Macaca: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.Macaca fascicularis: A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Monkey Diseases: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).Macaca radiata: A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.Macaca nemestrina: A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.Mauritius: One of the Indian Ocean Islands, east of Madagascar. Its capital is Port Louis. It was discovered by the Portuguese in 1505, occupied by the Dutch 1598-1710, held by the French 1715-1810 when the British captured it, formally ceded to the British in 1814, and became independent in 1968. It was named by the Dutch in honor of Maurice of Nassau, Prince of Orange (1567-1625). (From Webster's New Geographical Dictionary, 1988, p742 & Room, Brewer's Dictionary of Names, 1992, p341)Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Tiletamine: Proposed anesthetic with possible anticonvulsant and sedative properties.Primate Diseases: Diseases of animals within the order PRIMATES. This term includes diseases of Haplorhini and Strepsirhini.Zolazepam: A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.Animals, LaboratoryRetroviruses, Simian: Classes of retroviruses for which monkeys or apes are hosts. Those isolated from the West African green monkey and the Asian rhesus macaque monkey are of particular interest because of their similarities to viruses causing cancer and acquired immunodeficiency syndrome (AIDS) in humans.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Simian immunodeficiency virus: Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.Simian Acquired Immunodeficiency Syndrome: Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.Social Dominance: Social structure of a group as it relates to the relative social rank of dominance status of its members. (APA, Thesaurus of Psychological Index Terms, 8th ed.)Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Herpesvirus 1, Cercopithecine: A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Housing, AnimalGibraltarIndonesia: A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.Diet, Atherogenic: A diet that contributes to the development and acceleration of ATHEROGENESIS.Erythrocebus: a genus of Old World monkeys of the family CERCOPITHECINAE that inhabit the forests and savannas of Africa. It contains only one species, ERYTHROCEBUS PATAS, also known as the patas monkey or red monkey.Ciliary Body: A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.Callithrix: A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.PrimatesMolecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Monkeypox: A viral disease infecting PRIMATES and RODENTS. Its clinical presentation in humans is similar to SMALLPOX including FEVER; HEADACHE; COUGH; and a painful RASH. It is caused by MONKEYPOX VIRUS and is usually transmitted to humans through BITES or via contact with an animal's BLOOD. Interhuman transmission is relatively low (significantly less than smallpox).PhilippinesHierarchy, Social: Social rank-order established by certain behavioral patterns.Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Aqueous Humor: The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Iris: The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.Ovariectomy: The surgical removal of one or both ovaries.Menstrual Cycle: The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Pueraria: A plant genus of the family FABACEAE a common weed of the southeast US. There has been folk use for alcoholism and liver protection. It contains puerarin, kakkalide, daidzein (isoflavonoids), and kudzusaponins (oleanene-type triterpene glycosides).Saimiri: A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.Hepatitis A Antigens: Antigens produced by various strains of HEPATITIS A VIRUS such as the human hepatitis A virus (HEPATITIS A VIRUS, HUMAN).Cercopithecus: A genus of Old World monkeys found in Africa although some species have been introduced into the West Indies. This genus is composed of at least twenty species: C. AETHIOPS, C. ascanius, C. campbelli, C. cephus, C. denti, C. diana, C. dryas, C. erythrogaster, C. erythrotis, C. hamlyni, C. lhoesti, C. mitis, C. mona, C. neglectus, C. nictitans, C. petaurista, C. pogonias, C. preussi, C. salongo, and C. wolfi.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cercopithecidae: The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Polydipsia: Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES INSIPIDUS; and NEPHROGENIC DIABETES INSIPIDUS. The condition may be psychogenic in origin.Monkeypox virus: A species of ORTHOPOXVIRUS causing an epidemic disease among captive primates.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Papio anubis: A species of baboon in the family CERCOPITHECIDAE with a somewhat different social structure than PAPIO HAMADRYAS. They inhabit several areas in Africa south of the Sahara.Smallpox: An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)Viremia: The presence of viruses in the blood.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Euthanasia, Animal: The killing of animals for reasons of mercy, to control disease transmission or maintain the health of animal populations, or for experimental purposes (ANIMAL EXPERIMENTATION).Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.Trabecular Meshwork: A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.Behavior, Animal: The observable response an animal makes to any situation.Anterior Chamber: The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)Pan troglodytes: The common chimpanzee, a species of the genus Pan, family HOMINIDAE. It lives in Africa, primarily in the tropical rainforests. There are a number of recognized subspecies.Metabolic Detoxication, Drug: Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Varicellovirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE. Its species include those causing CHICKENPOX and HERPES ZOSTER in humans (HERPESVIRUS 3, HUMAN), as well as several animal viruses.