OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
CyclophilinsPeptidylprolyl IsomeraseCyclophilin AAmino Acid IsomerasesCyclosporineImmunophilinsAntigens, CD147Tacrolimus Binding ProteinsCyclosporinsStreptomyces antibioticusVirus Physiological PhenomenaCarrier ProteinsCalcineurinAmino Acid SequenceMolecular Sequence DataTacrolimusSequence Homology, Amino AcidRecombinant ProteinsHost-Pathogen InteractionsSequence AlignmentMolecular ChaperonesHeat-Shock ResponseCloning, MolecularImmunosuppressive Agents
Cyclophilins
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
Peptidylprolyl Isomerase
An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.
Cyclophilin A
A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.
Amino Acid Isomerases
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
Cyclosporine
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Antigens, CD147
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Tacrolimus Binding Proteins
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
Cyclosporins
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Streptomyces antibioticus
An actinomycete from which the antibiotic OLEANDOMYCIN is obtained.
Virus Physiological Phenomena
Biological properties, processes, and activities of VIRUSES.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Calcineurin
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tacrolimus
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Host-Pathogen Interactions
The interactions between a host and a pathogen, usually resulting in disease.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Molecular Chaperones
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
Heat-Shock Response
A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Two distinct regions of cyclophilin B are involved in the recognition of a functional receptor and of glycosaminoglycans on T lymphocytes. (1/501)

Cyclophilin B is a cyclosporin A-binding protein exhibiting peptidyl-prolyl cis/trans isomerase activity. We have previously shown that it interacts with two types of binding sites on T lymphocytes. The type I sites correspond to specific functional receptors and the type II sites to sulfated glycosaminoglycans. The interactions of cyclophilin B with type I and type II sites are reduced in the presence of cyclosporin A and of a synthetic peptide mimicking the N-terminal part of cyclophilin B, respectively, suggesting that the protein possesses two distinct binding regions. In this study, we intended to characterize the areas of cyclophilin B involved in the interactions with binding sites present on Jurkat cells. The use of cyclophilin B mutants modified in the N-terminal region demonstrated that the 3Lys-Lys-Lys5 and 14Tyr-Phe-Asp16 clusters are probably solely required for the interactions with the type II sites. We further engineered mutants of the conserved central core of cyclophilin B, which bears the catalytic and the cyclosporin A binding sites as an approach to localize the binding regions for the type I sites. The enzymatic activity of cyclophilin B was dramatically reduced after substitution of the Arg62 and Phe67 residues, whereas the cyclosporin A binding activity was destroyed by mutation of the Trp128 residue and strongly decreased after modification of the Phe67 residue. Only the substitution of the Trp128 residue reduced the binding of the resulting cyclophilin B mutant to type I binding sites. The catalytic site of cyclophilin B therefore did not seem to be essential for cellular binding and the cyclosporin A binding site appeared to be partially involved in the binding to type I sites.  (+info)

Evidence that cyclophilin-A protects cells against oxidative stress. (2/501)

Cyclophilin-A is the cytosolic isoform of a family of peptidylproline cis-trans-isomerases that bind cyclosporin A. This study investigates the role of cyclophilin-A in necrotic cell death, induced by 'chemical ischaemia' and by t-butylhydroperoxide. An 18-mer antisense phosphorothioate oligodeoxynucleotide was used to target a translated region of cyclophilin-A mRNA in rat neonatal cardiomyocytes. After a 24 h exposure to the oligonucleotide, the amount of cyclophilin-A in the cells was decreased by at least 93% as judged by immunological and enzymic criteria. For the enzyme assays, peptidyl proline cis-trans-isomerase activity was measured fluorimetrically in small (10 microl) volumes of cell extract. Immunoblots were developed with a polyclonal anti-cyclophilin-A antibody after sample isoelectric focusing and SDS/PAGE. Cyclophilin-A suppression had no effect on cyanide-plus-2-deoxyglucose-induced cell death. However, cyclophilin-A-suppressed cells were markedly more sensitive to t-butylhydroperoxide. Cyclosporin A conferred some resistance to the peroxide in both types of cell, but protection was greater in cyclophilin-A-suppressed cells, where cyclosporin A increased the survival time 2-fold. It is concluded that two cyclophilin isoforms are involved, in quite different ways, in peroxide-induced cell death. Cyclophilin-A has a protective role. Another isoform, possibly mitochondrial cyclophilin-D, has a deleterious role, such that blockade by cyclosporin A leads to protection.  (+info)

Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains. (3/501)

A role for DnaK, the major E. coli Hsp70, in chaperoning de novo protein folding has remained elusive. Here we show that under nonstress conditions DnaK transiently associates with a wide variety of nascent and newly synthesized polypeptides, with a preference for chains larger than 30 kDa. Deletion of the nonessential gene encoding trigger factor, a ribosome-associated chaperone, results in a doubling of the fraction of nascent polypeptides interacting with DnaK. Combined deletion of the trigger factor and DnaK genes is lethal under normal growth conditions. These findings indicate important, partially overlapping functions of DnaK and trigger factor in de novo protein folding and explain why the loss of either chaperone can be tolerated by E. coli.  (+info)

The mitochondrial permeability transition pore and its role in cell death. (4/501)

This article reviews the involvement of the mitochondrial permeability transition pore in necrotic and apoptotic cell death. The pore is formed from a complex of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase and cyclophilin-D (CyP-D) at contact sites between the mitochondrial outer and inner membranes. In vitro, under pseudopathological conditions of oxidative stress, relatively high Ca2+ and low ATP, the complex flickers into an open-pore state allowing free diffusion of low-Mr solutes across the inner membrane. These conditions correspond to those that unfold during tissue ischaemia and reperfusion, suggesting that pore opening may be an important factor in the pathogenesis of necrotic cell death following ischaemia/reperfusion. Evidence that the pore does open during ischaemia/reperfusion is discussed. There are also strong indications that the VDAC-adenine nucleotide translocase-CyP-D complex can recruit a number of other proteins, including Bax, and that the complex is utilized in some capacity during apoptosis. The apoptotic pathway is amplified by the release of apoptogenic proteins from the mitochondrial intermembrane space, including cytochrome c, apoptosis-inducing factor and some procaspases. Current evidence that the pore complex is involved in outer-membrane rupture and release of these proteins during programmed cell death is reviewed, along with indications that transient pore opening may provoke 'accidental' apoptosis.  (+info)

Import and processing of heart mitochondrial cyclophilin D. (5/501)

Cyclophilins are a family of cyclosporin-A-binding proteins which catalyse rotation about prolyl peptide bonds. A mitochondrial isoform in mammalian cells, cyclophilin D, is a component of the permeability transition pore that is formed by the adenine nucleotide translocase and the voltage-dependent anion channel at contact sites between the inner and outer membrane. This study investigated the submitochondrial location of cyclophilin D by following the fate of radiolabelled protein following import. Precursor [(35)S]cyclophilin D was expressed in vitro from a PCR-generated cDNA. The precursor was imported by rat heart mitochondria and processed in a single step to a 21-kDa protein that was identical (SDS/PAGE) to an in vitro expressed mature protein and a cyclophilin D purified from rat heart mitochondria. No further modification of the mature protein could be demonstrated. Fractionation of mitochondria following import established that cyclophilin D locates only to the matrix. It is concluded that cyclophilin D binding to the permeability transition pore must occur at the inner face of the mitochondrial inner membrane.  (+info)

Cyclophilin B binding to platelets supports calcium-dependent adhesion to collagen. (6/501)

We have recently reported that cyclophilin B (CyPB), a secreted cyclosporine-binding protein, could bind to T lymphocytes through interactions with two types of binding sites. The first ones, referred to as type I, involve interactions with the conserved domain of CyPB and promote the endocytosis of surface-bound ligand, while the second type of binding sites, termed type II, are represented by glycosaminoglycans (GAG). Here, we further investigated the interactions of CyPB with blood cell populations. In addition to lymphocytes, CyPB was found to interact mainly with platelets. The binding is specific, with a dissociation constant (kd) of 9 +/- 3 nmol/L and the number of sites estimated at 960 +/- 60 per cell. Platelet glycosaminoglycans are not required for the interactions, but the binding is dramatically reduced by active cyclosporine derivatives. We then analyzed the biologic effects of CyPB and found a significant increase in platelet adhesion to collagen. Concurrently, CyPB initiates a transmembranous influx of Ca(2+) and induces the phosphorylation of the P-20 light chains of myosin. Taken together, the present results demonstrate for the first time that extracellular CyPB specifically interacts with platelets through a functional receptor related to the lymphocyte type I binding sites and might act by regulating the activity of a receptor-operated membrane Ca(2+) channel.  (+info)

A cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor-specific CTLs. (7/501)

We have studied Ags recognized by HLA class I-restricted CTLs established from tumor site to better understand the molecular basis of tumor immunology. HLA-A24-restricted and tumor-specific CTLs established from T cells infiltrating into lung adenocarcinoma recognized the two antigenic peptides encoded by a cyclophilin B gene, a family of genes for cyclophilins involved in T cell activation. These two cyclophilin B peptides at positions 84-92 and 91-99 induced HLA-A24-restricted CTL activity against tumor cells in PBMCs of leukemia patients, but not in epithelial cancer patients or in healthy donors. In contrast, the modified peptides at position 2 from phenylalanine to tyrosine, which had more than 10 times higher binding affinities to HLA-A24 molecules, could induce HLA-A24-restricted CTL activity against tumor cells in PBMCs from leukemia patients, epithelial cancer patients, or healthy donors. PHA-activated normal T cells were resistant to lysis by the CTL line or by these peptide-induced CTLs. These results indicate that a cyclophilin B gene encodes antigenic epitopes recognized by CTLs at the tumor site, although T cells in peripheral blood (except for those from leukemia patients) are immunologically tolerant to the cyclophilin B. These peptides might be applicable for use in specific immunotherapy of leukemia patients or that of epithelial cancer patients.  (+info)

Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis. (8/501)

Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. ANT-1 expression led to all features of apoptosis, such as phenotypic alterations, collapse of the mitochondrial membrane potential, cytochrome c release, caspase activation, and DNA degradation. Both point mutations that impair ANT-1 in its known activity to transport ADP and ATP as well as the NH(2)-terminal half of the protein could still induce apoptosis. Interestingly, ANT-2, a highly homologous protein could not lead to cell death, demonstrating the specificity of the signal for apoptosis induction. In contrast to Bax, a proapoptotic Bcl-2 gene, ANT-1 was unable to elicit a form of cell death in yeast. This and the observed repression of apoptosis by the ANT-1-interacting protein cyclophilin D suggest that the suicidal effect of ANT-1 is mediated by specific protein-protein interactions within the permeability transition pore.  (+info)

Rat CYPB(Cyclophilin B) ELISA Kit - Rat CYPB(Cyclophilin B) ELISA Kit Exporter, Importer, Manufacturer, Distributor, Supplier,...
SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Rat CYPB(Cyclophilin B) ELISA Kit based in Delhi, India
https://www.srgroupchemical.com/rat-cypb-cyclophilin-b-elisa-kit-4473194.html
Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy<...
TY - JOUR. T1 - Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy. AU - Williams, Paul D.. AU - Owens, Charles R.. AU - Dziegielewski, Jaroslaw. AU - Moskaluk, Christopher A.. AU - Read, Paul W.. AU - Larner, James M.. AU - Story, Michael D.. AU - Brock, William A.. AU - Amundson, Sally A.. AU - Lee, Jae K.. AU - Theodorescu, Dan. N1 - Funding Information: Abbreviations: PPIB, cyclophilin B; COXEN, Coexpression Extrapolation; GEM, gene expression model Address all correspondence to: Dan Theodorescu, MD, PhD, Departments of Surgery and Pharmacology and Comprehensive Cancer Center, University of Colorado, 13001 E 17th Pl MS #F-434, Aurora, CO 80045. E-mail: [email protected] 1This work was supported in part by National Institutes of Health grants DK069264 to P.D.W., CA06294 to M.D.S. and W.A.B., HL081690 to J.K.L., CA075115 to D.T., and U19AI067773 and US Department of Energy DE-FG02-07ER46336 to S.A.A. 2This article refers to ...
https://utsouthwestern.pure.elsevier.com/en/publications/cyclophilin-b-expression-is-associated-with-in-vitro-radioresista
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis - PubMedEvaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis - PubMed
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet …
https://pubmed.ncbi.nlm.nih.gov/31717385/
Viruses | Free Full-Text | Cyclophilin Inhibitors as a Novel HCV Therapy | NotesViruses | Free Full-Text | Cyclophilin Inhibitors as a Novel HCV Therapy | Notes
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA probably interacts directly with nonstructural protein 5A to exert its effect, through its peptidyl-prolyl isomerase activity, on maintaining the proper structure and function of the HCV replicase. The major proline substrates are located in domain II of NS5A, centered around a
http://www.mdpi.com/1999-4915/2/8/1621/notes
The influence of a green roof drainage layer on retention capacity and leakage qualityThe influence of a green roof drainage layer on retention capacity and leakage quality
The aim of the research was to determine the influence of the substrate and different drainage materials on retention capacity and runoff water quality from three green roof containers. Phosphates were chosen as the water quality indicator based on their potential adverse impact on water quality in …
https://pubmed.ncbi.nlm.nih.gov/30065141/
British Library EThOS: Role of cyclophilins and heat shock proteins in myocardial ischaemia/reperfusion injuryBritish Library EThOS: Role of cyclophilins and heat shock proteins in myocardial ischaemia/reperfusion injury
Restoration of blood flow after myocardial infarction (MI), surgery or fibrinolytic therapy is necessary, but can lead to cardiomyocyte dysfunction within a generalised condition commonly known as reperfusion injury. The role of cyclophilins, heat shock proteins (HSP), and the mitochondrial chaperone complex (MCC), was studied in this pathological condition. In vitro and in vivo models were used to replicate conditions of ischaemia/reperfusion (IR) injury. H9c2 and COS-7 cell lines were employed in nitric oxide (NO) donor and transfection applications. Experimental protocols were used to determine mitochondrial membrane potential (MMP), mitochondrial morphology, protein expression, enzyme activity and cell damage in these models. No difference was observed in activity or expression in cyclophilin or expression of the MCC in any of the models. It was noted that in the in vitro model, cell death was predominantly necrotic with only a minority of cells undergoing apoptosis, and as the degree of ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409642
Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention<...
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
https://mayoclinic.pure.elsevier.com/en/publications/novel-approach-to-inhibit-asthma-mediated-lung-inflammation-using
siGENOME Cyclophilin B Control siRNA | Dharmacon
A validated positive silencing control targeting the Cyclophilin B (PPIB) gene in human, mouse, or rat cell lines. Useful for determination of optimal RNAi experimental conditions
http://dharmacon.gelifesciences.com/rnai/controls/sirna/sigenome/sigenome-cyclophilin-b-control-sirna/
Involvement of Cyclophilin D and Calcium in Isoflurane-induced PreconditioningInvolvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning
The mitochondrial permeability transition pore (PTP) has been established as an important mediator of ischemia-reperfusion-induced cell death. The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. Therefore, the authors hypothesized that isoflurane, by inhibiting the re...
https://insights.ovid.com/anesthesiology/anet/2015/12/000/involvement-cyclophilin-calcium-isoflurane-induced/28/00000542
Cyclophilin B - bs-6609R | acris-antibodies.com
Cyclophilin B, 0.1 ml. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
https://www.acris-antibodies.com/antibodies/primary-antibodies/cyclophilin-b-bs-6609r.htm
European StudentEuropean Student
Research and training opportunities are available in a laboratory of the National Research Council of Italy for a postgraduate or postdoctoral student in the field of molecular parasitology. The laboratory is about to be relocated near Rome, in a multidisciplinary research complex comprising a European facility for the study of mouse mutants and four research groups of the EMBL. The proposed project is based on the study of cyclophilins (cyclosporin binding proteins) of the human parasites belonging to the genus Schistosoma. Molecular cloning and biochemical studies of schistosome cyclophilins are already under way in the host laboratory. An interest in cyclophilins is due to their likely role in mediating the antiparasitic effects of cyclosporin A and its derivatives. Supervision and research facilities will be provided to students who have been successful in applying to the Training and Mobility of Researchers Programme of the European Community (see the call for proposals under ...
http://www.bio.net/bionet/mm/immuno/1995-November/005904.html
Retraction: Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D...Retraction: Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D...
Retraction of: J. Cell Sci. 123, 4117-4127. This article has been retracted at the request of the corresponding author, John G. Pastorino.. This notice updates and replaces a recent Expression of Concern, published on 15 February 2016.. Journal of Cell Science was alerted to potential blot duplication and reuse in the following five papers published in Journal of Cell Science by John G. Pastorino:. Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria Nataly Shulga, Robin Wilson-Smith and John G. Pastorino J. Cell. Sci. (2010) 123, 894-902. Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3 Nataly Shulga and John G. Pastorino J. Cell. Sci. (2010) 123, 4117-4127. GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis Nataly Shulga and John G. Pastorino J. Cell. Sci. (2012) 125, 2995-3003. Sirtuin-3 modulates Bak- and Bax-dependent ...
http://jcs.biologists.org/content/129/13/2685
An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C - DebiopharmAn evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C - Debiopharm
Raf Crabbé, Grégoire Vuagniaux, Jean-Maurice Dumont, Valérie Nicolas-Métral, Judith Marfut / Laura Novaroli Export Opinion on Investigational Drugs
https://www.debiopharm.com/drug-development/publications/an-evaluation-of-the-cyclophilin-inhibitor-debio-025-and-its-potential-as-a-treatment-for-chronic-hepatitis-c/
Anti-Cyclophilin B AntibodyAnti-Cyclophilin B Antibody
Polyclonal antibody for Cyclophilin B/PPIB detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Cyclophilin B/PPIB information: Molecular Weight: 23743 MW; Subcellular Localization: Endoplasmic reticulum lumen. Me
https://www.bosterbio.com/anti-cyclophilin-b-antibody-pa2151.html
Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the...Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the...
Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is
https://research.pasteur.fr/en/publication/characterization-of-the-anti-hepatitis-c-virus-activity-of-new-non-peptidic-small-molecule-cyclophilin-inhibitors-with-a-potential-for-broad-anti-activity/
Cyclophilin D Enzyme Human Recombinant | CypD Protein | ProSpecCyclophilin D Enzyme Human Recombinant | CypD Protein | ProSpec
Cyclophilin-D Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 178 aa having a molecular mass of 18.9kDa.
https://www.prospecbio.com/human_cyclophilin_d
Structure Cluster - 3RCL: Human Cyclophilin D Complexed with a Fragment 3D Similarity Report PageStructure Cluster - 3RCL: Human Cyclophilin D Complexed with a Fragment 3D Similarity Report Page
3RCL: Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
https://www3.rcsb.org/pdb/explore/structureCluster.do?structureId=3RCL
Current implications of cyclophilins in human cancers - CORECurrent implications of cyclophilins in human cancers - CORE
