A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
Agents that are used to stimulate appetite. These drugs are frequently used to treat anorexia associated with cancer and AIDS.
Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.
A pharmacologic congener of serotonin that contracts smooth muscle and has actions similar to those of tricyclic antidepressants. It has been proposed as an oxytocic.
The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.
Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.
Prejudice or discrimination based on gender or behavior or attitudes that foster stereotyped social roles based on gender.
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Directions written for the obtaining and use of DRUGS.
Injections made into a vein for therapeutic or experimental purposes.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)
The giving of drugs, chemicals, or other substances by mouth.
Hard or soft soluble containers used for the oral administration of medicine.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)

Inhibitory effects of cyproheptadine on pituitary-thyroid axis and pancreatic beta cells in rats. (1/134)

AIM: To study the influences of cyproheptadine (Cyp) on the endocrine functions of pituitary-thyroid axis and pancreatic beta cells in rats. METHODS: The effects of Cyp on functions of pituitary-thyroid axis and pancreatic beta cells were observed by radioimmunoassay, biochemical analysis, and electron microscope. RESULTS: Cyp 2.3 mg.kg-1 ig for 10 d decreased serum thyroid stimulating hormone (TSH) from control groups (5.3 +/- 0.9) to (4.2 +/- 0.9) mU.L-1 and insulin levels from (64 +/- 8) to (50 +/- 9) kIU.L-1 (P < 0.05 and 0.01). Cyp 4.6 mg.kg-1 decreased serum TSH (3.8 +/- 0.5) mU.L-1, T3 (1.2 +/- 0.2) mmol.L-1, T4 (62 +/- 7) mmol.L-1, and insulin levels (42 +/- 8) kIU.L-1 decreased (P < 0.05 or 0.01). The retrograde changes of ultrastructure of pituitary TSH cells and pancreatic beta cells. CONCLUSION: Cyp has an inhibiting action on endocrine functions of pituitary-thyroid axis and pancreatic beta cells in rats.  (+info)

Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone on TNF alpha production in endotoxic shock. (2/134)

AIM: To study the effects of dexamethasone (Dex), cyproheptadine (Cyp), anisodamine (Ani), and dinoprostone (Din) on lipopolysaccharides (LPS)-induced tumor necrosis factor alpha (TNF alpha) gene expression and antishock effects of inhibiting TNF alpha production. METHODS: Endotoxic shock in rats was produced by i.v. injection of LPS (E coli O111B4, 5 mg.kg-1). TNF alpha mRNA accumulation was assessed by Northern blot. Plasma TNF alpha contents were determined by radioimmunoassay. RESULTS: The TNF alpha mRNA levels in rat liver at 2 h after LPS challenge was increased obviously (autoradiograms analyzed by scanning were 38 +/- 10 vs saline control 11 +/- 8, P < 0.01). The plasma TNF alpha contents were markedly increased [(22 +/- 3) micrograms.L-1 vs saline control (2.2 +/- 1.0) micrograms.L-1, P < 0.01]. Dex 5, Cyp 5, Ani 10, or Din 2 mg.kg-1 immediately injected after i.v. LPS markedly decreased the TNF alpha mRNA levels in rat liver and plasma TNF alpha contents. The Dex, Cyp, Ani, and Din improved the mouse survival rate 24 h after LPS 20 mg.kg-1 challenge. CONCLUSION: Dex, Cyp, Ani, and Din strongly inhibit LPS-induced TNF alpha gene expression, and have a beneficial antishock effects.  (+info)

Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels. (3/134)

