Cyclophilin A
Cyclophilins
Peptidylprolyl Isomerase
Amino Acid Isomerases
Cyclosporine
Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Cyclosporins
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Carrier Proteins
Antigens, CD147
Mitochondrial Membrane Transport Proteins
Transmembrane Activator and CAML Interactor Protein
Tacrolimus Binding Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Aotidae
Amino Acid Sequence
Calcineurin
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Tumor Necrosis Factor Ligand Superfamily Member 13
Protein Binding
HIV-1
Proline
Spiro Compounds
Subtilisin
Virus Replication
Sequence Homology, Amino Acid
B-Cell Maturation Antigen
Adenine Nucleotide Translocator 1
Tacrolimus
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Virion
Gene Products, gag
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
HSP90 Heat-Shock Proteins
Isomerism
Calmodulin-Binding Proteins
Models, Molecular
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
B-Cell Activating Factor
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
Membrane Potential, Mitochondrial
Base Sequence
Binding Sites
Molecular Chaperones
Luteoviridae
Cloning, Molecular
Cercopithecidae
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Mitochondrial Membranes
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).
Cyclophilin A is a secreted growth factor induced by oxidative stress. (1/314)
Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis, hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. Many VSMC growth factors are secreted by VSMC and act in an autocrine manner. Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Human recombinant CyPA can mimic the effects of secreted CyPA to stimulate ERK1/2 and cell growth. The peptidyl-prolyl isomerase activity is required for ERK1/2 activation by CyPA. In vivo, CyPA expression and secretion are increased by oxidative stress and vascular injury. These findings are the first to identify CyPA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases. (+info)Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (2/314)
The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. To determine whether CypA promotes HIV-1 replication, we deleted the gene encoding CypA (PPIA) in human CD4(+) T cells by homologous recombination. HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific for wild-type HIV-1 since HIV-2/SIV isolates, as well as HIV-1 bearing a gag mutation that confers cyclosporin resistance, replicated the same in PPIA(+/+) and PPIA(-/-) cells. Stable re-expression of CypA in PPIA(-/-) cells restored HIV-1 replication to an extent that correlated with steady-state levels of CypA. Finally, virions from PPIA(-/-) cells possessed no obvious biochemical abnormalities but were less infectious than virions from wild-type cells. These data formally demonstrate that CypA regulates the infectivity of HIV-1 virions. (+info)Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. (3/314)
Caveolin-1 is a palmitoylated protein involved in assembly of signaling molecules in plasma membrane subdomains termed caveolae and in intracellular cholesterol transport. Three cysteine residues in the C terminus of caveolin-1 are subject to palmitoylation, which is not necessary for caveolar targeting of caveolin-1. Protein palmitoylation is a post-translational and reversible modification that may be regulated and that in turn may regulate conformation, membrane association, protein-protein interactions, and intracellular localization of the target protein. We have undertaken a detailed analysis of [(3)H]palmitate incorporation into caveolin-1 in aortic endothelial cells. The linkage of palmitate to caveolin-1 was hydroxylamine-sensitive and thus presumably a thioester bond. However, contrary to expectations, palmitate incorporation was blocked completely by the protein synthesis inhibitors cycloheximide and puromycin. In parallel experiments to show specificity, palmitoylation of aortic endothelial cell-specific nitric-oxide synthase was unaffected by these reagents. Inhibitors of protein trafficking, brefeldin A and monensin, blocked caveolin-1 palmitoylation, indicating that the modification was not cotranslational but rather required caveolin-1 transport from the endoplasmic reticulum and Golgi to the plasma membrane. In addition, immunophilin chaperones that form complexes with caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary for caveolin-1 palmitoylation because agents that bind immunophilins did not inhibit palmitoylation. Pulse-chase experiments showed that caveolin-1 palmitoylation is essentially irreversible because the release of [(3)H]palmitate was not significant even after 24 h. These results show that [(3)H]palmitate incorporation is limited to newly synthesized caveolin-1, not because incorporation only occurs during synthesis but because the continuous presence of palmitate on caveolin-1 prevents subsequent repalmitoylation. (+info)Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein. (4/314)
