AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
CycloserineAntitubercular AgentsCulture MediaCell WallMicrobial Sensitivity TestsAnti-Bacterial AgentsMycobacterium tuberculosisCoproporphyria, HereditaryCoproporphyrinsCoproporphyrinogen OxidasePorphyrias, HepaticPorphyriasPorphyrinsPorphyrinogensTuberculosisTuberculosis, PulmonaryTuberculosis, Multidrug-ResistantPregnancyWasting Syndrome
Cycloserine
Antibiotic substance produced by Streptomyces garyphalus.
Antitubercular Agents
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Cell Wall
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Mycobacterium tuberculosis
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Coproporphyria, Hereditary
An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.
Coproporphyrins
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
Coproporphyrinogen Oxidase
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Porphyrias, Hepatic
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Porphyrinogens
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.
Tuberculosis, Multidrug-Resistant
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Wasting Syndrome
A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.

D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. (1/293)

A hypofunction of the glutamatergic system and NMDA receptors in schizophrenia has been hypothesized. Therefore, stimulation of these receptors could be of benefit to patients with schizophrenia. D-cycloserine has been used for this purpose. This study reports the effects of 100 mg D-cycloserine, when added to typical antipsychotics in chronic schizophrenic patients exhibiting prominent negative symptoms, using a placebo-controlled, double-blind, parallel, design. D-cycloserine slightly worsened psychotic symptoms and general psychopathology as compared to placebo. D-cycloserine failed to change negative symptoms and had no effect on extrapyramidal symptoms. The exacerbation of schizophrenic symptoms may be explained by the antagonistic effects of this dose of D-cycloserine at the glycine recognition site of the NMDA receptor due to competition with the endogenous agonist glycine. Another explanation for the increase in psychopathology may be an interaction with the effects of antipsychotics on NMDA mediated neurotransmission. Thus, D-cycloserine in this study did not ameliorate schizophrenic symptoms. However, the fact that they actually worsened suggests that NMDA systems may be involved in the pathogenesis of schizophrenia. Further placebo-controlled studies with lower dosages of D-cycloserine, preferably in drug-free patients, are necessary to evaluate if D-cycloserine is of use for the treatment of patients with schizophrenia.  (+info)

N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities. (2/293)

We showed previously that the induction of neural crest (NC) and neural tube (NT) defects is a general property of N-methyl-D-aspartate receptor (NMDAR) antagonists. Since homocysteine induces NC and NT defects and can also act as an NMDAR antagonist, we hypothesized that the mechanism of homocysteine-induced developmental defects is mediated by competitive inhibition of the NMDAR by homocysteine. If this hypothesis is correct, homocysteine-induced defects will be reduced by NMDAR agonists. To test the hypothesis, we treated chicken embryos during the process of neural tube closure with sufficient homocysteine thiolactone to induce NC and NT defects in approximately 40% of survivors or with homocysteine thiolactone in combination with each of a selected set of NMDAR agonists in 0. 05-5000 nmol doses. Glutamate site agonists selected were L-glutamate and N-methyl-D-aspartate. Glycine site agonists were glycine, D-cycloserine, and aminocyclopropane-carboxylic acid. Glycine was the most effective overall, reducing defects significantly at two different doses (each P>0.001). These results support the hypothesis that homocysteine may affect NC and NT development by its ability to inhibit the NMDAR. One potentially important consequence of this putative mechanism is that homocysteine may interact synergistically with other NMDAR antagonists to enhance its effect on development.  (+info)

Flavone acetic acid induces a G2/M cell cycle arrest in mammary carcinoma cells. (3/293)

Flavone acetic acid (FAA) is a synthetic flavonoid that demonstrated extraordinary anti-tumour properties in murine models but was not effective in clinical trials. In an effort to better understand the molecular mechanisms by which FAA asserts its tumouricidal activities, we have examined the effect of FAA on the cell cycle. We observed FAA-mediated G2/M cell cycle arrest in mammary carcinoma cells at a concentration previously demonstrated to have anti-tumour effects in rodent models. The cell cycle arrest was accompanied by an increase in the P34cdc2 (cdc2) cyclin-dependent kinase activity. Morphological cytogenetic analysis demonstrated a colcemid-like effect of FAA on cytokinesis by causing accumulation of condensed C-metaphases of a sustained mitotic block. The cell cycle effect was blocked by the antioxidants ADPC and ascorbate, the superoxide scavenger Tiron, and the sphingosine kinase inhibitor L-cycloserine, but not by inhibitors of nitric oxide synthase. Based on these data, we propose that FAA may induce cell cycle arrest by stimulating the activity of acidic sphingomyelinase leading to the generation of reactive oxygen species.  (+info)

Induction of beta-lactamase influences the course of development in Myxococcus xanthus. (4/293)

Myxococcus xanthus is a gram-negative bacterium that develops in response to starvation on a solid surface. The cells assemble into multicellular aggregates in which they differentiate from rod-shaped cells into spherical, environmentally resistant spores. Previously, we have shown that the induction of beta-lactamase is associated with starvation-independent sporulation in liquid culture (K. A. O'Connor and D. R. Zusman, Mol. Microbiol. 24:839-850, 1997). In this paper, we show that the chromosomally encoded beta-lactamase of M. xanthus is autogenously induced during development. The specific activity of the enzyme begins to increase during aggregation, before spores are detectable. The addition of inducers of beta-lactamase in M. xanthus, such as ampicillin, D-cycloserine, and phosphomycin, accelerates the onset of aggregation and sporulation in developing populations of cells. In addition, the exogenous induction of beta-lactamase allows M. xanthus to fruit on media containing concentrations of nutrients that are normally too high to support development. We propose that the induction of beta-lactamase is an integral step in the development of M. xanthus and that this induction is likely to play a role in aggregation and in the restructuring of peptidoglycan which occurs during the differentiation of spores. In support of this hypothesis, we show that exogenous induction of beta-lactamase can rescue aggregation and sporulation of certain mutants. Fruiting body spores from a rescued mutant are indistinguishable from wild-type fruiting body spores when examined by transmission electron microscopy. These results show that the signal transduction pathway leading to the induction of beta-lactamase plays an important role in aggregation and sporulation in M. xanthus.  (+info)

Beta-cyanoalanine synthase: purification and characterization. (5/293)

Beta-cyano-L-alanine synthase [L-cysteine hydrogen-sulfide-lyase (adding HCN), EC 4.4.1.9] was purified about 4000-fold from blue lupine seedlings. The enzyme was homoegeneous on gel electrophoresis and free of contamination by other pyridoxal-P-dependent lyases. The enzyme has a molecular weight of 52,000 and contains 1 mole of pyridoxal-P per mole of protein; its isoelectric point is situated at pH 4.7. Its absorption spectrum has two maxima, at 280 and 410 nm. L-Cysteine is the natural primary (amino acid) substrate; beta-chloro- and beta-thiocyano can serve (with considerably lower affinity) instead of cyanide as cosubstrates for cyanoalanine synthase. The synthase is refractory to DL-cycloserine and D-penicillamine, potent inhibitors of many pyridoxal-P-dependent enzymes. Cyanoalanine synthase catalyzes slow isotopic alpha-H exchange in cysteine and in end-product amino acids; the rates of alpha-H exchange in nonreacted (excess) cysteine are markedly increased in the presence of an adequate cosubstrate; no exchange is observed of H atoms in beta-position.  (+info)

A possible involvement of ion transporter in tumor necrosis factor alpha and cycloheximide-induced apoptosis of endothelial cells. (6/293)

We examined the tumor necrosis factor alpha (TNFalpha)-induced apoptosis of vascular endothelial cells from the standpoint of ion channels. Cultured vascular endothelial cells from bovine carotid artery were used. Apoptosis was determined by a propidium iodide assay. Treatment of the endothelial cells with TNFalpha and cycloheximide for 6 h induced nuclear fragmentation in a TNFalpha dose-dependent manner (1-10 ng/ml). Concomitant treatment of endothelial cells with TNFalpha at a dose of 10 ng/ml and cycloheximide at a dose of 10 microg/ml elicited endothelial cell apoptosis as high as 23.4+/-4.1% at 6 h after administration. However, 10 ng/ml TNFalpha alone elicited a little apoptosis at 6 h after its administration (% apoptosis=4.1+/-0.8%). Cycloheximide (10 microg/ml) did not induce apoptosis at all. Concomitant treatment of endothelial cells with 1 mmol/l of 4,4-diisothiocyanatostilbene-2,2-disulfonic acid, which is a chloride bicarbonate exchanger blocker, partially inhibited the TNFalpha and cycloheximide-induced endothelial cell apoptosis. On the other hand, endothelial cell apoptosis due to TNFalpha and cycloheximide was completely inhibited by benzyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzene (50 micromol/l), an inhibitor of caspase. Moreover, pyrrolidine dithiocarbanate, an inhibitor of nuclear factor kappa B (NF-kappaB), also suppressed endothelial cell apoptosis induced by TNFalpha and cycloheximide completely. These findings suggest that the endothelial cell apoptosis induced by TNFalpha and cycloheximide is closely related to not only chloride ions, but also both NF-kappaB and caspase activation. That is to say, there is a possibility that chloride ions or bicarbonate (pH) may play an important role in signal transduction such as NF-kappaB and caspase activation in the apoptosis induced by TNFalpha and cycloheximide.  (+info)

Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin. (7/293)

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.  (+info)

Intracellular modulation of NMDA receptor function by antipsychotic drugs. (8/293)

