Devices for accelerating charged particles in a spiral path by a constant-frequency alternating electric field. This electric field is synchronized with the movement of the particles in a constant magnetic field.
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.
The study of the chemical and physical phenomena of radioactive substances.
Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.
A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.
A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Agents capable of exerting a harmful effect on the body.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
Electronic devices that increase the magnitude of a signal's power level or current.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.
Chromatographic techniques in which the mobile phase is a liquid.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
A chromatography technique in which the stationary phase is composed of a non-polar substance with a polar mobile phase, in contrast to normal-phase chromatography in which the stationary phase is a polar substance with a non-polar mobile phase.
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms).
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Persons or entities that introduce a novel composition, device, or process, as well as improvements thereof.
Objects that produce a magnetic field.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A plant genus of the family ZINGIBERACEAE. Members contain aculeatin D, beta-sitosterol, and STIGMASTEROL. Some members have been reclassified to ELETTARIA and other ZINGIBERACEAE.
Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.
A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
Areas of attractive or repulsive force surrounding MAGNETS.
The study of MAGNETIC PHENOMENA.
A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)
Revealing of information, by oral or written communication.
The promotion and support of consumers' rights and interests.
Norms, criteria, standards, and other direct qualitative and quantitative measures used in determining the quality of health care.
The use of an external beam of PROTONS as radiotherapy.
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.

Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams. (1/157)

Hypoxanthine phosphoribosyltransferase gene (hprt) mutations were induced in human TK-6 lymphoblastoid cells by irradiation at a linear energy transfer (LET) of 250 or 310 keV/micron for carbon and neon ions, respectively. At such a high level of LET, ions will lose most of their total energy and stop shortly after passing through the cell. The hprt mutations were analyzed by multiplex PCR, long-PCR and DNA sequencing of both genomic and cDNA. Over half of the C ion-induced hprt mutations (10 of 19) were point mutations, in contrast to 15% of the mutations induced by Ne ions (three of 20). The remaining 47 and 85% of the C and Ne ion-induced mutants, respectively, are deletion events. The latter events include three complex losses of multiple non-contiguous exon regions in both ion irradiation collections. We note that mutations involving the exon 6 region are frequent in the Ne ion collection: all three of the complex events retained the exon 6 region with flanking deletion of sequence and three other mutants involved deletion of this region. It may be concluded that these high-LET C and Ne ion irradiations produce different mutational spectra.  (+info)

Fourier transform ion cyclotron resonance mass spectrometric detection of small Ca(2+)-induced conformational changes in the regulatory domain of human cardiac troponin C. (2/157)

Troponin C (TnC), a calcium-binding protein of the thin filament of muscle, plays a regulatory role in skeletal and cardiac muscle contraction. NMR reveals a small conformational change in the cardiac regulatory N-terminal domain of TnC (cNTnC) on binding of Ca2+ such that the total exposed hydrophobic surface area increases very slightly from 3090 +/- 86 A2 for apo-cNTnC to 3108 +/- 71 A2 for Ca(2+)-cNTnC. Here, we show that measurement of solvent accessibility for backbone amide protons by means of solution-phase hydrogen/deuterium (H/D) exchange followed by pepsin digestion, high-performance liquid chromatography, and electrospray ionization high-field (9.4 T) Fourier transform Ion cyclotron resonance mass spectrometry is sufficiently sensitive to detect such small ligand binding-induced conformational changes of that protein. The extent of deuterium incorporation increases significantly on binding of Ca2+ for each of four proteolytic segments derived from pepsin digestion of the apo- and Ca(2+)-saturated forms of cNTnC. The present results demonstrate that H/D exchange monitored by mass spectrometry can be sufficiently sensitive to detect and identify even very small conformational changes in proteins, and should therefore be especially informative for proteins too large (or too insoluble or otherwise intractable) for NMR analysis.  (+info)

Formation and characterization of iron-oligonucleotide complexes with matrix-assisted laser desorption/ionization fourier transform ion cyclotron resonance mass spectrometry. (3/157)

Iron-containing oligonucleotide negative ions can be generated by matrix-assisted laser desorption/ionization from a stainless steel target disk (by either defocusing the laser beam or by mixing iron salts such as FeCl3 with the matrix compound during the sample preparation). High resolution mass measurements reveal the presence of both Fe2+ (as M + Fe - 3H)- and Fe3+ (as M + Fe - 4H)- in the metal-oligonucleotide ions. The presence of Fe3+ is unexpected, and must involve replacement of protons from the nucleic bases or ribose groups as well as the phosphate groups of the oligonucleotides. Inspection of a range of small oligonucleotides and mononucleotides reveals that the presence of both Fe2+ and Fe3+ in the iron-biomolecule complexes is dependent on the number of acidic hydrogens that can be replaced in the oligonucleotide or nucleotide. Collisional dissociation of several metal-tetranucleotide ions revealed that the presence of the iron ion alters the fragmentation observed. The iron atom was observed to be present in all of the fragment ions, and, whenever possible, seemed to enhance the abundance of fragment ions containing both iron and a guanine nucleic base. These results suggest that iron may serve as a useful probe for characterizing phosphorylated biomolecules.  (+info)

Laser desorption in transmission geometry inside a Fourier-transform ion cyclotron resonance mass spectrometer. (4/157)

We report here the first application of laser desorption (LD) in transmission geometry (backside irradiation of the sample through a transparent support) inside a Fourier-transform ion cyclotron resonance mass spectrometer (FT-ICR). A probe-mounted fiber optic assembly was used to simplify the implementation of this LD technique. This setup requires little or no instrument modifications, has minimum maintenance requirements, and is relatively inexpensive to build. The performance of the probe was tested by determining the molecular weight of a commercial polystyrene standard from its matrix-assisted laser desorption/ionization (MALDI) spectrum. The measured average molecular weight is comparable to that obtained for the same sample by MALDI in the conventional top-illumination arrangement (reflection geometry) and by the manufacturer of the sample by gel permeation chromatography. The average velocities measured for ions evaporated by transmission mode LD of several neat samples are about half the velocity of those obtained by using the reflection geometry. Therefore, transmission mode irradiation of the sample holds promise to desorb ions that are easier to trap in an ICR cell. An oscillating capillary nebulizer was adapted for the deposition of analytes to improve sampling reproducibility.  (+info)

Determination of 3,3'-dichlorobenzidine and its degradation products in environmental samples with a small low-field Fourier transform ion cyclotron resonance mass spectrometer. (5/157)

3,3'-Dichlorobenzidine (DCB) and its degradation products, 3-chlorobenzidine (MCB) and benzidine, are of environmental concern because of their carcinogenic nature. The suitability of a small Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer for the analysis of these environmental contaminants in different types of matrices was explored. All the measurements were carried out by depositing the sample solution directly on a disk that was introduced into the mass spectrometer. This approach is very fast and simple because it requires no prior chromatographic separation or derivatization. Calibration curves determined by collecting 70-eV electron ionization mass spectra of neat samples yielded lower limits of detection of 29 and 17 pg (total amount on the solids probe) for DCB and benzidine, respectively (based on a signal to noise ratio of > or = 2:1), while chemical ionization with ammonia resulted in lower limits of detection of 21 pg for DCB and 9 pg for benzidine (total amount on the solids probe). FT-ICR analysis of sediments collected from Lake Macatawa (Holland, MI) verified the presence of DCB in this complex, environmentally significant sample matrix. Laboratory experiments designed to probe biodegradation and photodegradation pathways showed that DCB undergoes sequential dehalogenation to yield MCB and then benzidine under exposure to microorganisms and under simulated tropospheric solar radiation. The ability of the FT-ICR to determine elemental compositions of compounds introduced as described above was demonstrated for one of the degradation products.  (+info)

Initial implementation of an electrodynamic ion funnel with Fourier transform ion cyclotron resonance mass spectrometry. (6/157)

Fourier transform ion cyclotron resonance (FTICR) mass spectrometry has become a widely used method to study biopolymers. The method, in combination with an electrospray ionization (ESI) source has demonstrated the highest resolution and accuracy yet achieved for characterization of biomolecules and their noncovalent complexes. The most common design for the ESI interface includes a heated capillary inlet followed by a skimmer having a small orifice to limit gas conductance between a higher pressure (1 to 5 torr) source region and the lower pressure ion guide. The ion losses in the capillary-skimmer interface are large (estimated to be more than 90%) and thus reduce achievable sensitivity. In this work, we report on the initial implementation of a newly developed electrodynamic ion funnel in a 3.5 tesla ESI-FTICR mass spectrometer. The initial results show dramatically improved ion transmission as compared to the conventional capillary-skimmer arrangement. An estimated detection limit of 30 zeptomoles (approximately 18,000 molecules) has been achieved for the analysis of the proteins with molecular weights ranging from 8 to 20 kDa.  (+info)

Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of the recombinant human macrophage colony stimulating factor beta and derivatives. (7/157)

The potential of electrospray ionization (ESI) Fourier transform ion cyclotron mass spectrometry (FTICR-MS) to assist in the structural characterization of monomeric and dimeric derivatives of the macrophage colony stimulating factor beta (rhM-CSF beta) was assessed. Mass spectrometric analysis of the 49 kDa protein required the use of sustained off-resonance irradiation (SORI) in-trap cleanup to reduce adduction. High resolution mass spectra were acquired for a fully reduced and a fully S-cyanylated monomeric derivative (approximately 25 kDa). Mass accuracy for monomeric derivatives was better than 5 ppm, after applying a new calibration method (i.e., DeCAL) which eliminates space charge effects upon high accuracy mass measurements. This high mass accuracy allowed the direct determination of the exact number of incorporated cyanyl groups. Collisionally induced dissociation using SORI yielded b- and y-fragment ions within the N- and C-terminal regions for the monomeric derivatives, but obtaining information on other regions required proteolytic digestion, or potentially the use of alternative dissociation methods.  (+info)

Electrospray ionization Fourier transform ion cyclotron resonance analysis of large polymerase chain reaction products. (8/157)

In previous work, we demonstrated the use of electrospray ionization to analyze small differences in size or sequence of relatively small polymerase chain reaction (PCR) products of 114 base pairs or less. The sequence information required to answer a biological question may be only a single nucleotide substitution or deletion. In many cases, the regions where these sequence variations can occur are several hundred base pairs in length, and the analysis of large PCR products is therefore desirable. Therefore, we have attempted to expand the size range of PCR products that can be analyzed by electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometry. Previous work has shown that the difficulties associated with PCR product analysis increase with product size. A revised cleanup scheme was employed to target the removal of detergents with ethanol wash or precipitation steps, followed by additional desalting. Additionally, an in-trap cleanup to collisionally induce dissociation of noncovalent salt adducts was employed. This approach was extended to a 223 base pair PCR product yielding mass measurement accuracy within 26 ppM. The mass measurement accuracy obtained illustrates that a single base substitution could be identified at this size of PCR product with a 7 tesla ESI-FTICR.  (+info)

