A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Transport proteins that carry specific substances in the blood or across cell membranes.
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides. (From Enzyme Nomenclature, 1992) EC 3.4.21.62.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.
A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
Established cell cultures that have the potential to propagate indefinitely.
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Proteins which bind calmodulin. They are found in many tissues and have a variety of functions including F-actin cross-linking properties, inhibition of cyclic nucleotide phosphodiesterase and calcium and magnesium ATPases.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A subtype of thioredoxins found primarily in CHLOROPLASTS.
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
A family of RNA plant viruses infecting disparate plant families. They are transmitted by specific aphid vectors. There are three genera: LUTEOVIRUS; Polerovirus; and Enamovirus.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.
Proteins prepared by recombinant DNA technology.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).

Cyclophilin A is a secreted growth factor induced by oxidative stress. (1/314)

Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis, hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. Many VSMC growth factors are secreted by VSMC and act in an autocrine manner. Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Human recombinant CyPA can mimic the effects of secreted CyPA to stimulate ERK1/2 and cell growth. The peptidyl-prolyl isomerase activity is required for ERK1/2 activation by CyPA. In vivo, CyPA expression and secretion are increased by oxidative stress and vascular injury. These findings are the first to identify CyPA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases.  (+info)

Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (2/314)

The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. To determine whether CypA promotes HIV-1 replication, we deleted the gene encoding CypA (PPIA) in human CD4(+) T cells by homologous recombination. HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific for wild-type HIV-1 since HIV-2/SIV isolates, as well as HIV-1 bearing a gag mutation that confers cyclosporin resistance, replicated the same in PPIA(+/+) and PPIA(-/-) cells. Stable re-expression of CypA in PPIA(-/-) cells restored HIV-1 replication to an extent that correlated with steady-state levels of CypA. Finally, virions from PPIA(-/-) cells possessed no obvious biochemical abnormalities but were less infectious than virions from wild-type cells. These data formally demonstrate that CypA regulates the infectivity of HIV-1 virions.  (+info)

Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. (3/314)

Caveolin-1 is a palmitoylated protein involved in assembly of signaling molecules in plasma membrane subdomains termed caveolae and in intracellular cholesterol transport. Three cysteine residues in the C terminus of caveolin-1 are subject to palmitoylation, which is not necessary for caveolar targeting of caveolin-1. Protein palmitoylation is a post-translational and reversible modification that may be regulated and that in turn may regulate conformation, membrane association, protein-protein interactions, and intracellular localization of the target protein. We have undertaken a detailed analysis of [(3)H]palmitate incorporation into caveolin-1 in aortic endothelial cells. The linkage of palmitate to caveolin-1 was hydroxylamine-sensitive and thus presumably a thioester bond. However, contrary to expectations, palmitate incorporation was blocked completely by the protein synthesis inhibitors cycloheximide and puromycin. In parallel experiments to show specificity, palmitoylation of aortic endothelial cell-specific nitric-oxide synthase was unaffected by these reagents. Inhibitors of protein trafficking, brefeldin A and monensin, blocked caveolin-1 palmitoylation, indicating that the modification was not cotranslational but rather required caveolin-1 transport from the endoplasmic reticulum and Golgi to the plasma membrane. In addition, immunophilin chaperones that form complexes with caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary for caveolin-1 palmitoylation because agents that bind immunophilins did not inhibit palmitoylation. Pulse-chase experiments showed that caveolin-1 palmitoylation is essentially irreversible because the release of [(3)H]palmitate was not significant even after 24 h. These results show that [(3)H]palmitate incorporation is limited to newly synthesized caveolin-1, not because incorporation only occurs during synthesis but because the continuous presence of palmitate on caveolin-1 prevents subsequent repalmitoylation.  (+info)

Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein. (4/314)

While several cellular proteins are incorporated in the human immunodeficiency virus type 1 virion, cyclophilin (CyP) A is the only one whose absence has been demonstrated to impair infectivity. Incorporation of the cytosolic protein results from interaction with a highly exposed Pro-rich loop in the N-terminal region of the capsid (CA) domain of the precursor polyprotein, Pr55(Gag). Even when prevented from interacting with CyP A, Pr55Gag still forms particles that proceed to mature into morphologically wild-type virions, suggesting that CyP A influences a postassembly event. The nature of this CyP A influence has yet to be elucidated. Here, we show that while CyP A binds both Gag and mature CA proteins, the two binding interactions are actually different. Tryptophan 121 (W121) in CyP A distinguished the two proteins: a phenylalanine substitution (W121F) impaired binding of mature CA protein but not of Gag. This indicates the occurrence of a maturation-dependent switch in the conformation of the Pro-rich loop. A structural consequence of Gag binding to CyP A was to block this maturational refolding, resulting in a 24-kDa CA protein retaining the immature Pro-rich loop conformation. Using trypsin as a structure probe, we demonstrate that the conformation of the C-terminal region in mature CA is also a product of maturational refolding. Binding to wild-type CyP A altered this conformation, as indicated by a reduction in the accessibility of Cys residue(s) in the region to chemical modification. Hence, the end result of binding to CyP A, whether the Pro-rich loop is in the context of Gag or mature CA protein, is a structurally modified mature CA protein. The postassembly role of CyP A may be mediated through these modified mature CA proteins.  (+info)

Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle. (5/314)

Sanglifehrin A (SFA) is a novel immunosuppressive natural product that binds to cyclophilin but is structurally distinct from cyclosporin A (CsA). We have investigated the cellular and molecular mechanisms of the action of SFA in T lymphocytes. We show that SFA inhibits T cell proliferation induced by IL-2 with an IC(50) of 200 nM. Distinct from CsA, which also binds to cyclophilin, SFA does not affect calcium-dependent IL-2 production, although SFA enhanced IL-2 gene transcription in the same cells. SFA blocks T cell proliferation induced by IL-2 in G(1) with no appreciable effect on IL-2 receptor expression in a manner similar to that of the immunosuppressant rapamycin. Unlike rapamycin, however, SFA has no effect on the phosphorylation or enzymatic activity of p70(s6k) kinase, distinguishing SFA from rapamycin in their mode of action. SFA inhibits hyperphosphorylation of Rb and the activity of cyclin E-cyclin-dependent kinase 2 on IL-2 signaling. These results suggest that SFA has a novel mode of action in comparison with CsA, FK506, and rapamycin, and that its use as a molecular probe may lead to the discovery of a novel target involved in T cell activation.  (+info)

CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. (6/314)

Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies implicated CD147 as a receptor for extracellular CyPA. Here, we demonstrate a role for CyPA-CD147 interaction during the early steps of HIV-1 infection. Expression of human CD147 increased infection by HIV-1 under one-cycle conditions. However, susceptibility to infection by viruses lacking CyPA (simian immunodeficiency virus or HIV-1 produced in the presence of cyclosporin A) was unaffected by CD147. Virus-associated CyPA coimmunoprecipitated with CD147 from infected cells. Antibody to CD147 inhibited HIV-1 entry as evidenced by the delay in translocation of the HIV-1 core proteins from the membrane and inhibition of viral reverse transcription. Viruses whose replication did not require CyPA (SIV or mutant HIV-1) were resistant to the inhibitory effect of anti-CD147 antibody. These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell.  (+info)

A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding. (7/314)

The folding of apo-pseudoazurin, a 123-residue, predominantly beta-sheet protein with a complex Greek key topology, has been investigated using several biophysical techniques. Kinetic analysis of refolding using far- and near-ultraviolet circular dichroism (UV CD) shows that the protein folds slowly to the native state with rate constants of 0.04 and 0.03 min(-1), respectively, at pH 7.0 and at 15 degrees C. This process has an activation enthalpy of approximately 90 kJ/mole and is catalyzed by cyclophilin A, indicating that folding is limited by trans-cis proline isomerization, presumably around the Xaa-Pro 20 bond that is in the cis isomer in the native state. Before proline isomerization, an intermediate accumulates during folding. This species has a substantial signal in the far-UV CD, a nonnative signal in the near-UV CD, exposed hydrophobic surfaces (judged by 1-anilino naphthalenesulphonate binding), a noncooperative denaturation transition, and a dynamic structure (revealed by line broadening on the nuclear magnetic resonance time scale). We compare the properties of this intermediate with partially folded states of other proteins and discuss its role in folding of this complex Greek key protein.  (+info)

Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. (8/314)

Six distinct peroxiredoxin (Prx) proteins (Prx I-VI) from distinct genes have been identified in mammalian tissues. Prxs are members of a group of peroxidases that have conserved reactive cysteine residue(s) in the active site(s). An immediate physiological electron donor for the peroxidase catalysis for five Prx proteins (Prx I-V) has been identified as thioredoxin (Trx), but that for Prx VI (1-Cys Prx) is still unclear. To identify an immediate electron donor and a binding protein for Prx VI, we performed a Prx VI protein overlay assay. A 20-kDa binding protein was identified by the Prx VI protein overlay assay with flow-through fractions from a High-Q column with rat lung crude extracts. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and MS-Fit, we identified the 20-kDa Prx VI-binding protein as a cyclophilin A (CyP-A). The binding of recombinant human CyP-A (hCyP-A) to Prx VI was confirmed by using the hCyP-A protein overlay assay and Western immunoblot analysis with hCyP-A-specific antibodies. hCyP-A enhanced the antioxidant activity of Prx VI, as well as the other known mammalian Prx isotypes. hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems. Prx II was reduced by hCyP-A without help from any other reductant, and the reduction was cyclosporin A-independent. These results strongly suggest that CyP-A not only binds to Prx proteins but also supports its peroxidase activity as an immediate electron donor. In addition, Cys(115) and Cys(161) of hCyP-A were found to be involved in the activation and the reduction of Prx.  (+info)

