AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation Science
Cyproterone AcetateCyproteroneAndrogen AntagonistsEthinyl EstradiolHirsutismEstradiol CongenersPregnadienesTestosteroneChlormadinone AcetateDihydrotestosteroneTranssexualismAcne VulgarisOcimumAndrogensPuberty, PrecociousFlutamidePregnanesProgesterone CongenersCastrationProstateSeminal VesiclesPolycystic Ovary SyndromeReceptors, AndrogenGenitalia, MaleMetriboloneImidazolidinesContraceptives, Oral, CombinedBuserelinGoserelinMifepristoneEncyclopedias as TopicMedlinePlusPenile ErectionLibidoPenisEroticaErectile DysfunctionHypogonadismKallmann SyndromePuberty, DelayedOsteoporosisGonadotropinsDAX-1 Orphan Nuclear Receptor
Cyproterone Acetate
An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
Cyproterone
An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Androgen Antagonists
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
Ethinyl Estradiol
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
Hirsutism
A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.
Estradiol Congeners
Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
Pregnadienes
Pregnane derivatives containing two double bonds anywhere within the ring structures.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Chlormadinone Acetate
An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
Dihydrotestosterone
A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
Transsexualism
Severe gender dysphoria, coupled with a persistent desire for the physical characteristics and social roles that connote the opposite biological sex. (APA, DSM-IV, 1994)
Acne Vulgaris
A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
Ocimum
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Puberty, Precocious
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.
Flutamide
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Pregnanes
Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.
Progesterone Congeners
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
Castration
Surgical removal or artificial destruction of gonads.
Prostate
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Seminal Vesicles
A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Polycystic Ovary Syndrome
A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Receptors, Androgen
Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.
Genitalia, Male
The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).
Metribolone
A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Imidazolidines
Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.
Contraceptives, Oral, Combined
Fixed drug combinations administered orally for contraceptive purposes.
Buserelin
A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.
Goserelin
A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.
Mifepristone
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
MedlinePlus
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Penile Erection
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Libido
The psychic drive or energy associated with sexual instinct in the broad sense (pleasure and love-object seeking). It may also connote the psychic energy associated with instincts in general that motivate behavior.
Penis
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Erotica
Literary or artistic items having an erotic theme. It refers especially to books treating sexual love in a sensuous or voluptuous manner. (Webster, 3d ed)
Erectile Dysfunction
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Hypogonadism
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
Kallmann Syndrome
A genetically heterogeneous disorder caused by hypothalamic GNRH deficiency and OLFACTORY NERVE defects. It is characterized by congenital HYPOGONADOTROPIC HYPOGONADISM and ANOSMIA, possibly with additional midline defects. It can be transmitted as an X-linked (GENETIC DISEASES, X-LINKED), an autosomal dominant, or an autosomal recessive trait.
Puberty, Delayed
The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Gonadotropins
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
DAX-1 Orphan Nuclear Receptor
An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.

The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (1/63)

We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent.  (+info)

Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. (2/63)

Testosterone acts on cells through intracellular transcription-regulating androgen receptors (ARs). Here, we show that mouse IC-21 macrophages lack the classical AR yet exhibit specific nongenomic responses to testosterone. These manifest themselves as testosterone-induced rapid increase in intracellular free [Ca(2+)], which is due to release of Ca(2+) from intracellular Ca(2+) stores. This Ca(2+) mobilization is also inducible by plasma membrane-impermeable testosterone-BSA. It is not affected by the AR blockers cyproterone and flutamide, whereas it is completely inhibited by the phospholipase C inhibitor U-73122 and pertussis toxin. Binding sites for testosterone are detectable on the surface of intact IC-21 cells, which become selectively internalized independent on caveolae and clathrin-coated vesicles upon agonist stimulation. Internalization is dependent on temperature, ATP, cytoskeletal elements, phospholipase C, and G-proteins. Collectively, our data provide evidence for the existence of G-protein-coupled, agonist-sequestrable receptors for testosterone in plasma membranes, which initiate a transcription-independent signaling pathway of testosterone.  (+info)

Prostate cancer treated by anti-androgens: is sexual function preserved? EORTC Genitourinary Group. European Organization for Research and Treatment of Cancer. (3/63)

This paper reports on results of the EORTC protocol 30892, an open, prospective, randomized study of 310 patients with previously untreated metastatic prostate cancer with favourable prognostic factors who were treated by either flutamide (FLU) or cyproterone acetate (CPA) monotherapy. The final analysis with regard to the main end points, time to progression and survival are still pending. Final results related to the evaluation of sexual functioning prior to and under treatment are reported here. Of 310 randomized patients 294 were eligible for evaluation within this side study. The median age was 71 years (range 48-85). Potential risk factors related to age, general health and prostate cancer were evaluated. For evaluation of sexual functions a five-item questionnaire was used which was administered by the investigator. The protocol allowed time dependent observations at 3-monthly follow-up visits. Sexual functioning was dependent on age but not on prostate cancer-related parameters. Sexual functions at entry were similar within the two treatment groups, spontaneous (nightly) erections and sexual activity were seen in 43-51% and 29-35% of cases. Under treatment, sexual functions under FLU and CPA declined slowly with median times of 12.9 and 5.8 months versus 13.7 and 8.9 months respectively for spontaneous erections and sexual activity. Eventually, with an average observation time in excess of 2 years, loss of spontaneous erections and of sexual activity occurred in 80% versus 92% and in 78% versus 88% of men under FLU versus CPA treatment respectively. None of these differences reached statistical significance. Maintenance of potency under treatment with FLU as reported in the literature is not confirmed in this study. However, loss of sexual functions under monotherapy with both antiandrogens is slow and 10-20% of men retain sexual activity after 2-6 years of treatment. This observation can be exploited in new treatment schemes and is likely to lead to improved quality of life. The advantage of FLU in time and total preservation of sexual functions is statistically not significant and must be balanced against the side effects of FLU and other pure antiandrogens, which may exceed those of CPA especially with respect to gynaecomastia. Hepatic toxicity may limit the long-term use of both drugs.  (+info)

Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries. (4/63)

OBJECTIVES: While there are many suggested reasons for the marked gender bias in cardiovascular events, much of the available data indicate that circulating estrogens are cardioprotective. The possibility that endogenous androgens may be detrimental to the cardiovascular system has received relatively less attention. We investigated the short-term modulatory effects of various concentrations of testosterone on vascular function in isolated porcine coronary artery rings. RESULTS: The higher concentrations (> 1 microM) of testosterone relaxed U46619-contracted coronary artery rings in an endothelium-independent manner. This direct effect was insensitive to the testosterone receptor antagonists, flutamide and cyproterone acetate. Short-term exposure (20 min) to low levels of testosterone (1-100 nM), which were ineffective on their own on vascular function, significantly diminished relaxation to bradykinin and calcium ionophore A23187 but not those produced by levcromakalim and sodium nitroprusside. The inhibitory effect observed with 1 nM testosterone was only partially reversed by flutamide and cyproterone acetate and unaltered in the presence of actinomycin D and cycloheximide. CONCLUSIONS: These results demonstrate that acute treatment with testosterone, at concentrations that have no effect on their own, reduces vasorelaxation. Furthermore, they suggest that this modulatory action may be in part independent of the classical testosterone receptor since it was not completely sensitive to the anti-androgens and was not inhibited by the transcriptional and translational inhibitors. These findings support the postulation that testosterone may have unfavorable influences on vascular function.  (+info)

Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries. (5/63)

1. We investigated the effects of short-term exposure to physiological levels of 17beta-estradiol and testosterone on vasocontractile responses in porcine coronary artery rings. 2. Concentration-response curves to endothelin-1, 5-hydroxytryptamine, the thromboxane analogue U46619 and KCl were constructed in endothelium-intact and endothelium-disrupted artery rings. 3. Thirty minutes exposure to 17beta-estradiol (1 and 30 nM) significantly attenuated vasoconstriction to endothelin-1, 5-hydroxytryptamine and U46619. Conversely, the same concentrations of testosterone significantly potentiated responses elicited by these contractile agents. These inhibitory effects of 17beta-estradiol and enhancing actions of testosterone on contractions were endothelium-independent. KCl-mediated contractions were unaffected by the presence of either sex hormones. 4. The oestrogen receptor antagonists, tamoxifen (10 microM) and ICI 182,780 (10 microM), were unable to reverse the inhibitory influence 1 nM 17beta-estradiol had on the agonist-mediated contractile responses. Similarly, the androgen receptor antagonists, flutamide (10 microM) and cyproterone acetate (10 microM), failed to affect the potentiating activities of 1 nM testosterone. The alteration in vasoconstrictive responses observed following acute exposure to either 1 nM 17beta-estradiol and 1 nM testosterone were apparent even in the presence of the protein synthesis inhibitor cycloheximide (10 microM) and the transcription inhibitor actinomycin D (10 microM). 6. In conclusion, we report a unique type of sex hormone action on the coronary vasculature. These events occur at low nanomolar concentrations of 17beta-estradiol and testosterone, are insensitive to conventional sex hormone receptor antagonists, are not blocked by de novo protein synthesis inhibitors and have rapid time-courses that are uncharacteristic of classical genomic activities.  (+info)

