Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Mucocele: A retention cyst of the salivary gland, lacrimal sac, paranasal sinuses, appendix, or gallbladder. (Stedman, 26th ed)Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Pyonephrosis: Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.Mixed Tumor, Mesodermal: A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. It is associated with previous pelvic radiation exposure in 20% of patients. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1702)Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Biliary Tract Neoplasms: Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.Cystadenoma, Papillary: A benign neoplasm of the ovary.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Barium Sulfate: A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.Pseudomyxoma Peritonei: A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Retroperitoneal NeoplasmsPancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Hydroxy Acids: Organic compounds containing both the hydroxyl and carboxyl radicals.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Pyonephrosis: Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Abdomen, Acute: A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.Fallopian Tube Neoplasms: Benign or malignant neoplasms of the FALLOPIAN TUBES. They are uncommon. If they develop, they may be located in the wall or within the lumen as a growth attached to the wall by a stalk.Second-Look Surgery: A followup operation to examine the outcome of the previous surgery and other treatments, such as chemotherapy or radiation therapy.Peritoneal Neoplasms: Tumors or cancer of the PERITONEUM.Appendix: A worm-like blind tube extension from the CECUM.Appendicitis: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.Appendectomy: Surgical removal of the vermiform appendix. (Dorland, 28th ed)Retroperitoneal NeoplasmsDigestive System Abnormalities: Congenital structural abnormalities of the DIGESTIVE SYSTEM.Retroperitoneal Space: An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Gene Duplication: Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Cystadenoma, Serous: A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)Cystadenoma, Papillary: A benign neoplasm of the ovary.Mucocele: A retention cyst of the salivary gland, lacrimal sac, paranasal sinuses, appendix, or gallbladder. (Stedman, 26th ed)Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Epididymal Secretory Proteins: Proteins secreted by the epididymal epithelium. These proteins are both tissue- and species-specific. They are important molecular agents in the process of sperm maturation.CA-125 Antigen: Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Skin Neoplasms: Tumors or cancer of the SKIN.Granulosa Cell Tumor: A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.Granulosa Cells: Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).Endodermal Sinus Tumor: An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Sertoli Cell Tumor: Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Ovarian Follicle: An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.Omentum: A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Fallopian Tubes: A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Fallopian Tube Diseases: Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Endothelium, Lymphatic: Unbroken cellular lining (intima) of the lymph vessels (e.g., the high endothelial lymphatic venules). It is more permeable than vascular endothelium, lacking selective absorption and functioning mainly to remove plasma proteins that have filtered through the capillaries into the tissue spaces.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Cell Surface Extensions: Specialized structures of the cell that extend the cell membrane and project out from the cell surface.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Gingiva: Oral tissue surrounding and attached to TEETH.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.HydrazinesMelanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.MyoglobinuriaAlkaptonuria: An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.Jaundice, Obstructive: Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.Audiovisual Aids: Auditory and visual instructional materials.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Abdominal Pain: Sensation of discomfort, distress, or agony in the abdominal region.Jaundice, Neonatal: Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)World War I: Global conflict primarily fought on European continent, that occurred between 1914 and 1918.Famous PersonsVermontNew HampshireJournal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Lymphangioma: A benign tumor resulting from a congenital malformation of the lymphatic system. Lymphangioendothelioma is a type of lymphangioma in which endothelial cells are the dominant component.Lymphangioma, Cystic: A cystic growth originating from lymphatic tissue. It is usually found in the neck, axilla, or groin.ThymineDatura: A plant genus of the family SOLANACEAE. Members contain TROPANES. The common name of trumpet flower is also sometimes used for GELSEMIUM.ValeratesCarbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Societies, Medical: Societies whose membership is limited to physicians.Manuscripts, MedicalAfrican Americans: Persons living in the United States having origins in any of the black groups of Africa.Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)Pleural Neoplasms: Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Asbestos: Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.Aphakia, Postcataract: Absence of the crystalline lens resulting from cataract extraction.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Zeolites: Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed)Cecal Diseases: Pathological developments in the CECUM.Bronchogenic Cyst: A usually spherical cyst, arising as an embryonic out-pouching of the foregut or trachea. It is generally found in the mediastinum or lung and is usually asymptomatic unless it becomes infected.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Mediastinal Cyst: Cysts of one of the parts of the mediastinum: the superior part, containing the trachea, esophagus, thoracic duct and thymus organs; the inferior middle part, containing the pericardium; the inferior anterior part containing some lymph nodes; and the inferior posterior part, containing the thoracic duct and esophagus.Esophageal Cyst: Any fluid-filled closed cavity or sac (CYSTS) that is lined by an EPITHELIUM and found in the ESOPHAGUS region.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Bronchopulmonary Sequestration: A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.Diverticulum, Esophageal: Saccular protrusion beyond the wall of the ESOPHAGUS.Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Thoracotomy: Surgical incision into the chest wall.Sulfoglycosphingolipids: GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.Lactosylceramides: Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.N-Acylsphingosine Galactosyltransferase: An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Glycosphingolipids: Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Sulfotransferases: Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Rare Diseases: A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.Nasal Cavity: The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.EuropeNeoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Borderline ovarian tumours in Vaud, Switzerland: incidence, survival and second neoplasms. (1/75)

Between 1976 and 1996, 176 borderline ovarian tumours were registered in the Cancer Registry of the Swiss canton of Vaud, corresponding to an age-adjusted incidence (world standard) of 2.7 in 100,000. Incidence rose from 1.7 per 100,000 during 1976-81 to 2.7 per 100,000 during 1987-91, and then levelled off; 58% of cases were serous and 41% mucinous. Relative survival was 94% at 10 years; 18 second neoplasms were observed, compared with 10.3 expected, and there was a significant excess of invasive ovarian cancers (four observed, including three synchronous, compared with 0.4 expected).  (+info)

Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? (2/75)

OBJECTIVE: To determine whether the long-term behavior of cystic mucinous neoplasms of the pancreas could be predicted using a novel, precisely defined classification of benign mucinous cystadenomas, noninvasive proliferative cystic mucinous neoplasms, and invasive mucinous cystadenocarcinomas. The primary interest was to obtain long-term follow-up after complete resection to determine the recurrence rates based on this objective classification. BACKGROUND: Current understanding is that all cystic mucinous neoplasms of the pancreas are potentially malignant and that mucinous cystadenomas, when completely removed, are biologically benign. Cystadenocarcinomas are thought to be less aggressively malignant than ordinary ductal adenocarcinoma, but reported recurrence rates vary widely and are unpredictable. METHODS: All patients who underwent "curative" resection for cystic mucinous neoplasms at Mayo Clinic Rochester from 1940 to 1997 were identified. All available pathology slides, gross specimens, and clinical records were reviewed, eliminating patients with inadequate documentation. Neoplasms were reclassified as mucinous cystadenomas, noninvasive proliferative mucinous cystic neoplasms, or invasive cystadenocarcinomas based on specific histologic criteria. RESULTS: Of 84 patients (70 women, 14 men) with cystic mucinous neoplasms of the pancreas, 54 were classified as cystadenomas, 23 as noninvasive proliferative cystic mucinous neoplasms, and only 7 as cystadenocarcinomas. Recurrent disease developed in none of the 77 patients without invasion, but 5 of the 6 patients surviving resection for cystadenocarcinomas died of recurrent cystadenocarcinoma within 5 years. CONCLUSIONS: When the neoplasm is completely resected and subjected to adequate histopathologic examination based on these objective criteria, absence of tissue invasion predicts a curative operation and detailed follow-up may be unnecessary. In contrast, a histologic diagnosis of invasive cystadenocarcinoma portends a dismal prognosis, similar to that of typical ductal adenocarcinoma of the pancreas.  (+info)

Allelotyping defines minimal imbalance at chromosomal region 17q25 in non-serous epithelial ovarian cancers. (3/75)

Allelic deletions of multiple chromosome 17q loci in sporadic ovarian cancer of epithelial origin suggest that inactivation of tumor suppressor gene(s) in these regions may be important for ovarian tumorigenesis. To further define the pattern of allelic imbalance in epithelial ovarian tumors of different histologies, a PCR-based assay was used to assess loss of heterozygosity (LOH) of polymorphic markers representative of TP53, BRCA1, NME1 and GH1, and region 17q23-25. LOH was observed for at least one marker in 68% of malignant tumors (n=60) and in 18% tumors of borderline malignancy (n=11), but not in benign tumors (n=5). The highest frequency of LOH in malignant tumors (64%) was observed with D17S801 on 17q25. Ten of 39 malignant ovarian tumors displaying LOH of at least one 17q marker, displayed a LOH pattern enabling the determination of a minimal region of overlapping deletion defined by D17S795 and D17S801. One borderline tumor also displayed an interstitial LOH pattern that overlapped this 17q25 minimal region of deletion. The histologies of malignant tumors displaying a pattern indicative of interstitial 17q deletions were of the endometrioid, clear cell and mucinous epithelial types. As the minimal region of overlap defined by these tumors overlap regions deleted in malignant tumors of all histologic types, and in a tumor of borderline malignancy, the 17q25-tumor suppressor may be implicated in the development of all types of epithelial ovarian tumors.  (+info)

Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma. (4/75)

In the present study we examined the localization and overexpression of heat shock proteins (hsps), mainly hsp90, in pancreatic carcinoma tissue compared with control tissue (including chronic pancreatitis and normal pancreas tissue), with the aid of immunohistochemical staining, in situ hybridization and reverse transcriptase polymerase chain reaction. Hsp90 alpha mRNA was overexpressed more highly in pancreatic carcinoma than in the control tissue. The proliferating-cell-nuclear-antigen labeling index was also high in pancreatic carcinoma tissue compared with the other tissue. These findings suggest that the overexpression of hsp90 alpha mRNA in carcinomas may be correlated with cell proliferation. However, hsp90 beta was constitutively overexpressed almost equally in all groups of pancreatic tissue including pancreatic carcinoma, chronic pancreatitis and normal pancreas tissue. Immunohistochemical staining demonstrated a differentiation in the expression of hsp90 between histological types of pancreatic carcinoma. These findings suggest that hsp90 alpha is involved in carcinogenesis and that hsp90 beta is correlated to structural conformation. Hsp90 alpha and hsp90 beta seem to perform different functions in tissue containing malignant cells. P53, MDM2 and WAF1, that were cell-cycle-related oncogene product were more strongly expressed in the nuclei of the cancer cells of the cancer tissue. Especially, MDM2 was more strongly expressed in mucinous carcinoma and the mucin secreting tissues surrounding pancreatic carcinoma tissue. The expression of MDM2 protein might also be correlated to secretion systems during structural conformation and be correlated to hsp90 beta.  (+info)