Cyclophilin (Cyp) A has been reported to be overexpressed in the majority of cancer cells, including hepatocellular carcinoma (HCC). However, the biological functions of CypA in HCC are far from being understood. To determine the biological functions of CypA in HCC, the present study screened human fetal liver complementary DNA for proteins interacting with CypA using the yeast two-hybrid system. A nuclear protein, serine/arginine-rich (SR)-25, was isolated as a novel CypA-binding protein that is distinct from those previously described in the literature. Binding assays and co-immunoprecipitation confirmed the physical association between CypA and SR-25. The present study demonstrated that CypA may interact with SR-25 through its peptidyl-prolyl isomerase domain. In addition, CypA may induce the expression of SR-25 in Hep3B cells. The messenger RNA levels of CypA and SR-25 in HCC indicated that there was a significant correlation between the expression of CypA and the expression of SR-25 in HCC. It can
Optimal HIV-1 infectivity requires the presence of both the viral factor Nef and the cellular protein cyclophilin A (CyPA) during virion assembly. These two proteins are integral components of HIV-1 particles. Both CyPA and Nef facilitate a step in the viral life cycle occurring between penetration …
The host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral capsid (CA). CypA enhances the early stages of HIV-1 infection in part by promoting nuclear import of the virus; while the details of its ability to inhibit HIV-1 infection are less clear. This thesis advances our understanding of the mechanisms underlying the ability of CypA to inhibit HIV-1 infection. I demonstrate that CypA inhibits nuclear import of HIV-1 in the presence of inhibitory capsid-binding host proteins TRIM5α and CPSF6, and that inhibition is not a consequence of increased binding of inhibitory factors to the viral capsid. My work also demonstrates that CypA-dependent inhibition depends in part, on a conserved domain of HIV-1 CA which determines interactions with host nuclear pore proteins. These results suggest a common mechanism underlies the ability of CypA to stimulate HIV-1 infectivity in some cells and to inhibit infection in others. ...
Cyclophilin H / PPIH, 0.5 mg. Cyclophilin H (also known as peptidylpropyl isomerase H, PPIH) is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Background: Cyclophilin A (CyPA, encoded by Ppia) is a ubiquitously expressed protein secreted in response to pro-inflammatory stimuli. CyPA stimulates VSMC migration and proliferation, endothelial cell adhesion molecule expression and inflammatory cell chemotaxis. Given these activities, we hypothesized that CyPA is pro-atherogenic.. Methods and Results: In the high cholesterol diet fed Apoe-/- mouse CyPA deficiency led to a reduction of atherosclerosis (% Oil Red O, en face aorta; 19.3±7.5 in Apoe-/- vs. 8.2±2.0 in Apoe-/-Ppia-/- mice, P,0.01). CyPA deficiency was associated with decreased LDL uptake, inflammatory cell accumulation, and apoptosis. Moreover, en face staining of aortic tissues showed that VCAM-1 expression was significantly reduced in mice lacking CyPA. Importantly, eNOS protein expression was significantly higher in the Apoe-/-Ppia-/- mice compared to Apoe-/- mice. To define the mechanisms responsible for decreased eNOS expression, the effect of altering CyPA levels in ...
References for Abcams Recombinant human Cyclophilin 40 protein (ab78815). Please let us know if you have used this product in your publication
Recombinant Human Cyclophilin E protein (His tag) is an Escherichia coli Full length protein 2 to 301 aa range, | 95% purity, | 1.000 Eu/µg endotoxin level and validated in SDS-PAGE, MS.
When human immundeficiency virus (HIV) infects a human cell, it releases into the interior of the cell its capsid (made of about 1,300 identical so-called CA proteins), a closed, stable container that protects the viral genetic material (see also June 2013 highlight Elusive HIV-1 Capsid and August 2015 highlight Anatomy of a Dormant Killer). Once in the cell ― while avoiding detection by cellular proteins ― the capsid deceives the cell and directs the cell machinery to transport it to the nucleus. The human-cell protein Cyclophilin A (CypA) is thereby exploited to act against the cells well being and to assist the HIV infection by getting the capsid to access the cell nucleus; this results in a delicate choreography accomplished by escaping anti-viral proteins in the cell and deceiving transport proteins at the nucleus, all of which contain a CypA domain that interacts directly with the capsid. Despite the availability of the crystal structure of the complex of CypA and CA proteins ...
NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such ...
Researchers at the University of Rochester Medical Center in New York said removing the gene that makes the protein cyclophilin A protected mice genetica
The HIV-1 capsid is an important determinant of viral replication. Early studies demonstrated the intrinsic importance of the capsid in mediating uncoating of t...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
ウサギ・ポリクローナル抗体 ab3562 交差種: Ms,Rat,Rb,Chk,Cow,Hu,NHuPrm 適用: WB,IP,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…Cyclophilin…
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Looking for online definition of cyclophilin in the Medical Dictionary? cyclophilin explanation free. What is cyclophilin? Meaning of cyclophilin medical term. What does cyclophilin mean?
