Cystadenocarcinoma
Cystadenocarcinoma, Mucinous
Cystadenoma
Cystadenocarcinoma, Papillary
Cystadenocarcinoma, Serous
Cystadenoma, Mucinous
Mucocele
Cysts
Pyonephrosis
Mixed Tumor, Mesodermal
Ovarian Neoplasms
Biliary Tract Neoplasms
Barium Sulfate
Pseudomyxoma Peritonei
Bile Ducts, Intrahepatic
Retroperitoneal Neoplasms
Pancreatic Neoplasms
Tomography, X-Ray Computed
Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. (1/526)
The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIalpha subunit of type I PKA is elevated in a variety of human tumours and cancer cell lines. The purpose of this study was to assess the prognostic importance of RIalpha expression in patients with ovarian cancer. We have evaluated the expression of RIalpha in a panel of human ovarian tumours (n = 40) and five human ovarian cancer cell lines using quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The human ovarian cell lines OAW42 and OTN14 express high endogenous levels of RIalpha mRNA and protein (at significantly higher mRNA levels than high tissue expressors, P < 0.05). The ovarian cell line A2780 expresses low endogenous levels of RIalpha mRNA and protein (also at higher mRNA levels than low tissue expressors, P < 0.05). Quantitative RT-PCR revealed no significant difference in RIalpha mRNA expression between different ovarian histological subtypes in this study. No associations were found between RIalpha mRNA expression and differentiation state. RIalpha mRNA expression was significantly associated with tumour stage (P = 0.0036), and this remained significant in univariate analysis (P = 0.0002). A trend emerged between RIalpha mRNA expression levels and overall survival in univariate analysis (P = 0.051), however, by multivariate analysis, stage remained the major determinant of overall survival (P = 0.0001). This study indicates that in ovarian epithelial tumours high RIalpha mRNA expression is associated with advanced stage disease. RIalpha expression may be of predictive value in ovarian cancer and may be associated with dysfunctional signalling pathways in this cancer type. (+info)The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPbeta during epithelial tumour progression. (2/526)
The CCAAT/enhancer binding protein (C/EBP) family of transcription factors is involved in metabolism and differentiation of cells, especially in rodent liver cells and adipocytes. Their roles in vivo and in particular during pathophysiological conditions in humans are largely unknown. We have investigated the presence of C/EBPalpha, -beta, -delta and -zeta in normal ovaries and in epithelial ovarian tumours of different stages. Immunohistochemical experiments demonstrated that C/EBPalpha and C/EBPbeta were preferentially expressed in epithelial/tumour cells irrespective of stage or grade of the tumour. C/EBPbeta was located in the nuclei of the cells, in contrast to C/EBPalpha, which was present only in the cytoplasm of these cells. The nuclear localization of C/EBPbeta indicates an active role of this transcription factor in tumour cells, whereas the cytoplasmic distribution suggests a more passive function of C/EBPalpha. C/EBPdelta and -zeta demonstrated a more diverse distribution with predominant localization to epithelial cells, but stromal distribution was also noted. The intracellular distribution was confined to both the nucleus and the cytoplasm for C/EBPdelta and -zeta. Western blotting demonstrated that C/EBPalpha, -beta, -delta and -zeta were present in a majority of the samples. The amount of C/EBPbeta increased markedly with malignancy, i.e. with degree of dedifferentiation, while the other members of the C/EBP family displayed a more constant expression level. These results demonstrate an association between the expression of members of the C/EBP family and the formation of epithelial ovarian tumours, with C/EBPbeta as a potential marker for these tumours. As C/EBPbeta is known to be expressed during proliferation of cells in vitro, it may participate in the proliferative process of ovarian epithelial tumour cells in vivo and play a central role in tumour progression. (+info)Overexpression of H-Ryk in mouse fibroblasts confers transforming ability in vitro and in vivo: correlation with up-regulation in epithelial ovarian cancer. (3/526)
Abnormalities in the function of receptor tyrosine kinases (RTKs) have been demonstrated to be important in the pathogenesis of cancer. H-Ryk, a new member of the RTK family, is an unusual RTK in that it is catalytically inactive because of amino acid substitutions of conserved residues in the catalytic domain. We show by immunohistochemistry that it is expressed in the epithelium, stroma, and blood vessels of normal tissues. Evaluation of a panel of 33 primary ovarian tumors (2 benign, 8 borderline, and 23 malignant) was performed. H-Ryk was overexpressed in borderline and malignant ovarian tumors. In serous and clear cell subtypes, there was increased expression in the epithelium, stroma, and blood vessels. Consistent with this observation, overexpression of H-Ryk in the mouse fibroblast cell line NIH3T3 induces anchorage-independent growth and tumorigenicity in nude mice. This implies that overexpression of the receptor can be transforming and may therefore be significant in the pathogenesis of ovarian cancer. (+info)Borderline ovarian tumours in Vaud, Switzerland: incidence, survival and second neoplasms. (4/526)
Between 1976 and 1996, 176 borderline ovarian tumours were registered in the Cancer Registry of the Swiss canton of Vaud, corresponding to an age-adjusted incidence (world standard) of 2.7 in 100,000. Incidence rose from 1.7 per 100,000 during 1976-81 to 2.7 per 100,000 during 1987-91, and then levelled off; 58% of cases were serous and 41% mucinous. Relative survival was 94% at 10 years; 18 second neoplasms were observed, compared with 10.3 expected, and there was a significant excess of invasive ovarian cancers (four observed, including three synchronous, compared with 0.4 expected). (+info)Three dimensional ultrasound and power doppler in assessment of uterine and ovarian angiogenesis: a prospective study. (5/526)