The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both the conventional antipsychotic drug haloperidol and the atypical antipsychotic drug clozapine mediate gene expression via intracellular regulation of NMDA receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate that the intraneuronal signal transduction pathway activated by haloperidol, the cAMP pathway, leads to phosphorylation of the NR1 subtype of the NMDA receptor at (897)Ser. Haloperidol treatment is likewise shown to increase (897)Ser-NR1 phosphorylation in rats in vivo. Mutation of (896)Ser and (897)Ser to alanine, which prevents phosphorylation at both sites, inhibits cAMP-mediated gene expression. We conclude that antipsychotic drugs have the ability to modulate NMDA receptor function by an intraneuronal signal transduction mechanism. This facilitation of NMDA activity is necessary for antipsychotic drug-mediated gene expression and may contribute to the therapeutic benefits as well as side effects of antipsychotic drug treatment.  (+info)

The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers | SpringerLinkThe partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers | SpringerLink
D-Cycloserine, a partial agonist of the glycine recognition site of the N-methyl- D-aspartate ( NM DA) receptor, may serve as a probe for human cerebral NM DA receptor function. Since NM DA receptors
https://link.springer.com/article/10.1007%2Fs002130050662
Cycloserine (CAS 68-41-7) Market Research Report 2017Cycloserine (CAS 68-41-7) Market Research Report 2017
Cycloserine (CAS 68-41-7) Market Research Report 2017 aims at providing comprehensive data on cycloserine market globally and regionally (Europe, Asia,
https://marketpublishers.com/report/industry/chemicals_petrochemicals/cycloserine_68-41-7_market_research_report.html
CYCLOSERINE - ORAL (Seromycin) side effects, medical uses, and drug interactions.CYCLOSERINE - ORAL (Seromycin) side effects, medical uses, and drug interactions.
Consumer information about the medication CYCLOSERINE - ORAL (Seromycin), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug CYCLOSERINE - ORAL.
https://www.medicinenet.com/cycloserine_capsule_oral/article.htm
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[150 Pages Report] Check for Discount on 2016 Global and Chinese L-Cycloserine (CAS 339-72-0) Industry Market Research Report report by Prof Research. The Global and Chinese L-Cycloserine Industry, 2011-2021 Market...
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Cycloserine Dimer CL4 Impurity | CAS No. 16337-02-3 - Veeprho : Reference Standards Manufacturer.Cycloserine Dimer CL4 Impurity | CAS No. 16337-02-3 - Veeprho : Reference Standards Manufacturer.
Veeprho manufactures and supplies Cycloserine Dimer CL4 Impurity (CAS No. 16337-02-3) of certified standard. Veeprho has more than 5000 impurities in stock.
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Cycloserine | Johns Hopkins ABX GuideCycloserine | Johns Hopkins ABX Guide
Cycloserine answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540149/all/Cycloserine?q=Cycloserine
Augmentation of Psychotherapy With D-Cycloserine in Agoraphobia - Full Text View - ClinicalTrials.govAugmentation of Psychotherapy With D-Cycloserine in Agoraphobia - Full Text View - ClinicalTrials.gov
The present study is a multicenter study with two participating institutions: The Klinik für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin and the ZPHU - Zentrum für Psychotherapie am Institut für Psychologie, Humboldt-Universität zu Berlin. It is a randomized, placebo-controlled and double blind study with agoraphobic patients receiving a manualized cognitive behavioral therapy. The randomization and blindness refers to medication with an antibiotic called D-Cycloserine: One group receives D-Cycloserine after exposure sessions and the other group is treated with a placebo. The aim is to find out, whether or not D-Cycloserine augments psychotherapy outcome when administered after an exposure. Altogether, 78 patients will be treated. Before therapy, all patients receive a clinical examination to ensure that no contraindications for participating (like cardiac defects or serious central nervous system diseases) are present. In the following diagnostic sessions ...
https://clinicaltrials.gov/ct2/show/NCT01928823?recr=Open&cond=%22Agoraphobia%22&rank=1
Timeline of events during each exposure session. Abbrev | Open-iTimeline of events during each exposure session. Abbrev | Open-i
Timeline of events during each exposure session. Abbreviations: CS, contrast sensitivity vision test; Guess, exposure guess questionnaire; NES, Continuous Perfo
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199294_ehp0116-000078f2&req=4
Plus itPlus it
D-Cycloserine is a competitive inhibitor of alanine racemase for which its Ki is 100 times smaller than the Km for either of the substrates, D- and L-alanine. L-Cycloserine, however, does not inhibit this enzyme. A hypothesis is proposed, based on molecular models, that D-cycloserine has the conformation required of the substrates on the enzyme surface. L-Cycloserine cannot have this conformation.. ...
http://molpharm.aspetjournals.org/content/2/1/92
Oxamicina - Antibiotics, ATC:J04AB01Oxamicina - Antibiotics, ATC:J04AB01
Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria ...
https://pharmacycode.com/Oxamicina.html
سیکلوسرین - ویکی‌پدیاسیکلوسرین - ویکی‌پدیا
سیکلوسرین (آیوپاک آدی: (R)-4-Amino-1,2-oxazolidin-3-one, اینگیلیسجه: Cycloserine, عربجه: سيكلوسيرين‎، روسجا: Циклосерин) بیر شیمیایی بیلشیک دواء. بۇ دواءنین مول جرمیسی مول/قرم ۱۰۲٫۰۹۲ دیر. متابولیسمی قاراجییرده باش وئریر. سیکلوسرین آنتی‌بیوتیک‌ اۆچون ایستیفاده اوْلونور. ...
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Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia - Tabular View -...Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia - Tabular View -...
The change from baseline to week 8 on the positive symptom sub-scale of the Positive and Negative Syndrome Scale (PANSS). Total PANSS positive symptom sub-scale scores range from 7-49. The PANSS positive symptom sub-scale is comprised of 7 items rated on a scale of 1-7: delusions, conceptual disorganization, hallucinatory behavior, excitement, grandiosity, suspiciousness/persecution, and hostility. A score of one on each item 1 absent, 2 is minimal, 3 is mild, 4 is moderate, 5 is moderately severe, 6 is severe, and 7 is extreme. The total score was computed by adding all the items on the sub-scale together. To compute change in scores, week 8 scores were subtracted from baseline scores, resulting in a change score. Higher values equals greater improvement (i.e. week 8 score was lower than baseline score ...
https://clinicaltrials.gov/ct2/show/record/NCT00455702
D-Cycloserine for anxiety disorders
D-cycloserine, an established treatment modality for tuberculosis, is an N-methyl-D-aspartic acid (NMDA) receptor agonist currently being investigated for the treatment of anxiety disorders. The goal of treatment with D-cycloserine is to reduce the frequency and intensity of symptoms associated with anxiety disorders, and to improve patient functioning and quality of life. ...
https://www.crd.york.ac.uk/CRDWeb/ShowRecord.asp?AccessionNumber=32010000853&AccessionNumber=32010000853
Patent US5061721 - Composition containing d-cycloserine and d-alanine for memory and learning ... - Google PatentsPatent US5061721 - Composition containing d-cycloserine and d-alanine for memory and learning ... - Google Patents
A composition is described for use in memory and learning enhancement or for treatment of a cognitive disorder or a psychotic disorder. This composition contains the compound D-cycloserine and D-alanine and provides reduced adverse side effects typically associated with chronic D-cycloserine use.
http://www.google.com/patents/US5061721?dq=6462713
2016 August | microrna inhibitor
84 However, because it is likely that many patients in the positive trials of DCS in anxiety disorders were taking serotonin reuptake inhibitors, it is hard to know how important this variable is because the database is just not large enough to. allow an adequate evaluation of this variable. In our own study of fear of heights we could find no relationship. DCS shows tolerance DCS also failed to facilitate extinction in rats given prior daily injections of DCS,85 consistent with several preclinical studies showing tolerance with repeated DCS treatment.85 Inhibitors,research,lifescience,medical Hence, we suggest spacing DCS treatments by at least a week. DCS should not be given too far in advance of psychotherapy As Inhibitors,research,lifescience,medical mentioned above, DCS is known to facilitate. consolidation of fear extinction so it is important not to give it too early prior to psychotherapy. In fact, post-extinction training is used routinely in rodent studies and this maybe especially ...
http://micrornainhibitor.com/2016/08
D-cycloserine does not improve CBT for social anxiety disorder, but may accelerate early treatment gainsD-cycloserine does not improve CBT for social anxiety disorder, but may accelerate early treatment gains
Kathryn Walsh highlights an RCT showing that D-cycloserine does not improve treatment response when added to a full course of CBT for social anxiety
https://www.nationalelfservice.net/mental-health/anxiety/d-cycloserine-does-not-improve-cbt-for-social-anxiety-disorder-but-may-accelerate-early-treatment-gains/
RCSB PDB - 1MDZ: Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5 phosphate Structure...RCSB PDB - 1MDZ: Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5 phosphate Structure...