TY - JOUR. T1 - Atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry for complex thiophenic mixture analysis. AU - Hourani, Nadim. AU - Andersson, Jan T.. AU - Möller, Isabelle. AU - Amad, Maan H.. AU - Witt, Matthías. AU - Sarathy, Mani. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The work at KAUST was funded by the Clean Combustion Research Center and by Saudi Aramco under the FUELCOM program.. PY - 2013/10/1. Y1 - 2013/10/1. N2 - Rationale Polycyclic aromatic sulfur heterocycles (PASHs) are detrimental species for refining processes in petroleum industry. Current mass spectrometric Methods that determine their composition are often preceded by derivatization and dopant addition approaches. Different ionization Methods have different impact on the molecular assignment of complex PASHs. The analysis of such species under atmospheric pressure chemical ionization (APCI) is still considered limited due to uncontrolled ion ...
Search and download thousands of Swedish university dissertations (essays). Full text. Free. Dissertation: High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
Abstract In this study, a reliable and sensitive ultrahigh performance liquid chromatography coupled with fourier transform ion cyclotron resonance mass spectrometry method was developed for the systematic study of the metabolic profile of Kudiezi injection in rat plasma, bile, urine, and feces after intravenous administration of a single dose....
A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass ...
Structural information obtained by negative-ion laser desorption ionization Fourier transform ion cyclotron resonance (l.d.i.-F.t-i.c.r.) mass spectrometry on bacterial capsular ...
Аннотация доклада: Fourier Transform Ion Cyclotron Resonance Mass spectrometry (FTICR MS) is widely used to explore molecular space of humic substances. However, it cannot easily distinguish between structural isomers. We have developed an approach of selective H/D exchange (HDX) coupled to FTICR MS, which provides information about C-H bonds of individual species. This study demonstrates feasibility of comparing structures with common molecular formulas identified in HS from different sources. We believe that combination of different selective isotope labeling techniques will enable identification of individual molecular compartments of natural HS. ...
Polyolefins such as polyethylene (PE) and polypropylene (PP) are often characterized from their pyrolysis products by Py-MS. Nowadays the development of plasma-based direct probe atmospheric pressure sources allow the direct analysis of these polymers. These sources operate at atmospheric pressure, which implies a limited control of the ionization conditions. It was shown that side reactions could occur with species present in air, such as O2, which may lead to the formation of oxidized compounds. In this work, ion mobility-mass spectrometry (IM-MS) and Fourier transform ion cyclotron resonance mass spectrometry (FTICR) were used for the exhaustive characterization of the PP and PE pyrolysis ions produced using plasma-based atmospheric pressure ion sources. Both PP and PE yielded distributions of pyrolysis products presenting different amounts of unsaturation but also different numbers of oxygen atoms. In addition, the ions produced from PP presented a lower collision cross-section (CCS) than those
This review offers an introduction to the principles and generic applications of FT-ICR mass spectrometry, directed to readers with no prior experience with the technique. We are able to explain the fundamental FT-ICR phenomena from a simplified theoretical treatment of ion behavior in idealized mag …
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
The detailed glycan structural analysis of glycoprotein is amenable to glycopeptide enrichment. Here, we develop a simple, effective and economical approach to enrich glycopeptides from proteolytically digested peptide mixtures by chromatographic column packed with graphite carbon and activated charcoal (G/A-column). Glycopeptide from ovalbumin was efficiently enriched by homemade G/A-column using liquid chromatography and the structure of glycopeptide was obtained by tandem mass spectrometry using Fourier transform ion cyclotron resonance mass spectrometry. The results in this study demonstrate that G/A-column can be used to enrich N-glycolpeptides and be benefit for online identification of glycopeptide using LC-MS.
Diastereochemical differentiation of β-amino acids using host-guest complexes studied by fourier transform ion cyclotron resonance mass spectrometry | Anna R.M. Hyyryläinen; Jaana M.H. Pakarinen; Pirjo Vainiotalo; Géza Stájer; Ferenc Fülöp | download | BookSC. Download books for free. Find books
Electrospray ionization (ESI) was performed on a Fourier transform ion cyclotron resonance mass spectrometer for the endgroup and monomer mass determination of three poly(oxyalkylene)s in the mass range of 400-8000 Da. A combined use of the multiple charge states observed with ESI, leads to a threefold increase in accuracy of the endgroup and monomer determination. The improvement is attributed to the increased number of datapoints used for the regression procedure, yielding more accurate results. Endgroup masses are determined with a mass error better than 5 and 75 millimass units for the molecular weight range of 400-4200 and 6200-8000 Da, respectively. A mass error of better than 1 millimass unit was observed for all monomer mass determinations. With ESI, endgroup and monomer masses have been determined for poly(ethylene glycol) oligomers with a mass higher than 8000 Da. This is almost two times higher than observed with matrix-assisted laser desorption/ ionization on the same ...
article{4bf893b7-614c-4304-ae07-10d1532c9337, abstract = {,p,The feasibility of global glycoprotein analysis by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and infrared multiphoton dissociation (IRMPD) tandem mass spectrometry is demonstrated. Combined 2D gel glycoprotein separation and visualization, in-gel digestion, and accurate (<10 ppm) mass measurement allowed identification of human glycoproteins and revealed differences in glycosylation. IRMPD obviates the need for glycan release, which prevents sample dispersal, and allows the assignment of glycan structures to specific sites of N-glycosylation.,/p,}, author = {Håkansson, Kristina and Emmett, Mark R and Marshall, Alan G and Davidsson, Pia and Nilsson, Carol L}, issn = {1535-3893}, keyword = {Carbohydrate Conformation,Carbohydrate Sequence,Electrophoresis, Gel, Two-Dimensional,Glycoproteins,Humans,Mass Spectrometry,Molecular Sequence Data,Peptides,Protein Conformation,Protein Isoforms,Journal ...
Motivation: The development of better tests to detect cancer in its earliest stages is one of the most sought-after goals in medicine. Especially important are minimally invasive tests that require only blood or urine samples. By profiling oligosaccharides cleaved from glycosylated proteins shed by tumor cells into the blood stream, we hope to determine glycan profiles that will help identify cancer patients using a simple blood test. The data in this article were generated using matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI FT-ICR MS). We have developed novel methods for analyzing this type of mass spectrometry data and applied it to eight datasets from three different types of cancer (breast, ovarian and prostate).. Results: The techniques we have developed appear to be effective in the analysis of MALDI FT-ICR MS data. We found significant differences between control and cancer groups in all eight datasets, including two ...
TY - CONF. T1 - Lipidomic Analysis by Liquid Chromatography-Ion Cyclotron Resonance Mass Spectrometry. AU - Fauland, Alexander. AU - Trötzmüller, Martin. AU - Guo, Xinghua. AU - Eberl, Anita. AU - Köfeler, Harald. AU - Lankmayr, Ernst. PY - 2011/9/18. Y1 - 2011/9/18. M3 - (Old data) Lecture or Presentation. ER - ...
TY - JOUR. T1 - Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer. AU - An, Hyun Joo. AU - Miyamoto, Suzanne. AU - Lancaster, Katherine S.. AU - Kirmiz, Crystal. AU - Li, Bensheng. AU - Lam, Kit. AU - Leiserowitz, Gary S. AU - Lebrilla, Carlito B. PY - 2006/7. Y1 - 2006/7. N2 - A glycomic approach is developed to identify oligosaccharide markers for ovarian cancer by rapidly profiling globally released oligosaccharides. Glycoproteins shed by cancer cells are found in the supernatant (or conditioned media) of cultured cells. In this approach, shed glycoproteins are profiled for their oligosaccharide content using β-elimination conditions. Changes in glycosylation are monitored by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS). Because shed glycoproteins would also be found in serum, similar glycan profiling was performed to observe potential oligosaccharide markers. Oligosaccharide ...
Glycomics, a comprehensive study of glycans expressed in biologic systems, is emerging as a simple yet highly sensitive diagnostic tool for disease onset and progression. This study aimed to use glycomics to investigate glycan markers that would differentiate patients with gastric cancer from those with nonatrophic gastritis. Patients with duodenal ulcer were also included because they are thought to represent a biologically different response to infection with Helicobacter pylori, a bacterial infection that can cause either gastric cancer or duodenal ulcer. We collected 72 serum samples from patients in Mexico City that presented with nonatrophic gastritis, duodenal ulcer, or gastric cancer. N-glycans were released from serum samples using the generic method with PNGase F and were analyzed by matrix-assisted laser desorption/ionization Fourier transform-ion cyclotron resonance mass spectrometry. The corresponding glycan compositions were calculated based on accurate mass. ANOVA-based ...
Positive-ion electrospray-fourier transform ion cyclotron resonance mass spectra of polypeptides and proteins.: We have determined the mass spectra of three pol
Bovine β-lactoglobulin (β-Lg) is a major allergen existing in milk and causes about 90% of IgE-mediated cows milk allergies. Previous studies showed that pulsed electric field (PEF) treatment could partially unfold the protein, which may contribute to the improvement of protein glycation. In this study, the effect of PEF pretreatment combined with glycation on the IgG/IgE-binding ability and the structure of β-Lg was investigated. The result showed that PEF pretreatment combined with glycation significantly reduced the IgG and IgE binding abilities, which was attributed to the changes of secondary and tertiary structure and the increase in glycation sites and degree of substitution per peptide (DSP) value determined by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD/FTICR-MS ...
Beryllium-7 (Be-7) only decays by electron capture into lithium-7 (Li-7) with a half life of 53 days. We study the effect of ionization on this decay rate. We do so by trapping a Be-7 ion plasma in a cylindrical Malmberg-Penning trap and measuring Be-7 and Li-7 concentrations as functions of time by using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). We have simulated these signals in a 2-dimensional electrostatic particle-in-cell (PIC) code. The two spectrum peaks merge at high ion densities whereas at low ion densities they can be resolved. The merged peak shifts linearly according to the relative abundances of these species. We have also simulated singly-ionized beryllium-7 hydride (BeH+) and Li-7 ion plasmas at high densities. These two separate peaks shift according to their relative abundances. We describe an analytical model that explains how these peaks shift.
The production of biosurfactant by Bacillus subtilis LSFM-05 was carried out using raw glycerol, obtained from a vegetable oil biodiesel plant in Brazil, as the sole carbon source. Production of the biosurfactant was carried out in a 15-L bench-top fermentor and the surfactant was obtained from the foam produced. The crude surfactant was purified by silica gel column chromatography with a yield of 230 mg of the purified biosurfactant per liter of foam. TLC, IR spectroscopy. H-1 and C-13 NMR and Fourier transform ion cyclotron resonance mass spectrometry with electrospray ionization (ESI-FTMS) were used to characterize the purified surfactant. The isolated surfactant was identified as a surfactin lipopeptide. MS/MS data identified the amino acid sequence as GluOMe-Leu-Leu-Asp-Val-Leu-Leu and showed that the fatty acid moiety contained 14 carbons in iso, anteiso or normal configurations. The critical micelle concentration of the C-14/Leu(7) surfactin was 70 mu M, with emulsification efficiency ...
Characterization of oil sands naphthenic acids treated with ultraviolet and microwave radiation by negative ion electrospray Fourier transform ion cyclotron resonance mass spectrometry (pages 3121-3126). John V. Headley, Kerry M. Peru, Sabyasachi Mishra, Venkatesh Meda, Ajay K. Dalai, Dena W. McMartin, Mmilili M. Mapolelo, Ryan P. Rodgers and Alan G. Marshall. Version of Record online: 5 OCT 2010 , DOI: 10.1002/rcm.4754. ...
Native top-down electrospray ionization-mass spectrometry of 158 kDa protein complex by high-resolution Fourier transform ion cyclotron resonance mass spectrometry ...
A non-invasive diagnostic approach is crucial for the evaluation of severity of liver disease, treatment decisions, and assessing drug efficacy. This study evaluated plasma proteomic profiling via an N-terminal isotope tagging strategy coupled with liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry measurement to detect liver fibrosis staging. Pooled plasma from different liver fibrosis stages, which were assessed in advance by the current gold-standard of liver biopsy, was quantitatively analyzed. A total of 72 plasma proteins were found to be dysregulated during the fibrogenesis process, and this finding constituted a valuable candidate plasma biomarker bank for follow-up analysis. Validation results of fibronectin by Western blotting reconfirmed the mass-based data. Ingenuity Pathways Analysis showed four types of metabolic networks for the functional effect of liver fibrosis disease in chronic hepatitis B patients. Consequently, quantitative proteomics via the ...
ePIC (electronic Publication Information Center) is the official repository for publications and presentations of Alfred Wegener Institute for Polar and Marine Research (AWI)