AIM: To determine whether three-dimensional power Doppler can improve the recognition of pelvic tumor morphology and angiogenesis. METHODS: Using this technique we analyzed 180 adnexal masses and 110 uterine lesions. Tumor volume, morphology, and vascularity were evaluated in each patient. Irregular and randomly dispersed vessels with complex branching depicted by comprehensive three dimensional display were suggestive of pelvic malignancy, while linear-like vascular morphology, single vessel arrangement and regular branching were typical for benign structures. RESULTS: Addition of qualitative analysis of vascular architecture of adnexal tumor to morphological parameters reached 96.15% sensitivity and 98.73% specificity. When endometrial lesions were prospectively analyzed, sensitivity and specificity were 91.67% and 98.49%, respectively. Because the lowest positive predictive value of 16.67% was obtained for myometrial lesions, this method should not be advised for their eva luation. CONCLUSION: Good results achieved by three dimensional ultrasound can be explained by improved recognition of the pelvic lesion anatomy, characterization of the surface features, detection of the tumor infiltration, and precise depiction of the size and volume. Three dimensional power Doppler imaging can detect structural abnormalities of the malignant tumor vessels, such as arteriovenous shunts, microaneurysms, tumoral lakes, disproportional calibration, coiling, and dichotomous branching. Therefore it enhances and facilitates the morphologic and functional evaluation of both benign and malignant pelvic tumors. (+info)Evaluation of the tyrosine kinase domain of the Met proto-oncogene in sporadic ovarian carcinomas*. (6/526)
Most of the ovarian cancers originate from the ovarian surface epithelium derived from the coelomic mesothelium. The Met proto-oncogene encodes a transmembrane tyrosine kinase receptor (Met) that has the capacity to regulate cell proliferation and differentation and it is activated by hepatocyte growth factor. Trisomy of chromosome 7 and Met protein overexpression have been were observed in ovarian carcinomas, the papillary renal cancers and other solid tumors. Frequent mutations of Met proto-oncogene have been found in hereditary papillary renal cancer (HPRC) and most of the mutations are located in the tyrosine kinase domain. The aim of this study to perform a mutation analysis of exons 17 19 of Met proto-oncogene in epithelial ovarian tumors (EOTs). We have examined 24 tumor samples from patients, operated with EOTs. Mutation was detected in exon 18 in only one sample of 24 EOTs. Our results indicate that mutations located in the Met proto-oncogene is not a common event in EOT. It is not clear whether the mutation plays a role in the tumorigenesis or progression of EOT or not. (+info)Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors. (7/526)
The purpose of this study was to investigate the frequency of p53 overexpression in the primary ovarian tumors of patients with stages II and III serous borderline tumors (SBTs) and to determine the relationship between p53 overexpression and risk of progression/recurrence and survival. Of 112 patients with stages II-IV SBTs, paraffin-embedded tissue from the primary ovarian tumor was available in 68 cases. Immunohistochemical staining for p53 was performed. Clinical information was abstracted from the medical records. The major end points selected for analysis were time to progression/relapse, disease-free survival, overall survival, and cause-specific survival. Univariate and multivariate regression analyses were also performed. The median patient age was 37 years (range, 17-67 years). Twenty-two patients had stage II disease, and 46 had stage III disease. The mean follow-up time was 105 months. Nineteen patients (28%) had either disease progression (1 patient) or relapse (18 patients). Eleven patients died: 10 patients died of their tumor, and 1 patient died of other causes. Thirteen cases (19%) had positive immunostaining for p53. Overexpression of p53 was significantly associated with an increased probability of progression/recurrence (P = 0.005) and a decreased overall survival (P = 0.012). After adjusting for age, International Federation of Gynecology and Obstetrics (FIGO) stage, the presence of residual tumor, and the presence of invasive implants, patients whose tumors overexpressed p53 had a 4-fold increased risk of progression/ recurrence. Similarly, women whose tumor overexpressed p53 had an approximately 6-fold increased risk of death. p53 overexpression in the ovarian tumors of patients with stage II and III SBTs is significantly associated with increased probability of relapse and decreased overall survival. This information should provide better prognostic data to patients and their families and allow us to select patients who might benefit from postoperative treatment. (+info)Allelotyping defines minimal imbalance at chromosomal region 17q25 in non-serous epithelial ovarian cancers. (8/526)
Allelic deletions of multiple chromosome 17q loci in sporadic ovarian cancer of epithelial origin suggest that inactivation of tumor suppressor gene(s) in these regions may be important for ovarian tumorigenesis. To further define the pattern of allelic imbalance in epithelial ovarian tumors of different histologies, a PCR-based assay was used to assess loss of heterozygosity (LOH) of polymorphic markers representative of TP53, BRCA1, NME1 and GH1, and region 17q23-25. LOH was observed for at least one marker in 68% of malignant tumors (n=60) and in 18% tumors of borderline malignancy (n=11), but not in benign tumors (n=5). The highest frequency of LOH in malignant tumors (64%) was observed with D17S801 on 17q25. Ten of 39 malignant ovarian tumors displaying LOH of at least one 17q marker, displayed a LOH pattern enabling the determination of a minimal region of overlapping deletion defined by D17S795 and D17S801. One borderline tumor also displayed an interstitial LOH pattern that overlapped this 17q25 minimal region of deletion. The histologies of malignant tumors displaying a pattern indicative of interstitial 17q deletions were of the endometrioid, clear cell and mucinous epithelial types. As the minimal region of overlap defined by these tumors overlap regions deleted in malignant tumors of all histologic types, and in a tumor of borderline malignancy, the 17q25-tumor suppressor may be implicated in the development of all types of epithelial ovarian tumors. (+info)Cystadenocarcinoma is a type of tumor that arises from the epithelial lining of a cyst, and it has the potential to invade surrounding tissues and spread (metastasize) to other parts of the body. It typically affects glandular organs such as the ovaries, pancreas, and salivary glands.
