Pregnane and pregnane glycosides from the Malagasy plant, Cynanchum aphyllum. (1/10)

A new 8,14-seco-pregnane type of steroid called cynaphyllogenin and its eight glycosides, cynaphyllosides A-H, were isolated from the aerial parts of Cynanchum aphyllum. The structures of these compounds were elucidated based on chemical and spectroscopic evidence.  (+info)

Comparative study of the effects of various culture conditions on cell growth and Gagaminine synthesis in suspension culture of Cynanchum wilfordii (MAXIM.) HEMSLEY. (2/10)

Gagaminine, a steroidal alkaloid isolated from the roots of Cynanchum wilfordii, exhibited potent inhibitory effects on aldehyde oxidase activity and lipid peroxidation. To determine whether it would be possible to mass produce this active component, which would be useful for animal tests, we tried to synthesize it using in vitro cell culture methods with various growth conditions. In a previous study it was found that calli were easily induced from the stem of this medicinal plant and cultivated effectively on MS medium containing 2,4-dichlorophenoxyacetic acid (2,4-D) 2 mg/l. In this work we attempted to determine the effects of various culture conditions on cell growth and gagaminine synthesis in suspension culture. Gagaminine production was increased markedly when cell growth proceeded to the death phase. Cell growth was more effective with 5% (v/v) sucrose, in the light (at 38 microE/m(2) x s), on medium containing 2,4-D 2 mg/l, with 2.5 g/10 ml medium as the initial cell concentration. The concentration of gagaminine was optimal with 3% sucrose, in darkness on medium 2,4-D 1 mg/l, with 2.5 g/10 ml medium as an initial cell concentration. However, the highest growth rate was 0.18 d(-1), when the gagaminine concentration was seven- and three-fold (at 140 mu/ml) that of the plant stem and 10 ml of medium respectively, on the 50 ml of medium in suspension culture.  (+info)

The anti-inflammatory and anti-nociceptive effects of ethyl acetate fraction of cynanchi paniculati radix. (3/10)

The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cynanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.  (+info)

Glycosides of 14,15-seco and 13,14:14,15-disecopregnanes from the roots of Cynanchum sublanceolatum. (4/10)

Thirty-two new 13,14-seco and 13,14:14,15-disecopregnane glycosides were obtained from the roots of Cynanchum sublanceolatum (Asclepiadaceae). These glycosides were confirmed to be possessing five known compounds, cynajapogenin A, glaucogenin-A, 13-hydroxycynajapogenin A, 2alpha-hydroxyanhydrohirundigenin, atratogenin A and one new pregnane, 13-epi-cynajapogenin A, as their aglycones, using both spectroscopic and chemical methods.  (+info)

Androstane and monoterpene glucoside sinapoyl ester from Cynanchum amplexicaule SIEB. et ZUCC. (5/10)

A new androstane, 17beta-hydroxy-androsta-4,6,15-trien-3-one (1) and a new monoterpene glucoside sinapoyl ester, (3R)-8-hydroxylinalool 3,8-di-O-beta-D-(6'-O-E-sinapoyl)glucopyranoside (2) were isolated from the roots of Cynanchum amplexicaule SIEB. et ZUCC. (Asclepiadaceae), along with two known monoterpenes, (3R)-8-hydroxylinalool (3) and (6R)-menthiafolic acid (4). Their structures were elucidated on the basis of analyses of physical, chemical, and spectral data.  (+info)

Three new steroidal glycosides from the roots of Cynanchum auriculatum. (6/10)

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Purification and characterization of a CkTLP protein from Cynanchum komarovii seeds that confers antifungal activity. (7/10)

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Improved endothelial dysfunction by Cynanchum wilfordii in apolipoprotein E(-/-) mice fed a high fat/cholesterol diet. (8/10)

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