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Echothiophate Iodide: A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Cebus: A genus of the family CEBIDAE, subfamily CEBINAE, consisting of four species which are divided into two groups, the tufted and untufted. C. apella has tufts of hair over the eyes and sides of the head. The remaining species are without tufts - C. capucinus, C. nigrivultatus, and C. albifrons. Cebus inhabits the forests of Central and South America.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Hematologic Tests: Tests used in the analysis of the hemic system.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Isoflavones: 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.Plasmodium cynomolgi: A protozoan parasite that occurs naturally in the macaque. It is similar to PLASMODIUM VIVAX and produces a type of malaria similar to vivax malaria (MALARIA, VIVAX). This species has been found to give rise to both natural and experimental human infections.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Osteosarcoma, Juxtacortical: A form of osteogenic sarcoma of relatively low malignancy, probably arising from the periosteum and initially involving cortical bone and adjacent connective tissue. It occurs in middle-aged as well as young adults and most commonly affects the lower part of the femoral shaft. (Stedman, 25th ed)Cholesterol, Dietary: Cholesterol present in food, especially in animal products.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Antigens, CD20: Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cryoprotective Agents: Substances that provide protection against the harmful effects of freezing temperatures.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Soybean Proteins: Proteins which are present in or isolated from SOYBEANS.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Estrogens, Conjugated (USP): A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Animals, ZooMarburg Virus Disease: An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.Uvea: The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Organ Size: The measurement of an organ in volume, mass, or heaviness.Genes, MHC Class I: Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.Intraocular Pressure: The pressure of the fluids in the eye.Ebolavirus: A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.Cowpox: A mild, eruptive skin disease of milk cows caused by COWPOX VIRUS, with lesions occurring principally on the udder and teats. Human infection may occur while milking an infected animal.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Hinge Exons: Immunoglobulin heavy chain gene exons coding for the hinge region of the heavy chains between the first constant region (on the FAB FRAGMENTS) and the second constant region (on the FC FRAGMENTS).Retroviridae Infections: Virus diseases caused by the RETROVIRIDAE.Epididymis: The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Vasectomy: Surgical removal of the ductus deferens, or a portion of it. It is done in association with prostatectomy, or to induce infertility. (Dorland, 28th ed)Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Reassortant Viruses: Viruses containing two or more pieces of nucleic acid (segmented genome) from different parents. Such viruses are produced in cells coinfected with different strains of a given virus.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Contraception, Immunologic: Contraceptive methods based on immunological processes and techniques, such as the use of CONTRACEPTIVE VACCINES.Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Onchocerca: A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.Mauritania: A republic in western Africa, southwest of ALGERIA and west of MALI. Its capital is Nouakchott.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Lymphoid Tissue: Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.p-Hydroxyamphetamine: Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine.Asia, Southeastern: The geographical area of Asia comprising BORNEO; BRUNEI; CAMBODIA; INDONESIA; LAOS; MALAYSIA; the MEKONG VALLEY; MYANMAR (formerly Burma), the PHILIPPINES; SINGAPORE; THAILAND; and VIETNAM.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)Angiotensin Amide: The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.Quarantine: Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed & Black's Veterinary Dictionary, 17th ed)Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Sclera: The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.Sperm Agglutination: Agglutination of spermatozoa by antibodies or autoantibodies.Plague Vaccine: A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Eyelids: Each of the upper and lower folds of SKIN which cover the EYE when closed.Genetic Variation: Genotypic differences observed among individuals in a population.Grooming: An animal's cleaning and caring for the body surface. This includes preening, the cleaning and oiling of feathers with the bill or of hair with the tongue.