While several cellular proteins are incorporated in the human immunodeficiency virus type 1 virion, cyclophilin (CyP) A is the only one whose absence has been demonstrated to impair infectivity. Incorporation of the cytosolic protein results from interaction with a highly exposed Pro-rich loop in the N-terminal region of the capsid (CA) domain of the precursor polyprotein, Pr55(Gag). Even when prevented from interacting with CyP A, Pr55Gag still forms particles that proceed to mature into morphologically wild-type virions, suggesting that CyP A influences a postassembly event. The nature of this CyP A influence has yet to be elucidated. Here, we show that while CyP A binds both Gag and mature CA proteins, the two binding interactions are actually different. Tryptophan 121 (W121) in CyP A distinguished the two proteins: a phenylalanine substitution (W121F) impaired binding of mature CA protein but not of Gag. This indicates the occurrence of a maturation-dependent switch in the conformation of the Pro-rich loop. A structural consequence of Gag binding to CyP A was to block this maturational refolding, resulting in a 24-kDa CA protein retaining the immature Pro-rich loop conformation. Using trypsin as a structure probe, we demonstrate that the conformation of the C-terminal region in mature CA is also a product of maturational refolding. Binding to wild-type CyP A altered this conformation, as indicated by a reduction in the accessibility of Cys residue(s) in the region to chemical modification. Hence, the end result of binding to CyP A, whether the Pro-rich loop is in the context of Gag or mature CA protein, is a structurally modified mature CA protein. The postassembly role of CyP A may be mediated through these modified mature CA proteins. (+info)Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle. (5/314)
Sanglifehrin A (SFA) is a novel immunosuppressive natural product that binds to cyclophilin but is structurally distinct from cyclosporin A (CsA). We have investigated the cellular and molecular mechanisms of the action of SFA in T lymphocytes. We show that SFA inhibits T cell proliferation induced by IL-2 with an IC(50) of 200 nM. Distinct from CsA, which also binds to cyclophilin, SFA does not affect calcium-dependent IL-2 production, although SFA enhanced IL-2 gene transcription in the same cells. SFA blocks T cell proliferation induced by IL-2 in G(1) with no appreciable effect on IL-2 receptor expression in a manner similar to that of the immunosuppressant rapamycin. Unlike rapamycin, however, SFA has no effect on the phosphorylation or enzymatic activity of p70(s6k) kinase, distinguishing SFA from rapamycin in their mode of action. SFA inhibits hyperphosphorylation of Rb and the activity of cyclin E-cyclin-dependent kinase 2 on IL-2 signaling. These results suggest that SFA has a novel mode of action in comparison with CsA, FK506, and rapamycin, and that its use as a molecular probe may lead to the discovery of a novel target involved in T cell activation. (+info)CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. (6/314)
Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies implicated CD147 as a receptor for extracellular CyPA. Here, we demonstrate a role for CyPA-CD147 interaction during the early steps of HIV-1 infection. Expression of human CD147 increased infection by HIV-1 under one-cycle conditions. However, susceptibility to infection by viruses lacking CyPA (simian immunodeficiency virus or HIV-1 produced in the presence of cyclosporin A) was unaffected by CD147. Virus-associated CyPA coimmunoprecipitated with CD147 from infected cells. Antibody to CD147 inhibited HIV-1 entry as evidenced by the delay in translocation of the HIV-1 core proteins from the membrane and inhibition of viral reverse transcription. Viruses whose replication did not require CyPA (SIV or mutant HIV-1) were resistant to the inhibitory effect of anti-CD147 antibody. These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell. (+info)A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding. (7/314)
The folding of apo-pseudoazurin, a 123-residue, predominantly beta-sheet protein with a complex Greek key topology, has been investigated using several biophysical techniques. Kinetic analysis of refolding using far- and near-ultraviolet circular dichroism (UV CD) shows that the protein folds slowly to the native state with rate constants of 0.04 and 0.03 min(-1), respectively, at pH 7.0 and at 15 degrees C. This process has an activation enthalpy of approximately 90 kJ/mole and is catalyzed by cyclophilin A, indicating that folding is limited by trans-cis proline isomerization, presumably around the Xaa-Pro 20 bond that is in the cis isomer in the native state. Before proline isomerization, an intermediate accumulates during folding. This species has a substantial signal in the far-UV CD, a nonnative signal in the near-UV CD, exposed hydrophobic surfaces (judged by 1-anilino naphthalenesulphonate binding), a noncooperative denaturation transition, and a dynamic structure (revealed by line broadening on the nuclear magnetic resonance time scale). We compare the properties of this intermediate with partially folded states of other proteins and discuss its role in folding of this complex Greek key protein. (+info)Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. (8/314)