Cyproterone acetate diminishes sexual activity in male rabbits. (6/63)

Cyproterone acetate (CA) was injected daily in eleven rabbits for 3 weeks at a dose of 20 mg/day, and for a further week at a dose of 40 mg/day. After 3 weeks of treatment, the ejaculation frequency was reduced but other measures of sexual behaviour were not significantly changed. There was no reduction in the fructose concentration of the semen, but the volume of the ejaculates decreased. The vesicular glands from the experimental animals showed histological changes typical of those occurring after castration. It was concluded that CA reduced the activity of at least one of the accessory sex glands as well as sexual behaviour. This lends support to the current hypothesis that the endocrine regulation of rabbit sexual behaviour differs from that of the rat.  (+info)

Effect of antihormones in amygdala-kindled seizures in rats. (7/63)

Tamoxifen (TXF; an antiestrogen), cyproterone acetate (CYP; an antiandrogen) and mifepristone (MIF; an antigestagen) did not affect kindling parameters (afterdischarge threshold, seizure severity, seizure duration and afterdischarge duration) in fully-kindled rats. TXF (50 mg/kg) and CYP (50 mg/kg), when combined with carbamazepine, or phenobarbital, both antiepileptics administered at their highest subprotective doses of 15 mg/kg, resulted in significant reduction of the seizure and afterdischarge durations, both in male and female rats. Additionally, the combination of carbamazepine and cyproterone markedly increased the afterdischarge threshold in fully-kindled rats of both genders. The interaction between antihormones and carbamazepine, or phenobarbital, was not reversed by the respective gonadal hormones (estradiol, progesterone, and testosterone), kainic acid, or strychnine. However, the TXF-, and CYP-induced effect on the action of carbamazepine was abolished by bicuculline, N-methyl-D-aspartic acid and aminophylline. The effect of TXF on the protective activity of phenobarbital was reversed by bicuculline and N-methyl-D-aspartic acid. Finally, the CYP-mediated effect on phenobarbital action was abolished by bicuculline and aminophylline. Neither TXF nor CYP altered free plasma levels and brain levels of carbamazepine or phenobarbital, so a pharmacokinetic interaction between antihormones and antiepileptic drugs is not probable. In view of the present data, it may be suggested that the protective activity of the antiestrogen and antiandrogen are mostly associated with the enhancement of GABA-ergic and purinergic transmission in the central nervous system. Also the augmentation of glutamatergic transmission, realized through NMDA receptors, may be involved in the mechanism of antiseizure action of TXF and CYP.  (+info)

The androgenic regulation of the activities of enzymes engaged in the synthesis of deoxyribonucleic acid in rat ventral prostate gland. (8/63)

The restoration of mitosis and growth of the prostate gland of castrated animals by androgens provides a favourable experimental system for studying the hormonal regulation of enzymes engaged in DNA replication. 2. Many DNA polymerase activities were identified in the prostate gland, but only a 9S form with a particular preference for denatured DNA as template was conspicuously enhanced by androgenic stimulation. 3. Thymidine kinase also provided a sensitive indicator of the hormonal regulation of DNA replication, and on electrophoretic criteria, one discrete form of the enzyme appeared precisely with the onset of mitoris. 4. Evidence is presented to support the view that DNA ligase activity is intimately associated in the process of DNA replication in the prostate gland. 5. A spectrum of deoxyribonuclease activities is present in the prostate gland, but only one form (pI7.0) can safely be said to be implicated in the process of DNA replication. 6. Androgenic stimulation of the prostate gland leads to the appearance of a component capable of denaturing or unwinding prostate DNA. This component is seemingly distinct from RNA or DNA polymerase activities on the basis of several distince physicochemical characteristics. 7. The conspicuous feature of all the changes in enzyme activities evoked by androgens in the prostate gland is their acute tissue- and steroid-specificity. Such changes could not be mimicked in liver or spleen and the regulatory role of androgens could not be simulated by other classes of steroid hormones. Particularly on the basis of studies with the anti-androgen cyproterone acetate, it is concluded that the changes are initially mediated by the androgen-receptor system and the high-affinity binding of 5alpha-dihydrotestosterone in the prostate gland. 8. The results are discussed in the context of the mechanism of action of androgens.  (+info)

