Cyclotides
Viola
Oldenlandia
Cystine Knot Motifs
Panicum
Clitoria
Trichostrongylosis
Solanaceae
Trichostrongylus
Plant Proteins
Peptides, Cyclic
Chromatography, Affinity
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Acid Sensing Ion Channel Blockers
Cyclization
Expressed Sequence Tags
Rubiaceae
Ipecac
A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha and C. acuminata. They contain EMETINE, cephaeline, psychotrine and other ISOQUINOLINES. Ipecac syrup is used widely as an emetic acting both locally on the gastric mucosa and centrally on the chemoreceptor trigger zone.
Receptors, Corticotropin-Releasing Hormone
Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.
Models, Molecular
Uterus
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
Asia, Western
Love
Encyclopedias as Topic
Medicine in Literature
Rutin
Amaranthus
Drama
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Structure-Activity Relationship
Molecular Structure
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. (1/74)
Four macrocyclic cystine-knot peptides of 29-31 residues, kalata, circulin A and B (CirA and CirB), and cyclopsychotride, have been isolated from coffee plants but have undetermined physiological functions. These macrocycles and 10 of their analogs prepared by chemical synthesis were tested against nine strains of microbes. Kalata and CirA were specific for the Gram-positive Staphylococcus aureus with a minimum inhibition concentration of approximately 0.2 microM. They were relatively ineffective against Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. However, CirB and cyclopsychotride were active against both Gram-positive and Gram-negative bacteria. In particular, CirB showed potent activity against E. coli with a minimum inhibitory concentration of 0.41 microM. All four cyclic peptides were moderately active against two strains of fungi, Candida kefyr and Candida tropicalis, but were inactive against Candida albicans. These macrocycles are cytotoxic and lysed human red blood cell with a lethal dose 50% of 400 microM. Modifying the Arg residue in kalata with a keto aldehyde significantly reduced its activity against S. aureus whereas blocking the arg in CirA produced no significant effect. The two-disulfide variants and their scrambled disulfide isomers exhibited antimicrobial profiles and potency similar to their native peptides. However, in high-salt assays (100 mM NaCl), few of these macrocyclic peptides, natives or analogs, retained antimicrobial activity. These results show that the macrocyclic peptides possess specific and potent antimicrobial activity that is salt-dependent and that their initial interactions with the microbial surfaces may be electrostatic, an effect commonly found in defensin antimicrobial peptides. Furthermore, their end-to-end cyclic structure with a cystine-knot motif represents a molecular structure of antimicrobials and may provide a useful template for the design of novel peptide antibiotics. (+info)Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1. (2/74)
Kalata B1 is a prototypic member of the unique cyclotide family of macrocyclic polypeptides in which the major structural features are a circular peptide backbone, a triple-stranded beta-sheet, and a cystine knot arrangement of three disulfide bonds. The cyclotides are the only naturally occurring family of circular proteins and have prompted us to explore the concept of acyclic permutation, i.e. opening the backbone of a cross-linked circular protein in topologically permuted ways. We have synthesized the complete suite of acyclic permutants of kalata B1 and examined the effect of acyclic permutation on structure and activity. Only two of six topologically distinct backbone loops are critical for folding into the native conformation, and these involve disruption of the embedded ring in the cystine knot. Surprisingly, it is possible to disrupt regions of the beta-sheet and still allow folding into native-like structure, provided the cystine knot is intact. Kalata B1 has mild hemolytic activity, but despite the overall structure of the native peptide being retained in all but two cases, none of the acyclic permutants displayed hemolytic activity. This loss of activity is not localized to one particular region and suggests that cyclization is critical for hemolytic activity. (+info)Cyclotides: a novel type of cytotoxic agents. (3/74)
Cytotoxic activities of three naturally occurring macrocyclic peptides (cyclotides) isolated from the two violets, Viola arvensis Murr. and Viola odorata L., were investigated. A nonclonogenic fluorometric microculture assay was used to examine cytotoxicity in a panel of 10 human tumor cell lines representing defined types of cytotoxic drug resistance. Additionally, primary cultures of tumor cells from patients, and for comparison normal lymphocytes, were used to quantify cytotoxic activity. All three cyclotides, varv A, varv F, and cycloviolacin 02, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. Cycloviolacin 02 was the most potent in all cell lines (IC50 0.1-0.3 microM), followed by varv A (IC50 2.7-6.35 microM) and varv F (IC50 2.6-7.4 microM), respectively. Activity profiles of the cyclotides differed significantly from those of antitumor drugs in clinical use, which may indicate a new mode of action. This, together with the exceptional chemical and biological stability of cyclotides, makes them interesting in particular for their potential as pharmacological tools and possibly as leads to antitumor agents. (+info)Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. (4/74)