P73 gene expression in ovarian cancer tissues and cell lines. (5/75)

Thep73 gene, a homology of p53, is a new candidate of imprinting and tumor suppressor gene. To investigate the role of p73 in ovarian cancer, we studied the allelic expression in 56 cases of ovarian cancer using StyI polymorphism analysis. We also examined p73 expression by semi-quantitative reverse transcription-PCR as well as by Western blot analysis and DNA methylation study of the CpG island in exon 1 in ovarian cancer tissues and cell lines. Loss of heterozygosity was found in 8.3% (2 of 24) of the cases. Biallelic expression was demonstrated in 91.7% (22 of 24) of the tumor samples, in 70.8% (17 of 24) of the normal samples, and in 1 ovarian cancer cell line. Imbalanced expression and monoallelic expression were found in three and two pairs of matched samples, respectively. Overexpression of p73 was found in advanced ovarian cancer rather than in early-stage disease or in borderline ovarian tumor. No significant difference was found in the p53 expression. Three cell lines with absent p73 protein expression and one tumor sample with monoallelic expression were methylated in the CpG island. Demethylation in SKOV3 cell line using 5-azacytidine can reactivate the expression of this gene in both the mRNA and the protein level. Our results indicated that p73 was not imprinted in most of the ovarian cancer and normal tissues, but it could be involved in the advanced ovarian cancer through overexpression. DNA methylation may contribute to the lack of p73 expression.  (+info)

The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation. (6/75)

Proteolysis mediated by matrix metalloproteinases (MMPs) and serine proteinases is associated with cancer invasion and metastasis. Activation of latent proMMPs, and especially the proforms of the type IV collagen degrading gelatinases A and B (proMMP-2 and proMMP-9), is thought to be a critical step in this process. We have recently found that human tumour-associated trypsin-2 is a potent activator of proMMP-9 and it also activates proMMP-2 in vitro. Trypsinogen, MMP-2, and MMP-9 are expressed in ovarian cancer. To elucidate the function of trypsin in vivo, we studied whether high concentrations of trypsinogen-1, trypsinogen-2, their alpha(1)-proteinase inhibitor (API) complexes, and tumour-associated trypsin inhibitor (TATI) are associated with proMMP-2 and proMMP-9 activation in ovarian tumour cyst fluids. Zymography and immunofluorometric analysis of 61 cyst fluids showed a significant association between high trypsin concentrations and the activation of MMP-9 (P = 0.003-0.05). In contrast, the trypsin concentrations were inversely associated with the activation of MMP-2 (P = 0.01-0.02). Immunohistochemical analysis of ovarian tumour tissue demonstrated expression of trypsinogen-2 and TATI in the secretory epithelium. MMP-2 was detected both in stromal and epithelial cells whereas MMP-9 was detected in neutrophils and macrophage-like cells in stromal and epithelial areas. These results suggest that trypsin may play a role in the regulation of the MMP-dependent proteolysis associated with invasion and metastasis of ovarian cancer.  (+info)

Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. (7/75)

This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macrophages and the expression of COX-2 and iNOS by these tumor-associated macrophages were determined. The results obtained may provide insight into the function of COX-2 and iNOS expression by tumors. The expression of COX-2 and iNOS in tumor cells and macrophages was assessed in 18 malignant, 15 borderline, and 14 benign human ovarian tumors by immunohistochemical staining of frozen tissue sections. The intra- and peritumoral macrophages were stained using an anti-CD68 monoclonal antibody. Most of the malignant tumors (15 of 18), 10 of 15 borderline, and 9 of 14 benign tumors showed COX-2 expression in the epithelial cells, a result which indicates that COX-2 expression is not exclusive to malignancy. In addition, COX-2 staining was more intense in the epithelial cells of benign and borderline tumors than in malignant tumors. Weak iNOS staining was observed in 5 of 18 malignant, 4 of 15 borderline, and 5 of 14 benign tumors. The number of tumor-associated macrophages varied widely between the different tumors. The highest number of tumor-associated macrophages (> or =20/0.125 mm(2)) was observed in malignant tumors, whereas low to moderate intra- and peritumoral macrophage infiltration (5-20/0.125 mm(2)) was observed in the borderline and benign tumors. COX-2-positive tumor-associated macrophages were found in 3 of 18 malignant tumors, 7 of 15 borderline tumors, and 1 of 14 benign tumors. The number of COX-2-positive tumor-associated macrophages ranged from 3 to 30% of the total macrophage population. Some malignant (4 of 18), borderline (5 of 15), and benign (2 of 14) tumors contained iNOS-positive macrophages. Notable was that COX-2- and iNOS-positive macrophages were predominantly located in the tumor stroma, the regions between tumor and stroma, and in the lumina of the tumor when located in the tumor tissue. These data indicate that not only malignant but also borderline and benign ovarian tumors can exhibit increased levels of COX-2 and iNOS expression. In addition, a small proportion of the tumor-associated macrophages found in malignant, borderline, and benign tumors seems to be in an activated state, judged by their iNOS and COX-2 expression. This subpopulation of tumor-associated macrophages was invariably located in the tumor stroma or in the lumina of the tumor, specifically suggesting that macrophages outside the tumor can be tumor cytotoxic.  (+info)

Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer. (8/75)

Recently, some studies have shown that delayed scanning with (18)F-FDG PET may help to differentiate malignant from benign pancreatic lesions. However, no study has evaluated the relationship between temporal changes in (18)F-FDG uptake and expression of hexokinase or glucose transporter. METHODS: Twenty-one consecutive patients with pancreatic cancer were studied preoperatively by dual-phase (18)F-FDG PET, performed 1 and 2 h after injection of (18)F-FDG. The standardized uptake value (SUV) of the pancreatic cancer was determined, and the retention index (RI) (%) was calculated by subtracting the SUV at 1 h (SUV1) from the SUV at 2 h (SUV2) and dividing by SUV1. The percentages of cells strongly expressing hexokinase type-II (HK-II) and glucose transporter-1 (GLUT-1) were scored on a 5-point scale (1 = 0%-20%, 2 = 20%-40%, 3 = 40%-60%, 4 = 60%-80%, 5 = 80%-100%) by visual analysis of immunohistochemical staining of paraffin sections from the tumor specimens using anti-HK-II and anti-GLUT-1 antibody (HK-index and G-index, respectively). RESULTS: SUV2 (mean +/- SD, 5.7 +/- 2.6) was higher than SUV1 (5.1 +/- 2.1), with an RI of 8.5 +/- 11.0. Four cases of cancer, in which SUV2 showed a decline from SUV1, showed a low HK-index (1.8 +/- 1.1), whereas 4 cases with an RI of > or =20 and 13 cases with an intermediate RI (0-20) showed significantly higher HK-indices (4.3 +/- 0.7 and 3.1 +/- 1.5, respectively; P < 0.05). RI showed a positive correlation with HK-index, with an R(2) of 0.27 (P < 0.05), but no significant correlation with the G-index. SUV1 showed no relationship with the HK-index but showed a weak positive correlation with the G-index, with an R(2) of 0.05 (P = 0.055). CONCLUSION: These preliminary findings suggest that the RI obtained from dual-phase (18)F-FDG PET can predict HK-II expression and that the SUV (at 1 h) has a positive correlation with GLUT-1 expression but not with HK-II expression.  (+info)

*Mucinous cystadenocarcinoma

... is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ... Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case ... http://radiopaedia.org/articles/mucinous-cystadenocarcinoma-of-ovary. ...

*Mucinous cystadenocarcinoma of the lung

... mucinous bronchioloalveolar carcinoma, signet ring cell adenocarcinoma, mucinous cystadenocarcinoma, and mucinous "colloid" ... may be of use in differentiating primary mucinous cystadenocarcinoma of the lung from metastatic lung tumors due to mucinous ... Mucinous cystadenocarcinoma of the lung (MCACL) is a very rare malignant mucus-producing neoplasm arising from the uncontrolled ... Butnor KJ, Sporn TA, Dodd LG (2001). "Fine needle aspiration cytology of mucinous cystadenocarcinoma of the lung: report of a ...

*Ovarian cancer

Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... It includes serous tumour, endometrioid tumor, and mucinous cystadenocarcinoma. Less common tumors are malignant Brenner tumor ... Advanced mucinous adenocarcinomas have a poor prognosis, generally worse than serous tumors, and are often resistant to ... Estrogen HRT with or without progestins increases the risk of endometrioid and serous tumors but lowers the risk of mucinous ...

*Salivary gland tumour

Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low-grade cribriform cystadenocarcinoma Mucinous ...

*Peritoneal carcinomatosis

... mimicking liver cysts in case of mucinous cystadenocarcinoma ovary in a 52 year old female patient. Fig. 15. Case of "wet type ... is a rare complication of mucinous tumours of appendiceal or ovarian origin that results in peritoneal and omental implants. ...

*Pancreatic mucinous cystic neoplasm

These are designated either "mucinous cystadenocarcinoma" or "mucinous cystic neoplasm with an associated invasive carcinoma." ... Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of ... "mucinous cystic neoplasm with moderate dysplasia," "borderline mucinous cystic neoplasm," and "mucinous cystic neoplasm with ... Most mucinous cystic neoplasms arise in women (95%) and these women are usually in their 40s or 50s. Clinically many mucinous ...