Cystadenocarcinomas can be classified into two types: serous and mucinous. Serous cystadenocarcinomas produce a watery fluid, while mucinous cystadenocarcinomas produce a thick, mucus-like fluid. Both types of tumors can be benign or malignant, but malignant cystadenocarcinomas are more aggressive and have a higher risk of metastasis.
Symptoms of cystadenocarcinoma depend on the location and size of the tumor. In some cases, there may be no symptoms until the tumor has grown large enough to cause pain or other problems. Treatment typically involves surgical removal of the tumor, along with any affected surrounding tissue. Chemotherapy and radiation therapy may also be used in some cases to help prevent recurrence or spread of the cancer.
Mucinous cystadenocarcinoma is a type of cancer that arises from the mucin-producing cells in the lining of a cyst. It is a subtype of cystadenocarcinoma, which is a malignant tumor that develops within a cyst. Mucinous cystadenocarcinomas are typically found in the ovary or pancreas but can also occur in other organs such as the appendix and the respiratory tract.
These tumors are characterized by the production of large amounts of mucin, a gel-like substance that can accumulate within the cyst and cause it to grow. Mucinous cystadenocarcinomas tend to grow slowly but can become quite large and may eventually spread (metastasize) to other parts of the body if left untreated.
Symptoms of mucinous cystadenocarcinoma depend on the location and size of the tumor, but they may include abdominal pain or discomfort, bloating, changes in bowel movements, or vaginal bleeding. Treatment typically involves surgical removal of the tumor, followed by chemotherapy or radiation therapy to kill any remaining cancer cells. The prognosis for mucinous cystadenocarcinoma depends on several factors, including the stage of the disease at diagnosis and the patient's overall health.
Cystadenoma is a type of benign tumor (not cancerous), which arises from glandular epithelial cells and is covered by a thin layer of connective tissue. These tumors can develop in various locations within the body, including the ovaries, pancreas, and other organs that contain glands.
There are two main types of cystadenomas: serous and mucinous. Serous cystadenomas are filled with a clear or watery fluid, while mucinous cystadenomas contain a thick, gelatinous material. Although they are generally not harmful, these tumors can grow quite large and cause discomfort or other symptoms due to their size or location. In some cases, cystadenomas may undergo malignant transformation and develop into cancerous tumors, known as cystadenocarcinomas. Regular medical follow-up and monitoring are essential for individuals diagnosed with cystadenomas to ensure early detection and treatment of any potential complications.
Papillary cystadenocarcinoma is a type of cancer that arises from the epithelial cells lining a cyst. It is called "papillary" because the tumor has finger-like projections called papillae, which are made up of fibrovascular cores covered by neoplastic cells.
Cystadenocarcinoma is a malignant tumor that has the potential to invade surrounding tissues and spread (metastasize) to other parts of the body. Papillary cystadenocarcinomas can occur in various organs, including the ovaries, pancreas, and lungs.
The symptoms of papillary cystadenocarcinoma depend on the location of the tumor. For example, an ovarian papillary cystadenocarcinoma may cause abdominal pain or bloating, while a lung papillary cystadenocarcinoma may cause coughing or shortness of breath.
The diagnosis of papillary cystadenocarcinoma typically involves imaging tests such as ultrasound, CT scan, or MRI, followed by a biopsy to confirm the presence of cancer cells. Treatment options include surgery to remove the tumor, chemotherapy, and radiation therapy. The prognosis for papillary cystadenocarcinoma depends on several factors, including the stage of the disease at diagnosis, the location of the tumor, and the patient's overall health.
Cystadenocarcinoma, serous is a type of cystic tumor that arises from the lining of the abdominal or pelvic cavity (the peritoneum). It is called "serous" because the tumor cells produce a thin, watery fluid similar to serum.
Cystadenocarcinoma is a malignant (cancerous) tumor that can invade surrounding tissues and spread (metastasize) to other parts of the body. It typically affects women over the age of 50 and can cause symptoms such as abdominal pain, bloating, and changes in bowel or bladder habits.
Serous cystadenocarcinoma is a subtype of ovarian cancer that arises from the surface of the ovary. It can also occur in other organs, including the fallopian tubes, peritoneum, and endometrium. This type of tumor tends to grow slowly but can spread widely throughout the abdominal cavity, making it difficult to treat.