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Accommodation, Ocular: The dioptric adjustment of the EYE (to attain maximal sharpness of retinal imagery for an object of regard) referring to the ability, to the mechanism, or to the process. Ocular accommodation is the effecting of refractive changes by changes in the shape of the CRYSTALLINE LENS. Loosely, it refers to ocular adjustments for VISION, OCULAR at various distances. (Cline et al., Dictionary of Visual Science, 4th ed)Canthaxanthin: A trans-carotenoid pigment widely distributed in nature. The compound is used as an oral suntanning agent and as a food and drug coloring agent. Oral ingestion of the compound causes canthaxanthin retinopathy.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Acrosome: The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Thermometry: Measurement of the temperature of a material, or of the body or an organ by various temperature sensing devices which measure changes in properties of the material that vary with temperature, such as ELASTICITY; MAGNETIC FIELDS; or LUMINESCENCE.Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Norprogesterones: Progesterones which have undergone ring contraction or which are lacking carbon 18 or 19.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Semen Preservation: The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Encephalomyelitis, Enzootic Porcine: A picornavirus infection producing symptoms similar to poliomyelitis in pigs.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Phytoestrogens: PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.Parvovirus: A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MINUTE VIRUS OF MICE.Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Yaba monkey tumor virus: The type species of YATAPOXVIRUS, a tumor-producing DNA virus discovered in monkeys in Yaba, Nigeria. It has been found to produce histiocytomas in monkeys and humans.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Abortifacient Agents: Chemical substances that interrupt pregnancy after implantation.Hepatitis E virus: A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Herpesviridae Infections: Virus diseases caused by the HERPESVIRIDAE.Luteal Phase: The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.Abortifacient Agents, Steroidal: Steroidal compounds with abortifacient activity.Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.Simian T-lymphotropic virus 1: A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Norpregnenes: Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Lassa virus: A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Ganglionectomy: Removal of an autonomic or sensory ganglion by any means.Atelinae: A subfamily in the family ATELIDAE, comprising three genera: woolly monkeys (Lagothrix), spider monkeys (Ateles), and woolly spider monkeys (Brachyteles).Oesophagostomum: A genus of nematodes of the superfamily STRONGYLOIDEA, parasitic in the intestines of animals. The adults are usually free in the intestinal lumen; the larvae encyst in the wall.Body Temperature: The measure of the level of heat of a human or animal.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Oesophagostomiasis: Infection of the intestinal tract with worms of the genus OESOPHAGOSTOMUM. This condition occurs mainly in animals other than man.Spleen: An encapsulated lymphatic organ through which venous blood filters.Vaccines, Attenuated: Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.Mutant Chimeric Proteins: Proteins produced from GENES that have mutated by the fusing of protein coding regions of more than one gene. Such hybrid proteins are responsible for some instances of ANTIBIOTIC RESISTANCE and defective biological processes such as NEOPLASMS.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Lepromin
Wikimedia Commons has media related to Macaca fascicularis.. *Bonadio, C. 2000. "Macaca fascicularis" (On-line), Animal ... It is referred to as the cynomolgus monkey in laboratories. It has a long history alongside humans; it has been ... "Makaku, macaco, macaque, macaca". Language Log. Retrieved 2013-09-26.. *^ Raffles, Thomas Stamford (1821). "Descriptive ... Macaca comes from the Portuguese word macaco, which was derived from makaku, a word in Ibinda, a language of Central Africa ( ...
List of sequenced animal genomes
Macaca fascicularis, Cynomolgus or crab-eating macaque (2011). *Family Hominidae *Subfamily Ponginae *Pongo pygmaeus/Pongo ... Macaca mulatta, rhesus macaque (2007 & Chinese rhesus macaque Macaca mulatta lasiota in 2011) ... October 2011). "Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus ...
Crab-eating Macaque - Simple English Wikipedia, the free encyclopedia
Ong, P. & Richardson, M. (2008). Macaca fuscicularis. 2008 IUCN Red List of Threatened Species. IUCN 2008. Retrieved on 4 ... It is also called the Cynomolgus Monkey, Philippine Monkey and the Long-tailed Macaque. ... The Crab-eating macaque (Macaca fascicularis) is a monkey. It is mostly native to Southeast Asia. ...
Simian foamy virus
The first full genome annotation of a proviral SFV isolated from cynomolgus macaque (Macaca fascicularis) had been performed in ... Macaca mulatta) model". Viruses. 5 (6): 1414-1430. doi:10.3390/v5061414. ISSN 1999-4915. PMC 3717714 . PMID 23744104. Mergia, ... "First Complete Genome Sequence of a Simian Foamy Virus Isolate from a Cynomolgus Macaque". Genome Announcements. 4 (6): e01332- ...
Genus Macaca M. sylvanus group Barbary macaque, M. sylvanus M. nemestrina group Lion-tailed macaque, M. silenus Southern pig- ... also known as cynomolgus or long-tailed macaque) Stump-tailed macaque, M. arctoides M. mulatta group Rhesus macaque, M. mulatta ... Li, C.; Zhao, C.; Fan, P. (25 Mar 2015). "White-cheeked macaque (Macaca leucogenys): A new macaque species from Modog, ... The macaques (/məˈkɑːk/ or /məˈkæk/) constitute a genus (Macaca) of Old World monkeys of the subfamily Cercopithecinae. The 23 ...
