A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Transport proteins that carry specific substances in the blood or across cell membranes.
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides. (From Enzyme Nomenclature, 1992) EC 3.4.21.62.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.
A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
Established cell cultures that have the potential to propagate indefinitely.
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Proteins which bind calmodulin. They are found in many tissues and have a variety of functions including F-actin cross-linking properties, inhibition of cyclic nucleotide phosphodiesterase and calcium and magnesium ATPases.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A subtype of thioredoxins found primarily in CHLOROPLASTS.
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
A family of RNA plant viruses infecting disparate plant families. They are transmitted by specific aphid vectors. There are three genera: LUTEOVIRUS; Polerovirus; and Enamovirus.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.
Proteins prepared by recombinant DNA technology.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).

Cyclophilin A is a secreted growth factor induced by oxidative stress. (1/314)

Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis, hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. Many VSMC growth factors are secreted by VSMC and act in an autocrine manner. Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Human recombinant CyPA can mimic the effects of secreted CyPA to stimulate ERK1/2 and cell growth. The peptidyl-prolyl isomerase activity is required for ERK1/2 activation by CyPA. In vivo, CyPA expression and secretion are increased by oxidative stress and vascular injury. These findings are the first to identify CyPA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases.  (+info)

Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (2/314)

The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. To determine whether CypA promotes HIV-1 replication, we deleted the gene encoding CypA (PPIA) in human CD4(+) T cells by homologous recombination. HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific for wild-type HIV-1 since HIV-2/SIV isolates, as well as HIV-1 bearing a gag mutation that confers cyclosporin resistance, replicated the same in PPIA(+/+) and PPIA(-/-) cells. Stable re-expression of CypA in PPIA(-/-) cells restored HIV-1 replication to an extent that correlated with steady-state levels of CypA. Finally, virions from PPIA(-/-) cells possessed no obvious biochemical abnormalities but were less infectious than virions from wild-type cells. These data formally demonstrate that CypA regulates the infectivity of HIV-1 virions.  (+info)

Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. (3/314)

Caveolin-1 is a palmitoylated protein involved in assembly of signaling molecules in plasma membrane subdomains termed caveolae and in intracellular cholesterol transport. Three cysteine residues in the C terminus of caveolin-1 are subject to palmitoylation, which is not necessary for caveolar targeting of caveolin-1. Protein palmitoylation is a post-translational and reversible modification that may be regulated and that in turn may regulate conformation, membrane association, protein-protein interactions, and intracellular localization of the target protein. We have undertaken a detailed analysis of [(3)H]palmitate incorporation into caveolin-1 in aortic endothelial cells. The linkage of palmitate to caveolin-1 was hydroxylamine-sensitive and thus presumably a thioester bond. However, contrary to expectations, palmitate incorporation was blocked completely by the protein synthesis inhibitors cycloheximide and puromycin. In parallel experiments to show specificity, palmitoylation of aortic endothelial cell-specific nitric-oxide synthase was unaffected by these reagents. Inhibitors of protein trafficking, brefeldin A and monensin, blocked caveolin-1 palmitoylation, indicating that the modification was not cotranslational but rather required caveolin-1 transport from the endoplasmic reticulum and Golgi to the plasma membrane. In addition, immunophilin chaperones that form complexes with caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary for caveolin-1 palmitoylation because agents that bind immunophilins did not inhibit palmitoylation. Pulse-chase experiments showed that caveolin-1 palmitoylation is essentially irreversible because the release of [(3)H]palmitate was not significant even after 24 h. These results show that [(3)H]palmitate incorporation is limited to newly synthesized caveolin-1, not because incorporation only occurs during synthesis but because the continuous presence of palmitate on caveolin-1 prevents subsequent repalmitoylation.  (+info)

Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein. (4/314)

While several cellular proteins are incorporated in the human immunodeficiency virus type 1 virion, cyclophilin (CyP) A is the only one whose absence has been demonstrated to impair infectivity. Incorporation of the cytosolic protein results from interaction with a highly exposed Pro-rich loop in the N-terminal region of the capsid (CA) domain of the precursor polyprotein, Pr55(Gag). Even when prevented from interacting with CyP A, Pr55Gag still forms particles that proceed to mature into morphologically wild-type virions, suggesting that CyP A influences a postassembly event. The nature of this CyP A influence has yet to be elucidated. Here, we show that while CyP A binds both Gag and mature CA proteins, the two binding interactions are actually different. Tryptophan 121 (W121) in CyP A distinguished the two proteins: a phenylalanine substitution (W121F) impaired binding of mature CA protein but not of Gag. This indicates the occurrence of a maturation-dependent switch in the conformation of the Pro-rich loop. A structural consequence of Gag binding to CyP A was to block this maturational refolding, resulting in a 24-kDa CA protein retaining the immature Pro-rich loop conformation. Using trypsin as a structure probe, we demonstrate that the conformation of the C-terminal region in mature CA is also a product of maturational refolding. Binding to wild-type CyP A altered this conformation, as indicated by a reduction in the accessibility of Cys residue(s) in the region to chemical modification. Hence, the end result of binding to CyP A, whether the Pro-rich loop is in the context of Gag or mature CA protein, is a structurally modified mature CA protein. The postassembly role of CyP A may be mediated through these modified mature CA proteins.  (+info)

Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle. (5/314)

Sanglifehrin A (SFA) is a novel immunosuppressive natural product that binds to cyclophilin but is structurally distinct from cyclosporin A (CsA). We have investigated the cellular and molecular mechanisms of the action of SFA in T lymphocytes. We show that SFA inhibits T cell proliferation induced by IL-2 with an IC(50) of 200 nM. Distinct from CsA, which also binds to cyclophilin, SFA does not affect calcium-dependent IL-2 production, although SFA enhanced IL-2 gene transcription in the same cells. SFA blocks T cell proliferation induced by IL-2 in G(1) with no appreciable effect on IL-2 receptor expression in a manner similar to that of the immunosuppressant rapamycin. Unlike rapamycin, however, SFA has no effect on the phosphorylation or enzymatic activity of p70(s6k) kinase, distinguishing SFA from rapamycin in their mode of action. SFA inhibits hyperphosphorylation of Rb and the activity of cyclin E-cyclin-dependent kinase 2 on IL-2 signaling. These results suggest that SFA has a novel mode of action in comparison with CsA, FK506, and rapamycin, and that its use as a molecular probe may lead to the discovery of a novel target involved in T cell activation.  (+info)

CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. (6/314)

Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies implicated CD147 as a receptor for extracellular CyPA. Here, we demonstrate a role for CyPA-CD147 interaction during the early steps of HIV-1 infection. Expression of human CD147 increased infection by HIV-1 under one-cycle conditions. However, susceptibility to infection by viruses lacking CyPA (simian immunodeficiency virus or HIV-1 produced in the presence of cyclosporin A) was unaffected by CD147. Virus-associated CyPA coimmunoprecipitated with CD147 from infected cells. Antibody to CD147 inhibited HIV-1 entry as evidenced by the delay in translocation of the HIV-1 core proteins from the membrane and inhibition of viral reverse transcription. Viruses whose replication did not require CyPA (SIV or mutant HIV-1) were resistant to the inhibitory effect of anti-CD147 antibody. These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell.  (+info)

A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding. (7/314)

The folding of apo-pseudoazurin, a 123-residue, predominantly beta-sheet protein with a complex Greek key topology, has been investigated using several biophysical techniques. Kinetic analysis of refolding using far- and near-ultraviolet circular dichroism (UV CD) shows that the protein folds slowly to the native state with rate constants of 0.04 and 0.03 min(-1), respectively, at pH 7.0 and at 15 degrees C. This process has an activation enthalpy of approximately 90 kJ/mole and is catalyzed by cyclophilin A, indicating that folding is limited by trans-cis proline isomerization, presumably around the Xaa-Pro 20 bond that is in the cis isomer in the native state. Before proline isomerization, an intermediate accumulates during folding. This species has a substantial signal in the far-UV CD, a nonnative signal in the near-UV CD, exposed hydrophobic surfaces (judged by 1-anilino naphthalenesulphonate binding), a noncooperative denaturation transition, and a dynamic structure (revealed by line broadening on the nuclear magnetic resonance time scale). We compare the properties of this intermediate with partially folded states of other proteins and discuss its role in folding of this complex Greek key protein.  (+info)

Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. (8/314)

