Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Ferrets: Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Felis: Genus in the family FELIDAE comprised of small felines including the domestic cat, Felis catus (CATS) and its ancestor the wild cat, Felis silvestris.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)HSP70 Heat-Shock Proteins: A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures.Heat-Shock Proteins: Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.HSP27 Heat-Shock Proteins: A subfamily of small heat-shock proteins that function as molecular chaperones that aid in refolding of non-native proteins. They play a protective role that increases cellular survival during times of stress.alpha-Crystallin B Chain: One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.alpha-Crystallins: A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.HSC70 Heat-Shock Proteins: A constitutively expressed subfamily of the HSP70 heat-shock proteins. They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION.Cholangiopancreatography, Magnetic Resonance: Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Cholangiopancreatography, Endoscopic Retrograde: Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Pancreatic Extracts: Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.Pancrelipase: A preparation of hog pancreatic enzymes standardized for lipase content.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Gingiva: Oral tissue surrounding and attached to TEETH.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Epididymal Secretory Proteins: Proteins secreted by the epididymal epithelium. These proteins are both tissue- and species-specific. They are important molecular agents in the process of sperm maturation.CA-125 Antigen: Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.Hysterectomy: Excision of the uterus.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.Saudi ArabiaAnaplasia: Loss of structural differentiation and useful function of neoplastic cells.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Diet: Regular course of eating and drinking adopted by a person or animal.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Benz(a)Anthracenes: Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Medicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Waiting Lists: Prospective patient listings for appointments or treatments.Individualized Medicine: Therapeutic approach tailoring therapy for genetically defined subgroups of patients.Internal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.Nuclear Medicine: A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.

Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer. (1/83)

Papillary serous endometrial carcinoma is an aggressive tumor characterized by late-stage presentation, i.p. spread, and poor prognosis. It is histologically similar to serous papillary carcinoma of the ovary. Preclinical studies have shown that adenovirus-mediated expression of p53 in ovarian cancer cell lines causes growth inhibition and apoptosis in vitro and in vivo. Such studies provide the rationale for Phase I Adp53 gene therapy clinical trials in ovarian cancer. In the present study, we compared the efficacy of adenoviral vectors containing p53 (Adp53) or p21 (Adp21) in a papillary serous endometrial tumor cell line (SPEC-2) that contains mutated p53. Growth assays revealed that both Adp53 and Adp21 were efficacious in decreasing cell proliferation as assessed by anchorage-dependent and anchorage-independent growth assays. However, as compared with Adp53, the effects of Adp21 tended to be more transient and less marked. Strikingly, Adp21, but not Adp53, induced a G1 arrest in SPEC-2 endometrial adenocarcinoma cells. In contrast, as assessed by induction of hypodiploid peaks, free DNA ends detected by a terminal deoxynucleotidyl transferase-based assay, and annexin V positivity, p53 was more effective than p21 in inducing cell death by apoptosis. Compatible with the more efficient induction of apoptosis, Adp53, but not Adp21, induced a marked increase in expression of the preapoptotic molecule BAX without a concomitant change in expression of the antiapoptotic mediator Bcl-2. The differential effects of Adp53 and Adp21 on cell cycle progression and apoptosis may be related to the reversibility of p21-induced cell cycle arrest and the irreversibility of p53-induced apoptosis. Thus, at least in the papillary serous endometrial carcinoma cell line SPEC-2, Adp53 may be more effective than Adp21 as a gene therapeutic. Nevertheless, these preclinical studies suggest that papillary serous endometrial carcinoma is a potential target for p53- or p21-mediated gene therapy.  (+info)

Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. (2/83)

The differences in immunohistochemical expression of p53, bcl-2, bax, estrogen receptor (ER), and progesterone receptor (PR) were evaluated in 40 endometrioid and 21 papillary serous carcinomas of endometrium and correlated with known predictors of survival, such as grade and stage. Uterine papillary serous adenocarcinomas (UPSA) showed significantly higher p53 expression than did uterine endometrioid adenocarcinomas (UEA) (76.2% versus 35%), whereas both ER and PR were more often positive in endometrioid than in serous tumors (p = .005 and .0005). No significant difference was found in bcl-2 and bax expression between both histologic types. However, there was definite decrease in intensity of bcl-2 in UPSA compared with UEA. In endometrioid carcinoma, p53 overexpression was associated with high-grade and advanced-stage tumors (p = .0006 and .006), whereas ER and PR expression was associated with low-grade and early-stage tumors (p = .0006 and .0001; p = .003 and .0006). Bcl-2 immunopositivity was more common in low-grade, early-stage rather than in high-grade, advanced-stage adenocarcinomas, but the difference was not statistically significant (p = .24 and .07). Bax immunopositivity was associated with well-differentiated (p = .04) and early-stage tumors. Furthermore, a significant inverse relationship between bax and p53 reactivity was defined (p = .05), especially in tumors of endometrioid type. Bax and PR immunoexpression correlated near the limit of statistical significance (p = .08), whereas no relationship was found among bax, bcl-2, and ER immunopositivity. Our results indicate that the differences in immunohistochemical profiles of endometrioid and serous carcinomas support the existence of different molecular pathways of their development. The correlation of immunohistochemical findings with histologic grade and clinical stage could help in predicting biologic behavior and planning treatment in patients who are diagnosed as having these tumors.  (+info)

Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer. (3/83)

INTRODUCTION: Patients with recurrent ovarian cancer were treated with a replication-deficient recombinant adenovirus containing the herpes simplex virus thymidine kinase gene administered intraperitoneally (i.p.) followed by administration of an anti-herpetic prodrug and topotecan. MATERIALS AND METHODS: A total of 10 patients with stage IIIc epithelial ovarian cancer underwent secondary debulking to < or =0.5 cm residual tumor. Patients with normal i.p. flow received i.p. delivery of adenovirus. Two patients each were treated on dose level 1 (2 x 10(10) vector particles (VP)), dose level 2 (2 x 10(11) VP), and dose level 3 (2 x 10(12) VP); four patients were treated on dose level 4 (2 x 10(13) VP). Acyclovir and topotecan were started 24 hours after vector delivery. RESULTS: No patient treated at any dose level incurred unanticipated toxic effects, and all side effects resolved. The most common adverse event was myelosuppression: grade 3 or 4 thrombocytopenia with grade 2-4 anemia in three patients and grade 3 or 4 neutropenia in eight patients. Three patients developed thrombocytosis and three patients had a mild elevation of serum glutamic pyruvic transaminase/alanine aminotransferase. Temperature elevations that were not associated with detectable infection occurred in two patients. DISCUSSION: I.p. delivery of adenoviral vector with concomitant topotecan chemotherapy was well tolerated without significant lasting toxicities. Side effects were independent of the dose of adenoviral vector.  (+info)

Distinct allelic loss patterns in papillary serous carcinoma of the peritoneum. (4/83)