The SRV serotype-2 was found in endemic infections of pig-tailed monkey (M. nemestrina), cynomolgus macaques, Japanese macaque ... Macaca mulatta) in 1970. This prototype virus now belongs to SRV serotype-3 group. SRV-1 serotype was identified in early 1980s ... In 2010, a Japanese research group reported two SRV isolates from seropositive cynomolgus macaques and tentatively designated ... "Isolation and Characterization of Simian Retrovirus Type D from Macaca fascicularis and M. nemestrina in Indonesia". ...
The macaques (/məˈkɑːk/ or /məˈkæk/) constitute a genus (Macaca) of Old World monkeys of the subfamily Cercopithecinae. The ... M. fascicularis (also known as cynomolgus or long-tailed macaque) Southeast Asia ... "Primate Factsheets: Long-tailed macaque (Macaca fascicularis) Conservation". pin.primate.wisc.edu. Retrieved 2018-07-02.. ... "Primate Factsheets: Long-tailed macaque (Macaca fascicularis) Conservation". pin.primate.wisc.edu. Retrieved 2018-07-02.. ...
Zhong Zhong and Hua Hua
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Macaca fascicularis (Nicobar Crab-eating Macaque, Nicobar Cynomolgus Monkey, Nicobar Long-tailed Macaque)
Calretinin-immunoreactive local circuit neurons in area 17 of the cynomolgus monkey, Macaca fascicularis
Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis). -...
Projections from Guddens tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis).. ... In a parallel study, horseradish peroxidase was injected into the mammillary bodies of five cynomolgus monkeys (Macaca ... Projections From Guddens Tegmental Nuclei to the Mammillary Body Region in the Cynomolgus Monkey (Macaca fascicularis) ... Projections From Guddens Tegmental Nuclei to the Mammillary Body Region in the Cynomolgus Monkey (Macaca fascicularis) ...
Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis) - Volume 11, Number 12-December 2005 - Emerging Infectious...
Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis). Emerging Infectious Diseases. 2005;11(12):1931-1934. doi: ... A young adult female cynomolgus monkey (Macaca fascicularis), born October 1, 1998, in a breeding facility in Vietnam, was ... Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis). Emerg Infect Dis. 2005;11(12):1931-1934. https://dx.doi.org/ ... Our findings support the close relationship of B. quintana and the new cynomolgus monkey isolate. The evolutionary distance ( ...
Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of...
The unique demographic history of the Mauritian cynomolgus macaques provides the opportunity to not only examine the genetic ... Macaca fascicularis) were introduced to the island of Mauritius by humans around the 16th century. ... Cynomolgus macaques (Macaca fascicularis) were introduced to the island of Mauritius by humans around the 16th century. The ... Whole-genome sequencing of six Mauritian Cynomolgus macaques (Macaca fascicularis) reveals a genome-wide pattern of ...
Histiocytic Sarcoma in a Cynomolgus Macaque (<i>Macaca fascicularis</i>) Fed with a...
AID 64212 - Inhibition of [3H]WIN-35428 binding to Dopamine transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca...
Simian Betaretrovirus Infection in a Colony of Cynomolgus Monkeys (<i xmlns="http://pub2web.metastore.ingenta.com/ns/">Macaca...
RePub, Erasmus University Repository: Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca...
Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles ... Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles ... Both rhesus and cynomolgus macaques have been used as animal models for measles I vaccination and immunopathogenesis studies. A ... Collectively, these data show that cynomolgus and rhesus macaques are equally susceptible to wild-type MV infection, although ...
btla, Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) b- and T-lymphocyte attenuator-like DNA. - Creative Biogene
Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca f...
Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques (Macaca mulatta).: Cefovecin sodiu ... Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques ( ... The pharmacokinetic properties of cefovecin were evaluated in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio ... The half-life of cefovecin was 4.95 ± 1.47 h in cynomolgus macaques, 9.17 ± 1.84 h in olive baboons, and 8.40 ± 2.53 h in ...
Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Macaca Fascicularis) | IOVS | ARVO Journals
Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Macaca Fascicularis) S Umeda; R Ayyagari; MT Suzuki; Y Yoshikawa; F ... Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Macaca Fascicularis) You will receive an email whenever this article ... ELOVL4 was cloned from Cynomolgus monkey (Macaca Fascicularis). Gene sequence and structure of ELOVL4 was similar to human and ... Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Macaca Fascicularis) . Invest. Ophthalmol. Vis. Sci. 2002;43(13):2807 ...
Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis<...
Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcoholism: Clinical ... Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. In: Alcoholism: ... Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. / Ivester, Priscilla; ... The objectives of this study were (1) to evaluate whether cynomolgus monkeys (Macaca fascicularis) drinking ethanol voluntarily ...
Cytological examination of bone marrow fom xenografted cynomolgus monkeys (macaca fascicularis)
Introduction: Non-human primates (NHP) are frequently used in preclinical research, including xenotransplantation studies. Cytological examination of bone marrow (BM) is a helpful adjunct for a complete interpretation of hematological data. In this light, the aim of this work is to evaluate the cellular composition of BM in immunosuppressed xenotransplanted NHP. Materials and Methods: Ten NHP recipients of a life-supporting porcine kidney were treated with Cyclosporin A, steroids, Mycophenolate sodium, with Cyclophosphamide (CYP) (N=6) or Rituximab (N=4). Eight animals were euthanized for kidney failure and 2 for life-threatening conditions. A complete pre-euthanasia CBC and 4 femoral BM smears collected at euthanasia were performed. Cytological evaluations and differential counts of erythroid, granulocytic, lymphocytic and plasmacytic series were performed. Megakariocytic series elements were evaluated with regards to number, morphology and maturation. The myeloid to erythroid ratio (M:E) was ...
Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus...
Cynomolgus macaques (Macaca fasicularis) were infected intracerebrally with BSE-positive brain stem material from cattle and ... In a second approach, we analysed ERV-K-(HML-2) RNA and protein expression in extracts from the same cynomolgus macaques. Here ... Cynomolgus macaques are an excellent model for human acquired prion disease. TSEs can be transmitted to Macaca fascicularis ... Cynomolgus macaques (Macaca fasicularis) were infected intracerebrally with BSE-positive brain stem material from cattle and ...
The Macaque Ovary, with Special Reference to the Cynomolgus Macaque ( Macaca fascicularis )
The Macaque Ovary, with Special Reference to the Cynomolgus Macaque (Macaca fascicularis). ... Concerning functional and morphological aspects, the ovary of the cynomolgus macaque is representative for the conditions in ... Against this background, a comprehensive overview about the cynomolgus macaque ovary is given from its embryonic appearance, ... to the human organism indicating the similarity of both species and hence underlining the importance of the cynomolgus macaque ...
loc100430657, Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) uncharacterized LOC100430657 DNA. - Creative Biogene
In Vitro Cellular & Developmental Biology - Animal - Springer
Naturally Occurring Immune-Complex Glomerulonephritis in Cynomolgus Monkeys (Macaca irus). I. Light, Immunofluorescence, and...
... and electron microscopic studies were carried out on renal biopsies from 32 randomly selected adult cynomolgus monkeys Macaca ... Naturally Occurring Immune-Complex Glomerulonephritis in Cynomolgus Monkeys (Macaca irus). I. Light, Immunofluorescence, and ... and electron microscopic studies were carried out on renal biopsies from 32 randomly selected adult cynomolgus monkeys Macaca ...
Summary Comparison of Female Reproductive System in Human and the Cynomolgus Monkey (Macaca fascicularis): /OConnor/ZIKV-003
Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis) - Volume 11, Number 12-December 2005 - Emerging Infectious...
Macaca fascicularis). This report describes naturally acquired B. quintana infection in a nonhuman primate. ... extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus ... Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis). Emerging Infectious Diseases. 2005;11(12):1931-1934. doi: ... A young adult female cynomolgus monkey (Macaca fascicularis), born October 1, 1998, in a breeding facility in Vietnam, was ...
Description of vertebral and liver alveolar echinococcosis cases in Cynomolgus monkeys (Macaca fascicularis) | BMC Veterinary...
In March 2011, a 5-year-old zoo-raised male cynomolgus macaque (Macaca fascicularis) presented a paresis of the lower limbs ... In June 2013, at necroscopy, a hepatic and a paravertebral masses were detected in a second cynomolgus macaque of the same ... The first animal was a 5-year-old male cynomolgus macaque (Macaca fascicularis) born in Mauritius and raised for 3 years in a ... In March 2011, a 5-year-old zoo-raised male cynomolgus macaque (Macaca fascicularis) presented a paresis of the lower limbs ...
Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range - pdf...
Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range. . ... MethodTo explore this further, we utilised a non-human primate model Macaca fascicularis Cynomolgus macaque which shares with ... Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range. ... Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range - ...