1. The effects of rupatadine, a new dual antagonist of both histamine H1 and platelet-activating factor receptors, were studied on human cloned hKv1.5 channels expressed in Ltk- cells using the whole-cell patch-clamp technique. 2. Rupatadine produced a use- and concentration-dependent block of hKv1.5 channels (KD=2.4+/-0.7 micronM) and slowed the deactivation of the tail currents, thus inducing the 'crossover' phenomenon. 3. Rupatadine-induced block was voltage-dependent increasing in the voltage range for channel opening suggesting an open channel interaction. At potentials positive to +10 mV the blockade decreased with a shallow voltage-dependence. Moreover, rupatadine also modified the voltage-dependence of hKv1.5 channel activation, which exhibited two components, the midpoint of the steeper component averaging -25. 2+/-2.7 mV. 4. When the intracellular K+ concentration ([K+]i) was lowered to 25% the voltage-dependent unblock observed at positive potentials was suppressed and the activation curve in the presence of rupatadine did not exhibit two components even when the midpoint of the activation curve was shifted to more negative potentials (-30. 3+/-1.3 mV). 5. On channels mutated on the residue R485 (R485Y) which is located on the external entryway of the pore the rupatadine-induced block did not decrease at potentials positive to +10 mV. In contrast, on V512M channels rupatadine reproduced all the features of the blockade observed on wild type channels. 6. All these results suggest that rupatadine blocks hKv1.5 channels binding to an external and to an internal binding site but only at concentrations much higher than therapeutic plasma levels in man. Efflux of K+ promotes the unbinding from the external site. Furthermore, rupatadine binds to an internal site and dramatically modifies the voltage-dependence of channel opening.  (+info)

5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion. (4/134)

AIM: To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG). METHODS: Intracellular recordings were made from neurons of the isolated guinea pig IMG. RESULTS: Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14). CONCLUSION: 5-HT-induced slow depolarization is mediated by 5-HT1P receptor.  (+info)

A double blind controlled study of propranolol and cyproheptadine in migraine prophylaxis. (5/134)

Role of propranolol and cyproheptadine in the prophylaxis of migraine was studied in a controlled double blind trial. Two hundred fifty-nine patients were divided into four groups. Each group was either given a placebo, cyproheptadine, propranolol or a combination of the latter two drugs. The patients were followed for a period of three months. Significant relief in frequency, duration and severity from migranous attacks was seen in all drug treated groups over placebo. Significant correlation in response was seen in frequency, duration and severity in all the groups which received drugs. Statistically more significant relief was seen in cyproheptadine and propranolol treated group as compared to individual drug treated groups. In cyproheptadine and propranolol treated groups, the dropout rate was lower and associated symptoms were better relieved than in other groups. The study shows efficacy of combination of cyproheptadine and propranolol in migraine prophylaxis.  (+info)

Verapamil, cyproheptadine, and anisodamine antagonized [Ca2+]i elevation induced by TNFalpha in a single endothelial cell. (6/134)

AIM: To study the effect of tumor necrosis factor alpha (TNFalpha) on intracellular free Ca2+ concentration ([Ca2+]i) and the effects of verapamil (Ver), cyproheptadine (Cyp), and anisodamine (Ani) on TNFalpha-induced [Ca2+]i changes in single endothelial cell, and to explore the mechanisms of TNFalpha-mediated shock and antishock actions of Cyp and Ani. METHODS: Human umbilical vein endothelial cell strains (ECV304) were seeded in 35-mm tissue culture dish with 2 mL DMEM culture medium. The cultured cells were loaded by Fluo-3/AM. The spatial distribution and the dynamic changes of [Ca2+]i in single endothelial cell were determined by laser scanning confocal microscopy. RESULTS: After stimulation with TNFalpha, [Ca2+]i in single endothelial cell rapidly increased in a concentration-dependent manner and arrived at the peak value within 60 s, afterwards, decreased and kept above the basal level. The confocal scanning image showed that [Ca2+]i elevation was more obvious in nuclear than in cytoplasma and decreased slowly. Ver (1, 2 micromol/L), Cyp (30, 60 micromol/L), and Ani (20, 40 micromol/L) markedly inhibited TNFalpha 1.2 nmol/L-induced [Ca2+]i elevation. CONCLUSION: TNFalpha markedly induces elevation of [Ca2+]i in a single endothelial cell, it may be an important mechanism of TNFalpha-induced shock and tissue injury. That Cyp and Ani obviously suppress TNFalpha-induced [Ca2+]i elevation probably is one of the mechanisms of their antishock effects.  (+info)

Anti-endotoxic shock effects of cyproheptadine in rats. (7/134)