Treatment for serous cystadenocarcinoma typically involves surgery to remove the tumor and any affected tissues, followed by chemotherapy to kill any remaining cancer cells. The prognosis for this type of cancer depends on several factors, including the stage of the disease at diagnosis, the patient's age and overall health, and the response to treatment.
Mucinous cystadenoma is a type of benign tumor that arises from the epithelial cells lining the mucous membranes of the body. It is most commonly found in the ovary, but can also occur in other locations such as the pancreas or appendix.
Mucinous cystadenomas are characterized by the production of large amounts of mucin, a slippery, gel-like substance that accumulates inside the tumor and causes it to grow into a cystic mass. These tumors can vary in size, ranging from a few centimeters to over 20 centimeters in diameter.
While mucinous cystadenomas are generally benign, they have the potential to become cancerous (mucinous cystadenocarcinoma) if left untreated. Symptoms of mucinous cystadenoma may include abdominal pain or swelling, bloating, and changes in bowel movements or urinary habits. Treatment typically involves surgical removal of the tumor.
Appendiceal neoplasms refer to various types of tumors that can develop in the appendix, a small tube-like structure attached to the large intestine. These neoplasms can be benign or malignant and can include:
1. Adenomas: These are benign tumors that arise from the glandular cells lining the appendix. They are usually slow-growing and may not cause any symptoms.
2. Carcinoids: These are neuroendocrine tumors that arise from the hormone-producing cells in the appendix. They are typically small and slow-growing, but some can be aggressive and spread to other parts of the body.
3. Mucinous neoplasms: These are tumors that produce mucin, a slippery substance that can cause the appendix to become distended and filled with mucus. They can be low-grade (less aggressive) or high-grade (more aggressive) and may spread to other parts of the abdomen.
4. Adenocarcinomas: These are malignant tumors that arise from the glandular cells lining the appendix. They are relatively rare but can be aggressive and spread to other parts of the body.
5. Pseudomyxoma peritonei: This is a condition in which mucin produced by an appendiceal neoplasm leaks into the abdominal cavity, causing a jelly-like accumulation of fluid and tissue. It can be caused by both benign and malignant tumors.
Treatment for appendiceal neoplasms depends on the type and stage of the tumor, as well as the patient's overall health. Treatment options may include surgery, chemotherapy, or radiation therapy.
A mucocele is a mucus-containing cystic lesion that results from the accumulation of mucin within a damaged minor salivary gland duct or mucous gland. It is typically caused by trauma, injury, or blockage of the duct. Mucocele appears as a round, dome-shaped, fluid-filled swelling, which may be bluish or clear in color. They are most commonly found on the lower lip but can also occur on other areas of the oral cavity. Mucocele is generally painless unless it becomes secondarily infected; however, it can cause discomfort during speaking, chewing, or swallowing, and may affect aesthetics. Treatment usually involves surgical excision of the mucocele to prevent recurrence.
A cyst is a closed sac, having a distinct membrane and division between the sac and its surrounding tissue, that contains fluid, air, or semisolid material. Cysts can occur in various parts of the body, including the skin, internal organs, and bones. They can be caused by various factors, such as infection, genetic predisposition, or blockage of a duct or gland. Some cysts may cause symptoms, such as pain or discomfort, while others may not cause any symptoms at all. Treatment for cysts depends on the type and location of the cyst, as well as whether it is causing any problems. Some cysts may go away on their own, while others may need to be drained or removed through a surgical procedure.
Pyonephrosis is a medical condition characterized by the presence of pus in the renal pelvis, which is the part of the kidney where urine collects before flowing into the ureter. This occurs as a result of a severe infection that has spread to the kidney and caused pus to accumulate within the renal pelvis. Pyonephrosis can lead to serious complications such as sepsis, kidney damage, or even kidney failure if left untreated. It is typically treated with antibiotics and may require surgical intervention to drain the pus and remove any infected tissue.
A "mixed tumor, mesodermal" is not a widely recognized or currently used medical term in pathology. However, based on the context, it may refer to a type of tumor that contains a mixture of different cell types derived from the mesoderm, one of the three primary germ layers during embryonic development.
In general, a mixed tumor is a tumor composed of more than one type of tissue or cell type. In the context of soft tissue tumors, a "mixed tumor" may refer to a tumor with elements of both epithelial and mesenchymal differentiation, such as a pleomorphic adenoma.
However, in the context of mesodermal tissues, mixed tumors are not typically used to describe soft tissue tumors. Instead, the term "mixed" is more commonly used in the classification of certain types of ovarian tumors that contain both epithelial and mesenchymal elements, such as a Brenner tumor or a mullerian mixed tumor.
Therefore, it's important to provide more context or specify the body site when using the term "mixed tumor, mesodermal" to ensure accurate communication and understanding.
Ovarian neoplasms refer to abnormal growths or tumors in the ovary, which can be benign (non-cancerous) or malignant (cancerous). These growths can originate from various cell types within the ovary, including epithelial cells, germ cells, and stromal cells. Ovarian neoplasms are often classified based on their cell type of origin, histological features, and potential for invasive or metastatic behavior.
Epithelial ovarian neoplasms are the most common type and can be further categorized into several subtypes, such as serous, mucinous, endometrioid, clear cell, and Brenner tumors. Some of these epithelial tumors have a higher risk of becoming malignant and spreading to other parts of the body.