Hydrogen/deuterium exchange (HDX) coupled to mass spectrometry permits analysis of structure, dynamics, and molecular interactions of proteins. HDX mass spectrometry is confounded by deuterium exchange-associated peaks overlapping with peaks of heavy, natural abundance isotopes, such as carbon-13. Recent studies demonstrated that high-performance mass spectrometers could resolve isotopic fine structure and eliminate this peak overlap, allowing direct detection and quantification of deuterium incorporation. Here, we present a graphical tool that allows for a rapid and automated estimation of deuterium incorporation from a spectrum with isotopic fine structure. Given a peptide sequence (or elemental formula) and charge state, the mass-to-charge ratios of deuterium-associated peaks of the specified ion is determined. Intensities of peaks in an experimental mass spectrum within bins corresponding to these values are used to determine the distribution of deuterium incorporated. A theoretical spectrum can
With a highly sensitive electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) system, proteins were identified in minimal amounts of spinal cord from patients with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and compared to proteins in spinal cord from control subjects. The results show 18 versus 16 significantly identified (p | 0.05) proteins, respectively, all known to be found in the central nervous system. The most abundant protein in both groups was the glial fibrillary acidic protein, GFAP. Other proteins were, for example, hemoglobin alpha- and beta chain, myelin basic protein, thioredoxin, alpha enolase, and choline acetyltransferase. This study also includes the technique of laser microdissection in combination with pressure catapulting (LMPC) for the dissection of samples and specific neurons. Furthermore, complementary experiments with nanoLC-matrix assisted laser desorption ionization time-of-flight tandem mass spectrometry
To identify release points, assess fate, and monitor exposure, we need reliable methods for detecting and quantifying engineered carbon nanomaterials (ECNs) in the environment. However, quantitative extraction and separation of ECNs from environmental sample is extremely difficult. Additionally, ECNs are indistinguishable from graphitic carbon ubiquitous in the environment in regions of the electromagnetic spectrum probed by modern spectroscopy, including absorption, fluorescence, scattering (at UV, IR, and X-ray wavelengths), and NMR. We use a novel approach based upon a unique molecular signature of ECNs C zero mass defect. The detection is enabled by atmospheric pressure photoionization (APPI) coupled with ultrahigh resolution ion cyclotron resonance mass spectrometer. We were able to detect trace concentration of molecular C60 in the presence of aquatic natural organic matter ...
TY - JOUR. T1 - Conformational epitope mapping of Pru du 6, a major allergen from almond nut. AU - Willison, LeAnna N.. AU - Zhang, Qian. AU - Su, Mengna. AU - Teuber, Suzanne S. AU - Sathe, Shridhar K.. AU - Roux, Kenneth H.. PY - 2013/10. Y1 - 2013/10. N2 - Tree nuts are a widely consumed food. Although enjoyed safely by most individuals, allergic reactions to tree nuts, including almond, are not uncommon. Almond prunin (Pru du 6), an 11S globulin (legumin), is an abundant nut seed protein and a major allergen. Conformational epitope mapping studies of prunin have been performed with a murine monoclonal antibody (mAb) 4C10. This mAb reacts with non-reduced but not reduced prunin in immunoblotting assays, indicating the recognition of a conformational epitope. 4C10 competes with patient IgE, as assessed by ELISA, indicating clinical significance of the epitope. To characterize the 4C10 epitope, hydrogen/deuterium exchange (HDX) monitored by 14.5. T Fourier transform ion cyclotron resonance mass ...
Cyclotron Market - Scope of the Report. TMRs report on the global cyclotron market studies past as well as current growth trends and opportunities to gain valuable insights of the same indicators for the market during the forecast period from 2020 to 2030. The report provides revenue of the global cyclotron market for the period 2018-2030, considering 2019 as the base year and 2030 as the forecast year. The report also provides the compound annual growth rate (CAGR) for the global cyclotron market during the forecast period.. The report has been prepared after an extensive primary and secondary research. Primary research involves bulk of research efforts, wherein analysts carried out interviews with industry leaders and opinion makers. Extensive secondary research involves referring to key players product literature, annual reports, press releases, and relevant documents to understand the global cyclotron market.. Secondary research also includes Internet applications, statistical data from ...
TY - JOUR. T1 - Phase-space resolved measurement of 2nd harmonic ion cyclotron heating using FIDA tomography at the ASDEX Upgrade tokamak. T2 - Paper. AU - Weiland, M.. AU - Bilato, R.. AU - Geiger, B.. AU - Schneider, P. A.. AU - Tardini, G.. AU - Garcia-Muñoz, M.. AU - Ryter, F.. AU - Salewski, Mirko. AU - Zohm, H.. PY - 2017. Y1 - 2017. N2 - Recent upgrades to the FIDA (fast-ion D-alpha) diagnostic at ASDEX Upgrade allow to reconstruct the fast-ion phase space at several radial positions with decent energy and pitch resolution. These new diagnostic capabilities are applied to study the physics of 2nd harmonic ion cyclotron heating, which is a foreseen heating scenario for ITER. In particular, the acceleration of deuterium beam ions above the injection energy by absorption of ion cyclotron waves at the 2nd harmonic is investigated and compared to theoretical predictions by the TORIC-SSFPQL and TORIC-NUBEAM code packages. Furthermore, comparisons to other fast-ion diagnostics (neutron yield ...
The effect of ion cyclotron resonance heating (ICRH) on ((3)He)D plasmas at JET was studied with the time of flight optimized rate (TOFOR) spectrometer dedicated to 2.5 MeV dd neutron measurements. In internal transport barrier (ITB) plasma experiments with large (3)He concentrations (X((3)He),15%) an increase in neutron yield was observed after the ITB disappeared but with the auxiliary neutral beam injection and ICRH power still applied. The analysis of the TOFOR data revealed the formation of a high energy (fast) D population in this regime. The results were compared to other mode conversion experiments with similar X((3)He) but slightly different heating conditions. In this study we report on the high energy neutron tails originating from the fast D ions and their correlation with X((3)He) and discuss the light it can shed on ICRH-plasma power coupling mechanisms.. ...
Minimal staff and maintenance requirements. This is a fully-shielded system with integrated cyclotron, chemistry and quality control systems occupying minimal space in a hospital environment, and very easy to operate and maintain. The activities of the Model 200 can be remotely monitored from TBGs Support Department to assist in service and daily operation. These units are manufactured in USA using proprietary technologies.. TBG is planning to offer these units globally for medical and other institutions where availability of isotopes is often challenging - making it difficult to image patients on a timely basis to diagnose diseases at an early stage. TBG has extensive experience in the design, development and manufacture of unique accelerators, including cyclotrons for medical, research and industrial applications. TBG is in the process of expanding its manufacturing facilities in the USA to produce several cyclotron units on a monthly basis. TBG is the only cyclotron manufacturing company ...
Electromagnetic ion cyclotron (EMIC) waves and their role in governing proton populations in the ring current and radiation belt regions are of importance in understanding the dynamics of the Earths magnetosphere. The availability of SCATHA magnetic field and proton spectra data allowed us to study the electromagnetic proton cyclotron instability as a generation mechanism for EMIC waves and the relationship between EMIC waves and protons in the equatorial region of the magnetosphere. To identify EMIC waves and obtain wave power spectra from the SCATHA magnetic field data, we employed the fast Fourier transform and spectral analysis techniques. First, we studied the conditions under which the electromagnetic proton cyclotron instability acts as a generation mechanism for EMIC waves in the Earths magnetosphere. The results are consistent with those of previous studies and/or with theoretical expectations. Especially, the results show an inverse correlation between proton temperature anisotropy ...
An experimental campaign aiming to investigate electron cyclotron resonance (ECR) plasma X-ray emission has been recently carried out at the ECRISs-Electron Cyclotron Resonance Ion Sources laboratory of Atomki based on a collaboration between the Debrecen and Catania ECR teams. In a first series, the X-ray spectroscopy was performed through silicon drift detectors and high purity germanium detectors, characterizing the volumetric plasma emission. The on-purpose developed collimation system was suitable for direct plasma density evaluation, performed on-line during beam extraction and charge state distribution characterization. A campaign for correlating the plasma density and temperature with the output charge states and the beam intensity for different pumping wave frequencies, different magnetic field profiles, and single-gas/gas-mixing configurations was carried out. The results reveal a surprisingly very good agreement between warm-electron density fluctuations, output beam currents, and ...
Cisplatin is a potent anti-cancer drug, which functions by cross-linking adjacent DNA guanine residues. However within one day of injection, 65~98% of the platinum in the blood plasma is protein-bound. It is generally accepted that cisplatin binds to methionine and histidine residues, but what is often underappreciated is that platinum from cisplatin has a 2+ charge and can form up to four bonds. Thus, it has the potential to function as a cross-linker. In this report, the cross-linking ability of cisplatin is demonstrated by Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS) with the use of standard peptides, the 16.8 kDa protein calmodulin (CaM), but was unsuccessful for the 64 kDa protein hemoglobin. The high resolution and mass accuracy of FTICR MS along with the high degree of fragmentation of large peptides afforded by collisionally activated dissociation (CAD) and electron capture dissociation (ECD) are shown to be a valuable means of characterizing cross-linking ...
Electron Induced dissociation (EID) is a method for fragmenting molecules species in mass spectrometry induced by interaction with (free) electrons (electron-induced dissociation, EID) at electron energies ranging from near 0 to >30 eV. The product-ion mass spectra exhibited EID originating from electronically excited even-electron precursor ions reduced radical cations formed by capture of low-energy electrons, and oxidized radical cations produced by interaction with high-energy electrons. Investigators have demonstrated that the spectra produced from high-energy EID EMS cell exhibit essentially the same qualitative structural information, i.e., amino acid side-chain (SC) losses and backbone cleavages, as observed with a Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometer. EMS cells incorporated into mass spectrometers could make tandem high-energy EID mass spectrometry more widely accessible for analysis of peptides, small singly charged molecules, pharmaceuticals, and ...
Dissociation of peptides induced by interaction with (free) electrons (electron-induced dissociation, EID) at electron energies ranging from near 0 to ,30 eV was carried out using a radio-frequency-free electromagnetostatic (EMS) cell retrofitted into a triple quadrupole mass spectrometer. The product-ion mass spectra exhibited EID originating from electronically excited even electron precursor ions, reduced radical cations formed by capture of low-energy electrons, and oxidized radical cations produced by interaction with high-energy electrons. The spectra demonstrate, within the limits of the triple quadrupoles resolving power, that high-energy EID product-ion spectra produced with an EMS cell exhibit essentially the same qualitative structural information, i.e. amino acid side-chain (SC) losses and backbone cleavages, as observed in high-energy EID spectra produced with a Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometer. The levels of fragmentation efficiency evident in ...
This course will introduce the basic concepts and terminology of mass spectrometry. The most important ionisation techniques used in mass spectrometry, including: electron ionisation, matrix assisted laser desorption/ionisation and atmospheric pressure ionisation techniques are introduced and details of the most common mass analysers including: quadrupoles, ion traps, time-of-flight (TOF), Orbitrap and Fourier-transform ion cyclotron resonance (FTICR) are provided.. The following topics are also covered: atomic and molecular masses, mass resolution, exact masses and isotopes, sample preparation, interfacing mass spectrometry with chromatographic techniques, ion detection, processing of mass spectral data, elementary spectral interpretation, and considerations for the mass spectrometry of large molecules. Using relevant, real-world examples such as common drugs and clinically relevant analytes, the course will illustrate both qualitative and quantitative applications of mass spectrometry.. The ...
The Cassady group uses mass spectrometry to study the gas-phase properties of biomolecules and to develop new techniques for analyzing these compounds. This work involves three higher performance mass spectrometers: a Bruker BioApex 7e Fourier transform ion cyclotron resonance spectrometer (FT-ICR or FTMS), a Bruker rapifleX dual time-of-flight (TOF-TOF) spectrometer (acquired in 2018), and a Bruker HCTultra PTM Discovery System high capacity quadrupole ion trap (QIT).. Our FT-ICR research deals with multiply-charged peptide and protein ions produced by electropsray ionization (ESI). Because FT-ICR is a trapping form of mass spectrometry, gas-phase biomolecular ions can be allowed to react with neutral molecules. The ions can also be fragmented, which is useful for obtaining structural information. Most of our recent work has centered on the reactivity and dissociation of deprotonated peptide ions. These ions are often formed in abundance from peptides with acidic residues, including phosphate ...