OBJECTIVE: To investigate the antagonistic effect and mechanism of the effect of cyproheptadine (Cyp) on endotoxic shock in rats. METHODS: Endotoxic shock was produced in rats by i.v. injection of lipopolysaccharides (LPS) (5 mg/kg). Tumor necrosis factor (TNF(alpha)) mRNA expression was assessed by Northern blot. Plasma TNF(alpha) content was measured by radioimmunoassay. Plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were measured. The intracellular free calcium concentration ([Ca(2+)](i)) in single endothelial cells was determined by laser scanning confocal microscopy (LSCM). RESULTS: Cyp 5 mg/kg injected immediately after i.v. LPS raised the mean arterial blood pressure (MABP) of shocked rats and improved their 24 h survival rate. Meanwhile, Cyp markedly decreased TNF(alpha) mRNA levels in rat liver (18 +/- 10 vs. LPS + saline 38 +/- 10, P < 0.01) as well as plasma TNF(alpha) content [(7.8 +/- 2.4) microg/L vs. LPS + saline (21.5 +/- 3.2) microg/L, P < 0.01)]. It enhanced plasma SOD activity [(1037.2 +/- 112.8) NU/L vs LPS + saline (615.4 +/- 92.6) NU/L, P < 0.01], reduced the MDA content [(5.2 +/- 1.1) micromol/L vs. LPS + saline (9.8 +/- 1.5) micromol/L, P < 0.01], and inhibited TNF(alpha)-induced [Ca(2+)](i) elevation. CONCLUSION: Cyp exerts an anti-endotoxic shock effect by inhibiting TNF(alpha) gene expression, enhancing SOD activity, reducing lipid peroxidation, and preventing [Ca(2+)](i) overload.  (+info)

Suppressive effect of cyproheptadine on L-DOPA-induced growth hormone release in man. (8/134)

In order to elucidate the relationship between dopaminergic and serotoninergic mechanisms in regulating secretion of human growth hormone (hGH), the effect of cyproheptadine, an antiserotoninergic agent, on l-DOPA-induced hGH secretion was studied in normal subjects. Oral administration of 500 mg of l-DOPA caused a rise in plasma hGH in 6 of 7 subjects studied. This rise in plasma hGH was significantly blunted by the intravenous infusion of 5 mg of cyproheptadine. These results suggest the close relationship between dopamine and serotonin in the control of hGH secretion.  (+info)