Tumor and normal tissues from 55 patients with papillary serous carcinoma of the peritoneum (PSCP) were analyzed. Polymerase chain reaction amplification of tandem repeat polymorphism was used to screen for loss of heterozygosity (LOH). We mapped 22 oligonucleotide primers to chromosomes 1p, 3p, 6q, 7q, 9p, 11p, 17p, 17q, and Xq. Germline BRCA1 mutation status of 43 patients was determined previously. High frequencies (> 30%) of LOH in PSCP were observed on 6q, 9p, 17p, 17q, and Xq. Compared with allelic loss of serous epithelial ovarian carcinoma (SEOC), the frequency of LOH was significantly lower in PSCP on 1p, 7q, 11p, 17p, and 17q. Of 43 cases screened for germline BRCA1 mutations, 9 cases were identified with mutations. The frequencies of LOH were not significantly different among the BRCA1-related and BRCA1-unrelated PSCP cases. The high LOH rate identified on 6q, 9p, 17p, 17q, and Xq in PSCP suggests that candidate tumor suppressor genes residing in these regions may be important for the development of the tumor. Compared with allelic loss of SEOC, PSCP exhibits a significantly lower frequency of LOH on chromosomes 1p36, 7q31.3, 11p15.1, 17p13.1, and 17q21. An increase in susceptibility to the acquisition of allelic loss in BRCA1-related PSCP cannot be identified.  (+info)

Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor beta 1 in vitro. (5/83)

OBJECTIVE: To further understand the role of growth regulation of human ovarian cancer cells by transforming growth factor (TGF) beta 1. METHODS: The cell proliferation, cAMP synthesis, gene expression, and induction of programmed cell death (PCD) in human epithelial ovarian cancer cell line HO-8910 cells exposed to TGF beta 1 in vitro were studied. RESULTS: TGF beta 1 inhibited cell growth and DNA synthesis, and induced G0/G1 arrest in cell cycle. It could also trigger PCD in cells. This induction of PCD may occur within G0/G1 phase. Meanwhile, the assay also showed that TGF beta 1 could inhibit the mRNA expression of c-myc, EGFR and TGF beta 1 genes in cells. CONCLUSIONS: TGF beta 1 can not only act as an autocrine to inhibit cell proliferation, but also trigger PCD in HO-8910 cells. These functions may be fulfilled through some specific signal transduction pathways.  (+info)

Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver. (6/83)

Biliary cystadenocarcinoma with oncocytic differentiation was first reported in 1992. This is a report of a second case. The patient (a 71-year-old man) was admitted to our hospital complaining of abdominal fullness. Multicystic lesions were identified in the left hepatic lobe radiologically. The patient died of peritoneal dissemination of carcinoma 20 months later. At autopsy, the tumor of the left hepatic lobe was found to be composed of adjoining multiple cystic lesions and a solid lesion with infiltration of the hepatic hilus and peritoneal dissemination. Histologically, the multicystic lesions were covered by papillary neoplastic epithelial cells with an eosinophilic granular cytoplasm resembling that of oncocytes and a fine fibrovascular core. The cyst wall was fibrous, but there was no mesenchymal stroma. In the solid lesion and infiltrated areas, acidophilic and granular carcinoma cells formed small glandular or solid cord patterns with much mucin secretion (mucinous carcinoma). Immunohistochemically, carcinoma cells of both components were found to contain many mitochondria and showed the phenotypes of hepatocytes and cholangiocytes. Interestingly, the intrahepatic biliary tree also was invaded by carcinoma cells. This may be a case of intraductal oncocytic papillary neoplasm of the left hepatic lobe followed by secondary cystic dilatation of the affected bile duct.  (+info)

Comparison of 'pattern recognition' and logistic regression models for discrimination between benign and malignant pelvic masses: a prospective cross validation. (7/83)

OBJECTIVES: To test prospectively the diagnostic performance of two logistic regression models for calculation of individual risk of malignancy in adnexal tumors (the 'Tailor model' and the 'Timmerman model'), and to compare them to that of 'pattern recognition' (subjective evaluation of the gray-scale ultrasound image and color Doppler ultrasound examination). DESIGN: Consecutive women with a pelvic mass judged clinically to be of adnexal origin underwent preoperative ultrasound examination including color and spectral Doppler examination. The same examination techniques and definitions as those used in the studies in which the logistic regression models had been created were used. The Tailor model was tested in 133 women (35 of whom hada malignancy) and the Timmerman model in 82 women (29 of whom had a malignancy). A subset of 79 women (28 of whom had a malignancy) was used to compare the performance of the Tailor model and the Timmerman model by calculating and comparing the areas under the receiver operating characteristics curves of the two models. Sensitivity and specificity with regard to malignancy were calculated for all three methods. RESULTS: Pattern recognition performed better than the two logistic regression models (sensitivity around 85%, specificity around 90%). Using a risk of malignancy of > 50% to indicate malignancy (as suggested in the original publications), the sensitivity of the Tailor model was 69% and the specificity 88% (n = 133). The corresponding values for the Timmerman model were 62% and 79% (n = 82). The receiver operating characteristics curves showed the two logistic regression models to have similar diagnostic properties (area under the curve, 0.87 vs. 0.84; P = 0.25; n = 79). The diagnostic performance of the mathematical models was much poorer in this study than in those in which the models had been created. CONCLUSION: The poor diagnostic performance of the mathematical models can probably be explained by subtle differences in definitions and examination technique and by differences between the original tumor populations and the study population. For mathematical models to be generally useful, they probably need to be created on the basis of a very large number of tumors, and the variables in the model must be unequivocally defined and the examination technique meticulously standardized.  (+info)

WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas. (8/83)

WT1 diffusely stains most ovarian serous carcinomas; reactivity of uterine papillary serous carcinomas has not been evaluated. We studied WT1 expression in 13 International Federation of Gynecology and Obstetrics stage 1 and 5 stage 3 or 4 uterine papillary serous carcinomas without ovarian metastases and compared their reactivity with the WT1 staining of 30 ovarian serous carcinomas. WT1 reactivity was evaluated with the C19 and 6F-H2 antibody clones. All 18 uterine papillary serous carcinomas were nonreactive for WT1. The nonovarian metastases of the 5 high-stage uterine papillary serous carcinomas also were nonreactive for WT1. In contrast, 29 (97%) of 30 ovarian serous carcinomas were reactive for WT1. WT1 reactivity in an unknown primary serous carcinoma would suggest it is from a nonuterine site. The mechanisms underlying these findings are unknown. They raise the possibility of genetic differences between the 2 morphologically similar neoplasms.  (+info)

*Papillary serous cystadenocarcinoma

Papillary serous cystadenoma Papillary serous cystadenocarcinoma of the ovary images: [1] Kosary, Carol L. (2007). "Chapter 16 ... Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ... Papillary serous cystadenocarcinomas are the most common form of malignant ovarian cancer making up 26 percent of ovarian ... Papillary serous cystadenocarcinomas may exhibit psammoma bodies upon histopathology. ...