1MDZ: Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
http://www.rcsb.org/pdb/explore/explore.do?structureId=1MDZ
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D-cycloserine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYD-cycloserine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. D-cycloserine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=clinical&ligandId=9489
Progressive PsychiatryProgressive Psychiatry
This is the fourth installment in a series of posts on non-pharmacologic approaches to alcohol and drug abuse. Previous posts reviewed the evidence for weak electrical current for reducing symptoms of opioid and alcohol withdrawal. This post is offered as a concise review of promising herbal and other natural product treatments of alcohol craving and withdrawal, narcotic withdrawal and benzodiazepine withdrawal.. Traditionally used herbal medicines may reduce alcohol craving, lessen alcohol consumption and reduce symptoms of withdrawal. Three herbs are used in Chinese medicine to diminish alcohol craving, lessen alcohol absorption through the gut, or reduce symptoms of withdrawal. Kudzu (Radix puerariae) has been used as a treatment of alcohol abuse and dependence in Chinese medicine for almost 2000 years. Animal studies suggest that Kudzu extract significantly reduces alcohol craving (Keung 1993). A recent placebo-controlled human study found that individuals who had the opportunity to binge ...
http://progressivepsychiatry.com/blog/
2i80 - Proteopedia, life in 3D2i80 - Proteopedia, life in 3D
D-alanine:D-alanine ligase (DDl) is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics. It catalyzes the formation of D-alanine:D-alanine dipeptide, sequentially by using one D-alanine and one ATP as substrates for the first-half reaction, and a second D-alanine substrate to complete the reaction. Some gain of function DDl mutants can use an alternate second substrate, causing resistance to vancomycin, one of the last lines of defense against life-threatening Gram-positive infections. Here, we report the crystal structure of Staphylococcus aureus DDl (StaDDl) and its cocrystal structures with 3-chloro-2,2-dimethyl-N-[4(trifluoromethyl)phenyl]propanamide (inhibitor 1) (Ki=4 microM against StaDDl) and with ADP, one of the reaction products, at resolutions of 2.0, 2.2, and 2.6 A, respectively. The overall structure of StaDDl can be divided into three distinct domains. The inhibitor binds to a hydrophobic pocket at the interface of the ...
http://proteopedia.org/wiki/index.php/2i80
Society for Neuroscience - Memory-Boosting Drug May Help Cocaine Addicts Avoid RelapseSociety for Neuroscience - Memory-Boosting Drug May Help Cocaine Addicts Avoid Relapse
The new results show that extinction therapy, in conjunction with D-cycloserine, could combat relapse due to cues, even in new environments. The authors also found that the medication acted primarily on a brain region called the nucleus accumbens, an area associated with drug addiction and the formation of drug-related memories. D-cycloserine acts at specific kinds of receptors for the neurotransmitter glutamate, a chemical that plays a key role in learning and memory ...
https://www.sfn.org/publications/latest-news/2010/08/03/memory-boosting-drug-may-help-cocaine-addicts-avoid-relapse
Enhancing Panic and Smoking Reduction Treatment with D-Cycloserine - Michael OttoEnhancing Panic and Smoking Reduction Treatment with D-Cycloserine - Michael Otto
Approximately 9-15 million smokers in the U.S. meet criteria for at least one anxiety disorder during their lifetime (Kessler et al., 2005) and these persons ex...
http://grantome.com/grant/NIH/R34-DA034658-03
Detecting folding motifs and similarities in protein structuresDetecting folding motifs and similarities in protein structures
P2 MYELIN PROTEIN; D-ALANINE LIGASE; RELATE 2 SETS; 3-DIMENSIONAL STRUCTURE; DATA-BANK; RIBONUCLEOTIDE REDUCTASE; TRANSPORT PROTEINS; BINDING PROTEIN; ALIGNMENT; REFINEMENT ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:107415
r17) Barrick Lab :: ProtocolsFluctuationTestsr17) Barrick Lab :: ProtocolsFluctuationTests
REL606-derived strains are resistant to streptomycin and phage T6. If using D-cycloserine, minimal medium is necessary. For these experiments we generally use 12 selective plates and 3 count plates per test strain. This is sufficient for resolving differences in mutation rates on the order of 10-fold. For measuring differences in mutation rate that are only 2- to 3-fold, we generally scale this up to 48 selective plates and 12 count plates per test strain. Making accurate comparisons of mutation rates on this scale is difficult. When comparing two strains and looking for very small changes, fluctuation tests for all strains should be done at the same time to avoid any number of confounding factors such as subtle differences in media, how long plates are incubated, whether very small colonies are counted as mutants, etc. Freshly prepared antibiotic and phage stocks should always be used. ...
http://barricklab.org/twiki/bin/view/Lab/ProtocolsFluctuationTests?rev=17
Cycloserine capsules - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Visit your doctor or health care professional for regular check ups. You will need blood work done regularly.. You may need to take vitamin supplements while on this medicine. Talk to your doctor about the foods you eat and the vitamins you take.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. ...
http://www.ahealthyme.com/RelatedItems/121,308
Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial ...Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial ...
Preliminary animal research suggests that yohimbine hydrochloride, a selective competitive alpha2-adrenergic receptor antagonist, accelerates fear extinction and converts ineffective extinction regimens (long intertrial intervals) to effective ones. This randomized placebo controlled study examined the potential exposure enhancing effect of yohimbine hydrochloride in claustrophobic humans. Participants (71% undergraduate students and 29% community volunteers) displaying marked claustrophobic fear (n = 24) were treated with 2 1-h in vivo exposure sessions. Participants were randomly allocated to take 10.8 mg yohimbine hydrochloride (n = 12) or placebo (n = 12) prior to each exposure session. Outcome measures included peak fear during a behavioral avoidance task, the Claustrophobia Questionnaire, and the Claustrophobic Concerns Questionnaire. Results showed that both conditions improved significantly at post-treatment with no significant difference between groups. Consistent with prediction the ...
http://dare.uva.nl/search?metis.record.id=315375
DermIS - Vitamin B6 Deficiency (information on the diagnosis)
A nutritional condition produced by a deficiency of PYRIDOXINE in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhoea, anemia, and seizures. Increasingly recognized as a cause is prolonged therapy with certain medications, among them isoniazid, cycloserine, and L-dopa. (From Cecil Textbook of Medicine, 19th ed, p1175). ...
http://dermis.net/dermisroot/en/23869/diagnosep.htm
Treatments
Posted by Steven J. Seay, Ph.D. in Medication, Obsessive-compulsive disorder (OCD) As someone who has long been enamored with basic science, I find it fascinating when classic medications are re-purposed in surprising ways. One of the newest examples of this is the use of D-cycloserine (also known as Seromycin) in the treatment of obsessive-compulsive disorder (OCD). Whats interesting about D-cycloserine is not so much what it is…but what it isnt: D-cycloserine is neither an SRRI nor any other type of antidepressant (e.g., Prozac). Its not an anti-anxiety medication (e.g., Xanax, Klonopin). Its not even an atypical antipsychotic (e.g., Abilify, Risperdal). If its not one of the above, then what is it? The answer might surprise you. Seromycin is actually an antibiotic that was originally developed to help fight off tuberculosis. Whats exciting about using an antibiotic to treat OCD is that its not subject to the same side effects as other medications (i.e., the SSRIs, anxiolytics, or ...
http://www.psychologyandbehavior.com/category/treatments/
EMF-Portal | GSM and DCS Wireless Communication Signals: Combined Chronic Toxicity/Carcinogenicity Study in the Wistar Rat.EMF-Portal | GSM and DCS Wireless Communication Signals: Combined Chronic Toxicity/Carcinogenicity Study in the Wistar Rat.
Each exposure session was divided into three phases of 40 min: (1) GSM Basic (non-DTX) mode with one slot active per basic frame and each 26th basic frame idle. (2) GSM Talk mode consisting of temporal changes between the non-DTX (average 10.8 s) and DTX (average 5.6 s) modes. (3) GSM Environment mode consisting of a GSM Talk signal further amplitude-modulated by a power control function statistically based on measurements performed by France Telecom [Wiart et al., 2000]. The peak (slot-averaged) SAR level for all three phases was the same, however, the resulting average SARs varied: 100% (GSM Basic), 70% (GSM Talk), and 26% (GSM Environment). The SAR values indicated above are those for GSM Basic. The SAR levels in the GSM study had to be decreased in three steps over time since the body weight increase of the rats was greater than predicted and the available power was insufficient to maintain 4 W/kg. So, the SAR (GSM Basic) averaged over the entire exposure period was only 3.7 W/kg for the ...
https://www.emf-portal.org/de/article/15120
EMF-Portal | GSM and DCS Wireless Communication Signals: Combined Chronic Toxicity/Carcinogenicity Study in the Wistar Rat.EMF-Portal | GSM and DCS Wireless Communication Signals: Combined Chronic Toxicity/Carcinogenicity Study in the Wistar Rat.