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Obesity is one of the main risk factors of non-communicable diseases (NCDs) worldwide, especially in sub-Saharan Africa. The use of Cyproheptadine increases body weight and the risk of becoming obese. The aim of this study is to determine the prevalence of Cyproheptadine misuse in the Kinshasa population and to describe its characteristics. A cross-sectional study was conducted in two town sectors of Kinshasa, Democratic Republic of Congo (DRC), over a 4 month period (May 2011 to August 2011). Data from 499 participants, aged between 13 and 55 years were collected and analyzed. Mean and standard deviation were used for quantitative variables and frequency and percentage for categorical variables. In order to determine the relationship between socio-demographic status and Cyproheptadine use the Chi-square test was conducted. Students t-test was used to compare means age of Cyproheptadine users and non-users. Logistic regression was used to determine predictors of Cyproheptadine use. A p-value of |0.05
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Patients undergo weight and height measurements at baseline and at each follow-up visit in weeks 4 and 8 to evaluate the effect of cyproheptadine hydrochloride and duration of response. Patients or parents complete medicine logs at each follow-up visit in weeks 4 and 8 to evaluate drug compliance and tolerance. Patients also undergo measures of nutrition; and measures of body composition, lean body mass, and fat percentage using standardized equipment and procedures for measuring triceps skin fold and mid-arm muscle circumference at baseline and at the end of the study.. Patients undergo blood sample collection at baseline and at the end of the study for biomarker studies. Samples are analyzed for pre-albumin levels. ...
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entrations were measured. During the breeding season, serotonin reduced LH pulse amplitude in ovariectomized hinds (P , 0.05) and cyproheptadine reduced LH pulse frequency in both ovariectomized and ovariectomized-thyroidectomized hinds (P , 0.05 and P , 0.01, respectively). In the non-breeding season cyproheptadine reduced LH pulse frequency and amplitude in ovariectomized-thyroidectomized hinds (P , 0.01). Serotonin did not affect plasma prolactin concentration, whereas cyproheptadine caused an increase (P,0.01) in plasma prolactin concentration in both the breeding and non-breeding seasons. To determine whether these compounds acted at the level of the pituitary gland, in Experiment 2 was examined their effects on the responsiveness of the pituitary gland to an exogenous GnRH challenge in ovariectomized hinds (n = 5). During the breeding season and after induction of halothane anaesthesia, hinds received either a serotonin infusion (6.6. µg/kg i.v. per min for 15 minutes), cyproheptadine (3 ...
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Cyproheptadine is an antihistamine that is commonly used in cats and dogs to treat allergies, loss of appetite, and increased serotonin production. Come to petMD for a complete list of pet medications and prescriptions.
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Cyproheptadine is sometmes used in cats to stimulate their appetite. What about the distribution in the body after oral or intravenous application?
The entire time Ive been on cyproheptadine (about seven weeks), Ive alternated between wanting to gush to you about it and feeling an immense need to keep quiet, lest I put its effect in jeopardy.
Easy to read patient leaflet for Cyproheptadine Syrup. Includes indications, proper use, special instructions, precautions, and possible side effects.
You can take cyproheptadine before or after meals. Some people find it helps to swallow the tablets with a drink of water. If you forget to take a dose, dont worry, just take the next dose when it is due and then continue as before. Do not take two doses together to make up for a forgotten dose ...
cyproheptadine. 129-03-3 C21H21NO6. hydrastine. 118-08-1 ...
Goldberg SC, Halmi KA, Eckert ED, Casper RC, Davis JM (January 1979). "Cyproheptadine in anorexia nervosa". The British Journal ...
Cyproheptadine, Hydroxyzine, Latrepirdine, etc.) Antipsychotics Typicals (Chlorpromazine, Fluphenazine, Loxapine, Thioridazine ...
Larrey D, Geneve J, Pessayre D, Machayekhi JP, Degott C, Benhamou JP (1987). "Prolonged cholestasis after cyproheptadine- ...
Hydroxyzine Cyproheptadine Mercier-Guyon C, Chabannes JP, Saviuc P (2004). "The role of captodiamine in the withdrawal from ...
Benzocycloheptene Cyproheptadine Ketotifen Stark RJ, Valenti L, Miller GC. Management of migraine in Australian general ... serotonin syndrome or MDMA overdose in a similar manner to the closely related antihistamine/antiserotonin drug cyproheptadine ...
One particular antihistamine, cyproheptadine (Periactin), has been found to be useful. The tricyclic antidepressant doxepin has ...
The antihistamine cyproheptadine is also effective, probably due to its antiserotonergic effects. A systematic review on non- ...
Homnick, Douglas N. (2005). "Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis". Pediatric ... promethazine or cyproheptadine). Essential nutrient List of phytochemicals in food Body image Emaciation Malnutrition Stunted ...
It is a syrup containing cyproheptadine (a hepatotoxin), lysine and some vitamins. It has not been approved by the US Food and ...