*Cystadenocarcinoma

Papillary serous cystadenocarcinoma "Female Genital Pathology". Retrieved 2009-03-23. King JC, Ng TT, White SC, Cortina G, ... Cystadenocarcinoma is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which ... Reber HA, Hines OJ (October 2009). "Pancreatic serous cystadenocarcinoma: a case report and review of the literature". J ...

*Fibroblast growth factor receptor 1

... of ovarian Papillary serous cystadenocarcinoma (almost all amplifications); ~5% of colorectal cancers (~60 amplifications, 40% ...

*Psammoma body

Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ... Papillary thyroid carcinoma Papillary renal cell carcinoma Micropapillary subtype of lung adenocarcinoma Ovarian papillary ... serous cystadenoma and cystadenocarcinoma Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%) Meningiomas, in the ... The term is derived from the Greek word ψάμμος (psámmos), meaning "sand". Psammoma bodies are associated with the papillary ( ...

*List of MeSH codes (C04)

... cystadenocarcinoma, mucinous MeSH C04.557.470.200.025.480.230 --- cystadenocarcinoma, papillary MeSH C04.557.470.200.025.480. ... cystadenocarcinoma, mucinous MeSH C04.557.470.590.480.230 --- cystadenocarcinoma, papillary MeSH C04.557.470.590.480.240 --- ... papillary MeSH C04.557.470.200.025.085.225 --- carcinoma, papillary, follicular MeSH C04.557.470.200.025.095 --- adenocarcinoma ... papillary MeSH C04.557.470.200.400 --- carcinoma, squamous cell MeSH C04.557.470.200.400.130 --- bowen's disease MeSH C04.557. ...

*Cystadenoma

When malignant, it is called cystadenocarcinoma. When not otherwise specified, the ICD-O coding is 8440/0. However, the ... following classifications also exist: serous cystadenoma (8441-8442) papillary cystadenoma (8450-8451, 8561) mucinous ... Picture of serous cystadenoma Serous cystadenoma of pancreas at eMedicine Biliary cystadenoma/cystadenocarcinoma at eMedicine ...

*Pancreatectomy

Cystadenocarcinoma Islet cell tumors (neuroendocrine tumors) Papillary cystic neoplasms Lymphoma Acinar cell tumors Severe ...

*International Classification of Diseases for Oncology

M8460/0 Papillary serous cystadenoma, NOS (C56.9) M8460/3 Papillary serous cystadenocarcinoma (C56.9) Papillary serous ... NOS M8471/3 papillary mucinous cystadenocarcinoma (C56.9) Papillary pseudomucinous cystadenocarcinoma M8472/1 Mucinous cystic ... NOS Intraductal papillary carcinoma, NOS Ductal carcinoma in situ, papillary DCIS, papillary M8503/3 Intraductal papillary ... M8450/3 Papillary cystadenocarcinoma, NOS (C56.9) Papillocystic adenocarcinoma M8451/1 Papillary cystadenoma, borderline ...

*Cystic lesions of the pancreas

Pancreatic intraductal papillary mucinous tumors (most common diagnosis - 52.6%) Pancreatic serous cystic tumors (20.6%) ... Pancreatic mucinous cystadenoma Pancreatic mucinous cystadenocarcinoma Parra-Herran, C. E.; Garcia, M. T.; Herrera, L; Bejarano ... Pancreatic serous cystadenoma Pancreatic serous cystadenocarcinoma Pancreatic mucinous cystic tumors (13.4%) ...

*Testicular cancer

... of the paratesticular structures Adenomatoid tumor Malignant and Benign Mesothelioma Adenocarcinoma of the epididymis Papillary ... borderline malignancy Serous carcinoma Well differentiated endometrioid tumor Mucinous cystadenoma Mucinous cystadenocarcinoma ...

*Serous tumour

On gross examination, the serous tumor may present as either a cystic lesion in which the papillary epithelium is contained ... Sixty percent are benign (cystadenoma), 10% are borderline and 30% are malignant (cystadenocarcinoma). Benign serous tumours ... In borderline lesions, the cyst or surface is lined by papillary structures, which are often very complex. Surgery is usually ... They are lined by a complex papillary pattern with presence of nuclear anaplasia. Serous carcinomas often have bulky peritoneal ...

*Pancreatic mucinous cystic neoplasm

These are designated either "mucinous cystadenocarcinoma" or "mucinous cystic neoplasm with an associated invasive carcinoma." ... Solid pseudopapillary neoplasm Pancreatic serous cystadenoma Intraductal papillary mucinous neoplasm Theruvath TP, Morgan KA, ...

*International Cancer Genome Consortium

... kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer ( ... ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, adrenocortical carcinoma, Diffuse Large B-cell lymphoma, ... Serous cystadenocarcinoma Canada: Pancreatic Cancer - Ductal adenocarcinoma and Prostate Cancer - Adenocarcinoma China: Gastric ...

*The Cancer Genome Atlas

Two tumor types were explored during the pilot phase, Glioblastoma Multiforma (GBM) and Cystadenocarcinoma of the Ovary. The ... TCGA Targeted Tumors: lung squamous cell carcinoma, kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal ... "Integrated Genomic Characterization of Papillary Thyroid Carcinoma". Cell. 159 (3): 676-690. doi:10.1016/j.cell.2014.09.050. ... ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, adrenocortical carcinoma, Diffuse Large B-cell lymphoma, ...

*Surface epithelial-stromal tumor

75% are benign or of borderline malignancy, and 25% are malignant The malignant form of this tumor, serous cystadenocarcinoma, ... including both papillary structures and any necrotic tissue present. lined by tall, columnar, ciliated epithelial cells filled ... the presence of papillary processes, and the location of the epithelial elements. Microscopic pathological features determine ...

*Pancreatic serous cystadenoma

In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and ... "serous cystadenocarcinoma". Serous cystic neoplasms can come to clinical attention in a variety of ways. The most common ...

*Liver cancer

Less common types include mucinous cystic neoplasm and intraductal papillary biliary neoplasm. The diagnosis may be supported ... Cancer of the bile duct (cholangiocarcinoma and cholangiocellular cystadenocarcinoma) account for approximately 6% of primary ...

*Ovarian cancer

It includes serous tumour, endometrioid tumor, and mucinous cystadenocarcinoma. Less common tumors are malignant Brenner tumor ... with gland-like spaces and papillary structures. Polyembryomas, the most immature form of teratoma and very rare ovarian tumors ... Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... and they typically have papillary features, central vessels, and/or irregular internal septations. However, SCST has no ...

