A cardiotonic cardiac glycoside found in STROPHANTHUS. The aglycone is STROPHANTHIN.

Increase in dissociation rate constants of cardiotonic steroid-brain (Na+ + K+)-ATPase complexes by reduction of the unsaturated lactone. (1/2)

Several cardiotonic steroids have been modified by reduction of the unsaturated lactone and their interactions with the sodium- and potassium-activated ATPase ((Na+ + K+)-ATPase) have been investigated. Reduction of the unsaturated lactone results in a decrease in binding affinity due primarily to an increase in the dissociation rate constant concomitant with a decrease in the activation free energy of dissociation. This decrease in activation free energy is about 2 to 4 kcal, which is approximately equal to the energy of one hydrogen bond. It is suggested that the increase in dissociation rate due to reduction of the unsaturated lactone may make possible the use of these compounds as affinity ligands for purification of the (Na+ + K+)-ATPase or an ouabain-binding fragment.  (+info)

Photoaffinity labeling of (Na+K+)-ATPase with [125I]iodoazidocymarin. (2/2)

A radioiodinated, photoactive cardiac glycoside derivative, 4'-(3-iodo-4-azidobenzene sulfonyl)cymarin (IAC) was synthesized and used to label (Na+K+)-ATPase in crude membrane fractions. In the dark, IAC inhibited the activity of (Na+K+)-ATPase in electroplax microsomes from Electrophorus electricus with the same I50 as cymarin. [125I]IAC binding, in the presence of Mg2+ and Pi, was specific, of high affinity (KD = 0.4 microM), and reversible (k-1 = 0.11 min-1) at 30 degrees C. At 0 degree C, the complex was stable for at least 3 h, thus permitting washing before photolysis. Analysis of [125]IAC photolabeled electroplax microsomes by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) (7-14%) showed that most of the incorporated radioactivity was associated with the alpha (Mr = 98,000) and beta (Mr = 44,000) subunits of the (Na+K+)-ATPase (ratio of alpha to beta labeling = 2.5). A higher molecular weight peptide (100,000), similar in molecular weight to the brain alpha(+) subunit, and two lower molecular weight peptides (12,000-15,000), which may be proteolipid, were also labeled. Two-dimensional gel electrophoresis (isoelectric focusing then SDS-PAGE, 10%) resolved the beta subunit into 12 labeled peptides ranging in pI from 4.3 to 5.5. When (Na+K+)-ATPase in synaptosomes from monkey brain cortex was photolabeled and analyzed by SDS-PAGE (7-14%), specific labeling of the alpha(+), alpha, and beta subunits could be detected (ratio of alpha(+) plus alpha to beta labeling = 35). The results show that [125I]IAC is a sensitive probe of the cardiac glycoside binding site of (Na+K+)-ATPase and can be used to detect the presence of the alpha(+) subunit in crude membrane fractions from various sources.  (+info)

I'm sorry, but I couldn't find any information on a medical term called "Cymarine." It's possible that you may have misspelled the term or that it is not a commonly used term in the medical field. If you have any additional information or context, please let me know and I'll do my best to assist you.