Six distinct peroxiredoxin (Prx) proteins (Prx I-VI) from distinct genes have been identified in mammalian tissues. Prxs are members of a group of peroxidases that have conserved reactive cysteine residue(s) in the active site(s). An immediate physiological electron donor for the peroxidase catalysis for five Prx proteins (Prx I-V) has been identified as thioredoxin (Trx), but that for Prx VI (1-Cys Prx) is still unclear. To identify an immediate electron donor and a binding protein for Prx VI, we performed a Prx VI protein overlay assay. A 20-kDa binding protein was identified by the Prx VI protein overlay assay with flow-through fractions from a High-Q column with rat lung crude extracts. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and MS-Fit, we identified the 20-kDa Prx VI-binding protein as a cyclophilin A (CyP-A). The binding of recombinant human CyP-A (hCyP-A) to Prx VI was confirmed by using the hCyP-A protein overlay assay and Western immunoblot analysis with hCyP-A-specific antibodies. hCyP-A enhanced the antioxidant activity of Prx VI, as well as the other known mammalian Prx isotypes. hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems. Prx II was reduced by hCyP-A without help from any other reductant, and the reduction was cyclosporin A-independent. These results strongly suggest that CyP-A not only binds to Prx proteins but also supports its peroxidase activity as an immediate electron donor. In addition, Cys(115) and Cys(161) of hCyP-A were found to be involved in the activation and the reduction of Prx. (+info)
Interaction of cyclophilin A with a novel binding protein, SR-25, and characterization of their expression pattern in Chinese...
Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity
Title page for ETD etd-12042017-090452
Cyclophilin H / PPIH (1-177) - AR09072PU-L | acris-antibodies.com
Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice |...
Recombinant human Cyclophilin 40 protein (ab78815) References
Recombinant Human Cyclophilin E protein (His tag) (ab206449) | Abcam
Highlights of our Work
25th week of 2011 patent applcation highlights part 64
Study Sheds Light on Aneurysm Prevention
- HealthManagement.org
Regulation of HIV-1 Host Factor Interactions by Cyclophilin A - Mallori Burse
Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site - The Division of Structural Biology
RCSB PDB - 6GJM: Cyclophilin A complexed with tri-vector ligand 4.
Anti Human TRIM5 Alpha (N-Terminal) Antibody | Bio-Rad
Anti-Cyclophilin 40 抗体 (ab3562) | アブカム
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TRIM50抗体| Abcam中国
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Cyclophilin | definition of cyclophilin by Medical dictionary
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?<...
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Involvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning
Lirias: DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans...
Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with...
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Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the...
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Structure Cluster
- 3RCL: Human Cyclophilin D Complexed with a Fragment 3D Similarity Report Page
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PLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
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Post-translational modifications
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Accell siRNA
Download Soil Mechanics
Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the...
Elegant Trim Return Address by 123Print
Cyclophilin
Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a calcium/ ... Cyclophilin A is a cytosolic and highly abundant protein. The protein belongs to a family of isozymes, including cyclophilins B ... Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is ... Cyclophilin inhibitors, such as cyclosporin, are being developed to treat neurodegenerative diseases. Cyclophilin inhibition ...
PRPF3
Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a ... Horowitz DS, Lee EJ, Mabon SA, Misteli T (Feb 2002). "A cyclophilin functions in pre-mRNA splicing". The EMBO Journal. 21 (3): ... a nuclear cyclophilin" (PDF). The Journal of Biological Chemistry. 275 (11): 7439-42. doi:10.1074/jbc.275.11.7439. PMID ... "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". Journal of Molecular ...
RANBP2
Ferreira PA, Nakayama TA, Pak WL, Travis GH (Oct 1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green ... Ferreira PA, Yunfei C, Schick D, Roepman R (Sep 1998). "The cyclophilin-like domain mediates the association of Ran-binding ... Yi H, Friedman JL, Ferreira PA (Nov 2007). "The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the ... Ferreira PA, Hom JT, Pak WL (Sep 1995). "Retina-specifically expressed novel subtypes of bovine cyclophilin". The Journal of ...