Germ cell ovarian neoplasms arise from the cells that give rise to eggs (oocytes) and can include teratomas, dysgerminomas, yolk sac tumors, and embryonal carcinomas. Stromal ovarian neoplasms develop from the connective tissue cells supporting the ovary and can include granulosa cell tumors, thecomas, and fibromas.
It is essential to diagnose and treat ovarian neoplasms promptly, as some malignant forms can be aggressive and potentially life-threatening if not managed appropriately. Regular gynecological exams, imaging studies, and tumor marker tests are often used for early detection and monitoring of ovarian neoplasms. Treatment options may include surgery, chemotherapy, or radiation therapy, depending on the type, stage, and patient's overall health condition.
Biliary tract neoplasms refer to abnormal growths or tumors that develop in the biliary system, which includes the gallbladder, bile ducts inside and outside the liver, and the ducts that connect the liver to the small intestine. These neoplasms can be benign (non-cancerous) or malignant (cancerous).
Malignant biliary tract neoplasms are often referred to as cholangiocarcinoma if they originate in the bile ducts, or gallbladder cancer if they arise in the gallbladder. These cancers are relatively rare but can be aggressive and difficult to treat. They can cause symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, weight loss, and dark urine.
Risk factors for biliary tract neoplasms include chronic inflammation of the biliary system, primary sclerosing cholangitis, liver cirrhosis, hepatitis B or C infection, parasitic infections, and certain genetic conditions. Early detection and treatment can improve outcomes for patients with these neoplasms.
Papillary cystadenoma is a type of benign (non-cancerous) tumor that arises from the glandular cells in various organs. It is characterized by the growth of finger-like projections (papillae) inside the cysts. These tumors can occur in different parts of the body, including the ovaries, pancreas, and the lining of the abdominal cavity (peritoneum).
In general, papillary cystadenomas are slow-growing and do not typically spread to other organs. However, they can cause symptoms such as pain or discomfort if they become large enough to press on surrounding tissues. Treatment usually involves surgical removal of the tumor. It is important to note that while papillary cystadenomas are generally benign, there is a small risk that they may undergo malignant transformation and develop into cancerous tumors over time. Regular follow-up with a healthcare provider is recommended to monitor for any changes in the tumor or the development of new symptoms.
Parotid neoplasms refer to abnormal growths or tumors in the parotid gland, which is the largest of the salivary glands and is located in front of the ear and extends down the neck. These neoplasms can be benign (non-cancerous) or malignant (cancerous).
Benign parotid neoplasms are typically slow-growing, painless masses that may cause facial asymmetry or difficulty in chewing or swallowing if they become large enough to compress surrounding structures. The most common type of benign parotid tumor is a pleomorphic adenoma.
Malignant parotid neoplasms, on the other hand, are more aggressive and can invade nearby tissues and spread to other parts of the body. They may present as rapidly growing masses that are firm or fixed to surrounding structures. Common types of malignant parotid tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, and squamous cell carcinoma.
The diagnosis of parotid neoplasms typically involves a thorough clinical evaluation, imaging studies such as CT or MRI scans, and fine-needle aspiration biopsy (FNAB) to determine the nature of the tumor. Treatment options depend on the type, size, and location of the neoplasm but may include surgical excision, radiation therapy, and chemotherapy.
Barium sulfate is a medication that is commonly used as a contrast material in medical imaging procedures, such as X-rays and CT scans. It works by coating the inside of the digestive tract, making it visible on an X-ray or CT scan and allowing doctors to see detailed images of the stomach, intestines, and other parts of the digestive system.
Barium sulfate is a white, chalky powder that is mixed with water to create a thick, milky liquid. It is generally safe and does not cause significant side effects when used in medical imaging procedures. However, it should not be taken by individuals who have a known allergy to barium or who have certain digestive conditions, such as obstructions or perforations of the bowel.
It's important to note that while barium sulfate is an important tool for medical diagnosis, it is not a treatment for any medical condition and should only be used under the direction of a healthcare professional.
Pseudomyxoma Peritonei (PMP) is a rare, slow-growing, and invasive cancer that typically starts in the appendix as a low-grade mucinous neoplasm, although it can also arise from other organs of the abdominal cavity. The primary characteristic of PMP is the accumulation of copious amounts of gelatinous ascites (peritoneal fluid containing mucin) within the peritoneal cavity, causing progressive abdominal distension and discomfort.
The condition is classified into three main histological subtypes: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and hybrid tumors. DPAM is the least aggressive form, while PMCA is more invasive and has a worse prognosis.
The primary treatment for Pseudomyxoma Peritonei involves cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC). This approach aims to remove all visible tumors and destroy any remaining cancer cells within the abdominal cavity. Early diagnosis and aggressive treatment can significantly improve the prognosis for patients with PMP, although long-term survival rates remain variable due to the disease's rarity and heterogeneity.
Intrahepatic bile ducts are the small tubular structures inside the liver that collect bile from the liver cells (hepatocytes). Bile is a digestive fluid produced by the liver that helps in the absorption of fats and fat-soluble vitamins from food. The intrahepatic bile ducts merge to form larger ducts, which eventually exit the liver and join with the cystic duct from the gallbladder to form the common bile duct. The common bile duct then empties into the duodenum, the first part of the small intestine, where bile aids in digestion. Intrahepatic bile ducts can become obstructed or damaged due to various conditions such as gallstones, tumors, or inflammation, leading to complications like jaundice, liver damage, and infection.