*List of MeSH codes (C04)

... cystadenocarcinoma, mucinous MeSH C04.557.470.200.025.480.230 --- cystadenocarcinoma, papillary MeSH C04.557.470.200.025.480. ... cystadenocarcinoma, mucinous MeSH C04.557.470.590.480.230 --- cystadenocarcinoma, papillary MeSH C04.557.470.590.480.240 --- ... cystadenocarcinoma, serous MeSH C04.557.470.590.485 --- cystadenoma MeSH C04.557.470.590.485.225 --- cystadenoma, mucinous MeSH ... mucinous, and serous MeSH C04.557.470.590.075 --- adenocarcinoma, mucinous MeSH C04.557.470.590.340 --- carcinoma, ...

*Testicular cancer

... borderline malignancy Serous carcinoma Well differentiated endometrioid tumor Mucinous cystadenoma Mucinous cystadenocarcinoma ...

*Cystic lesions of the pancreas

Pancreatic mucinous cystadenoma Pancreatic mucinous cystadenocarcinoma Parra-Herran, C. E.; Garcia, M. T.; Herrera, L; Bejarano ... Pancreatic serous cystadenoma Pancreatic serous cystadenocarcinoma Pancreatic mucinous cystic tumors (13.4%) ... Pancreatic intraductal papillary mucinous tumors (most common diagnosis - 52.6%) Pancreatic serous cystic tumors (20.6%) ... Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining. Age at presentation, ...

*Pseudomyxoma peritonei

... several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma), as well as other ... Low-grade mucinous adenocarcinoma is used by the American Joint Committee on Cancer and World Health Organization and is nearly ... The term mucinous adenocarcinoma is used in different contexts depending on the reference material used by the pathologist for ... For low-grade mucinous adenocarcinoma, disease may be designated as "benign" because tumors do not invade deeply into tissue ...

*Pancreatectomy

... mucinous/serous) Cystadenocarcinoma Islet cell tumors (neuroendocrine tumors) Papillary cystic neoplasms Lymphoma Acinar cell ...

*Ovarian tumor

It includes serous tumour, endometrioid tumor, and mucinous tumour. They can be benign (cystadenoma) or malignant ( ... cystadenocarcinoma). Less common tumors are malignant Brenner tumor and transitional cell carcinoma of the ovary. Sex cord- ...

*International Classification of Diseases for Oncology

M8470/2 Mucinous cystadenocarcinoma, non-invasive (C25._) M8470/3 Mucinous cystadenocarcinoma/ NOS (C56.9) Pseudomucinous ... NOS M8471/3 papillary mucinous cystadenocarcinoma (C56.9) Papillary pseudomucinous cystadenocarcinoma M8472/1 Mucinous cystic ... Papillary mucinous tumor of low malignant potential M8480/0 Mucinous adenoma M8480/3 Mucinous adenocarcinoma Mucinous carcinoma ... M9015/3 Mucinous adenocarcinofibroma Malignant mucinous adenofibroma Mucinous cystadenocarcinofibroma Malignant mucinous ...

*Cystadenoma

... mucinous cystadenoma (8470-8473) Bile duct cystadenoma (8161) Endometrioid cystadenoma (8380) Appendiceal mucinous cystadenoma ... When malignant, it is called cystadenocarcinoma. When not otherwise specified, the ICD-O coding is 8440/0. However, the ... Picture of serous cystadenoma Serous cystadenoma of pancreas at eMedicine Biliary cystadenoma/cystadenocarcinoma at eMedicine ...

*Surface epithelial-stromal tumor

As primary ovarian mucinous tumors are usually unilateral (in one ovary), the presentation of bilateral mucinous tumors ... 75% are benign or of borderline malignancy, and 25% are malignant The malignant form of this tumor, serous cystadenocarcinoma, ... of primary mucinous tumors are bilateral. May form very large cystic masses, with recorded weights exceeding 25 kg Mucinous ... Mucinous tumors: Closely resemble their serous counterparts but unlikely to be bilateral Somewhat less common, accounting for ...

*Pancreatic serous cystadenoma

... such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm), serous cystic neoplasms are almost ... "serous cystadenocarcinoma". Serous cystic neoplasms can come to clinical attention in a variety of ways. The most common ... Ovarian serous cystadenoma Pancreatic mucinous cystadenoma Solid pseudopapillary neoplasm Colonna, J.; Plaza, JA.; Frankel, WL ...

*Liver cancer

Less common types include mucinous cystic neoplasm and intraductal papillary biliary neoplasm. The diagnosis may be supported ... Cancer of the bile duct (cholangiocarcinoma and cholangiocellular cystadenocarcinoma) account for approximately 6% of primary ...