89-. ISBN 978-0-520-26024-5. Schwartz, S (1999). "Use of cyproheptadine to control urine spraying and masturbation in a cat". ...
Cyproheptadine US 2546652, Plati JT , Wenner W, "Pyridindenes and process for their manufacture", assigned to F Hoffmann La ... Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. It was developed ... exhibit optical isomerism as do other chemicals of its general type ranging from pethidine and alphaprodine to cyproheptadine ...
Cyproheptadine (non-selective). *PG 01037 [26][27]. *Domperidone (peripheral D2 and D3 antagonist) ...
Dohmoto H, Takahara A, Uneyama H, Yoshimoto R (February 2003). "Cardiac Ca(2+) channel-blocking effects of the cyproheptadine ... It is derived from cyproheptadine, a compound with known antiserotonic, antihistaminic and calcium channel blocking properties ... "On the ionic mechanism of cyproheptadine-induced bradycardia in a rabbit sinoatrial node preparation". European Journal of ...
Other antagonists are MDL-100,907 (prototype of another new series of 5-HT2A antagonists) and cyproheptadine. Pizotifen is a ...
They include, but are not limited to: Chlorpromazine Cyproheptadine Metergoline Methysergide Mianserin Mirtazapine Oxetorone ... Cyproheptadine blocks 5-HT2A, H1 and is a mild anticholinergic. Methysergide is a 5-HT2A antagonist and nonselective 5-HT1 ... Pizotifen Propranolol Ritanserin Spiperone Carbinoxamine Cyproheptadine Hydroxyzine Methdilazine Pizotifen Promethazine ...
Cyproheptadine is an antihistamine and serotonin antagonist which has been effective in significantly reducing headshaking ...
Antagonists of the 5-HT2A receptor like cyproheptadine and chlorpromazine are able to reverse and mediate recovery from ...
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Riccioppo Neto F (March 1979). "The local anesthetic effect of cyproheptadine on mammalian nerve fibres". European Journal of ... Gunja N, Collins M, Graudins A (2004). "A comparison of the pharmacokinetics of oral and sublingual cyproheptadine". Journal of ... "The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea ...
Many therapies have been used including hyperbaric oxygen, dapsone, antihistamines (e.g., cyproheptadine), antibiotics, dextran ...
... cyproheptadine (Periactin), and fexofenadine (Allegra) may be taken orally to prevent and relieve some of the hives. For those ...
... which requires treatment with cyproheptadine and temperature control based on the progression of the serotonin toxicity. ...
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... is a piperidines (CHEBI:26151) cyproheptadine (CHEBI:4046) is a tertiary amine (CHEBI:32876) ... cyproheptadine (CHEBI:4046) has role gastrointestinal drug (CHEBI:55324) cyproheptadine (CHEBI:4046) has role H1-receptor ... cyproheptadine (CHEBI:4046) has role anti-allergic agent (CHEBI:50857) cyproheptadine (CHEBI:4046) has role antipruritic drug ( ... CHEBI:4046 - cyproheptadine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min ...
Cyproheptadine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Cyproheptadine will help relieve symptoms but will not treat the cause of symptoms or speed recovery. Cyproheptadine is in a ... Before taking cyproheptadine,. *tell your doctor and pharmacist if you are allergic to cyproheptadine, other antihistamines, or ... Cyproheptadine comes as a tablet and a solution (liquid) to take by mouth. It is usually taken two or three times a day. Take ...
Cyproheptadine overdose occurs when someone takes more than the normal or recommended amount ... Cyproheptadine is a type of drug called an antihistamine. These drugs are used to relieve allergy symptoms. ... Cyproheptadine is a type of drug called an antihistamine. These drugs are used to relieve allergy symptoms. Cyproheptadine ... Below are symptoms of a cyproheptadine overdose in different parts of the body. ...
A list of US medications equivalent to Cyproheptadine is available on the Drugs.com website. ... Cyproheptadine is a medicine available in a number of countries worldwide. ... Cyproheptadine. In the US, Cyproheptadine (cyproheptadine systemic) is a member of the drug class antihistamines and is used to ...
Before taking cyproheptadine,. *tell your doctor and pharmacist if you are allergic to cyproheptadine, other antihistamines, or ... Cyproheptadine will help relieve symptoms but will not treat the cause of symptoms or speed recovery. Cyproheptadine is in a ... Cyproheptadine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:*dry mouth, nose ... Cyproheptadine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this ...
Cyproheptadine has been studied for the treatment of posttraumatic stress disorder. Cyproheptadine is used in cats as an ... Cyproheptadine is a second line treatment for pituitary pars intermedia dysfunction in horses. "Cyproheptadine". Dictionary.com ... Cyproheptadine has weak antiandrogenic activity. Cyproheptadine is well-absorbed following oral ingestion, with peak plasma ... Cyproheptadine was studied in one small trial as an adjunct in people with schizophrenia whose condition was stable and were on ...
Cyproheptadine is used to treat sneezing, runny nose, itching, red or watery eyes, and other symptoms of seasonal allergies ( ... Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce ... What is cyproheptadine?. Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body ... What is the most important information I should know about cyproheptadine?. You should not use cyproheptadine if you have ...
