductal papillary mucinous neoplasms are growths in the pancreatic ductal system. (moffitt.org)
- Cytological criteria of high-grade epithelial atypia in the cyst fluid of pancreatic intraductal papillary mucinous neoplasms. (semanticscholar.org)
- In addition, there are several thyroid neoplasms that should be considered when one observes a Hurthle cell neoplasm in the thyroid (oncocytic variant of medullary carcinoma, several variants of papillary thyroid carcinoma). (redorbit.com)
- The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for CD10, and strong nuclear positivity for GATA3. (ovid.com)
- cystadenoma of epididymis , pheochromocytoma Hereditary papillary renal cell carcinoma Due to activating mutation of MET oncogene at chromosome 7q31 Autosomal dominant, late [pathologyoutlines.com] A chest x - ray and liver function tests are essential. (symptoma.com)
- Individuals and biologic family members with a suspected or an established diagnosis of von Hippel-Lindau (VHL) syndrome or hereditary papillary renal carcinoma (HPRC), Type I. (clinicaltrials.gov)
- Individuals and biologic family members with a suspected or an established diagnosis of an inherited urologic malignancy in which the disease gene is not yet known, specifically hereditary forms of Type II papillary renal cancer, clear cell renal carcinoma, renal oncocytoma, chromophobe renal carcinoma or Birt Hogg Dube syndrome. (clinicaltrials.gov)
- Hereditary kidney cancer syndromes include von Hippel-Lindau disease, hereditary leiomyomatosis and renal cell cancer, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. (oncolink.org)
- and hereditary papillary renal carcinoma (HPRC, caused by pathogenic variants in MET). (oncolink.org)
- Triple expression of GFAP, vimentin and cytokeratins in papillary meningioma and metastasizing renal carcinoma. (springer.com)
- To study the prognosis of patients with stage IIIC/IV primary peritoneal serous papillary carcinoma (PSPC) (study group) compared with that of patients with epithelial ovarian carcinoma (EOC) (control group). (labome.org)
- Biliary cystadenoma represents a rare benign cystic hepatic neoplasm that has premalignant potential. (medscape.com)
- Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT? (radiopaedia.org)
- Acinar cell cystadenoma of the pancreas: a benign neoplasm or non-neoplastic ballooning of acinar and ductal epithelium? (semanticscholar.org)
- Mucinous cystadenoma of the liver is a rare (less than 5%) neoplasm. (biomedcentral.com)
- 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue. (malacards.org)
- Papillary Adenocarcinoma, also known as infiltrating and papillary adenocarcinoma , is related to aggressive digital papillary adenocarcinoma and gastric papillary adenocarcinoma . (malacards.org)
- An important gene associated with Papillary Adenocarcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Development EGFR signaling pathway and Cytoskeletal Signaling . (malacards.org)
- 76 Papillary adenocarcinoma is a histological form of lung cancer that is diagnosed when the malignant. (malacards.org)
- The differential diagnosis includes epididymal cystadenoma, adenocarcinoma of the rete testis, non-Hodgkin's lymphoma, and dilatation of the seminiferous tubules secondary to testicular tumor. (thefreelibrary.com)
- Disorders under investigation are: Autosomal dominant inherited urologic malignant disorders including: von Hippel- Lindau (VHL), hereditary papillary renal cancer (HPRC), Birt Hogg Dube (BHD) and hereditary leiomyomatosis and renal cell acarcinoma (HLRCC) as well as familial renal cancer. (clinicaltrials.gov)
- We tested atorvastatin as a therapy for ( a ) ethylnitrosourea (ENU)-enhanced renal cystadenoma and ( b ) spontaneous liver hemangioma in 129Sv/Jae Tsc2 +/− mice. (aacrjournals.org)
- Pathologic analyses revealed a predominance of renal cystadenoma in ENU-treated and liver hemangioma in non-ENU-treated 129Sv/Jae Tsc2 +/− mice. (aacrjournals.org)
- Following atorvastatin treatment, no significant reduction in tumor size, morphology, or phosphorylated S6 levels was observed for either ENU-associated renal cystadenoma or spontaneous liver hemangioma as compared with the untreated groups. (aacrjournals.org)