2004). Patz EF Jr: Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. Lung Cancer ...
https://core.ac.uk/display/8436155
Cyclophilin | ProSpecCyclophilin | ProSpec
ProSpecs Cyclophilins include: Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant
https://www.prospecbio.com/cyclophilin
Functional and structural characterization of spliceosomal cyclophilins - Tara DavisFunctional and structural characterization of spliceosomal cyclophilins - Tara Davis
The spliceosome is a complex and dynamic collection of RNA and proteins that removes introns from precursor mRNA transcripts. Alterations in the splicing machin...
http://grantome.com/grant/NIH/R00-GM094293-04
5ta4.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 5ta4.1. Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A
https://swissmodel.expasy.org/templates/5ta4.1
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP AntibodyAnti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_A-K/CyCAP?sitex=10020:22372:US&PEBCL1=XycBPS5ep01D5HH439enKFKVt4&PEBCL1_pses=ZG278E2D79FD678EB2D804BB908D210D3123EBB45E18C2294CEDB12ED10DBAA4BDB1C8BBE730EDBF31523584EF681CEF3707077E50534BDEC8
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP AntibodyAnti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_A-K/CyCAP?sitex=10020:22372:US&PEBCL1=VKO798Kv69kykYjwpMZykmIsiK&PEBCL1_pses=ZGDAC7694A7FC1421AFDADF1AABE5E4D675AF996C1910AA034213EEAFB56436BE9526E61AF77E02EDFF748384C2263A714847716176665CFF4
Multiple Cancers | Debio | Clinical Trial | CTCAMultiple Cancers | Debio | Clinical Trial | CTCA
Debio: 1347-201: A phase 2 basket study of the oral selective pan-FGFR inhibitor Debio 1347 in subjects with solid tumors harboring a fusion of FGFR1, FGFR2 or FGFR3 The FUZE Clinical Trial
https://www.cancercenter.com/clinical-trials/multiple-cancers-debio
Functional Analyzers | Functional & Rheological | KPM AnalyticsFunctional Analyzers | Functional & Rheological | KPM Analytics
Functional analyzers characterize the key properties of flour and grains to help manufacturers produce consistently high-quality baked goods and snack foods. Widely used in the wheat breeding, milling, and baking industries, our unique analyzers measure starch damage, sprout damage, solvent retention capacity, and impurities in flour and grain, providing multiple indicators for quality control.
https://www.kpmanalytics.com/product-sub-categories/functional-analyzers
Exufiber gelling fibre dressing for treating highly exuding and cavity wounds | MölnlyckeExufiber gelling fibre dressing for treating highly exuding and cavity wounds | Mölnlycke
Mölnlycke Exufiber gelling fibre dressing with Hydrolock technology and advanced fluid retention capacity for treating highly exuding and cavity wounds 
https://www.molnlycke.com/products-solutions/exufiber/
Improved Whiteness, finer crumb structureImproved Whiteness, finer crumb structure
SEBake PF can be used to strengthen the dough, improve dough mixing tolerance & machinability, as well as to enhance the gas retention capacity of the dough.. ...
https://www.enzymeinnovation.com/baking-milling/improved-whiteness-finer-crumb-structure/
siGLO Lamin A/C siRNA (Human/Mouse/Rat)siGLO Lamin A/C siRNA (Human/Mouse/Rat)
A stable, fluorescent positive control suitable for RNAi experiments in human, mouse, or rat cells Silences the Cyclophilin B gene and is labeled with DY-547
https://horizondiscovery.com/en/products/gene-modulation/transfection-and-ancillary-reagents/PIFs/siGLO-Lamin-A-C-siRNA-Human-Mouse-Rat
PPIF Antibody (CF809070)PPIF Antibody (CF809070)
OriGene Anti-PPIF Monoclonal (OTI1G8), TrueMAB™, Catalog # CF809070. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human samples. Supplied as 100 µg purified antibody.
https://www.thermofisher.com/antibody/product/PPIF-Antibody-clone-OTI1G8-Monoclonal/CF809070
Supplementary MaterialsAdditional document 1: Shape S1 - Inhibition of CypD with the pharmacologic inhibitorSupplementary MaterialsAdditional document 1: Shape S1 - Inhibition of CypD with the pharmacologic inhibitor
Supplementary MaterialsAdditional document 1: Shape S1. Shape S2. Pluripotency characterization of DOX-hLIF-2i piPSCs, linked to Fig.?2. (A) Immunofluorescence assay of SSEA-4, TRA-1-60, TRA-1-80. Size pub, 20?m. (B) EBs of DOX-hLIF-2i piPSCs acquired at day time 6 of differentiation. Size pub, 100?m. (C) Fluorescence recognition of OCT4-tdTomato in DOX-hLIF-2i piPSCs. Size bar of the very best shape, 100?m. Size bar of underneath shape, 50?m. (D) Cell morphology and AP staining of DOX-hLIF-2i piPSCs with DOX and without DOX. Size pub, 200?m. (E) RT-PCR evaluation of endogenous manifestation of OCT4, SOX2, KLF4 and exogenous and cMYC OKSM. EF1A was utilized as inner control. 1#, 2# represent two lines of DOX-hLIF-2i piPSCs. Shape S3. The result of IRF-1 overexpression on DOX-hLIF-2i piPSCS morphology, linked to Fig.?3. (A) DAPI staining of IRF-1-overexpressing and adverse control piPSCs in Fig.?3a. Size bars from remaining to correct, 200?m, 50?m. (B) RT-PCR evaluation of endogenous expression ...
http://pharosevent.com/%EF%BB%BFsupplementary-materialsadditional-document-1-shape-s1/
PLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl IsomerasesPLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
http://journals.plos.org/plosbiology/article/authors?id=10.1371/journal.pbio.1000439&imageURI=info:doi/10.1371/journal.pbio.1000439.g006
PLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl IsomerasesPLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
http://journals.plos.org/plosbiology/article/comments?id=10.1371/journal.pbio.1000439&imageURI=info:doi/10.1371/journal.pbio.1000439.g004
Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death...Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death...
The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies. While post-translational modifications of CypD have been shown to modulate pore opening, specific phosphorylation sites of CypD have not yet been identified. We hypothesized here that phosphorylation of CypD on a serine residue controls mPTP opening and subsequent cell death at reperfusion. We combined in silico analysis with in vitro and genetic manipulations to determine potential CypD phosphorylation sites and their effect on mitochondrial function and cell death. Importantly, we developed an in vivo intramyocardial adenoviral strategy to assess the effect of the CypD phosphorylation event on infarct size. Our results show that although CypD can potentially be phosphorylated at
https://www.nature.com/articles/s41419-020-02864-5
Characterization of the redox state of human cyclophilin-D and its interactions with peroxiredoxin 5 | DIAL.pr - BOREALCharacterization of the redox state of human cyclophilin-D and its interactions with peroxiredoxin 5 | DIAL.pr - BOREAL
eng] Cyclophilin-D (CyP-D) is a peptidyl prolyl cis/trans isomerase located in the mitochondrial matrix of mammalian cells. The subcellular localization of the protein is determined by the presence of a mitochondrial targeting presequence. In the first part of this work, we characterized human CyP-D presequence allowing the protein translocation into mitochondria. We showed that the 16 first amino acid of the presequence are necessary and sufficient to form a functional presequence and to address hCyP-D into mitochondria. One of the main physiological roles of CyP-D is to activate the mitochondrial permeability transition pore (mPTP) opening. The mPTP is a protein complex formed during oxidative stress and leading to cell necrosis. Thus, CyP-D may be considered as a necrosis inductor. Nevertheless, several studies have also shown that CyP-D exhibits a protective role toward apoptosis induced by oxidative stress. However, the mechanism implicated in the cellular protection conferred by CyP-D is ...
https://dial.uclouvain.be/pr/boreal/object/boreal:20884
Dynamin-2-Dependent Targeting of Mannheimia haemolytica Leukotoxin to Mitochondrial Cyclophilin D in Bovine Lymphoblastoid...Dynamin-2-Dependent Targeting of Mannheimia haemolytica Leukotoxin to Mitochondrial Cyclophilin D in Bovine Lymphoblastoid...
Numerous mechanisms have been suggested for how bacterial toxins kill susceptible mammalian cells. Several recent studies demonstrated the importance of mitochondrial targeting of toxins produced by H. pylori, C. difficile, and S. aureus to mitochondria (56). In these cases toxin-mediated cell death was caspase independent and did not result in typical PTPs in the MOM (14, 18).. Previously, we reported that M. haemolytica LKT induces apoptosis of BL-3 cells in a caspase-9-dependent manner and that in mitochondria isolated from LKT-intoxicated BL-3 cells there was gross damage to the MOM (4). Based on these observations, we hypothesized that LKT is transported into the cell and binds directly to mitochondria. In the present study, we first demonstrated that full-length LKT protein could be identified in purified mitochondrial lysates from LKT-treated BL-3 cells (Fig. 1A). Transfection of anti-LKT antibodies into BL-3 cells prevented binding of LKT to mitochondria. Confocal microscopy and flow ...
https://iai.asm.org/content/76/11/5357
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in...
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinsons disease Academic Article ...
http://vivo.med.cornell.edu/display/pubid84863229879
Ppif - Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor - Mus musculus (Mouse) - Ppif gene & proteinPpif - Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor - Mus musculus (Mouse) - Ppif gene & protein
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
https://www.uniprot.org/uniprot/Q99KR7
Peptidylprolyl Isomerase B (Cyclophilin B) (PPIB) (AA 26-216) Peptide</span...Peptidylprolyl Isomerase B (Cyclophilin B) (PPIB) (AA 26-216) Peptide</span...
Recombinant Peptidylprolyl Isomerase B (Cyclophilin B) (PPIB) Peptide. Species: Human. Source: Escherichia coli (E. coli). Order product ABIN934947.
http://www.antibodies-online.com/peptide/934947/Peptidylprolyl+Isomerase+B+Cyclophilin+B+PPIB+AA+26-216+peptide/
Patente US8021998 - Absorbent structure with superabsorbent material - Google PatentesPatente US8021998 - Absorbent structure with superabsorbent material - Google Patentes