The plant cyclotides are a fascinating family of circular proteins that contain a cyclic cystine knot motif. The knotted topology and cyclic nature of the cyclotides pose interesting questions about folding mechanisms and how the knotted arrangement of disulfide bonds is formed. In the current study we have examined the oxidative refolding and reductive unfolding of the prototypic cyclotide, kalata B1. A stable two-disulfide intermediate accumulated during oxidative refolding but not in reductive unfolding. Mass spectrometry and NMR spectroscopy were used to show that the intermediate contained a native-like structure with two native disulfide bonds topologically similar to the intermediate isolated for the related cystine knot protein EETI-II (Le-Nguyen, D., Heitz, A., Chiche, L., El Hajji, M., and Castro B. (1993) Protein Sci. 2, 165-174). However, the folding intermediate observed for kalata B1 is not the immediate precursor of the three-disulfide native peptide and does not accumulate in the reductive unfolding process, in contrast to the intermediate observed for EETI-II. These alternative pathways of linear and cyclic cystine knot proteins appear to be related to the constraints imposed by the cyclic backbone of kalata B1 and the different ring size of the cystine knot. The three-dimensional structure of a synthetic version of the two-disulfide intermediate of kalata B1 in which Ala residues replace the reduced Cys residues provides a structural insight into why the two-disulfide intermediate is a kinetic trap on the folding pathway. (+info)The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis. (5/74)
The disulfide structure of the CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto protein was determined by a combination of enzymatic and chemical fragmentation, followed by chromatographic separation of the fragments, and characterization by mass spectrometry and N-terminal sequencing. These studies showed that Cys115 forms a disulfide bond with Cys133, Cys128 with Cys149, and Cys131 with Cys140. Protein database searching and molecular modeling revealed that the pattern of disulfide linkages in the CFC domain of Cripto is the same as that in PARS intercerebralis major Peptide C (PMP-C), a serine protease inhibitor, and that the EGF-CFC domains of Cripto are predicted to be structurally homologous to the EGF-VWFC domains of the C-terminal extracellular portions of Jagged 1 and Jagged 2. Biochemical studies of the interactions of ALK4 with the CFC domain of Cripto by fluorescence-activated cell sorter analysis indicate that the CFC domain binds to ALK4 independent of the EGF domain. A molecular model of the CFC domain of Cripto was constructed based on the nuclear magnetic resonance structure of PMP-C. This model reveals a hydrophobic patch in the domain opposite to the presumed ALK4 binding site. This hydrophobic patch may be functionally important for the formation of intra or intermolecular complexes. (+info)Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. (6/74)
The cyclotides are a recently discovered family of plant proteins that have the fascinating structural feature of a continuous cyclic backbone and, putatively, a knotted arrangement of their three conserved disulfide bonds. We here show definite chemical proof of the I-IV, II-V, III-VI knotted disulfide connectivity of the prototypic cyclotide kalata B1. This has been achieved by a new approach for disulfide analysis, involving partial reduction and stepwise alkylation including introduction of charges and enzymatic cleavage sites by aminoethylation of cysteines. The approach overcomes the intrinsic difficulties for disulfide mapping of cyclotides, i.e. the cyclic amide backbone, lack of cleavage sites between cysteines, and a low or clustered content of basic amino acids, and allowed a direct determination of the disulfide bonds in kalata B1 using analysis by mass spectrometry. The established disulfide connectivity is unequivocally shown to be cystine knotted by a topological analysis. This is the first direct chemical determination of disulfides in native cyclotides and unambiguously confirms the unique cyclic cystine knot motif. (+info)A comparison of the self-association behavior of the plant cyclotides kalata B1 and kalata B2 via analytical ultracentrifugation. (7/74)