TY - JOUR. T1 - Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?. AU - Sigal, N. H.. AU - Dumont, F.. AU - Durette, P.. AU - Siekierka, John. AU - Peterson, L.. AU - Rich, D. H.. AU - Dunlap, B. E.. AU - Staruch, M. J.. AU - Melino, M. R.. AU - Koprak, S. L.. AU - Williams, D.. AU - Witzel, B.. AU - Pisano, J. M.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In this report we have approached two questions relating to the mechanism of action of cyclosporin A (CsA). First, we address whether the major cytosolic protein for CsA, cyclophilin, is directly involved in mediating the immunosuppressive activity of this drug, and, in particular, whether inhibition of this proteins peptidyl-prolyl cis-trans isomerase (PPIase) activity results in inhibition of murine T cell activation. Second, we ask whether the nephrotoxicity observed with CsA is related to inhibition of PPIase-dependent pathways in cells other than lymphocytes. Using a series of 61 cyclosporin ...
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA probably interacts directly with nonstructural protein 5A to exert its effect, through its peptidyl-prolyl isomerase activity, on maintaining the proper structure and function of the HCV replicase. The major proline substrates are located in domain II of NS5A, centered around a
The mitochondrial permeability transition pore (PTP) has been established as an important mediator of ischemia-reperfusion-induced cell death. The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. Therefore, the authors hypothesized that isoflurane, by inhibiting the re...
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of ...
Due to the increase of antifungal drug resistance and difficulties associated with drug administration, new antifungal agents for invasive fungal infections are needed. SCY-247 is a second-generation fungerp antifungal compound that interferes with the synthesis of the fungal cell wall polymer β-(1,3)-d-glucan. We conducted an extensive antifungal screen of SCY-247 against yeast and mold strains compared with the parent compound ibrexafungerp (IBX; formerly SCY-078) to evaluate the in vitro antifungal properties of SCY-247. SCY-247 demonstrated similar activity to IBX against all of the organisms tested. Moreover, SCY-247 showed a higher percentage of fungicidal activity against the panel of yeast and mold isolates than IBX. Notably, SCY-247 showed considerable antifungal properties against numerous strains of Candida auris. Additionally, SCY-247 retained its antifungal activity when evaluated in the presence of synthetic urine, indicating that SCY-247 maintains activity and structural ...
To find and calibrate a robust and reliable computational protocol for mapping conformational space of medium-sized molecules, exhaustive conformational sampling has been carried out for the series of seven macrocyclic compounds of varying ring size and one acyclic analogue. While five of them were taken from the MD/LLMOD/force-field study by Shelley and coworkers (J. Chem. Inf. MODEL: 2014, 54, 2680), three represent potential macrocyclic inhibitors of human cyclophilin A. The free energy values (GDFT/COSMO-RS) for all conformers of each compound were obtained by the composite protocol based on the in vacuo quantum mechanics (DFT-D3 method in a large basis set), standard gas-phase thermodynamics and the COSMO-RS solvation model (QM+COSMO-RS ...
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet …
3RCL: Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
ProSpecs Cyclophilins include: Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant
PPIL1 antibody [N1C3] (peptidylprolyl isomerase (cyclophilin)-like 1) for ICC/IF, WB. Anti-PPIL1 pAb (GTX118126) is tested in Human samples. 100% Ab-Assurance.
ARZNEIMITTELENTWICKLUNG + ARZNEIMITTELDESIGN + ARZNEIMITTELENTDECKUNG; ORGANISCHE SYNTHESE (CHEMIE); PEPTIDYLPROLYL-ISOMERASE, CYCLOPHILIN (ENZYME); ENZYMINHIBITOREN (BIOCHEMIE); DRUG DEVELOPMENT + DRUG DESIGN + DRUG DISCOVERY (PHARMACY); ORGANIC SYNTHESIS (CHEMISTRY); PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN (ENZYMES); ENZYME INHIBITORS (BIOCHEMISTRY ...
Cyclophilin-D Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 178 aa having a molecular mass of 18.9kDa.
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Keywords: HIV; Herpes; Host Factors; Host-Pathogen Interactions; Innate Immunity; Infection; Viruses; Restriction; Cyclophilin; TRIM5; Tetherin; Tropism; Gene ...
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1-(4-hydroxy-3-methoxyphenyl)propan-1-one 1835-14-9 NMR spectrum, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one H-NMR spectral analysis, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one C-NMR spectral analysis ect.
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis-trans isomerases (PPIases). Our earlier in silico based approach resulted into the identification of cyclophilin family from rice, Arabidopsis and yeast. In our recent report, we discovered a new OsCYP-25 from rice. Here, we identified a novel cyclophylin A-like protein (PiCyP) from Piriformospora indica which is responsible for abiotic stress tolerance in E. coli. Cyclophylin A-like protein (CyPA) (accession number GQ214003) was selected from cDNA library. The genomic organization CyPA revealed a 1304 bp of CyPA in P. indica genome, showing 10 exons and 9 introns. Further, CyPA was evident in PCR with gDNA and cDNA and Southern blot analysis. The phylogenetic examination of CyPA of P. indica showed that it is closed to human cyclophilin. The uniqueness of PiCyPA protein was apparent in western blot