PPIL2
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ... 2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866-71. doi: ... "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2". Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). " ... 2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. ...
PPIL3
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide ... Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the ... "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high ... cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3-4): 231-6. doi:10.1159/000056909 ...
PPIL1
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved ... "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical ... expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. ...
Cis-trans isomerase
Examples include photoisomerase and immunophilins such as cyclophilin. cis-trans-Isomerases at the US National Library of ...
PPIF
As a cyclophilin, PPIF binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Like other cyclophilins, PPIF forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a ...
PPIL4
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, ... "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4". Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, ... structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell ...
Alisporivir
It inhibits cyclophilin A. Alisporivir is not immunosuppressive. It is being researched for potential use in the treatment of ... Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of, and ... April 2008). "Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin ... December 2008). "Debio 025, a cyclophilin binding molecule, is highly efficient in clearing HCV replicon containing cells, ...
Peptidylprolyl isomerase A
Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ... Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by ... Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in ...
PPIB
As a cyclophilin, PPIB binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene ... Mikol V, Kallen J, Walkinshaw MD (1994). "X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A ... As a cyclophilin, PPIB binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. PPIB is the ...
PPIC
As a cyclophilin, PPIC binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Depletion of these two cyclophilins lead to hyperoxidation of the ER. In the brain, PPIC complexes with cyclophilin C- ... Like other cyclophilins, PPIC forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ...
Peptidylprolyl isomerase D
As a cyclophilin, PPID binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on ... Like other cyclophilins, PPID forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ...
PPIE (gene)
As a cyclophilin, PPIE also binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on ... Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, Sun L, Gao GF, Ye X, Liu W (2011). "Cyclophilin E functions as a negative ...
CLK1
Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin ...
FKBP
... which binds cyclophilin. Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called ... Along with cyclophilin, FKBPs belong to the immunophilin family. FKBP12 is notable in humans for binding the immunosuppressant ... FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins ... Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ...
PPIG (gene)
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR ... Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (Jan 1997). "RS cyclophilins: identification of an NK-TR1-related ... "Entrez Gene: PPIG peptidylprolyl isomerase G (cyclophilin G)". Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (Aug 2004). " ... 2004). "The human nuclear SRcyp is a cell cycle-regulated cyclophilin". J. Biol. Chem. 279 (21): 22322-30. doi:10.1074/jbc. ...
Calcium modulating ligand
When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein ... Bram RJ, Crabtree GR (1994). "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein". Nature. 371 (6495 ... Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ (2000). "Calcium-modulating cyclophilin ligand desensitizes hormone-evoked ... Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of ...
Methods used to study memory
The Role of Cyclophilin D in learning and memory. Brush, F. Robert (2003). "Selection for Differences in avoidance Learning: ...
Ischemia-reperfusion injury of the appendicular musculoskeletal system
To the end of this, necrosis occurs by physical interaction with the PTP regulator cyclophilin D (CypD). The mitochondrial p53- ... Alam, M.R.; D. Baetz; M. Ovize (2015). "Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective". J Mol ...
Ciclosporin
Cyclosporin A binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, ... It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases ... This cyclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of ... Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding ...
Hypothermia therapy for neonatal encephalopathy
February 2009). "Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury". The Journal of ...
Bump and hole
... cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair was ... The bumped cyclosporin A was found to interact efficiently with the hole-modified cyclophilin mutant, but not endogenous ... cyclophilin. The orthogonal CID pair was used to inhibit calcineurin-mediated dephosphorylation of nuclear factor of activated ... engineered to improve the binding efficiency between wild type cyclosporin A and cyclophilin, thereby giving more efficient CID ...
OPN1MW
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
List of examples of convergent evolution
Examples comprise fibronectin/long chain cytokines, NEF/SH2, cyclophilin/capsid proteins. The most well-studied example is the ...
Hereditary equine regional dermal asthenia
2009). "Methods for detecting a cyclophilin B SNP associated with HERDA". Retrieved September 2, 2016. Horsetalk.co.nz: HERDA a ... "Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the ...