An absorbent structure made at least in part from a superabsorbent material having a retention capacity (CRC) as determined by a Centrifuge Retention Capacity Test of at least about 25 g/g and a free swell gel bed permeability (GBP) as determined by a Free Swell Gel Bed Permeability Test of at least 575 10−9 cm2. In another embodiment, the absorbent structure is made at least in part from a superabsorbent material having a retention capacity (CRC) as determined by a Centrifuge Retention Capacity Test of at least about 25 g/g, an absorbency under load (AUL) at 0.9 psi as determined by an Absorbency Under Load Test of at least 18 and a free swell gel bed permeability (GBP) as determined by a Free Swell Gel Bed Permeability Test of at least about 350 10−9 cm2.
http://www.google.es/patents/US8021998?dq=flatulence
Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motilityCyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility
article{203b97eb-96fd-4fd8-a31f-dd57ba747ae5, abstract = {,p,Mitochondria control bioenergetics and cell fate decisions, but how they influence nuclear gene expression is understood poorly. Here, we show that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator, results in increased cell proliferation and enhanced cell migration and invasion. These responses are associated with extensive transcriptional changes, modulation of a chemokine/chemokine receptor gene signature, and activation of the pleiotropic inflammatory mediator, STAT3. In the absence of CypD, active STAT3 enhances cell proliferation via accelerated entry into S-phase and stimulates autocrine/paracrine cell motility through Cxcl12-Cxcr4-directed chemotaxis. Therefore, CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells. This pathway may contribute to malignant traits under conditions of CypD ...
https://lup.lub.lu.se/search/publication/203b97eb-96fd-4fd8-a31f-dd57ba747ae5
Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins. |...Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins. |...
The mechanism by which cyclosporin A (CsA) inhibits vaccinia virus (VV) replication is still unclear. The present study addresses the question of whether CsA-binding proteins named cyclophilins (Cyps) are involved in the anti-VV activity of CsA. Six CsA analogues were analysed, and their affinity for Cyps in VV-infected BSC-40 cells and their potency as inhibitors of VV replication were evaluated. It was demonstrated that analogues with strong Cyp-binding activity, such as CsC, CsG and [MeAla6]CsA, also exhibit a strong antiviral effect. In contrast, drugs with low ([MeBm2t1]CsA and CsH) or no ([MeLeu11]CsA) affinity for Cyps show poor or no antiviral activity. The data obtained suggest a correlation between the ability of CsA to block VV replication and Cyp binding activity, and indicate the involvement of Cyps in the VV replicative cycle. They also suggest that the anti-VV action of CsA may occur by a pathway distinct from that involved in the immunosuppressive effect of the drug.
https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-79-2-339
The Role of Cyclophilin D in Mitochondrial Mediated Drug Toxicity by Amanda LoGuidiceThe Role of Cyclophilin D in Mitochondrial Mediated Drug Toxicity by Amanda LoGuidice
Drug-induced mitochondrial dysfunction has been implicated in many types of organ toxicity, including liver and intestine. The induction of the mitochondrial permeability transition (mPT) has been seen as a mechanism of this toxicity. The mitochondrial matrix protein cyclophilin D (CypD) is a key regulator of the mPT, lending itself as a potential target for therapeutic intervention. The overall aim of this research project is to explore the mPT as a potential mediator of drug-induced mitochondrial toxicity in intestine and liver. Small intestinal ulceration is a frequent and serious adverse effect associated with the use of non-steroidal anti-inflammatory drugs. Mitochondria have been implicated in ulcer development. We have shown that inhibition of the mPT pore by pharmacologic blockade of CypD resulted in significant protection from diclofenac injury in cultured enterocytes and a 70% reduction in intestinal ulcers in mice. Furthermore, Ppif-/- (the gene encoding CypD) mice show 80% ulcer reduction
http://opencommons.uconn.edu/dissertations/AAI3485225/
Peptidyl-prolyl cis-trans isomerase-like 4Peptidyl-prolyl cis-trans isomerase-like 4
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008 ...
https://pharos.nih.gov/idg/targets/Q8WUA2
Immunophilins and the nervous system. | PMID 7584950 | Nat Med January 01, 1995 | PubRank
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88 The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart. J Physiol (1997) 2.01 Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrob Agents Chemother (2008) 1.46 Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. Am J Pathol (1997) 1.17 Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein. Biophys J (1995) 1.10 A role for FKBP52 in Tau protein function. Proc Natl Acad Sci U S A (2010) 1.07 FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res (2011) 0.99 From nature to the laboratory and into the clinic. Bioorg Med Chem (2008) 0.95 ...
https://pubrank.carbocation.com/pmid/7584950
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte...Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte...
Astrocytes extend highly branched processes that form functionally isolated microdomains, facilitating local homeostasis by redistributing ions, removing neurotransmitters, and releasing factors to influence blood flow and neuronal activity. Microdomains exhibit spontaneous increases in calcium (Ca2+), but the mechanisms and functional significance of this localized signaling are unknown. By developing conditional, membrane-anchored GCaMP3 mice, we found that microdomain activity that occurs in the absence of inositol triphosphate (IP3)-dependent release from endoplasmic reticulum arises through Ca2+ efflux from mitochondria during brief openings of the mitochondrial permeability transition pore. These microdomain Ca2+ transients were facilitated by the production of reactive oxygen species during oxidative phosphorylation and were enhanced by expression of a mutant form of superoxide dismutase 1 (SOD1 G93A) that causes astrocyte dysfunction and neurodegeneration in amyotrophic lateral sclerosis ...
http://bergleslab.com/index.php/2017/02/08/agarwal2017/
Activation of the Mitochondrial Permeability Transition Pore Modulates Ca2+ Responses to Physiological Stimuli in Adult...
The participation of mitochondria in cellular and neuronal Ca2+ homeostatic networks is now well accepted. Yet, critical tests of specific mitochondrial pathways in neuronal Ca2+ responses have been hampered because the identity of mitochondrial proteins that must be integrated within this dynamic system remain uncertain. One putative pathway for Ca2+ efflux from mitochondria exists through the formation of the permeability transition pore (PTP) that is often associated with cellular and neuronal death. Here, we have evaluated neuronal Ca2+ dynamics and the PTP in single adult neurons in wild-type mice and those missing cyclophilin D (CyPD), a key regulator of the PTP. Using high-resolution time-lapse imaging, we demonstrate that PTP opening only follows simultaneous activation with two physiological stimuli that generate critical threshold levels of cytosolic and mitochondrial Ca2+. Our results are the first to demonstrate CyPD-dependent PTP opening in normal neuronal Ca2+ homeostatic ...
https://www.research.unipd.it/handle/11577/140265
Calcium modulating ligand - WikipediaCalcium modulating ligand - Wikipedia
Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI. The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. CAMLG has been shown to interact with TNFRSF13B. GRCh38: Ensembl release 89: ENSG00000164615 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021501 - Ensembl, May 2017 Human PubMed Reference:. Mouse ...
https://en.wikipedia.org/wiki/Calcium_modulating_ligand
Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells - Semantic ScholarDebio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells - Semantic Scholar
To characterize the cellular action mechanism of Debio 0507, we compared the major DNA adducts formed by Debio 0507- and oxaliplatin-treated HCT116 human colon carcinoma cells by a combination of inductively coupled plasma mass spectrometry (ICP-MS) and ultraperformance liquid chromatography mass spectrometry (UPLC-MS/MS). HCT116 cells were treated with IC50 doses of Debio 0507 or oxaliplatin for 3 days. Total cellular Pt-DNA adducts were determined by ICP-MS. The DNA was digested, and the major Pt-DNA adducts formed by both drugs were characterized by UPLC/MS/MS essentially as described previously for cisplatin (Baskerville-Abraham et al. in Chem Res Toxicol 22:905-912, 2009). The Pt level/deoxynucleotide was 7.4/104 for DNA from Debio 0507-treated cells and 5.5/104 for oxaliplatin-treated cells following a 3-day treatment at the IC50 for each drug. UPLC-MS/MS in the positive ion mode confirmed the major Pt-DNA adducts formed by both drugs were dach-Pt-d(GpG) (904.2 m/z → 610 m/z and 904.2 m/z →
https://www.semanticscholar.org/paper/Debio-0507-primarily-forms-diaminocyclohexane-Pt-d-King-Ramachandran/d7f86ac880f505ff8b02bc6acef78740b7736188
Recombinant Human Cyclophilin E protein (His tag) (ab206449) | AbcamRecombinant Human Cyclophilin E protein (His tag) (ab206449) | Abcam
Recombinant Human Cyclophilin E protein (His tag) is an Escherichia coli Full length protein 2 to 301 aa range, | 95% purity, | 1.000 Eu/µg endotoxin level and validated in SDS-PAGE, MS.
https://www.abcam.com/recombinant-human-cyclophilin-e-protein-his-tag-ab206449.html
Recombinant human Cyclophilin 40 protein (ab78815) ReferencesRecombinant human Cyclophilin 40 protein (ab78815) References
References for Abcams Recombinant human Cyclophilin 40 protein (ab78815). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-cyclophilin-40-protein-ab78815-references.html
Faculty- Roberta Gottlieb