Cyproterone acetate - definition of Cyproterone acetate by The Free DictionaryCyproterone acetate - definition of Cyproterone acetate by The Free Dictionary
Define Cyproterone acetate. Cyproterone acetate synonyms, Cyproterone acetate pronunciation, Cyproterone acetate translation, English dictionary definition of Cyproterone acetate. n. A synthetic steroid that inhibits the secretion of androgens. n an antiandrogen drug that suppresses testosterone in the body
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Cyproterone - WikipediaCyproterone - Wikipedia
Cyproterone (developmental code names SH-80881, SH-881) is a steroidal antiandrogen which was studied in the 1960s and 1970s but was never introduced for medical use. It is an analogue of cyproterone acetate (CPA), an antiandrogen, progestin, and antigonadotropin which was introduced instead and is widely used as a medication. Cyproterone and CPA were among the first antiandrogens to be developed. It is important to clarify that the term cyproterone is often used as a synonym and shorthand for cyproterone acetate, and when the term occurs, what is almost always being referred to is, confusingly, CPA and not actually cyproterone. Cyproterone itself, unlike CPA, was never introduced for medical use and hence is not available as a medication. Cyproterone is a potent antiandrogen, similarly to CPA. However, it has approximately three-fold lower potency as an antagonist of the androgen receptor (AR) relative to CPA. Like CPA, cyproterone is actually a weak partial agonist of the AR, and hence has the ...
https://en.wikipedia.org/wiki/Cyproterone
Increased Risk of Meningioma With Cyproterone Acetate Use - Medical AdviseIncreased Risk of Meningioma With Cyproterone Acetate Use - Medical Advise
New details confirm an increased risk of developing intracranial meningiomas after prolonged use of the hormonal product cyproterone acetate.. Cyproterone acetate is a synthetic progestogen and potent anti-androgen that has been used in the treatment of hirsutism, alopecia, early puberty, amenorrhea, acne, and prostate cancer, and has also been combined with an estrogen in hormone replacement therapy.. The new findings were published online today in the BMJ.. The primary analysis showed that among women using cyproterone acetate, the rate of meningiomas was 23.8 per 100,000 person years vs 4.5 per 100,000 in the control group. After adjusting for confounders, cyproterone acetate was associated with a sevenfold increased risk of meningioma.. These were young women - the mean age of participants was 29.4 years and more than 40% of the cohort were younger than 25 years. The initial prescriber was a gynecologist for more than half (56.7%) of the participants, and 31.6% of prescriptions could ...
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Prolonged High-Dose Cyproterone Acetate Use Linked to Risk for Meningioma - MDNewslineProlonged High-Dose Cyproterone Acetate Use Linked to Risk for Meningioma - MDNewsline
TUESDAY, Feb. 16, 2021 (HealthDay News) - High-dose cyproterone acetate is associated with meningiomas treated by surgery or radiotherapy, according to a study published online Feb. 3 in The BMJ.. Alain Weill, M.D., from the French National Health Insurance in Paris, and colleagues examined the risk for meningioma associated with high-dose cyproterone acetate in an observational cohort study involving 253,777 girls and women aged 7 to 70 years who initiated cyproterone acetate between 2007 and 2014.. The researchers identified 69 meningiomas among 139,222 exposed participants (cumulative dose of at least 3 g during the first six months) and 20 meningiomas in the control group (114,555 participants; cumulative dose of less than 3 g) that were treated by surgery or radiotherapy. In the two groups, the incidence of meningioma was 23.8 and 4.5 per 100,000 person-years, respectively (crude relative risk, 5.2; adjusted hazard ratio, 6.6). For a cumulative dose of cyproterone acetate of more than 60 g, ...
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Cyproterone Acetate CAS 427-51-0 Cyproterone acetate (abbreviated as CPA), also sold under brand names such as Androcur among others, is a synthetic, steroidal antiandrogen, progestin, and antigonadotropin.It is primarily used in the treatment of...
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Why buy Diane 35mg (Cyproterone Acetate and Ethyl Estradiol)?. Diane 35mg (Cyproterone Acetate and Ethyl Estradiol) is used to curing severe acne in women. This is prescribed when acne has not to get better with antibiotics. This is effective contraceptive oil. However, this is not mainly given for contraception. The anti-androgen of this medicine stimulates the growth of the hair. The hair usually grows in the face. Diane 35mg is available here for $12.01.. How does Diane 35mg (Cyproterone Acetate and Ethyl Estradiol) work?. Diane contains Cyproterone Acetate and Ethyl Estradiol as its active ingredients. It controls the overproduction of androgen in women that produces the condition alopecia. Cyproterone Acetate is a derivative of progestagen and an anti-androgen. It blocks the production of androgen by the ovaries. Ethyl Estradiol is a synthetic estrogen that works together by undoing the effects of too much androgen in the body. Ethyl Estradiol enhances the effects of Cyproterone by reducing ...
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cyproterone - Everything2.comcyproterone - Everything2.com
cyproterone: a synthetic, hormonal steroid substance, related to progesterone, which is potent as an antiandrogen. A variant form is cyproterone acetate...
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Cyproterone acetate - WikipediaCyproterone acetate - Wikipedia
Cyproterone acetate (abbreviated as CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills. It is formulated and used both alone and in combination with an estrogen and is available for use both by mouth and by injection into muscle. Common side effects of non-contraceptive (i.e., high) dosages of CPA in men include gynecomastia (breast development) and feminization in general and in both men and women include low sex hormone levels, reversible infertility, sexual dysfunction, mental symptoms like depression, fatigue, and irritability, vitamin B12 deficiency, and elevated liver enzymes. At very high dosages, cardiovascular side effects can occur. Rare but ...
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Cyproterone Acetate Summary Report | CureHunterCyproterone Acetate Summary Report | CureHunter
Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
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Cyproterone acetate - DrugBankCyproterone acetate - DrugBank
An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
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Cyproterone Acetate in Treating Hot Flashes Following Surgical or Chemical Castration for Prostate CancerCyproterone Acetate in Treating Hot Flashes Following Surgical or Chemical Castration for Prostate Cancer
RATIONALE: Cyproterone acetate may be effective treatment for hot flashes following surgical or chemical castration for prostate cancer. It is not yet k
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Cyproterone acetate is an antiandrogen drug used in the treatment of symptoms associated with an excess of androgens, including hirsutism, ovulation problems, and male pattern baldness in women. It is also used in the treatment of prostate cancer. It may increase the risk of thromboembolic events so the use of oral contraceptives which use this drug in combination with estrogen can bring an increased risk of blood clots.
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Pilot clinical trial of treatment with pioglitazone + metformin + flutamide versus Low-Dose Ethinyl Estradiol + cyproterone...Pilot clinical trial of treatment with pioglitazone + metformin + flutamide versus Low-Dose Ethinyl Estradiol + cyproterone...
This pilot study will investigate the effects of combined treatment with flutamide + metformin + pioglitazone versus ethinylestradiol/cyproterone for 12 months
http://adisinsight.springer.com/trials/700201490?error=cookies_not_supported&code=ee09d61a-0953-4f46-80a6-364edd95b049
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Cyproterone (Oral Route, Intramuscular Route) Proper Use - Mayo ClinicCyproterone (Oral Route, Intramuscular Route) Proper Use - Mayo Clinic
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.. ...
http://www.mayoclinic.org/drugs-supplements/cyproterone-oral-route-intramuscular-route/proper-use/drg-20067981?p=1
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Newcastle Hospitals - Prostate cancer long term hormone treatment and radiotherapy
Before starting radiotherapy you will start the hormone treatment. You will be given a prescription for Cyproterone acetate tablets (CPA) and Zoladex or Prostap injection. The CPA tablets are to be taken one week prior to your first hormone injection and for two weeks thereafter.. You must complete the course of CPA and they do not need to be continued by your GP.. Your first hormone injection will usually be given to you by the nurse practitioner in clinic however, it can be arranged for this to be administered by your GP or practice nurse at your GP surgery. It is given in the form of an injection that lasts for four weeks. After this your GP or practice nurse will give your injections once every 12 weeks.. These injections are given to stop the production of testosterone from the testicles. Prostate cancer needs testosterone to grow, so stopping its production will slow down the growth of the cancer cells.. You will need to continue on the injections for three monthsbefore the radiotherapy, ...
http://www.newcastle-hospitals.org.uk/services/19280.aspx
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After a control phase, 10 normal men received cyproterone acetate (CPA) at a dose of 25 mg/day (CPA-25; n=5) or 12.5 mg/day (CPA-12.5; n=5) plus testosterone enanthate (TE) 100 mg/week, for 16 weeks. Throughout the study sperm counts were performed every 2 weeks, and luteinizing hormone (LH ...