December - Page 2 - Mahidol University
Table 2 - Animal Reservoirs and Hosts for Emerging Alphacoronaviruses and Betacoronaviruses - Volume 27, Number 4-April 2021 -...
Cynomolgus macaque (Macaca fascicularis). Japanese quail (Coturnix japonica). Mink (Neovison vison). Domestic cat (Felis catus) ... Rhesus macaque (Macaca mulatta). Severe acute respiratory syndrome coronavirus (SARS-CoV). Bats; family Rhinolophidae. [Masked ... Rhesus macaque (Macaca mulatta). Severe acute respiratory syndrome-related coronavirus 2 (SARS-related CoV-2). [Bats: family ...
Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating...
Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating ... Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating ... The genes encoding the cynomolgus monkey gonadotropin subunits, alpha, follicle-stimulating hormone (FSH) beta and luteinizing ... towards production of recombinant monkey LH and FSH which can be used in a homologous experimental setting in the cynomolgus ...
Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co...
Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A Cynomolgus monkeys (Macaca ... Nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of B19V infection and/or a faecal ... Macaca fascicularis Type of study: Policy_brief Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical ... The present results demonstrated, for the first time, the susceptibility of cynomolgus to B19V infection, but it did not show a ...
Index | In the Light of Evolution: Volume IV: The Human Condition | The National Academies Press
- The unique demographic history of the Mauritian cynomolgus macaques provides the opportunity to not only examine the genetic background of well-established nonhuman primates for biomedical research but also understand the effect of an extreme population bottleneck on the pattern of polymorphisms in genomes. (nih.gov)
- We sequenced the whole genomes of six Mauritian cynomolgus macaques and obtained an average of 20-fold coverage of the genome sequences for each individual. (nih.gov)
- The overall level of nucleotide diversity was 23% smaller than that of the Malaysian cynomolgus macaques, and a reduction of low-frequency polymorphisms was observed. (nih.gov)
- In addition, we also confirmed that the Mauritian cynomolgus macaques were genetically closer to a representative of the Malaysian population than to a representative of the Indochinese population. (nih.gov)
- Excess of nonsynonymous polymorphisms in low frequency, which has been observed in many other species, was not very strong in the Mauritian samples, and the proportion of heterozygous nonsynonymous polymorphisms relative to synonymous polymorphisms is higher within individuals in Mauritian than Malaysian cynomolgus macaques. (nih.gov)
- Both rhesus and cynomolgus macaques have been used as animal models for measles I vaccination and immunopathogenesis studies. (eur.nl)
- Collectively, these data show that cynomolgus and rhesus macaques are equally susceptible to wild-type MV infection, although infection in the skin seems to follow a different course in rhesus macaques. (eur.nl)
- Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca f. (mysciencework.com)
- The half-life of cefovecin was 4.95 ± 1.47 h in cynomolgus macaques, 9.17 ± 1.84 h in olive baboons, and 8.40 ± 2.53 h in rhesus macaques. (mysciencework.com)
- Cynomolgus macaques ( Macaca fasicularis ) were infected intracerebrally with BSE-positive brain stem material from cattle and allowed to develop prion disease. (biomedcentral.com)
- In a second approach, we analysed ERV-K-(HML-2) RNA and protein expression in extracts from the same cynomolgus macaques. (biomedcentral.com)
- Here we investigated the pathogenic potential of swine H2N3 in Cynomolgus macaques, a surrogate model for human influenza infection. (plos.org)
- To distinguish the relative contributions of the protein moiety versus the alcohol-extractable phytoestrogens for cardiovascular protection, we studied young male cynomolgus macaques fed a moderately atherogenic diet and randomly assigned to three groups. (ahajournals.org)
- Passive immunization protects cynomolgus macaques against Puumala hantavirus challenge. (curehunter.com)
- Here, we studied the effect of passive immunization on the course of infection in cynomolgus macaques challenged with wild-type Puumala hantavirus (PUUV-wt). (curehunter.com)
- 2009 ). Many of the DRB alleles of rhesus ( Mamu-DRB ) and cynomolgus monkeys ( Mafa-DRB ) belong to loci/lineages that are shared between humans and macaques: namely, DRB1 , DRB3 , DRB4 , and DRB5 , as well as DRB6 , with the latter appearing to be a pseudogene in all primate species studied. (springer.com)