Autori: O. P. Balaj, C.-K. Siu, I. Balteanu, M. K. Beyer, and V. E. Bondybey. Editorial: Chem. Eur. J., 10, p.4822-4830, 2004.. Rezumat:. The gas-phase reactions of hydrated electrons with carbon dioxide and molecular oxygen were studied by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Both CO2 and O2 react efficiently with (H2O)n- because they possess low-lying empty pi* orbitals. The molecular CO2- and O2- anions are concurrently solvated and stabilized by the water ligands to form CO2-(H2O)n and O2-(H2O)n. Core exchange reactions are also observed, in which CO2-(H2O)n is transformed into O2-(H2O)n upon collision with O2. This is in agreement with the prediction based on density functional theory calculations that O2-(H2O)n clusters are thermodynamically favored with respect to CO2-(H2O)n. Electron detachment from the product species is only observed for CO2-(H2O)2, in agreement with the calculated electron affinities and solvation energies.. Cuvinte cheie: gas-phase ...
is the permeability of free space. Cyclotron radiation has a spectrum with its main spike at the same fundamental frequency as the particles orbit, and harmonics at higher integral factors. Harmonics are the result of imperfections in the actual emission environment, which also create a broadening of the spectral lines.[5] The most obvious source of line broadening is non-uniformities in the magnetic field;[6] as an electron passes from one area of the field to another, its emission frequency will change with the strength of the field. Other sources of broadening include collisional broadening[7] as the electron will invariably fail to follow a perfect orbit, distortions of the emission caused by interactions with the surrounding plasma, and relativistic effects if the charged particles are sufficiently energetic. When the electrons are moving at relativistic speeds, cyclotron radiation is known as synchrotron radiation. The recoil experienced by a particle emitting cyclotron radiation is ...
Background: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection.. Methods: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: 1 x 105 colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and ,1 x 105 CFU/mL (23 and 15 samples). BALF proteins were analyzed with SELDI-TOF mass spectrometry (MS) and H4 ProteinChips®. Proteins were identified and characterized using trypsin digestion, tandem MS, Fourier transform ion cyclotron resonance MS, immunoblotting, and ELISA.. Results: The SELDI-TOF MS BALF profiles contained 53 unique, reliably detected ...
Best Cyclotron Systems Inc. is presently developing a 70 MeV cyclotron for radioisotope production and research purpose. The RF system comprises two separated resonators driven by independent amplifiers to allow for the phase and amplitude modulation technique to be applied for beam intensity modulation. The resonators are presently in the commissioning phase consisting of cold test measurements followed by high power commissioning in the cyclotron. Preliminary simulation results have been reported and are: 56MHz operation (fourth harmonic, half-wave resonator design), 60 to 70kV dee voltage, quality factor 8000 with the estimated dissipated power of 17kW per resonator. The electromagnetic modeling has been done with CST Microwave Studio. All simulation results showed a very conservative design with typical parameters for the energy and size of the resonators. The paper will present the measurement results on a cold test set-up configuration as well as the commissioning with high power in the ...
A cyclotron that includes a magnet yoke having a yoke body that surrounds an acceleration chamber. The cyclotron also includes a magnet assembly to produce magnetic fields to direct charged particles along a desired path. The magnet assembly is located in the acceleration chamber. The magnetic fields propagate through the acceleration chamber and within the magnet yoke, wherein a portion of the magnetic fields escapes outside of the magnet yoke as stray fields. The cyclotron also includes a vacuum pump that is coupled to the yoke body. The vacuum pump is configured to introduce a vacuum into the acceleration chamber. The magnet yoke is dimensioned such that the vacuum pump does not experience magnetic fields in excess of 75 Gauss.
March 23, 1965 R. J. BURLEIGH ETAL MAGNET CONSTRUCTION FOR A VARIABLE ENERGY CYCLOIRON 2 Sheets-Sheet 1 Filed Feb. 8. 1961 POWER SUPPLY m 0 C H N G A M INVENTORS RICHARD J. BURLEGH ELMER L. KELLY BY JOSEPH H. DORST CHARLES a. DOLS /4 MQ-QM ATTORNEY March 23, 1965 J, BURLEIGH ETAL 3,175,131 MAGNET CONSTRUCTION FOR A VARIABLE ENERGY CYCLOTRON Filed Feb. 8, 1961 2 Sheets-Sheet 2 Useful Rad/us O Radius of Pale, I RADIAL POSITION 4 INVENTORS RICHARD J. BURLE/GH ELMER L. KELLY BY JOSEPH H. DORST CHARLES G. DOLS ATTORNEY United States Patent 0 MAGNET CQNSTRUCTEON FOR A VARIABLE ENERGY CYCLOTRON Richard J. Burleigh, Elmer L. Kelly, Joseph H. Durst, and Qharles G. Dole, all of Berkeley, Calif., assignors to the United States of America as represented by the United States Atomic Energy Commission Filed Feb. 8, 1961, Ser. No. 87,980 1% tllaims. (Cl. 317-458) This invention relates to charge particle accelerators and more particularly to magnetic pole pieces for cyclotrons and like accelerators which ...
Get information, facts, and pictures about Cyclotron at Encyclopedia.com. Make research projects and school reports about Cyclotron easy with credible articles from our FREE, online encyclopedia and dictionary.
We present timing and broad band spectral studies of the high-mass X-ray binary pulsar 4U 1909+07 using data from Suzaku observations during 2010 November 2-3. The pulse period of the pulsar is estimated to be 604.11 ± 0.14 s. Pulsations are seen in the X-ray light curve up to ∼70 keV. The pulse profile is found to be strongly energy-dependent: a complex, multi-peaked structure at low energy becomes a simple single peak at higher energy. We found that the 1-70 keV pulse-averaged continuum can be fit by the sum of a blackbody and a partial covering Negative and Positive power law with Exponential cutoff model. A weak iron fluorescence emission line at 6.4 keV was detected in the spectrum. An absorption-like feature at ∼44 keV was clearly seen in the residuals of the spectral fitting, independent of the continuum model adopted. To check the possible presence of a cyclotron resonance scattering feature (CRSF) in the spectrum, we normalized the pulsar spectrum with the spectrum of the Crab ...
The cyclotron is the only practical source of many carrier-free radioisotopes. The preparation and radiochemical isolation of a number of these activities, produced in the 60-inch cyclotron of Crocker Laboratory, will be presented in this paper and in subsequent papers of this series. In most cases the carrier-free radioisotopes were prepared for use in biological systems and the final preparations were in the form of isotonic saline solutions at a range of pH from 5 to 8. The present paper reports the radiochemical isolation of carrier-free Sn{sup 113} and In{sup 114} produced by bombarding cadmium with 38 Mev alpha-particles. At this energy, Sn{sup 113} and In{sup 114} are produced in a thick target by the nuclear reactions; Cd{sup 110}({alpha},n)Sn{sup 113}, Cd{sup 111}({alpha},2n)Sn{sup 113}, Cd{sup 112}({alpha},3n)Sn{sup 113}, Cd{sup 111}({alpha},p)In{sup 114}, Cd{sup 112}({alpha},pn) In{sup 114}. The shorter-lived tin and indium activities together with the possible radioisotopes of silver
However, it should be mentioned that the tracers often are relatively short-lived and need to be produced on-site (such as fluorine-18 with a half-life of just below 2 hours). The usual way of doing so is to use a cyclotron so, in a sense, the cyclotron is used indirectly to make positrons by creating the positron emitters ...
Cyclotrons[edit]. Lawrence's 60 inch cyclotron, with magnet poles 60 inches (5 feet, 1.5 meters) in diameter, at the University ... Main article: Cyclotron. The earliest operational circular accelerators were cyclotrons, invented in 1929 by Ernest Lawrence at ... An example of an isochronous cyclotron is the PSI Ring cyclotron in Switzerland, which provides protons at the energy of 590 ... so that their cyclotron frequency drops out of synch with the accelerating RF. Therefore, simple cyclotrons can accelerate ...
"Recent activities of the cyclotron laboratory in Nice" (PDF). Cyclotrons 1992. Vancouver, BC, Canada: JACoW. pp. 248-251. ... Moving to France in 1986 he helped the cancer hospital Centre Antoine Lacassagne in Nice to install a 65 MeV cyclotron for ...
small cyclotrons. 44Sc complexates with DOTA, a well-established bifunctional chelators conjugated to peptides or other ... 60 years provides a cyclotron-independent source of 44Sc for several decades. 44Ti is obtained in the nuclear reaction 45Sc(p, ... 44Sc in small cyclotrons. This isotope is of potential interest for clinical PET imaging. 44Ti with its long half-life of ca. ...
For instance, the very first cyclotron, built in 1932, was capable of producing 4.8 MeV in a device that fit on a tabletop. The ... "The First Cyclotrons". American Institute of Physics. Oliphant, Harteck & Rutherford 1934. Tuck 1958. Ruggiero 1992, p. 1. ...
Ion cyclotron resonance (ICR) is an older mass analysis technique similar to FTMS except that ions are detected with a ... Comisarow MB, Marshall AG (1974). "Fourier transform ion cyclotron resonance spectroscopy". Chemical Physics Letters. 25 (2): ... Orbitrap instruments are similar to Fourier transform ion cyclotron resonance mass spectrometers (see text below). Ions are ... Further information: Fourier transform ion cyclotron resonance. Fourier transform mass spectrometry (FTMS), or more precisely ...
The cyclotron is used for the production of fluorine-18, and is used for research purposes, particularly the development of ... "Cyclotron". McMaster University. 2011. Archived from the original on 22 July 2011. Retrieved 21 January 2011. "Member Libraries ... The university provides a wide range of irradiation, laboratory, and holding facilities, which include a cyclotron, an ...
Cyclotron A cyclotron is a type of particle accelerator invented by Ernest O. Lawrence in 1929-1930 at the University of ... A cyclotron accelerates charged particles outwards from the center along a spiral path. The particles are held to a spiral ... "Ernest Lawrence's Cyclotron". www2.lbl.gov. Retrieved 2018-04-06. "Ernest Lawrence - Biographical". nobelprize.org. Retrieved ... Nave, C. R. (2012). "Cyclotron". Dept. of Physics and Astronomy, Georgia State University. Retrieved October 26, 2014. Close, F ...
After Cyclotron was released, the members began pursuing their own separate musical endeavors. Andy Hawkins began a solo guitar ... They also announced plans to re-issue Cyclotron. Though at its core heavy metal, Blind Idiot God's music is informed by punk ... "Cyclotron". Allmusic. Retrieved September 22, 2014. Shrum (February 24, 2015). "Blind Idiot God's 'Before Ever After' Out Today ... the band's 1992 album Cyclotron was seen by some as lackluster due to the reliance on idea previously explored and absence of ...
"Zirconium-89 (89Zr)". Cyclotron.nl. 93Zr is a radioisotope of zirconium with a half-life of 1.53 million years, decaying ...
The company was part of Lawrence Berkeley National Laboratory's first Cyclotron Road cohort, an incubator program that aids in ... CS1 maint: discouraged parameter (link) "All Projects: Alumni". Cyclotron Road. Satell, Greg (April 5, 2018). "Why Some of the ...
Most installed proton therapy systems utilise isochronous cyclotrons. Cyclotrons are considered simple to operate, reliable and ... One hindrance to universal use of the proton in cancer treatment is the size and cost of the cyclotron or synchrotron equipment ... "Cyclotron Services". crocker.udavis.edu. University of California, Davis, Crocker Nuclear Laboratory. Retrieved 2017-10-05. " ... The world's first hospital-based proton therapy center was a low energy cyclotron centre for ocular tumours at the ...
Dunning closely followed the work of Ernest Lawrence on the cyclotron. Dunning wanted a more powerful neutron source and the ... Nonetheless, during 1935 and 1936 he was able construct a cyclotron using many salvaged parts to reduce costs and funding from ... Wade, Elizabeth (4 February 2008). "Cyclotron Scrapped". Columbia Daily Spectator. Hahn, O.; Strassmann, F. (1939). "Über den ... cyclotron appeared as an attractive tool to achieve this end. Government funding was not available for such projects in those ...
"Cyclotron Road's Etosha Cave Recognized as one of Vanity Fair's 26 Women of Color Diversifying Entrepreneurship". Energy.gov. ... Opus 12 was awarded the Forbes magazine Change the World Award and was selected for the Advanced Manufacturing Office Cyclotron ... "Watch: Etosha Cave speaks at TEDx Stanford". Cyclotron Road. Retrieved 2019-07-16. "Opus 12". Elemental Excelerator. Retrieved ...
Basically, it consists of three accelerators in series: the Cockcroft-Walton, the injector-2 cyclotron, and the ring-cyclotron ... while the main part is fed into the Ring Cyclotron for further acceleration. Like the Injector-2, the Ring Cyclotron, which has ... The new cyclotron has enabled an increase in the beam current from 1 to 2 mA, which was the absolute record value for the 1980s ... 200 to 186, and the distance travelled by the protons in the cyclotron decreased from 6 km to 4 km. With a beam current of 2.2 ...
... cyclotron.tamu.edu. Texas A & M University. Retrieved 30 October 2018. see Flerov lab annual reports 2000-2004 inclusive http ...
An electron cyclotron resonance heating (ECRH) system that will heat electrons in the plasma using a high-intensity beam of ... An ion cyclotron resonance heating (ICRH) system that will inject 20 MW of electromagnetic power into the plasma by using ... "Electron Cyclotron Heating". US ITER. Oak Ridge, Tennessee: US ITER. Retrieved 20 March 2021. "Cryostat". Retrieved 2 April ...
Darleane (Christian) Hoffman bio page Archived 2010-06-12 at the Wayback Machine, Cyclotron Institute, Texas A&M University ... "Darleane (Christian) Hoffman - SJY Group". cyclotron.tamu.edu. Retrieved 2020-05-13. ...
Roberto, JB (2015). "Actinide Targets for Super-Heavy Element Research" (PDF). cyclotron.tamu.edu. Texas A & M University. ... cyclotron.tamu.edu. Texas A & M University. Retrieved 30 October 2018. Zagrebaev, Karpov & Greiner 2013. Rykaczewski, Krzysztof ...
In 1956, a team of six students designed and began construction of a cyclotron. A low-power test of the device succeeded six ... "The Cyclotron Committee". The Campaign for Stuyvesant. March 27, 2007. Archived from the original on September 28, 2007. ...