The recently discovered cyclotides kalata B1 and kalata B2 are miniproteins containing a head-to-tail cyclized backbone and a cystine knot motif, in which disulfide bonds and the connecting backbone segments form a ring that is penetrated by the third disulfide bond. This arrangement renders the cyclotides extremely stable against thermal and enzymatic decay, making them a possible template onto which functionalities can be grafted. We have compared the hydrodynamic properties of two prototypic cyclotides, kalata B1 and kalata B2, using analytical ultracentrifugation techniques. Direct evidence for oligomerization of kalata B2 was shown by sedimentation velocity experiments in which a method for determining size distribution of polydisperse molecules in solution was employed. The shape of the oligomers appears to be spherical. Both sedimentation velocity and equilibrium experiments indicate that in phosphate buffer kalata B1 exists mainly as a monomer, even at millimolar concentrations. In contrast, at 1.6 mm, kalata B2 exists as an equilibrium mixture of monomer (30%), tetramer (42%), octamer (25%), and possibly a small proportion of higher oligomers. The results from the sedimentation equilibrium experiments show that this self-association is concentration dependent and reversible. We link our findings to the three-dimensional structures of both cyclotides, and propose two putative interaction interfaces on opposite sides of the kalata B2 molecule, one involving a hydrophobic interaction with the Phe6, and the second involving a charge-charge interaction with the Asp25 residue. An understanding of the factors affecting solution aggregation is of vital importance for future pharmaceutical application of these molecules. (+info)Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework. (8/74)
The cyclotides are a family of disulfide-rich proteins from plants. They have the characteristic structural features of a circular protein backbone and a knotted arrangement of disulfide bonds. Structural and biochemical studies of the cyclotides suggest that their unique physiological stability can be loaned to bioactive peptide fragments for pharmaceutical and agricultural development. In particular, the cyclotides incorporate a number of solvent-exposed loops that are potentially suitable for epitope grafting applications. Here, we determine the structure of the largest known cyclotide, palicourein, which has an atypical size and composition within one of the surface-exposed loops. The structural data show that an increase in size of a palicourein loop does not perturb the core fold, to which the thermodynamic and chemical stability has been attributed. The cyclotide core fold, thus, can in principle be used as a framework for the development of useful pharmaceutical and agricultural bioactivities. (+info)
Single-step purification of cyclotides using affinity chromatography
Cyclotides evolve : Studies on their natural distribution, structural diversity, and activity
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
Frontiers | Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor |...
Cybase
Cybase
Cybase
Cybase
Discovery of Cyclotide-Like Protein Sequences in Graminaceous Crop Plants: Ancestral Precursors of Circular Proteins? | Plant...
Protein structure in drug and insecticide design - Institute for Molecular Bioscience - University of Queensland
Structural and functional characterization of chimeric cyclotides from the Mobius and trypsin inhibitor subfamilies, - ARC...
SNAr-Based Cycloetherification Methodology: Application in the Synthesis of Heterodectic Macrocyclic Peptides with Endo Aryl...
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Analysis of cyclotides in Viola ignobilis by Nano liquid chromatography fourier transform mass spectrometry - ResearchOnline...
Molecular Cloning and Characterization of a Cyclotide Gene Family in Viola modesta Fenzl
Anticancer activities of Oldenlandia diffusa.
Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia...
Research Progress of Pharmacological Functions of Oldenlandia diffusa--《Journal of Anhui Agricultural Sciences》2007年20期
Crystallization and Structure of a Plant Peptide Deformylase by Robert L. Houtz, David W. Rodgers et al.
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Rumput Mutiara/Oldenlandia (Hedyotis corymbosa) | CCRC
Apoptosis Induced by Viola odorata Extract in Human Glioblastoma Multiforme | Archives of Neuroscience | Full Text
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Violaceae
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Insecticidal compounds in plants
Fresh Water Pearl Expandable Bangle Gemstone Bracelet in Silver. BellaRyann.com
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Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. - PubMed - NCBI
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Inhibitor cystine knot
The motif is similar to the cyclic cystine knot or cyclotide, but lacks the cyclisation of the polypeptide backbone which is ... "Knots". Cyclotide.com. Archived from the original on 2015-02-05. Retrieved 2018-03-13. Reinwarth, Molecules 17:12533 2012 http ... cyclotide). Types include a) cyclic mobius, b) cyclic bracelet, c) acyclic inhibitor knottins. Cystine knot motifs are found ...
Asparagine endopeptidase
Craik DJ (February 2012). "Host-defense activities of cyclotides". Toxins. 4 (2): 139-56. doi:10.3390/toxins4020139. PMC ...
List of plants used in herbalism
Svangård E, Göransson U, Hocaoglu Z, Gullbo J, Larsson R, Claeson P, Bohlin L (February 2004). "Cytotoxic cyclotides from Viola ... August 2010). "Isolation and characterization of cytotoxic cyclotides from Viola tricolor". Peptides. 31 (8): 1434-40. doi: ...