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Active Comparator: Cyproheptadine Cross-over study. Drug: Cyproheptadine 0,25mg/kg/day orally in 2 doses per day (2mg/5 ml)for ... Cyproheptadine as an Appetite Stimulant. The recruitment status of this study is unknown. The completion date has passed and ... Effect of Cyproheptadine on Weight Gain and Feeding Behavior in 2 to 4 Years Old Children With Failure to Thrive. ... Cyproheptadine is currently clinically used as an appetite stimulant for children with failure to thrive without underlying ...
Thinking the cyproheptadine was the cause, I came off of it around two months ago. The joint pains still remain however, and ... Does anyone have any experience with Cyproheptadine and migraines as an adult? My neurologist put me on this today and all of ... HealingWell.com Forum , Diseases & Conditions , Migraine - Headache , cyproheptadine and migraines in adults ...
... cyproheptadine (Periactin) can certainly be overdosed. If you or someone you know has taken an overdose, seek immediate medical ... Like many other drugs, cyproheptadine (Periactin) can certainly be overdosed. If you or someone you know has taken an overdose ...
... Updated: Jan 02, 2019 ... Cyproheptadine (Periactin), an antihistamine/antiserotonin drug, is also used, especially in younger children. Side effects ... No good scientific evidence supports the use of tricyclic agents or cyproheptadine in the pediatric population, but many ...
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  • Cyproheptadine is a type of drug called an antihistamine. (medlineplus.gov)
  • Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. (wikipedia.org)
  • Cyproheptadine is a very potent antihistamine or inverse agonist of the H1 receptor. (wikipedia.org)
  • Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. (cigna.com)
  • Cyproheptadine is one type of antihistamine that inhibits the action of histamine, particularly its effect on H1 receptors. (petplace.com)
  • Cyproheptadine is an antihistamine that is commonly used in pets. (petmd.com)
  • Along with it's antihistamine effects, Cyproheptadine also works as an anti-serotonin agent. (petmd.com)
  • Cyproheptadine is an antihistamine, in many ways similar to other antihistamines with which we are more familiar but it is rarely used for its antihistamine effects. (marvistavet.com)
  • Common side effects of cyproheptadine stem from its antihistamine nature. (marvistavet.com)
  • Aside from acting as an antihistamine, cyproheptadine has other important properties. (marvistavet.com)
  • Cyproheptadine 4mg is an antihistamine oral medication in treating and controlling allergy responses in dogs and cats. (petcarerx.com)
  • Cyproheptadine, the active ingredient present in the medication is responsible for the antihistamine effects of the medicine. (petcarerx.com)
  • CYPROHEPTADINE (si proe HEP ta deen) is a antihistamine. (aarpmedicareplans.com)
  • Cyproheptadine is a widely used originally for the treatment of allergic animals "antihistamine" drugs. (creativebiomart.net)
  • But I have low my cyproheptadine antihistamine and eating habits off the analyses. (mr3health.com)
  • Cyproheptadine antihistamine Those men lead to took appetite cyproheptadine antihistamine organs of sodium bicarbonate that are repeatable through reliable dose and last in the empiric of 24 hours. (mr3health.com)
  • Cyproheptadine is an antihistamine drug that's used to alleviate signs allergy like watery eyes, runny nostril, itchy eyes. (benefits-of.com)
  • Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant. (nganhnuocnhatminh.com)
  • Cyproheptadine is used in cats as an appetite stimulant and as an adjunct in the treatment of asthma. (wikipedia.org)
  • Cyproheptadine for Increasing Appetite? (additudemag.com)
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  • Below are symptoms of a cyproheptadine overdose in different parts of the body. (medlineplus.gov)
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  • Cyproheptadine is used to treat allergic reactions (specifically hay fever). (wikipedia.org)
  • Cyproheptadine is also used to treat other conditions such as eczema or skin reactions to insect bites. (cigna.com)
  • Cyproheptadine is used to treat allergies and allergic reactions. (petplace.com)
  • To treat allergies and allergic reactions, cyproheptadine is dosed at 0.15 to 1 mg per poung (0.3 to 2 mg/kg) twice daily in dogs, and 2 mg per cat twice daily. (petplace.com)
  • The preliminary dose of cyproheptadine for allergic reactions in adults is four mg taken 3 times a day. (benefits-of.com)
  • Cyproheptadine also is used for the treatment of Cushing's Syndrome (an abnormal condition that is caused by excess hormones [corticosteroids]) and to treat certain types of headache such as migraine.Talk to your doctor about the possible risks of using this medication for your condition. (medlineplus.gov)
  • Cyproheptadine may also be used for purposes not listed in this medication guide. (cigna.com)
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  • Cyproheptadine is in a class of medications called antihistamines. (medlineplus.gov)
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  • Older adults should not usually take cyproheptadine because it is not as safe or effective as other medications that can be used to treat the same condition. (medlineplus.gov)
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