It centered physics research around his new instrument, the cyclotron, a type of particle accelerator for which he was awarded ... "The Rad Lab - Ernest Lawrence and the Cyclotron". American Institute of Physics. Retrieved April 18, 2016. Heilbron, J. L.; ... University of California , Office of the President (accessed July 15, 2013). "Ernest Lawrence's Cyclotron". Lbl.gov. August 27 ... The cyclotron, whose construction was stalled during the war, was finished in November 1946. The Manhattan Project shut down ...
1 Cyclotron Road • Berkeley, CA 94720.CS1 maint: location (link) Alm, E. J.; Huang, K. H.; Price, M. N.; Koche, R. P.; Keller, ... 1 Cyclotron Road • Berkeley, CA 94720.CS1 maint: location (link) Dehal, P. S.; Joachimiak, M. P.; Price, M. N.; Bates, J. T.; ... 1 Cyclotron Road • Berkeley, CA 94720.CS1 maint: location (link) Kanehisa, M. (2004). "The KEGG resource for deciphering the ...
The RIKEN experiment began by being conducted at a cyclotron while it upgraded its linear accelerators; the upgrade was ... Roberto, J. B. (31 March 2015). "Actinide Targets for Super-Heavy Element Research" (PDF). cyclotron.tamu.edu. Texas A & M ...
Roberto, J. B. (31 March 2015). "Actinide Targets for Super-Heavy Element Research" (PDF). cyclotron.tamu.edu. Texas A & M ...
Roberto, J. B. (31 March 2015). "Actinide Targets for Super-Heavy Element Research" (PDF). cyclotron.tamu.edu. Texas A & M ... cyclotron.tamu.edu. Texas A & M University. Retrieved 30 April 2017. Folden III, C. M.; Mayorov, D. A.; Werke, T. A.; et al. ( ...
Roberto, J. B. (2015). "Actinide Targets for Super-Heavy Element Research" (PDF). cyclotron.tamu.edu. Texas A & M University. ... cyclotron.tamu.edu. Texas A & M University. Retrieved 30 October 2018. Zagrebaev, Karpov & Greiner 2013 see Flerov lab annual ...
The cyclotron was ordered from the Soviet Union in 1985 and constructed between 1987 and 1990. It is used for student training ... "MGC-20 Cyclotron". NTI.org. Archived from the original on 17 November 2015. Retrieved 20 April 2015. "Pyongyang City People's ... Sosong-guyok hosts a 20 MeV cyclotron called MGC-20. The initial project was approved by the International Atomic Energy Agency ...
Eichler, Robert (2015). "Gas phase chemistry with SHE - Experiments" (PDF). cyclotron.tamu.edu. Texas A & M University. ...
The 27-inch cyclotron was superseded by a 37-inch cyclotron in June 1937, which in turn was superseded by a 60-inch cyclotron ... The result was the first cyclotron. Lawrence went on to build a series of ever larger and more expensive cyclotrons. His ... the mass spectrometer and cyclotron. The name was derived from "California university cyclotrons". In November 1943, Lawrence's ... Their first cyclotron was made out of brass, wire, and sealing wax and was only four inches (10 cm) in diameter-it could ...
"A Cyclotron's Story". Retrieved 2 November 2017. "Building the Cyclotron". Retrieved 2 November 2017. Williams, L.N. & M. (1949 ... This laboratory became home to the Berkeley 60" cyclotron. In the 1960s, parts of this cyclotron were moved to the University ... Crocker cyclotron used for neutron therapy at Berkeley. Crocker also chaired the Panama-Pacific Exposition Committee and SE ...
From 1948 to 1950, he was a research fellow at Caltech, where he learned cyclotron design and instrumentation from working with ... Lind and Jack J. Kraushaar were the faculty leaders for developing and operating the University of Colorado Cyclotron. They ... ISBN 978-0-309-03099-1. (See p. 182.) "Colorado Cyclotron Facility". Physics Today. 16 (5): 94. 1963. doi:10.1063/1.3050950. ... were the principal investigators of an AEC contract for designing and constructing a 52-inch cyclotron with azimuthally varying ...
Rutgers Cyclotron-Students at Rutgers University built a 30 cm (12 in) 1 MeV cyclotron as an undergraduate project, which is ... Cyclotrons have a single electrical driver, which saves both money and power. Furthermore, cyclotrons are able to produce a ... Examples of isochronous cyclotrons abound; in fact almost all modern cyclotrons use azimuthally-varying fields. The TRIUMF ... Jardin, X. (12 Jan 2005). "The Cyclotron Comes to the Hood". Wired. About a neighborhood cyclotron in Anchorage, Alaska.CS1 ...
A cyclotron is a type of particle accelerator. Cyclotron may also refer to: Cyclotron resonance, a phenomenon observed both in ... Cyclotron (comics), a minor character in the DC Universe Cyclotron (album), a 1993 album by the rock band Blind Idiot God the ... in Belgium This disambiguation page lists articles associated with the title Cyclotron. If an internal link led you here, you ... Louvain-la-Neuve Cyclotron, a particle accelerator and building of the University of Louvain (UCLouvain) ...
The Centre consists of major facilities such as K130 Cyclotron, K500 Superconducting Cyclotron, Cyclone-30 Medical Cyclotron, ... The Variable Energy Cyclotron Centre (VECC) is a research and development unit of the Department of Atomic Energy. The VECC is ... It has a collaboration with the European Organization for Nuclear Research.[2] The Centre houses a 224 cm cyclotron-the first ... "Variable Energy Cyclotron Centre, Kolkata". Homi Bhabha National Institute. Retrieved 1 April 2014.. ...
Lastly, our cyclotrons are built for reliability with an unmatched, guaranteed uptime and backed by the largest footprint of ... This highly versatile cyclotron can be configured in a number of different ways. By selecting different target systems and ... To go in search of true discovery with PET, access to a cyclotron is necessary, and yet they are considered the most difficult ... This, together with a high production capacity, has made it one of the most preferred cyclotrons in the world. The PETtrace 800 ...
This publication contains radioisotope decay and production details of 49 isotopes that can be prepared using cyclotrons. The ... INTERNATIONAL ATOMIC ENERGY AGENCY, Cyclotron Produced Radionuclides: Physical Characteristics and Production Methods, ... and a major factor contributing towards this growth is the availability of a large number of cyclotrons dedicated to the ... introductory chapter discusses the principles of radioisotope production using cyclotrons, and the publication contains data on ...
Make research projects and school reports about Cyclotron easy with credible articles from our FREE, online encyclopedia and ... Cyclotron Dictionary of American History COPYRIGHT 2003 The Gale Group Inc.. CYCLOTRON. CYCLOTRON, a machine for accelerating ... Cyclotron How Products Are Made COPYRIGHT 1996 Gale Research Inc.. Cyclotron. Background. The modern cyclotron uses two hollow ... More powerful cyclotron units are being designed for commercial isotope production. The latest series of cyclotrons are state ...
Cyclotron Building. The Cyclotron Building was completed in 1941.. The building was constructed under the recommendation of ... The original cyclotron was an 80-ton machine that was used to isolate the worlds first plutonium. ...
... from the injector cyclotron (JULIC) of the COSY storage ring. Recently a high performance cyclotron from IBA was acquired which ... Cyclotron. Usually, all radionuclides applied in molecular imaging have to be produced at an accelerator. ... The cyclotron is a circular accelerator, which accelerates charged particles to high energies (up to 16 MeV). ... The operating principle of the cyclotron is based on the electro-magnetic acceleration of charged particles, like ions of ...
Combined with our 7-T small-bore MRI scanner, our on-site cyclotron, radiochemistry, and HPLC facilities, we offer the best ... PET Tracers Please contact the Director of Cyclotron to inquire about the production of other tracers not featured in the list ... Christian Janicki Administrative Coordinator Belinda Preziosi Our PET and Cyclotron staff is supported in part by a generous ... Cyclotron Dean Jolly Systems Manager Reda Bouhachi Research Assistants Marina Kostikova Karen Ross Monica Samoila-Lactatus ...
Cyclotron Radiochemistry Facility. Facility & Equipment. The Cyclotron Radiochemistry Facility (CRF) occupies 13,000 square ... Greg Waligorski, MPM - Cyclotron Engineering Specialist. Julius Balatoni, Ph.D. - Lab Manager. James Carl, B.S. - Radiochemist ...
Tucked away behind a large concrete door in the Wallace Tumor Institute is a cyclotron, a blue 61,000-pound machine that was ... Cyclotrons impact. One major way the cyclotron will play such a big role in transforming UAB and Birmingham is by producing ... The cyclotron is one of the most powerful machines of its type in the country, UAB officials say, and its in the heart of ... UABs cyclotron is still about a month out from use, but cancer center officials and people familiar with medical research say ...
Ge PET Cyclotron Pettrace Model Information: The PETtrace tracer production system is a compact, automated cyclotron designed ... The PETtrace tracer production system is a compact, automated cyclotron designed for the fast, easy and efficient production of ... Find All Used, New, and Refurbished GE PETtrace* PET Cyclotron For Sale Listings on DOTmed ...
The Indiana University Health Proton Therapy Center and IU Cyclotron in Bloomington will close by the end of the year, costing ... The Indiana University Health Proton Therapy Center and IU Cyclotron in Bloomington will close by the end of the year, costing ... dedication and passion of the IUHPTC and IU Cyclotron staff, said Dr. Jay Hess, vice president for university clinical affairs ...
Magnetic field adjusting center rods for cyclotron a magnet for cyclotron, and cyclotron. ... Magnetic field adjusting center rods for cyclotron, magnet for cyclotron, and cyclotron. ... A cyclotron using the azimuthally varying field is disclosed, for example, in US. Patent No. 2,872,574, Cloverleaf Cyclotron, ... In a cyclotron a pair of spaced apart magnet poles are used to provide a field for holding particles in a curvilinear orbit. In ...
The cyclotron also includes a vacuum pump that is coupled to the yoke body. The vacuum pump is configured to introduce a vacuum ... The cyclotron also includes a magnet assembly to produce magnetic fields to direct charged particles along a desired path. The ... A cyclotron that includes a magnet yoke having a yoke body that surrounds an acceleration chamber. ... As shown, the cyclotron 502 has similar features and components as the cyclotron 200 (. FIG. 2. ). However, the cyclotron 502 ...
Cyclotron AVF Cyclotron Ring Cyclotron Linac Ion Linac Small Ion Linac SR ring Aurora2D ... Cyclotron. The cyclotron is facilities to accelerate by an electric field by the high frequency that synchronized for the ... Ring Cyclotron A kind of AVF cyclotron, the magenets are designed radially separated several sectors. ... AVF Cyclotron AVF is abbreviation of Azimuthally Varying Field that means the magnetic field change with alternate strong and ...
Productions Based on a High-Performance Cyclotron. J. Esposito,1 G. Vecchi,1,2 G. Pupillo,2 A. Taibi,2 L. Uccelli,3 A. Boschi,3 ... Moreover, in vivo biodistribution studies in rats were performed, using the cyclotron-produced -BRIDA pharmaceutical, whose ... MIBI were above the USP requirements (,90%), and identical patterns were found for the cyclotron- and the generator-produced ... J. E. Beaver and H. B. Hupf, "Production of 99mTc on a medical cyclotron: a feasibility study," Journal of Nuclear Medicine, ...
Productions Based on a High-Performance Cyclotron. J. Esposito,1 G. Vecchi,1,2 G. Pupillo,2 A. Taibi,2 L. Uccelli,3 A. Boschi,3 ... J. E. Beaver and H. B. Hupf, "Production of 99mTc on a medical cyclotron: a feasibility study," Journal of Nuclear Medicine, ... K. Gagnon, F. Bénard, M. Kovacs et al., "Cyclotron production of 99mTc: experimental measurement of the 100Mo(p,x) 99Mo, 99mTc ... K. Gagnon, J. S. Wilson, C. M. B. Holt et al., "Cyclotron production of 99mTc: recycling of 100Mo metal targets," Applied ...
The AHS Class II license for the PET Cyclotron operates under an operating license issued by the Canadian Nuclear Safety ... AHS PET Cyclotron Public Disclosure. The AHS Class II license for the PET Cyclotron operates under an operating license issued ... The PET Cyclotron is currently operational. The Cyclotron facility reported an unplanned release of carbon dioxide gas on ... the Cross Cancer Institute and the Medical Isotope and Cyclotron Facility (MICF) at U of A South Campus. These cyclotrons are ...
As a cyclotron isotope expert, you will primarily be part of the research program at the Hevesy Laboratory. You will join the ... Cyclotron and Radionuclide Production Engineer within Biomedical Radiochemistry DTU Nutech Del til Facebook ... Ad-Hoc cyclotron experimental and technical support. *Production of novel and hard-to-get isotopes at foreign reactors and high ... The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes, both for PET scans ...
The AHS Class II license for the PET Cyclotron operates under an operating license issued by the Canadian Nuclear Safety ... AHS PET Cyclotron Public Disclosure. The AHS Class II license for the PET Cyclotron operates under an operating license issued ... The PET Cyclotron is currently operational. The Cyclotron facility reported an unplanned release of carbon dioxide gas on ... Contact: cyclotron[email protected] Background. There are currently two cyclotron facilities in Edmonton that produce ...
Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of Fluorodeoxyglucose (FDG). ... Cyclotron Produced Radionuclides: Emerging Positron Emitters for Medical Applications: 64Cu and 124I. ... Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of Fluorodeoxyglucose (FDG) ... INTERNATIONAL ATOMIC ENERGY AGENCY, Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of ...
... Mass Spectrom Rev. Jan-Feb 1998;17(1):1-35. doi: 10.1002 ... Topics include: effect of ion mass, charge, magnetic field, and trapping voltage on ion cyclotron frequency; excitation and ...
Cyclotron Facility Director. Director, Division of Advanced Medical Imaging Research. Professor, Department of Radiology and ...
The cyclotron is a core piece of equipment of the system and its installation marks a key milestone for NTUCC, as the first ... Installation marks milestone for first ProBeam system in Taiwan Varian announced the installation of the cyclotron for its ... Varian Installs Cyclotron at National Taiwan University Cancer Center , Varian. Skip to main content ... Varian announced the installation of the cyclotron for its ProBeam® proton therapy system at the National Taiwan University ...
Electron cyclotron current drive is a key option for driving current off-axis in a tokamak, as needed for example for current ... Electron cyclotron current drive is a key option for driving current off-axis in a tokamak, as needed for example for current ... Electron cyclotron current drive is a key option for driving current off-axis in a tokamak, as needed for example for current ... PRATER, R.; PETTY, C.C.; HARVEY, R.; LIN-LIU, Y.R.; LOHR, J.M. & LUCE, T.C. PHYSICS OF OFF-AXIS ELECTRON CYCLOTRON CURRENT ...