OPN1LW
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
Basigin
... is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... Yurchenko V, Constant S, Bukrinsky M (March 2006). "Dealing with the family: CD147 interactions with cyclophilins". Immunology ...
FKBP1A
Yang WM, Inouye CJ, Seto E (Jun 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The ... a peptidylprolyl cis-trans isomerase distinct from cyclophilin". Proceedings of the National Academy of Sciences of the United ...
JCI -
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and ... Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular ...
Functional association of cyclophilin A with HIV-1 virions | Semantic Scholar
CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase ... Drug-induced reductions in virion-associated cyclophilin A levels were accompanied by reductions in virion infectivity, ... The association of cyclophilin A with HIV-1 virions was inhibited in a dose-dependent manner by cyclosporin A as well as by SDZ ... contain significant amounts of cyclophilin A. Sequences in the capsid domain of p55gag are both required and sufficient for the ...
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCO
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. By Shivam Yadav, Martin ... Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. Most of them ... Here, we show that cyclophilin anaCyp40 from the cyanobacterium Anabaena sp. PCC 7120 is enzymatically active, and seems to be ... The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and ...
RCSB PDB - 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.
Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. ... Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.. *PDB DOI: ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ...
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70<...
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. A. Carrello, Rudi Allan, Sarah Morgan, B.A.L. Owen, D. Mok, B.K ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. / Carrello, A.; Allan, Rudi; Morgan, Sarah et al. ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. In: Cell Stress & Chaperones. 2004 ; Vol. 9. pp. 167-181. ... Dive into the research topics of Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Together they form a unique ...
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic...
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ... We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB ... Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ...
Cyclophilin D deficiency prevents diet-induced obesity in mice - Fingerprint - Research Nebraska
Rat CYPA (Cyclophilin A) ELISA Kit - BidScientific.com
S-EPMC145517 - Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. - OmicsDI
Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 ... cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gags interaction with cyclophilins ... indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific ... Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. ...
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach<...
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. / Ni, Shuaishuai; Yuan, Yaxia ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. In: Journal of Medicinal ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. Journal of Medicinal ... Dive into the research topics of Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design ...
Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial...
... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D, Neuroscience, vol. 155, no. 3, pp. 585-596 ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. In: Neuroscience. 2008 ; Vol. 155, No. 3. pp ... encoding mitochondrial cyclophilin D (CyPD). Mitochondrial CyPD is a key modulator of the mitochondrial permeability transition ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. Neuroscience. 2008 Aug 26;155(3):585-596. ...
Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with antifungal...
Of which, 65 GhCYPs only contained one cyclophilin type PPIase domain, others 14 GhCYPs contain additional domains. A number of ... Cyclophilins (CYPs), belonging to the peptidyl prolyl cis/trans isomerase (PPIase) superfamily, play important roles during ... From: Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with ...
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...
Twelve of the 17 human cyclophilins and both human parvulins, but only one of the 13 human FKBPs, identified orthologues within ... whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more ... multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle ... whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. A comparison of their known functions ...
Cerebrovascular Insulin Receptors Are Defective in AD
IMSEAR at SEARO: A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli.
By using this method, highly purified GST-cyclophilin A (CypA) fusion protein was obtained, without affecting the structural ... A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. ... A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. Indian Journal of Biochemistry ...
Letters To The Editor
Cloning and Expression Analysis of Cyclophilins A(<em>CyPA</em>) Gene...
Cyclophilins (CyPs) are widely distributed in organisms, and play impo... ... Abstract: Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. Cyclophilin A-like was screened in ... Cloning and Expression Analysis of Cyclophilins A(CyPA) Gene form Chlorella WANG Xu-Hui;QIAO Kun;WANG Zhen-Juan;GUAN Qing-Jie*; ... So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in ...
Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through...
2igv.1 | SWISS-MODEL Template Library
Hypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews Nephrology
Crosstalk between cyclophilins and T lymphocytes in coronary artery disease | Documentos - Universidade de Santiago de...
PPIAP74 peptidylprolyl isomerase A pseudogene 74 [Homo sapiens (human)] - Gene - NCBI
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to...
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ...
Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas...