Six distinct peroxiredoxin (Prx) proteins (Prx I-VI) from distinct genes have been identified in mammalian tissues. Prxs are members of a group of peroxidases that have conserved reactive cysteine residue(s) in the active site(s). An immediate physiological electron donor for the peroxidase catalysis for five Prx proteins (Prx I-V) has been identified as thioredoxin (Trx), but that for Prx VI (1-Cys Prx) is still unclear. To identify an immediate electron donor and a binding protein for Prx VI, we performed a Prx VI protein overlay assay. A 20-kDa binding protein was identified by the Prx VI protein overlay assay with flow-through fractions from a High-Q column with rat lung crude extracts. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and MS-Fit, we identified the 20-kDa Prx VI-binding protein as a cyclophilin A (CyP-A). The binding of recombinant human CyP-A (hCyP-A) to Prx VI was confirmed by using the hCyP-A protein overlay assay and Western immunoblot analysis with hCyP-A-specific antibodies. hCyP-A enhanced the antioxidant activity of Prx VI, as well as the other known mammalian Prx isotypes. hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems. Prx II was reduced by hCyP-A without help from any other reductant, and the reduction was cyclosporin A-independent. These results strongly suggest that CyP-A not only binds to Prx proteins but also supports its peroxidase activity as an immediate electron donor. In addition, Cys(115) and Cys(161) of hCyP-A were found to be involved in the activation and the reduction of Prx.  (+info)