Each exposure session was divided into three phases of 40 min: (1) GSM Basic (non-DTX) mode with one slot active per basic frame and each 26th basic frame idle. (2) GSM Talk mode consisting of temporal changes between the non-DTX (average 10.8 s) and DTX (average 5.6 s) modes. (3) GSM Environment mode consisting of a GSM Talk signal further amplitude-modulated by a power control function statistically based on measurements performed by France Telecom [Wiart et al., 2000]. The peak (slot-averaged) SAR level for all three phases was the same, however, the resulting average SARs varied: 100% (GSM Basic), 70% (GSM Talk), and 26% (GSM Environment). The SAR values indicated above are those for GSM Basic. The SAR levels in the GSM study had to be decreased in three steps over time since the body weight increase of the rats was greater than predicted and the available power was insufficient to maintain 4 W/kg. So, the SAR (GSM Basic) averaged over the entire exposure period was only 3.7 W/kg for the ...
https://www.emf-portal.org/en/article/15120
D-Cycloserine
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
http://www.chemicaldictionary.org/dic/D/D-Cycloserine_834.html
Sequence Similarity Search - BLAST
bts:Btus_1041 K01921 D-alanine-D-alanine ligase [EC:6.3.2.4] , (GenBank) D-alanine/D-alanine ligase (A) MKKLIAVIFGGRSVEHEVSIVTAQQIMYQLRRDLYDVMPLYIDKEGAWWTGDVLAKLESF KAANRNAALAQAARVIVVPTPGGGVIEDPQALRGLFRKPRRWTPDVAILATHGTYGEDGC LQGLLEIAGIPYTGPGVLGSAVGMDKILMKDVFRAQGIPVVNYIWIHRDEWHEHPDEVAD RVERELQYPVFVKPSNLGSSVGIGRAEDRDGLFHAMDVAAGYDRRLLIEQGVVSPREINC SVLADGQDLRVSLCEEPVSWEAFLSYEDKYIRGNFTKGQTGRRIPADLPDGVTEAVQELA RRAFRAIQARGVARVDFLLSPDGSIYVNEINTIPGSLSFYLWEPSGVSFPDLLDKLIEDA LADYRDKSRNISTYDTDLIEQFGRGGKVGSKASPQTS ...
http://www.genome.jp/tools-bin/search_sequence?prog=blast&seqid=bts:Btus_1041+aa
Sequence Similarity Search - BLAST
cwo:Cwoe_4917 K01921 D-alanine-D-alanine ligase [EC:6.3.2.4] , (GenBank) D-alanine/D-alanine ligase (A) MKALVAYGGRSLEREVSARSGQQAAKALRQLGHAVELIDVGADFVDVVQRAEPDFVFIAL HGVGGEDGTVQDLLEILQVPYTGSDALASALCLDKHTFKSVCELRGVPTPPWHSFTKQAF ADYGAGKTLDALWQQFDGRAVVKPARQGSSFGLSVVQERAQLGGAVLGAMSYDDRVLLER YVPGRELAVTVLGRSDAPEPLPVVEIVMASEEYYSFQAHYEIGQSEVRLAGLPDAVDAHV RAIAAEAYSAAGCRDFARVDIRLEGDEPWVLEINTIPGLTETGPTPLAAEHAGLTFAQLI ERISARVVG ...
http://www.genome.jp/tools-bin/search_sequence?prog=blast&seqid=cwo:Cwoe_4917+aa
August 2019 - lightllightt0 xyz
d-Cycloserine enhanced the incorporation of (14)C-l-alanine at when will cialis go generic all times in the developmental cycle, but the incorporation of (14)C-l-lysine was always inhibited. Effects of dHGF on transplanted livers treated with low-dose tacrolimus were investigated. Activity-dependent changes of ...
http://lightllightt0.xyz/2019/08/
Tuberculosis: Study describes new mutations in drug resistance - IHMT
A recent study, now published in the highly regarded scientific journal Nature Genetics, considerably expands the present body of knowledge concerning the genetic determinants of drug resistance in M. tuberculosis. In this study, new genetic mutations associated with important second-line drugs for multidrug resistant tuberculosis treatment regimens such as cycloserine, ethionamide and para-amino salicylic acid are described. Also, the study identifies novel interactions between drug resistance associated genes that may contribute to increased resistance levels and, also highlights the role of efflux pumps (membrane proteins specialized in molecular transport) in the development of drug resistance across this bacterial species.. Beyond the more comprehensive and deeper knowledge on M. tuberculosis resistance mechanisms conveyed by this new data, it will enable the inclusion of specific markers for drug resistance in new rapid molecular diagnosis tests, envisioning an increase in sensitivity and ...
http://www.ihmt.unl.pt/en/tuberculosis-study-describes-new-mutations-in-drug-resistance/
JENIS OBAT KERAS : Antibiotik « Catfish FabricationJENIS OBAT KERAS : Antibiotik « Catfish Fabrication
Keputusan Menteri Kelautan dan Perikanan Nomor: KEP.20/MEN/2003 Tentang Klasifikasi Obat Ikan. Antibiotika tersebut di bawah ini serta derivat-derivat dan garam-garamnya : 1. Albucid, sodium; 2. Ampicillin, sodium; 3. Ampicillin Thrihydrate; 4. Aureomycin; 5. Bacitracin; 6. Carbenicilin disodium; 7. Cephaloridine; 8. Chlortetracycline; 9. Cloxacillin, sodium; 10. Colistin Sulfate; 11. Cycloserine; 12. Doxycline Hyclate; 13. Emtrysidina; 14.…
https://empangqq.com/2015/08/06/jenis-obat-keras-antibiotik/
Analytical Profiles of Drug Substances, Vol. 1 by FLOREY KLAUS - Portret de voluntar Book Archive
The method involves the selective extraction of the compound into ether, hydrolysis tb the 2-amino-5-chlorobenzophenone and subsequent determination by gas-liquid chromatography. The GLC of unhydrolyzed chlordiazepoxide has been reported by Martin and Street2 using acid-washed chromosorb W coated with dimethyldichlorosilane. The reported column temperature for chlordiazepoxide was 245C. 3) B Ch 1o rofom :me th ano1 (1O:l) B Ethylacetate:ethanol (9:l) B Benzene:dioxane: 28% ammonium hydroxide A Acetone: cyclohexane: ethanol (4:4:2) A Benzene:acetone (4:l) A Methano1:acetone: ammonium hydroxide (50 :50:1) A Benzene:ethanol:25% ammonium hydroxide (50:10:5) A Adsorbant: I 48 48 29 57 46 - Detection w2 54 254 254 2 54 w254 w254 38 Reference 22 22 22 22 22 23 w254 23 Dragendorff Reagent 24 27 II 24 41 11 24 78 64 A. Personal Communication. 9. , Personal Communication. 10. MacMullan, E . A . , Personal Communication. 51 G, 523 (1967). CYCLOSERINE J. Lamb 53 J. W. LAMB C OI; 1. 2. 3. 4. 5. 6. 7. 53 ...
http://portretdevoluntar.provobis.ro/read/analytical-profiles-of-drug-substances-vol-10-1-editon
Essentiality of Mycobacterium tuberculosis D-alanine racemase - Ofelia ChaconEssentiality of Mycobacterium tuberculosis D-alanine racemase - Ofelia Chacon
Mycobacterium tuberculosis (Mtb), the main etiologic agent of human tuberculosis (TB), remains a leading cause of worldwide morbidity and mortality. The percent...
https://grantome.com/grant/NIH/R21-AI087561-02
The efficacy of brief periods of reverse occlusion in promoting recovery from the physiological effects of mononuclear...The efficacy of brief periods of reverse occlusion in promoting recovery from the physiological effects of mononuclear...
The relative effect of short daily periods of reverse occlusion in promoting recovery from the physiological effect of monocular deprivation in kittens were examined with a view to identifying a neurophysiological basis for the visual improvement observed with minimum occlusion therapy in amblyopia. Kittens were monocularly deprived from near birth until 5 weeks of age, at which time they were reverse-sutured and housed in total darkness. Each kitten received a short period of visual exposure through its initially deprived eye each day for either a fixed number of days or for a constant total visual exposure spread over a different number of exposure sessions. Electrophysiological recordings from single cells in the visual cortex were made the day after the last visual exposure. Kittens that received daily periods of reverse occlusion as brief as 30 min for 20 days showed a substantial degree of reversal of cortical ocular dominance. Other experiments indicated that 20 hr of reverse occlusion ...
https://iovs.arvojournals.org/article.aspx?articleid=2176316
Incorporating the Judicious Use of Safety Behavior Into Exposure-Based Treatments for Anxiety Disorders: A Study of Treatment...Incorporating the Judicious Use of Safety Behavior Into Exposure-Based Treatments for Anxiety Disorders: A Study of Treatment...
Milosevic, Irena and Radomsky, Adam S. (2013) Incorporating the Judicious Use of Safety Behavior Into Exposure-Based Treatments for Anxiety Disorders: A Study of Treatment Acceptability. Journal of Cognitive Psychotherapy, 27 (2). pp. 155-174. ISSN 08898391 ...
https://spectrum.library.concordia.ca/977665/
Immunology] searching for data on extinction coefficients for equine seric Fab, F(ab)2Immunology] searching for data on extinction coefficients for equine seric Fab, F(ab)2
Dear all, I would like to know about extinction coefficients for equine seric Fab, F(ab)2. Did you find it before? How did you get it? Thank you in advance Susan ...
http://www.bio.net/bionet/mm/immuno/2009-July/018106.html
Cell Wall Inhibitors Antibiotics FlashcardsCell Wall Inhibitors Antibiotics Flashcards
broad spectrum of activity against gram positive, gram negative, and pseudomonas sp; stable against most beta-lactamases; generally reserved for treatment of nosocomial, multidrug-resistant infections, and febrile neutropenia ...
https://www.flashcardmachine.com/cell-wallinhibitorsantibiotics.html
Bedaquiline - Drugs.comBedaquiline - Drugs.com
Bedaquiline is a medicine available in a number of countries worldwide. A list of US medications equivalent to Bedaquiline is available on the Drugs.com website.
https://www.drugs.com/international/bedaquiline.html
Bedaquiline (Sirturo) | Daviss Drug GuideBedaquiline (Sirturo) | Daviss Drug Guide
Find information on Bedaquiline (Sirturo) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109864/all/bedaquiline
CycloserineCycloserine
Under mildly acidic conditions, cycloserine hydrolyzes to give hydroxylamine and D-serine. Cycloserine can be conceptualized as ... Cycloserine is similar in structure to the amino acid D-alanine and works by interfering with the formation of the bacteria's ... Cycloserine was discovered in 1954 from a type of Streptomyces. It is on the World Health Organization's List of Essential ... Cycloserine works as an antibiotic by inhibiting cell-wall biosynthesis in bacteria. As a cyclic analogue of D-alanine, ...