Rescue and Role of Complex I in Myocardial Ischemic Injury: Members of the Bcl-2 family function at the mitochondrial outer membrane to regulate programmed cell death, or apoptosis. Bax and Bak are multi-domain pro-apoptotic members of the family, but their activity is directly or indirectly regulated by proteins of the BH3-only subfamily (Bcl-2 relatives that only share homology in domain 3). We are interested in Bid, a BH3-only protein that is proteolytically activated during ischemia/reperfusion and targets the mitochondria to initiate apoptosis. Mitochondria can promote necrotic cell death through a second pathway involving a mysterious entity known as the Mitochondrial Permeability Transition Pore, which includes cyclophilin D and other components that are the subject of intense investigation. We hypothesize that the electron transfer Complex I may be a part of the pore and may be regulated by Complex I. We have developed a cell-permeable therapeutic protein that can protect the heart ...
http://www.bio.sdsu.edu/faculty/gottlieb.html
CIAFEL - Bolsas de InvestigaçãoCIAFEL - Bolsas de Investigação
This project will analyze the effects of life-long physical activity on brain function in Alzheimer disease (AD) and aging with special reference to mitochondrial-mediating mechanisms. Behavioral tests, mitochondrial bioenergetics endpoints (oxygen consumption, transmembrane potential) and calcium movements will be performed. Markers of oxidative damage, mitochondrial dynamics, apoptosis and antioxidants, including Bax/Bcl2, SIRT3, p66Shc, MnSOD, aconitase, carbonyls, PGC-1a, Mfn, Drp 1, Fis-1, caspase 3/9 activities, and the mitochondrial permeability transition pore regulators F(1)F(0) ATP-synthase c subunit, ANT and cyclophilin D will be measured. With this project funded by FCT (PTDC/DTP/DES/1246/2012), important contributions to understand the mitochondrial mechanisms associated with the role of exercise to mitigate age- and AD-related brain dysfunction will be provided. Depending on the data obtained, it may be suggested that an active life-style during life course reduces brain ...
http://ciafel.fade.up.pt/p_bolsainv.php
Devon mid-air | Wings Over New ZealandDevon mid-air | Wings Over New Zealand
70147 (prev NZ4213969); b Timaru 14 May 23; Wanganui Collegiate; farmer - E A Hall, Bellwood, Timaru. NZ Army/TF 13½ mths; RNZAF Levin as Aircrafthand (ADU) 31 Oct 42, Taieri 4 Dec 42, Ashburton 9 Dec 42, Milson 2 Apr 43, remust as Aircrew u/t & ITW 29 Apr 43, remust as Airman Pilot u/t 24 Jun 43, 2EFTS 26 Jun 43, 1SFTS 28 Aug 43, Pilots Badge [wef 1.11.43] & Comm 23 Dec 43, OSI 31 Dec 43, CFS 15 Jan 44, 2EFTS (Tiger Moth) as FI 14 Mar 44, 3EFTS (Tiger Moth) as FI 19 Aug 44 [att CFS for Harvard conv 21 Oct-13 Nov], 2OTU (P-40) 25 Nov 44, CCU (Corsair) 5 Feb 45, 16 Sqn (Corsair) 12 Mar 45, with Sqn to Pacific 1 Apr 45, rtd with Sqn to NZ 23 Jun 45, with Sqn to Pacific 13 Aug 45, rtd with Sqn to NZ 4 Nov 45, 14 Sqn (Corsair) 1 Dec 45, emb with Sqn on light fleet HMS Glory for Japan 8 Mar 46, arr 26 Mar 46, SSComm 1 Apr 46, rtd to NZ 21 Apr 47, SSComm 1 Apr 47, 41 Sqn (Dakota) 30 May 47, Whenuapai for admin duties 6 Jun 47 [Adj from 27 Jun, att Army Sch Trentham 4-10 Feb 48], CFS (various a/c ...
http://rnzaf.proboards.com/thread/6445/devon-mid-air
Plus itPlus it
Background:. Since the introduction of cisplatin, carboplatin and oxaliplatin, several new generations of platinum analogues have been developed as candidates for chemotherapy. DEBIO 0507/NC-4016 is a DACH-Platin Polymeric Micelle. The main objectives of this project were to assess pharmacokinetic (PK) profile of DEBIO 0507 and evaluate its efficacy in preclinical studies against a broad spectrum of experimental tumors including syngenic, xenogenic tumor models and a cisplatin-resistant cell line.. Methods:. PK and biodistribution studies were conducted in multiple matrices (blood, tumor, liver, spleen, kidneys and pancreas) collected in mice bearing C38 mouse colon carcinoma and treated with a single IV injection of DEBIO 0507 at 2 mg Pt/kg.. Antitumor activity of DEBIO 0507 intravenously injected every 4, 7 or 14 days at different doses was investigated in C38 mouse colon carcinoma bearing C57BL/6 mice. Antitumor effect of DEBIO 0507 was also assessed in a panel of human tumor xenografted in ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/571
IJMS | Free Full-Text | Activated Carbon Modified with Copper for Adsorption of PropanethiolIJMS | Free Full-Text | Activated Carbon Modified with Copper for Adsorption of Propanethiol
Activated carbons were characterized texturally and chemically before and after treatment, using surface area determination in the BET model, Boehm titration, TPR, DRX and immersion calorimetry. The adsorption capacity and the kinetics of sulphur compound removal were determined by gas chromatography. It was established that the propanethiol retention capacity is dependent on the number of oxygenated groups generated on the activated carbon surface and that activated carbon modified with CuO at 0.25 M shows the highest retention of propanethiol. Additionally is proposed a mechanism of decomposition of propenothiol with carbon-copper system.
http://www.mdpi.com/1422-0067/11/3/927
MEXTRA SUPERABSORBENT 12.5CM X 12.5CMMEXTRA SUPERABSORBENT 12.5CM X 12.5CM
|p|Mextra|sup|®|/sup| Superabsorbent addresses three of the important features of a superabsorbent dressing. High absorption capacity|sup|1,2,|/sup| high retention capacity|sup|1|/sup| and excellent conformability|sup|3|/sup|.  Mex
https://store.independenceaustralia.com/mextra-superabsorbent-12-5cm-x-12-5cm.html
Accell siRNAAccell siRNA
Mast cells were purified from human skin of healthy donors according to our routine protocol (e.g. PMID: 14634065, 15191551, 15666093, 15675967, 20545757, 24671954, 25725371, 26706922, 28264498, 28845295, 28859248), reaching 98-100% purity, and transfected with siRNA as specified by the Dharmacon; all siRNAs were used at 1 µM. (A) Cellular uptake of siRNA, as measured by fluorescence microscopy using PE-labeled (non-targeting) siRNA (24 h after transfection). (B) and (C) relative gene expression in cells transfected with non-targeting siRNA versus siRNA targeting either GAPDH or Cyclophilin B, measured by RT-qPCR (48 h post-transfection) and normalized to control expression given as 1. Mean ± SEM of n = 6-9 individual experiments. Note that the knockdown was both highly efficient and specific, as only the targeted RNA was downregulated, while the Cyclophilin B-specific siRNA had no impact on GAPDH expression and vice versa. ** p , 0.01; *** p , 0.01; ****p , 0.0001 by Kruskal-Wallis test with ...
https://horizondiscovery.com/en/products/gene-modulation/knockdown-reagents/sirna/accell-sirna
25th week of 2011 patent applcation highlights part 6425th week of 2011 patent applcation highlights part 64
NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such ...
http://www.patentsencyclopedia.com/hgl/06-23-11/06-23-11_64
FDA Grants Fast Track Designation to Debiopharm Groups Antibiotic Debio 1450 | Medienmitteilung Debiopharm International SAFDA Grants Fast Track Designation to Debiopharm Groups Antibiotic Debio 1450 | Medienmitteilung Debiopharm International SA
Lausanne, Switzerland (ots/PRNewswire) - - Debio 1450, oral/IV FabI inhibitor active against all Staphylococcus species has received Fast Track designation for ABSSSI (acute...
https://www.presseportal.ch/de/pm/100017821/100766851
Sydney Research Online: Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not...
This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party ...
https://sro.library.usyd.edu.au/handle/10765/26704
Liens utiles - PAPPSO
[liste de diffusion pappso-tools] (/mailinglist)Réseaux nationaux en protéomique [Réseau des Plateformes Protéomiques dIle de France] (http://pappso.inra.fr/ppif) [Réseau MassProt’ INRA : huit plateaux de spectrométrie de masse en France] (http://massprot.
http://pappso.inra.fr/liens/
Anti-Cyclophilin 40 抗体 (ab3562) | アブカムAnti-Cyclophilin 40 抗体 (ab3562) | アブカム
ウサギ・ポリクローナル抗体 ab3562 交差種: Ms,Rat,Rb,Chk,Cow,Hu,NHuPrm 適用: WB,IP,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…Cyclophilin…
http://www.abcam.co.jp/cyclophilin-40-antibody-ab3562.html
CyclophilinCyclophilin
Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a calcium/ ... Cyclophilin A is a cytosolic and highly abundant protein. The protein belongs to a family of isozymes, including cyclophilins B ... Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is ... Cyclophilin inhibitors, such as cyclosporin, are being developed to treat neurodegenerative diseases. Cyclophilin inhibition ...
https://en.wikipedia.org/wiki/Cyclophilin
PPIBPPIB
As a cyclophilin, PPIB binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene ... Mikol V, Kallen J, Walkinshaw MD (1994). "X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A ... As a cyclophilin, PPIB binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. PPIB is the ...
https://en.wikipedia.org/wiki/PPIB
PPICPPIC
As a cyclophilin, PPIC binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Depletion of these two cyclophilins lead to hyperoxidation of the ER. In the brain, PPIC complexes with cyclophilin C- ... Like other cyclophilins, PPIC forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ...
https://en.wikipedia.org/wiki/PPIC
PPIFPPIF
As a cyclophilin, PPIF binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Like other cyclophilins, PPIF forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a ...
https://en.wikipedia.org/wiki/PPIF
Peptidylprolyl isomerase DPeptidylprolyl isomerase D
As a cyclophilin, PPID binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on ... Like other cyclophilins, PPID forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ...
https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase_D
PPIE (gene)PPIE (gene)
As a cyclophilin, PPIE also binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on ... Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, Sun L, Gao GF, Ye X, Liu W (2011). "Cyclophilin E functions as a negative ...
https://en.wikipedia.org/wiki/PPIE_(gene)
Peptidylprolyl isomerase APeptidylprolyl isomerase A
Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ... Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by ... Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in ...