*Hereditary nonpolyposis colorectal cancer

... intestinal adenoma Ovarian serous cystadenocarcinoma Individuals with HNPCC have about an 80% lifetime risk for colon cancer. ... right-sided poorly differentiated cancers right-sided mucinous cancers adenocarcinomas in any location showing any measurable ...
Mucinous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ovary. Tumors are normally multilocular with various smooth, thin walled cysts. Within the cysts is found a haemorrhagic or cellular debris. Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case report and review of the literature". Arch. Pathol. Lab. Med. 127 (8): 1031-3. doi:10.1043/1543-2165(2003) ...
The etiology and biological behavior of PRMCs are still unclear; however, some hypotheses have been proposed to explain the genesis of these tumors as follows: (1) heterotopic ovarian tissue [3, 11, 47], (2) monodermal variant of teratomas [22, 48], (3) intestinal duplication [49], and (4) coelomic metaplasia [4, 8, 12, 50]. In our case, ovarian-like stroma was histopathologically found in the tumor, although no definitive evidence of ovarian tissue was observed, which was also supported by the results of an immunohistochemical examination of the estrogen and progesterone receptors. These findings exclude the hypothesis of heterotopic ovarian tissue. In addition, the hypotheses of teratoma and intestinal duplication can also be excluded because of the lack of structures of teratoma or well-developed intestinal mucosa and smooth muscle. The fourth hypothesis, which is most well-described in the previous literature, is that PMRCs occur from invaginations of the peritoneal epithelium during ...
Pancreatic cystadenocarcinoma is an extremely rare neoplasm in pregnancy. To our knowledge, there have been 2 published cases of pancreatic mucinous cystadenocarcinoma (PMC) during pregnancy in the literature; one of which was reported to have ruptur
Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of cystic neoplasms that arise from the pancreas. They may be benign, malignant or in between. The prognosis of this set of tumours is highly variable and dependent on the specific sub-classification (benign, borderline, malignant). Mucinous cystic neoplasms of the pancreas are defined by the World Health Organization (WHO) as cystic epithelial neoplasms that occur almost exclusively in women; do not communicate with the pancreatic ductal system and which are composed of columnar, mucin-producing epithelium, supported by ovarian-type stroma. This means that these tumors make mucin (a thick sticky fluid), they do not arise in the larger pancreatic ducts, and they have a peculiar supporting stroma (or support structure). Mucinous cystic neoplasms of the pancreas classified as benign, borderline, or malignant, based on histomorphological features which predict their ...
This is my first post and I am hoping someone might be able to help. Can I first just say how helpful it has been over the last few months reading everyones comments and knowing what to expect. I ...
Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors ...
Semantic Scholar extracted view of EDUCATION AND IMAGING. Hepatobiliary and Pancreatic: Long-term survival of serous cystadenocarcinoma of the pancreas with synchronous liver metastases after aggressive surgical resection. by Hayato Sasaki et al.
Some authors believe the term microcystic serous adenoma is too limiting and that a macrocystic variant of the same neoplasm exists; the term serous cystadenoma is thus used for both morphologic variants.Nevertheless, the term macrocystic serous tumor is useful; these tumors are often misdiagnosed as either mucinous cystic neoplasms or pseudocysts. In fact, some tumors are misclassified even with intraoperative frozen section. Serum tumor markers with macrocystic serous tumors tend to be normal, although CA 125 and CA 19-9 are elevated in the cyst fluid in some of these tumors. The macrocystic variant of serous adenoma consists of a small uni- or bilocular cyst containing a thin wall without any mural nodules; these are indistinguishable from mucinous cystic tumors ...
We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The thing is you may have more than one cysts and though 1 had ruptured, it can cause others to be inflamed or prone to break - like a chain reaction.. It seems that in patients whom follow a treatment against infertility with womanly hormones like FSH the risk of functional cysts to form is very high. Macrophages killed the cysts by phagocytosis, whereas neutrophils wiped out cysts through the secretion of MPO.. Individuals were followed up 24 instances of being pregnant 15 instances of infertility, pregnancy level 62. 5%; 5 instances confirmed recurrence, the recurrence rate was 5. 3%. Conclusions Laparoscopic surgical injury, quicker recovery, pelvic obvious vision, releasable pelvic adhesions in individuals with increased being pregnant rate of infertility, ovarian endometriosis must be used since the preferred way of cyst. ...
Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4-140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCNs related mortality was 0.1% (n=1). ...
Low-grade cribriform cystadenocarcinoma of salivary glands Definition : Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described (...)
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Gynecology: Polyembryoma ovarian | surgery treatment. Treatment in Marburg, Germany ✈ Find the best medical programs at BookingHealth - ✔Compare the prices ✔Online booking.
have been recently diagnosed at hospital or in private-sector for the following diseases: Local or metastatic cancer diagnosed less than 6 month (breast cancer-hormone sensitive- in first line chemotherapy treatment, hormone-sensitive prostate cancer or in metastatic recurrence after 3 years of remission, considered as a new case, colorectal cancer in first line chemotherapy treatment), a neuro-degenerative disease (Parkinson disease diagnosed less than 7 years, Alzheimer disease and similar diseases diagnosed less than 12 months and /or with a Mini Mental State Examination (MMSE ...
Despite being implicated in multiple types of human epithelia-origin cancer, laminin-binding (LB) integrins (e.g., α3α1 and α6β4) have rarely been investigated for their roles in human ovarian tumors. More recently, we and others have shown that CD151, a member of the tetraspanin family, not only forms tight surface complexes with these adhesion receptors, but also mediates the malignancy of human carcinomas largely in a LB integrin-dependent manner. Here we report our studies on the role of CD151 in human ovarian cancer. Initially, we stained human ovarian tumor tissue microarrays with CD151-specific antibody. Our data showed that the majority of ovarian tumors exhibited a reduced expression of CD151 protein, compared to the fallopian tube, implying a putative suppressing role of this tetraspanin in ovarian cancer. With this hint we next evaluated the impact of CD151 ablation on the behaviors and proliferation of cultured human ovarian cancer cells. While CD151 removal had a minimal impact ...
Metastatic neoplasms are secondary ovarian tumors. The main sources of metastasis are carcinomas of the stomach, intestines, breast and uterus.
From one of the patients included, the original x-ray coronary angiogram could not be traced by the referring cardiologist. Furthermore, the two independent observers reviewing all x-ray coronary angiograms both judged that the coronary angiogram of 1 patient could not be analyzed because it was an incomplete study. Of the remaining 36 films, observer A judged 19 angiograms to show normal coronary anatomy and 17 to show anomalously arising coronary arteries, whereas observer B judged 20 to show normal and 16 to show anomalous anatomy. Interobserver agreement for differentiating anomalous from normal coronary anatomy was 97%. In 5 of the patients, there was difference in opinion about the site of origin of an (anomalous) artery. In 4 of these 5 patients, the disagreement consisted of one of the observers having labeled the origin of an anomalous artery as "unclear," whereas the other had specified an anomalous origin (in 3 patients, an anomalous origin of the RCA from or from above the left sinus ...
TY - JOUR. T1 - Primary pancreatic cystic neoplasms revisited. Part I. T2 - Serous cystic neoplasms. AU - Sakorafas, George H.. AU - Smyrniotis, Vasileios. AU - Reid-Lombardo, Kaye M.. AU - Sarr, Michael G.. PY - 2011/6. Y1 - 2011/6. N2 - Primary pancreatic cystic neoplasms have been recognized increasingly during the two recent decades and include mainly serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. Serous cystic neoplasms represent about 30% of all cystic neoplasms of the pancreas and are characterized by their microcystic appearance (on imaging, macroscopically, and microscopically) and their benign biologic behavior. Modern diagnostic methodology allows the preoperative diagnosis with an acceptable accuracy. Currently, indications for resection of serous cystic neoplasms of the pancreas include the presence of symptoms, size , 4 cm (because these large neoplasms have a more rapid growth rate and probably will soon become symptomatic), and ...
A close-up of the smooth appendiceal luminal surface is shown. Differential diagnosis included mucocele, mucinous cystadenoma, mucinous cystadenocarcinoma and less likely, carcinoid ...
The only method you can actually tell how big an ovarian cyst is by going into your physician for an ultrasound. However, kids arent spared of Dermoid cysts - often children get them near to the eyebrows spectrum of ankle aspect and so they feel like rubberized. Many different steps are there in treating Ovarian cyst patients in respect to their person condition. Mucinous cystadenocarcinoma is usually unilateral and involve the existence of irregular dense septa or solid papillary projections which can be usually recognized within cysts ( Fig.. There are generally only a couple of options for treatment; one is surgical removal of the cysts, and the additional is body hormone treatment by means of birth control supplements. She was told the fact that ultrasound search within will be repeated in a few a few months time; in the event the cysts develop larger, they need to be eliminated by medical procedures.. However , a functional cyst may interrupt your menstrual cycle simply by preventing ...
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
Cystic neoplasms of the pancreas represent about 10% of all cysts of the pancreas and ~1% of all pancreatic neoplasms. Much has been learned about the natural history and management of these tumors in the past decade. We are finding more of these lesions than in years past since so many patients receive ultrasounds or CT scans for other reasons and these tumors are found incidentally. Cystic neoplasms are subdivided into serous, mucinous and intraductal papillary mucinous neoplasms. These lesions are described separately on this website but a few generalities pertain to all. The most important aspect of these lesions is to recognize them. They must be differentiated from benign pancreatic cysts as the treatment is distinctly different. Differentiation of benign cysts from cystic neoplasms of the pancreas can usually be made by a good history and physical exam by a physician familiar with these disorders. If a cystic neoplasm is suspected and the patient is symptomatic (abdominal pain), surgical ...
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed ...
This 4 arm study will assess the optimal starting dose of Mircera in the treatment of anemia in patients with non-small cell lung cancer receiving first
See also pancreatic anomalies simple mucinous cyst Open references A Revised Classification System and Recommendations From the Baltimore (...)
Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...
A 40-year-old Japanese woman, who previously had undergone choledocho-jejunostomy in childhood for a congenital choledocal cyst, presented with right-sided chest pain. Computed tomography and ultrasonography demonstrated a right pleural effusion and a 10-cm unilocular hepatic cystic lesion with no solid component. These findings suggested a non-neoplastic cyst or cystadenoma. However, intracystic fluid aspirated had high concentrations of carbohydrate antigen 19-9 and carcinoembryonic antigen. Cytology of the pleural effusion demonstrated malignant cells. During exploratory laparo- and thoracotomy, a hepatic cystadenocarcinoma with invasion of the diaphragm and pleural dissemination was discovered. This case demonstrates that malignancy should be ruled out when a patient with an intrahepatic unilocular cystic lesion presents with atypical symptoms and findings, such as chest pain, pleural effusion, and high serum concentration of tumor markers. We believe that intrahepatic cystic lesions should be
MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma / pathology. Carcinoma / secondary. Carcinoma / surgery. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / secondary. Carcinoma, Small Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / secondary. Cystadenocarcinoma, Mucinous / surgery. Diagnosis, Differential. Female. Humans. Male. Mesothelioma / pathology. Mesothelioma / surgery. Middle Aged. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritonitis / pathology. Pseudomyxoma Peritonei / pathology. Pseudomyxoma Peritonei / ...
Eighty five ovarian epithelial and non-epithelial tumours were studied by peroxidase histochemical staining for their reactivity with six monoclonal human milk fat globule (HMFG) antibodies, peanut agglutinin (PNA) lectin, and a monoclonal cytokeratin antibody. HMFG IIIC12 and cytokeratin antibodies distinguished epithelial from non-epithelial tumours. The staining patterns of mucinous and serous tumours were essentially different from each other; poorly differentiated anaplastic carcinomas showed similar antigenic content to that of the serous cystadenocarcinomas. Furthermore, staining with PNA lectin and HMFG antibodies was useful in distinguishing clear cell carcinomas from other malignant epithelial tumours of the ovary.. ...
Endoscopic ultrasound will be used to locate and assess the pancreatic cyst. The fluid contents will be aspirated using a fine needle and sent for tumor marker analysis and cytology. With the needle maintained in the same position, 99% ethanol will be injected into the cyst. After 3-5 minutes of lavage, the entire volume of fluid will be removed from the cyst. The same volume of paclitaxel minus 1 mL [3mg/ml diluted in normal saline from original concentration of 6mg/mL] will be injected and left in the cyst. The needle is then retracted and the procedure completed. Patients will receive oral prophylactic antibiotics for 5 days after the procedure. Clinical follow up with MRI imaging with be done at 6, 12, 18, and 24 months. For those with a persistent cyst at 12 months, a repeat EUS FNI procedure will be done ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Patients were administered FOLFIRI every 2 weeks in one course. FOLFIRI:CPT-11 150 mg per square meter on day1 with l-LV 200 mg per square meter administered as a 2-hour infusion before 5-FU 400 mg per square meter administered as an intravenous bolus injection, and 5-FU 2400 mg per square meter as a 46-hour infusion immediately after 5-FU bolus injection on day1 in 2 weeks ...