Bile duct neoplasms, also known as cholangiocarcinomas, refer to a group of malignancies that arise from the bile ducts. These are the tubes that carry bile from the liver to the gallbladder and small intestine. Bile duct neoplasms can be further classified based on their location as intrahepatic (within the liver), perihilar (at the junction of the left and right hepatic ducts), or distal (in the common bile duct).
These tumors are relatively rare, but their incidence has been increasing in recent years. They can cause a variety of symptoms, including jaundice, abdominal pain, weight loss, and fever. The diagnosis of bile duct neoplasms typically involves imaging studies such as CT or MRI scans, as well as blood tests to assess liver function. In some cases, a biopsy may be necessary to confirm the diagnosis.
Treatment options for bile duct neoplasms depend on several factors, including the location and stage of the tumor, as well as the patient's overall health. Surgical resection is the preferred treatment for early-stage tumors, while chemotherapy and radiation therapy may be used in more advanced cases. For patients who are not candidates for surgery, palliative treatments such as stenting or bypass procedures may be recommended to relieve symptoms and improve quality of life.
Retroperitoneal neoplasms refer to abnormal growths or tumors that develop in the retroperitoneal space. This is the area located behind the peritoneum, which is the membrane that lines the abdominal cavity and covers the abdominal organs. The retroperitoneal space contains several vital structures such as the kidneys, adrenal glands, pancreas, aorta, and lymphatic vessels.
Retroperitoneal neoplasms can be benign or malignant (cancerous). Malignant retroperitoneal neoplasms are often aggressive and can invade surrounding tissues and organs, leading to various complications. Common types of retroperitoneal neoplasms include lymphomas, sarcomas, and metastatic tumors from other primary sites. Symptoms may vary depending on the size and location of the tumor but can include abdominal or back pain, weight loss, and swelling in the legs. Diagnosis typically involves imaging studies such as CT scans or MRI, followed by a biopsy to determine the type and grade of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.
The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.
CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.
In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.
CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.
In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.
Salivary gland neoplasms refer to abnormal growths or tumors that develop in the salivary glands. These glands are responsible for producing saliva, which helps in digestion, lubrication of food and maintaining oral health. Salivary gland neoplasms can be benign (non-cancerous) or malignant (cancerous).
Benign neoplasms are slow-growing and typically do not spread to other parts of the body. They may cause symptoms such as swelling, painless lumps, or difficulty swallowing if they grow large enough to put pressure on surrounding tissues.
Malignant neoplasms, on the other hand, can be aggressive and have the potential to invade nearby structures and metastasize (spread) to distant organs. Symptoms of malignant salivary gland neoplasms may include rapid growth, pain, numbness, or paralysis of facial nerves.
Salivary gland neoplasms can occur in any of the major salivary glands (parotid, submandibular, and sublingual glands) or in the minor salivary glands located throughout the mouth and throat. The exact cause of these neoplasms is not fully understood, but risk factors may include exposure to radiation, certain viral infections, and genetic predisposition.
A pancreatectomy is a surgical procedure in which all or part of the pancreas is removed. There are several types of pancreatectomies, including:
* **Total pancreatectomy:** Removal of the entire pancreas, as well as the spleen and nearby lymph nodes. This type of pancreatectomy is usually done for patients with cancer that has spread throughout the pancreas or for those who have had multiple surgeries to remove pancreatic tumors.
* **Distal pancreatectomy:** Removal of the body and tail of the pancreas, as well as nearby lymph nodes. This type of pancreatectomy is often done for patients with tumors in the body or tail of the pancreas.
* **Partial (or segmental) pancreatectomy:** Removal of a portion of the head or body of the pancreas, as well as nearby lymph nodes. This type of pancreatectomy is often done for patients with tumors in the head or body of the pancreas that can be removed without removing the entire organ.
* **Pylorus-preserving pancreaticoduodenectomy (PPPD):** A type of surgery used to treat tumors in the head of the pancreas, as well as other conditions such as chronic pancreatitis. In this procedure, the head of the pancreas, duodenum, gallbladder, and bile duct are removed, but the stomach and lower portion of the esophagus (pylorus) are left in place.
After a pancreatectomy, patients may experience problems with digestion and blood sugar regulation, as the pancreas plays an important role in these functions. Patients may need to take enzyme supplements to help with digestion and may require insulin therapy to manage their blood sugar levels.
Hydroxy acids are a class of chemical compounds that contain both a carboxylic acid group and a hydroxyl group. They are commonly used in dermatology and cosmetic products for their exfoliating, moisturizing, and anti-aging properties. The two main types of hydroxy acids used in skincare are alpha-hydroxy acids (AHAs) and beta-hydroxy acids (BHAs).
Alpha-hydroxy acids include compounds such as glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid. They work by breaking down the "glue" that holds dead skin cells together, promoting cell turnover and helping to improve the texture and tone of the skin. AHAs are also known for their ability to improve the appearance of fine lines, wrinkles, and age spots.
Beta-hydroxy acids, on the other hand, are primarily represented by salicylic acid. BHAs are oil-soluble, which allows them to penetrate deeper into the pores and exfoliate dead skin cells and excess sebum that can lead to clogged pores and acne breakouts.