https://en.wikipedia.org/wiki/Cycloserine
Ligand-gated ion channelLigand-gated ion channel
D-cycloserine; L-aspartate; quinolinate, etc. Partial agonists : N-methyl-D-aspartic acid (NMDA); NRX-1074; 3,5-dibromo-L- ...
https://en.wikipedia.org/wiki/Ligand-gated_ion_channel
List of investigational antidepressantsList of investigational antidepressants
"Cycloserine/lurasidone - NeuroRx". adisinsight.springer.com. Retrieved 7 May 2017. "Deudextromethorphan". adisinsight.springer. ... Cycloserine/lurasidone (NRX-101; Cyclurad) - NMDA receptor glycine site partial agonist and AA combination - specifically under ...
https://en.wikipedia.org/wiki/List_of_investigational_antidepressants
Karl August FolkersKarl August Folkers
His team also isolated the antibiotic cycloserine. In 1958 his Merck team determined the structure of coenzyme Q10. He later ...
https://en.wikipedia.org/wiki/Karl_August_Folkers
Mycobacterium malmoenseMycobacterium malmoense
Susceptible to ethambutol, ethionamide, kanamycin and cycloserine. Differential characteristics Antigenic structure: ...
https://en.wikipedia.org/wiki/Mycobacterium_malmoense
2-Oxazolidone2-Oxazolidone
Cycloserine is a second line drug against tuberculosis. Note that cycloserine, while technically an oxazolidone, has a ... The first ever used oxazolidinone was cycloserine (4-amino-1,2-oxazolidin-3-one), a second line drug against tuberculosis since ...
https://en.wikipedia.org/wiki/2-Oxazolidone
Streptomyces virginiaeStreptomyces virginiae
... produces actithiazic acid, virginiamycins and cycloserine. Streptomyces virginiae also produces monensin ...
https://en.wikipedia.org/wiki/Streptomyces_virginiae
EthionamideEthionamide
When taken with cycloserine, seizures have been reported. High rates of hepatotoxicty have been reported when taken with ...
https://en.wikipedia.org/wiki/Ethionamide
Traumatic memoriesTraumatic memories
D-cycloserine is a chemical which enhances (agonist) the activity of the NMDA receptors. When used in rats, D-cycloserine was ... "Facilitation of Extinction of Conditioned Fear by D-Cycloserine. Implications for Psychotherapy". Current Directions in ...
https://en.wikipedia.org/wiki/Traumatic_memories
Mycobacterium bohemicumMycobacterium bohemicum
Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...
https://en.wikipedia.org/wiki/Mycobacterium_bohemicum
TerizidoneTerizidone
It is a derivate of cycloserine and it is bacteriostatic. Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, ...
https://en.wikipedia.org/wiki/Terizidone
AdolescenceAdolescence
Effects of D-Cycloserine". Neuropsychopharmacology. 35 (10): 2134-2142. doi:10.1038/npp.2010.92. PMC 3055297. PMID 20592716. ...
https://en.wikipedia.org/wiki/Adolescence
Tuberculosis managementTuberculosis management
... prothionamide cycloserine (WHO group 4) terizidone (WHO group 5) Third-line drugs (WHO group 5) include drugs that may be ... cycloserine); or it may be effective, but unavailable in many developing countries (e.g., fluoroquinolones):[citation needed] ... Cycloserine (80-100%) Ethionamide (100%) PAS (10-50%) (inflamed meninges only) The use of steroids is routine in TB meningitis ...
https://en.wikipedia.org/wiki/Tuberculosis_management
Social anxiety disorderSocial anxiety disorder
It has been shown that a combination of acute dosing of d-cycloserine (DCS) with exposure therapy facilitates the effects of ... Hofmann SG, Pollack MH, Otto MW (2006). "Augmentation Treatment of Psychotherapy for Anxiety Disorders with D-Cycloserine". CNS ... March 2006). "Augmentation of exposure therapy with D-cycloserine for social anxiety disorder". Arch. Gen. Psychiatry. 63 (3): ...
https://en.wikipedia.org/wiki/Social_anxiety_disorder
D-alanine-D-alanine ligaseD-alanine-D-alanine ligase
Phosphinate and D-cycloserine are known to inhibit this enzyme. The N-terminal region of the D-alanine-D-alanine ligase is ...
https://en.wikipedia.org/wiki/D-alanine—D-alanine_ligase
Mycobacterium hassiacumMycobacterium hassiacum
Susceptible to some antibiotics, including streptomycin, ethambutol, cycloserine, ciprofloxacin and clarithromycin. Resistant ...
https://en.wikipedia.org/wiki/Mycobacterium_hassiacum
AilurophobiaAilurophobia
D-cycloserine has been linked to facilitating better results in exposure therapy. Dorothy L. Sayers twice made use of ... "D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic ...
https://en.wikipedia.org/wiki/Ailurophobia
Blastopirellula marinaBlastopirellula marina
It's "resistant to ampicillin, penicillin, cephalothin, streptomycin, and cycloserine, but not tetracycline." Six strains have ...
https://en.wikipedia.org/wiki/Blastopirellula_marina
Cell envelope antibioticCell envelope antibiotic
Examples include cycloserine, penicillin, and polymyxin B. "Antibiotics that affect the cell envelope". v t e (Articles with ...
https://en.wikipedia.org/wiki/Cell_envelope_antibiotic
Specific phobiaSpecific phobia
As of 2020, studies on the use of adjunct d-cycloserine are inconclusive. The majority of those that develop a specific phobia ... There are some findings suggesting that adjuvant use of the NMDA receptor partial agonist, d-cycloserine, with virtual reality ...
https://en.wikipedia.org/wiki/Specific_phobia
List of biochemistsList of biochemists
Karl August Folkers (1906-1997). American biochemist at Merck, known for work on the antibiotics cathomycin and cycloserine. ...
https://en.wikipedia.org/wiki/List_of_biochemists
Stefan HofmannStefan Hofmann
Hofmann has shown that d-cycloserine, a partial agonist of the glutamate receptor can augment extinction learning and speed up ... doi:10.1038/mp.2015.109 Hofmann, S. G. (2016). Schrödinger's cat and d-cycloserine to augment exposure therapy - both are dead ... Hofmann, Stefan (2016). "Schrödinger's cat and d-cycloserine to augment exposure therapy - both are dead and alive". JAMA ... ". "Cognitive Therapy and Research". Hofmann, Stefan G. (March 2014). "D-cycloserine for Treating Anxiety Disorders: Making ...
https://en.wikipedia.org/wiki/Stefan_Hofmann
GABA transaminase inhibitorGABA transaminase inhibitor
... and L-cycloserine. Certain members of this class are used as anticonvulsants. Ciesielski, L.; Simler, S.; Gensburger, C.; ... "L-cycloserine: Behavioural and biochemical effects after single and repeated administration to mice, rats and cats". ...
https://en.wikipedia.org/wiki/GABA_transaminase_inhibitor
University of Florida Obsessive Compulsive Disorder ProgramUniversity of Florida Obsessive Compulsive Disorder Program
"A Preliminary Study of D-Cycloserine Augmentation of Cognitive-Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder". ...
https://en.wikipedia.org/wiki/University_of_Florida_Obsessive_Compulsive_Disorder_Program
Aeropyrum pernixAeropyrum pernix
The cells of the organisms are sensitive to chloramphenicol and insensitive to ampicillin, vancomycin, and cycloserine. It ...
https://en.wikipedia.org/wiki/Aeropyrum_pernix
Alanine racemaseAlanine racemase
At least two compounds, 3-Fluoro-D-alanine and D-Cycloserine are known to inhibit this enzyme. The D-alanine produced by ...
https://en.wikipedia.org/wiki/Alanine_racemase
Vitamin B6Vitamin B6
Use of oral contraceptives and treatment with certain anticonvulsants, isoniazid, cycloserine, penicillamine, and ...
https://en.wikipedia.org/wiki/Vitamin_B6
Quinolone antibioticQuinolone antibiotic
... and cycloserine. Administration of quinolone antibiotics to a benzodiazepine-dependent individual can precipitate acute ...
https://en.wikipedia.org/wiki/Quinolone_antibiotic
Mycobacterium branderiMycobacterium branderi
In susceptibility tests the type strain was resistant to isoniazid, rifampin, pyrazinamide, and cycloserine but susceptible to ...
https://en.wikipedia.org/wiki/Mycobacterium_branderi
Mycobacterium mageritenseMycobacterium mageritense
Optimum growth at 30 °C and 37 °C. Resistant to isoniazid, cycloserine, capreomycin, pyrazinamide, and thiosemicarbazone Most ...
https://en.wikipedia.org/wiki/Mycobacterium_mageritense
D-Cycloserine for Social Anxiety: Does Timing Matter?D-Cycloserine for Social Anxiety: Does Timing Matter?
D-cycloserine appears to augment exposure therapy for social anxiety disorder. But does timing of the drug matter? ... D-cycloserine (DCS), an antibiotic that has traditionally been used to treat tuberculosis, appears to augment exposure therapy ... Cite this: D-Cycloserine for Social Anxiety:Does Timing Matter? - Medscape - Jun 04, 2020. ...
https://www.medscape.com/viewarticle/931743
Common and Rare Side Effects for CycloserineCommon and Rare Side Effects for Cycloserine
Find out what health conditions may be a health risk when taken with Cycloserine ... Cycloserine. Common Brand(s): Seromycin Generic Name(s): cycloserine View Free Coupon ... Who should not take Cycloserine? The following conditions are contraindicated with this drug. Check with your physician if you ... Should I avoid certain foods while taking Cycloserine? * What should I know regarding pregnancy, nursing and administering ...
https://www.webmd.com/drugs/2/drug-1054/cycloserine-oral/details/list-contraindications
Deterioration of cycloserine in the tropics*Deterioration of cycloserine in the tropics*
1968)‎. Deterioration of cycloserine in the tropics*. Bulletin of the World Health Organization, 39 (‎5)‎, 781 - 789. https:// ...
https://extranet.who.int/iris/restricted/handle/10665/266493
Cycloserine: Uses, Interactions, Mechanism of Action | DrugBank OnlineCycloserine: Uses, Interactions, Mechanism of Action | DrugBank Online
Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). ... Cycloserine. Cycloserine (250 mg/1). Capsule. Oral. Macleods Pharmaceuticals Limited. 2019-01-18. Not applicable. US. ... Cycloserine may increase the neurotoxic activities of Acetophenazine.. Alimemazine. Cycloserine may increase the neurotoxic ... Cycloserine may increase the neurotoxic activities of Amisulpride.. Amitriptyline. Cycloserine may increase the neurotoxic ...
https://go.drugbank.com/drugs/DB00260
Treatment of Tuberculosis and Tuberculosis Infection in Adults and ChildrenTreatment of Tuberculosis and Tuberculosis Infection in Adults and Children
Cycloserine. Like ethionamide, cycloserine is a bacteriostatic antituberculosis agent that is useful in certain limited ... For this reason 150 mg/d of pyridoxine should be given with cycloserine. Cycloserine interferes with the elimination of ... Cycloserine. Capreomycin. Kanamycin. Thiacetazone. POTENTIALLY EFFECTIVE DRUGS THAT HAVE NOT BEEN WIDELY USED IN THE THERAPY OF ... There is not enough information to determine the risk of cycloserine or ethionamide; they should be avoided if possible. ...
https://wonder.cdc.gov/wonder/prevguid/p0000413/p0000413.asp
CYCLOSERINE â€CEFOXITIN SUPPLEMENTCYCLOSERINE â€"CEFOXITIN SUPPLEMENT
Search
No Effects of D-Cycloserine Enhancement in Exposure with Response Prevention Therapy in Panic Disorder with Agoraphobia: A...No Effects of D-Cycloserine Enhancement in Exposure with Response Prevention Therapy in Panic Disorder with Agoraphobia: A...
Purpose/Background D-cycloserine (DCS) is a partial N-methyl-D-aspartate receptor agonist that potentially augments response to ... No Effects of D-Cycloserine Enhancement in Exposure with Response Prevention Therapy in Panic Disorder with Agoraphobia: A ... No Effects of D-Cycloserine Enhancement in Exposure with Response Prevention Therapy in Panic Disorder with Agoraphobia: A ... Keywords: D-cycloserine, enhancement, panic disorder with agoraphobia, posttreatment, pretreatment, Psychiatry and Mental ...
https://dspace.library.uu.nl/handle/1874/361017
D-Cycloserine (D-CSR) - Krins Life SciencesD-Cycloserine (D-CSR) - Krins Life Sciences
CAS No. 68-41-7 HSN Code : 29379020 IMDG Identification : Not Regulated for Transport (Non-Haz) Molecular Formula : C3H6N2O2 Molecular Weight : 102.09 Storage : 2 to 8°C (Refrigerate) Shelf Life : 60 Months Specifications Appearance (Colour) White to pale yellow Appearance (Form) Powder Potency min. 900 units/mg Not for…
https://www.krinslifescienceslab.ca/product/d-cycloserine-d-csr/
August Testing - Reports | MPEP | Laboratory Information | TB | CDCAugust Testing - Reports | MPEP | Laboratory Information | TB | CDC
Cycloserine. 5. 0. 5. 0. 0. 0. 1. 0. 1†. p-Aminosalicylic acid. 5. 0. 5. 1. 0. 1. 3. 0. 3. ...
https://www.cdc.gov/tb/topic/laboratory/mpep/2021/aug-mpepIsolate.htm
Specimen collection and processing instructions for CYCLOSERINE, LEVEL testSpecimen collection and processing instructions for CYCLOSERINE, LEVEL test
Specimen collection and processing instructions for medical laboratory test CYCLOSERINE, LEVEL at Geisinger Medical Laboratories
https://geisingermedicallabs.com/catalog/details.cfm?tid=2282
Hereditary Coproporphyria Treatment & Management: Approach Considerations, Diet, PreventionHereditary Coproporphyria Treatment & Management: Approach Considerations, Diet, Prevention
Hereditary coproporphyria is one of the porphyrias, a group of diseases that involves defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. Inheritance is autosomal (usually autosomal dominant, but sometimes autosomal recessive).
https://emedicine.medscape.com/article/205374-treatment
Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions between brain regions and behavior...Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions between brain regions and behavior...
Dive into the research topics of Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions ... Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions between brain regions and behavior ...
https://ohsu.pure.elsevier.com/en/publications/opposing-effects-of-d-cycloserine-on-fear-despite-a-common-extinc-2/fingerprints/
Using Cognitive Enhancers to Improve the Treatment of Anxiety Disorders in Young People: Examining the Potential for D...Using Cognitive Enhancers to Improve the Treatment of Anxiety Disorders in Young People: Examining the Potential for D...
This article examines the potential use of D-cycloserine (DCS) to augment exposure-based therapies for anxious young people. ... This article examines the potential use of D-cycloserine (DCS) to augment exposure-based therapies for anxious young people. ... medications like D-cycloserine (DCS) to improve conventional psychological therapies. Exposure therapies relying upon the ... Examining the Potential for D-Cycloserine to Augment Exposure for Child Anxiety. ...
https://research-repository.griffith.edu.au/handle/10072/40867
دی سیکلو سرین 30020 سیگما / D-Cycloserine 30020 Sigma - کیان پرتو تجهیزدی سیکلو سرین 30020 سیگما / D-Cycloserine 30020 Sigma - کیان پرتو تجهیز
Bedaquiline - WikipediaBedaquiline - Wikipedia
The most common side effects of bedaquiline in studies were nausea, joint and chest pain, and headache. The drug also has a black-box warning for increased risk of death and arrhythmias, as it may prolong the QT interval by blocking the hERG channel.[18] Everyone on bedaquiline should have monitoring with a baseline and repeated ECGs.[19] If a person has a QTcF of , 500 ms or a significant ventricular arrythmia, bedaquiline and other QT prolonging drugs should be stopped.[citation needed] There is considerable controversy over the approval for the drug, as one of the largest studies to date had more deaths in the group receiving bedaquiline that those receiving placebo.[20] Ten deaths occurred in the bedaquiline group out of 79, while two occurred in the placebo group, out of 81.[15] Of the 10 deaths on bedaquiline, one was due to a motor vehicle accident, five were judged as due to progression of the underlying tuberculosis and three were well after the person had stopped receiving ...
https://en.wikipedia.org/wiki/Bedaquiline
D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. | Neuropsychopharmacology;40(10): 2357-67, 2015 Sep. |...D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. | Neuropsychopharmacology;40(10): 2357-67, 2015 Sep. |...
Systemic D-cycloserine also selectively reduced intake of quinine-adulterated alcohol, and D-cycloserine inhibited NAcore HA- ... D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats.. Seif, Taban; Simms, Jeffrey A; Lei, Kelly; Wegner, Scott ... D-serine and D-cycloserine, the NMDAR activators at the glycine site, are of particular interest because they have been used in ... cycloserine on this aversion-resistant alcohol intake (that persists despite adulteration with quinine) and consumption of ...
https://pesquisa.bvsalud.org/perinatal/resource/es/mdl-25801502
Niacinamide: MedlinePlus SupplementsNiacinamide: MedlinePlus Supplements
Reversible pellagra-like encephalopathy with ethionamide and cycloserine. Tubercle 1972;53:132. View abstract. ...
https://medlineplus.gov/druginfo/natural/1534.html
Tuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in ChildrenTuberculosis (TB) Treatment & Management: Approach Considerations, Treatment During Pregnancy, Treatment in Children
Tuberculosis (TB) (see the image below), a multisystemic disease with myriad presentations and manifestations, is the most common cause of infectious disease-related mortality worldwide. Although TB rates are decreasing in the United States, the disease is becoming more common in many parts of the world.
https://emedicine.medscape.com/article/230802-treatment
D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome<...
D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome. PloS one. 2017 Aug;12(8):e0183026. doi: ... D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome. In: PloS one. 2017 ; Vol. 12, No. 8. ... D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome. / Na, Elisa S.; De Jesús-Cortés, Héctor; ... Treatment of Mecp2tm1.1Jae/y mice with D-cycloserine (DCS), an FDA-approved analog of the amino acid D-alanine with antibiotic ...
https://utsouthwestern.pure.elsevier.com/en/publications/d-cycloserine-improves-synaptic-transmission-in-an-animal-mode-of
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC. AN - coordinate with specific type of tuberculosis + specific ...
https://decs.bvs.br/I/dcsnew2008.txt
The effect of D-cycloserine on brain processing of breathlessness over pulmonary rehabilitation - an experimental medicine...
The effect of D-cycloserine on brain processing of breathlessness over pulmonary rehabilitation - an experimental medicine ... The effect of D-cycloserine on brain processing of breathlessness over pulmonary rehabilitation - an experimental medicine ...
https://www.expmedndm.ox.ac.uk/publications/1236097?eeee2178-7498-11ed-8577-061b866677b4
Reticular formation and spinal cord injury | Spinal CordReticular formation and spinal cord injury | Spinal Cord
d-Cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry. Pain 2003; 132: 108-123. ...
https://www.nature.com/articles/sc2008105?error=cookies_not_supported&code=58e9683e-3056-4142-8613-0f186acf3447
Fear NotFear Not
Use of D-cycloserine could partially overcome those obstacles, he says.. Davis predicts that the drug could also treat people ... D-cycloserine also binds to the NMDA receptor and, according to animal studies, enhances learning. Physicians have been so ... Injecting D-cycloserine into a rodents bloodstream or amygdala before this training sped up the extinction process, the ... Davis started his investigation of D-cycloserines effect on fear by conditioning rats to associate a foot shock with a bright ...