https://digital.lib.washington.edu/researchworks/handle/1773/3774/discover?field=subject&filtertype_0=subject&filtertype_1=subject&filtertype_2=subject&filter_relational_operator_1=equals&filter_relational_operator_0=equals&filter_2=Safety&filter_1=5-alpha+reductase+inhibitors&filter_relational_operator_2=equals&filter_0=colchicine&filtertype=subject&filter_relational_operator=equals&filter=Adult
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Dianette and Acne - InfoBarrel
Dianette, which is a name brand birth control pill, is also often prescribed to treat acne. Like other combined oral contraceptives, Dianette contains both an estrogen (ethinylestradiol )and progesterone (cyproterone acetate). The generic form, which contains the same active ingredients, is called Co-cyprindiol.
http://www.infobarrel.com/Dianette_and_Acne
Effects of Castration and Cyproterone Acetate On Some Biochemical Constituents of the Seminal Vesicle and/or Testis in the...Effects of Castration and Cyproterone Acetate On Some Biochemical Constituents of the Seminal Vesicle and/or Testis in the...
Castration of the catfish Heteropneustes fossilis for different duration (up to 4 weeks) in the preparatory-prespawning phase resulted in varied effects on plasma testosterone and seminal vesicle (SV) biochemical parameters in a duration-dependent manner. Although plasma testosterone was significantly reduced at all duration of castration in comparison to sham control values, a duration-dependent increase was noticed in the castrates after week 1. SV-somatic index (SVSI) increased significantly and steadily during castration except in week 1. Concentrations of total proteins decreased initially in week 1, and increased subsequently to the sham control level in week 2 and significantly above the sham control values in weeks 3 and 4. Hexosamine concentration was significantly low in weeks 1 and 2, and was restored in weeks 3 and 4. Fructose concentration decreased significantly in weeks 1, 2 and 3, and increased significantly in week 4. In contrast, glucose concentration increased significantly in week 1,
http://booksandjournals.brillonline.com/content/journals/10.1163/156854201x00044
Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17a-ethinylestradiol (EE2), and...Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17a-ethinylestradiol (EE2), and...
Synthetic progestins act as endocrine disrupters in fish but their risk to the environment is not sufficiently known. Here, we focused on an unexplored antiandrogenic progestin, chlormadinone acetate (CMA), and the antiandrogenic progestin cyproterone acetate (CPA). The aim was to evaluate whether their in vitro interaction with human and rainbowfish (Melanotaenia fluviatilis) sex hormone receptors is similar. Furthermore, we investigated their activity in zebrafish (Danio rerio) eleuthero-embryos. First, we studied agonistic and antagonistic activities of CMA, CPA, and 17α-ethinylestradiol (EE2), in recombinant yeast expressing either the human progesterone (PGR), androgen (AR), or estrogen receptor. The same compounds were also investigated in vitro in a stable transfection cell system expressing rainbowfish nuclear steroid receptors. For human receptors, both progestins exhibited progestogenic, androgenic and antiestrogenic activity with no antiandrogenic or estrogenic activity. In contrast, ...
https://irf.fhnw.ch/handle/11654/25909
Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death...
TY - JOUR. T1 - Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. AU - Chen, Linjie. AU - Wolff, Dennis W.. AU - Xie, Yan. AU - Lin, Ming Fong. AU - Tu, Yaping. N1 - Funding Information: We gratefully acknowledge Dr. Debra Schwinn at Duke University Medical Center and Dr. Xu Luo at University of Nebraska Medical Center for providing immortalized human prostate stromal cells and recombinant TRAIL, respectively. We also thank Lyudmila Batalkina and Dr. Greg Perry for their technical assistance. Funding This work was partially supported by Nebraska State LB595 Research Grant, US Department of Defense PCRP Grant W81XWH-13-1-0074, National Institutes of Health Grant 1R21CA193271 to Dr. Yaping Tu, and the National Institutes of Health (5P20GM103489). The funders had no role in the design of the study, data collection, analysis and interpretation or preparation of the manuscript. Publisher Copyright: © 2017 The ...
https://experts.nebraska.edu/en/publications/cyproterone-acetate-enhances-trail-induced-androgen-independent-p
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DMOZ - Health: Pharmacy: Drugs and Medications: C: Cyproterone: With Ethinyl Estradiol
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http://dmoztools.net/Health/Pharmacy/Drugs_and_Medications/C/Cyproterone/With_Ethinyl_Estradiol/
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Psychiatric aspects of the assessment and treatment of sex offenders | BJPsych AdvancesPsychiatric aspects of the assessment and treatment of sex offenders | BJPsych Advances
The use of oestrogens to reduce sexual drive in sex offenders dates from the 1940s, but the practice fell into disuse because of the frequency of side-effects, including thrombosis, nausea, breast enlargement, carcinomatous change and feminisation (Bowden, 1991). Oestrogens were replaced by cyproterone acetate in Britain, Europe and Canada, and by medroxyprogesterone acetate in the USA (where cyproterone is not available). Long-acting gonadotrophin-releasing hormone (GnRH) agonist analogues have been a more recent (and more expensive) addition to the drugs used to suppress libido.. Cyproterone acetate is a steroid analogue first synthesised in West Germany in 1961. It has anti-androgenic and progestogenic effects, reducing serum levels of testosterone, luteinising hormone and follicle-stimulating hormone, but increasing serum prolactin levels. It acts mainly by blocking testosterone receptors. The main uses of this drug are the reduction of sexual drive and, in higher dosage, the treatment of ...
http://apt.rcpsych.org/content/10/1/73.full
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Hirsutism - Liver Doctor
For women with moderate to severe facial hair, it is usually necessary to use drugs with a hormonal action that will either reduce the bodys production of male hormones and/or block the action of male hormones upon the hair follicles. These drugs are extremely effective and, under strict medical supervision, are safe. They need to be given for a long time and you need to feel that the improvement in your appearance warrants the expense and slight risk in taking this long term medication. One of the drugs that can be used is cyproterone acetate (Androcur) which is the most powerful anti-male hormone available and reverses hirsutism in 80 percent of women after nine to twelve months of use. It is usually given with the oral contraceptive pill, as it is important for women taking cyproterone acetate to avoid pregnancy because its anti-male hormone properties may stop the sexual development in a male foetus. In post-menopausal women, or women who have had a hysterectomy, pregnancy is not a ...
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J Clin Psychiatry/Irradiation Therapy Prevents Gynecomastia in Sex Offenders Treated With AntiandrogensJ Clin Psychiatry/Irradiation Therapy Prevents Gynecomastia in Sex Offenders Treated With Antiandrogens
Sir: The only therapy that has so far been shown to be effective in the treatment of male sex offenders is long-term administration of antiandrogens. Cyproterone acetate and medroxyprogesterone acetate are the most widely used substances in this context. Although this therapy seems to be an effective method in reducing the relapse rate in sex offenders, it has yet come to only limited use. The frequent development of gynecomastia, seen after long-term treatment with antiandrogens, is a probable hindrance to the more widespread use of this treatment strategy. ...
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EMA Reviews Meningioma Risk With Cyproterone Medicines :: Pink SheetEMA Reviews Meningioma Risk With Cyproterone Medicines :: Pink Sheet
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Even allowing that this is a rough list supported, in many cases, by only a single study (the researchers use the term grosso-moto to describe it), thats an impressive and daunting amount of potential impact. Messing with the immune system? Brain function? Risk for heart disease? HRT is not something to be trifled with.. For me, this article has capped a lot of reading Ive been doing about the effects of HRT. And I have learned one thing from it all: I would never, ever try to undertake HRT by myself, the way some in the transgender community have chosen to. Asian estrogens and black-market androgens may be out there, but just because theyre available doesnt mean theyre a smart choice. Ill wait until I can do it under the care of a trained professional whos aware of all these things and who knows how to monitor them.. As a side note: the clinic upon which many of the findings in the article were based uses cyproterone acetate (CA) as its antiandrogen of choice. Id never heard of any ...
http://blog.hudsonweb.net/2013/05/30/hrt-is-not-something-to-be-messed-with/
Evaluation of Endocrine-Distrupting Chemical Effects Across Multiple Levels of Biological Organization: Integration of...Evaluation of Endocrine-Distrupting Chemical Effects Across Multiple Levels of Biological Organization: Integration of...
The effects of in vivo administration o,p-DDT will be compared to those of a synthetic estrogen, diethylstilbestrol and the effects of o,p-DDE will be compared to those of an antiandrogen, cyproterone acetate (hypothesis 2). The effects of both DDT analogs will be compared to those of p,p-DDD which does not bind to either the ER or AR in croaker (hypothesis 2) and a DDT mixture which approximates the analog composition in fish samples collected from the Southern California Bight. Both male and females will be exposed to the model compounds throughout their life cycles to obtain a comprehensive understanding of how chemicals impair teleost reproduction (hypothesis 1) and which reproductive life cycle stage is the most sensitive (hypothesis 4). Indices of reproductive function such as gametogenesis, sex differentiation, hatching success and sperm motility, as well as indices of endocrine function such as steroid and gonadotropin secretion and receptor concentrations will be measured after ...