*Birt-Hogg-Dubé syndrome

... hereditary papillary renal cancer (papillary renal cell carcinoma), and hereditary leiomyomatosis and renal cell cancer ... mutifocal renal cystadenocarcinoma) and skin tumors (nodular dermatofibrosis). They had a similar pattern of tumorigenesis to ... and papillary renal cell carcinoma. People over 40 years old and men are more likely to develop kidney tumors, which are ... it is associated with clear cell renal cell carcinoma and papillary renal cell carcinoma. If it develops in someone with BHD, ...
Uterine papillary serous carcinoma (UPSC) is an uncommon, but aggressive variant of endometrial carcinoma that has a high recurrence rate and poor response to therapy. It has a propensity to metastasize throughout the abdomen, similar to serous carcinoma of the ovary. In fact, many patients with disease apparently confined to the uterus have microscopic intra-abdominal spread at the time of diagnosis. Recurrences are common both in the pelvis as well as in the upper abdomen.. After staging and debulking of gross disease, adjuvant radiation therapy is recommended to treat patients with endometrial carcinoma at high risk for recurrent disease. High-risk features include histologic cell type, grade, depth of myometrial invasion, cervical extension, lymph-vascular invasion, adnexal involvement, intraperitoneal spread, positive peritoneal cytology, and positive lymph nodes. Pelvic radiation can limit local recurrences to less than 6.5%. However, approximately 25-30% of patients with high-risk ...
Objectives: To determine recurrence patterns and survival outcomes of stage II uterine papillary serous carcinoma (UPSC) patients treated by various modalities with an emphasis on carboplatin/paclitaxel-based chemotherapy (CT) +/- radiotherapy (RT). Methods: A retrospective, multi-institution study of women with stage II UPSC diagnosed from 1992 to 2006 was performed. All patients underwent comprehensive surgical staging. Treatment included observation (OBS), RT (vaginal brachytherapy, whole pelvic and/or whole abdominal therapy), or ≥ 3 cycles carboplatin/paclitaxel alone or with RT. Recurrence and survival outcomes were determined. Results: We identified 55 subjects: 10 treated with OBS, 26 with RT alone and 19 with CT +/- RT. After a median follow-up of 33 mos (range, 10-119), 20 recurrences (36%) were observed. There was an overall difference in recurrence based upon treatment (p = .013). Specifically, all CT +/- RT treated patients had a lower risk of recurrence (11%) compared to patients ...
Uterine papillary serous carcinoma: A rare type of endometrial carcinoma with worse outcomes-IJOGR-Print ISSN No:-2394-2746 Online ISSN No:-2394-2754Article DOI No:-10.18231/2394-2754.2019.0022,Indian Journal of Obstetrics and Gynecology Research-IP Innovative Publication Pvt Limited, Medical Journals Publication, Op
A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia....
Researchers used Caris Molecular Intelligence® to evaluate 240 uterine papillary serous carcinoma (UPSC) and 1,587 epithelial ovarian serous carcinoma (EOC-S) samples, and to compare the molecular profiles of the two cancer subtypes.. The tumor suppressor gene TP53 was the most commonly mutated gene in both UPSC and EOC-S (76% vs. 69%) samples. UPSCs were more likely than EOC-S samples to harbor mutations in the oncogenes PIK3CA (29% vs. 2%), FBXW7 (12% vs. 1%), KRAS (9% vs. 5%), the tumor suppressor protein PTEN (7% vs. 1%), and CTNNB1 (2% vs. 0%).. "Whereas uterine papillary serous carcinoma appears to have a distinct mutation profile, indicating higher activity of the PI3K/PTEN/mTOR pathway, we saw no differences between uterine papillary and ovarian serous carcinomas in alteration of the homologous recombination pathway," remarked principal investigator Robert DeBernardo, MD, Gynecologic Oncologist and Director of Minimally Invasive Surgery at the Cleveland Clinic Ob/Gyn & Womens Health ...
I guess my hamster days steroid high is over, because I slept 10 hours last night and woke up with something similar to what Marge described, a sort of fogginess. Its not bad, but I feel like if I crawled back under the covers, I just might go back to sleep again. (Not doing that!) I agree that we are all doing so much better than any of us probably dared to hope. There are surely some rough days ahead, but one day at a time is the way to go, and making the most of each good day. I wonder if we will continue to come here after our treatments are over??? I see 20-year survivors posting here on other boards, wanting to be here as a resource to those that come after them with their same cancers. Id like to think well be like that, with this thread always flagged for email alerts, ready to jump back in when those newly diagnosed with UPSC using the SEARCH box, find this thread. Even if any of us decide to close the door on this chapter of our life and never look back, think how great it will ...
Zanotti The Cleveland Clinic Foundation Uterine papillary serous carcinoma (UPSC) is undoubtedly an intense malignancy which has a histologic visual appeal and pattern of spread that resembles that of papillary serous adenocarcinoma with the ovary. The current conventional therapy for Superior ovarian most cancers, cisplatin or carboplatin moreover paclitaxel, results in high aim response premiums for that tumor. This program has Up to now not been evaluated in i thought about this UPSC. Approaches: 20-four sufferers with UPSC treated with platinum-based mostly chemotherapy and paclitaxel were being retrospectively evaluated. Eighteen clients acquired these agents within the adjuvant placing (n = 9) or for sickness persistent just after initial surgical management (n = nine). Eleven patients gained one or more classes of this drug blend for recurrent ailment, 5 of whom experienced prior publicity while in the First setting ...
Ueda SM, Yap, KL, Davidson, B et al. Expression of fatty acid synthase depends on NAC1 and is associated with recurrent ovarian serous carcinomas. J Oncology 2010;2010:285191.. Krill LS, Ueda SM, Gerardi M, Bristow RE. Analysis of postoperative complications associated with the use of anti-adhesion sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier after cytoreductive surgery for ovarian, fallopian tube and peritoneal cancers. Article in press for Gynecol Oncol. 2011 Feb; 120(2):220-3. Skaznik-Wikiel ME, Ueda SM, Frasure HE, Rose PG, Fleury A, Grumbine FC, Nickles-Fader A. Abnormal cervical cytology in the diagnosis of uterine papillary serous carcinoma: earlier detection of a poor prognostic cancer subtype? Acta Cytol 2001;55(3):255-60.. Bristow RE, Ueda S, Gerardi MA, Ajiboye OB, Ibeanu OA. Analysis of racial disparities in stage IIIC epithelial ovarian cancer care and outcomes in a tertiary gynecologic oncology referral center. Gynecol Oncol 2011;122(2):319-23.. Giuntoli RL, Gerardi ...
PRIMARY OBJECTIVES:. I. To determine if treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for 4 cycles (experimental arm) reduces the rate of recurrence or death (i.e., increases recurrence-free survival) when compared to chemotherapy consisting of carboplatin and paclitaxel for 6 cycles (control arm) in patients with stages III-IVA endometrial carcinoma (, 2 cm residual disease) or patients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage I or II serous (uterine papillary serous carcinoma [UPSC]) or clear cell endometrial carcinoma and positive cytology.. SECONDARY OBJECTIVES:. I. To determine if treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for 4 cycles (experimental arm) reduces the rate of death (i.e., increases survival) when compared to chemotherapy consisting of carboplatin and paclitaxel for 6 cycles (control arm) in patients with stages III-IVA endometrial carcinoma (, ...
Decreased Expression of 14-3-3,i,σ,/i, Is Predictive of Poor Prognosis for Patients with Human Uterine Papillary Serous Carcinoma (2013 ...
Pancreatic cancer remains a leading cause of death despite its relatively low incidence. As in many other solid tumors, angiogenesis is critical to the growth and metastasis of this cancer. Through serial in vivo passages in mice, we have developed a highly aggressive variant of human pancreatic cancer cell line XPA-1 which shows more rapid primary tumor growth, faster time to metastasis, and more rapid lethality than the parental cell line. The high-metastatic variant developed a much denser tumor vasculature early during growth within the pancreas. Interestingly, examination of the in vitro growth of this aggressive variant yielded no significant difference from the parental cell line. Real-time PCR evaluation of genes involved in angiogenesis revealed a 24-fold increase in Thrombospondin-1 expression in cells derived from the high-metastatic variant when compared with the parental cell line. These findings provide direct evidence that elevated capability for angiogenesis, mediated by specific ...