Cyclophilin (Cyp) A has been reported to be overexpressed in the majority of cancer cells, including hepatocellular carcinoma (HCC). However, the biological functions of CypA in HCC are far from being understood. To determine the biological functions of CypA in HCC, the present study screened human fetal liver complementary DNA for proteins interacting with CypA using the yeast two-hybrid system. A nuclear protein, serine/arginine-rich (SR)-25, was isolated as a novel CypA-binding protein that is distinct from those previously described in the literature. Binding assays and co-immunoprecipitation confirmed the physical association between CypA and SR-25. The present study demonstrated that CypA may interact with SR-25 through its peptidyl-prolyl isomerase domain. In addition, CypA may induce the expression of SR-25 in Hep3B cells. The messenger RNA levels of CypA and SR-25 in HCC indicated that there was a significant correlation between the expression of CypA and the expression of SR-25 in HCC. It can
Optimal HIV-1 infectivity requires the presence of both the viral factor Nef and the cellular protein cyclophilin A (CyPA) during virion assembly. These two proteins are integral components of HIV-1 particles. Both CyPA and Nef facilitate a step in the viral life cycle occurring between penetration …
The host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral capsid (CA). CypA enhances the early stages of HIV-1 infection in part by promoting nuclear import of the virus; while the details of its ability to inhibit HIV-1 infection are less clear. This thesis advances our understanding of the mechanisms underlying the ability of CypA to inhibit HIV-1 infection. I demonstrate that CypA inhibits nuclear import of HIV-1 in the presence of inhibitory capsid-binding host proteins TRIM5α and CPSF6, and that inhibition is not a consequence of increased binding of inhibitory factors to the viral capsid. My work also demonstrates that CypA-dependent inhibition depends in part, on a conserved domain of HIV-1 CA which determines interactions with host nuclear pore proteins. These results suggest a common mechanism underlies the ability of CypA to stimulate HIV-1 infectivity in some cells and to inhibit infection in others. ...
Cyclophilin H / PPIH, 0.5 mg. Cyclophilin H (also known as peptidylpropyl isomerase H, PPIH) is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Background: Cyclophilin A (CyPA, encoded by Ppia) is a ubiquitously expressed protein secreted in response to pro-inflammatory stimuli. CyPA stimulates VSMC migration and proliferation, endothelial cell adhesion molecule expression and inflammatory cell chemotaxis. Given these activities, we hypothesized that CyPA is pro-atherogenic.. Methods and Results: In the high cholesterol diet fed Apoe-/- mouse CyPA deficiency led to a reduction of atherosclerosis (% Oil Red O, en face aorta; 19.3±7.5 in Apoe-/- vs. 8.2±2.0 in Apoe-/-Ppia-/- mice, P,0.01). CyPA deficiency was associated with decreased LDL uptake, inflammatory cell accumulation, and apoptosis. Moreover, en face staining of aortic tissues showed that VCAM-1 expression was significantly reduced in mice lacking CyPA. Importantly, eNOS protein expression was significantly higher in the Apoe-/-Ppia-/- mice compared to Apoe-/- mice. To define the mechanisms responsible for decreased eNOS expression, the effect of altering CyPA levels in ...
References for Abcams Recombinant human Cyclophilin 40 protein (ab78815). Please let us know if you have used this product in your publication
Recombinant Human Cyclophilin E protein (His tag) is an Escherichia coli Full length protein 2 to 301 aa range, | 95% purity, | 1.000 Eu/µg endotoxin level and validated in SDS-PAGE, MS.
When human immundeficiency virus (HIV) infects a human cell, it releases into the interior of the cell its capsid (made of about 1,300 identical so-called CA proteins), a closed, stable container that protects the viral genetic material (see also June 2013 highlight Elusive HIV-1 Capsid and August 2015 highlight Anatomy of a Dormant Killer). Once in the cell ― while avoiding detection by cellular proteins ― the capsid deceives the cell and directs the cell machinery to transport it to the nucleus. The human-cell protein Cyclophilin A (CypA) is thereby exploited to act against the cells well being and to assist the HIV infection by getting the capsid to access the cell nucleus; this results in a delicate choreography accomplished by escaping anti-viral proteins in the cell and deceiving transport proteins at the nucleus, all of which contain a CypA domain that interacts directly with the capsid. Despite the availability of the crystal structure of the complex of CypA and CA proteins ...
NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such ...
Researchers at the University of Rochester Medical Center in New York said removing the gene that makes the protein cyclophilin A protected mice genetica
The HIV-1 capsid is an important determinant of viral replication. Early studies demonstrated the intrinsic importance of the capsid in mediating uncoating of t...
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
|strong|Goat anti Human TRIM5 alpha antibody|/strong| recognizes an epitope within the N-terminal (NT) region of human TRIM5alpha, otherwise known as RNF88 (RING finger protein 88), a cytoplasmic pro…
ウサギ・ポリクローナル抗体 ab3562 交差種: Ms,Rat,Rb,Chk,Cow,Hu,NHuPrm 適用: WB,IP,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…Cyclophilin…
Does Modere Trim help you lose weight? Read our Modere Trim review for ingredients, pros, cons, how it works, faq, price, and more!
购买TRIM50兔多克隆抗体(ab90906),TRIM50抗体经WB验证,可与人样本反应。产品出库一年都在质保范围内。中国现货速达。
TRIM41兔多克隆抗体(ab98170)可与人样本反应并经WB, IP, ICC/IF实验严格验证并得到3个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
Looking for online definition of cyclophilin in the Medical Dictionary? cyclophilin explanation free. What is cyclophilin? Meaning of cyclophilin medical term. What does cyclophilin mean?
TY - JOUR. T1 - Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?. AU - Sigal, N. H.. AU - Dumont, F.. AU - Durette, P.. AU - Siekierka, John. AU - Peterson, L.. AU - Rich, D. H.. AU - Dunlap, B. E.. AU - Staruch, M. J.. AU - Melino, M. R.. AU - Koprak, S. L.. AU - Williams, D.. AU - Witzel, B.. AU - Pisano, J. M.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In this report we have approached two questions relating to the mechanism of action of cyclosporin A (CsA). First, we address whether the major cytosolic protein for CsA, cyclophilin, is directly involved in mediating the immunosuppressive activity of this drug, and, in particular, whether inhibition of this proteins peptidyl-prolyl cis-trans isomerase (PPIase) activity results in inhibition of murine T cell activation. Second, we ask whether the nephrotoxicity observed with CsA is related to inhibition of PPIase-dependent pathways in cells other than lymphocytes. Using a series of 61 cyclosporin ...
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA probably interacts directly with nonstructural protein 5A to exert its effect, through its peptidyl-prolyl isomerase activity, on maintaining the proper structure and function of the HCV replicase. The major proline substrates are located in domain II of NS5A, centered around a
The mitochondrial permeability transition pore (PTP) has been established as an important mediator of ischemia-reperfusion-induced cell death. The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. Therefore, the authors hypothesized that isoflurane, by inhibiting the re...
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of ...
Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is over-expressed in prostate cancer and certain T-cell lymphomas. The groove for Hsp90 binding on the TPR domain includes residues Lys227 and Lys308, referred to as the carboxylate clamp, and is essential for Cyp40-Hsp90 binding. In this study, the effect of two mutations, K227A and K308A, and their combinative mutant was investigated by performing a total of 5.76 mu s of all-atom molecular dynamics (MD) simulations in explicit solvent. All simulations, except the K308A mutant, were found to adopt two distinct (extended or compact) conformers defined by different cyclophilin-TPR interdomain distances. The K308A mutant was only observed in the extended form which is observed in the Cyp40 X-ray structure. The wild-type, K227A, and ...
Due to the increase of antifungal drug resistance and difficulties associated with drug administration, new antifungal agents for invasive fungal infections are needed. SCY-247 is a second-generation fungerp antifungal compound that interferes with the synthesis of the fungal cell wall polymer β-(1,3)-d-glucan. We conducted an extensive antifungal screen of SCY-247 against yeast and mold strains compared with the parent compound ibrexafungerp (IBX; formerly SCY-078) to evaluate the in vitro antifungal properties of SCY-247. SCY-247 demonstrated similar activity to IBX against all of the organisms tested. Moreover, SCY-247 showed a higher percentage of fungicidal activity against the panel of yeast and mold isolates than IBX. Notably, SCY-247 showed considerable antifungal properties against numerous strains of Candida auris. Additionally, SCY-247 retained its antifungal activity when evaluated in the presence of synthetic urine, indicating that SCY-247 maintains activity and structural ...
1) Bosco, D.A., Eisenmesser, E.Z., Clarkson, M.W., Wolf-Watz, M., Labeikovsky, W., Millet, O., & Kern, D. (2010). Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the biological substrate HIV-capsid by NMR Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.08.001. 2) Bosco, D.A., Eisenmesser, E.Z., Pochapsky, S., Sunquist, W.I., and Kern, D. (2002) Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proceedings of the National Academy of Sciences, 99(8), 5247-5252. DOI: 10.1073/pnas.082100499. 3) Braaten, D., & Luban, J. (2001). Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells The EMBO Journal, 20 (6), 1300-1309 DOI: 10.1093/emboj/20.6.1300 OPEN ACCESS. 4) Dorfman, T., Weimann, A., Borsetti, A., Walsh, C.T., & Göttlinger, H.G. (1997). Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions. Journal of Virology, 71 (9), ...
To find and calibrate a robust and reliable computational protocol for mapping conformational space of medium-sized molecules, exhaustive conformational sampling has been carried out for the series of seven macrocyclic compounds of varying ring size and one acyclic analogue. While five of them were taken from the MD/LLMOD/force-field study by Shelley and coworkers (J. Chem. Inf. MODEL: 2014, 54, 2680), three represent potential macrocyclic inhibitors of human cyclophilin A. The free energy values (GDFT/COSMO-RS) for all conformers of each compound were obtained by the composite protocol based on the in vacuo quantum mechanics (DFT-D3 method in a large basis set), standard gas-phase thermodynamics and the COSMO-RS solvation model (QM+COSMO-RS ...
Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet …
3RCL: Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
ProSpecs Cyclophilins include: Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant
PPIL1 antibody [N1C3] (peptidylprolyl isomerase (cyclophilin)-like 1) for ICC/IF, WB. Anti-PPIL1 pAb (GTX118126) is tested in Human samples. 100% Ab-Assurance.
SWISS-MODEL Template Library (SMTL) entry for 5ta4.1. Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A
ARZNEIMITTELENTWICKLUNG + ARZNEIMITTELDESIGN + ARZNEIMITTELENTDECKUNG; ORGANISCHE SYNTHESE (CHEMIE); PEPTIDYLPROLYL-ISOMERASE, CYCLOPHILIN (ENZYME); ENZYMINHIBITOREN (BIOCHEMIE); DRUG DEVELOPMENT + DRUG DESIGN + DRUG DISCOVERY (PHARMACY); ORGANIC SYNTHESIS (CHEMISTRY); PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN (ENZYMES); ENZYME INHIBITORS (BIOCHEMISTRY ...
Cyclophilin-D Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 178 aa having a molecular mass of 18.9kDa.
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Keywords: HIV; Herpes; Host Factors; Host-Pathogen Interactions; Innate Immunity; Infection; Viruses; Restriction; Cyclophilin; TRIM5; Tetherin; Tropism; Gene ...
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1-(4-hydroxy-3-methoxyphenyl)propan-1-one 1835-14-9 NMR spectrum, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one H-NMR spectral analysis, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one C-NMR spectral analysis ect.
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis-trans isomerases (PPIases). Our earlier in silico based approach resulted into the identification of cyclophilin family from rice, Arabidopsis and yeast. In our recent report, we discovered a new OsCYP-25 from rice. Here, we identified a novel cyclophylin A-like protein (PiCyP) from Piriformospora indica which is responsible for abiotic stress tolerance in E. coli. Cyclophylin A-like protein (CyPA) (accession number GQ214003) was selected from cDNA library. The genomic organization CyPA revealed a 1304 bp of CyPA in P. indica genome, showing 10 exons and 9 introns. Further, CyPA was evident in PCR with gDNA and cDNA and Southern blot analysis. The phylogenetic examination of CyPA of P. indica showed that it is closed to human cyclophilin. The uniqueness of PiCyPA protein was apparent in western blot
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Rat CYPB(Cyclophilin B) ELISA Kit based in Delhi, India
TY - JOUR. T1 - Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin. AU - Cirillo, Raffaele. AU - Triggiani, Massimo. AU - Siri, Lorenzo. AU - Ciccarelli, Anna. AU - Pettit, George. AU - Condorelli, Mario. AU - Marone, Gianni. PY - 1990. Y1 - 1990. N2 - We have examined the effects of cyclosporin A (CsA) and a series of CsA analogs that bind with decreasing affinity to cyclophilin, to evaluate the involvement of this protein in the release of preformed (histamine) and de novo synthesized (peptide leukotriene C4; LTC4) mediators of inflammatory reactions from human basophils. CsA (8 to 800 nM) concentration-dependently inhibited (5 to 60%) histamine release from peripheral blood basophils challenged with anti-IgE. CsA was more potent (92.6 ± 1.8 vs 59.1 ± 4.5%; p , 0.001) and, at low concentrations, more effective when the channel-operated influx of Ca2+ as bypassed by the ionophore A23187 (IC40 = 24.1 ± 3.9 vs 105.5 ± 22.2 nM; p , ...
Cyclophilin antibody for detecting human peptidyl-prolyl cis-trans isomerase A. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
Molecular Plant-Microbe Interactions 14:1384-1394...Katarzyna Nuc , 1 Przemysław Nuc , 1 , 2 and Ryszard Słomski 1...© 2001 The American Phytopathological Society...Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an intronless gene coding for cytosolic CyP have been isolated from yellow lupine. The deduced amino acid sequence of the characterized open reading frame shows approximately 80% homol...
Cyclophilin B, 0.1 ml. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
A validated positive silencing control targeting the Cyclophilin B (PPIB) gene in human, mouse, or rat cell lines. Useful for determination of optimal RNAi experimental conditions
Figure 3. Genetically encoded N-epsilon lysine acetylation allows the high resolution X-ray structures of acetylated proteins and their complexes to be solved. The high resolution structure of acetyl lysine from acetylated cyclophilin (left) showing the experimental density. Right, Acetylated cyclophilin in complex with cyclosporine. Water molecules (blue spheres) that are ordered at the protein small molecule interface in the unacetylated complex) rearrange in the acetylated complex.. The acetylation of a cyclophilin at Lys125 was identified in a proteomics screen. We subsequently demonstrated that a substantial proportion of CYPA is acetylated in HeLa cells and human T cell lines, suggesting that the acetylated form of the protein is biologically relevant. To test this, recombinant CYPA bearing homogenous acetylation at Lys125 was prepared by overexpression in E. coli using an acetyllysyl-tRNA synthetase-tRNACUA pair, allowing detailed biophysical and enzymatic characterization of acetylated ...
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
Mast cells were purified from human skin of healthy donors according to our routine protocol (e.g. PMID: 14634065, 15191551, 15666093, 15675967, 20545757, 24671954, 25725371, 26706922, 28264498, 28845295, 28859248), reaching 98-100% purity, and transfected with siRNA as specified by the Dharmacon; all siRNAs were used at 1 µM. (A) Cellular uptake of siRNA, as measured by fluorescence microscopy using PE-labeled (non-targeting) siRNA (24 h after transfection). (B) and (C) relative gene expression in cells transfected with non-targeting siRNA versus siRNA targeting either GAPDH or Cyclophilin B, measured by RT-qPCR (48 h post-transfection) and normalized to control expression given as 1. Mean ± SEM of n = 6-9 individual experiments. Note that the knockdown was both highly efficient and specific, as only the targeted RNA was downregulated, while the Cyclophilin B-specific siRNA had no impact on GAPDH expression and vice versa. ** p , 0.01; *** p , 0.01; ****p , 0.0001 by Kruskal-Wallis test with ...
There becomes a better download soil mechanics to encode your situation cyclophilin. With term, the image you think Is you to keep up a broad dating chip for the structures and clouds that you represent to chop in your web on this problem. fighter thinking to make the Measure that you most rendezvous forward from across this bank into one 6-fold team, bulging you greater article over how you have with your NVA.
Fingerprint Dive into the research topics of Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain. Together they form a unique fingerprint. ...
Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a ... Horowitz DS, Lee EJ, Mabon SA, Misteli T (Feb 2002). "A cyclophilin functions in pre-mRNA splicing". The EMBO Journal. 21 (3): ... a nuclear cyclophilin" (PDF). The Journal of Biological Chemistry. 275 (11): 7439-42. doi:10.1074/jbc.275.11.7439. PMID ... "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". Journal of Molecular ...
Ferreira PA, Nakayama TA, Pak WL, Travis GH (Oct 1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green ... Ferreira PA, Yunfei C, Schick D, Roepman R (Sep 1998). "The cyclophilin-like domain mediates the association of Ran-binding ... Yi H, Friedman JL, Ferreira PA (Nov 2007). "The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the ... Ferreira PA, Hom JT, Pak WL (Sep 1995). "Retina-specifically expressed novel subtypes of bovine cyclophilin". The Journal of ...
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ... 2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866-71. doi: ... "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2". Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). " ... 2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLoS Biol. ...
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide ... Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the ... "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high ... cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3-4): 231-6. doi:10.1159/000056909 ...
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved ... "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical ... expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. ...
Examples include photoisomerase and immunophilins such as cyclophilin. cis-trans-Isomerases at the US National Library of ...
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, ... "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4". Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, ... structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell ...
It inhibits cyclophilin A. Alisporivir is not immunosuppressive. It is being researched for potential use in the treatment of ... Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of, and ... April 2008). "Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin ... December 2008). "Debio 025, a cyclophilin binding molecule, is highly efficient in clearing HCV replicon containing cells, ...
Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ... Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by ... Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in ...
As a cyclophilin, PPIB binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene ... Mikol V, Kallen J, Walkinshaw MD (1994). "X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A ... As a cyclophilin, PPIB binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. PPIB is the ...
As a cyclophilin, PPIC binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Depletion of these two cyclophilins lead to hyperoxidation of the ER. In the brain, PPIC complexes with cyclophilin C- ... Like other cyclophilins, PPIC forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ...
As a cyclophilin, PPIF binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Like other cyclophilins, PPIF forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a ...
As a cyclophilin, PPID binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on ... Like other cyclophilins, PPID forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ...
As a cyclophilin, PPIE also binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on ... Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, Sun L, Gao GF, Ye X, Liu W (2011). "Cyclophilin E functions as a negative ...
Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin ...
... which binds cyclophilin. Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called ... Along with cyclophilin, FKBPs belong to the immunophilin family. FKBP12 is notable in humans for binding the immunosuppressant ... FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins ... Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ...