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Rat CYPB(Cyclophilin B) ELISA Kit based in Delhi, India
TY - JOUR. T1 - Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin. AU - Cirillo, Raffaele. AU - Triggiani, Massimo. AU - Siri, Lorenzo. AU - Ciccarelli, Anna. AU - Pettit, George. AU - Condorelli, Mario. AU - Marone, Gianni. PY - 1990. Y1 - 1990. N2 - We have examined the effects of cyclosporin A (CsA) and a series of CsA analogs that bind with decreasing affinity to cyclophilin, to evaluate the involvement of this protein in the release of preformed (histamine) and de novo synthesized (peptide leukotriene C4; LTC4) mediators of inflammatory reactions from human basophils. CsA (8 to 800 nM) concentration-dependently inhibited (5 to 60%) histamine release from peripheral blood basophils challenged with anti-IgE. CsA was more potent (92.6 ± 1.8 vs 59.1 ± 4.5%; p , 0.001) and, at low concentrations, more effective when the channel-operated influx of Ca2+ as bypassed by the ionophore A23187 (IC40 = 24.1 ± 3.9 vs 105.5 ± 22.2 nM; p , ...
Cyclophilin antibody for detecting human peptidyl-prolyl cis-trans isomerase A. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
Molecular Plant-Microbe Interactions 14:1384-1394...Katarzyna Nuc , 1 Przemysław Nuc , 1 , 2 and Ryszard Słomski 1...© 2001 The American Phytopathological Society...Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an intronless gene coding for cytosolic CyP have been isolated from yellow lupine. The deduced amino acid sequence of the characterized open reading frame shows approximately 80% homol...
Cyclophilin B, 0.1 ml. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
A validated positive silencing control targeting the Cyclophilin B (PPIB) gene in human, mouse, or rat cell lines. Useful for determination of optimal RNAi experimental conditions
Figure 3. Genetically encoded N-epsilon lysine acetylation allows the high resolution X-ray structures of acetylated proteins and their complexes to be solved. The high resolution structure of acetyl lysine from acetylated cyclophilin (left) showing the experimental density. Right, Acetylated cyclophilin in complex with cyclosporine. Water molecules (blue spheres) that are ordered at the protein small molecule interface in the unacetylated complex) rearrange in the acetylated complex.. The acetylation of a cyclophilin at Lys125 was identified in a proteomics screen. We subsequently demonstrated that a substantial proportion of CYPA is acetylated in HeLa cells and human T cell lines, suggesting that the acetylated form of the protein is biologically relevant. To test this, recombinant CYPA bearing homogenous acetylation at Lys125 was prepared by overexpression in E. coli using an acetyllysyl-tRNA synthetase-tRNACUA pair, allowing detailed biophysical and enzymatic characterization of acetylated ...
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
Mast cells were purified from human skin of healthy donors according to our routine protocol (e.g. PMID: 14634065, 15191551, 15666093, 15675967, 20545757, 24671954, 25725371, 26706922, 28264498, 28845295, 28859248), reaching 98-100% purity, and transfected with siRNA as specified by the Dharmacon; all siRNAs were used at 1 µM. (A) Cellular uptake of siRNA, as measured by fluorescence microscopy using PE-labeled (non-targeting) siRNA (24 h after transfection). (B) and (C) relative gene expression in cells transfected with non-targeting siRNA versus siRNA targeting either GAPDH or Cyclophilin B, measured by RT-qPCR (48 h post-transfection) and normalized to control expression given as 1. Mean ± SEM of n = 6-9 individual experiments. Note that the knockdown was both highly efficient and specific, as only the targeted RNA was downregulated, while the Cyclophilin B-specific siRNA had no impact on GAPDH expression and vice versa. ** p , 0.01; *** p , 0.01; ****p , 0.0001 by Kruskal-Wallis test with ...
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ppiase, cyp37, peptidyl-prolyl, cis-trans, isomerase, cyp37, chloroplastic, PPIase CYP37 | peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic, P82869, ABF57273.1, AS10 1589
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Drug-induced mitochondrial dysfunction has been implicated in many types of organ toxicity, including liver and intestine. The induction of the mitochondrial permeability transition (mPT) has been seen as a mechanism of this toxicity. The mitochondrial matrix protein cyclophilin D (CypD) is a key regulator of the mPT, lending itself as a potential target for therapeutic intervention. The overall aim of this research project is to explore the mPT as a potential mediator of drug-induced mitochondrial toxicity in intestine and liver. Small intestinal ulceration is a frequent and serious adverse effect associated with the use of non-steroidal anti-inflammatory drugs. Mitochondria have been implicated in ulcer development. We have shown that inhibition of the mPT pore by pharmacologic blockade of CypD resulted in significant protection from diclofenac injury in cultured enterocytes and a 70% reduction in intestinal ulcers in mice. Furthermore, Ppif-/- (the gene encoding CypD) mice show 80% ulcer reduction