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/450
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https://freethoughtblogs.com/nataliereed/2012/04/09/natural-privilege/?replytocom=23232
Natural PrivilegeNatural Privilege
6mg micronized estradiol 17, sublingual. 5mg finasteride. 50mg cyproterone acetate. 75mg methadone (in tang solution). two inhalations salbutemol, every four hours as needed. Every day.. I depend on these medications. In literal senses as well as existential ones, I need them in order to survive. Who and what I am, as well as my continued existence, hinges on modern medicine. Had I been born a century or so earlier, I wouldnt have even survived past infancy in order to experience the nightmares of gender dysphoria and opiate dependence. And in the event of a zombie apocalypse, Im totally fucked. Unless I were to take to hunting female zombies and harvesting their ovaries.. Needless to say, the Naturalistic Fallacy ends up feeling a tad personal for me. Im a naturally unnatural Natalie.. Yesterday on twitter I came across a woman calling herself Yeats Infection who decided to chastise the decision trans people make to become dependent on the capitalist pharmaceutical industry for the rest ...
https://freethoughtblogs.com/nataliereed/2012/04/09/natural-privilege/?replytocom=23218
New technology for automated biological image acquisition has introduced the need • Derivatives of Procaspase-Activating...New technology for automated biological image acquisition has introduced the need • Derivatives of Procaspase-Activating...
New technology for automated biological image acquisition has introduced the need for effective biological image analysis methods. images of HeLa cells, stained with various organelle-specific fluorescent dyes. The dataset includes 10 probes for intracellular organelles and structures. HeLa cells were stained with dyes (DAPI, MitoTracker, and DiOC6), or antibodies (Giantin, GPP130, Lamp2, Nucleolin, TfR, Actin, and Tubulin). Automated identification of sub-cellular organelles is usually important when characterizing newly discovered genes or genes with unknown functions. It is possible to fluorescently tag the protein(s) produced by any given gene, and the ability to identify the organelle where the protein resides provides an important clue to its possible function. It is important to note Cyproterone acetate that human experts have trouble distinguishing Endosomes and Lysosomes, and they also find overlapping Golgi compartments exceedingly difficult to differentiate. 2.2. CHO [2] is usually a ...
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Buy Flutamide Online! Flutamide is only found in individuals that have used or taken this drug. It is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
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Medical Writings ေဆးပညာစာမ်ား: Sleep disorders မအိပ္ဘဲေန အသက္မရွည္ (၂)
အျခားဗမာေဆးေတြနဲ႔ Cyproterone ကိုလည္း ေလး-ငါးလၾကာ ေသာက္ၾကည့္ ဖူးပါတယ္။ ေနာက္ေတာ့ ဘာေဆးမွ မေသာက္ပဲ ၾကိဳးစားျပီး အိပ္ၾကည့္တာ အိပ္တဲ့အခါ အိပ္တယ္၊ မအိပ္တယ္အခါလည္း မအိပ္ဘူး။ အိပ္ရင္လည္း နွစ္ႏွစ္ျခိဳက္ျခိဳက္ မရွိဘူး။ နွစ္ရက္သံုးရက္ ဆက္တိုက္ နွစ္နာရီ သံုးနာရီေလာက္ပဲ အိပ္လို႔ရျပီးေတာ့ ေနာက္တစ္ေန႔မွာ ၅ နာရီေလာက္ အိပ္နိုင္တာ မ်ိဳးလည္း ရွိခဲ့တယ္။ မအိပ္နိုင္တာက ...
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CyproteroneCyproterone
... and CPA were among the first antiandrogens to be developed. It is important to clarify that the term cyproterone is ... Cyproterone itself, unlike CPA, was never introduced for medical use and hence is not available as a medication. Cyproterone is ... Cyproterone (6-chloro-17-hydroxy-1,2α-methylenepregna-4,6-diene-3,20-dione) and cyproterone acetate (17-acetoxy-6-chloro-1,2α- ... Cyproterone (6-chloro-17a-hydroxy-1a,2a-methylene-pregna-4,6-diene-3,20-dione) and cyproterone acetate have received ...
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Cyproterone acetateCyproterone acetate
The English and generic name of unacetylated cyproterone is cyproterone and this is its INN and BAN, while cyprotérone is the ... "Cyproterone acetate - Barr Laboratories - AdisInsight". Nguyen Y, Bradford J, Fischer G (February 2018). "Cyproterone acetate ... Estradiol valerate/cyproterone acetate Ethinylestradiol/cyproterone acetate Kuhl H (2005). "Pharmacology of estrogens and ... "Pharmacokinetics of cyproterone acetate and its main metabolite 15 beta-hydroxy-cyproterone acetate in young healthy women". ...
https://en.wikipedia.org/wiki/Cyproterone_acetate
Pharmacology of cyproterone acetatePharmacology of cyproterone acetate
Effect of cyproterone and cyproterone acetate". The Biochemical Journal. 132 (3): 465-74. doi:10.1042/bj1320465. PMC 1177610. ... Panesar NS, Herries DG, Stitch SR (1979). "Effects of cyproterone and cyproterone acetate on the adrenal gland in the rat: ... Broulik PD, Starka L (1975). "Corticosteroid-like effect of cyproterone and cyproterone acetate in mice". Experientia. 31 (11 ... "Isolation and identification of 15-beta-hydroxy cyproterone acetate as a new metabolite of cyproterone acetate in dog, monkey ...
https://en.wikipedia.org/wiki/Pharmacology_of_cyproterone_acetate
Side effects of cyproterone acetateSide effects of cyproterone acetate
"Hepatite sub-fulminante d'evolution mortelle a l'acetate de cyproterone" [Fatal subfulminant hepatitis caused by cyproterone ... Kim BH, Kim DJ, Sohn KM, Yang HN, Choi MJ, Lee CW, Choi KC (2009). "잠복간경변 환자에서 cyproterone acetate에 의해 발생한 전격간부전 1예" [A case of ... Cyproterone acetate added to castration has never been shown in any controlled study to prolong disease-free survival or ... Jeffcoate, W. J.; Matthews, R. W.; Edwards, C. R. W.; Field, L. H.; Besser, G. M. (1980). "The effect of cyproterone acetate on ...
https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate
Teva PharmaceuticalsTeva Pharmaceuticals
Teva also manufactures generic medications for use outside of the US; Cyproterone acetate and Moclobemide being two examples. ...
https://en.wikipedia.org/wiki/Teva_Pharmaceuticals
Pharmacodynamics of progesteronePharmacodynamics of progesterone
Neumann, F (1987). "Pharmacology and Clinical Uses of Cyproterone Acetate". In Furr, BJA; Wakeling, AE (eds.). Pharmacology and ... cyproterone acetate, medroxyprogesterone acetate), which do bind to the AR and have been associated with significant androgenic ... Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)]" [Bioavailability of ... Treatment of virilized women with intramuscular administration of cyproterone acetate]" [Efficacy of Intra muscularly Applied ...
https://en.wikipedia.org/wiki/Pharmacodynamics_of_progesterone
Chlormadinone acetateChlormadinone acetate
Similarly to cyproterone acetate (CPA), CMA shows a lower risk of hot flashes than gonadotropin-releasing hormone analogues ( ... Werner S, Kunz S, Beckurts T, Heidecke CD, Wolff T, Schwarz LR (December 1997). "Formation of DNA adducts by cyproterone ... Martelli A, Mattioli F, Ghia M, Mereto E, Brambilla G (May 1996). "Comparative study of DNA repair induced by cyproterone ... Rabe T, Feldmann K, Heinemann L, Runnebaum B (January 1996). "Cyproterone acetate: is it hepato- or genotoxic?". Drug Saf. 14 ( ...
https://en.wikipedia.org/wiki/Chlormadinone_acetate
HirsutismHirsutism
Cyproterone acetate: A dual antiandrogen and progestogen. In addition to single form, it is also available in some formulations ... It has been found to possess equivalent or greater effectiveness than spironolactone, cyproterone acetate, and finasteride in ... April 2008). "Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in ... Examples include birth control pills containing cyproterone acetate, chlormadinone acetate, drospirenone, and dienogest. ...
https://en.wikipedia.org/wiki/Hirsutism
Medical uses of bicalutamideMedical uses of bicalutamide
... cyproterone acetate, a synthetic progestagen with strong anti-androgen activity is commonly used. Cyproterone has been ... Cyproterone, however, is not authorized for sale in the United States for any condition and has been associated with liver ... Cyproterone acetate was one of the first steroidal antiandrogen clinically used but its side-effects, especially the ... Cyproterone [acetate] is widely used outside the United States as the primary testosterone blocker in transgender women. ...
https://en.wikipedia.org/wiki/Medical_uses_of_bicalutamide
AntiandrogenAntiandrogen
Cyproterone acetate was first studied clinically, to treat sexual deviance in men 1969: Cyproterone acetate was first studied ... Cyproterone acetate was developed subsequently to high-dose estrogen and is the only steroidal antiandrogen that has been ... Aside from cyproterone acetate and chlormadinone acetate, a few other progestins used in oral contraceptives and/or in ... The steroidal antiandrogen cyproterone acetate was discovered in 1961 and introduced in 1973 and is often described as the ...
https://en.wikipedia.org/wiki/Antiandrogen
Estradiol undecylateEstradiol undecylate
In this study, the cyproterone acetate group was changed from intramuscular injections to 100 mg/day oral cyproterone acetate. ... Cyproterone acetate was also used in combination with estrogen in the study. Estradiol undecylate has been used clinically at ... There were five deaths in total, three in the estradiol undecylate group and two in the cyproterone acetate group. Two of the ... Schröder FH (1996). "Cyproterone Acetate - Results of Clinical Trials and Indications for Use in Human Prostate Cancer". ...
https://en.wikipedia.org/wiki/Estradiol_undecylate
Progestogen (medication)Progestogen (medication)
Examples include cyproterone acetate and chlormadinone acetate. Certain progestins can be used at very high doses to increase ... In studies with high-dose cyproterone acetate specifically, the increase in VTE risk has ranged from 3- to 5-fold. The ... The extent to which the increase in breast cancer risk was related to estrogen versus cyproterone acetate is unknown. ... Seaman HE, Langley SE, Farmer RD, de Vries CS (June 2007). "Venous thromboembolism and cyproterone acetate in men with prostate ...
https://en.wikipedia.org/wiki/Progestogen_(medication)
List of EORTC trialsList of EORTC trials