Fischkoff SA[au] - Search Results - PubMed
DeCS - Termos Novos
Potential adverse effects of nanoparticles on the reproductive system | IJN
TCDB » SEARCH
Plus it
... cyclophilin forward, 5′-AGG TCC TGG CAT CTT GTC CAT-3′, cyclophilin reverse, 5′-GAA CCG TTT GTG TTT GGT CCA-3′ (amplicon length ... C, Detection of RAGE and cyclophilin mRNA in blood by real-time RT-PCR confirmed the efficiency of bone-marrow transplantation ... 51 bp). Quantified results of RAGE cDNA were normalized to cyclophilin. The purity of the amplified products was checked by the ...
CyPA8
- Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. (omicsdi.org)
- Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis-trans isomerases (PPIases), which can bind to cyclosporin A (CsA). (omicsdi.org)
- This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3). (uthscsa.edu)
- By using this method, highly purified GST-cyclophilin A (CypA) fusion protein was obtained, without affecting the structural and functional characteristics such as PPIase and chaperone activities. (who.int)
- Studies showed cyclophilin A (CypA) playing an important role in regulating MMP -9 expression in varied diseases . (bvsalud.org)
- So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in improving survival ability of resistant organisms. (nefu.edu.cn)
- Cloning and Expression Analysis of Cyclophilins A( CyPA ) Gene form Chlorella[J]. Bulletin of Botanical Research, 2014, 34(2): 245-251. (nefu.edu.cn)
- Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. (cnr.it)
Mitochondrial6
- In neonatal mice and cultured differentiating oligodendrocytes, sublethal intermittent hypoxic (IH) stress activated cyclophilin D-dependent mitochondrial proton leak and uncoupled mitochondrial respiration, leading to transient bioenergetic stress. (jci.org)
- Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular mechanism for the maturational failure of oligodendrocytes and offers a potential therapeutic target for prevention of diffuse WMI in premature infants experiencing chronic IH stress. (jci.org)
- In this report, we have assessed the behavioral responses of mice missing the Ppif gene (CyPD-KO), encoding mitochondrial cyclophilin D (CyPD). (elsevier.com)
- Dive into the research topics of 'Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D'. Together they form a unique fingerprint. (elsevier.com)
- The non-immunosuppressive cyclophilin inhibitor NIM811 prevented mitochondrial depolarization in response to oligomycin in melanocytes from both Ullrich congenital muscular dystrophy and Bethlem myopathy patients, and partially restored the respiratory reserve of melanocytes from one Bethlem myopathy patient. (elsevier.com)
- Several NSAIDs indeed trigger increases in mobile [Ca2+] and oxidant tension (Tanaka research with cultured enterocytes, where high concentrations of diclofenac could actually trigger cyclosporin ACsensitive adjustments in calcein/Co2+ fluorescence, a recognized indicator from the mPT (LoGuidice by focusing on cyclophilin D (CypD), a mitochondrial matrix proteins and important regulator from the mPT. (cancerhugs.com)
Protein7
- Cyclophilin A acts as protein folding chaperones and intracellular transports in many cellular processes. (omicsdi.org)
- Previous studies have shown that cyclophilin A can interact with HIV-1 (human immunodeficiency virus type 1) gag protein and enhance viral infectivity. (omicsdi.org)
- A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)
- The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
- IMSEAR at SEARO: A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. (who.int)
- Cyclophilin B is an accessory activating protein ( Stumpf et al . (tcdb.org)
- Each sample was analyzed for the expression of two candidate genes, aromatase (CYP19) and peroxisome proliferator activated receptor protein gamma (PPARgamma) and three potential internal controls: cyclophilin (CYC), 18S rRNA (18S), and total RNA. (cdc.gov)
Activity of cyclophilin2
- Following a computer-aided virtual screening and subsequent surface plasmon resonance (SPR) analysis, 12 low molecular weight cyclophilin A ligands were selected for further evaluation of their in vitro inhibition of peptidyl-prolyl cis-trans isomerase (PPIase) activity of cyclophilin A and HIV-1 replication. (omicsdi.org)
- Leukocyte chemotactic activity of cyclophilin. (nih.gov)
Inhibitors4
- Many cyclophilin A inhibitors such as cyclosporin A can inhibit HIV-1 replication in vitro. (omicsdi.org)
- Here, we report a structure-based identification of novel non-peptidic cyclophilin A inhibitors as anti-HIV lead compounds. (omicsdi.org)
- Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. (omicsdi.org)