article{203b97eb-96fd-4fd8-a31f-dd57ba747ae5, abstract = {,p,Mitochondria control bioenergetics and cell fate decisions, but how they influence nuclear gene expression is understood poorly. Here, we show that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator, results in increased cell proliferation and enhanced cell migration and invasion. These responses are associated with extensive transcriptional changes, modulation of a chemokine/chemokine receptor gene signature, and activation of the pleiotropic inflammatory mediator, STAT3. In the absence of CypD, active STAT3 enhances cell proliferation via accelerated entry into S-phase and stimulates autocrine/paracrine cell motility through Cxcl12-Cxcr4-directed chemotaxis. Therefore, CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells. This pathway may contribute to malignant traits under conditions of CypD ...
Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI. The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. CAMLG has been shown to interact with TNFRSF13B. GRCh38: Ensembl release 89: ENSG00000164615 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021501 - Ensembl, May 2017 Human PubMed Reference:. Mouse ...
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Peptidyl-prolyl Cis-trans Isomerase (cyclophilin); Catalyzes The Cis-trans Isomerization Of Peptide Bonds N-terminal To Proline Residues; Plays A Role In Determining Prion Variants; Binds To Hsp82p And Contributes To Chaperone Activity; Protein Abundance Increases In Response To DNA Replication Stress
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Polyclonal antibody for Cyclophilin B/PPIB detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Cyclophilin B/PPIB information: Molecular Weight: 23743 MW; Subcellular Localization: Endoplasmic reticulum lumen. Me
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
2004). Patz EF Jr: Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. Lung Cancer ...
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway - Order reprints #922979
This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party ...
Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N, Neagu MR, Nilsson M, Eriksson PS, Hagberg H, Luban J, Kroemer G, Blomgren K. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med. 2007 Aug 6; 204(8):1741-8 ...
Deposition date: 2017-06-22 Original release date: 2018-02-02. Authors: Acevedo, Lucila; Nicholson, Linda. Citation: Acevedo, Lucila; Nicholson, Linda. 1H, 13C and 15N NMR assignments of cyclophilin LRT2 (OsCYP2) from rice Biomol. NMR Assignments 12, 171-174 (2018).. Assembly members: ...
7) X. Pang, M. J. Zhang, L. X. Zhou, F. Xie, H. Lu, W. He, S. B. Jiang, L. Yu and X. Y. Zhang. (2011) Discovery of a Potent Peptidic Cyclophilin A Inhibitor Trp-Gly-Pro. European Journal of Medicinal Chemistry. 46, 1701- ...
A stable, fluorescent positive control suitable for RNAi experiments in human, mouse, or rat cells Silences the Cyclophilin B gene and is labeled with DY-547
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The Role of Cyclophilin D in learning and memory. Brush, F. Robert (2003). "Selection for Differences in avoidance Learning: ...
... cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair was ... The bumped cyclosporin A was found to interact efficiently with the hole-modified cyclophilin mutant, but not endogenous ... cyclophilin. The orthogonal CID pair was used to inhibit calcineurin-mediated dephosphorylation of nuclear factor of activated ... engineered to improve the binding efficiency between wild type cyclosporin A and cyclophilin, thereby giving more efficient CID ...
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ... Cyclosporin binds to the cytosolic protein Peptidyl-prolyl cis-trans isomerase A (known as cyclophilin), while tacrolimus binds ...
Mice lacking the gene for cyclophilin-D develop normally, but their cells do not undergo Cyclosporin A-sensitive MPT, and they ... "Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death". Nature. 434 (7033): 658 ... "Complex Contribution of Cyclophilin D to Ca2+-induced Permeability Transition in Brain Mitochondria, with Relation to the ... "Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death". Nature. ...
Larson, T. G.; Nuss, D. L. (1 January 1993). "Cyclophilin-dependent stimulation of transcription by cyclosporin A." Proceedings ...
1997). "A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II". Nucleic ...
... binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin". ...
Inhibiting cyclophilin D has been shown to prevent the opening of the MPT pore and protect the mitochondria and cellular energy ... Cyclosporin has been confirmed in studies to inhibit the actions of cyclophilin D, a protein which is induced by excessive ...
... and the matrix protein cyclophilin D (CyD) (12). This pore causes the mitochondria to swell and the outer mitochondrial ...
... and contain full-length Cyclophilin and FKBP chaperone modules. The evolutionary origin of such chimera remains unclear. ...
ISO 4217 code for the Cypriot pound Cyclophilin Cytochrome P450, isoenzyme Cypripedium, orchid genus This disambiguation page ...
CsA binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, which can ... This ciclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of ... Ciclosporin also binds to the cyclophilin D protein that constitutes part of the mitochondrial permeability transition pore ( ... Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding ...
2001). "CD147 is a signaling receptor for cyclophilin B". Biochem. Biophys. Res. Commun. 288 (4): 786-8. doi:10.1006/bbrc. ... 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". J. Biol. Chem. 277 (25): 22959 ... Yurchenko V, O'Connor M, Dai W, Guo H, Toole B, Sherry B, Bukrinsky M (2001). "CD147 is a signaling receptor for cyclophilin B ... including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.[11][12][13] It is expressed by many cell types ...