- 2000 ). In rhesus and cynomolgus macaques, two to three DRB loci per haplotype appear to be expressed. (springer.com)
- We report a cluster of alveolar echinococcosis in 24 animals of different Old World monkey species (15 cynomolgus monkeys, 5 rhesus monkeys, and 4 lion-tailed macaques) in northern Germany. (ajtmh.org)
- Pathogenesis of Lassa fever in cynomolgus macaques. (nih.gov)
- The present work shows that a combination of three neutralizing monoclonal antibodies (mAbs) directed against the Ebola envelope glycoprotein (GP) resulted in complete survival (four of four cynomolgus macaques) with no apparent side effects when three doses were administered 3 days apart beginning at 24 hours after a lethal challenge with EBOV. (sciencemag.org)
- The same treatment initiated 48 hours after lethal challenge with EBOV resulted in two of four cynomolgus macaques fully recovering. (sciencemag.org)
- African green monkeys, hamadryad baboons, cynomolgus macaques, and rhesus macaques have all been used as nonhuman primate (NHP) filovirus infection models ( 2 ). (sciencemag.org)
- Because African green monkeys and hamadryad baboons are somewhat resistant to some filoviruses, both cynomolgus and rhesus macaques have been routinely used for the study of EBOV, and both show the same disease profile for EBOV infections. (sciencemag.org)
- 2020. Utility of automated feeding data to detect social instability in a captive breeding colony of rhesus macaques (Macaca mulatta): A case study of intrafamily aggression. (awionline.org)
- Behavioral predictors of pairing success in rhesus macaques (Macaca mulatta). (awionline.org)
- Both strains cause lethal disease in cynomolgus macaques with similar pathologic changes and hallmark features of Ebola hemorrhagic fever. (cdc.gov)
- Subjects were nine postreproductive rhesus macaques (Macaca mulatta), five females and four males. (brown.edu)
- The composition of the microbiota in cynomolgus macaques is only partially characterized, although this animal model is often used to study pathogenesis and preventive strategies against infections. (frontiersin.org)
- We thus performed, for the first time, a longitudinal characterization of the vaginal and rectal microbiota of five cycling female cynomolgus macaques. (frontiersin.org)
- The rectal and vaginal bacterial composition in cynomolgus macaques is polymicrobial and clearly distinct, with larger individual variability in the vagina. (frontiersin.org)
- Our study provides a detailed characterization of the rectal and vaginal microbiota in female cynomolgus macaques and opens new perspectives of this animal model. (frontiersin.org)
- Lactational Performance in primiparous and multiparous captive rhesus macaques ( Macaca mulatta ) American Society of Primatologists Meeting, San Antonio, Texas, August. (sputtr.com)
- Natural Migration Patterns Predict Escapes from a Colony of Japanese Macaques (Macaca fuscata), by S. M. Lehman & L. L. Taylor. (brown.edu)
- Wind Direction is Associated with Daily Variation in Use of an Island by a Troop of Stumptail Macaques (Macaca arctoides), by D R. Rasmussen, R. Biggs, & R. Gorena. (brown.edu)
- The subjects were 14 female rhesus macaques (Macaca mulatta) 13-18 months of age. (brown.edu)
- Immunohistochemical staining of tissue from a series of macaque monkeys (Macaca mulatta) showed that cells in the region of both the ventral and dorsal tegmental nuclei selectively stain for parvalbumin, thus helping to reveal these nuclei. (nih.gov)
- A number of studies have suggested that experimental measles virus (MV) infection induces more-characteristic clinical features in rhesus than in cynomolgus monkeys. (eur.nl)
- Following infection, all rhesus monkeys developed a skin rash and conjunctivitis, which were less obvious in cynomolgus monkeys. (eur.nl)
- Methods: Six adult male and 6 adult female cynomolgus monkeys were allowed to consume ethanol voluntarily for 18 to 19 months. (elsevier.com)
- Conclusion: Our studies show that cynomolgus monkeys undergoing voluntary ethanol consumption for 1.5 years exhibit many of the features observed in the early stages of human alcoholic liver disease. (elsevier.com)
- Naturally Occurring Immune-Complex Glomerulonephritis in Cynomolgus Monkeys (Macaca irus). (dtic.mil)
- Light, immunofluorescence, and electron microscopic studies were carried out on renal biopsies from 32 randomly selected adult cynomolgus monkeys Macaca irus. (dtic.mil)
- A number of AE cases have been described in captive cynomolgus monkeys in Switzerland where AE involved mainly the liver, but also the pancreas, lungs, kidneys or lymph nodes. (beds.ac.uk)
- Nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of B19V infection and/or a faecal suspension of acute HAV. (bvsalud.org)
- To this end, the effects of chronic ethanol self-administration on glutamate receptor ionotropic AMPA (GRIA) subunit variant and kainate (GRIK) subunit mRNA expression were studied in the orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DLPFC), and anterior cingulate cortex (ACC) of male cynomolgus monkeys. (frontiersin.org)
- 3 That observation prompted us to extend those studies to further ascertain whether the soy phytoestrogens could diminish or prevent diet-induced CAA in young male cynomolgus monkeys. (ahajournals.org)
- For the present study, a cohort of 230 cynomolgus monkeys, including self-sustaining breeding groups, has been examined. (springer.com)
- 1.0g/kg) oral alcohol self-administration on social behavior in eight adolescent male cynomolgus monkeys. (asp.org)
- Cynomolgus monkeys were very susceptible and constituted the monkey species at highest risk, indicating that this species could act as a sentinel animal for the transmission of alveolar echinococcosis in zoological gardens or similar institutions. (ajtmh.org)
- Outbreak of larval Echinococcus multilocularis infection in Japanese monkey ( Macaca fuscata ) in a zoo, Hokkaido: western blotting patterns in the infected monkeys. (ajtmh.org)
- Six cynomolgus monkeys were experimentally infected with LASV. (nih.gov)
- Clinical chemistry values after infection of cynomolgus monkeys with Lassa virus. (nih.gov)
- A single immunization with rPA plus DV230-Ficoll induced 10-fold higher titers of toxin-neutralizing Abs in cynomolgus monkeys at 2 wk compared with animals immunized with equivalent amounts of monomeric DV230. (jimmunol.org)
- This report, the first to describe a non-human primate experimentally infected with M. ulcerans , suggests that cynomolgus monkeys are modestly susceptible and develop some of the clinical and histologic features of Buruli ulcer. (ajtmh.org)
- CR in cynomolgus monkeys may alter insulin signaling in vivo by modulating protein content of insulin receptor signaling proteins. (diabetesjournals.org)
- Specifically, we demonstrated that CR improved insulin sensitivity and reduced intra-abdominal fat with aging in a 4-year study in cynomolgus monkeys ( 14 ). (diabetesjournals.org)
- Zurich 1970, vol. 3, pp. 180-191 87 ( Karger, Basel 1971) Sexual Climax in Female Macaca mulatta FRANCES D. BURTON Department of Anthropology, University of Toronto, Toronto Permission to reprint this article here was kindly given by S. Karger, AG. (sputtr.com)
- Antibody reacts with NGAL (neutrophil gelatinase-associated lipocalin) from Macaca mulatta (Rhesus) and Macaca facicularis (Cynomolgus). (fishersci.com)
- We report a case of histiocytic sarcoma in 11-year-old male cynomolgus macaque fed with a high-fat diet for 6 years. (go.jp)
- Concerning functional and morphological aspects, the ovary of the cynomolgus macaque is representative for the conditions in higher primates like humans and is therefore of major relevance in toxicological research. (ovid.com)
- Against this background, a comprehensive overview about the cynomolgus macaque ovary is given from its embryonic appearance, throughout the adolescent and adult development until old age. (ovid.com)
- Special emphasis is also laid on the comparison to the human organism indicating the similarity of both species and hence underlining the importance of the cynomolgus macaque as a model in toxicological research. (ovid.com)
- In June 2013, at necroscopy, a hepatic and a paravertebral masses were detected in a second cynomolgus macaque of the same colony. (beds.ac.uk)
- Comparison of the vaginal cynomolgus macaque microbiota with that of humans showed similarity to community state type IV-A usually associated with dysbiosis. (frontiersin.org)
- however, MGSTs have not been fully investigated in cynomolgus macaque, an important primate species widely used in drug metabolism and toxicity studies. (aspetjournals.org)
- For comparison with the cynomolgus cDNAs, MGST2 and MGST3 cDNAs were also isolated from rhesus macaque (closely related to cynomolgus macaque) liver. (aspetjournals.org)
- Cynomolgus MGST2 and MGST3, respectively, were highly identical (99 and 98%) to human MGST2 and MGST3 and nearly identical to the amino acid sequences of the rhesus orthologs, and they were closely clustered with human MGST2 and MGST3 by phylogenetic analysis. (aspetjournals.org)
- Therefore, cynomolgus MGSTs have molecular similarities to the corresponding human MGSTs. (aspetjournals.org)
- These results suggest that these functional cynomolgus MGST enzymes and the corresponding human MGSTs are molecularly similar. (aspetjournals.org)