- Certain drugs of the cyclosporine family, such as cyclosporin A (CsA), are reversible inhibitors of mPT via direct interaction with cyclophilin D, which is a known part of the pore forming complex. (lu.se)
Immunophilins2
- Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. (jascoinc.com)
- Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. (usc.es)
PPIase2
- 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. (rcsb.org)
- Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. (biomedcentral.com)
Cyclosporin4
- CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase activity, and assist in the folding of proteins1 6. (semanticscholar.org)
- Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. (semanticscholar.org)
- HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. (omicsdi.org)
- In a successive evaluation of 12 putative mPT inhibiting compounds, none displayed effects comparable to cyclophilin D inhibition by the non-immunosuppressive cyclophilin inhibitor D-MeAla3-EtVal4-Cyclosporin (Debio 025). (lu.se)
Gene3
- Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (omicsdi.org)
- Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (cdc.gov)
- Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression. (cdc.gov)
Small molecule1
- Structure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity. (omicsdi.org)
CyPs1
- Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. (nefu.edu.cn)
CypB1
- We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB). (duke.edu)
Recombinant1
- Aβ_(25-35) (Sigma, USA), antibodies of Bcl-2 and Bax (Wuhan Boster, China), and recombinant human cyclophilin A (Biomol, USA) were used in this study. (imr.ac.cn)
Interacts1
- Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (rochester.edu)
Prolyl1
- The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. (omicsdi.org)
Arabidopsis2
- The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and presents features that are absent in single-domain cyclophilins. (jascoinc.com)
- Prokaryotic Expression,Activity Assay of Chlorella Cyclophilin A and Salt Tolerance Analysis of Arabidopsis Over-expressing CsCyp1A [J]. Bulletin of Botanical Research, 2017, 37(5): 722-729. (nefu.edu.cn)
Mice2
- Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and fully preserved oligodendrocyte maturation, axonal myelination, and neurofunction. (jci.org)
- Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone. (rochester.edu)
Replication2
- These active compounds will be used as leads for structure and activity relationship (SAR) and optimization studies in order to design more effective anti-HIV-1 therapeutics, and as probes for investigating the effect of cyclophilins on HIV-1 replication. (omicsdi.org)
- Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. (lumc.nl)
Functional1
- These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophin A to initiate infection. (semanticscholar.org)
Survival1
- Cyclophilin A enhanced the survival rate of PC12 cells to Aβ_(25-35)-induced apoptosis (t = 4.895, 10.042, P (imr.ac.cn)
Cells4
- Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through cyclophilin A. (bvsalud.org)
- Cells in the cyclophilin A group were incubated in medium containing a final con-centration of 10 nmol/L of cyclophilin A for 30 minutes, and then treated with 10 μmol/L Aβ_(25-35).MAIN OUTCOME MEASURES: After 24 hours of culture, immunohistochemistry was used to detect Bcl-2 and Bax expression in PC12 cells. (imr.ac.cn)
- However, in PC12 cells treated with Aβ_(25-35) and cyclophilin A, Bcl-2 expression increased and Bax expression decreased (t = 4.497, 2.531, P (imr.ac.cn)
- CONCLUSION: Cyclophilin A can increase Bcl-2 expression and decrease Bax expression in PC12 cells treated with Aβ_(25-35), which indicates that cyclophilin A has a protective effect on Aβ_(25-35)-induced injury to PC12 cells. (imr.ac.cn)
Domain2
- Elucidation of the anaCyp40 crystal structure at 1.2-Å resolution reveals an N-terminal helical domain with similarity to PsbQ components of plant photosystem II, and a C-terminal cyclophilin domain with a substrate-binding site. (jascoinc.com)
- Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. (biomedcentral.com)
Cell2
- Human cyclophilins A and B are host cell proteins that bind specifically to the HIV-1 Gag polyprotein p55gag in vitro7. (semanticscholar.org)
- Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. (duke.edu)
Role2
- Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. (semanticscholar.org)
- Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation. (rochester.edu)
Study1
- Cyclophilin A-like was screened in our study from Chlorella sp. (nefu.edu.cn)