Cystine knot
"Cystine Knots". The Cyclotide Webpage. Sherbet, G.V. (2011), "Growth Factor Families", Growth Factors and Their Receptors in ... Craik DJ, Daly NL, Bond T, Waine C (December 1999). "Plant cyclotides: A unique family of cyclic and knotted proteins that ... The presence of the cyclic cystine knot (CCK) motif was discovered when cyclotides were isolated from various plant families. ... or cyclotide The growth factor cystine knot was first observed in the structure of nerve growth factor (NGF), solved by X-ray ...
Viola tricolor
Many cyclotides, found in Viola tricolor are cytotoxic. This feature means it could be used to treat cancers. Extracts from the ... "Cytotoxic Cyclotides from Viola tricolor" Journal of Natural Products 67 (2), 144-147 Witkowska-Banaszczak E, Bylka W, ... tricolor is one of many viola plant species containing cyclotides. These small peptides have proven to be useful in drug ... "Isolation and characterization of cytotoxic cyclotides from Viola tricolor", Peptides 2010 31:8 (1434-1440) Erika Svangård, Ulf ...
Viola arvensis
2002). "Cyclotides: A Novel Type of Cytotoxic Agents" (PDF). Molecular Cancer Therapeutics. American Association for Cancer ... Viola arvensis was shown to contain cyclotides, a class of peptides found in plants. The peptide cycloviolacin O2 in particular ...
Cliotide
For example, cyclotides from aerial organs possess tighter binding activity to insect-like membranes, whereas cyclotides from ... The isolated Cter M cyclotide that is highly expressed in aerial organs was shown to effectively slow the growth and kill moth ... Different cyclotides have protein sequences which engender different biophysical and functional properties, to be expressed in ... Cliotides belong to a larger classification of peptides, the cyclotides. Preliminary studies show that cliotides display a ...
Viola tricolor
Many cyclotides, found in Viola tricolor are cytotoxic.[7] This feature means that it could be used to treat cancers.[8][7] ... V. tricolor is one of many viola plant species containing cyclotides. These small peptides have proven to be useful in drug ... "Cytotoxic Cyclotides from Viola tricolor" Journal of Natural Products 67 (2), 144-147 ... "Isolation and characterization of cytotoxic cyclotides from Viola tricolor", Peptides 2010 31:8 (1434-1440) ...
Cyclic peptide
"Application of a TLC chemical method to detection of cyclotides in plants". Science Bulletin. 53 (11): 1671-1674. doi:10.1007/ ...
Susan Wray
Her work has also investigated the use of plant-derived cyclotides as well as modifications to the natural hormone oxytocin to ... "Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design". Proceedings of the National ...
Viola abyssinica
Several unique cyclotides have been isolated from this species, that have cytotoxic properties and may be of use in the ... CS1 maint: discouraged parameter (link) Yeshak, M.Y.; Burman, R.; Asres, K.; Göransson, U. (2011). "Cyclotides from an extreme ...
Rinorea dentata
Researchers found that the plant contained novel cyclotides, but further research is needed on the efficacy of these extracts. ... used in South-Western Nigerian ethnomedicine and detection of cyclotides". Journal of Ethnopharmacology. 179: 183-191. doi: ...
Alanine scanning
Cyclotides display a wide range of pharmaceutically important bioactivities, but their natural function is in plant defense as ... On the structure of cyclotides kalata B1, all 23 non-cysteine residues were successively substituted with alanine. The data ... "Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity". J. Biol. ... of alanine scanning is to determine the influence of individual residues on structure and activity in the prototypic cyclotide ...
Clitoria ternatea
Jul 2011). "Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 ... a Cyclotide-Bearing Plant with Applications in Agriculture and Medicine". Frontiers in Plant Science. 10: 645. doi:10.3389/fpls ... chain a and cyclotide domains in the Fabaceae family" (PDF). J Biol Chem. 286 (27): 24275-87. doi:10.1074/jbc.m111.229922. PMC ...
Viola uliginosa
... for endangered species conservation and for somaclonal variation-enhanced cyclotide biosynthesis. Plant Cell Tiss Organ Cult ...
Hedyotis
Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP: Discovery of a linear cyclotide from the bracelet subfamily and its ... Both hedyotide B1 and B2 belong to the cyclotide superfamily which was known to be an important part of plant innate defense. ... Hedyotide B1 and cyclotides are likely to exerted their antimicrobial actions by disrupting the bacteria membranes which ... Optimal Oxidative Folding of the Novel Antimicrobial Cyclotide from Hedyotis biflora Requires High Alcohol Concentrations. ...
Rotaxane
... cyclotides or lasso-peptides such as microcin J25. The earliest reported synthesis of a rotaxane in 1967 relied on the ...