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Patricia, Ill try to answer the best I can. According to the NCCN Guidelines (which my GYN/ONC group uses), after surgical debulking adjuvant treatment is decided by the patients STAGE. Chemo is a primary treatment for UPSC - papillary serous carcinoma. I didnt question whether to have this or not. EVERYTHING has side effects and I guess we just weigh the pros and cons. My head spins just reading the inserts for prescriptions. I also had fatigue and some neurapathy. I still have some in my toes after 5 months but it is getting better with time.. Radiation is another adjuvant treatment and there are side effects with this. I have stage 3a UPSC and my doctor in so many words thinks the benefits do not outweigh the risks FOR ME. He thinks that I have very good odds NOT to have a recurrence and if I do have one in the vaginal cuff he said he has a 90% cure rate for this. He is very well respected in the field so I am going with his thinking. I think we all need to make these decisions with the ...
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of the uterus, adenexae, onsectonomy and appendectomy for papillary serous carcinoma of the ovary . After 6 chemotherapy cycles tumor recurrence .... ...
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TY - JOUR. T1 - p53 Overexpression and bcl-2 persistence in endometrial carcinoma. T2 - Comparison of papillary serous and endometrioid subtypes. AU - Zheng, Wenxin -. AU - Cao, Peiqin. AU - Zheng, Mei. AU - Kramer, Elmer E.. AU - Godwin, Thomas A.. PY - 1996/5. Y1 - 1996/5. N2 - Forty-two cases, including 21 uterine papillary serous carcinomas (UPSC) and 21 age-, nuclear-grade-, and clinical-stage-matched uterine endometrioid carcinomas (UEC), were studied immunohistochemically for p53 and bcl-2 in archival paraffin-embedded tissue. Compared to UEC (28.6% positive), UPSC (71.4% positive) had a significantly higher frequency of p53 overexpression (P = 0.005); furthermore, in a clinical-stage-matched fashion, a higher frequency of p53 overexpression was found in early-stage cases (P = 0.032), but not in late-stage cases. In a nuclear-grade-matched comparison, no statistical difference in p53 overexpression was identified between the two subtypes, although UPSC had stronger p53 immunoreactivity ...
Serous adenocarcinoma is a type of epithelial ovarian cancer, which is the most common among ovarian cancers. Ovarian cancers account for 6 percent of all cancers among women according to the American Cancer Society. The five-year survival rate in women with advanced ovarian cancer is 15 to 20 percent, but if the disease is found at an early stage, survival approaches 90 percent [16]. Women with a personal/family history of ovarian or other cancers are at the highest risk of having ovarian serous carcinoma, especially if their mother or sister had ovarian cancer. Other risk factors include: increased age, use of high-dose estrogens without progesterone for a long period, uninterrupted ovulation due to infertility, no pregnancies, no use of birth control, and defects in the BRCA1 or BRCA2 genes. Unfortunately, in most women ovarian serous carcinoma is not diagnosed until the disease is advanced, and has spread into the abdomen or beyond due to non-clear physical symptoms. Therefore, early ...
The TP53 gene mutation frequency in ovarian serous carcinomas has been reported to range between 50% and 80%. A research team working at the The Sidney Kimmel Comprehensive Cancer Center of The Johns Hopkins Medical Institutions (Johns Hopkins) made several important findings regarding TP53 gene mutations with respect to high grade ovarian serous carcinoma, as reported in the International Journal of Gynecological Cancer. Ovarian serous carcinoma is the most common tumor subtype within the epithelial ovarian cancer histological classification.. According to the Johns Hopkins research team, a stringent analysis of the TP53 gene using purified epithelial tumor samples has not been performed to accurately assess the TP53 gene mutation frequency and its correlation to tumor histologic grade. The research team assessed the TP53 gene mutational profile in a relatively large series of high-grade (53 primary tumors and 18 recurrent tumors) and 13 low-grade ovarian serous tumors. All samples were ...
Papillary Adenocarcinoma is a type of sinonasal cancer that is found in the wood working industry due to the exposure to of wood dust.
4. Candidates are not permitted to use calculators for answering objective type papers.. Note: Compensatory time of twenty minutes per hour shall be permitted for the candidates with locomotors disability and cerebral palsy where dominant (Writing) extremity is affected to the extent of slowing the performance of function (minimum of 40% impairment) in the Combined Medical Services Examination, 2016.. Part II: Personality Test: Candidates who qualify in the Computer based Examination will be called for Interview/ Personality Test to be conducted by the Union Public Service Commission (UPSC). The Interview/ Personality Test will cary 100 marks ...
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Rare and highly aggressive, a rhabdoid tumour is generally found in the cerebellum and occurs in children aged two to 13.. Initially considered an aggressive variant of Wilms tumour of the kidney, its now believed to be a subset of medulloblastomas.. ...
Combined Defence Services Examination(CDSE) is conducted by Union public Service commission (UPSC) . UPSC conducts two exam yearly. The CDS I exam will be held in the month of February and the CDS II will be held in AUG. CDSE exam consist of three parts namely General knowledge, English and Elementary mathematics. The questions are all objective type question and each paper will be give 2 hour for the exam. There is negative marking in this exam. Through this exam on can join the three armed forces (Army, Navy and Air-force). Two entry is possible with CDSE - IMA and OTA. For IMA one has write all the 3 papers , whereas for OTA only GK and English paper is enough ...
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Reading Time: 2 mins The government is thinking of a plan to sell LPG blended with methanol, which could facilitate reduction in its cooking gas subsidy by 1/3rd of its current prices. The plan is to manufacture methanol from abundantly available low-quality coal and other bio resources, and also produce it synthetically. The project would be implemented by the NITI Aayog. ...
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The origin of HCO is unknown. The majority of patients are postmenopausal females; however, it may also affect females of reproductive age and it has been identified in patients between the ages of 35 and 78 years. The most common signs and symptoms of HCO are abdominal distension, abdominal pain and pelvic mass. All patients reported in this study presented with an elevated serum AFP (16/16) level and the majority of patients had an elevated CA-125 (12/15) level. HCO cases may occur alone or in combination with other types of ovarian tumor, including serous papillary carcinomas (6), mucinous/serous/endometrioid denocarcinomas (11) or Sertoli-type sex cord-stromal tumors (17). The tumor differentiates poorly and progresses rapidly. When diag-nosed, the FIGO stage is usually advanced. Of the reported cases, 14 cases were stage III, three were stage II B, six were stage I and the remaining two were of unknown stage. Patients usually succumb to the disease within 2 years (1).. The tumor may appear ...
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Bouchalova, P., Nenutil, R., Muller, P., Hrstka, R., Appleyard, M. V., Murray, K., Jordan, L. B., Purdie, C. A., Quinlan, P., Thompson, A. M., Vojtesek, B. & Coates, P. J. Jul 2014 In : Journal of Pathology. 233, 3, p. 238-246 9 p.. Research output: Contribution to journal › Article ...