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). „Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
Ciclosporin is thought to bind to the cytosolic protein cyclophilin (an immunophilin) of immunocompetent lymphocytes, ... This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin, which under normal circumstances induces the ...
Machida K, Ohta Y, Osada H (May 2006). "Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II ...
Yurchenko V, O'Connor M, Dai W, Guo H, Toole B, Sherry B, Bukrinsky M (2001). "CD147 is a signaling receptor for cyclophilin B ... "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". J Biol Chem 277 (25): 22959-65. PMID ... "Dealing with the family: CD147 interactions with cyclophilins". Immunology 117 (3): 301-9. PMC 1782239. PMID 16476049. doi ...
... cyclophilin-40, PP5, Tom70, and many more. The Hsp90 protein contains three functional domains, the ATP-binding, protein- ...
... and cyclophilin inhibitors.[58] These potentially new treatments have come about due to a better understanding of the hepatitis ...
... and cyclophilin B". J. Biol. Chem. (United States) 278 (9): 7459-68. ISSN 0021-9258. PMID 12397072. doi:10.1074/jbc.M207976200. ...
Members of every class of pathogen that infect humans also infect plants. Although the exact pathogenic species vary with the infected species, bacteria, fungi, viruses, nematodes, and insects can all cause plant disease. As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses which lead to the formation of defensive chemical compounds that fight infection or make the plant less attractive to insects and other herbivores.[33] (see: plant defense against herbivory). Like invertebrates, plants neither generate antibody or T-cell responses nor possess mobile cells that detect and attack pathogens. In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that very few animals are able to do. Walling off or discarding a part of a plant helps stop spread of an infection.[33] Most plant immune responses involve systemic chemical signals sent throughout a plant. Plants use pattern-recognition receptors to ...
Immunophilins (Cyclophilin). This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it. * ...
Testa L, Van Gaal WJ, Bhindi R, Biondi-Zoccai GG, Abbate A, Agostoni P, et al. (October 2008). "Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients". The Journal of Thoracic and Cardiovascular Surgery. 136 (4): 884-93. doi:10.1016/j.jtcvs.2007.12.062. PMID 18954626 ...
... was the first fully human monoclonal antibody approved by the US Food and Drug Administration (FDA).[34] It was derived from phage display.[34][35] Adalimumab was discovered as a result of a collaboration between BASF Bioresearch Corporation and Cambridge Antibody Technology, U.K., itself a collaboration of the government-funded Medical Research Council and three academics, which began in 1993.[34][36] Initially named D2E7,[37] it was then further manufactured at BASF Bioresearch Corporation, developed by BASF Knoll (BASF Pharma), and ultimately manufactured and marketed by Abbott Laboratories after Abbott's acquisition of BASF Pharma. On 1 January 2013, Abbott split into two companies, one retaining the Abbott name and the other named AbbVie.[38] As a result, AbbVie took over development and marketing of Humira.[39][40] The brand name Humira stands for "human monoclonal antibody in rheumatoid arthritis", and was named by one of Abbott's employees, Richard J. Karwoski, who was also ...
As of January 2007[update], there were 5 NIH-listed research studies involving CNTO 1275 on a multinational basis, including 3 Phase II and 2 Phase III trials. Three studies were focused on patients with psoriasis, one on psoriatic arthritis, and one on multiple sclerosis. On December 4, 2007, a Biologic License Application (BLA) with the U.S. Food and Drug Administration (FDA) was filed by Centocor and Janssen-Cilag International (collaborator) has submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMEA). On November 21, 2008, the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for ustekinumab for the treatment of moderate to severe plaque psoriasis in adult patients who failed to respond to other systemic therapies.[10] ...
The patent on Enbrel was originally set to expire on October 23, 2012,[28] but, in the United States, a second patent, granting exclusivity for another 16 years, has been granted.[29] Before the extension it seemed unlikely that a generic would have been available. As a biologic, etanercept is subject to different laws from those applicable to chemical formulations. Currently many countries do not permit the manufacture of generic biologics. However, the European Union and the United States (Biologics Price Competition and Innovation Act of 2009) do currently have in place a system to approve generic biologics (biosimilars) which "requires mandatory clinical testing and periodic review".[30] In April 2013, the Indian pharma major Cipla made an announcement about launching the first biosimilar of Etanercept in India under the brand name 'Etacept' for the treatment of rheumatic disorders. The company's April 17, 2013 press release claimed that the biosimilar will cost 30% less as compared to the ...
Nakamura, M; Tanaka, Y; Satoh, T; Kawai, M; Hirakata, M; Kaburaki, J; Kawakami, Y; Ikeda, Y; Kuwana, M (2006). "Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism". Rheumatology (Oxford, England). 45 (2): 150-6. doi:10.1093/rheumatology/kei118. PMID 16188945 ...