A group of almost 30 scientists and engineers from six research institutions reported the direct detection of cyclotron ... Electron chirp: Cyclotron radiation from single electrons measured directly for first time Method has potential to measure ... Electron chirp: Cyclotron radiation from single electrons measured directly for first time. DOE/Pacific Northwest National ... A group of almost 30 scientists and engineers from six research institutions reported the direct detection of cyclotron ...
D. G. Lominadze, Cyclotron Waves in Plasmas [in Russian], Metsikereba, Tbilisi (1975), p. 233.Google Scholar ... Magnetic Field Shock Wave Fluid Dynamics Analytic Study Electron Cyclotron Translated from Izvestiya Akademii Nauk SSSR, ... Effect of electron cyclotron waves on the structure of a weak collisionless shock wave. ... Dissipation is produced by an instability associated with electron cyclotron oscillations.. Keywords. ...
... Author(s). Smith, D.K.; Brau, K.; Goodrich, P.; ...
A cyclotron is a type of particle accelerator. The first was built in the late 1920s. They exist around the world are used to ... Cyclotrons in the Modern Age. Today, cyclotrons are still used for certain areas of medical research, and range in size from ... The largest cyclotrons are the TRIUMF 500 MeV Cyclotron, which is still in operation at the University of British Columbia in ... "The Cyclotron and Particle Physics." ThoughtCo, Nov. 27, 2017, thoughtco.com/what-is-a-cyclotron-2699099. Jones, Andrew ...
  • The Cyclotron facility reported an unplanned release of carbon dioxide gas on August 31, 2017. (albertahealthservices.ca)
  • The report then estimates 2017-2022 market development trends of Medical Cyclotron industry. (researchmoz.us)
  • The worldwide market for Medical Cyclotron is expected to grow at a CAGR of roughly 4.5% over the next five years, will reach 130 million US$ in 2023, from 100 million US$ in 2017, according to a new GIR (Global Info Research) study. (reportsnreports.com)
  • (Richmond, BC) - Advanced Cyclotron Systems, Inc. (ACSI) is pleased to announce that it will attend the 30th Annual Congress of the European Association of Nuclear Medicine, October 21-24, 2017. (advancedcyclotron.com)
  • Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid v. (nih.gov)
  • We have characterized the synthesized model HS using high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS), 1 H NMR spectroscopy, and controllable hydrogen/deuterium (H/D) exchange. (rsc.org)
  • It was shown that it is possible to analyze complex mixtures of protein tryptic digests by direct infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and identify abundant proteins by peptide mass fingerprinting. (diva-portal.org)
  • However, increasing demands of biotechnological applications require further progress to be made.In the present thesis the development and improvement of peptide and protein characterization methods and techniques based on ion-electron and ion-photon reactions in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry are described. (dissertations.se)
  • In this study, a reliable and sensitive ultra‐high performance liquid chromatography coupled with fourier transform ion cyclotron resonance mass spectrometry method was developed for the systematic study of the metabolic profile of Kudiezi injection in rat plasma, bile, urine, and feces after intravenous administration of a single dose. (separationsnow.com)
  • A typical application of this type of traps is ion cyclotron resonance mass spectrometry (ICR-MS). Analytical expressions for the potentials of common traps are derived, and used to study the dynamics of simultaneously stored positive and negative ions. (uni-bremen.de)
  • Close to 1500 cyclotrons are used in nuclear medicine worldwide for the production of radionuclides. (wikipedia.org)
  • INTERNATIONAL ATOMIC ENERGY AGENCY, Cyclotron Produced Radionuclides: Physical Characteristics and Production Methods, Technical Reports Series No. 468, IAEA, Vienna (2009). (iaea.org)
  • INTERNATIONAL ATOMIC ENERGY AGENCY, Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of Fluorodeoxyglucose (FDG), Radioisotopes and Radiopharmaceuticals Series No. 3, IAEA, Vienna (2012). (iaea.org)
  • In January 1929, Szilárd became the first person to discuss the resonance condition (what is now called the cyclotron frequency) for a circular accelerating apparatus, in a patent application in Germany. (wikipedia.org)
  • A cyclotron accelerates a charged particle beam using a high frequency alternating voltage which is applied between two hollow "D"-shaped sheet metal electrodes called "dees" inside a vacuum chamber. (wikipedia.org)
  • To achieve this, the frequency must match the particle's cyclotron resonance frequency f = q B 2 π m {\displaystyle f={\frac {qB}{2\pi m}}} , where B is the magnetic field strength, q is the electric charge of the particle and m is the relativistic mass of the charged particle. (wikipedia.org)
  • The earliest cyclotron was very small, using electrodes, a radio frequency oscillator producing 10 watts, a vacuum, hydrogen ions, and a 4 in (10 cm) electromagnet. (encyclopedia.com)
  • The cyclotron is facilities to accelerate by an electric field by the high frequency that synchronized for the turning of a charged particle tracing the spiral orbit in a perpendicular plane in the magnetic static field direction. (shi.co.jp)
  • In this study, a reduced model of quasilinear velocity diffusion by a small Larmor radius approximation is derived to couple the Maxwell's equations and the Fokker Planck equation self-consistently for the ion cyclotron range of frequency waves in a tokamak. (osti.gov)
  • Ion cyclotron resonance frequency heating (ICRH) is one of the most important mechanisms to heat fusion plasma. (upc.edu)
  • Therefore, ions revolve around the magnetic field lines in a determined frequency, the so called ion cyclotron frequency. (upc.edu)
  • ICRH is based on launching electromagnetic waves from the low-field side in such a way that their frequency matches the one from ions cyclotron frequency. (upc.edu)
  • The cyclotron frequency of the electron beam is 1THz, but the frequency regime of the SPPs and the radiation are much higher, up to hundreds of terahertz. (edu.au)
  • The Effect of Electromagnetic Fields with the Mg2+ Cyclotron Frequency on Mouse Reproductive Performance. (emf-portal.org)
  • The applied frequency (about 60 Hz ) matches the cyclotron frequency of Mg 2+ . (emf-portal.org)
  • Application of radioisotopes has shown significant growth in the past decade, and a major factor contributing towards this growth is the availability of a large number of cyclotrons dedicated to the production of radioisotopes for medical applications. (iaea.org)
  • 3. The cyclotron of claim 1 wherein an average magnetic field between the pole tops when the cyclotron is used to produce radioisotopes is at least 1 Tesla. (google.es)
  • These cyclotrons are similar devices but can produce different radioisotopes, offering a more diverse suite of radiopharmaceuticals for medical diagnosis and research. (albertahealthservices.ca)
  • The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes, both for PET scans ( 18 F, 64 Cu, 89 Zr, 52 Mn) and internal radiotherapy. (dtu.dk)
  • There are currently two cyclotron facilities in Edmonton that produce radiopharmaceuticals for medical use: the Edmonton PET Centre at the Cross Cancer Institute (AHS) and the Medical Isotope and Cyclotron Facility (MICF) at Balmoral (U of A). These cyclotrons are similar devices but can produce different radioisotopes, offering a more diverse suite of radiopharmaceuticals for medical diagnosis and research. (albertahealthservices.ca)
  • Carrier-free radioisotopes from cyclotron targets. (upenn.edu)
  • The cyclotron is the only practical source of many carrier-free radioisotopes. (unt.edu)
  • This cyclotron produces a variety of proton-induced medical radioisotopes that are widely used in diagnostic and therapeutic investigations and procedures. (einpresswire.com)
  • Many cyclotrons have limitations in energy or intensity for the production of SPECT radioisotopes. (isosolutions.com)
  • A cyclotron accelerates charged particles outwards from the center of a flat cylindrical vacuum chamber along a spiral path. (wikipedia.org)
  • The cyclotron is a circular accelerator, which accelerates charged particles to high energies (up to 16 MeV). (fz-juelich.de)
  • The operating principle of the cyclotron is based on the electro-magnetic acceleration of charged particles, like ions of hydrogen, deuterium ("heavy hydrogen") or helium. (fz-juelich.de)
  • The cyclotron also includes a magnet assembly to produce magnetic fields to direct charged particles along a desired path. (google.es)
  • For that, they devised the cyclotron, a type of particle accelerator that uses a constant magnetic field to hold charged particles as they move faster and faster in a circular spiral pattern. (thoughtco.com)
  • Stable, non-radioactive isotopes are put into the cyclotron which accelerates charged particles to high energy in a magnetic field. (reportsnreports.com)
  • Browsing IU Cyclotron Facility by Author "Hyde, C. (iu.edu)
  • When they reach the rim a small voltage on a metal plate deflects the beam so it exits the dees through a small gap between them, and hits a target located at the exit point at the rim of the chamber, or leaves the cyclotron through an evacuated beam tube to hit a remote target. (wikipedia.org)
  • The Centre consists of major facilities such as K130 Cyclotron, K500 Superconducting Cyclotron, Cyclone-30 Medical Cyclotron, Radioactive Ion Beam (RIB) Facility, Computing Centre, Regional Radiation Medicine Centre and a new Campus for the proposed ANURIB project [4] [5] at New Town, Rajarhat. (wikipedia.org)
  • 99%) molybdenum metallic targets, bombarded with high-beam-current, high-energy proton cyclotrons. (hindawi.com)
  • As an injector ion source for the 88-Inch Cyclotron, the design objective is the production of very high charge state beam (U 48+ , Xe 44+ ). (lbl.gov)
  • The first scheduled experiment with a rare-isotope beam produced by the coupled cyclotrons, separated with the A1900, thermalized in N4, charge-bred in the EBIT and then reaccelerated by ReA3 was used to carry out an experiment with the AT-TPC. (msu.edu)
  • The present invention relates to ion-beam technology, in particular, to electron-cyclotron resonance type ion beam sources for use in ion implanters. (google.com)
  • The size of a family car and weighing the same as seven London buses, the cyclotron is the beating heart of the proton beam therapy centre at UCLH, being delivered by Bouygues UK. (bouygues-uk.com)
  • The stable isotopes then react with a beam to form radioactive isotopes, which are then taken from the cyclotron, transformed into positron-emitting radiopharmaceuticals (PERs) within the facility s laboratories and are delivered to nuclear medicine where they are used for imaging procedures. (reportsnreports.com)
  • PT2026 to map a superconducting cyclotron A compact particle accelerator that allows the particle beam to spiral out as it gains energy. (metrolab.com)
  • to precisely measure the field at the cyclotron A compact particle accelerator that allows the particle beam to spiral out as it gains energy. (metrolab.com)
  • Cyclotron electron beam excited surface plasmon polaritons coherent ra" by Sen Gong, Tao Zhao et al. (edu.au)
  • Here SPPs on the circular cylindrical structures are excited by a cyclotron electron beam (CEB) rather than by the linearly moving electron beam (LEB). (edu.au)
  • In mid-June, the team was able to produce the first beam from the cyclotron. (nd.edu)
  • To tune the beam into the cave, protons generated at our ion source are accelerated through the Cyclotron and tuned down the beamline. (lbl.gov)
  • In particular, the acceleration of deuterium beam ions above the injection energy by absorption of ion cyclotron waves at the 2nd harmonic is investigated and compared to theoretical predictions by the TORIC-SSFPQL and TORIC-NUBEAM code packages. (dtu.dk)
  • A recent DIII-D experiment investigating the impact of electron cyclotron heating (ECH) on neutral beam driven reversed shear Alfvén eigenmode (RSAE) activity is presented. (escholarship.org)
  • With the end goal of making true discovery possible for more healthcare providers, each system in our portfolio of cyclotrons is designed to make it easier to implement and operate a tracer production facility. (gehealthcare.com)
  • The Cyclotron Radiochemistry Facility (CRF) occupies 13,000 square feet of dedicated laboratory for the manufacturing of PET radiopharmaceuticals under cGMP. (mdanderson.org)
  • Tucked away behind a large concrete door in the Wallace Tumor Institute is a cyclotron, a blue 61,000-pound machine that was lowered by a crane into the basement floor of the downtown Birmingham facility in the spring. (bizjournals.com)
  • The molecules made by the cyclotron have a large demand in health care and puts a research university on the map, said Sam Sadeghi , director of the Ahmanson Biomedical Cyclotron Facility at the University of California Los Angeles. (bizjournals.com)
  • There are currently two AHS cyclotrons in Edmonton that produce radiopharmaceuticals for medical use located at: the Cross Cancer Institute and the Medical Isotope and Cyclotron Facility (MICF) at U of A South Campus. (albertahealthservices.ca)
  • The arrival of the cyclotron represents the technical 'heart' of our proton therapy center and ushers in a new generation of radiation therapy, unsurpassed by any other facility in Northern Virginia. (iba-worldwide.com)
  • At Advanced Cyclotron Systems, Inc. (ACSI), we work closely with our customers throughout the entire project lifecycle - starting from facility design, equipment installation, radioisotope and radiopharmaceutical production, quality assurance , and regulatory advice - to the delivery of the final radiopharmaceutical dose. (advancedcyclotron.com)
  • Pre-training of your staff begins at our facility during the final testing period of your cyclotron system. (advancedcyclotron.com)
  • Training continues at your facility after your cyclotron system is installed and lasts approximately one month. (advancedcyclotron.com)
  • The cyclotron facility in Beacon is a GMP (Good Manufacturing Practice) certified facility by NPRA (National Pharmaceutical Bureau Agency, Malaysia) and therefore is licensed to supply FDG nationwide. (beaconhospital.com.my)