- Depending on the specific structure of the wall, the cyst is divided into simple serous cystadenoma (has a smooth, flat surface) and papillary (or papillary) cystadenoma. (allcysts.com)
- This ovarian cyst has different names - simple serous cystadenoma solid wall reliabilily cyst, serous cyst. (allcysts.com)
- As mentioned above, the main difference papillary cistadenomy of the ovary is the presence of papillae on the inner surface of the cyst. (allcysts.com)
- If you still exclude the functional nature of the cyst, the treatment of cystadenoma of the ovary should be only operative. (allcysts.com)
- On histopathological examination, the cyst was confirmed as benign serous cystadenoma of the ovary. (hindawi.com)
- At US, a biliary cystadenoma appears as a unilocular or multilocular cyst with enhanced through transmission. (radiopaedia.org)
- Mural nodules and papillary projections may project into the cyst lumen. (radiopaedia.org)
- The MR signal intensity of biliary cystadenoma is variable on both T1- and T2-weighted images, depending on the content of the cyst fluid. (radiopaedia.org)
- A serous cystadenoma is a benign cyst that can arise anywhere in the pancreas. (moffitt.org)
- We present the first case of acinar cell cystadenoma in a 65-year-old woman, diagnosed pre-operatively by pancreatic cyst fluid cytology and Moray® micro-forceps biopsy. (semanticscholar.org)
- Serous papillary cystadenoma is a fairly common benign tumor of the ovary which is known to affect women in the age group of 40 to 60 years. (simple-remedies.com)
- Serous papillary cystadenoma of ovary is a slow growing tumor and it more often than not manifests as a well defined, painless single mass in the ovary. (simple-remedies.com)
- The Symptoms of serous cystadenoma of the ovary is directly dependent on its size. (allcysts.com)
- Papillary cystadenoma ovary sometimes gives the accumulation of fluid in the abdomen (ascites), which also leads to its increase. (allcysts.com)
- Light micrograph of a section through an ovary showing a serous cystadenoma. (sciencephoto.com)
- Diagnosed with stage 2c papillary serous cystadenoma borderline malignancy of the ovary in 2009. (cancerforums.net)
- Acinar cell cystadenoma is a rare, benign cystic lesion of the pancreas. (semanticscholar.org)
- Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules. (semanticscholar.org)
- Fine needle aspiration cytology of acinar cell cystadenoma of the pancreas. (semanticscholar.org)
Affected by an intrahepatic1
- Postoperative pathological diagnosis was intrahepatic bile duct papillary mucinous cystadenoma. (ovid.com)
- Acinar cell cystadenoma: A challenging cytology diagnosis, facilitated by moray® micro-forceps biopsy. (semanticscholar.org)
- In the absence of a definitive diagnosis despite extensive imaging she underwent preoperative endoscopic biliary drainage followed by a left hemihepatectomy with Roux-en-Y hepaticojejunostomy. (biomedcentral.com)
- Biliary cystadenoma can appear as a unilocular or multilocular cystic intrahepatic mass. (medscape.com)
- An extended left hepatectomy, with common bile duct excision and Roux-en-Y right intrahepatic biliary-enteric anstomosis, was performed. (bmj.com)
- A pathological examination of the specimen revealed an obstruction of the bile duct caused by a biliary mucinous cystadenoma affecting both the intrahepatic and extrahepatic systems. (biomedcentral.com)
- Biliary mucinous cystadenoma rarely present with obstructive jaundice affecting both intrahepatic and extrahepatic ducts. (biomedcentral.com)
- We report the case of a woman presenting with obstructive jaundice caused by an intrahepatic biliary cystadenoma. (biomedcentral.com)
- After undergoing an en-block hepatic and bile duct resection, this patient is doing well without signs of recurrent disease. (bmj.com)
- We present a rare case of biliary cystadenoma with both intra and extrahepatic bile duct involvement. (bmj.com)
- The '*' indicates the mucinous cystadenoma within the dilated common bile duct. (biomedcentral.com)