Diabetes and Hypertension - The association with obesity accounts for much of the risk but studies have found independent effects as well.. Family History - A history of colon, endometrial or ovarian cancer may point to Lynch Syndrome which places women at particularly high risk.. Most women with endometrial cancer are diagnosed at an early stage and have a very good prognosis. The risk factors for more aggressive variants are less clear but they may occur more commonly in black women. Uterine sarcomas occur in the uterine muscle or structural elements rather than the lining of the uterus and though very rare, are associated with a history of pelvic radiation and tamoxifen use.Family History - A history of colon, endometrial or ovarian cancer may point to Lynch Syndrome which places women at particularly high risk.. ...
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The NCI-H441 cell line was derived by A.F. Gazdar, M. Brower and D. Carney and associates in 1982 from the pericardial fluid of a patient with papillary adenocarcinoma of the lung.
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The effective treatment of ovarian serous carcinoma remains a major challenge because of the recurrence of platinum-resistant tumors. The mechanism of platinum-resistance may involve decreased cellular uptake caused by abnormalities of transporters, intracellular cisplatin inactivation (e.g., caused by glutathione), and increased DNA repair (18). However, no available therapy prevents platinum-resistance.. TBX2 is overexpressed by numerous human cancers (7-14). TBX2 may serve as a prognostic factor of breast cancer (7,9), melanoma (8), gastric cancer (10), prostate cancer (11), laryngeal squamous cell carcinoma (12), and non-small cell lung cancer (14). TBX2 is associated with resistance to therapeutic drugs such as cisplatin and doxorubicin (15,16), and TBX2 therefore may serve as a therapeutic target.. One report shows that chromosome 17q12-q24 harbors strong candidates for ovarian tumorigenesis, such as LASP1 (17q12), TGF11 (17q21.32), MUL (17q23.2), TBX2 (17q23.2), AXIN2 (17q24.3), and GRB2 ...
... Cell Signal. 2020 Jan 11;:109539 Authors: El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, Kabil N, Ozpolat B, Calin GA, Salama SA, Abd-Allah AR, Sood AK, Lopez-Berestein G Abstract High-grade serous ovarian carcinoma (HGSOC) is the mos...
Diabetes and Hypertension - The association with obesity accounts for much of the risk but studies have found independent effects as well.. Family History - A history of colon, endometrial or ovarian cancer may point to Lynch Syndrome which places women at particularly high risk.. Most women with endometrial cancer are diagnosed at an early stage and have a very good prognosis. The risk factors for more aggressive variants are less clear but they may occur more commonly in black women. Uterine sarcomas occur in the uterine muscle or structural elements rather than the lining of the uterus and though very rare, are associated with a history of pelvic radiation and tamoxifen use.Family History - A history of colon, endometrial or ovarian cancer may point to Lynch Syndrome which places women at particularly high risk.. ...
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Low-grade cribriform cystadenocarcinoma of salivary glands Definition : Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described (...)
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120. A 32 year-old male patient presents in casualty department with history of RTA one hour back; on examination is found that BP Js 90/50 mm Hg, pulse rate 110 beats per minute, with fracture left lower ribs, and generalized distension of abdomen with guarding and rigidity. He also complained of pain on the tip of the left shoulder. As a casualty Medical Officer you must exclude which one of the following clinical conditions on the primary basis ...
However, many initiatives have been taken in the recent years like the new Strategic purchase model with private industry involvement,Defence procurement focus on Indigenous design ,development & manufacturing "IDDM",Make in India & Skill India mission .All these need to be implemented effectively.. Similarly recent reports of CAG on Akaash missiles and defence procurement needs to be taken seriously.. India needs to emulate the French model of integrated procurement and acquisition structure.. ...
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TY - JOUR. T1 - Is invasive micropapillary serous carcinoma a low-grade carcinoma?. AU - Ohishi, Yoshihiro. AU - Imamura, Hiroko. AU - Aman, Murasaki. AU - Shida, Kaai. AU - Kaku, Tsunehisa. AU - Kato, Kiyoko. AU - Oda, Yoshinao. PY - 2016/1/1. Y1 - 2016/1/1. N2 - "Invasive micropapillary serous carcinoma" has been proposed as a synonym for low-grade serous carcinoma by some expert pathologists. In contrast, Singer and colleagues reported that some serous carcinomas with conspicuous invasive micropapillary pattern (SC-IMPs) can show high-grade nuclear atypia. However, the molecular features of such tumors have not been well documented. The aim of this study was to demonstrate and emphasize the fact that high-grade serous carcinoma confirmed by immunohistochemistry and molecular analysis can show conspicuous invasive micropapillary pattern. We selected 24 "SC-IMPs" and investigated: (1) their morphologic features; (2) the immunostaining pattern of p53 protein; and (3) KRAS/BRAF/TP53 gene ...
Serous borderline tumor (SBT) of the micropapillary type (SBT-MP) became one of the major pathological SBT diagnoses in addition to typical SBT, and was also defined as
Seminar, 2017-09-18, UPSC Cutting-Edge Seminar: Mechanical Signaling and Pattern Formation in the Arabidopsis Shoot Apical Meristem, Elliot Meyerowitz, Division of Biology and Biological Engineering, Howard Hughes Medical Institute and California Institute of Technology, Pasadena, USA
This 4 arm study will assess the optimal starting dose of Mircera in the treatment of anemia in patients with non-small cell lung cancer receiving first
High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed ...
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Lok Satta Party national President Dr. Jayaprakash Narayan will be the special guest of honor at a function being held at Pune on Tuesday, July 30 to felicitate successful candidates in the UPSC Civil Services examination - 2012.
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Pancreatic cystadenocarcinoma is an extremely rare neoplasm in pregnancy. To our knowledge, there have been 2 published cases of pancreatic mucinous cystadenocarcinoma (PMC) during pregnancy in the literature; one of which was reported to have ruptur
Semantic Scholar extracted view of EDUCATION AND IMAGING. Hepatobiliary and Pancreatic: Long-term survival of serous cystadenocarcinoma of the pancreas with synchronous liver metastases after aggressive surgical resection. by Hayato Sasaki et al.
A malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat). Can appear in uterine, ovarian, pancreatic locations. Also known as Mixed Mullerian Tumor.
Cystadenocarcinoma is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. Similar tumor histology has also been reported in the pancreas, although it is a considerably rarer entity. It is the most common malignant ovarian tumor.[citation needed] Contains complex multi-loculated cyst but with exuberant solid areas in places. It usually presents with omental metastases which cause ascites. Papillary serous cystadenocarcinoma "Female Genital Pathology". Retrieved 2009-03-23. King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ (October 2009). "Pancreatic serous cystadenocarcinoma: a case report and review of the literature". J Gastrointest Surg. 13 (10): 1864-8. ...
Mucinous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ovary. Tumors are normally multilocular with various smooth, thin walled cysts. Within the cysts is found a haemorrhagic or cellular debris. Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case report and review of the literature". Arch. Pathol. Lab. Med. 127 (8): 1031-3. doi:10.1043/1543-2165(2003) ...
Looking for online definition of endometrioid carcinoma in the Medical Dictionary? endometrioid carcinoma explanation free. What is endometrioid carcinoma? Meaning of endometrioid carcinoma medical term. What does endometrioid carcinoma mean?
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...