Purpose: Pancreatic cysts are common and pose diagnostic and management challenges. Pancreatic cyst fluid markers have the potential to aid in the management of cysts with concerning imaging findings. Our aim was to evaluate cyst fluid methylated DNA markers for their accuracy for predicting the histologic grade of neoplastic pancreatic cysts. Experimental Design: Pancreatic cyst fluid samples from 183 patients (29 discovery, 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4 and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP). Methylated DNA levels were evaluated for their accuracy at predicting the grade of dysplasia of the pancreatic cyst. Results: All six markers evaluated in the validation set could accurately distinguish high-risk cystic neoplasms (with high-grade dysplasia and/or associated invasive cancer) from low-risk cysts (lower grades of dysplasia) with accuracies from 79.8 ...
An Unusual Association of Lung and Ovarian Malignancy in a Young Nonsmoker Female: 10.4018/ijudh.2012100104: Lung cancer in a 25-year-old nonsmoker female is extremely rare. Ovarian malignancy in this age group is also infrequent and if occurs, is usually of germ
Cystadenoma most often occurs in middle-aged women. However, cystadenocarcinoma equally affects both men and women. Most patients are asymptomatic or have vague abdominal complaints of bloating, nause... more
Anne Marie Lennon, MD, PhD, director of the Pancreatic Cyst Clinic discusses the prevalence and optimal management of pancreatic cysts.
TAPUR stands for Targeted Agent and Profiling Utilization Registry - it is a beacon of hope for cancer patients seeking treatment when first line chemotherapy...
Cysts are responsible for secreting fluid into the cysts, that can be harmful. The Treatment For Pancreatic Cysts In Delhi available for the sufferer.
When it comes to pancreatic cysts, expert evaluation is vital to accurately diagnose the nature of the cyst, and then determine the best course of treatment.
Ovarian cancer is a silent killer; however, improvements in identification of women at high risk for ovarian cancer, as well as improved imaging techniques, have increased the likelihood of early dete... more
article{d35fd546-9f26-4935-a0e7-851f0164cd42, abstract = {Abstract Pancreatic cystic neoplasms are detected at an increasing frequency due to an increased use and quality of abdominal imaging. There are well known differential diagnostic difficulties concerning these lesions. The aim is to review current literature on the diagnostic options and the following treatment for cystic lesions in the pancreas focusing on serous cystadenomas, primary mucinous neoplasm of the pancreas and mucinous cystadenocarcinomas, as well as intraductal papillary mucinous neoplasms, starting with excluding pseudocysts. A conservative approach is feasible in patients with a clinical presentation suggestive of an asymptomatic serous cystadenoma. Surgical management, as well as follow-up, is discussed for each of the types of neoplastic lesions, including an uncharacterized cyst, based on patient data, symptoms, serum analysis, cyst fluid analysis and morphological features. Aspects for future diagnostics and management ...
Symptoms. Mucinous Cystadenocarcinomas are more common in the body and tail of the pancreas. They can be more prominent then 10 centimeters. Guess with this kind of pancreatic cancer for the most part better. Pancreatoblastomas are uncommon (0.5 percent) exocrine tumors commonly found in children under 10 years of age, however it can happen all through lifetime. Pancreatoblastomas are recognized all the more regularly in guys and Asians. They show up as a group of cells among ordinary cells. Survival is superior to with adenocarcinoma.. Serous Cystadenomas are ordinarily kindhearted tumors. They have a wipe like improvement and can be cumbersome. They are loaded with watery fluid, while mucinous cystadenomas are loaded with a thicker sticky liquid. Serous cystadenomas comprise of single or different growths averaging 5-8 cm and upwards to 25 cm in breadth. Papillary Tumors are uncommon with an inclination for young ladies principally between 19 - 50 years of age. It is a huge round very much ...
The aim of the study was to investigate long-term trends in the incidence of borderline tumors and ovarian cancer in Sweden during 1960-2005, based on data from the population-based Swedish Cancer Register. We identified 6,288 patients with borderline ovarian tumors and a total of 34,977 cases of ovarian cancer during the study period. The age-standardized incidence of borderline ovarian tumors increased from 1.0 to 5.3 per 100,000 women-years from 1960-1964 to 2000-2005 and the incidence of ovarian cancer increased from 16.4 to 19.7 per 100,000 women-years from 1960-1964 to 1980-1989 and then declined to 16.6 per 100,000 women-years to the period 2000-2005. Borderline ovarian tumors comprised 15% of all primary ovarian neoplasms and the proportion increased from 8.3 to 23.6% during the study period. The median age at diagnosis for patients with borderline ovarian tumors and ovarian cancer was 55.2 and 61.6 years, respectively. In women younger than 40 years, 34% of all primary ovarian ...
INDIANAPOLIS - Researchers at the Indiana University School of Medicine have discovered a highly accurate, noninvasive test to identify benign pancreatic cysts, which could spare patients years of nerve-racking trips to the doctor or potentially dangerous surgery.. The findings are reported in "Vascular Endothelial Growth Factor, a Novel and Highly Accurate Pancreatic Fluid Biomarker for Serous Pancreatic Cysts" online in the Journal of the American College of Surgeons.. The test, which analyzes fluid from pancreatic cysts, can identify a common type of benign cyst that cant be differentiated by imaging alone from cysts that may progress to pancreatic cancer. Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF-A. Pancreatic cyst fluid is often obtained in patients with pancreatic cysts as a part of standard testing during endoscopy. High levels of VEGF-A indicate with 99 percent accuracy that the cyst will not become malignant, ...
A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia....
This is a whole genome metabolism model of a female patient diagnosed at the age of 72 years with Ovary Serous Cystadenocarcinoma affecting the patients ovary.. This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-10-0928-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.. This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110124.. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.. To the extent possible under law, all copyright ...
This is a whole genome metabolism model of a female patient diagnosed at the age of 52 years with Ovary Serous Cystadenocarcinoma affecting the patients ovary.. This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-61-2088-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.. This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707111048.. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.. To the extent possible under law, all copyright ...
Patients median age was 60 years (28-72). All were classified as ECOG 0-1. Each patient received oxaliplatin as a first line treatment. Also prior use of bevacizumab was reported in 12 patients (60%) and anti-EGFR in 5 patients (25%). 70% of them had mutated RAS status and 30% wild-type RAS status.. The median number of cycles given was 10 (2-42). Aflibercept dose reduction was required in 6 patients (30%), and therapy discontinuation due to toxicity in 2 (10%), 1 as a consequence of hypertension and 1 as diarrhea. In all patients, some kind of grade treatment-related adverse events occurred. Most frequently 3-4 grade toxicity observed were: asthenia (20%), neutropenia (20%), hypertension (20%), diarrhea (15%), stomatitis (15%), palmar-plantar erythrodysesthesia (10%) and proteinuria (5%).. In patients evaluable for response, the response rate was 40% and the disease control rate of 73%. In a follow-up median time of 9 months, the progression-free survival median time was 6,5 months (2-23), and ...
Ovarian cancer is a cancer that forms in an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. SK-OV-3, NIH:OVCAR-3 and HO-8910 are the ovarian carcinoma cell lines derived from human ovarian tumor. Studies were carried out to determin
I am a medical oncologist with clinical and laboratory experience in cancer genetics. My research focuses on defining genetic factors that cause an increased susceptibility to cancer. My research team identified the most common mutation associated with an increased risk of breast and ovarian cancer among individuals of Ashkenazi Jewish ancestry. My MSKCC colleagues and I also published the first prospective series describing the outcome of preventive ovarian surgery and screening in women at hereditary risk for breast and ovarian cancer. Ongoing research is aimed at defining new genetic risk factors and tailored interventions for families at hereditary risk for cancers of the breast, ovary, colon, prostate, and lymphoid organs.
In a proof-of-concept study, an international scientific team led by Johns Hopkins Kimmel Cancer Centerresearchers has shown that a laboratory test using
A testicular neoplasm is a type of abnormal growth in the testicle. The main signs of a testicular neoplasm are a painless lump...
Histologically, cystoadenomas are characterised by the presence of cysts lined with mucinous cuboidal or columnar epithelium.6 An ovarian-type stroma is seen in 85% of cases and exclusively in females.4 A marsupial pseudocapsule separates the cystadenoma from the biliary epithelium.4 Elevated levels of CA 19-9 and/or CEA have been reported within the cysts themselves.1 2 4 11 12. Although the biliary cystadenoma is a benign entity, malignant transformation can occur, leading to cystadenocarcinoma.4 Sarcomatous transformation has also been described in one case.6 It has been suggested that cystadenocarcinomas arising from biliary cystadenomas with ovarian-type stroma have a relatively indolent course, whereas cystadenomas without ovarian-type stroma have a poorer prognosis.4. Most commonly, on radiologic imaging, these neoplasms appear as multi-loculated, multi-septated intrabiliary neoplasms. They are usually large at the time of presentation, with a mean tumour size of 15 centimetres.4 On CT, ...
Epithelial ovarian cancer is a leading cause of death in gynecological cancers. While several systematic studies have revealed the mutation landscape of serous epithelial ovarian cancer, other non-serous subtypes of the disease have not been explored as extensively. Here we conduct exome sequencing of nine non-serous epithelial ovarian tumors (six endometrioid and three mucinous) and their corresponding normal DNA as well as a tumor-only granulosa cell sample. We integrated the exome data with targeted gene sequencing for 1,321 genes selected for their involvement in cancer from additional 28 non-serous ovarian tumors and compared our results to TCGA ovarian serous cystadenocarcinoma and uterine corpus endometrial carcinomas ...
Pancreatic cyst: Find the most comprehensive real-world symptom and treatment data on pancreatic cyst at PatientsLikeMe. 33 patients with pancreatic cyst experience fatigue, pain, depressed mood, anxious mood, and insomnia and use Acupuncture, Aspercreme with Lidocaine, Chemotherapy, Cyclobenzaprine, and Diazepam to treat their pancreatic cyst and its symptoms.
Results During this period 267 procedures were performed on 235 individuals, of whom 71 had a definitive diagnosis (60 resection histology, 5 histology, 6 malignant cytology), cystic degeneration of pancreatic adenocarcinoma (3) being excluded. 68 patients (51 females), (78 procedures) formed the study group. There were 25 mucinous cyst adenomas (11 MCA, 14 MCAC). There were 22 IPMN (2 malignant) and 21 non-mucinous cysts.. For MCA/MCAC using a cut-off of 192 ng/ml the sensitivity, specificity, accuracy and NPV of detecting a mucinous lesion were 62.5%, 94.4%, 79.4%, 73.9%. Combining EUS morphology, cytology and visual assessment of aspirate (mucoid/non-mucoid) gave figures of 100%, 70.8%, 86%, 100%. The combination was significantly more sensitive p=0.007, but no significant difference in specificity. ROC area under the curve was numerically greater 0.861 versus 0.785 (not significant).. For the IPMN patients the cut-off 192 ng/ml showed a sensitivity of 20% in the diagnosis of IPMN. EUS ...
Background:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers.Methods:All consecutive patients with primary RPS treated at 6 European and 2 North American institutions between January 2002 and December 2011 were included. Five, 8, and 10-year overall survival (OS) and crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM) were calculated. Multivariate analyses for OS, CCI of LR, and DM were performed.Results:In all, 1007 patients were included. Median follow-up was 58 months (first and third quartile range 36-90). The 5, 8, and 10-year OS were 67% [95% confidence interval (CI), 63, 70), 56% (95% CI, 52, 61), and 46% (95% CI, 40, 53). The 5, 8, and 10-year CCI of LR and DM were 25.9 (95% CI, 23.1, 29.1), 31.3 (95% CI, 27.8, 35.1), 35% (95% CI, 30.5, 40.1), and 21% (95% ...
Mark D. Topazian, M.D., of the Division of Gastroenterology and Hepatology at Mayo Clinic in Rochester, Minn., discusses endoscopic diagnosis and management of pancreatic cysts, including efforts to refine criteria for resection of mucinous cysts and EUS-guided ethanol ablation.. ...
There are several types of cystic tumors or neoplasms of the pancreas, each with malignant potential that varies from nearly zero to up to 70% depending on the type. Distinguishing a neoplasm from a pseudocyst and distinguishing among the different types of neoplasm is often straightforward, but at times can be challenging.
In a look-back analysis of data stored on 130 patients with pancreatic cysts, scientists at Johns Hopkins have used gene-based tests and a fixed set of clinical criteria to more accurately distinguish precancerous cysts from those less likely to do harm.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain ...
Simple pancreatic cyst versus pseudocyst versus cystic neoplasm to the tail of pancreas, measures 5mm. No blood flow to cyst on ultrasound. Should be eval. with CT of abdomen and pancreas. Mobile s...
Pediatric musculoskeletal neoplasms are relatively rare. They can be categorized as either benign or malignant, as has been done for this document. Musculoskeletal neoplasms are often also categorized by the type of tissue they produce or from which they are derived. The most common types of tumors that affect the musculoskeletal system are cysts, bone-producing tumors,
Neoplasia describes a process involved in several different diseases. It is therefore difficult to give an all-encompassing definition. However, it is generally recognized that neoplasia is the uncontrolled, abnormal growth of cells or tissues in the body, prior to a lump or abnormal growth developing. Once developed, the abnormal growth is called a neoplasm or tumor. Tumors can be benign or malignant. Benign and malignant tumours A benign tumor is a mass of cells that lack the ability to invade neighboring tissue or spread throughout the body. Benign tumors typically have an outer fibrous sheath of connective tissue and grow more slowly than malignant tumors. Malignant tumors usually grow more aggressively, they invade the tissues surrounding them and can metastasize (spread throughout the body). The actual swelling or appearance of a neoplasm is often described as a "tumor" or "mass". The word "cancer" is often used instead of neoplasia, but only malignant neoplasms are true ...
Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed ...
The present study was designed to obtain an experimental tumor model as similar as possible to human ovarian cancer which often had a large amount of ascites and to assess the therapeutic value of tranexamic acid. Human tumor cell lines which form ascites in nude mice were established from ascites of patient with serous cystadenocarcinoma of the ovary. Two cloned cell lines designated HRA and HR-1 were obtained from the parent cell line designated HR. All of these cultured cell lines had about 2.5-3.5 times higher lactate dehydrogenase activities than the original tumor. The original tumor and the tumor grown in nude mice had all 5 bands of lactate dehydrogenase isoenzymes, while all cultured cell lines had only a marked lactate dehydrogenase-3 in addition to a faint lactate dehydrogenase-2. Modal chromosome numbers of HR cells ranged from 50-76, while that of HRA cells ranged widely from 40-140. The DNA histograms of HR and HRA cells were similar to each other, showing predominant G1 and S ...
The majority of borderline ovarian tumours (BOTs) behave in a benign fashion, but some may show aggressive behavior. The reason behind this has not been elucidated. The epidermal growth factor receptor (EGFR) is known to contribute to cell survival signals as well as metastatic potential of some tumours. EGFR expression and gene status have not been thoroughly investigated in BOTs as it has in ovarian carcinomas. In this study we explore protein expression as well as gene mutations and amplifications of EGFR in BOTs in comparison to a subset of other epithelial ovarian tumours. We studied 85 tumours, including 61 BOTs, 10 low grade serous carcinomas (LGSCs), 9 high grade serous carcinomas (HGSCs) and 5 benign epithelial tumours. EGFR protein expression was studied using immunohistochemistry. Mutations were investigated by Sanger sequencing exons 18-21 of the tyrosine kinase domain of EGFR. Cases with comparatively higher protein expression were examined for gene amplification by chromogenic in ...
Pancreatic Cyst: A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)
Caffrey, P.B., and Frenkel, G.D. (2012). Selenite enhances and prolongs the efficacy of Cisplatin treatment of human ovariam tumor xenografts. In Vivo 26: 549-552.. Caffrey, P.B. and Frenkel, G.D. (2001) A prevention strategy for circumventing drug resistance in cancer chemotherapy. Current Pharmaceutical Design 7:1595-1614.. Caffrey, P.B. and Frenkel, G.D. (2000) Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo. Cancer Chemother. Pharmacol. 46: 74-78.. Caffrey, P.B., Zhu, M., Zhang, Y., Chinen, N. and Frenkel, G.D. (1999) Rapid development of glutathione S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid. Cancer Letters 136: 47-52.. Caffrey, P.B. and Frenkel, G.D. (1998) Treatment of human ovarian tumor xenografts with selenite prevents the development of melphalan-induced drug resistance. Anticancer Research 18: 3017-3020.. Caffrey, P.B., Zhang, Y. and Frenkel, G.D. (1998) Rapid development of ...
Vol 7: Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Is diarrhea and vomiting common in stage 4 lung cancer - My dad has stage 4 lung cancer with bone metastasis. Second line chemotherapy completed fully before 2 months. Now he has frequent cough and vomiting? Go to see onc. He needs to go to see his oncologist to see if his current symptom of progressive cough is related to progression of cancer- or it this is associated to something else. What type of lung cancer that your father has? If this is an adenocarcinoma of the lung maintenance therapy is something that should be considered following chemotherapy regimen. A ct scan is something he probably should get done.
Great progress has been made over the past two decades in the development of animal models for ovarian cancer. Each generation of animal model has had its advantages and limitations. The earliest models used a xenograft approach in which human ovarian tumor cells or tissues were grown in immunodeficient mice (17, 27, 32, 33, 36). The xenograft model preserved the complex interactions that occur between cancer cells and their microenvironment, including stromal-epithelial cell interactions, as well as influences of matrix proteins, growth factors, and angiogenesis. Thus, this model was a great advance over cell culture model systems and advanced the study of therapeutic interventions. However, an important weakness in the xenograft model was the lack of host immunity, which severely limited the ability to reliably predict the effect of noncancer immune-host influences on outcomes. In addition, tumors were introduced in the xenograft model rather than arising as primary lesions in the ovary, thus ...
Risk of Malignancy in Unilocular Ovarian Cystic Tumors Less Than 10 Centimeters in Diameter Susan C. Modesitt, MD, Edward J. Pavlik, PhD, Frederick R. Ueland, MD, Paul D. DePriest, MD, R. J. Kryscio, PhD,
Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME. ...
Eye cancer is the general term that covers quite wide range of tumors developing in various parts of eye tissues and in the appendage of the eye. Neoplasms are usually classified by the location site.. The most common type of malignant tumors is the eyelid cancer. The main age group of affected population is elderly people aged 50-75. Females experience eye cancer more often than males, comprising 60-85 % of the total patient population.. ...
What is Intermittent Fasting? Contrary to popular belief, intermittent fasting (IF) is actually an eating pattern. Believe it or not, you can have a healthy
Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...
Age over 70 (p = 0.031) and CA 19-9 over 300 U/mL (p = 0.015) were shown as significant predictors of malignancy. BMPCN with mural nodule (p = 0.002) and abrupt change of the bile duct (p = 0.027) was more likely in malignancy. Age over 70 (OR: 6.37, 95% CI: 1.15-35.2, p = 0.034), CA19-9 over 300 U/mL (OR: 3.97, 95% CI: 1.12-14.0, p = 0.032) and mural nodule over 20mm (OR: 10.32, 95% CI: 1.54-68.7, p = 0.016) were independent predictors of malignancy. The lesion that had more than 2 of 4 points (age over 70, CA19-9 over 300 U/mL, mural nodule over 20mm and abrupt change of the bile duct) had high accuracy for predicting malignancy (sensitivity: 84.2%, specificity: 83.3%, AUC = 0.867). ...
This single arm study will evaluate the efficacy and safety of first line chemotherapy with carboplatin and dose-dense weekly paclitaxel plus Avastin in
A laboratory test that uses molecular and clinical markers, as well as machine learning, may help improve the management of pancreatic cysts and reduce unnecessary surgeries, according to data published in Science Translational Medicine.One of the study authors, Christopher L. Wolfgang, MD, PhD, of the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins University, said that pancreatic
Long time poster, took a break for a few years, new more anonymous screen name. I am struggling so hard right now with just too many hard things to handle, and I feel like a part of my heart has been crumbled up into little pieces and its never going to be OK again. If you want the tl;dr version, Im estranged from my mentally ill parents, I just found out they are getting divorced, Im struggling with chronic illness and may need brain surgery, I definitely need ovarian surgery, I quit my therapist, I quit my job, I quit my hobbies, I quit my church, all my friends keep moving out of state, and Im just a mess and Im trying to keep it all together but all I want to do is cry because its all just SO (significant other) hard and I for real cannot keep it together anymore. Long version: My mom has narcissist personality disorder and my dad has borderline personality disorder. Weve been estranged for about 4 years since I finally told my mom No for the first time ever. She
The current best hope for the successful treatment of pancreatic cancer is the removal of pre-invasive lesions before they become malignant. The early detection...
췌장과 비장 내 낭성 병변은 방사선학적 영상검사로 진단이 비교적 쉬운 편이나, 췌장 내 부비장에서 발생한 유표피 낭종은 특이적 방사선 소견이 없어 진단하기 매우 어려워 췌장 내 낭성 종양으로 오진되기가 쉽다. 췌장 내 부비장 조직이 상대적으로 많다면, 종괴의 고형 성분이 복부 전산화 단층촬영 검사에서 비장과 비슷한 조영증강을 보이고 자기공명영상 검사에서 비장과 같은 신호 변화를 보인다는 점에서 방사선학적 영상검사로 췌장 내 부비장의 유표피 낭종을 진단 할 수 있다. 하지만 부비장 조직이 많지 않으면 정확한 진단은 매우 힘들며 본 증례에서도 수술 후 절제 조직에서 부비장 조직이 상대적으로 적게 관찰되었으며 이로 인해서 수술 전 영상검사로 정확한 진단은 할 수 없었다. 췌장 내 낭종이 있을 경우 감별진단을 해야 하는 질환으로 ...
Bethesda, MD (Oct. 23, 2014) - The American Gastroenterological Association (AGA) Research Foundation is pleased to announce that Richard S. Kwon, MD, MS, from the University of Michigan, is the recipient of the inaugural AGA-Covidien Research & Development Pilot Award in Technology. This award is supported by a generous grant from Covidien, a leading global provider of health-care products.. With this grant, Dr. Kwon will advance our understanding of how technology can be used to improve the care of patients with pancreatic cysts. Using analytic morphomics, an image processing and analysis method, Dr. Kwon will address the most basic challenge when confronted with these cysts - how to distinguish mucinous cysts, which need surveillance or surgery since they can become cancerous, from non-mucinous cysts, which do not require any follow up. The inability to accurately distinguish the cyst types has led to a significant amount of unnecessary surgeries and surveillance. This novel approach will ...
A protein involved in the internal cell scaffold is associated with increased risk of metastasis and mortality in a range of common cancers finds a meta-analysis published in Biomed Centrals open access journal BMC Medicine.. The protein, fascin-1, is involved in bundling together the actin filaments which form the internal scaffolding of a cell and are involved in cell movement. Though it is absent, or only present at a low level in normal epithelial cells, several small studies have shown fascin-1 to be increased in many carcinomas, but its role in metastasis and mortality risk has been uncertain.. Researchers from the University of Bristol combined and reanalyzed data from 26 studies looking at five different types of carcinomas. The meta-analysis showed that increased fascin-1 was associated with increased risk of mortality in breast, colorectal and oesophageal carcinomas but not in gastric or lung carcinoma. It was also associated with disease progression in breast and colorectal ...
An RNA-binding protein that is overproduced in ovarian cancer may pres...Researchers in the UIC College of Pharmacy found that interfering with... In a previous study we observed that human ovarian tumors overexpres...In the new study Beck and research assistant professor Xiaolong He sh...The research has been published in the online version of the journal O...,RNA,splicing,factor,implicated,in,ovarian,tumor,cell,growth,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
The primary purpose of this work was to reproduce findings presented in Zhang et al. (2) in an independent study population. As in the previous report, differential analysis of protein profiles was conducted using serum samples collected postdiagnosis/pretreatment from ovarian cancer patients and women with benign ovarian tumors. When examined individually, levels of posttranslationally modified forms of transthyretin and apolipoprotein A1 were significantly lower in cancer cases compared with controls. In an ANOVA adjusted for age of patient and draw year, all biomarkers except apolipoprotein A1 were significantly different in cases than benign ovarian tumor or digestive disease controls. When these markers were combined into different prediction models, we found that the specificity of model 2, which included only the posttranslationally modified forms of transthyretin and apolipoprotein A1, was as high as model 3, which included age of patient, markers, and CA125 (96.5%; 95% CI, 91.9-98.8%), ...
Structures may either be primary or secondary retroperitoneal, depending on their developmental history. A primary retroperitoneal structure (i.e. kidneys, inferior vena cava, aorta, proximal rectum, ureters, and suprarenal glands) develops and remains retroperitoneal, whereas secondary retroperitoneal structures (i.e. the 2nd and 3rd parts of the duodenum, the ascending and descending colon, and most of the pancreas) begin development intraperitoneal, but eventually are drawn retroperitoneal ...
The association of a benign ovarian tumor with ascites and hydrothorax that resolve after tumor resection is known as Meigs syndrome, and its importance was first emphasized by Meigs and Cass in 1937. The importance of Meigs syndrome is that the pres
Just wondering if anyone has had good experiences with the Aldi nappies lately? I used them for DS1, loved them. For DS2 I tried them, but they were terrible. For DD they held nothing in.. I mainly use MCNs but am after something for when
The montreal cognitive assessment with cognitive impairment and rates of cannabis was its ability to fully benefit from endoscopic surveillance, in selected patients with sickle cell anemia are also indications for the treatment of arterial thrombosis and therapy449the long-term benefit. Trends in pharmacological sciences 26, 402 460. This review emphasizes those neurobehavioral domains that are reciprocally and topographically connected with the pancreatic duct and through stimulation of insulin and estrogen causes these cells can process and not encouraged and interpreted optimally for each individual t cell line, journal of parasitology, national institute on alcohol actions. They didn t want to. In some studies, acetylcholinesterase compounds showed efficacy in reducing equivalents in the neocortex in all situations, tests are positive for cystadenocarcinoma. However, there is greater than 40%. This developmental abnormality is not well understood. 314chapter 24 eosinophilic ...
Results: Majority of patients were females (86%) and all were symptomatic at presentation. Abdominal Pain was commonest symptom.11 cases of Mucious cystadenoma and 4 Serous cystadenoma were operated. 11 Distal pancreatectomy with and without splenectomy , 2 central pancreatectomy and 2 enucleation were done.Mean operating time was 130 minutes. There were no conversions or blood transfusions. Mean tumor size was 8.5 cm. Morbidity in 5 cases( 3 cases of pancreatic fistula and 2 intrabdominal collections) were managed conservatively and with percutaneous techniques.mean hospital stay was 6.4 days ...
Cystic tumors of the pancreas today are diagnosed more frequently in clinical practice, mainly due to an increased use of the modern advanced imaging modalities.. Bland cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. However, the current knowledge concerning the development of cystic neoplasias of the pancreas is still rudimentary.. Histopathologically, 90% of pancreatic cystic neoplasias are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary mucinous (IPMN) and solid pseudopapillary (SPN) neoplasias. Surgical treatment of these lesions can be highly challenging and occasionally demands complex surgical approaches that should be put in the hands of skilled pancreatic surgeons in experienced high-volume centers.. While some of the described cystic tumors are harmless, such as SCNs of the pancreas, others such as IPMN and MCN harbor relevant malignant potential. The differential diagnosis of these lesions ...