  • The capacity of the Cyclotron Center of Nuclear Medicine of the Ural Federal University will help increase the production of radiopharmaceuticals for expanding the PET/CT diagnostics program in the Sverdlovsk Region. (indiaeducationdiary.in)
  • By the end of 2021, the University Cyclotron Center for Nuclear Medicine will begin industrial production of radiopharmaceuticals, primarily 18F-fluorodeoxyglucose, which is used in the vast majority of PET studies and allows detecting malignant tumors of many organs," said Viсtor Koksharov. (indiaeducationdiary.in)
  • The capabilities of the Ural Federal University cyclotron center will allow the production of other in-demand radiopharmaceuticals for the diagnosis of other diseases, including, for example, Parkinson's disease, cardiovascular pathologies and others. (indiaeducationdiary.in)
  • We present the first results from a new electrospray ionization Fourier transform ion cyclotron resonance mass spectrometer operated at a magnetic field of 9.4 T (i.e. (nih.gov)
  • Collision Cross Sectional Areas from Analysis of Fourier Transform Ion Cyclotron Resonance Linewidth: a New Method for Characterizing Molecular Structure. (biomedsearch.com)
  • We demonstrate a technique for determining molecular collision cross sections via measuring the variation of Fourier transform ion cyclotron resonance (FTICR) linewidth with background damping gas pressure, under conditions where the length of the FTICR transient is pressure limited. (biomedsearch.com)
  • Electron capture dissociation of the peptide Substance P is reported for the first time, with an unmodified, commercially available Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. (diva-portal.org)
  • Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. (diva-portal.org)
  • A hybrid linear ion-trap Fourier-transform ion cyclotron resonance mass spectrometer was used for top-down characterization of the abundant human salivary Cystatins, including S, S1, S2, SA, SN, C, and D , using collisionally activated dissociation (CAD) after chromatographic purification of the native, disulfide intact proteins from saliva. (pubmedcentralcanada.ca)
  • The positive- and negative-ion laser desorption ionization Fourier transform ion cyclotron resonance mass spectra of two known, underivatized, linear oligosaccharides obtained by enzymatic hydrolysis with bacterial viruses of the corresponding native bacterial capsular polysaccharides were analyzed. (ubc.ca)
  • Structural information obtained by negative-ion laser desorption ionization Fourier transform ion cyclotron resonance (l.d.i. (ubc.ca)
  • Cyclotron and intersubband resonances in HgTe quantum wells in the inverted band regime are studied by Fourier-transform spectroscopy. (uni-regensburg.de)
  • The ion source uses a tungsten filament to energize the hydrogen gas and borated polyethylene packing is used to reduce the build up of thermal neutrons around components of the cyclotron. (encyclopedia.com)
  • Your staff will learn about the operations, sub-systems and components of the cyclotron system. (advancedcyclotron.com)
  • Cyclotron production of 99m Tc: an approach to the medical isotope crisis," Journal of Nuclear Medicine , vol. 51, no. 4, pp. (hindawi.com)
  • As a cyclotron isotope expert, you will primarily be part of the research program at the Hevesy Laboratory. (dtu.dk)
  • The TR-19, TR-24, the new TR-FLEX, and TR-30 cyclotrons generate the highest current output and offer unsurpassed isotope production yields compared to other cyclotrons on the market. (advancedcyclotron.com)
  • Recently a high performance cyclotron from IBA was acquired which will be in operation in 2018. (fz-juelich.de)
  • Advanced Cyclotron Systems, Inc. is a world leader in the design and manufacturing of cyclotrons. (advancedcyclotron.com)
  • Electron cyclotron current drive is a key option for driving current off-axis in a tokamak, as needed for example for current profile control or for suppression of neoclassical tearing modes. (unt.edu)
  • For the first time, experiments on the DIII-D tokamak have demonstrated electron cyclotron current drive (ECCD) with more than double the efficiency of the conventional outside launch by using a novel top launch geometry, as predicted by linear ray tracing and quasi-linear Fokker-Planck simulations. (uci.edu)
  • We have analyzed the effects of rapid thermal annealing on the composition and on the bonding and optical properties of amorphous hydrogenated silicon nitride (a-Si-x:H) thin films deposited at room temperature by the electron cyclotron resonance plasma method. (ucm.es)
  • We have obtained Al/SiNx:H/InP metal-insulator-semiconductor devices depositing SiNx:H thin films by the electron cyclotron resonance plasma method at 200 degrees C. The electrical properties of the structures were analyzed according to capacitance-voltage and deep level transient spectroscopy measurements. (ucm.es)
  • Lee, Jaejin 2018-01-01 00:00:00 It is well known that electromagnetic ion cyclotron (EMIC) waves play an important role in controlling particle dynamics inside the Earth's magnetosphere, especially in the outer radiation belt. (deepdyve.com)
  • It is well known that electromagnetic ion cyclotron (EMIC) waves play an important role in controlling particle dynamics inside the Earth's magnetosphere, especially in the outer radiation belt. (deepdyve.com)
  • Electromagnetic ion cyclotron (EMIC) waves and their role in governing proton populations in the ring current and radiation belt regions are of importance in understanding the dynamics of the Earth's magnetosphere. (auburn.edu)
  • The availability of SCATHA magnetic field and proton spectra data allowed us to study the electromagnetic proton cyclotron instability as a generation mechanism for EMIC waves and the relationship between EMIC waves and protons in the equatorial region of the magnetosphere. (auburn.edu)
  • First, we studied the conditions under which the electromagnetic proton cyclotron instability acts as a generation mechanism for EMIC waves in the Earth's magnetosphere. (auburn.edu)
  • Especially, the results show an inverse correlation between proton temperature anisotropy and proton parallel beta, that the observed proton temperature anisotropies are above the electromagnetic proton cyclotron instability thresholds, and that the observed waves actually get energy from energetic and anisotropic proton populations. (auburn.edu)
  • First measurements were performed to test a model prediction which states that the off-axis coupling of ion-cyclotron waves to energetic helium ions can generate either an inward or an outward drift of these particles. (differ.nl)
  • Ion-cyclotron waves with a power or up to 1 MW are coupled to energetic particles at the high field side, the low field side, or in the center by varying the toroidal magnetic field. (differ.nl)
  • A cyclotron is a type of particle accelerator invented by Ernest O. Lawrence in 1929-1930 at the University of California, Berkeley, and patented in 1932. (wikipedia.org)
  • Cyclotrons were the most powerful particle accelerator technology until the 1950s when they were superseded by the synchrotron, and are still used to produce particle beams in physics and nuclear medicine. (wikipedia.org)
  • A cyclotron is a type of particle accelerator. (wikipedia.org)
  • Cyclotron (comics), a minor character in the DC Universe Cyclotron (album), a 1993 album by the rock band Blind Idiot God the Louvain-la-Neuve Cyclotron, a particle accelerator and building of the University of Louvain (UCLouvain) in Belgium This disambiguation page lists articles associated with the title Cyclotron. (wikipedia.org)
  • 317-458) This invention relates to charge particle accelerators and more particularly to magnetic pole pieces for cyclotrons and like accelerators which poles will maintain a desired radial field gradient at any of various field intensities. (google.com)
  • The cyclotron was the first of the cyclical particle accelerators and it provided a much more efficient way to accelerate particles for further study. (thoughtco.com)
  • Hello, I'm always seeing the energy of a particle being accelerated in a cyclotron expressed in MeV or GeV. (physicsforums.com)
  • Id base the calculation on mass, charge (e) Voltage and Magnetic field strength (T). the cyclotron is imparting momentum to a massed particle with charge q. accel is based on q while energy and velocity are related to both mass and acceleration due to the electrostatic forces. (physicsforums.com)
  • Medical Cyclotron is a cyclotron that is a type of compact particle accelerator used to produce quantities of radioactive isotopes called positron emitters. (reportsnreports.com)
  • A cyclotron is a type of particle accelerator, and this one, a Cyclone-18, was purchased in 2012 and installed in 2014 at the former Yerevan Physics Institute. (nd.edu)
  • Rolf Widerøe , Gustav Ising , Leó Szilárd , Max Steenbeck , and Ernest Lawrence are considered pioneers of this field, conceiving and building the first operational linear particle accelerator , [4] the betatron , and the cyclotron . (wikipedia.org)
  • The largest cyclotrons are the TRIUMF 500 MeV Cyclotron , which is still in operation at the University of British Columbia in Vancouver, British Columbia, Canada, and the Superconducting Ring Cyclotron at Riken laboratory in Japan. (thoughtco.com)
  • The modern cyclotron uses two hollow D-shaped electrodes held in a vacuum between poles of an electromagnet. (encyclopedia.com)
  • A modern cyclotron used in medical therapy. (thoughtco.com)
  • Cyclotrons are also used for research purposes in academic and industrial settings, and for positron emission tomography (PET). (encyclopedia.com)
  • Jones Day represented a general medical and surgical hospital in connection with its acquisition of certain assets related to a positron emission tomography center and cyclotron. (jonesday.com)
  • Aga Khan University Hospital (AKUH) in Nairobi has acquired an ultra-modern Positron Emission Tomography (PET) CT scanner and Cyclotron from GE Healthcare. (hhmglobal.com)
  • The magnets cause electron-cyclotron resonance for the electrons of the plasma thus creating conditions for efficient absorption of the microwave energy. (google.com)
  • Plasmas created by microwave absorption at the electron cyclotron resonance (ECR) are increasingly used for a variety of plasma processes, including both etching and deposition. (harvard.edu)
  • In view of its high single pass absorption, hydrogen minority fundamental cyclotron heating in a deuterium plasma was chosen as the reference wave heating scheme in the ion cyclotron domain of frequencies. (ugent.be)
  • Ion cyclotron resonance heating (ICRH) experiments have been carried out in JET D-T plasmas using scenarios applicable to reactors. (epfl.ch)
  • The effect of ion cyclotron resonance heating (ICRH) on ((3)He)D plasmas at JET was studied with the time of flight optimized rate (TOFOR) spectrometer dedicated to 2.5 MeV dd neutron measurements. (diva-portal.org)
  • The largest single-magnet cyclotron was the 4.67 m (184 in) synchrocyclotron built between 1940 and 1946 by Lawrence at the University of California, Berkeley, which could accelerate protons to 730 mega electron volts (MeV). (wikipedia.org)
  • The largest cyclotron is the 17.1 m (56 ft) multimagnet TRIUMF accelerator at the University of British Columbia in Vancouver, British Columbia, which can produce 520 MeV protons. (wikipedia.org)
  • Ebco Technologies Inc. builds two different types of negative ion cyclotrons, one capable of accelerating protons to a maximum energy level of 19 MeV (TR19) and the other capable of accelerating protons to 32 MeV (TR32). (encyclopedia.com)
  • In collaboration with the Institute of Nuclear Physics it is additionally possible to irradiate solid targets with protons (45 MeV) and deuterons (78 MeV) from the injector cyclotron (JULIC) of the COSY storage ring. (fz-juelich.de)
  • The Asia Pacific held the largest share in the global medical cyclotron products market, its revenue of global market exceeds 31% in 2016. (reportsnreports.com)
  • Weitekamp and Wang join previous Cyclotron Road 30 Under 30 honorees Marcus Lehmann and Colin Bailie, who were part of the list in 2016. (cyclotronroad.org)
  • Lawrence received the 1939 Nobel Prize in Physics for the invention and development of the cyclotron and for results obtained with it. (wikipedia.org)
  • The first European cyclotron was constructed in Leningrad (then Soviet Union) in the physics department of the Radium Institute, headed by Vitaly Khlopin [ru]. (wikipedia.org)
  • Cyclotron may also refer to: Cyclotron resonance, a phenomenon observed both in plasma physics and condensed matter physics. (wikipedia.org)
  • Cyclotrons have been used in high-energy physics experiments for decades, and are also useful in medical treatments for cancer and other conditions. (thoughtco.com)
  • Following a staff vote, the cyclotron has been named Lise, honouring Lise Meitner's pioneering work in radioactivity and nuclear physics, including her role in the discovery of nuclear fission in the 1930s. (bouygues-uk.com)
  • Two years ago Aprahamian, the Freimann Professor of Physics at the University of Notre Dame, was vacationing with cousins when she decided to visit the National Laboratory of Armenia to check on the progress of a newly purchased cyclotron. (nd.edu)
  • These new diagnostic capabilities are applied to study the physics of 2nd harmonic ion cyclotron heating, which is a foreseen heating scenario for ITER. (dtu.dk)
  • Dissipation is produced by an instability associated with electron cyclotron oscillations. (springer.com)
  • We feature the largest catalog of tracers in Canada , that are all produced onsite in our research-dedicated cyclotron and radiochemistry laboratory. (mcgill.ca)
  • VENUS ( V ersatile E CR ion source for NU clear S cience) is a next generation superconducting ECR ion source, designed to produce high current, high charge state ions for the 88-Inch Cyclotron at the Lawrence Berkeley National Laboratory. (lbl.gov)
  • The design and fabrication of the magnet structure is based on a collaborative effort between the 88-Inch Cyclotron of the Nuclear Science Division and the Supercon Group in the Accelerator and Fusion Research Division at Lawrence Berkeley National Laboratory. (lbl.gov)
  • The preparation and radiochemical isolation of a number of these activities, produced in the 60-inch cyclotron of Crocker Laboratory, will be presented in this paper and in subsequent papers of this series. (unt.edu)