... (or cymarine) is a cardiac glycoside. Plants of the genus Apocynum, including Apocynum cannabinum and Apocynum venetum ...
National Center for Biotechnology Information, U.S. National Library of Medicine, Cymarine "Apocynum L." Plants of the World ...
Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin digitoxigenin digoxigenin digoxin medigoxin neoconvalloside ...
... cymarine MeSH D09.408.180.810.600 - ouabain MeSH D09.408.210.209 - chromomycin a3 MeSH D09.408.320.500 - methylgalactosides ...
... cymarine MeSH D04.808.155.580.810.600 - ouabain MeSH D04.808.221.263 - cholenes MeSH D04.808.221.430 - cholic acids MeSH ... cymarine MeSH D04.808.155.160.861.600 - ouabain MeSH D04.808.155.160.861.700 - strophanthidin MeSH D04.808.155.580 - cardiac ...
Cymarine D4.808.155.160.861.250 Cynanchum B1.650.940.800.575.100.99.110 B1.650.940.800.575.100.81.325 Cystine Knot Motifs ...
Cymarine D4.808.155.160.861.250 Cynanchum B1.650.940.800.575.100.99.110 B1.650.940.800.575.100.81.325 Cystine Knot Motifs ...
Cymarine D4.808.155.160.861.250 Cynanchum B1.650.940.800.575.100.99.110 B1.650.940.800.575.100.81.325 Cystine Knot Motifs ...
Cymarine D4.808.155.160.861.250 Cynanchum B1.650.940.800.575.100.99.110 B1.650.940.800.575.100.81.325 Cystine Knot Motifs ...
Cymarine D4.808.155.580.130.750.250 D4.210.500.155.580.130.750.250 Cynanchum B1.650.940.800.575.100.81.325 B1.650.940.800. ...
Cymarine D4.808.155.580.130.750.250 D4.210.500.155.580.130.750.250 Cynanchum B1.650.940.800.575.100.81.325 B1.650.940.800. ...
k-Strophanthin-alpha use Cymarine K562 Cells Kadipiro virus use Coltivirus Kadsura ...
k-Strophanthin-alpha use Cymarine. kappa B Enhancer Binding Protein use NF-kappa B ...
k-Strophanthin-alpha use Cymarine K562 Cells Kaayam use Asafoetida (Homeopathy) Kadipiro virus use Coltivirus ...
k-Strophanthin-alpha use Cymarine K562 Cells Kaayam use Asafoetida (Homeopathy) Kadipiro virus use Coltivirus ...
k-Strophanthin-alpha use Cymarine K562 Cells Kaayam use Asafoetida (Homeopathy) Kadipiro virus use Coltivirus ...
k-Strophanthin-alpha use Cymarine K562 Cells Kaayam use Asafoetida (Homeopathy) Kadipiro virus use Coltivirus ...
k-Strophanthin-alpha use Cymarine K562 Cells Kadipiro virus use Coltivirus Kadsura ...
less than 10 -12 mg cymarine cardiac glycosides per pellet (**contains 0.443 mg of the active ingredient per pellet) ...
Heidenreich PA, Solis P, Estes NAM 3rd, Fonarow GC, Jurgens CY, Marine JE, McManus DD, McNamara RL. Heidenreich PA, et al. J Am ... Heidenreich PA, Solis P, Mark Estes NA 3rd, Fonarow GC, Jurgens CY, Marine JE, McManus DD, McNamara RL. Heidenreich PA, et al. ...
Cymarine D4.808.155.580.130.750.250 D4.210.500.155.580.130.750.250 Cynanchum B1.650.940.800.575.100.81.325 B1.650.940.800. ...
use CYMARINE to search TSIMARIN 1975-92. History Note. 91(75); was see under STROPHANTHINS 1975-90; TSIMARIN was see CYMARINE ... Cymarine Preferred Term Term UI T010218. Date01/01/1999. LexicalTag NON. ThesaurusID ... Cymarine Preferred Concept UI. M0005498. Registry Number. UK3LS8435E. Related Numbers. 508-77-0. Scope Note. A cardiotonic ... Cymarine. Tree Number(s). D04.210.500.155.580.130.750.250. D09.408.180.810.250. Unique ID. D003529. RDF Unique Identifier. http ...
use CYMARINE to search TSIMARIN 1975-92. History Note. 91(75); was see under STROPHANTHINS 1975-90; TSIMARIN was see CYMARINE ... Cymarine Preferred Term Term UI T010218. Date01/01/1999. LexicalTag NON. ThesaurusID ... Cymarine Preferred Concept UI. M0005498. Registry Number. UK3LS8435E. Related Numbers. 508-77-0. Scope Note. A cardiotonic ... Cymarine. Tree Number(s). D04.210.500.155.580.130.750.250. D09.408.180.810.250. Unique ID. D003529. RDF Unique Identifier. http ...
N0000007903 Cyclosporins N0000167470 Cyclosteroids N0000006856 cyclothiazide N0000170350 Cyclotides N0000168454 Cymarine ...
Cymarine D4.808.155.160.861.250 Cynanchum B1.650.940.800.575.100.99.110 B1.650.940.800.575.100.81.325 Cystine Knot Motifs ...
D12.776.476.262 Cymarine D4.808.155.580.810.250 D4.808.155.580.130.750.250 Cyproheptadine D2.455.426.559.847.181.384.340 ...
Cymarine D4.808.155.580.130.750.250 D4.210.500.155.580.130.750.250 Cynanchum B1.650.940.800.575.100.81.325 B1.650.940.800. ...
k-Strophanthin-alpha use Cymarine K562 Cells Kaayam use Asafoetida (Homeopathy) Kadipiro virus use Coltivirus ...

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