papillary cystadenocarcinomapapillary cystadenocarcinoma

Familial risks of over 4.0 were found for serous papillary cystadenocarcinoma of the ovary, papillary thyroid cancer and low- ... Cystadenocarcinoma (papillary cystadenocarcinoma) of the salivary gland is a rare malignant neoplasm... ... Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. A Harimaya. Department of Otolaryngology, Sapporo ... Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. A Harimaya. Department of Otolaryngology, Sapporo ...
more infohttps://www.labome.org/topics/diseases/neoplasms/neoplasms/glandular/and/cystadenocarcinoma/papillary-cystadenocarcinoma-5739.html

Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferretMetastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret

... papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, ... Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret. Journal of Wildlife Diseases By:. J.W. ... Metastatic, papillary cystadenocarcinoma of the mammary gland in a black-footed ferret. Series title:. Journal of Wildlife ... A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes ...
more infohttps://pubs.er.usgs.gov/publication/5221624

Papillary serous cystadenocarcinoma - WikipediaPapillary serous cystadenocarcinoma - Wikipedia

Papillary serous cystadenoma Papillary serous cystadenocarcinoma of the ovary images: [1] Kosary, Carol L. (2007). "Chapter 16 ... Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer ... Papillary serous cystadenocarcinomas are the most common form of malignant ovarian cancer making up 26 percent of ovarian ... Papillary serous cystadenocarcinomas may exhibit psammoma bodies upon histopathology. ...
more infohttps://en.wikipedia.org/wiki/Papillary_serous_cystadenocarcinoma

Cytomorphologic features of papillary cystadenocarcinoma of the parotid. | DocphinCytomorphologic features of papillary cystadenocarcinoma of the parotid. | Docphin

Cytomorphologic features of papillary cystadenocarcinoma of the parotid. , Diagnostic cytopathology , 6/1/2002 ... Cytomorphologic features of papillary cystadenocarcinoma of the parotid. Kusum Kapila Kusum Verma 6/1/2002 ... Kapila K, Verma K. Cytomorphologic features of papillary cystadenocarcinoma of the parotid. Diagn Cytopathol. 2002;26(6):392-7. ... Papillary cystadenocarcinomas of the parotid are rare but can be accurately diagnosed on FNAC. However, they need to be ...
more infohttps://www.docphin.com/research/article-detail/8694831/PubMedID-12112832/Cytomorphologic-features-of-papillary-cystadenocarcinoma-of-the-parotid

37. Serous papillary cystadenocarcinoma of the ovary - greek.doctor37. Serous papillary cystadenocarcinoma of the ovary - greek.doctor

Serous papillary cystadenocarcinoma of the ovary. Last updated on May 10, 2019 at 16:47 ... This cyst is lined by atypical epithelial cells, and it contains papillary processes. ...
more infohttps://greek.doctor/pathology-2/histopathology-slides/37-serous-papillary-cystadenocarcinoma-of-the-ovary/

Papillary cystadenocarcinoma             | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramPapillary cystadenocarcinoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program

... resources and questions answered by our Genetic and Rare Diseases Information Specialists for Papillary cystadenocarcinoma ... PubMed is a searchable database of medical literature and lists journal articles that discuss Papillary cystadenocarcinoma. ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cluster&id=28695

RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of...RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of...

In the present study, a case of isolated small intestine metastasis of ovarian papillary cystadenocarcinoma was reported. A 7- ... this is the first case of small intestine serousal surface metastasis from ovarian papillary cystadenocarcinoma. ... features coupled with the CK7 immunoreactivity led to a diagnosis of high grade ovarian papillary cystadenocarcinoma. To the ... These findings indicate a tumor of high-grade malignancy with infiterative tumor cells resembling the papillary ovarian tumor ...
more infohttps://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-7-33

HSPA2 Gene - GeneCards | HSP72 Protein | HSP72 AntibodyHSPA2 Gene - GeneCards | HSP72 Protein | HSP72 Antibody

Diseases associated with HSPA2 include Inflammatory Bowel Disease 3 and Papillary Cystadenocarcinoma. Among its related ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=HSPA2

QT Interval Prolongation Study of Eribulin Mesylate (E7389) in Patients With Advanced Solid TumorsQT Interval Prolongation Study of Eribulin Mesylate (E7389) in Patients With Advanced Solid Tumors

Cystadenocarcinoma, Papillary. An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a ... Cystadenocarcinoma, Mucinous. A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. ...
more infohttps://www.bioportfolio.com/resources/trial/65884/QT-Interval-Prolongation-Study-of-Eribulin-Mesylate-E7389-in-Patients-With-Advanced.html

Foundations Flashcards by Rutvi Patel | BrainscapeFoundations Flashcards by Rutvi Patel | Brainscape

Papillary adenocarcinoma of thyroid. - Serous papillary cystadenocarcinoma of ovary. - meningioma. - malignant mesothelioma ...
more infohttps://www.brainscape.com/flashcards/foundations-1666593/packs/3141178

Chronic Pancreatitis - American Family PhysicianChronic Pancreatitis - American Family Physician

Papillary cystadenocarcinoma of ovary. Thoracic radiculopathy. Information from references 2, 4, and 16 through 18. ...
more infohttps://www.aafp.org/afp/2007/1201/p1679.html

ATCC Products by Tissue - Ovary Page 1ATCC Products by Tissue - Ovary Page 1

Ovarian Serous Cystadenocarcinoma, Stage Iii, Grade 2 (1) * Ovarian Teratoma (1) * Papillary Cystadenocarcinoma Of The Ovary (1 ... Grade 3, Stage Iiic, Malignant Papillary Serous Adenocarcino... (1) * Grade 3, Stage Iiic, Primary Malignant Adenocarcinoma; ...
more infohttps://www.atcc.org/Products/Cells_and_Microorganisms/By_Tissue/Ovary.aspx?dsNav=Ro:20,Nrc:id-1000507-dynrank-disabled&hasShowAll=1000507%7C