https://www.sciencenews.org/article/fear-not
Tourettes Syndrome Clinical Research Trials | CenterWatchTourette's Syndrome Clinical Research Trials | CenterWatch
D-cycloserine Augmented Treatment for Youth With Tic Disorders This pilot study aims evaluate the feasibility and initial ... efficacy of behavior therapy augmented by d-cycloserine (DCS) compared to behavior therapy augmented by placebo. After an ...
https://www.centerwatch.com/clinical-trials/listings/condition/148/tourettes-syndrome/?dt_type=updated
Boehm GW[au] - Search Results - PubMedBoehm GW[au] - Search Results - PubMed
Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure. Kranjac D, ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Boehm+GW%5Bau%5D&dispmax=50
Anti-Mycobacteria | GoldBioAnti-Mycobacteria | GoldBio
D-Cycloserine is an amino acid analog antibiotic effective against a wide variety of bacteria. It is commonly used against ... D-cycloserine inhibits a variety of enzymes, is a partial NMDA receptor agonist, and may improve memory and cognition. ...
https://goldbio.com/collection/anti-mycobacteria
Légis QuébecLégis Québec
CYCLOSERINE. CYCLOSPORINE. CYTARABINE AND ITS SALTS. CYTHIOATE Dosage forms for oral use. DACARBAZINE. DACTINOMYCIN. DANAZOL. ...
https://www.legisquebec.gouv.qc.ca/en/document/cr/P-10,%20r.%2012%20/20131219
AntibioticEthambutolAmino acidBacteriaInhibits2017TuberculosisExposureAlcoholEnzymesResistantDepressionDrugWorksIncreaseSiteTreatmentEthionamideAmikacinSeromycinFructose AgarNMDAAgarCell-wall synthesisIsoniazidMycobacteriaAgonistToxicityBroad-spectrum a250mgPharmacokineticsGram-negativeExtinction of fearGlycine siteDrugsFear extinctionEfficacyInhibitorDoseMolecularConcentrationsDeficitsSchizophreniaPlacebo-controlledCognitiveSubunitsFacilitateSevereEffects
Antibiotic10
  • D-cycloserine (DCS), an antibiotic that has traditionally been used to treat tuberculosis, appears to augment exposure therapy (ET) for social anxiety disorder (SAD) regardless of whether it's administered before or after a session, new research suggests. (medscape.com)
  • Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). (drugbank.com)
  • Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. (drugbank.com)
  • Treatment of Mecp2 tm1.1Jae/y mice with D-cycloserine (DCS), an FDA-approved analog of the amino acid D-alanine with antibiotic and glycinergic activity, corrected the presynaptic but not LTP deficit without affecting deficient hippocampal BDNF levels. (elsevier.com)
  • D-Cycloserine is an amino acid analog antibiotic effective against a wide variety of bacteria. (goldbio.com)
  • Led by professor David Roper at the University of Warwick's School of Life Sciences and Dr Luiz Pedro Carvalho from the Francis Crick Institute, a paper published today in Nature Communications reveals a deeper understanding of how the antibiotic D-cycloserine uniquely works at a molecular level. (infectioncontroltoday.com)
  • D-cycloserine is an old antibiotic drug which is effective against many microbial diseases such as tuberculosis, but is often used as a second line treatment, because of some adverse side-effects. (infectioncontroltoday.com)
  • Dr, Luiz Pedro Carvalho, from the Mycobacterial Metabolism and Antibiotic Research Laboratory at the Francis Crick Institute, said, 'Perhaps more important than how D-cycloserine works, this study highlights an increasingly obvious fact: we know much less than we think about how antibiotics really work and how bacteria become resistant. (infectioncontroltoday.com)
  • A longer term goal will be to modify the structure of D-cycloserine, so that it more closely resembles the newly discovered chemical species, and in so doing produce an antibiotic that is more specific and avoids some of adverse side effects of D-cycloserine - enabling its wider use in the fight against antibiotic resistant infections. (infectioncontroltoday.com)
  • Sarah Batson et al, Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine, Nature Communications (2017). (medicalxpress.com)
Ethambutol2
  • On the 20th day of admission, therefore, rifampicin and ethambutol treatments of the girl were stopped, and anti-tuberculosis treatment was readjusted to high doses of isoniazid (15 mg/kg once daily), pyrazinamide (30 mg/kg/day), amikacin (15 mg/kg/day), levofloxacin (10 mg/kg twice daily), linezolid (10 mg/kg twice daily), cycloserine (15 mg/kg once daily) and clofazimine (5 mg/kg once daily) (8). (who.int)
  • Currently the patient was on Isoniazid, Rifampicin, Ethambutol, Pyrazinamide and also on Kanamycin, Clofazimine and Cycloserine since past 3 months. (pediatriconcall.com)
Amino acid1
  • Cycloserine is an analog of the amino acid D-alanine. (drugbank.com)
Bacteria2
  • This is an impression smear photomicrograph of darkly-stained, rod-shaped, Clostridium difficile bacteria, grown on cycloserine-mannitol blood agar. (cdc.gov)
  • Perhaps more important than how D-cycloserine works, this study highlights an increasingly obvious fact: we know much less than we think about how antibiotics really work and how bacteria become resistant. (medicalxpress.com)
Inhibits2
  • D-cycloserine inhibits a variety of enzymes, is a partial NMDA receptor agonist, and may improve memory and cognition. (goldbio.com)
  • The researchers have observed, for the first time, how D-cycloserine inhibits the D-alanine-D-alanine ligase enzyme. (infectioncontroltoday.com)
20171
  • A 2017 meta-analysis of 21 studies found that d-cycloserine was superior to a placebo in boosting the short-term effect of exposure-based therapy, though any long-term effects were less consistent. (maps.org)
Tuberculosis1
  • In other prescription drug news, a huge price hike for tuberculosis drug cycloserine has been withdrawn, the Times reports . (moneytalksnews.com)
Exposure4
  • Purpose/Background D-cycloserine (DCS) is a partial N-methyl-D-aspartate receptor agonist that potentially augments response to exposure therapy in anxiety disorders by enhancing extinction learning. (uu.nl)
  • This article examines the potential use of D-cycloserine (DCS) to augment exposure-based therapies for anxious young people. (edu.au)
  • They randomly assigned the participants to virtual reality exposure (12 weekly sessions of simulated attacks on the World Trade Center combined with patients' recounting their traumatic experience in vivid detail) with either the drug d-cycloserine or a placebo. (maps.org)
  • Subjects who received exposure along with d-cycloserine showed faster and greater improvement in their PTSD and depressive symptoms, and the benefits persisted after six months of follow-up. (maps.org)
Alcohol4
  • D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. (bvsalud.org)
  • Here, we examined the impact of D- serine and D- cycloserine on this aversion-resistant alcohol intake (that persists despite adulteration with quinine ) and consumption of quinine -free alcohol. (bvsalud.org)
  • Systemic D- cycloserine also selectively reduced intake of quinine -adulterated alcohol, and D- cycloserine inhibited NAcore HA-NMDARs in vitro . (bvsalud.org)
  • Our results indicate that HA-NMDAR modulators can reduce aversion-resistant alcohol drinking , and support testing of D- serine and D- cycloserine as immediately accessible, FDA-approved drugs to treat AUDs. (bvsalud.org)
Enzymes1
Resistant1
  • Spores of ''B. clausii'' are resistant to many antibiotics including erythromycin, lincomycin, cephalosporins, and cycloserine. (kenyon.edu)
Depression1
  • Low-Dose d-Cycloserine for depression? (umn.edu)
Drug1
  • Rodelis Therapeutics recently acquired the drug and then proceeded to increase the price of 30 pills of cycloserine from $500 to $10,800. (moneytalksnews.com)
Works1
  • Cycloserine works by blocking the formation of these peptidoglycans. (drugbank.com)
Increase1
  • Cycloserine may increase the neurotoxic activities of Acetophenazine. (drugbank.com)
Site1
  • D- serine and D- cycloserine , the NMDAR activators at the glycine site, are of particular interest because they have been used in humans without serious adverse effects . (bvsalud.org)
Treatment1
  • A promising development in the treatment of anxiety disorders is the use of "cognitive-enhancing" medications like D-cycloserine (DCS) to improve conventional psychological therapies. (edu.au)
Ethionamide3
  • Efficacy and safety of kanamycin, ethionamide, PAS and cycloserine in multidrug-resistant pulmonary tuberculosis patients. (nih.gov)
  • ethionamide, cycloserine. (medscape.com)
  • Monitor Closely (1) ethionamide, cycloserine. (medscape.com)
Amikacin2
  • 2} In this child since all the first line drugs were resistant, the child was treated with amikacin, cycloserine, PAS, clofazamine and linezolid. (pediatriconcall.com)
  • On the 20th day of admission, therefore, rifampicin and ethambutol treatments of the girl were stopped, and anti-tuberculosis treatment was readjusted to high doses of isoniazid (15 mg/kg once daily), pyrazinamide (30 mg/kg/day), amikacin (15 mg/kg/day), levofloxacin (10 mg/kg twice daily), linezolid (10 mg/kg twice daily), cycloserine (15 mg/kg once daily) and clofazimine (5 mg/kg once daily) (8). (who.int)
Seromycin1
  • Cycloserine, chemically known as 4-amino-3-isoxazolidinone is a nootropic drug that is vended under the name Seromycin. (armodexperiment.com)
Fructose Agar3
  • Cycloserine Cefoxitin Fructose Agar with Lysozyme (CCFA-L) is an enriched, selective, and differential media used for the isolation and presumptive identification of Clostridium difficile , a recognized cause of pseudomembranous (antimicrobial agent-associated) colitis. (anaerobesystems.com)