https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase_A
BasiginBasigin
... is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... Yurchenko V, Constant S, Bukrinsky M (March 2006). "Dealing with the family: CD147 interactions with cyclophilins". Immunology ...
https://en.wikipedia.org/wiki/Basigin
CLK1CLK1
Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin ...
https://en.wikipedia.org/wiki/CLK1
PPIG (gene)PPIG (gene)
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR ... Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (Jan 1997). "RS cyclophilins: identification of an NK-TR1-related ... "Entrez Gene: PPIG peptidylprolyl isomerase G (cyclophilin G)". Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (Aug 2004). " ... 2004). "The human nuclear SRcyp is a cell cycle-regulated cyclophilin". J. Biol. Chem. 279 (21): 22322-30. doi:10.1074/jbc. ...
https://en.wikipedia.org/wiki/PPIG_(gene)
PRPF3PRPF3
Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a ... Horowitz DS, Lee EJ, Mabon SA, Misteli T (Feb 2002). "A cyclophilin functions in pre-mRNA splicing". The EMBO Journal. 21 (3): ... a nuclear cyclophilin" (PDF). The Journal of Biological Chemistry. 275 (11): 7439-42. doi:10.1074/jbc.275.11.7439. PMID ... "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". Journal of Molecular ...
https://en.wikipedia.org/wiki/PRPF3
ImmunophilinsImmunophilins
FKBP-12 and cyclophilins both share common peptide-prolyl isomerase activity. While the majority of the Peptide bonds within ... These two families are: "cyclosporin-binding cyclophilins (CyPs)" and "FK506-binding proteins (FKBPs)". In 2005, a group of ...
https://en.wikipedia.org/wiki/Immunophilins
RANBP2RANBP2
Ferreira PA, Nakayama TA, Pak WL, Travis GH (Oct 1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green ... Ferreira PA, Yunfei C, Schick D, Roepman R (Sep 1998). "The cyclophilin-like domain mediates the association of Ran-binding ... Yi H, Friedman JL, Ferreira PA (Nov 2007). "The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the ... Ferreira PA, Hom JT, Pak WL (Sep 1995). "Retina-specifically expressed novel subtypes of bovine cyclophilin". The Journal of ...
https://en.wikipedia.org/wiki/RANBP2
PPIL2PPIL2
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ... 2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866-71. doi: ... "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2". Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). " ... 2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. ...
https://en.wikipedia.org/wiki/PPIL2
PPIL3PPIL3
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide ... Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the ... "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high ... cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3-4): 231-6. doi:10.1159/000056909 ...
https://en.wikipedia.org/wiki/PPIL3
PPIL1PPIL1
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved ... "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical ... expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. ...
https://en.wikipedia.org/wiki/PPIL1
Cis-trans isomeraseCis-trans isomerase
Examples include photoisomerase and immunophilins such as cyclophilin. cis-trans-Isomerases at the US National Library of ...
https://en.wikipedia.org/wiki/Cis-trans_isomerase
PPIL4PPIL4
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, ... "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4". Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, ... structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell ...
https://en.wikipedia.org/wiki/PPIL4
AlisporivirAlisporivir
It inhibits cyclophilin A. Alisporivir is not immunosuppressive. It is being researched for potential use in the treatment of ... Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of, and ... April 2008). "Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin ... December 2008). "Debio 025, a cyclophilin binding molecule, is highly efficient in clearing HCV replicon containing cells, ...
https://en.wikipedia.org/wiki/Alisporivir
FKBPFKBP
... which binds cyclophilin. Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called ... Along with cyclophilin, FKBPs belong to the immunophilin family. FKBP12 is notable in humans for binding the immunosuppressant ... FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins ... Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ...
https://en.wikipedia.org/wiki/FKBP
Calcium modulating ligandCalcium modulating ligand
When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein ... Bram RJ, Crabtree GR (1994). "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein". Nature. 371 (6495 ... Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ (2000). "Calcium-modulating cyclophilin ligand desensitizes hormone-evoked ... Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of ...
https://en.wikipedia.org/wiki/Calcium_modulating_ligand
Methods used to study memoryMethods used to study memory
The Role of Cyclophilin D in learning and memory. Brush, F. Robert (2003). "Selection for Differences in avoidance Learning: ...
https://en.wikipedia.org/wiki/Methods_used_to_study_memory
Proline isomerization in epigeneticsProline isomerization in epigenetics
Cyp33 is a cyclophilin that has the ability to isomerize H3 proline residues at P16 and P30 positions. Histones H2A and H2B ... Cyclophilin A uses an "electrostatic handle" to pull proline into cis and trans formations. Most of these biological functions ... PPIases are present in three types: cyclophilins, FK507-binding proteins, and the parvulins. PPIase enzymes catalyze the ...
https://en.wikipedia.org/wiki/Proline_isomerization_in_epigenetics
Ischemia-reperfusion injury of the appendicular musculoskeletal systemIschemia-reperfusion injury of the appendicular musculoskeletal system
To the end of this, necrosis occurs by physical interaction with the PTP regulator cyclophilin D (CypD). The mitochondrial p53- ... Alam, M.R.; D. Baetz; M. Ovize (2015). "Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective". J Mol ...
https://en.wikipedia.org/wiki/Ischemia-reperfusion_injury_of_the_appendicular_musculoskeletal_system
CiclosporinCiclosporin
Cyclosporin A binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, ... It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases ... This cyclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of ... Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding ...
https://en.wikipedia.org/wiki/Ciclosporin
SLC46A3SLC46A3
October 2011). "The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors ...
https://en.wikipedia.org/wiki/SLC46A3
MIF4GDMIF4GD
Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors". PLOS Pathogens. 7 (10): e1002331. doi:10.1371/journal ...
https://en.wikipedia.org/wiki/MIF4GD
ISLRISLR
October 2011). "The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors ...
https://en.wikipedia.org/wiki/ISLR
C20orf27C20orf27
October 2011). "The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors ...
https://en.wikipedia.org/wiki/C20orf27
Hypothermia therapy for neonatal encephalopathyHypothermia therapy for neonatal encephalopathy
February 2009). "Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury". The Journal of ...
https://en.wikipedia.org/wiki/Hypothermia_therapy_for_neonatal_encephalopathy
JCI - Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injuryJCI - Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and ... Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular ...
https://www.jci.org/articles/view/133082/ga
Functional association of cyclophilin A with HIV-1 virions | Semantic ScholarFunctional association of cyclophilin A with HIV-1 virions | Semantic Scholar
CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase ... Drug-induced reductions in virion-associated cyclophilin A levels were accompanied by reductions in virion infectivity, ... The association of cyclophilin A with HIV-1 virions was inhibited in a dose-dependent manner by cyclosporin A as well as by SDZ ... contain significant amounts of cyclophilin A. Sequences in the capsid domain of p55gag are both required and sufficient for the ...
https://www.semanticscholar.org/paper/Functional-association-of-cyclophilin-A-with-HIV-1-Thali-Bukovsky/c13ea026f5aa710c1e374e226e189096319b54df
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCOCyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCO
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. By Shivam Yadav, Martin ... Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. Most of them ... Here, we show that cyclophilin anaCyp40 from the cyanobacterium Anabaena sp. PCC 7120 is enzymatically active, and seems to be ... The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and ...
https://jascoinc.com/knowledgebase/cyclophilin-anacyp40-regulates-photosystem-assembly-and-phycobilisome-association-in-a-cyanobacterium/
RCSB PDB - 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.RCSB PDB - 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.
Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. ... Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.. *PDB DOI: ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ...
https://www.rcsb.org/structure/2WFJ
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70<...
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. A. Carrello, Rudi Allan, Sarah Morgan, B.A.L. Owen, D. Mok, B.K ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. / Carrello, A.; Allan, Rudi; Morgan, Sarah et al. ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. In: Cell Stress & Chaperones. 2004 ; Vol. 9. pp. 167-181. ... Dive into the research topics of Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Together they form a unique ...
https://research-repository.uwa.edu.au/en/publications/interaction-of-the-hsp90-cochaperone-cyclophilin-40-with-hsc70
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic...Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic...
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ... We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB ... Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ...
https://scholars.duke.edu/display/pub800971