  • Using statistical wave power spectral profiles obtained from CRRES and the latitudinal distributions of wave propagation modeled by the HOTRAY code, a quantitative analysis has been performed on the scattering of plasma sheet electrons into the diffuse auroral zone by multiband electrostatic electron cyclotron harmonic (ECH) emissions near L = 6 within the 0000-0600 MLT sector. (nerc.ac.uk)
  • Its cyclotrons are used for the commercial production and distribution of PET and SPECT nuclides by internationally recognized companies and leading research facilities. (advancedcyclotron.com)
  • The 25P cyclotron is a mid range cyclotron that is capable of producing commercial quantities of both PET and SPECT radio-compounds. (isosolutions.com)
  • This publication contains radioisotope decay and production details of 49 isotopes that can be prepared using cyclotrons. (iaea.org)
  • The introductory chapter discusses the principles of radioisotope production using cyclotrons, and the publication contains data on nuclear decay characteristics such as half-life, mode of decay, energy and abundance, nuclear reactions and excitation functions of the selected isotopes. (iaea.org)
  • One major way the cyclotron will play such a big role in transforming UAB and Birmingham is by producing these tiny - yet key - molecules called isotopes that can be used to more effectively discover cancer and other diseases in the body and help doctors figure out how to treat those diseases. (bizjournals.com)
  • Isotopes produced by the cyclotron are used to create the molecules needed in the treatment of cancer and other diseases. (bizjournals.com)
  • All isotopes for the Life Sciences program are produced on TRIUMF's TR13 cyclotron [ 2 , 3 ], a self-shielded 13 MeV negative ion accelerator, which is capable of extracting two proton beams of up to 50 µA simultaneously. (mdpi.com)
  • Recently, TBG has developed a 35 MeV Alpha, Deuteron and Proton Cyclotron for production of medical isotopes and other applications. (einpresswire.com)
  • It still accomplishes an important role as a novel cyclotron system for production of large quantities of medical isotopes and generation of deuteron and alpha particles. (einpresswire.com)
  • The small, approximately 6-foot long cyclotron at Yerevan was intended to provide short-lived radioactive isotopes that can be used for positron-electron tomography ( PET ) scans that diagnose and detect cancerous tumors. (nd.edu)
  • This one cyclotron will produce enough medical isotopes to meet all the needs of patients in Armenia as well as surrounding countries, according to Aprahamian. (nd.edu)
  • It is therefore an object of the invention to provide a pole construction for producing a magnetic field of the desired configuration in a variable energy cyclotron. (google.com)
  • 2. The cyclotron of claim 1 , wherein the magnet yoke is dimensioned such that the vacuum pump does not experience magnetic fields in excess of 75 Gauss when an average magnetic field between the pole tops is 1.0 Tesla. (google.es)
  • 10. The cyclotron of claim 1 , wherein the vacuum pump is at a pump location and wherein the pump location does not experience magnetic fields in excess of 75 Gauss when the pump location is not magnetically shielded by a magnetic shield. (google.es)
  • These simulations allow us to check on the diffusion of poloidal magnetic flux, as well as the modelling of the electron cyclotron heating. (epfl.ch)
  • The magnetic field generated by the magnetic coils forces ions to follow a cyclotron trajectory around the magnetic field lines due to the Lorentz force. (upc.edu)
  • Continuing the experiments done last year, we have performed the magnetic resonance and cyclotron resonance on some rare-earth compounds using vector network analyzer system developed recently at ultra low temperatures and high magnetic fields. (nii.ac.jp)
  • In particular, we investigate filling factor dependent splittings of the cyclotron resonance in strong magnetic fields and a crossing of Landau levels of the conduction and valence subband. (uni-regensburg.de)
  • The target changer allows the cyclotron operator to select different targets on each of the beamlines to be irradiated and are made primarily from aluminum, with a minimum of stainless-steel to minimize neutron activation. (encyclopedia.com)
  • The present work describes an experimental system enabling temperature measurement in cyclotron targets' cooling water during bombardment. (mdpi.com)
  • The B35adp accesses the family of production targets that TeamBest Global offers for the B35 cyclotron. (einpresswire.com)
  • This paper briefly reviews the cyclotron technique of 89 Zr production and outlines the range and preparation techniques available for making 89 Y targets as a starting material. (snmjournals.org)
  • To get your PET study started and all other related inquiries, please contact the PET Medical Director (protocol) or the Director of Cyclotron (production of existing and new tracers). (mcgill.ca)
  • Please contact the Gassan.Massarweh [at] mcgill.ca (subject: Production%20of%20PET%20Tracers) (Director of Cyclotron) to inquire about the production of other tracers not featured in the list. (mcgill.ca)
  • The PETtrace tracer production system is a compact, automated cyclotron designed for the fast, easy and efficient production of PET radiotracers. (dotmed.com)
  • Cyclotron production of 99m Tc: experimental measurement of the 100 Mo(p,x) 99 Mo, 99m Tc and 99g Tc excitation functions from 8 to 18 MeV," Nuclear Medicine and Biology , vol. 38, no. 6, pp. 907-916, 2011. (hindawi.com)
  • Analyzes the physical limitations of the highly charged ion production in the electron cyclotron resonance (ECR) ion source. (ebscohost.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of Medical Cyclotron industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (researchmoz.us)
  • TeamBest Global (TBG) Companies and Best Cure Foundation (BCF) are planning to establish hundreds of cyclotrons and other systems worldwide for Radioisotope Production, Research, Green Energy, etc., and operate them for more efficient Medical Diagnosis/Treatment/Research and Green Energy Developments. (einpresswire.com)
  • Given the high degree of integration between the cyclotron and radioisotope production systems, customization of hotcells, target and radioisotope delivery systems, and radiopharmacy equipment to the specific radiopharmaceutical production processes is required. (advancedcyclotron.com)
  • Small cyclotrons that produce FDG are designed to take advantage of production reactions that are optimum at low cyclotron energies. (isosolutions.com)
  • The accelerating chamber of the first cyclotron measured 5 in (12.7 cm) in diameter and boosted hydrogen ions to energy of 5-45 MeV depending on the settings. (encyclopedia.com)
  • A cyclotron that includes a magnet yoke having a yoke body that surrounds an acceleration chamber. (google.es)
  • 4. The cyclotron of claim 1 , wherein the yoke body forms a pump-acceptance (PA) cavity within the envelope that is fluidicly coupled to the acceleration chamber, the vacuum pump being positioned in the PA cavity. (google.es)
  • A group of almost 30 scientists and engineers from six research institutions reported the direct detection of cyclotron radiation from individual electrons April 20 in Physical Review Letters . (eurekalert.org)
  • About five years ago, two of the co-authors on this study proposed that perhaps instead of detecting neutrinos, or even electrons directly, they could come at the problem sideways by measuring electrons' cyclotron radiation, which can reveal an electron's energy. (eurekalert.org)
  • He also invented and patented the first cyclotron and betatron too. (wikipedia.org)
  • Gathering a few dozen collaborators into Project 8, the team developed a new method called Cyclotron Radiation Emission Spectroscopy to do so, and demonstrated it in this study. (eurekalert.org)
  • Latest results of pulse phase resolved spectroscopy of cyclotron lines in accretion powered pulsars. (ebscohost.com)
  • We have performed pulse phase resolved spectroscopy of the Cyclotron Resonance Scattering Features (CRSF) of some bright accretion powered X-ray pulsars like 1A 1118-61, Vela X-1, A0535+26, XTE J1946+274, 4U 1907+09, 4U 1626-67 and GX 301-2 using Suzaku observations with long exposures. (ebscohost.com)
  • https://www.thoughtco.com/what-is-a-cyclotron-2699099 (accessed March 23, 2018). (thoughtco.com)
  • Following the 2018 revolution in Armenia known as the Velvet Revolution, the new government will decide the role the cyclotron will play. (nd.edu)
  • Varian announced the installation of the cyclotron for its ProBeam® proton therapy system at the National Taiwan University Cancer Center (NTUCC). (varian.com)
  • The cyclotron is a core piece of equipment of the system and its installation marks a key milestone for NTUCC, as the first cancer center in Taiwan with a ProBeam system. (varian.com)
  • Ltd, the completion of the cyclotron installation for the Varian ProBeam® Compact single-room proton therapy system at Biopolis, an international biomedical research hub. (thomasnet.com)
  • The cyclotron is a core piece of equipment in the ProBeam proton therapy system. (thomasnet.com)
  • Unlike other compact systems available today, the cyclotron in the Varian ProBeam Compact system is the same high-power unit used in centers conducting pioneering research into Flash therapy. (thomasnet.com)
  • We are proud of our collaboration with Proton Therapy Pte for the installation of the ProBeam Compact proton system cyclotron at this new center," said Kolleen Kennedy, president, Proton Solutions and chief growth officer, Varian. (thomasnet.com)
  • [2] The Centre houses a 224 cm cyclotron -the first of its kind in India-which has been operational since 16 June 1977. (wikipedia.org)
  • The PET Cyclotron is currently operational. (albertahealthservices.ca)
  • When Aprahamian visited, she was shocked to discover that the cyclotron still was not operational. (nd.edu)
  • Experiments on a 14.5 GHz electron cyclotron resonance source. (ebscohost.com)
  • A new solid target system for the TRIUMF TR13 cyclotron that can accommodate target discs with a 1-2-mm thickness and a 28-mm diameter has been developed. (mdpi.com)
  • To go in search of true discovery with PET, access to a cyclotron is necessary, and yet they are considered the most difficult and sophisticated part of a PET installation. (gehealthcare.com)
  • The self-shielded feature eliminates the need for a cyclotron vault or major upgrades to existing facilities. (encyclopedia.com)
  • Combined with our 7-T small-bore MRI scanner, our on-site cyclotron, radiochemistry, and HPLC facilities, we offer the best service to develop functional and molecular imaging of disease models. (mcgill.ca)
  • Such a system finds application either as a monitoring safety device to instantaneously detect and register abnormal alterations in target conditions to anticipate thermal-related incidents and as a tool to experimentally validate cyclotron targetry optimization studies and thermal simulations. (mdpi.com)
  • Our team of professionals will work closely with you and your colleagues to prepare and review your TR cyclotron system requirements. (advancedcyclotron.com)
  • This service is included in your cyclotron system purchase. (advancedcyclotron.com)
  • 2014. "Hydrogen Minority Ion Cyclotron Resonance Heating in Presence of the Iter-like Wall in Jet. (ugent.be)
  • ACSI is excited to showcase its wide range of cyclotron products and services to the meeting's attendees in Vienna, Austria. (advancedcyclotron.com)
  • ACSI provides customized cyclotrons solutions for research institutes, hospitals, and commercial radionuclide producers from its extensive cyclotron lineup. (advancedcyclotron.com)
  • ACSI cyclotrons are designed, manufactured and assembled in Richmond, Canada. (advancedcyclotron.com)
  • NEW DELHI, DELHI, INDIA, June 16, 2021 / EINPresswire.com / -- Over the last several years, Best Cyclotron Systems and Best ABT Molecular Imaging of the TeamBest Global Group of Companies (TBG), have developed a series of cyclotrons for medical, industrial and research applications. (einpresswire.com)
  • A couple months later, in the early summer of 1929, Ernest Lawrence came up with the cyclotron idea when he read a paper by Rolf Widerøe describing a drift tube linac. (wikipedia.org)
  • E. O. Lawrence and his graduate students at the University of California, Berkley tried many different configurations of the cyclotron before they met with success in 1929. (encyclopedia.com)
  • The present state of the polarized proton and deuteron source at the Bonn cyclotron is described. (osti.gov)
  • The Variable Energy Cyclotron Centre ( VECC ) is a research and development unit of the Department of Atomic Energy . (wikipedia.org)
  • RADIAL POSITION 4 INVENTORS RICHARD J. BURLE/GH ELMER L. KELLY BY JOSEPH H. DORST CHARLES G. DOLS ATTORNEY United States Patent 0 MAGNET CQNSTRUCTEON FOR A VARIABLE ENERGY CYCLOTRON Richard J. Burleigh, Elmer L. Kelly, Joseph H. Durst, and Qharles G. Dole, all of Berkeley, Calif., assignors to the United States of America as represented by the United States Atomic Energy Commission Filed Feb. 8, 1961, Ser. (google.com)
  • Cheri Cannon , chairwoman of UAB's Department of Radiology, said the cyclotron has prompted the university to bring in an engineer to operate the tool, a radio pharmacists and two radio chemists. (bizjournals.com)
  • Proton beams from all cyclotrons have a maximum theoretical energy that is called their K-number. (msu.edu)
  • The first machine at MSU was the K50 cyclotron that could produce 50 MeV (million electron volts of energy) beams. (msu.edu)
  • The name of the A1900 indicates that it is more powerful at bending and separating out reaction products than the cyclotron that produces the primary beams. (msu.edu)
  • Physically, the cyclotron weighs 55 tons, and is located inside an inner vault with concrete walls and doors about 6.6 ft (2 m) thick to shield the surroundings from the nuclear radiation present when the machine runs. (encyclopedia.com)
  • After reaching the critical radius the accelerated particles are extracted from the cyclotron and directed onto a target to induce the desired nuclear reaction. (fz-juelich.de)
  • The AHS Class II license for the PET Cyclotron operates under an operating license issued by the Canadian Nuclear Safety Commission. (albertahealthservices.ca)
  • Cyclotrons are a clean nuclear technology and create very little radioactive waste as a result of their operation. (reportsnreports.com)
  • The start of the cyclotron center of nuclear medicine can change the situation," added Rector Koksharov. (indiaeducationdiary.in)