1987). "Cyproterone acetate versus medroxyprogesterone acetate versus diethylstilbestrol in the treatment of prostate cancer: ... 1989). "EORTC protocol 30761: a randomized study of non-metastatic and metastatic prostatic cancer treated by cyproterone ... Robinson MR (1988). "EORTC protocol 30805: a phase III trial comparing orchidectomy versus orchidectomy and cyproterone acetate ... April 2004). "Metastatic prostate cancer treated by flutamide versus cyproterone acetate. Final analysis of the "European ...
https://en.wikipedia.org/wiki/List_of_EORTC_trials
Feminizing hormone therapyFeminizing hormone therapy
It is specifically used as an alternative to cyproterone acetate in the United States, where cyproterone acetate is not ... Cyproterone acetate is particularly associated with elevated prolactin levels, and discontinuation of cyproterone acetate ... Cyproterone acetate at a dosage of 5 to 10 mg/day has been found to lower testosterone levels in men by about 50 to 70%, while ... Cyproterone acetate also has a variety of other adverse effects, such as fatigue and weight gain, and risks, such as blood ...
https://en.wikipedia.org/wiki/Feminizing_hormone_therapy
Management of hair lossManagement of hair loss
There is tentative evidence for cyproterone acetate in women. In December 2012, topical application of IGF-1 in a liposomal ...
https://en.wikipedia.org/wiki/Management_of_hair_loss
Estradiol (medication)Estradiol (medication)
Estradiol valerate/cyproterone acetate (Femilar) was introduced for use as a birth control pill in Finland in 1993, but was ... Estradiol valerate is available with cyproterone acetate as Climen; with dienogest as Climodien and Qlaira; with norgestrel as ... Benperidol or butyrophenone and the antiandrogen cyproterone acetate also used. Chatz, T.L. (June 1972). "Recognizing and ...
https://en.wikipedia.org/wiki/Estradiol_(medication)
Effects of hormones on sexual motivationEffects of hormones on sexual motivation
Benperidol or butyrophenone and the antiandrogen cyproterone acetate also used. Simpson ER, Jones ME (2006). "Of mice and men: ... Neumann F, Kalmus J (1991). "Cyproterone acetate in the treatment of sexual disorders: pharmacological base and clinical ... and marked androgen receptor antagonism with high-dosage cyproterone acetate monotherapy causes profound sexual dysfunction in ...
https://en.wikipedia.org/wiki/Effects_of_hormones_on_sexual_motivation
Steroidal antiandrogenSteroidal antiandrogen
Development was discontinued in favor of cyproterone acetate, which showed only a low rate of gynecomastia in males. BOMT (Ro 7 ... Cyproterone (SH-80881, SH-881): A pure AR antagonist without progestogenic activity, showing robust progonadotropic activity ... Used as a means of chemical castration for sexual deviation in men, particularly in the United States where cyproterone acetate ... Cyproterone acetate (Androcur): A combined AR antagonist and progestogen/antigonadotropin. Also has weak glucocorticoid ...
https://en.wikipedia.org/wiki/Steroidal_antiandrogen
Side effects of bicalutamideSide effects of bicalutamide
Chen CS, Gao GL, Ho DR, Lin CY, Chou YT, Chen SC, Huang MC, Kao WY, Su JJ (March 2021). "Cyproterone acetate acts as a ... Kim JH, Yoo BW, Yang WJ (May 2014). "Hepatic failure induced by cyproterone acetate: A case report and literature review". Can ... 618-. ISBN 978-0-203-90912-6. Kim JH, Yoo BW, Yang WJ (May 2014). "Hepatic failure induced by cyproterone acetate: A case ... Savidou I, Deutsch M, Soultati AS, Koudouras D, Kafiri G, Dourakis SP (December 2006). "Hepatotoxicity induced by cyproterone ...
https://en.wikipedia.org/wiki/Side_effects_of_bicalutamide
Comparison of bicalutamide with other antiandrogensComparison of bicalutamide with other antiandrogens
Cyproterone acetate was one of the first steroidal antiandrogen clinically used but its side-effects, especially the ... SAAs include cyproterone acetate (CPA), megestrol acetate, chlormadinone acetate, and spironolactone. These drugs are steroids ... The only advantage of cyproterone acetate on pure antiandrogens seems to be the low incidence of hot flushes; [...] However, ... Barth JH, Cherry CA, Wojnarowska F, Dawber RP (July 1991). "Cyproterone acetate for severe hirsutism: results of a double-blind ...
https://en.wikipedia.org/wiki/Comparison_of_bicalutamide_with_other_antiandrogens
Drugs in pregnancyDrugs in pregnancy
Antiandrogenic drugs, including spironolactone and cyproterone acetate, should be avoided. If planning to conceive while using ...
https://en.wikipedia.org/wiki/Drugs_in_pregnancy
15β-Hydroxycyproterone acetate15β-Hydroxycyproterone acetate
Cyproterone acetate treatment of male hypersexual subjects and female rhesus monkeys did not reveal any signs of adrenal ... Cyproterone acetate and its metabolites gave no indication of any appreciable antiinflammatory effect in the adjuvant edema ... Bhargava AS, Kapp JF, Poggel HA, Heinick J, Nieuweboer B, Günzel P (1981). "Effect of cyproterone acetate and its metabolites ... 15β-Hydroxycyproterone acetate (15β-OH-CPA) is a steroidal antiandrogen and the major metabolite of cyproterone acetate (CPA). ...
https://en.wikipedia.org/wiki/15β-Hydroxycyproterone_acetate
BenorteroneBenorterone
The reasons for this are unclear, as other pure antiandrogens such as cyproterone (not cyproterone acetate) and flutamide do ... while progesterone-derived steroidal antiandrogens include examples like cyproterone and cyproterone acetate. Benorterone was ... Free cyproterone, on the other hand, proved to be without clinical value for reasons that cannot be discussed here. Thus we are ... In one study, the affinity of benorterone for the AR was found to be about 5-fold greater than that of cyproterone acetate in ...
https://en.wikipedia.org/wiki/Benorterone
FlutamideFlutamide
... has been found to be equal to slightly more potent than cyproterone acetate and substantially more potent than ... Flutamide has far lower affinity for the AR than do steroidal antiandrogens like spironolactone and cyproterone acetate, and it ... Hence, it is described as nonsteroidal in order to distinguish it from older steroidal antiandrogens such as cyproterone ... Because flutamide is a pure antiandrogen, unlike steroidal antiandrogens like cyproterone acetate and megestrol acetate (which ...
https://en.wikipedia.org/wiki/Flutamide
Discovery and development of antiandrogensDiscovery and development of antiandrogens
Cyproterone acetate was developed to overcome this problem. It is formed by adding an acetate group to cyproterone, see figure ... Cyproterone is a steroidal antiandrogen that competitively inhibits the binding of testosterone or DHT to AR. Cyproterone binds ... An acetate group was then added to cyproterone and created cyproterone acetate. In the 1970s, the antiandrogen flutamide was ... Cyproterone acetate displays high affinity for AR in rats which increases when the 1,2-methylene group is removed from the ...
https://en.wikipedia.org/wiki/Discovery_and_development_of_antiandrogens
Megestrol acetateMegestrol acetate
Poyet P, Labrie F (October 1985). "Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and ... Furthermore, unlike antiandrogens such as spironolactone and bicalutamide but similarly to cyproterone acetate, there is ... Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)]" [Bioavailability of ... cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, and nomegestrol acetate. MGA differs from ...
https://en.wikipedia.org/wiki/Megestrol_acetate
DiethylstilbestrolDiethylstilbestrol
However, the addition of an "extremely low" dosage of 0.1 mg/day DES to cyproterone acetate has been found to result in a ... ISBN 978-1-60761-471-5. Goldenberg SL, Bruchovsky N, Rennie PS, Coppin CM (December 1988). "The combination of cyproterone ... Goldenberg SL, Bruchovsky N, Gleave ME, Sullivan LD (June 1996). "Low-dose cyproterone acetate plus mini-dose ... Elimination of flare reaction by pretreatment with cyproterone acetate and low-dose diethylstilbestrol". Cancer. 72 (5): 1685- ...
https://en.wikipedia.org/wiki/Diethylstilbestrol
OrchiectomyOrchiectomy
Any androgen-blocking medications, such as spironolactone or cyproterone, are stopped, and estrogen hormones can be resumed at ... Some common testosterone-blocking medications that most use before undergoing orchiectomy are spironolactone and cyproterone. ... Cyproterone can cause side effects such as fatigue, low mood, and fulminant hepatitis. Orchiectomy allows individuals to stop ...
https://en.wikipedia.org/wiki/Orchiectomy
AllylestrenolAllylestrenol
Knuth UA, Hano R, Nieschlag E (November 1984). "Effect of flutamide or cyproterone acetate on pituitary and testicular hormones ... "Treatment of advanced prostatic cancer with parenteral cyproterone acetate: a phase III randomised trial". British Journal of ...
https://en.wikipedia.org/wiki/Allylestrenol
Pharmacology of bicalutamidePharmacology of bicalutamide
In relation to its selectivity for the AR, unlike steroidal antiandrogens (SAAs) such as cyproterone acetate (CPA) and ... Knuth UA, Hano R, Nieschlag E (November 1984). "Effect of flutamide or cyproterone acetate on pituitary and testicular hormones ... ISBN 978-1-60547-431-1. From a structural standpoint, antiandrogens are classified as steroidal, including cyproterone [acetate ...
https://en.wikipedia.org/wiki/Pharmacology_of_bicalutamide
cyproterone - Healthy.netcyproterone - Healthy.net
Posts about cyproterone written by What Doctors Dont Tell You ... Evidence is mounting that cyproterone, principally intended to ...
https://healthy.net/tag/cyproterone/
Cyproterone : risk of meningiomasCyproterone : risk of meningiomas
Unknown author (‎2009)‎. Cyproterone : risk of meningiomas. https://extranet.who.int/iris/restricted/handle/10665/74474 ...
https://extranet.who.int/iris/restricted/handle/10665/74474
Cyproterone Tablet- Side effect(s)Cyproterone Tablet- Side effect(s)
Read the side effects of Cyproterone Tablet as described in the medical literature. In case of any doubt consult your doctor or ... Drug Name : Cyproterone Tablet. Cyproterone Tablet(Androcur) generic is an antiandrogen, prescribed for prostate cancer, benign ... Read the side effects of Cyproterone Tablet as described in the medical literature. In case of any doubt consult your doctor or ...