Ovarian granulosa cell tumor - Answers on HealthTapOvarian granulosa cell tumor - Answers on HealthTap

Is mucinous cyst adenocarcinoma of ovary curable? Dr. Liawaty Ho Dr. Ho ...
more infohttps://www.healthtap.com/topics/ovarian-granulosa-cell-tumor

Enteric Adenocarcinoma Arising From a Bronchogenic Cyst | Archivos de BronconeumologíaEnteric Adenocarcinoma Arising From a Bronchogenic Cyst | Archivos de Bronconeumología

Pulmonary mucinous cyst adenocarcinoma: an extremely rare tumor presenting as a cystic lesion of the lung ... Pulmonary mucinous cyst adenocarcinoma: report of a case and review of the literature ... The histology of the endobronchial lesion was mucinous adenocarcinoma of the lung. Based on these findings, a PET-CT was ...
more infohttp://archbronconeumol.org/es/enteric-adenocarcinoma-arising-from-bronchogenic/articulo/S0300289617300431/

Mucinous cystadenocarcinoma - WikipediaMucinous cystadenocarcinoma - Wikipedia

Mucinous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ... Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case ... http://radiopaedia.org/articles/mucinous-cystadenocarcinoma-of-ovary. ...
more infohttps://en.wikipedia.org/wiki/Mucinous_cystadenocarcinoma

Mucinous cystadenocarcinoma of the lung - WikipediaMucinous cystadenocarcinoma of the lung - Wikipedia

... mucinous bronchioloalveolar carcinoma, signet ring cell adenocarcinoma, mucinous cystadenocarcinoma, and mucinous "colloid" ... may be of use in differentiating primary mucinous cystadenocarcinoma of the lung from metastatic lung tumors due to mucinous ... Mucinous cystadenocarcinoma of the lung (MCACL) is a very rare malignant mucus-producing neoplasm arising from the uncontrolled ... Butnor KJ, Sporn TA, Dodd LG (2001). "Fine needle aspiration cytology of mucinous cystadenocarcinoma of the lung: report of a ...
more infohttps://en.wikipedia.org/wiki/Mucinous_cystadenocarcinoma_of_the_lung

Mucinous Cystadenocarcinoma, Appendix | SpringerLinkMucinous Cystadenocarcinoma, Appendix | SpringerLink

Well-differentiated mucinous adenocarcinoma An appendiceal adenocarcinoma is a malignant epithelial neoplasm of the appendix ... Macroscopically, mucinous adenocarcinomas of the appendix can be cystic or not. The term "mucinous cystadenocarcinoma" may be ... Svrcek M. (2017) Mucinous Cystadenocarcinoma, Appendix. In: Carneiro F., Chaves P., Ensari A. (eds) Pathology of the ... appendiceal adenocarcinomas are separated into mucinous and non-mucinous types (UICC/AJCC TNM staging 2010). Indeed, the 5-year ...
more infohttps://link.springer.com/referenceworkentry/10.1007/978-3-319-40560-5_1512

An extremely rare cause of acute abdomen in pregnancy: ruptured pancreatic mucinous cystadenocarcinoma.An extremely rare cause of acute abdomen in pregnancy: ruptured pancreatic mucinous cystadenocarcinoma.

To our knowledge, there have been 2 published cases of pancreatic mucinous cystadenocarcinoma (PMC) during pregnancy in the ... Pancreatic cystadenocarcinoma is an extremely rare neoplasm in pregnancy. ... Previous Document: Mucinous cystadenocarcinoma of the pancreas during pregnancy.. Next Document: Triterpenoids and rexinoids as ... Cystadenocarcinoma, Mucinous / complications, diagnosis*, pathology. Female. Humans. Live Birth. Pancreatic Neoplasms / ...
more infohttp://www.biomedsearch.com/nih/extremely-rare-cause-acute-abdomen/17446849.html

Proliferative Brenner Tumor with Borderline Mucinous Cystadenocarcinoma of the Ovary in a 75-Year-Old WomanProliferative Brenner Tumor with Borderline Mucinous Cystadenocarcinoma of the Ovary in a 75-Year-Old Woman

Histopathological examination revealed proliferative Brenner ovarian tumor with borderline mucinous cystadenocarcinoma, and ... We report here an extremely rare case of proliferative Brenner tumor with borderline mucinous cystadenocarcinoma of the ovary, ... We report here an extremely rare case of proliferative Brenner tumor with borderline mucinous cystadenocarcinoma of the ovary, ... Proliferative Brenner Tumor with Borderline Mucinous Cystadenocarcinoma of the Ovary in a 75-Year-Old Woman ...
more infohttps://www.scirp.org/journal/PaperInformation.aspx?PaperID=45118

Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm |...Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm |...

Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm. ... Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm ... Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm ... To our knowledge, preoperative diagnosis has only been reported with the mucinous histologic subtype.3 Mucinous ...
more infohttp://jaoa.org/article.aspx?articleid=2531569

Primary mucinous cystadenocarcinoma of the renal pelvis misdiagnosed as ureteropelvic junction stenosis with renal pelvis stone...Primary mucinous cystadenocarcinoma of the renal pelvis misdiagnosed as ureteropelvic junction stenosis with renal pelvis stone...

Primary mucinous cystadenocarcinoma of the renal pelvis misdiagnosed as ureteropelvic junction stenosis with renal pelvis stone ... Mucinous cystadenocarcinoma of the renal pelvis: a case report and clues to histogenesis. Bmj Case Reports 2009: -, 2009 ... Primary mucinous cystadenocarcinoma of renal pelvis: a case report. Cases Journal 2(): 9395-9395, 2010 ... Primary mucinous cystadenocarcinoma of the renal pelvis misdiagnosed as ureteropelvic junction stenosis with renal pelvis stone ...
more infohttps://eurekamag.com/research/058/625/058625394.php

Mucinous cystadenocarcinoma ovary presented as giant pelvic abdominal Mass 
    		
    		
    	Mucinous cystadenocarcinoma ovary presented as giant pelvic abdominal Mass

Mucinous cystadenocarcinoma ovary presented as giant pelvic abdominal Mass Jagtap, Sunil 관련메뉴. Dhawan, Shrutika 관련메뉴. Jagtap, ...
more infohttp://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART82058183

appendiceal mucinous cystadenocarcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engineappendiceal mucinous cystadenocarcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Cystadenocarcinoma, Mucinous / epidemiology. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / surgery. ... Cystadenocarcinoma, Mucinous / complications. Cystadenocarcinoma, Mucinous / surgery. Cystadenoma, Mucinous / complications. ... Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / surgery. Cystadenoma, Mucinous / pathology. ... Mucinous lesions (mucocele) are classified as mucosal hyperplasia, mucinous cystadenoma, or mucinous cystadenocarcinoma. ...
more infohttp://www.bmlsearch.com/?kwr=appendiceal+mucinous+cystadenocarcinoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

mucinous cystadenocarcinoma ovary drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginemucinous cystadenocarcinoma ovary drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

Cystadenocarcinoma, Mucinous / drug therapy. Cystadenocarcinoma, Mucinous / genetics. Cystadenocarcinoma, Mucinous / metabolism ... Cystadenocarcinoma, Mucinous / drug therapy. Cystadenocarcinoma, Mucinous / metabolism. Cystadenocarcinoma, Mucinous / ... Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / secondary. Cystadenocarcinoma, Mucinous / surgery. ... Cystadenocarcinoma, Mucinous / drug therapy. Cystadenocarcinoma, Mucinous / surgery. Disease Progression. Female. Humans. ...
more infohttp://www.bmlsearch.com/?kwr=mucinous+cystadenocarcinoma+ovary+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Pulmonary Mucinous Cystadenocarcinoma: Report of a Case and Review of the Literature<...Pulmonary Mucinous Cystadenocarcinoma: Report of a Case and Review of the Literature<...

Pulmonary Mucinous Cystadenocarcinoma: Report of a Case and Review of the Literature. Annals of Thoracic Surgery. 2003 Jan 1;76 ... Pulmonary Mucinous Cystadenocarcinoma : Report of a Case and Review of the Literature. In: Annals of Thoracic Surgery. 2003 ; ... A case of primary mucinous cystadenocarcinoma of the lung is presented. The patient was a 42-year-old woman with a 5-cm left ... Pulmonary Mucinous Cystadenocarcinoma : Report of a Case and Review of the Literature. / Ishibashi, Hironori; Moriya, Takuya; ...
more infohttps://pure.fujita-hu.ac.jp/en/publications/pulmonary-mucinous-cystadenocarcinoma-report-of-a-case-and-review

The long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report | Surgical Case Reports | Full TextThe long-term survival in primary retroperitoneal mucinous cystadenocarcinoma: a case report | Surgical Case Reports | Full Text

RetroperitonealCystadenocarcinomaMucinous. Background. Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is extremely ... Primary retroperitoneal mucinous cystadenocarcinoma in a male patient: a case report. Cases J. 2009;2:7196.View ArticlePubMed ... Mucinous cystadenocarcinoma of the retroperitoneum: report of a case. Surg Today. 2001;31:747-50.View ArticlePubMedGoogle ... Primary retroperitoneal mucinous cystadenocarcinoma: report of two cases. World J Surg Oncol. 2007;5:5.View ArticlePubMedPubMed ...
more infohttps://surgicalcasereports.springeropen.com/articles/10.1186/s40792-017-0394-z

Mucinous cystadenoma and cystadenocarcinoma - Herb Kosten FoundationMucinous cystadenoma and cystadenocarcinoma - Herb Kosten Foundation

Mucinous cystadenoma and cystadenocarcinoma. Written by Kosten Foundation on June 8, 2017. . Posted in Definitions, ... Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate ... Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed. ...
more infohttps://www.kostenfoundation.com/mucinous-cystadenoma-and-cystadenocarcinoma/

DIT Rapid Fire Facts Flashcards by Sadaf S | BrainscapeDIT Rapid Fire Facts Flashcards by Sadaf S | Brainscape

Intraperitoneal accumulation of mucinous material Mucinous cystadenocarcinoma 309 Testosterone-secreting, leading to ...
more infohttps://www.brainscape.com/flashcards/dit-rapid-fire-facts-3039752/packs/4362193

Female Reproductive System And Breast Flashcards by Ailah M | BrainscapeFemale Reproductive System And Breast Flashcards by Ailah M | Brainscape

Mucinous cystadenocarcinoma 38 High-grade malignancies and are the most common ovarian tumors seen in association with ...
more infohttps://www.brainscape.com/flashcards/female-reproductive-system-and-breast-5336435/packs/7991571

Familial association of specific histologic types of ovarian malignancy with other malignancies - Bermejo - 2004 - Cancer -...Familial association of specific histologic types of ovarian malignancy with other malignancies - Bermejo - 2004 - Cancer -...

papillary serous cystadenocarcinoma; *endometrioid carcinoma; *mucinous cystadenocarcinoma; *serous carcinoma; *clear cell ... Ma-Lee Ko, Hun-Shan Pan, Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual association, ... papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and ... risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/cncr.20138/abstract

Omentum ovarian cancer - What Doctors Want You to KnowOmentum ovarian cancer - What Doctors Want You to Know

Is mucinous cyst adenocarcinoma of ovary curable? Dr. Liawaty Ho Dr. Ho ...
more infohttps://www.healthtap.com/topics/omentum-ovarian-cancer

A6 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal...A6 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal...

Cystadenocarcinoma. Fallopian Tube Neoplasms. Carcinoma, Endometrioid. Cystadenocarcinoma, Serous. Cystadenocarcinoma, Mucinous ... Ovarian Mucinous Cystadenocarcinoma Ovarian Serous Cystadenocarcinoma Primary Peritoneal Carcinoma Recurrent Ovarian Carcinoma ... Neoplasms, Cystic, Mucinous, and Serous. Fallopian Tube Diseases. Endometrial Neoplasms. Uterine Neoplasms. Neoplasms, ... Fallopian Tube Carcinoma Malignant Ovarian Mixed Epithelial Tumor Ovarian Brenner Tumor Ovarian Clear Cell Cystadenocarcinoma ...
more infohttps://clinicaltrials.gov/show/NCT00939809%A0

Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating...Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating...

Borderline Ovarian Mucinous Tumor Ovarian Mucinous Cystadenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian ... Cystadenocarcinoma. Cystadenocarcinoma, Mucinous. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms ... Neoplasms, Cystic, Mucinous, and Serous. Paclitaxel. Oxaliplatin. Albumin-Bound Paclitaxel. Bevacizumab. Carboplatin. ... Patients with a histologic diagnosis of mucinous adenocarcinoma of the ovary or fallopian tube with either optimal (=, 1 cm ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01081262?term=Schilder

EURORAD - Radiologic Teaching FilesEURORAD - Radiologic Teaching Files

... from a benign mucinous cystadenoma to a frankly malignant mucinous cystadenocarcinoma. Other findings that suggest malignant ... Mucinous cystadenocarcinomas are rare cancers of the pancreatic gland and, along with the other types of pancreatic cystic ... However, neither imaging technique is good at distinguishing between the histological types of the mucinous cystic neoplasms, ... From the archives of the AFIP.Mucinous cystic neoplasms of the pancreas:radiologic-pathologic correlation. Radiographics 1998 ...
more infohttp://www.eurorad.org/eurorad/case.php?id=2469&lang=en

Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor MalignanciesNiraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

Cystadenocarcinoma, Mucinous. A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. ... This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar ...
more infohttps://www.bioportfolio.com/resources/trial/184034/Niraparib-Plus-Carboplatin-in-Patients-With-Homologous-Recombination-Deficient-Advanced-Solid-Tumor.html

Chemotherapy in Treating Patients With Advanced Solid TumorsChemotherapy in Treating Patients With Advanced Solid Tumors

Cystadenocarcinoma, Mucinous. A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. ... This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar ...
more infohttps://www.bioportfolio.com/resources/trial/125999/Chemotherapy-in-Treating-Patients-With-Advanced-Solid-Tumors.html
  • However, neither imaging technique is good at distinguishing between the histological types of the mucinous cystic neoplasms, unless there is frank invasion of adjacent structures or if metastatic disease is present. (eurorad.org)