Cyclophilin D deficiency prevents diet-induced obesity in mice - Fingerprint - Research Nebraska
Cyclophilin D deficiency prevents diet-induced obesity in mice. Kishor Devalaraja-Narashimha, Alicia M. Diener, Babu J. ... Dive into the research topics of Cyclophilin D deficiency prevents diet-induced obesity in mice. Together they form a unique ...
https://experts.nebraska.edu/en/publications/cyclophilin-d-deficiency-prevents-diet-induced-obesity-in-mice/fingerprints/
Cerebrovascular Insulin Receptors Are Defective in ADCerebrovascular Insulin Receptors Are Defective in AD
Cyclophilin B; EC = Extracellular; IC = Intracellular; O.D. = optical density; P = Microvessel-depleted parenchymal fraction; T ... Cyclophilin B; EC = Extracellular; IC = Intracellular; O.D. = optical density; P = Microvessel-depleted parenchymal fraction; T ...
https://www.medscape.com/viewarticle/986914_2
Rat CYPA (Cyclophilin A) ELISA Kit - BidScientific.com
Rat CYPA (Cyclophilin A) ELISA Kit. E-EL-R0298 Regular price $580.00. $499.00 You Pay ...
https://www.bidscientific.com/products/e-el-r0298
S-EPMC145517 - Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. - OmicsDI
Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 ... cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gags interaction with cyclophilins ... indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific ... Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. ...
https://www.omicsdi.org/dataset/biostudies/S-EPMC145517
Cloning and Expression Analysis of Cyclophilins A(<em>CyPA</em>) Gene...
Cyclophilins (CyPs) are widely distributed in organisms, and play impo... ... Abstract: Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. Cyclophilin A-like was screened in ... Cloning and Expression Analysis of Cyclophilins A(CyPA) Gene form Chlorella WANG Xu-Hui;QIAO Kun;WANG Zhen-Juan;GUAN Qing-Jie*; ... So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in ...
http://bbr.nefu.edu.cn/EN/10.7525/j.issn.1673-5102.2014.02.017
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach<...Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach<...
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. / Ni, Shuaishuai; Yuan, Yaxia ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. In: Journal of Medicinal ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. Journal of Medicinal ... Dive into the research topics of Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design ...
https://scholars.uthscsa.edu/en/publications/discovering-potent-small-molecule-inhibitors-of-cyclophilin-a-usi
Immunosuppression: Practice Essentials, History, DrugsImmunosuppression: Practice Essentials, History, Drugs
It is a polypeptide of 11 amino acids of fungal origin and a prodrug that binds to cyclophilin; complex inhibits calcineurin ... binds to tacrolimus-binding protein instead of cyclophilin protein). The tacrolimus:FKBP12 active complex inhibits calcineurin ...
http://emedicine.medscape.com/article/432316-overview
Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial...Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial...
... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D, Neuroscience, vol. 155, no. 3, pp. 585-596 ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. In: Neuroscience. 2008 ; Vol. 155, No. 3. pp ... encoding mitochondrial cyclophilin D (CyPD). Mitochondrial CyPD is a key modulator of the mitochondrial permeability transition ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. Neuroscience. 2008 Aug 26;155(3):585-596. ...
https://ohsu.pure.elsevier.com/en/publications/enhancement-of-anxiety-facilitation-of-avoidance-behavior-and-occ-2
Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with antifungal...Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with antifungal...
Of which, 65 GhCYPs only contained one cyclophilin type PPIase domain, others 14 GhCYPs contain additional domains. A number of ... Cyclophilins (CYPs), belonging to the peptidyl prolyl cis/trans isomerase (PPIase) superfamily, play important roles during ... From: Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-019-1848-1/figures/3
DeCS - Termos NovosDeCS - Termos Novos
CYCLOPHILINS. CICLOFILINAS. CICLOSPORÍASE. CYCLOSPORIASIS. CICLOSPORIASIS. CIRCULAÇÃO PLACENTÁRIA. PLACENTAL CIRCULATION. ...
https://decs.bvs.br/P/news2001pie.htm
Crosstalk between cyclophilins and T lymphocytes in coronary artery disease | Documentos - Universidade de Santiago de...
Crosstalk between cyclophilins and T lymphocytes in coronary artery disease * Gegunde, S. 12 ...
https://investigacion.usc.gal/documentos/604c18ff96a5c520fe407eea
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...
Twelve of the 17 human cyclophilins and both human parvulins, but only one of the 13 human FKBPs, identified orthologues within ... whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more ... multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle ... whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. A comparison of their known functions ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-7-244
Letters To The EditorLetters To The Editor
Cyclophilin B (CypB) was first described and its sequence was reported by Spik et al. in 1991 (1). These authors prepared and ... Cyclophilin B is really a major growth factor in breast milk. Journal of Biological Chemistry ...
https://www.jbc.org/letters-to-the-editor?startPage=&Ppub=%5B20201125%20TO%2020221125%5D
2igv.1 | SWISS-MODEL Template Library
CYCLOPHILIN 3 Complexed with DIPEPTIDE SER-PRO Coordinates. PDB Format Method. X-RAY DIFFRACTION 1.67 Å. Oligo State. monomer. ...
https://swissmodel.expasy.org/templates/2igv.1
Hypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews NephrologyHypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews Nephrology
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimers mice via cyclophilin A ...
https://www.nature.com/articles/s41581-021-00430-6?error=cookies_not_supported&code=3272588f-a6a7-4334-86f0-aea320dff92d
PPIAP74 peptidylprolyl isomerase A pseudogene 74 [Homo sapiens (human)] - Gene - NCBIPPIAP74 peptidylprolyl isomerase A pseudogene 74 [Homo sapiens (human)] - Gene - NCBI
peptidylprolyl isomerase A (cyclophilin A) pseudogene. NCBI Reference Sequences (RefSeq) Go to the top of the page Help ...
https://www.ncbi.nlm.nih.gov/gene/131055
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to...
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ...
https://www.ibb.cnr.it/?command=search&table=bibliography&idb=54798
Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas...Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas...
Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas ...
https://ir.sinica.edu.tw/handle/201000000A/72334
Common variable immune deficiency: MedlinePlus GeneticsCommon variable immune deficiency: MedlinePlus Genetics
Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand ...
https://medlineplus.gov/genetics/condition/common-variable-immune-deficiency
SARS Coronavirus Detection - Volume 10, Number 7-July 2004 - Emerging Infectious Diseases journal - CDC
Parallel amplification of two human reference genes, L13 and cyclophilin, confirmed negative results in clinical samples by ... The human L13 gene and the human cyclophilin gene (16) were amplified under identical reaction conditions as the SARS-CoV- ... All samples were positive for L13 and cyclophilin control sequences when amplified in parallel. In agreement with the ...
https://wwwnc.cdc.gov/eid/article/10/7/03-0678_article
Fischkoff SA[au] - Search Results - PubMedFischkoff SA[au] - Search Results - PubMed
Leukocyte chemotactic activity of cyclophilin. Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR. Xu Q, et al. Among ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Fischkoff+SA%5Bau%5D&dispmax=50
Potential adverse effects of nanoparticles on the reproductive system | IJNPotential adverse effects of nanoparticles on the reproductive system | IJN
... cyclophilin periplasmic; CdTe, cadmium telluride; COOH, carboxylate; DSP, daily sperm production; E2, estradiol; FLGO, few- ...
https://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-fulltext-article-IJN
Biomolecules | June 2015 - Browse ArticlesBiomolecules | June 2015 - Browse Articles
The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, ... The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, ... The human genome encodes 19 cyclophilins, 18 FKBPs and three parvulins. Immunophilins are receptors for the immunosuppressive ... The human genome encodes 19 cyclophilins, 18 FKBPs and three parvulins. Immunophilins are receptors for the immunosuppressive ...
https://www.mdpi.com/2218-273X/5/2
TCDB » SEARCHTCDB » SEARCH
Cyclophilin B is an accessory activating protein (Stumpf et al., 2008). The crystal structure of rat TRPV6 at 3.25 A resolution ...
https://tcdb.org/search/result.php?tc=1.A.4.2.11
CyPAProteinPPIaseActivity of cyclophilinIsomeraseMitochondrialImmunophilinsCyclosporinGeneSmall moleculeInhibitorsCyPsLigandCypBInteractsProlylArabidopsisMiceSurvivalExpressionCompoundsFunctionalAnalysisRoleDomainStudy
CyPA6
  • Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. (omicsdi.org)
  • Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis-trans isomerases (PPIases), which can bind to cyclosporin A (CsA). (omicsdi.org)
  • So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in improving survival ability of resistant organisms. (nefu.edu.cn)
  • Cloning and Expression Analysis of Cyclophilins A( CyPA ) Gene form Chlorella[J]. Bulletin of Botanical Research, 2014, 34(2): 245-251. (nefu.edu.cn)
  • This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3). (uthscsa.edu)
  • Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. (cnr.it)
Protein7
  • Cyclophilin A acts as protein folding chaperones and intracellular transports in many cellular processes. (omicsdi.org)
  • Previous studies have shown that cyclophilin A can interact with HIV-1 (human immunodeficiency virus type 1) gag protein and enhance viral infectivity. (omicsdi.org)
  • A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
  • Cyclophilin B is an accessory activating protein ( Stumpf et al . (tcdb.org)