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CYPROTERONE ACETATE/ETHINYLESTRADIOL TABLETS 2MG/0.035MG | Drugs.comCYPROTERONE ACETATE/ETHINYLESTRADIOL TABLETS 2MG/0.035MG | Drugs.com
Patient information for CYPROTERONE ACETATE/ETHINYLESTRADIOL TABLETS 2MG/0.035MG Including dosage instructions and possible ... What Cyproterone Acetate / Ethinylestradiol is and what it is used for. 2.. What you need to know before you take Cyproterone ... How to store Cyproterone Acetate / Ethinylestradiol. 6.. Contents of the pack and other information. 1. What Cyproterone ... Cyproterone Acetate/Ethinylestradiol)..  If you have ever had liver tumours.  If you are allergic to cyproterone acetate, ...
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Thông tin thuốc của Cyproterone + Ethinylestradiol | MIMS VietnamThông tin thuốc của Cyproterone + Ethinylestradiol | MIMS Vietnam
Cyproterone + Ethinylestradiol: Belongs to the class of antiandrogen preparations in combination with estrogens. Used to ... Cyproterone acetate. Source: National Center for Biotechnology Information. PubChem Database. Cyproterone acetate, CID=9880, ... Cyproterone 2 mg and ethinylestradiol 0.035 mg tab For women with moderate to severe androgen-dependent acne and/or hirsutism ... Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Cyproterone + ...
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Cyproterone
Literature References: Prepn of free alcohol: Wiechert, Neumann, DE 1189991 C.A. 63, 1842e (1965); Wiechert, US 3234093 (1965, 1966 both to Schering AG). Biodynamics in man: Gerhards et al., Arzneim.-Forsch. 23, 1550 (1973). The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Effect on hormone secretion and on spermatogenesis in man: L. Moltz et al., Contraception 21, 393 (1980). Review of pharmacology and clinical studies (acetate) on acne and hirsutism in women: J. Hammerstein et al., J. Steroid Biochem. 19, 591 (1983). ...
https://www.drugfuture.com/chemdata/Cyproterone.html
The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne...The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne...
Doris and his colleagues concluded from this study that topical cyproterone acetate was equally effective as oral cyproterone ... All patients were female and were allocated to receive liposomal cyproterone acetate, placebo or oral cyproterone acetate. They ... The serum level of topical cyproterone acetate was 10 percent of oral cyproterone acetate [8]. ... Topical cyproterone acetate treatment in women with acne: a placebo-controlled trial. Arch Dermatol. 1998 Apr;134(4):459-63. 9 ...
https://dermatology.cdlib.org/uc/item/4zj6n2w3
Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p-DDE on the reproductive organs of the copepod...Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p'-DDE on the reproductive organs of the copepod...
Dive into the research topics of Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p-DDE on the ... Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p-DDE on the reproductive organs of the copepod ... Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p-DDE on the reproductive organs of the copepod ... title = "Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p-DDE on the reproductive organs of the ...
https://orbit.dtu.dk/en/publications/effects-of-anti-androgens-cyproterone-acetate-linuron-vinclozolin
Cyproterone Acetate (CAS 427-51-0) Market Size, Share, Outlook, Trend And ForecastCyproterone Acetate (CAS 427-51-0) Market Size, Share, Outlook, Trend And Forecast
Cyproterone Acetate (CAS 427-51-0) Market is anticipated to grow a faster pace with substantial growth rates in the forecasted ... Global Cyproterone Acetate (CAS 427-51-0) Market. Cyproterone Acetate Tablets , Ethinylestradiol Cyproterone Tablets , Others. ... Global Cyproterone Acetate (CAS 427-51-0) Market, By Product. • Cyproterone Acetate Tablets. • Ethinylestradiol Cyproterone ... 5. Global Cyproterone Acetate (CAS 427-51-0) Market, By Product. • Cyproterone Acetate Tablets. • Ethinylestradiol Cyproterone ...
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Androgen Excess Medication: Oral contraceptives, Antiandrogens, Aldosterone Antagonists, Selective, 5-Alpha-Reductase...Androgen Excess Medication: Oral contraceptives, Antiandrogens, Aldosterone Antagonists, Selective, 5-Alpha-Reductase...
Cyproterone acetate is an antiandrogen as well as a progestin. In one systematic review, cyproterone acetate (2 mg) was more ... 93] It is also available in an OC pill as cyproterone acetate (2 mg) with 35 u ethinyl estradiol, which has been shown to be ... Cyproterone acetate. Powerful antiandrogen usually administered with estrogens to maintain regular menstruation and to prevent ... Cyproterone acetate for hirsutism. Cochrane Database Syst Rev. 2003. CD001125. [QxMD MEDLINE Link]. ...
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cyproterone acetate. Definition / meaning of cyproterone acetate. The acetate salt of a synthetic steroidal antiandrogen with ... Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and ... Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. ...
https://www.medicalterminologydb.com/cyproterone-acetate
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Drugs that may cause erection problems: MedlinePlus Medical EncyclopediaDrugs that may cause erection problems: MedlinePlus Medical Encyclopedia
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Estradiol Valerate Philippines, Estradiol valerate cyproterone. Estradiol Valerate Philippines, Estradiol valerate cyproterone ... Reply To: Estradiol Valerate Philippines, Estradiol valerate cyproterone. Your information:. Name (required):. ... Estradiol Valerate Philippines, Estradiol valerate cyproterone acetate. Many families choose our online drugstore. Be one of ...
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Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results<...Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results<...
Schröder F. Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results. In ... Schröder, F 2001, Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results. ... Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results. / Schröder, Fritz. ... Metastatic prostate cancer - a randomized study of cyproterone acetate versus flutamide: summary of results. Renal, bladder, ...
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Ethinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg TabletEthinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg Tablet
Cyproterone acetate (GINETTE-35) 0.035mg+2mg tablet is a combination medication containing the following... ... Overdose of Ethinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg Tablet. If you took Ethinyl Estradiol + Cyproterone ... Dosage of Ethinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg Tablet. Adult: Acne, Hirsutism and Oral contraception: ... SKU: Ethinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg Tablet Category: Acne Medications Tag: Acne ...
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Neoadjuvant GnRH-agonist treatment (triptorelin and cyproterone acetate for flare protection) and total prostatectomy. Eur Urol ... of whom 112 were treated with 12 weeks of cyproterone acetate 300 mg daily prior to surgical therapy. In the NADT group, the ... Neoadjuvant hormone treatment with leuprolide acetate depot 3.75 mg and cyproterone acetate, before radical prostatectomy: a ... with localized prostate cancer to receive either leuprolide acetate depot 3.75 mg once a month for 3 months and cyproterone ...
https://emedicine.medscape.com/article/455994-overview
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Cysvia 35 Tablet Cyproterone (2mg) + Ethinyl Estradiol (0.035mg), By Osiante BiotechCysvia 35 Tablet Cyproterone (2mg) + Ethinyl Estradiol (0.035mg), By Osiante Biotech
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Prothrombotic changes in users of combined oral contraceptives containing drospirenone and cyproterone acetate
5 Vasilakis-Scaramozza C, Jick H. Risk of venous thromboembolism with cyproterone or levonorgestrel contraceptives. Lancet 2001 ... Prothrombotic changes in users of combined oral contraceptives containing drospirenone and cyproterone acetate. J Thromb ... Prothrombotic changes in users of combined oral contraceptives containing drospirenone and cyproterone acetate. develop ... a increased risk of thrombosis for users of OC containing previously unreported history of high blood pressure or cyproterone ...
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PDF) Viola rupestris F. W. Schmidt - Additamenta ad floram Reipublicae Bohemicae. XIII. - Zprávy Čes. Bot. Společ. 50/1: 124...PDF) Viola rupestris F. W. Schmidt - Additamenta ad floram Reipublicae Bohemicae. XIII. - Zprávy Čes. Bot. Společ. 50/1: 124...
Cyproterone was isolated from plasma by liquid-liquid extraction and the recovery was about 90% for plasma. The inter-day and ... Determination of cyproterone acetate in plasma samples by high-performance liquid chromatography. July 2003 · Bollettino ... A rapid and sensitive high-performance liquid chromatographic method for the determination of cyproterone acetate in human ... cyproterone acetate in plasma was 10 ng/ml. The calibration curve was linear over the concentration range 50-160. 0 ng/ml. ...
https://www.researchgate.net/publication/329886422_Viola_rupestris_F_W_Schmidt_-_Additamenta_ad_floram_Reipublicae_Bohemicae_XIII_-_Zpravy_Ces_Bot_Spolec_501_124-126
Ethinyl Estradiol0.035 mgETHINYLESTRADIOL TABLETSCalled Cyproterone acetateSpironolactoneTabletsAntiandrogenProgestationalTabletEstrogenAntiandrogensDrospirenoneBlood clotProgesteroneHirsutismAndrogenLotionOralTestosteroneSteroidsTreatmentAcneContraceptiveWomenPillsRiskProductWorksStudyHumanWeeks
Ethinyl Estradiol9
  • If you took Ethinyl Estradiol + Cyproterone acetate more than the usual dose, please seek medical help immediately. (ibuysildenafil.com)
  • Drug: Ethinyl Estradiol + Cyproterone acetate. (montezumacountyrepublicans.com)
  • Ethinyl Estradiol (0.035mg) + Cyproterone acetate (2mg), coated tablets. (montezumacountyrepublicans.com)
  • Taj Ster CYPROTERONE ACETATE/ETHINYLESTRADIOL TABLETS 2MG/0.035 Cyproterone acetate-ethinyl estradiol raises the levels of sex hormone-binding globulin by 300%-400% compared with a 50% increase caused by levonorgestrel preparations, which are known to have the lowest risk of thrombosis. (montezumacountyrepublicans.com)