Möbius strip - Simple English Wikipedia, the free encyclopedia
The cyclotide (cyclic protein) Kalata B1, active substance of the plant Oldenlandia affinis, contains Möbius topology for the ...
Mechanically interlocked molecular architectures
... cyclotides or lasso-peptides such as microcin J25 which are protein, and a variety of peptides. Experimentally the first ...
List of MeSH codes (D12.644)
... cyclotides MeSH D12.644.641.252 - dactinomycin MeSH D12.644.641.270 - daptomycin MeSH D12.644.641.297 - depsipeptides MeSH ...
Möbius strip
Möbius aromaticity Charged particles caught in the magnetic field of the Earth that can move on a Möbius band The cyclotide ( ...
Cyclotide
The cyclotide domain may contain either one cyclotide sequence, as in the case of Oak1, or multiple copies separated by ... The cyclotides fall into two main structural subfamilies. Moebius cyclotides, the less common of the two, contain a cis-proline ... Cyclotides have also been identified in agriculturally important families such as the Fabaceae and Poaceae. Cyclotides have a ... The potent insecticidal activity of cyclotides kalata B1 and kalata B2 has prompted the belief that cyclotides act as plant ...
Publications | NCBS
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APD2: The updated antimicrobial peptide database and its application in peptide design<...
The second version of our database (APD2) allows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins ... The second version of our database (APD2) allows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins ... The second version of our database (APD2) allows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins ... The second version of our database (APD2) allows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins ...
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The role of plant antimicrobial peptides (AMPs) in response to biotic and abiotic environmental factors
| Biological...
Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense. Planta 244:1029-1040. ... Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption. Biochimica et Biophysica Acta ... Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes. Journal of Natural Products 70:643-647 ... Cyclotides as natural anti-HIV agents. Biopolymers 90:51-60. https://doi.org/10.1002/bip.20886 ...
Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells
Cyclotides: a novel type of cytotoxic agents.Mol Cancer Ther 2002; 6: 365-9. ... Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria ... Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human ...
Investigational IBD Therapy T20K Shows Promise in Preclinical Studies
T20K belongs to a family of natural peptides derived from plants called cyclotides. Researchers found that cyclotides are able ... "We feel encouraged that cyclotides seem to mitigate T-cell activity, which is very positive and of even greater importance for ... So, when we got the request of investigating the effect of cyclotides in IBD from a pharmaceutical company that saw great ... Tagged animal models, cyclotide, Cyxone, natural product, preclinical studies, T Cells, T20K. ...
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Peptides4
- Cyclotides are defense peptides produced by several plant families. (archive.org)
- To investigate the peptides' influence on aphid feeding behavior, we used 20% sucrose diets supplemented with cyclotides and measured the effects with electrical penetration graph (EPG) technique. (archive.org)
- We also applied anti-cyclotide antibodies and immunohistochemistry to track the peptides in the digestive systems of the aphids. (archive.org)
- T20K belongs to a family of natural peptides derived from plants called cyclotides. (ibdnewstoday.com)
Cycloviolacin2
- The cycloviolacin cyclotides: cyO13 (100 µM) and cyO19 (50 µM) most strongly impeded aphid ingestion activities when applied in sucrose diet. (archive.org)
- Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. (ac.ir)
Peptide1
- He also established human antibody phage display technology at Scotgen in the early 90's, and more recently started Cyclogenix Ltd in the UK to explore the utility of the plant cyclotide family of micro-proteins as a scaffold for drug discovery, with particular emphasis on oral and BBB delivery of peptide or protein drugs and exploring cyclotide utility in T-cell activation and multi-specific anti-cancer agents. (abilitabio.com)
Effects1
- Cyxone decided to investigate the therapy as a potential IBD treatment following preclinical studies that showed positive effects of T20K on multiple sclerosis (MS). Interest in the effects of cyclotides on IBD was piqued after it was discovered that T20K appears to accumulate in the intestine and spleen, organs involved in IBD. (ibdnewstoday.com)
Plant3
- Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis. (ncbs.res.in)
- We demonstrate that cyclotides may play an important role in plant-aphid interactions. (archive.org)
- Plant AHDPs with anticancer activity can be conveniently discussed with reference to two groups: cyclotides, which possess cyclic molecules stabilized by cysteine knot motifs, and other ADHPs that adopt extended and α-helical conformations. (lincoln.ac.uk)
Diet1
- Our study shows that cyclotides affect aphid probing and feeding behavior and limit their diet sap uptake. (archive.org)