  • Here, we show that thymocytes lacking the endoplasmic reticulum protein calcium-modulating cyclophilin ligand (CAML) failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis. (elsevier.com)
  • Each sample was analyzed for the expression of two candidate genes, aromatase (CYP19) and peroxisome proliferator activated receptor protein gamma (PPARgamma) and three potential internal controls: cyclophilin (CYC), 18S rRNA (18S), and total RNA. (cdc.gov)
PPIase3
  • 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. (rcsb.org)
  • Following a computer-aided virtual screening and subsequent surface plasmon resonance (SPR) analysis, 12 low molecular weight cyclophilin A ligands were selected for further evaluation of their in vitro inhibition of peptidyl-prolyl cis-trans isomerase (PPIase) activity of cyclophilin A and HIV-1 replication. (omicsdi.org)
  • Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. (biomedcentral.com)
Activity of cyclophilin1
  • Leukocyte chemotactic activity of cyclophilin. (nih.gov)
Isomerase1
  • CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase activity, and assist in the folding of proteins1 6. (semanticscholar.org)
Mitochondrial5
  • In neonatal mice and cultured differentiating oligodendrocytes, sublethal intermittent hypoxic (IH) stress activated cyclophilin D-dependent mitochondrial proton leak and uncoupled mitochondrial respiration, leading to transient bioenergetic stress. (jci.org)
  • Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular mechanism for the maturational failure of oligodendrocytes and offers a potential therapeutic target for prevention of diffuse WMI in premature infants experiencing chronic IH stress. (jci.org)
  • In this report, we have assessed the behavioral responses of mice missing the Ppif gene (CyPD-KO), encoding mitochondrial cyclophilin D (CyPD). (elsevier.com)
  • Dive into the research topics of 'Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D'. Together they form a unique fingerprint. (elsevier.com)
  • Several NSAIDs indeed trigger increases in mobile [Ca2+] and oxidant tension (Tanaka research with cultured enterocytes, where high concentrations of diclofenac could actually trigger cyclosporin ACsensitive adjustments in calcein/Co2+ fluorescence, a recognized indicator from the mPT (LoGuidice by focusing on cyclophilin D (CypD), a mitochondrial matrix proteins and important regulator from the mPT. (cancerhugs.com)
Immunophilins2
  • Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. (jascoinc.com)
  • Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. (usc.es)
Cyclosporin5
  • Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. (semanticscholar.org)
  • HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. (omicsdi.org)
  • Many cyclophilin A inhibitors such as cyclosporin A can inhibit HIV-1 replication in vitro. (omicsdi.org)
  • Certain drugs of the cyclosporine family, such as cyclosporin A (CsA), are reversible inhibitors of mPT via direct interaction with cyclophilin D, which is a known part of the pore forming complex. (lu.se)
  • In a successive evaluation of 12 putative mPT inhibiting compounds, none displayed effects comparable to cyclophilin D inhibition by the non-immunosuppressive cyclophilin inhibitor D-MeAla3-EtVal4-Cyclosporin (Debio 025). (lu.se)
Gene3
  • Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (omicsdi.org)
  • Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression. (cdc.gov)
  • Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (cdc.gov)
Small molecule1
  • Structure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity. (omicsdi.org)
Inhibitors2
  • Here, we report a structure-based identification of novel non-peptidic cyclophilin A inhibitors as anti-HIV lead compounds. (omicsdi.org)
  • Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. (omicsdi.org)
CyPs1
  • Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. (nefu.edu.cn)
Ligand1
  • Cyclophilin A complexed with the tri-vector ligand 8. (berkeley.edu)
CypB1
  • We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB). (duke.edu)
Interacts1
  • Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (rochester.edu)
Prolyl1
  • The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. (omicsdi.org)
Arabidopsis2
  • The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and presents features that are absent in single-domain cyclophilins. (jascoinc.com)
  • Prokaryotic Expression,Activity Assay of Chlorella Cyclophilin A and Salt Tolerance Analysis of Arabidopsis Over-expressing CsCyp1A [J]. Bulletin of Botanical Research, 2017, 37(5): 722-729. (nefu.edu.cn)
Mice2
  • Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and fully preserved oligodendrocyte maturation, axonal myelination, and neurofunction. (jci.org)
  • Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone. (rochester.edu)
Survival1
  • Cyclophilin A enhanced the survival rate of PC12 cells to Aβ_(25-35)-induced apoptosis (t = 4.895, 10.042, P (imr.ac.cn)
Expression4
  • Cells in the cyclophilin A group were incubated in medium containing a final con-centration of 10 nmol/L of cyclophilin A for 30 minutes, and then treated with 10 μmol/L Aβ_(25-35).MAIN OUTCOME MEASURES: After 24 hours of culture, immunohistochemistry was used to detect Bcl-2 and Bax expression in PC12 cells. (imr.ac.cn)
  • However, in PC12 cells treated with Aβ_(25-35) and cyclophilin A, Bcl-2 expression increased and Bax expression decreased (t = 4.497, 2.531, P (imr.ac.cn)
  • CONCLUSION: Cyclophilin A can increase Bcl-2 expression and decrease Bax expression in PC12 cells treated with Aβ_(25-35), which indicates that cyclophilin A has a protective effect on Aβ_(25-35)-induced injury to PC12 cells. (imr.ac.cn)
  • Bioinformatic and expression analysis of the Brassica napus L. cyclophilins. (mpg.de)
Compounds1
  • These active compounds will be used as leads for structure and activity relationship (SAR) and optimization studies in order to design more effective anti-HIV-1 therapeutics, and as probes for investigating the effect of cyclophilins on HIV-1 replication. (omicsdi.org)
Functional1
  • These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophin A to initiate infection. (semanticscholar.org)
Analysis1
  • Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. (biomedcentral.com)
Role2
  • Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. (semanticscholar.org)
  • Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation. (rochester.edu)
Domain1
  • Elucidation of the anaCyp40 crystal structure at 1.2-Å resolution reveals an N-terminal helical domain with similarity to PsbQ components of plant photosystem II, and a C-terminal cyclophilin domain with a substrate-binding site. (jascoinc.com)
Study2
  • Cyclophilin A-like was screened in our study from Chlorella sp. (nefu.edu.cn)
  • Aβ_(25-35) (Sigma, USA), antibodies of Bcl-2 and Bax (Wuhan Boster, China), and recombinant human cyclophilin A (Biomol, USA) were used in this study. (imr.ac.cn)
Immunosuppression: Practice Essentials, History, Drugs
Immunosuppression: Practice Essentials, History, Drugs (medscape.com)
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full... (bmcgenomics.biomedcentral.com)
Hypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews Nephrology
Hypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews Nephrology (nature.com)
Functional association of cyclophilin A with HIV-1 virions | Semantic Scholar
Functional association of cyclophilin A with HIV-1 virions | Semantic Scholar (semanticscholar.org)
Common variable immune deficiency: MedlinePlus Genetics
Common variable immune deficiency: MedlinePlus Genetics (medlineplus.gov)
TNFRSF13B gene: MedlinePlus Genetics
TNFRSF13B gene: MedlinePlus Genetics (medlineplus.gov)
1D PFV: 1CWB
1D PFV: 1CWB (rcsb.org)
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCO
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCO (jascoinc.com)
Publications | Max Planck Institute of Biochemistry
Publications | Max Planck Institute of Biochemistry (biochem.mpg.de)
Materials | Free Full-Text | Gene Expression, Bacteria Viability and Survivability Following Spray Drying of Mycobacterium...
Materials | Free Full-Text | Gene Expression, Bacteria Viability and Survivability Following Spray Drying of Mycobacterium... (mdpi.com)
Potential adverse effects of nanoparticles on the reproductive system | IJN
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Genome-Wide Characterization of Peptidyl-Prolyl Cis-Trans Isomerases in Penicillium and Their Regulation By Salt...
Genome-Wide Characterization of Peptidyl-Prolyl Cis-Trans Isomerases in Penicillium and Their Regulation By Salt... (researchsquare.com)
Pediatric Common Variable Immunodeficiency Treatment & Management: Medical Care, Immunoglobulin Replacement Therapy,...
Pediatric Common Variable Immunodeficiency Treatment & Management: Medical Care, Immunoglobulin Replacement Therapy,... (medscape.com)
Search Results
Search Results (biolegend.com)
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Pediatric Nephrotic Syndrome Medication: Glucocorticoids, Diuretics, Plasma protein, Immunosuppressive agents, Antineoplastics,...
Pediatric Nephrotic Syndrome Medication: Glucocorticoids, Diuretics, Plasma protein, Immunosuppressive agents, Antineoplastics,... (medscape.com)
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70<...
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70<... (research-repository.uwa.edu.au)
SCOP 1.65: Species: Cow (Bos taurus)
SCOP 1.65: Species: Cow (Bos taurus) (scop.berkeley.edu)
Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and...
Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and... (portal.research.lu.se)
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription...
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription... (nature.com)
Frontiers | Advances in Foot-and-Mouth Disease Virus Proteins Regulating Host Innate Immunity
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Ola Myklebost | Universitetet i Bergen
Ola Myklebost | Universitetet i Bergen (uib.no)
Plus it
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Therapy for Hepatitis C Genotype 3: Moving Forward
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Therapy for Hepatitis C Genotype 3: Moving Forward
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