  • Offering you a complete choice of products which include cyproterone acetate and ethinyl estradiol tablet, imiquad cream and 0.1% tacrolimus ointment. (chinmayisales.com)
  • Cyproterone acetate-ethinyl estradiol treatment alters urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women. (nel.edu)
  • Luboshitzky R, Herer P, Shen-Orr Z. Cyproterone acetate-ethinyl estradiol treatment alters urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women. (nel.edu)
  • Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was given to 20 male-to-female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. (vu.nl)
  • The comparison of the effectiveness and safety of drospirone ethinyl estradiol and ethinyl estradiol cyproterone in the treatment of polycystic ovarian syndrome: A protocol for systematic review and meta-analysis. (cdc.gov)
0.035 mg2
  • Ginette-35 contains 2 mg of cyproterone acetate, and 0.035 mg of ethinylestradiol per pill. (theswisspharmacy.com)
  • The active pharmaceutical ingredients contained in Ginette contraceptive pills are 2 mg cyproterone acetate, and 0.035 mg ethinylestradiol. (theswisspharmacy.com)
ETHINYLESTRADIOL TABLETS1
Called Cyproterone acetate1
  • Estelle™-35/35 ED contains two types of sex hormones, a progestogen called Cyproterone acetate and an estrogen called Ethinylestradiol. (montezumacountyrepublicans.com)
Spironolactone1
  • Drugs that may interrupt testicular function - Including agents that interfere with testosterone synthesis, such as spironolactone and cyproterone. (medscape.com)
Tablets1
  • Before using Ginette-35 contraceptive tablets please consult a physician, inform about all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies, and get tested for any possible allergies to cyproterone acetate, or ethinylestradiol. (theswisspharmacy.com)
Antiandrogen1
  • Ethinylestradiol/cyproterone acetate, also known as co-cyprindiol and sold under the brand names Diane and Diane-35 among others, is a combination of ethinylestradiol, an estrogen, and cyproterone acetate, a progestin and antiandrogen, which is used as a birth control pill to prevent pregnancy in women. (montezumacountyrepublicans.com)
Progestational1
  • An anti-androgen that, in the form of its acetate ( CYPROTERONE ACETATE ), also has progestational properties. (bvsalud.org)
Tablet3
  • Read the side effects of Cyproterone Tablet as described in the medical literature. (medindia.net)
  • Offering you a complete choice of products which include cyproterone acetate, celkeran 2 mg tablet, geftib tablet, soranib tablet, sorafenib tablet and abirapro. (medsure.in)
  • Ethinylestradiol+Cyproterone acetate (GINETTE-35) 0.035mg+2mg tablet is a combination medication containing the following: Cyproterone acetate, a progesterone, and Ethinylestradiol, an estrogen. (ibuysildenafil.com)
Estrogen1
  • Also of interest, the addition of the native estrogen, 17beta-estradiol, or the antiandrogens, cyproterone acetate (1-1000 nM) or hydroxyflutamide (1-1000 nM), had no effect on basal or hCG-stimulated T following exposure for 24 h, suggesting that the actions of HPTE are not due to its estrogenic or antiandrogenic properties. (cdc.gov)
Antiandrogens1
  • One of the suggested treatments for acne vulgaris is use of antiandrogens, including oral cyproterone acetate, that can decrease lipid secretion from the sebaceous glands. (cdlib.org)
Drospirenone1
  • The risk of developing a blood clot associated with cyproterone use is considered to be 1.5 to 2 times higher than for CHCs containing levonorgestrel and may be similar to the risk with contraceptives containing gestodene, desogestrel or drospirenone. (tga.gov.au)
Blood clot1
  • Taking Cyproterone Acetate / Ethinylestradiol may slightly increase your risk of having a blood clot (called a thrombosis), especially in the first year of taking it. (drugs.com)
Progesterone1
  • Cyproterone acetate is an artificial derivative of 17-Hydroxyprogetrone which acts as an androgen receptor antagonist, and also weakly inhibits progesterone receptors. (theswisspharmacy.com)
Hirsutism1
  • While cyproterone is indicated for the treatment of moderate to severe acne related to androgen sensitivity and/or hirsutism, it is known to have efficacy as a contraceptive. (tga.gov.au)
Androgen2
  • Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. (medicalterminologydb.com)
  • Cyproterone acetate and ethylestradiol also inhibit androgen receptors, thus helping to maintain the normal male androgen levels in the female body. (theswisspharmacy.com)
Lotion3
  • In this study we evaluated the efficacy of cyproterone acetate alcohol lotion (CAAL) in the treatment of the mild to moderate acne vulgaris. (cdlib.org)
  • Regarding the results of this study, we suggest the use of cyproterone acetate alcohol lotion as one of the main treatments for mild-moderate acne in female patients and as an adjuvant treatment for moderate to severe acne vulgaris. (cdlib.org)
  • Regarding the price and difficulty in preparation of microsomal lotion of cyproterone acetate, we conducted a study to evaluate the efficacy of alcoholic lotion of cyproterone acetate for treatment of the mild to moderate acne vulgaris in females. (cdlib.org)
Oral4
  • Cyproterone Acetate / Ethinylestradiol also works as an oral contraceptive. (drugs.com)
  • It is shown that oral cyproterone acetate significantly reduces the sebum excretion. (cdlib.org)
  • Unfortunately, oral cyproterone acetate has many side effects including fatigue, spontaneous milk secretion, development of the benign breast nodules, weight gain, and rarely anemia [ 7 ]. (cdlib.org)
  • The risk of venous thromboembolism was later also found to be increased for use of oral contraceptives containing cyproterone. (bmj.com)
Testosterone1
  • Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. (medicalterminologydb.com)
Steroids2
  • Also for women taking cyproterone acetate for menopause (or women who don't want to use DNP) Fellowship has more info on this in their post about how to use a suppository, steroids trustpilot. (cisnerosdesign.com)
  • This steroid also has the advantage of having no side effects such as diarrhea, weight gain, diarrhea or other symptoms for many years and is great as an alternative and cheap alternative than other anabolic steroids that are more commonly seen in the medical profession, like the long-lasting steroids nandrolone, cyproterone acetate and drostanolone. (finepiece.global)
Treatment1
  • Application of topical microsomal form of cyproterone acetate has been suggested for treatment of this condition [ 8 ]. (cdlib.org)
Acne2
  • 1. What Cyproterone Acetate / Ethinylestradiol is and what it is used for Cyproterone Acetate / Ethinylestradiol is used to treat skin conditions such as acne, very oily skin and excessive hair growth in women of reproductive age. (drugs.com)
  • You should only take Cyproterone Acetate / Ethinylestradiol if your skin condition has not improved after use of other anti-acne treatments, including topical treatments and antibiotics. (drugs.com)
Contraceptive1
  • Ginette-35 contraceptive pill contains two pharmaceutical ingredients, cyproterone acetate, and ethinylestradiol. (theswisspharmacy.com)
Women2
  • Cyproterone Acetate / Ethinylestradiol is suitable for most healthy women it isn't suitable for everyone. (drugs.com)
  • Cyproterone and ethinylestradiol treat the signs of androgenisation in women through different but complementary mechanisms. (mims.com)
Pills1
Risk1
  • Talk to your doctor or pharmacist before taking Cyproterone Acetate / Ethinylestradiol or if you have any of the illnesses or risk factors mentioned in this leaflet. (drugs.com)
Product1
  • The market analysis entails a section solely dedicated for major players in the Global Cyproterone Acetate (CAS 427-51-0) Market wherein our analysts provide an insight to the financial statements of all the major players along with its key developments product benchmarking and SWOT analysis. (marketresearchintellect.com)
Works1
  • Cyproterone acetate works synergistically with ethinylestradiol to prevent pregnancy by disallowing ripening of eggs in the ovaries, and by stopping ovulation. (theswisspharmacy.com)
Study1
  • The Global Cyproterone Acetate (CAS 427-51-0) Market study provides an outlook on the development of market in terms of revenue throughout the prognosis period. (marketresearchintellect.com)
Human1
  • A rapid and sensitive high-performance liquid chromatographic method for the determination of cyproterone acetate in human plasma has been developed. (researchgate.net)
Weeks2
  • You may need to stop taking Cyproterone Acetate / Ethinylestradiol about 4-6 weeks before the operation. (drugs.com)
  • RU 58841, RU 56187, RU 38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear pinna of sexually mature male Syrian hamsters. (regrowth.com)
Cyproterone - Healthy.net
Cyproterone - Healthy.net (healthy.net)
Drugs that may cause erection problems: MedlinePlus Medical Encyclopedia
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Cyproterone : risk of meningiomas
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Fixed Drug Eruptions Treatment & Management: Medical Care, Consultations, Diet
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Neoadjuvant Androgen Deprivation Therapy in Prostate Cancer: Overview, Androgen Deprivation, Selection of Candidates for NADT
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PDF) Viola rupestris F. W. Schmidt - Additamenta ad floram Reipublicae Bohemicae. XIII. - Zprávy Čes. Bot. Společ. 50/1: 124...
PDF) Viola rupestris F. W. Schmidt - Additamenta ad floram Reipublicae Bohemicae. XIII. - Zprávy Čes. Bot. Společ. 50/1: 124... (researchgate.net)
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Infertility | Reproductive Health | CDC
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Hypogonadism: Practice Essentials, Background, Pathophysiology
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Risk of Meningioma With Cyproterone: EMA Review Begins
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Increased Risk of Meningioma With Cyproterone Acetate Use
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