It is important to note that hydroxy acids can cause skin irritation and sensitivity to sunlight, so it is recommended to use sunscreen and start with lower concentrations when first incorporating them into a skincare routine.
Pancreaticoduodenectomy, also known as the Whipple procedure, is a complex surgical operation that involves the removal of the head of the pancreas, the duodenum (the first part of the small intestine), the gallbladder, and the distal common bile duct. In some cases, a portion of the stomach may also be removed. The remaining parts of the pancreas, bile duct, and intestines are then reconnected to allow for the digestion of food and drainage of bile.
This procedure is typically performed as a treatment for various conditions affecting the pancreas, such as tumors (including pancreatic cancer), chronic pancreatitis, or traumatic injuries. It is a major surgical operation that requires significant expertise and experience to perform safely and effectively.
Serous cystadenocarcinoma
Papillary serous cystadenocarcinoma
Ovarian serous cystadenoma
Fibroblast growth factor receptor 1
Cystadenocarcinoma
Pancreatic serous cystadenoma
Psammoma body
Ovarian cancer
SK-OV-3
Leukotriene B4 receptor 2
Estrogen receptor beta
Surface epithelial-stromal tumor
List of MeSH codes (C04)
Pancreatectomy
International Cancer Genome Consortium
International Classification of Diseases for Oncology
Cystadenoma
The Cancer Genome Atlas
Cystic lesions of the pancreas
Mucinous cystadenoma
Serous cystadenocarcinoma - Wikipedia
Serous ovarian cystadenocarcinoma | Radiology Case | Radiopaedia.org
Ovarian serous cystadenocarcinoma (Concept Id: C0279663) - MedGen - NCBI
Mutational signatures are markers of drug sensitivity of cancer cells | Nature Communications
Estimation of prognostic marker genes by public microarray data in patients with ovarian serous cystadenocarcinoma<...
Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That...
Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma
Reclassification of serous ovarian carcinoma by a 2-tier system: a Gynecologic Oncology Group Study
Testicular Cancer - EPIDEMIOLOGY AETIOLOGY PATHOLOGY - Uroweb
Pelvic Masses Including Ovary, Tube and Uterus
Unique Presentation of Giant Metastatic Microcystic Serous Adenocarcinoma of the Pancreas
Pancreatic Pseudocysts: Practice Essentials, Background, Pathophysiology
Long non‑coding RNA DLEU1 promotes cell proliferation of glioblastoma multiforme
UBE4A ubiquitination factor E4A [Homo sapiens (human)] - Gene - NCBI
K Deodhar | West Indian Medical Journal
US Quiz of the Month - April 2019 - Sociedade Portuguesa de Gastrenterologia
Priv.-Doz. Dr. med. Formentini | Universitätsklinikum Ulm
The prognostic potential of alternative transcript isoforms across human tumors | bioRxiv
Ovarian Clear Cell Carcinoma in Cowden Syndrome in: Journal of the National Comprehensive Cancer Network Volume 17 Issue 1 ...
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RFA-CA-15-018: Genomic Data Analysis Network: Processing Genomic Data Center (U24)
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Ubiquitin E3 ligases in cancer: somatic mutation and amplification
Antioxidants - Pine Street Foundation
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HuGE Navigator|Genopedia|PHGKB
Modi-1 in Breast, Head and Neck, Ovarian, or Renal Cancer - Full Text View - ClinicalTrials.gov
Classification of tumor types using XGBoost machine learning model: a vector space transformation of genomic alterations |...
Adenocarcinoma2
- At resection of the adnexal mass, histologic diagnosis was high grade serous ovarian adenocarcinoma. (radiopaedia.org)
- Human cell line derived from ovarian serous cyst adenocarcinoma. (riken.jp)
Epithelial3
- A malignant serous cystic epithelial neoplasm arising from the ovary. (nih.gov)
- To establish proper diagnosis and treatment for OC, we analyzed differentially expressed genes (DEGs) for patients with serous epithelial OC, with or without LI, who did or did not survive for 5 years. (ewha.ac.kr)
- The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner. (biomedcentral.com)
Carcinoma6
- Purpose Uterine serous carcinoma is a rare, aggressive variant of endometrial cancer. (nih.gov)
- Trastuzumab is a humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (HER2)/neu, a receptor overexpressed in 30% of uterine serous carcinoma. (nih.gov)
- This multicenter, randomized phase II trial compared carboplatin-paclitaxel with and without trastuzumab in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. (nih.gov)
- These encouraging results deserve further investigation to determine their impact on overall survival in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. (nih.gov)
- The authors retrospectively reviewed demographic, pathologic, and survival data of 290 patients with stage III serous ovarian carcinoma treated with surgery and chemotherapy on GOG Protocol 158, a cooperative multicenter group trial. (nih.gov)
- Women with high-grade versus low-grade serous carcinoma of the ovary are 2 distinct patient populations. (nih.gov)
Mucinous4
- Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and rare solid serous adenomas). (hindawi.com)
- Pancreatic cystic tumors fall into the serous or mucinous category. (hindawi.com)
- We wondered whether the worse prognosis associated with mucinous histology is also valid when age, tumor grade, substage of disease, and extent of RD are matched with serous histology in women with stage III EOC who have undergone primary CRS followed by standard intravenous paclitaxel plus carboplatin chemotherapy. (biomedcentral.com)