  • Included Direct Culture onto Cycloserine Cefoxitin Fructose Agar and Enriched Culture Using Cycloserine Cefoxitin Mannitol Broth with Taurocholate and Lysozyme. (elsevier.com)
  • C. difficile toxin-positive stool specimens, in 1-mL aliquots, were shipped frozen to the Centers for Disease Control and Prevention (Atlanta, GA, USA) anaerobe laboratory for culturing by direct inoculation onto cycloserine cefoxitin fructose agar (CCFA) or ethanol shock, followed by CCFA inoculation. (cdc.gov)
NMDA6
  • Peripheral injections of D-cycloserine, a partial agonist of the glycine site on the NMDA receptor which crosses the blood-brain barrier, also doubles rabbits' learning rates. (northwestern.edu)
  • A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine. (ox.ac.uk)
  • Human participants were assigned to receive either 250 mg of the partial NMDA agonist d-cycloserine (n=20) or matching placebo capsules (n=27). (ox.ac.uk)
  • Facilitation of NMDA receptor function by NMDA receptor glycine-site agonists such as D-cycloserine and glycine is effective on the abnormal intracellular signaling, and emotional and cognitive deficits in mice treated with PCP repeatedly. (nih.gov)
  • NRX-101 combines D-cycloserine (DCS), an N-methyl-D-aspartate (NMDA) receptor antagonist, and lurasidone , a D 2 /5-HT 2a receptor antagonist. (empr.com)
  • Even though our understanding is quite limited, in schizophrenia and other neuropsychiatric disorders, significant efforts have been made to clinically enhance NMDA receptor activity though this co-agonist site, either directly by high-dose administration of glycine, D-serine or D-cycloserine (a partial agonist) or indirectly though inhibition of glycine transporters or D-amino acid oxidase. (ucdavis.edu)
Agar2
  • Tryptose Sulfite Cycloserine (TSC) Agar is a selective and differential medium used for the detection and counting of vegetative cells and spores of Clostridium perfringens by membrane filtration method (ISO 14189) in samples of water intended for human consumption or for inoculation in food samples. (generon-food-safety.com)
  • This is an impression smear photomicrograph of darkly-stained, rod-shaped, Clostridium difficile bacteria, grown on cycloserine-mannitol blood agar. (cdc.gov)
Cell-wall synthesis1
  • Cycloserine is a d-alanine analogue of isoxazolidone that was isolated initially from Streptococcus orchidaceus and has moderate activity in vitro against mycobacterial species, probably acting by inhibition of mycobacterial use of amino acids and inhibition of cell wall synthesis. (nih.gov)
Isoniazid3
  • Cycloserine was approved for use in the United States in 1964, but its use for most indications has been replaced by more modern antituberculosis agents except in instances of multidrug resistance or of intolerance to the more potent agents such as isoniazid, rifampin and pyrazinamide. (nih.gov)
  • Use of drugs such as isoniazid, cycloserine, penicillamine, hydralazine and levodopa which induces increased requirement for vitamin B 6 . (mims.com)
  • En standard tuberkulose behandling indledes med en kombination af fire antibiotika, rifampicin, isoniazid, pyrazinamid og ethambutol. (medicin.dk)
Mycobacteria1
  • Cycloserine clinical laboratory standard powder is available for both direct and indirect methods1 of determining the susceptibility of strains of mycobacteria. (nih.gov)
Agonist3
  • Previous research has demonstrated that systemic D-cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), enhances memory processes in different learning paradigms and attenuates mnemonic deficits produced by diverse pharmacological manipulations. (sigmaaldrich.com)
  • Here, we describe the cocrystal structures of the NR1 S1S2 ligand-binding core with the agonists glycine and D-serine (DS), the partial agonist D-cycloserine (DCS) and the antagonist 5,7-dichlorokynurenic acid (DCKA). (rcsb.org)
  • Different affinity to the NR3 subunits was observed for the partial agonist D-cycloserine and the antagonist 7-chloro-kynurenate, which could not displace [3H]-glycine from NR3A (paper III), but from NR3B (paper IV). (avhandlingar.se)
Toxicity1
  • The toxicity of cycloserine is closely related to excessive blood levels (above 30 μg/mL), as determined by high dosage or inadequate renal clearance. (nih.gov)
Broad-spectrum a1
  • Cycloserine, 3-isoxazolidinone, 4-amino -, (R)- is a broad-spectrum antibiotic that is produced by a strain of Streptomyces orchidaceus and has also been synthesized. (nih.gov)
250mg1
  • clopidogrel 75 mg tablet , clotrimazole 1% cream / oint , codeine lintus 15 mg / 5 ml syrup , containing urea i.p. + lactic acid + propylene glycol i.p. + liquid paraffin cream cream , cycloserine 250mg capsule , dapagliflozin 10 mg tablet , deflazacort 30 mg tablet , deflazacort 6 mg tablet , dexamethason 4 mg tab. (tendersindelhi.com)
Pharmacokinetics1
  • The pharmacokinetics of cycloserine were minimally affected by orange juice and antacids, whereas the high-fat meal delayed absorption. (medscape.com)
Gram-negative2
  • Cycloserine may be effective in the treatment of acute urinary tract infections caused by susceptible strains of gram-positive and gram-negative bacteria, especially Enterobacter spp. (nih.gov)
  • Cycloserine will inhibit gram-negative bacteria, while cefoxitin will inhibit both gram-positive and gram-negative organisms. (anaerobesystems.com)
Extinction of fear1
  • 9. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. (nih.gov)
Glycine site1
  • Further, the use of NMDAR glycine site agonists such as glycine, d -serine, or d -cycloserine in clinical trials has demonstrated some efficacy in ameliorating the negative symptoms and cognitive disabilities in schizophrenics ( Coyle and Tsai 2004a , 2004b ). (nih.gov)
Drugs2
  • Like all antituberculosis drugs, cycloserine should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent. (nih.gov)
  • One is the use of drugs like d-cycloserine to enhance extinction learning. (cogneurosociety.org)
Fear extinction1
  • D-cycloserine enhances generalization of fear extinction in children. (sigmaaldrich.com)
Efficacy1
  • In addition, a mixture of DAs enhanced antimicrobial efficacy of D-Cycloserine (DCS) up to 32% as compared with DCS treatment alone. (edu.au)
Inhibitor1
Dose4
  • To determine the effect of a high-fat meal, orange juice, and antacids on absorption of a single oral dose of cycloserine and to estimate its population pharmacokinetic parameters. (medscape.com)
  • Approximately 65 percent of a single dose of cycloserine can be recovered in the urine within 72 hours after oral administration. (nih.gov)
  • Cycloserine is reported to be associated with a low rate of serum aminotransferase elevations that are usually transient and asymptomatic and do not require dose modification. (nih.gov)
  • Dose-finding trial of d-cycloserine added to neuroleptics for negative symptoms in schizophrenia. (harvard.edu)
Molecular1
  • The molecular weight of cycloserine is 102.09, and it has an empirical formula of C3H6N2O2. (nih.gov)
Concentrations2
  • Therefore, it is important to clarify dosing conditions that may impair or promote achievement of adequate cycloserine plasma concentrations. (medscape.com)
  • The basic nutritive base consists of animal peptones and fructose and is supplemented with cefoxitin and cycloserine at concentrations that inhibit the growth of most normal fecal flora. (anaerobesystems.com)
Deficits2
  • D-cycloserine prevents relational memory deficits and suppression of long-term potentiation induced by scopolamine in the hippocampus. (sigmaaldrich.com)
  • D-Cycloserine ameliorates autism-like deficits by removing GluA2-containing AMPA receptors in a valproic acid-induced rat model. (ym.edu.tw)
Schizophrenia2
  • A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. (harvard.edu)
  • D-cycloserine added to clozapine for patients with schizophrenia. (harvard.edu)
Placebo-controlled1
  • Augmenting extinction learning with d-cycloserine reduces return of fear: A randomized, placebo-controlled fMRI study. (mpg.de)
Cognitive3
  • D-cycloserine augmentation of cognitive behavioral therapy for anxiety disorders: an update. (sigmaaldrich.com)
  • The Future of D-Cycloserine and Other Cognitive Modifiers in Obsessive-Compulsive and Related Disorders. (sigmaaldrich.com)
  • Presentations included an informative history of exposure therapy and related advances in anxiety disorder treatments, the use of D-Cycloserine for boosting the effects of an intervention, and the role of sudden gains and therapeutic alliance in cognitive behavioral therapy (CBT). (nih.gov)
Subunits1
  • When taking into account the use of knockout animals, it is important L-Cycloserine to acknowledge that deficiency in cytokine or receptor subunits may impact more than one particular cytokine as outlined in Figure 3B. (annumed.net)
Facilitate1
  • D-cycloserine (DCS) may facilitate treatment gains by increasing generalization of extinction learning, however, its effects have not been tested in children. (sigmaaldrich.com)
Severe1
  • Allergic reactions have been reported with cycloserine and, if severe, these may be accompanied by mild serum enzyme elevations. (nih.gov)
Effects3
  • Effects of food, acidic beverages, or antacids on the pharmaco-kinetics of cycloserine have not been evaluated in a crossover study. (medscape.com)
  • Effects of D-cycloserine on extinction: translation from preclinical to clinical work. (sigmaaldrich.com)
  • rarely, cycloserine causes more serious neurological side effects such as acute psychosis, seizures and coma. (nih.gov)