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR ... Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (Jan 1997). "RS cyclophilins: identification of an NK-TR1-related ... "Entrez Gene: PPIG peptidylprolyl isomerase G (cyclophilin G)". Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (Aug 2004). " ... 2004). "The human nuclear SRcyp is a cell cycle-regulated cyclophilin". J. Biol. Chem. 279 (21): 22322-30. doi:10.1074/jbc. ...
When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein ... Bram RJ, Crabtree GR (1994). "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein". Nature. 371 (6495 ... Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ (2000). "Calcium-modulating cyclophilin ligand desensitizes hormone-evoked ... Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of ...
The Role of Cyclophilin D in learning and memory. Brush, F. Robert (2003). "Selection for Differences in avoidance Learning: ...
To the end of this, necrosis occurs by physical interaction with the PTP regulator cyclophilin D (CypD). The mitochondrial p53- ... Alam, M.R.; D. Baetz; M. Ovize (2015). "Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective". J Mol ...
CsA binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, which can ... It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases ... This cyclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of ... Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding ...
... is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B ... Yurchenko V, O'Connor M, Dai W, Guo H, Toole B, Sherry B, Bukrinsky M (2001). "CD147 is a signaling receptor for cyclophilin B ... 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". J. Biol. Chem. 277 (25): 22959 ... 2001). "CD147 is a signaling receptor for cyclophilin B". Biochem. Biophys. Res. Commun. 288 (4): 786-8. doi:10.1006/bbrc. ...
... cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair was ... The bumped cyclosporin A was found to interact efficiently with the hole-modified cyclophilin mutant, but not endogenous ... cyclophilin. The orthogonal CID pair was used to inhibit calcineurin-mediated dephosphorylation of nuclear factor of activated ... engineered to improve the binding efficiency between wild type cyclosporin A and cyclophilin, thereby giving more efficient CID ...
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
Examples comprise fibronectin/long chain cytokines, NEF/SH2, cyclophilin/capsid proteins. Ecology portal McGhee, G.R. (2011) ...
2009). "Methods for detecting a cyclophilin B SNP associated with HERDA". Retrieved September 2, 2016. CS1 maint: discouraged ... "Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the ...
Yang WM, Inouye CJ, Seto E (Jun 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The ... a peptidylprolyl cis-trans isomerase distinct from cyclophilin". Proceedings of the National Academy of Sciences of the United ...
Yang WM, Inouye CJ, Seto E (June 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". ...
2009). "Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury". Journal of Neuroscience. 29 (8): ...
However, Cyclophilin A is important for the inhibition of HIV-1 by TRIM5α in Old World monkey species. The "specificity" of ... Berthoux L, Sebastian S, Sokolskaja E, Luban J (2005). "Cyclophilin A is required for TRIM5α-mediated resistance to HIV-1 in ... Sayah DM, Sokolskaja E, Berthoux L, Luban J (2004). "Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance ...
Rotamase The first cyclophilin (Cyp/PPIases: EC 5.2.1.8) was isolated more than three decades ago as an... ... Cyclophilin-like domain (CLD); Immunophilin; Peptidyl prolyl cis trans isomerase; PPIase; ... The single domain cyclophilin has a single cyclophilin-like domain (CLD), whereas multidomain cyclophilins also possess ... Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009;284:9692-9.CrossRefPubMedPubMedCentral ...
Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a calcium/ ... Cyclophilin A is a cytosolic and highly abundant protein. The protein belongs to a family of isozymes, including cyclophilins B ... Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is ... Cyclophilin inhibitors, such as cyclosporin, are being developed to treat neurodegenerative diseases. Cyclophilin inhibition ...
The authors suggest that cyclophilin A (CypA), a component of the APOE4-activated pathway, is a potential target for treating ... Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that ... Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24, 1186-1191 ( ... Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nature Med. 15 ...
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL1-(4-Aminobenzyl)-3-(2-{(2r)-2-[2-(Methylsulfanyl)phenyl]pyrrolidin-1-Yl}-2-Oxoethyl)urea
cyclophilin-like protein. A. 196. Plasmodium yoelii. Mutation(s): 0 EC: 5.2.1.8. ...
cyclophilin. A. 229. Plasmodium yoelii yoelii. Mutation(s): 0 Gene Names: PY00382. EC: 5.2.1.8. ...
Mouse monoclonal Cyclophilin A antibody. Validated in WB, IP, Flow Cyt, ICC/IF and tested in Human. Cited in 14 publication(s ... Cyclophilin A was immunoprecipitated using 0.5mg Hela whole cell extract, 10µg of Mouse monoclonal to Cyclophilin A and 50µl of ... Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.. Contains 1 PPIase cyclophilin-type domain. ... Primary - Mouse Anti-Cyclophilin A antibody (ab58144) WB, ICC/IF, IP, Flow Cyt ...
Rabbit polyclonal Cyclophilin B antibody. Validated in WB, IP, IHC, ICC/IF and tested in Mouse, Rat, Horse, Chicken, Dog, Human ... Human Cyclophilin B peptide (ab16277) at 1 µg/ml. Lane 7 : HeLa whole cell lysate with Human Cyclophilin B peptide (ab16277) at ... Human Cyclophilin B peptide (ab16277) at 1 µg/ml. Lane 9 : Jurkat whole cell lysate with Human Cyclophilin B peptide (ab16277) ... Anti-Cyclophilin B antibody (ab16045) at 0.5 µg/ml + Recombinant Human Cyclophilin B protein (ab88801) at 0.01 µg. Secondary. ...
4 May 2017, by Kathrin Oppermann. The department of Molecular Plant Genetics has published a new research article: "Bioinformatic and expression analysis of the Brassica napus L. cyclophilins" in "Scientific Reports".. The full text article can be found here. ...
There are no specific protocols for Recombinant human Cyclophilin F protein (ab79186). Please download our general protocols ...
Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant ... Humans are thought to have around 16 of these cyclophilins.. Cyclophilin Function. The Cyclosporin Cyclophilin A complex ... About Cyclophilin:. Cyclophilins are known for their ability to bind ciclosporin, which is used to suppress rejection after a ... Cyclophilin Structure. Cyclophilin A has a beta barrel structure (two alpha helices and a beta sheet). There is usually a ...
... mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA ...
Browse our Cyclophilin C Antibody catalog backed by our Guarantee+. ... Our Cyclophilin C Antibodies can be used in a variety of model species: Human. Use the list below to choose the Cyclophilin C ... Alternate Names for Cyclophilin C Antibodies. anti-Cyclophilin C antibody, anti-PPIC antibody, anti-CYPCMGC3673 antibody, anti- ... Cyclophilin C Antibodies. We offer Cyclophilin C Antibodies for use in common research applications: ELISA, ...
... cyclophilin a include A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype ... Cyclophilin A: A 17-KDa cytoplasmic Peptidylprolyl isomerase involved in immunoregulation. It is a member of the cyclophilin ...
Generation of Rabbit Anti-Cyclophilin and Anti-AGE-Modified Cyclophilin Antisera.. Female New Zealand white rabbits were ... cyclophilin A;. CsA,. cyclosporin A;. PIC,. pre-integration complex;. CA,. capsid antigen;. AGE,. advanced glycosylation ... and 100 nmol of 125I-cyclophilin (either alone, or in combination with a 100-fold excess of cold cyclophilin) was added. After ... A receptor for another member of the cyclophilin family, cyclophilin B (CyPB), which is highly homologous to CyPA, has been ...
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.. Zhu D1, Wang Z2, Zhao JJ1, ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ...
HIV-1 cyclophilin-binding mutants CA G89V and P90A favored integration in genomic regions with a higher density of ... HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency PLoS ... Here we report that HIV-1 capsid (CA) binds directly to the cyclophilin domain of Nup358/RanBP2. Fusion of the Nup358/RanBP2 ... Our findings link HIV-1 engagement of cyclophilins with both integration targeting and replication efficiency and provide ...
Cyclophilin A is a peptidyl-prolyl isomerase and is widely expressed in a multitude of tissues, but is present in highest ... Cyclophilin A is a small, soluble protein which binds the immunosuppressive drug cyclosporin A. ... The pattern of cyclophilin. A expression is consistent with a role of cyclophilin A in neuronal protein maturation and folding ... Cyclophilin A is a small, soluble protein which binds the immunosuppressive drug cyclosporin A. Cyclophilin A is a peptidyl- ...
13 antibodies to Cyclophilin A and validated for use in 6 applications (Immunohistochemistry,Flow Cytometry,Western Blot, ... cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p ... cyclophilin A); PPIase A; rotamase; Rotamase A; SP18; T cell cyclophilin ... Cyclophilin A Antibodies Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major ...
Validated positive control siRNA targeting the Cyclophilin B (PPIB) housekeeping gene in human, mouse, or rat Accell siRNA ... Accell Cyclophilin B Control siRNA Accell Cyclophilin B Control siRNA. Validated Accell positive controls provide a reliable ... Accell Cyclophilin B Control siRNA is modified with patent-pending Accell modification pattern to enable uptake by difficult-to ... Accell Cyclophilin B Control siRNA is validated, highly reliable positive control for delivery and RNAi efficiency. ...
Cyclophilin D (CypD), as the only crucial protein for mitochondrial permeability transition pore (mPTP) induction, facilitates ... Blockade of Cyclophilin D Attenuates Oxidative Stress-Induced Cell Death in Human Dental Pulp Cells,. Oxidative Medicine and ... C. P. Baines, R. A. Kaiser, N. H. Purcell et al., "Loss of cyclophilin D reveals a critical role for mitochondrial permeability ... Cyclophilin D (CypD), as the only crucial protein for mitochondrial permeability transition pore (mPTP) induction, facilitates ...
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. ... Keywords: influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction influenza virus; Cyclophilin A; Cyclosporin A; ... This article belongs to the Special Issue Cyclophilins and Viruses) View Full-Text , Download PDF [274 KB, uploaded 12 May 2015 ... Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. ...
This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition ...
Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the ... Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore. J. ... Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex. J. Biol. Chem. ... The prolyl isomerase cyclophilin D (CypD) in the matrix is an important regulator of mPTP opening10,11. CypD was identified as ...
A Cyclophilin Function in Hsp90-Dependent Signal Transduction. By Andrea A. Duina, Hui-Chen Jane Chang, James A. Marsh, Susan ... A Cyclophilin Function in Hsp90-Dependent Signal Transduction. By Andrea A. Duina, Hui-Chen Jane Chang, James A. Marsh, Susan ... A Cyclophilin Function in Hsp90-Dependent Signal Transduction Message Subject. (Your Name) has forwarded a page to you from ... Cpr6 and Cpr7, the Saccharomyces cerevisiae homologs of cyclophilin-40 (CyP-40), were shown to form complexes with Hsp90, a ...
Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding, R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding, R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding and R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues. Message Subject (Your Name) has forwarded a ...
Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin. By Gitta Coaker, Arnold Falick, Brian ... Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin. By Gitta Coaker, Arnold Falick, Brian ... AvrRpt2 is delivered into the plant cell, where it is activated by a eukaryotic factor that we identify as cyclophilin. This ... Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin Message Subject. (Your Name) has ...
Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an ... Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an ...
These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER ... cyclophilin B , peptidylprolyl isomerase B , peptidylprolyl isomerase B (cyclophilin B) , PPIase B , peptidyl-prolyl cis-trans ... anti-Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G Antikörper * anti-Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A ... Zusätzlich bieten wir Ihnen Peptidylprolyl Isomerase B (Cyclophilin B) Kits (62) und Peptidylprolyl Isomerase B (Cyclophilin B ...
Buy cyclophilin g antibodies from Santa Cruz Biotechnology, Inc. Monoclonal antibodies are available to most protein immunogens ... Additional Cyclophilin Antibodies including Cyclophilin E, Cyclophilin F, CyPA, CyPB and Cyclophilin 40 ... Cyclophilin G Antibodies. Santa Cruz Biotechnology, Inc. offers a broad range of Cyclophilin G antibodies. Select Cyclophilin G ... View detailed Cyclophilin G antibody specifications by linking to the specific product blocks. Select appropriate Cyclophilin G ...
  • Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of APOE4 and lack of murine Apoe, but not APOE2 and APOE3, leads to BBB breakdown by activating a proinflammatory CypA-nuclear factor-κB-matrix-metalloproteinase-9 pathway in pericytes. (nature.com)
  • More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated into HIV-1 virions and its incorporation essential for viral infectivity. (pnas.org)
  • The finding that cyclophilin A (CyPA), a cellular protein that binds cyclosporin A (CsA) and possesses peptidyl-prolyl cis-trans isomerase activity ( 1 , 2 ), is specifically incorporated into HIV-1 virions through interactions with the Gag polyprotein ( 3 , 4 ) and is required for effective infection ( 5 - 8 ) raised a number of interesting questions about the biology of this phenomenon. (pnas.org)
  • Because cyclophilins can control protein folding by catalyzing peptidyl-prolyl isomerization ( 9 , 10 ), it has been proposed that CyPA may modify the conformation of capsid antigen (CA), a Gag polyprotein cleavage product that binds CyPA ( 11 ), thus promoting uncoating of the virion and formation of the pre-integration complex (PIC) ( 6 ). (pnas.org)
  • Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. (thermofisher.com)
  • CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells. (thermofisher.com)
  • Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. (mdpi.com)
  • New World monkeys of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infection. (sigmaaldrich.com)
  • Cyclophilin A (CyPA, encoded by Ppia) is a ubiquitously expressed protein secreted in response to pro-inflammatory stimuli. (ahajournals.org)
  • Moreover, en face staining of aortic tissues showed that VCAM-1 expression was significantly reduced in mice lacking CyPA. (ahajournals.org)
  • Cyclophilin A (CYPA) is the first member of the cyclophilins to be identified in mammals. (biovendor.com)
  • CypA (cyclophilin A) is a ubiquitous and highly conserved protein with peptidyl prolyl isomerase activity. (ahajournals.org)
  • Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that binds to the capsid protein (CA) of human immunodeficiency virus type 1 (HIV-1) and by doing so facilitates HIV-1 replication. (pubmedcentralcanada.ca)
  • Cyclophilin A (CypA) is the most abundant member of a ubiquitous family of peptidyl-prolyl isomerases and binds to the capsid (CA) domain of human immunodeficiency virus type 1 (HIV-1) and SIVcpz Gag proteins ( 26 ). (pubmedcentralcanada.ca)
  • OBJECTIVE Cyclophilin A (CyPA) is an abundant intracellular protein that is considered to be the main target of the immunosuppressive drug cyclosporine A. We and others showed that CyPA is secreted from smooth muscle cells and macrophages in response to oxidative stress and lipopolysaccharide, suggesting a role for CyPA in inflammation. (semanticscholar.org)
  • Viral incorporation of cyclophilin A (CyPA) during the assembly of human immunodeficiency virus type-1 (HIV-1) is crucial for efficient viral replication. (uzh.ch)
  • Peptides corresponding to these regions showed higher affinities (Kd approximately 0.3 microM) for both CyPA and cyclophilin B than the best peptide derived from the Gly-Pro90 site ( approximately 8 microM) and thus revealed new sequence motifs flanking Gly-Pro that are important for tight interaction of peptide ligands with cyclophilins. (uzh.ch)
  • Consequently, CyPA and cyclophilin B bound with much higher affinities ( approximately 0.6 and 0.25 microM) to the new, i.e. maturation-generated sites. (uzh.ch)
  • The capsid (CA) protein of HIV-1 binds with high affinity to the host protein cyclophilin A (CypA). (biomedcentral.com)
  • This binding positively affects some early stage of the viral life-cycle because prevention of binding either by drugs that occupy that active site of cyclophilin A, by mutation in HIV-1 CA, or RNAi that knocks down intracellular CypA level diminishes viral infectivity. (biomedcentral.com)
  • Cyclophilin A (CyPA) is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. (readbyqxmd.com)
  • 2005). Furthermore, it has been shown that severe acute respiratory syndrome (SARS)-N protein interacts with cellular proteins, including cyclophilin A (CypA), heterogenous nuclear ribonucleoprotein (hnRNP) A1, human ubiquitin-conjugating enzyme, cyclin dependent kinase (CDK)-cyclin complex protein, Ikappaßalpha (IkBα), cytochrome (Cyt) P450 etc. (uwc.ac.za)
  • Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. (sinobiological.com)
  • The H87Q mutation is located in the cyclophilin A (CypA) binding loop and has a prevalence of 21% in HIV-1 sequences registered in HIV database. (biomedcentral.com)
  • BACKGROUND: The human peptidyl-prolyl isomerase Cyclophilin A (CypA) binds HIV-1 capsid (CA) and influences early steps in the HIV-1 replication cycle. (umassmed.edu)
  • Three independent studies recently demonstrated that HCV highly relies on cyclophilin A (CypA) to replicate in human hepatocytes. (grantome.com)
  • In this study, we found that expression of cyclophilin A (CypA) was significantly upregulated in Spodoptera litura hemocytes at 6‐day post‐parasitization. (usda.gov)
  • Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. (springer.com)
  • The cytosolic concentration, Mr, and isoforms of cyclophilin (CyP), a specific cytosolic binding protein for cyclosporin A (CsA), were determined in normal and neoplastic human tissues as well as tissues from species of diverse phylogeny. (jimmunol.org)
  • Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. (prospecbio.com)
  • Two other novel findings arose in the course of the study, namely a 54 kD proline-rich cyclophilin D binding protein (identified by pull-downs and mass spectrometry) and phosphorylation of a (non- identified) 17 kD protein in cyclophilin D overexpressing mitochondria. (ucl.ac.uk)
  • Cyclophilin B (CyPB) is a cyclosporin A (CsA)binding protein mainly located in intracellular vesicles and secreted in biological fluids. (cnrs-orleans.fr)
  • The two classical immunophilin families, found essentially in all living cells, are: cyclophilin (CYN) and FK506-binding protein (FKBP). (usda.gov)
  • Cyclophilins comprise a ubiquitous set of proteins which is present across diverse genera of organisms. (springer.com)
  • Cyclophilins (CYPs) are a family of proteins named after their ability to bind to ciclosporin (cyclosporin A), an immunosuppressant which is usually used to suppress rejection after internal organ transplants. (wikipedia.org)
  • Cyclophilins have peptidyl-prolyl cis-trans isomerase activity, and these proteins are collectively known as immunophilins. (prospecbio.com)
  • It is a member of the cyclophilin family of proteins that binds to Cyclosporine . (jove.com)
  • Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. (pnas.org)
  • Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). (thermofisher.com)
  • Additionally we are shipping Peptidylprolyl Isomerase B (Cyclophilin B) Antibodies (152) and Peptidylprolyl Isomerase B (Cyclophilin B) Proteins (31) and many more products for this protein. (antibodies-online.com)
  • Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. (sigmaaldrich.com)
  • and structural proteins ( cyclophilin , actin, and chitinase). (thefreedictionary.com)
  • Human have a total of 16 cyclophilin proteins. (biovendor.com)
  • It was first identified in a yeast two-hybrid screen for cyclophilin B-interacting proteins ( 9 ). (jimmunol.org)
  • Cyclophilins are ubiquitous cellular proteins with peptidyl-prolyl cis-trans isomerase enzymatic activity, which are involved in a variety of functions related to cell metabolism, energy homeostasis, and exhibit enhanced expression in inflammation or malignancy. (biovendor.com)
  • The role of cyclophilins, heat shock proteins (HSP), and the mitochondrial chaperone complex (MCC), was studied in this pathological condition. (bl.uk)
  • The three PPIase subfamilies, cyclophilins, FKBPs (FK506 binding proteins) and parvulins form a group by their enzymatic activity despite lack of sequence similarity between the subfamilies. (diva-portal.org)
  • Cyclophilins play roles in folding and chaperoning of cellular proteins and are the major receptors for the immunosuppressive drug cyclosporin A (CsA). (tcd.ie)
  • We, and others, have previously characterized two CsA-binding cyclophilins (PfCYP19A and PfCYP19B) but a family of genes encoding uncharacterized cyclophilins/cyclophilin-like proteins is also seen in the P. falciparum genome (Figure 1). (tcd.ie)
  • Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. (sinobiological.com)
  • PPIA / Cyclophilin A accelerate the folding of proteins. (sinobiological.com)
  • PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. (sinobiological.com)
  • Proteins with prolyl isomerase activity include cyclophilins, FKBPs, and parvulin. (cambridgemedchemconsulting.com)
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Mouse Anti Human Cyclophilin-B Cyclophilin-B. (antibody-antibodies.com)
  • Cyclophilin D (CypD), as the only crucial protein for mitochondrial permeability transition pore (mPTP) induction, facilitates the opening of mPTP and causes mitochondrial dysfunction, leading to cell death. (hindawi.com)
  • This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. (go.jp)
  • Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies. (nature.com)
  • Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a potential role in bioenergetics is not understood. (lu.se)
  • Opening of the pore is regulated by the mitochondrial peptidyl prolyl-cis, trans-isomerase cyclophilin D (CYPD). (frontiersin.org)
  • Here, we show that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator, results in increased cell proliferation and enhanced cell migration and invasion. (lu.se)
  • The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. (ovid.com)
  • Cyclosporin A (CsA) inhibits the opening of the mitochondrial permeability transition pore (MPTP) by interacting with cyclophilin D (CypD) and ameliorates neuronal cell death in the central nervous system against ischemic injury. (arvojournals.org)
  • Under these conditions, mitochondrially-localized STAT3 also became competent to bind to cyclophilin D (CypD). (nottingham.ac.uk)
  • RATIONALE: Mice lacking cyclophilin D (CypD), a mitochondrial chaperone protein, have altered cardiac metabolism. (elsevier.com)
  • Cyclophilin D (CypD) is an important component in mitochondrial-dependent tubular cell death in acute kidney injury. (monash.edu)
  • Each Cyclophilin C Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Cyclophilin C polyclonal antibodies and browse our Cyclophilin C monoclonal antibody catalog. (novusbio.com)
  • Fluorescent double-labelling experiments on hippocampal cell cultures revealed that all cells labelled with the cyclophilin A antibody also showed staining for the neuron-specific marker for microtubule-associated protein (MAP)2, and could, therefore, be identified as neurons. (nih.gov)
  • View detailed Cyclophilin G antibody specifications by linking to the specific product blocks. (scbt.com)
  • There are currently no images for Cyclophilin C Antibody (NBP1-97946AF700). (novusbio.com)
  • Western Blot (WB) analysis of 1) Jurkat, 2)293T, 3)Rat Liver Tissue, 4)3T3 with Cyclophilin B Mouse Monoclonal Antibody diluted at 1:2000. (genetex.com)
  • Cyclophilin D antibody LS-C163901 is an unconjugated rabbit polyclonal antibody to Cyclophilin D (PPID) (aa85-115) from human. (lsbio.com)
  • Mouse Anti Human Cyclophilin-B Cyclophilin-B antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Mouse Anti Human Cyclophilin-B Cyclophilin-B. (antibody-antibodies.com)
  • Recombinant full length protein corresponding to Human Cyclophilin A aa 1-165. (abcam.com)
  • Cyclophilin B Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids (34-216 a.a) and having a molecular mass of 22.7kDa. (prospecbio.com)
  • Full length, recombinant human Cyclophilin 40 expressed in E. coli. (genetex.com)
  • Recombinant human cyclophilin B was expressed in E. coli and purified by using conventional chromatography techniques. (antibodies-online.com)
  • However neither cyclophilin D (overexpression) nor cyclophilin A (addition of recombinant enzyme) stimulated cytochrome c release. (ucl.ac.uk)
  • Validated positive control siRNA targeting the Cyclophilin B (PPIB) housekeeping gene in human, mouse, or rat. (horizondiscovery.com)
  • Also known as peptidylprolyl isomerase B (PPIB), cyclophilin B is abundantly expressed in most mammalian cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. (horizondiscovery.com)
  • A missense mutation in cyclophilin B (PPIB) is reported as a novel, causal candidate gene for hereditary equine regional dermal asthenia (HERDA). (antikoerper-online.de)
  • LS-F43019 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Chicken PPIB / Cyclophilin B. It is based upon a Custom assay principle and can be used to detect levels of PPIB / Cyclophilin B as low as 18.75 nanograms per millilter. (lsbio.com)
  • The Staphylococcus aureus cyclophilin PpiB is an intracellular peptidyl prolyl cis/trans isomerase (PPIase) that has previously been shown to contribute to secreted nuclease and hemolytic activity. (asm.org)
  • PpiB is a functional PPIase belonging to the cyclophilin family, and it assists in the refolding of Nuc in vitro . (asm.org)
  • A validated positive silencing control targeting the Cyclophilin B (PPIB) gene in human, mouse, or rat cell lines. (gelifesciences.com)
  • Also known as peptidylprolyl isomerase B (PPIB), cyclophilin B is associated with the secretory pathway. (gelifesciences.com)
  • Gentaur Molecular :Fivephoton \ Mouse Cyclophilin B (CYPB, PPIB, Peptidylprolyl Isomerase B) ELISA KITS. (antibody-antibodies.com)
  • Product Detail : mCYPB-ELISA(2X96T) Mouse Cyclophilin B (CYPB, PPIB, Peptidylprolyl Isomerase B) ELISA KITS. (antibody-antibodies.com)
  • This is mostly due to the stabilyty of the standard of the Mouse Cyclophilin B (CYPB, PPIB, Peptidylprolyl Isomerase B) ELISA KITS. (antibody-antibodies.com)
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  • Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a calcium/calmodulin-dependent phosphatase, calcineurin, the inhibition of which is thought to suppress organ rejection by halting the production of the pro-inflammatory molecules TNF alpha and interleukin 2. (wikipedia.org)
  • Cyclophilin D is thought to regulate the opening of the pore because cyclosporin A, which binds to CyP-D, inhibits the pore opening. (wikipedia.org)
  • Cyclophilin inhibitors, such as cyclosporin, are being developed to treat neurodegenerative diseases. (wikipedia.org)
  • Cyclophilin A is a small, soluble protein which binds the immunosuppressive drug cyclosporin A. Cyclophilin A is a peptidyl-prolyl isomerase and is widely expressed in a multitude of tissues, but is present in highest concentration in the brain. (nih.gov)
  • TLP20 was inhibited by cyclosporin A and mass spectrometric sequencing of tryptic peptides confirmed its classification as a cyclophilin. (diva-portal.org)
  • Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. (emdmillipore.com)
  • Cyclophilin is characterized by its binding to the immunosuppressant cyclosporin A. This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity. (emdmillipore.com)
  • Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). (apsnet.org)
  • Zusätzlich bieten wir Ihnen Peptidylprolyl Isomerase B (Cyclophilin B) Kits (62) und Peptidylprolyl Isomerase B (Cyclophilin B) Proteine (31) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Cyclophilin is the trivial name for peptidylprolyl isomerase, EC 5.2.1.8 (peptidylproline cis-trans-isomerase). (thefreedictionary.com)
  • Full length Clone DNA of Rat peptidylprolyl isomerase A (cyclophilin A) with N terminal HA tag. (sinobiological.com)
  • Cyclophilin D (CYP D), is a member of a family of highly homologous peptidylprolyl cis-trans isomerases (PPIases) that interconvert the cis and trans isomers of peptide bonds with the amino acid proline. (cambridgemedchemconsulting.com)
  • De plus, nous expédions Peptidylprolyl Isomerase E (Cyclophilin E) Protéines (24) et beaucoup plus de produits pour cette protéine. (anticorps-enligne.fr)
  • Simon Kerr, chief executive officer, Cypralis, said, "Cyprolides are a new class of fully synthetic cyclophilin inhibitors that are potent inhibitors of cyclophilin D and protect against opening of the mitochondrial permeability transition pore. (thefreedictionary.com)
  • Cyclophilin D inhibitors for treating human conditions such as ischemia/reperfusion injury, trauma and neurodegenerative diseases. (thefreedictionary.com)
  • This study shows that the company's cyclophilin inhibitors can be further developed towards the goal of offering mitochondrial myopathy patients a novel treatment option. (thefreedictionary.com)
  • Inhibitors of Cyclophilin D have been postulated as potential drugs for a variety of therapeutic targets including anti-viral activity DOI , neurodegenration DOI , Cancer DOI etc. (cambridgemedchemconsulting.com)
  • At the recent Macrocycles 2018 meeting Vicky Steadman described the identification and optimisation of potent and orally available selective Cyclophilin inhibitors, more details have just been published J Med Chem paper DOI . (cambridgemedchemconsulting.com)
  • A growing body of evidence suggests that cyclophilins (Cyps) are important for the HCV life cycle, suggesting that Cyp inhibitors (CsA, Debio 025, NIM811 or SCY- 635), by acting on intracellular Cyps, block HCV replication. (grantome.com)
  • By demonstrating that cyclophilin (Cyp) inhibitors have potent efficacy against HCV, our recent clinical study opens a new line of opportunity to eradicate this prime human threat. (grantome.com)
  • This review describes the cyclophilin protein family and the potential roles played by cyclophilins in supporting HCV RNA replication and protein expression, as well as the initial clinical results obtained with a novel series of non-immunosuppressive cyclophilin inhibitors that established the clinical proof of concept for this emerging class of therapeutic agents. (scripps.edu)
  • We offer Cyclophilin C Antibodies for use in common research applications: ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot. (novusbio.com)
  • Our Cyclophilin C Antibodies can be used in a variety of model species: Human. (novusbio.com)
  • Santa Cruz Biotechnology, Inc. offers a broad range of Cyclophilin G antibodies. (scbt.com)
  • Select Cyclophilin G antibodies from monoclonal antibodies listed below. (scbt.com)
  • Select appropriate Cyclophilin G antibodies for your research by isotype, epitope, applications and species reactivity. (scbt.com)
  • Here we report that HIV-1 capsid (CA) binds directly to the cyclophilin domain of Nup358/RanBP2. (nih.gov)
  • Coimmunoprecipitation and intracellular binding studies suggested that LKT binds to the mitochondrial matrix protein cyclophilin D. We also demonstrated that LKT mobilizes the vesicle scission protein dynamin-2 from mitochondria to the cell membrane. (asm.org)
  • Cyclophilin inhibition may also be a therapy for liver diseases. (wikipedia.org)
  • Belongs to the cyclophilin-type PPIase family. (abcam.com)
  • Contains 1 PPIase cyclophilin-type domain. (abcam.com)
  • The most active PPIase in the spinach lumen was identified as the cyclophilin TLP20. (diva-portal.org)