- women with mixed histologies including mucinous tumors combined with endometrioid, serous, clear-cell, and/or other histologic types were excluded. (biomedcentral.com)
Cystadenoma3
- Rare occurrence in the pancreas has been reported, although this is not typical, with the majority of microcystic pancreatic masses representing alternate disease processes such as the more benign serous cystadenoma. (wikipedia.org)
- Features on computed tomography raised the possibility of biliary cystadenoma or cystadenocarcinoma. (uwi.edu)
- She underwent a liver resection, and histopathology confirmed a serous biliary cystadenoma. (uwi.edu)
Ovary2
- Most commonly, the primary site of serous cystadenocarcinoma is the ovary. (wikipedia.org)
- Morphologic criteria for the prognosis of serous cystadenocarcinoma of the ovary. (nih.gov)
Tumor3
- Serous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. (wikipedia.org)
- Conclusion: The DEGs identified in this study could be used to elucidate the mechanism of tumor progression and to guide the prognosis and treatment of patients with serous OC but without LI. (ewha.ac.kr)
- Each case was matched to two women with stage III serous EOC in terms of age, tumor grade, substage of disease, and extent of residual disease. (biomedcentral.com)
Ovarian cancer1
- The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic pathway network. (mcmaster.ca)
Tumors2
- A study was undertaken to use the 2-tier system to reclassify the grade of serous ovarian tumors previously classified using the International Federation of Gynecology and Obstetrics (FIGO) 3-tier system and determine the progression-free survival (PFS) and overall survival (OS) of patients treated on Gynecologic Oncology Group (GOG) Protocol 158. (nih.gov)
- Patients with MOC seem to be 2.3 times more likely to die of their tumors when compared to women with serous EOC. (biomedcentral.com)
Stage III serous1
- The objective of this retrospective, multicenter study was to compare prognostic factors of women with stage III MOC to those of women with stage III serous EOC treated in the same fashion. (biomedcentral.com)
Carboplatin1
- Inferences of carboplatin response-related signature by integrating multiomics data in ovarian serous cystadenocarcinoma. (nih.gov)
Survival2
- Hormone replacement therapy after invasive ovarian serous cystadenocarcinoma treatment: the effect on survival. (nih.gov)
- Social, Genetics and Histopathological Factors Related to Titin (TTN) Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis. (nih.gov)
Endometrial1
- Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas. (beds.ac.uk)
Cancers5
- Serous ovarian most cancers is the most typical and first loss of life kind in ovarian most cancers. (cellgenetherapy.com)
- L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
- Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
- ces cancers ont ete diagnostiques au stade avance d'ou les difficultes dans leur prise en charge chirurgicale. (bvsalud.org)
- En consequence notre objectif a ete d'etudier la place et les caracteres de la chirurgie dans la prise en charge de ces cancers. (bvsalud.org)
Case1
- The interactive module below presents a case of ovarian serous cystadenocarcinoma through pre- and post-operative contrast-enhanced CT as well as a 3D reconstruction. (medscape.com)
Clinical2
Treatment1
- A Network Pharmacology-Based Analysis of Multi-Target, Multi-Pathway, Multi-Compound Treatment for Ovarian Serous Cystadenocarcinoma. (nih.gov)
Literature1
- Firstly, this is the largest cystadenocarcinoma reported in the literature. (hindawi.com)
Mucinous cystadenocarcinoma1
- Although CA125 expressed a remarkable diagnostic efficiency with serous cystadenocarcinoma, it was less efficient with mucinous cystadenocarcinoma. (nih.gov)
Adenocarcinoma2
Papillary2
Carcinomas4
- Targetable Immune Regulatory Molecule Expression in High-Grade Serous Ovarian Carcinomas in African American Women: A Study of PD-L1 and IDO in 112 Cases From the African American Cancer Epidemiology Study (AACES). (musc.edu)
- 19. [Expression and clinicopathologic significance of CD44v6/CD24 in ovarian serous carcinomas]. (nih.gov)
- Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas. (omeka.net)
- In the present study, the expression of beta-catenin and cyclinD1 was examined in 60 ovarian serous carcinomas patients with immunohistochemical staining. (omeka.net)
Recurrent1
- 4. Ultrasound-Guided Laparoscopic Ovarian Wedge Resection in Recurrent Serous Borderline Ovarian Tumours. (nih.gov)
Descriptor1
- Cystadenocarcinoma, Serous" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Primary1
- 16. Primary retroperitoneal serous cystadenocarcinoma of 'ovarian-type': US and CT findings. (nih.gov)
Type1
- Also, histological localization of TAG-72 in the microvilli and apical cytoplasmic membrane was demonstrated by electron microscopy using MAb B72.3 and samples of seromucinous cystadenocarcinoma (mixed type). (nih.gov)
Major1
- This graph shows the total number of publications written about "Cystadenocarcinoma, Serous" by people in this website by year, and whether "Cystadenocarcinoma, Serous" was a major or minor topic of these publications. (musc.edu)
Grade3
- 1. Management of low-grade serous ovarian neoplasm in the setting of fertility preservation. (nih.gov)
- 18. High-Grade Serous Ovarian Cancer: Use of Machine Learning to Predict Abdominopelvic Recurrence on CT on the Basis of Serial Cancer Antigen 125 Levels. (nih.gov)
- Is Trametinib a New Standard for Low-Grade Serous Ovarian Cancer? (medscape.com)