ATCC Products by Tissue - Ovary Page 2ATCC Products by Tissue - Ovary Page 2

Ovarian Serous Cystadenocarcinoma, Stage Iii, Grade 2 (1) * Ovarian Teratoma (1) * Papillary Cystadenocarcinoma Of The Ovary (1 ... Grade 3, Stage Iiic, Malignant Papillary Serous Adenocarcino... (1) * Grade 3, Stage Iiic, Primary Malignant Adenocarcinoma; ...
more infohttps://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Ovary.aspx?dsNav=Ro:40,Nrc:id-1000507-dynrank-disabled&slp=1&hasShowAll=1000507%7C

USMLE Deck2 Flashcards by nathan hawkey | BrainscapeUSMLE Deck2 Flashcards by nathan hawkey | Brainscape

Papillary adenocarcinoma of thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma ... Tyrosine Kinase (neurotrophic growth factor); MEN IIA and IIB; papillary thyroid carcinoma ...
more infohttps://www.brainscape.com/flashcards/usmle-deck2-692457/packs/1281681

Familial association of specific histologic types of ovarian malignancy with other malignancies - Bermejo - 2004 - Cancer -...Familial association of specific histologic types of ovarian malignancy with other malignancies - Bermejo - 2004 - Cancer -...

... papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and ... risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/cncr.20138/abstract

ScopeMed.org - Deposit for Medical ArticlesScopeMed.org - Deposit for Medical Articles

Papillary cystadeno carcinoma A Very Rare Case Report. Dr.Sherin.A.Khalam, Dr.Ninan Thomas, Dr. Anroop A. The Southeast Asian ... Association of lymphocytic thyroiditis and papillary thyroid carcinoma: a retrospective study done at a tertiary care centre in ...
more infohttp://www.scopemed.org/?term=POOJA%20THOMAS%20AND%20MALLIKA%20KURAT%20JAYAVARMA&sarea=author&b1=Search+ScopeMed

Biliary tract | definition of biliary tract by Medical dictionaryBiliary tract | definition of biliary tract by Medical dictionary

Papillary cystadenocarcinoma of ovary presenting as obstructive jaundice: a rare presentation. Liver function tests are normal ...
more infohttps://medical-dictionary.thefreedictionary.com/biliary+tract

adenocarcinoma endometrial stage iv 2005:2010[pubdate] *count=100 - BioMedLib™ search engineadenocarcinoma endometrial stage iv 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Cystadenocarcinoma, Serous / pathology. Cystadenocarcinoma, ... Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / metabolism. Cystadenocarcinoma, Serous / diagnosis. Cystadenocarcinoma ... Cystadenocarcinoma, Papillary / therapy. Cystadenocarcinoma, Serous / therapy. Female. Humans. Middle Aged. Neoplasm Staging. ... Cystadenocarcinoma, Serous / drug therapy. Cystadenocarcinoma, Serous / secondary. Cystadenocarcinoma, Serous / surgery. ...
more infohttp://www.bmlsearch.com/?kwr=adenocarcinoma+endometrial+stage+iv+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

A rare case of malignant transformation of endometrioma: a case report, European Journal of Plastic Surgery | 10.1007/s00238...A rare case of malignant transformation of endometrioma: a case report, European Journal of Plastic Surgery | 10.1007/s00238...

The histopathologic diagnosis, surprisingly, was metastasis from papillary cystadenocarcinoma. A hysterosalpingo-oophorectomy ... The histopathologic diagnosis, surprisingly, was metastasis from papillary cystadenocarcinoma. A hysterosalpingo-oophorectomy ...
more infohttps://www.deepdyve.com/lp/springer_journal/a-rare-case-of-malignant-transformation-of-endometrioma-a-case-report-eyVBQqwEE0

Cystadenocarcinoma - WikipediaCystadenocarcinoma - Wikipedia

Papillary serous cystadenocarcinoma "Female Genital Pathology". Retrieved 2009-03-23. King JC, Ng TT, White SC, Cortina G, ... Cystadenocarcinoma is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which ... Reber HA, Hines OJ (October 2009). "Pancreatic serous cystadenocarcinoma: a case report and review of the literature". J ...
more infohttps://en.wikipedia.org/wiki/Cystadenocarcinoma

Complete long term remission of residual/recurring ovarian cancer.Complete long term remission of residual/recurring ovarian cancer.

Histology: Multilocular intra-and extracystic Grade I papillary cyst Adenocarcinoma. Pathol. Dept. Mayo-Clinic, Rochester/USA. ...
more infohttp://issels.com/cancer-cases/ovarian-1-resudial-recurring-ovarian-cancer/

Rare Diseases Awareness Ribbons - P | Personalized CauseRare Diseases Awareness Ribbons - P | Personalized Cause

Papillary cystadenocarcinoma. Papillary eccrine adenoma. Papillary renal cell carcinoma. Papilledema. Papillon Lefevre syndrome ...
more infohttps://www.personalizedcause.com/rare-diseases-and-disorders-awareness-ribbons-p

tumor borderline malignancy drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginetumor borderline malignancy drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

Title] Peritoneal implantations of papillary serous ovarian cystadenocarcinoma 13 days after initial laparoscopic treatment for ... Peritoneal implantations of papillary serous ovarian cystadenocarcinoma 13 days after initial laparoscopic treatment for a ... Mixed-epithelial papillary cystadenoma of borderline malignancy of mullerian type (MEBMM) is composed of a mixture of mullerian ... Title] Squamous predominance in mixed-epithelial papillary cystadenomas of borderline malignancy of mullerian type arising in ...
more infohttp://www.bmlsearch.com/?kwr=tumor+borderline+malignancy+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Cancer Biomarkers - Volume 13, issue 6 - Journals - IOS PressCancer Biomarkers - Volume 13, issue 6 - Journals - IOS Press

Objective: To investigate the level of IL-17A in sera of southern Iranian patients with papillary serous cystadenocarcinoma of ... IL-17A is elevated in sera of patients with poorly differentiated ovarian papillary serous cystadenocarcinoma ... Methods: In this study we investigated IL-17A and CA125 levels in sera of 26 patients with ovarian serous cystadenocarcinoma ... Elevation of IL-17A in a high percentage of ovarian serous cystadenocarcinoma and lack of this cytokine in healthy individuals ...
more infohttps://content.iospress.com/journals/cancer-biomarkers/13/6?rows=10

Hallmark Findings  MedicineHallmark Findings Medicine

Papillary adenocarcinoma of the thyroid Serous papillary cystadenocarcinoma of the ovary Meningioma Mesothelioma ...
more infohttp://www.rxpgonline.com/article56.html
  • Immunohistochemical and ultrastructural findings in a rare case of papillary cystadenocarcinoma arising from the left sublingual gland of a 55-year-old Japanese man are reported. (labome.org)
  • The fine-needle aspiration cytology findings in four cases of recently classified cystadenocarcinoma of the parotid gland are reported. (docphin.com)
  • Smear preparations in all four cases were cellular, with numerous papillary projections, single cells, and sheets of cells in varying proportion in a proteinaceous to mucoid background. (docphin.com)