  • Genes encoding similar putative thylakoid cyclophilins with a unique insert of three amino acids NPV in their N-termini were found in chromosome 5 of both Arabidopsis and rice. (diva-portal.org)
  • Cyclophilin A is a cytosolic and highly abundant protein. (wikipedia.org)
  • As potential targets of CSA, the isolated mitochondria contained both cyclophilin D (mitochondrial matrix) and residual cyclophilin A (a cytosolic enzyme). (ucl.ac.uk)
  • Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A. Proc Natl Acad Sci USA. (springer.com)
  • The cellular peptidyl-prolyl isomerase cyclophilin A is incorporated into human immunodeficiency virus type 1 virions via contacts with the proline-rich domain of the Gag polyprotein. (asm.org)
  • An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. (antikoerper-online.de)
  • Notably, treatment with antioxidants rescues mitochondrial damage markers in fibroblasts from patients with X-linked adrenoleukodystrophy, including cyclophilin D oxidative modifications, and reverses cyclophilin D induction in vitro and in vivo. (sigmaaldrich.com)
  • Ray, Rialon-Guevara, Veras, Sullenger, White: Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. (antibodies-online.com)
  • Neither mutation alters Gag's cyclophilin A-binding properties in vitro, and cyclophilin A incorporation into drug-resistant virions is effectively disrupted by cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophilin A to initiate infection. (asm.org)
  • Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin" (PDF). (wikipedia.org)
  • The first cyclophilin (Cyp/PPIases: EC 5.2.1.8) was isolated more than three decades ago as an intracellular receptor of the immunosuppressive drug cyclosporine A (CsA) from the bovine thymocyctes (Handschumacher et al. (springer.com)
  • Cyclophilins also have varying degrees of affinity for the immunosuppressive drug Cyclosporine A (CsA), a cyclic 11-amino-acid peptide produced by fungus Tolypocladium infantum. (biovendor.com)
  • Cyclophilins and FKBPs, collectively called immunophilins, were originally discovered as the targets of the immunosuppressive drugs cyclosporine A and FK506, respectively. (diva-portal.org)
  • Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A. (asm.org)
  • That Gag's functional dependence on cyclophilin A can be differentiated genetically from its ability to bind cyclophilin A is further demonstrated by the rescue of a mutation precluding cyclophilin A packaging by a mutation conferring cyclosporine A resistance. (asm.org)
  • The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. (nih.gov)
  • The isomerase active site of cyclophilin a is critical for hepatitis C virus replication. (thefreedictionary.com)
  • Structurally, CypB shows a high degree of homology with other members of the cyclophilin family in its core β-barrel/isomerase region, which contains a surface hydrophobic pocket that constitutes the proline binding motif. (biovendor.com)
  • Cyclophilins (Cyp) are a family of cellular enzymes possessing peptidyl-prolyl isomerase activity which catalyze the cis-trans interconversion of proline-containing peptide bonds. (auburn.edu)
  • Cyclophilins (Cyps) constitute one of the three families of peptidyl prolyl isomerase enzymes. (scripps.edu)
  • Data indicate that the mutation in cyclophilin B (CypB) locally rearranges the flexible N-terminal end of the polypeptide chain and also makes it more rigid. (antikoerper-online.de)
  • Both N- and C- termini of CypB differ significantly from other cyclophilin family members. (biovendor.com)
  • Contrasting effects of electroconvulsive shock on mRNAs encoding the high affinity kainate receptor subunits (KA1 and KA2) and cyclophilin in the rat. (ox.ac.uk)
  • Cyclophilin A is also known to be recruited by the Gag polyprotein during HIV-1 virus infection, and its incorporation into new virus particles is essential for HIV-1 infectivity. (wikipedia.org)
  • in parallel with the disruption of cyclophilin A incorporation into virions, there is a linear reduction in the initiation of reverse transcription after infection of a T cell. (asm.org)
  • donovanichaperone cyclophilin 40 (LdCyP40) for infection. (ovid.com)
  • Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. (tcd.ie)
  • Accell Cyclophilin B Control siRNA is validated, highly reliable positive control for delivery and RNAi efficiency. (horizondiscovery.com)
  • Accell Cyclophilin B Control siRNA is modified with patent-pending Accell modification pattern to enable uptake by difficult-to-transfect cells. (horizondiscovery.com)
  • siGENOME Cyclophilin B Control siRNA is a validated positive control, guaranteed to silence cyclophilin B in human, mouse, or rat cells. (gelifesciences.com)
  • siSTABLE Non-Targeting siRNA #1 (D-001700-01, Lanes 1 and 4), siGENOME Cyclophilin B siRNA (D-001136-01, Lanes 2 and 5), and siSTABLE Cyclophilin B siRNA (D-001710-02, Lanes 3 and 6). (horizondiscovery.com)
  • Cyclophilin-A HumanRecombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 185 amino acids (1-165 a.a.) and having a molecular mass of 20 kDa. (neobiolab.com)
  • Recombiant, human cyclophilin A expressed in E. coli . (emdmillipore.com)
  • Our findings link HIV-1 engagement of cyclophilins with both integration targeting and replication efficiency and provide insight into the conservation of viral cyclophilin recruitment. (nih.gov)
  • Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral Therapy. (semanticscholar.org)
  • De Iaco, Alberto and Luban, Jeremy, "Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA" (2014). (umassmed.edu)
  • Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. (springer.com)
  • Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is located in the matrix of mitochondria, is only a modulatory, but may or may not be a structural component of the mitochondrial permeability transition pore. (wikipedia.org)
  • However, mitochondria obtained from the cysts of Artemia franciscana, do not exhibit the mitochondrial permeability transition pore Overexpression of Cyclophilin A has been linked to poor response to inflammatory diseases, the progression or metastasis of cancer, and aging. (wikipedia.org)
  • Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D". J. Biol. (wikipedia.org)
  • Among the mitochondrial permeability transition pore components, cyclophilin D is the most studied and has been found increased under pathological conditions. (sigmaaldrich.com)
  • However, using mitochondrially entrapped fluorophores and agents that promote the transition (Ca2+, overexpression of mitochondrial cyclophilin D), BID-induced cytochrome c release was in fact found to be independent of permeability transition. (ucl.ac.uk)
  • Nevertheless, CSA, a potent inhibitor of cyclophilins and the permeability transition, did inhibit cytochrome c release. (ucl.ac.uk)
  • This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. (acris-antibodies.com)
  • A expression is consistent with a role of cyclophilin A in neuronal protein maturation and folding in vivo. (nih.gov)
  • Moreover, we show increased expression levels of cyclophilin D in the affected zones of brains in patients with adrenomyeloneuropathy, in spinal cord of a mouse model of X-linked adrenoleukodystrophy (Abcd1-null mice) and in fibroblasts from patients with X-linked adrenoleukodystrophy. (sigmaaldrich.com)
  • We also measured the expression of cyclophilin mRNA, and found it to be reduced in all hippocampal subfields, and in the parietal cortex, after a single ECS. (ox.ac.uk)
  • Synthetic peptide conjugated to KLH derived from within residues 150 to the C-terminus of Human Cyclophilin B. (abcam.com)
  • Detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).Can be blocked with Human Cyclophilin B peptide (ab16277) . (abcam.com)
  • Cyclophilins are known for their ability to bind ciclosporin, which is used to suppress rejection after a human has an internal organ transplant. (prospecbio.com)
  • 1987), Complementary DNA for human T-cell cyclophilin. (sinobiological.com)
  • 1990), Characterization of the human cyclophilin gene and of related processed pseudogenes.Eur. (sinobiological.com)
  • Mouse Anti Human Cyclophilin-B Cyclophilin-B Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • A synthetic peptide corresponding to a sequence at the C-terminus of human Cyclophilin B(176-196aa MEVVRKVESTKTDSRDKPLKD), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids. (bosterbio.com)
  • A new family of cyclophilins with an RNA recognition motif that interact with members of the trx (Montrer GSR Anticorps )/ MLL (Montrer MLL Anticorps ) protein family in Drosophila and human cells. (anticorps-enligne.fr)
  • Detects cyclophilin 40 (CyP 40) from Human and Rat tissues and cells. (abcam.co.jp)
  • Synthetic peptide corresponding to Human Cyclophilin 40 aa 356-370. (abcam.co.jp)
  • Cyclophilin A, in particular, is the major intracellular receptor for CsA. (biovendor.com)
  • In the respect that cyclophilin is regarded as a housekeeping gene, the reduction in its mRNA suggests that ECS may have more persistent and widespread effects on brain gene expression than previously suspected. (ox.ac.uk)
  • Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a K d of 5 nM, shows effective anti- HCV activity, with an EC 50 of 98 nM for HCV 2a. (medchemexpress.com)
  • Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. (medchemexpress.com)
  • Allain F, Vanpouille C, Carpentier M, Slomianny MC, Durieux S, Spik G. Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix. (springer.com)
  • Fusion of the Nup358/RanBP2 cyclophilin (Cyp) domain to the tripartite motif of TRIM5 created a novel inhibitor of HIV-1 replication, consistent with an interaction in vivo. (nih.gov)
  • Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix. (semanticscholar.org)
  • Moreover, DB25, a CSA analogue that inhibits the catalytic activity of both cyclophilins, but does not allow interaction with downstream targets such as calcineurin, was ineffective, and instead had a stimulatory effect on cytochrome c release. (ucl.ac.uk)
  • Here we report two new interaction sites between cyclophilins and p24. (uzh.ch)
  • 1Z81: Crystal Structure of cyclophilin from Plasmodium yoelii. (rcsb.org)
  • Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. (springer.com)
  • Cyclophilin B activity regulated secretion and activity of ADAMTS13 (show ADAMTS13 ELISA Kits ). (antibodies-online.com)
  • Cyclophilin inhibitor 1 (Compound 3) inhibits HCV 2a activity, with an EC 50 of 98 nM [1] . (medchemexpress.com)
  • PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. (sinobiological.com)
  • Cyclophilin eluted as a sharp peak with an apparent molecular mass of 19 kDa. (pnas.org)
  • Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (springer.com)
  • These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclophilin A. (asm.org)
  • Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy. (sigmaaldrich.com)