... is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that consists of mouse heavy and light chain variable regions combined with human heavy and light chain constant regions.[25] It has a serum half-life of 9.5 days and can be detected in serum 8 weeks after infusion treatment.[25] Infliximab neutralizes the biological activity of TNF-α by binding with high affinity to the soluble (free floating in the blood) and transmembrane (located on the outer membranes of T cells and similar immune cells) forms of TNF-α, and inhibits or prevents the effective binding of TNF-α with its receptors. Infliximab and adalimumab (another TNF antagonist) are in the subclass of "anti-TNF antibodies" (they are in the form of naturally occurring antibodies), and are capable of neutralizing all forms (extracellular-, transmembrane-, and receptor-bound) TNF-α.[26] Etanercept, a third TNF antagonist, is in a different subclass (receptor-construct fusion protein), and, because ...
Cyclophilins (Cyps) are a major family of drug targets that are challenging to prosecute with small molecules because the ... Cyclophilins (Cyps) are a major family of drug targets that are challenging to prosecute with small molecules because the ... A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors.. De Simone, A. ... Cyclophilin A complexed with tri-vector ligand 4.. *DOI: 10.2210/pdb6GJM/pdb ...
Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice. ... Background: Cyclophilin A (CyPA, encoded by Ppia) is a ubiquitously expressed protein secreted in response to pro-inflammatory ... Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice ... Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice ...
"ウサギ・ポリクローナル抗体 ab3562 交差種: Ms,Rat,Rb,Chk,Cow,Hu,NHuPrm 適用: WB,IP,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…Cyclophilin… ... Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.. Contains 1 PPIase cyclophilin-type domain.. Contains 3 TPR ... Anti-Cyclophilin 40 antibody. Cyclophilin 40 一次抗体 製品一覧. ... Detects cyclophilin 40 (CyP 40) from Human and Rat tissues and cells. This antibody does not cross-react with CyPA. ...
Cyclophilin A (CypA) is an abundant cellular protein known to bind the N-terminal domain of the capsid protein. CypA can ... Regulation of HIV-1 Host Factor Interactions by Cyclophilin A Burse, Mallori Jacole Vanderbilt University Medical Center, ... Regulation of HIV-1 Host Factor Interactions by Cyclophilin A. Burse, Mallori Jacole / Vanderbilt University Medical Center. ... Regulation of HIV-1 Host Factor Interactions by Cyclophilin A. Burse, Mallori Jacole / Vanderbilt University Medical Center. $ ...
The host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral ...
Researchers at the University of Rochester Medical Center in New York said removing the gene that makes the protein cyclophilin ... He said cyclophilin A encourages the production of harmful compounds known as reactive oxygen species, which trigger cells to ... From this group, they bred mice that lacked cyclophilin A. All were treated with angiotensin II, which is known to raise blood ... While 78 percent of mice with normal amounts of the cyclophilin A developed aortic aneurysms, none of the mice who lacked the ...
Rotamase The first cyclophilin (Cyp/PPIases: EC 5.2.1.8) was isolated more than three decades ago as an... ... Cyclophilin-like domain (CLD); Immunophilin; Peptidyl prolyl cis trans isomerase; PPIase; ... The single domain cyclophilin has a single cyclophilin-like domain (CLD), whereas multidomain cyclophilins also possess ... Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009;284:9692-9.CrossRefPubMedPubMedCentral ...
The authors suggest that cyclophilin A (CypA), a component of the APOE4-activated pathway, is a potential target for treating ... Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that ... Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24, 1186-1191 ( ... Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nature Med. 15 ...
PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL1-(4-Aminobenzyl)-3-(2-{(2r)-2-[2-(Methylsulfanyl)phenyl]pyrrolidin-1-Yl}-2-Oxoethyl)urea
cyclophilin. A. 229. Plasmodium yoelii yoelii. Mutation(s): 0 Gene Names: PY00382. EC: 5.2.1.8. ...
Mouse monoclonal Cyclophilin A antibody. Validated in WB, IP, Flow Cyt, ICC/IF and tested in Human. Cited in 14 publication(s ... Cyclophilin A was immunoprecipitated using 0.5mg Hela whole cell extract, 10µg of Mouse monoclonal to Cyclophilin A and 50µl of ... Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.. Contains 1 PPIase cyclophilin-type domain. ... Primary - Mouse Anti-Cyclophilin A antibody (ab58144) WB, ICC/IF, IP, Flow Cyt ...
Rabbit polyclonal Cyclophilin B antibody. Validated in WB, IP, IHC, ICC/IF and tested in Mouse, Rat, Horse, Chicken, Dog, Human ... Human Cyclophilin B peptide (ab16277) at 1 µg/ml. Lane 7 : HeLa whole cell lysate with Human Cyclophilin B peptide (ab16277) at ... Human Cyclophilin B peptide (ab16277) at 1 µg/ml. Lane 9 : Jurkat whole cell lysate with Human Cyclophilin B peptide (ab16277) ... Anti-Cyclophilin B antibody (ab16045) at 0.5 µg/ml + Recombinant Human Cyclophilin B protein (ab88801) at 0.01 µg. Secondary. ...
4 May 2017, by Kathrin Oppermann. The department of Molecular Plant Genetics has published a new research article: "Bioinformatic and expression analysis of the Brassica napus L. cyclophilins" in "Scientific Reports".. The full text article can be found here. ...
There are no specific protocols for Recombinant human Cyclophilin F protein (ab79186). Please download our general protocols ...
Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant ... Humans are thought to have around 16 of these cyclophilins.. Cyclophilin Function. The Cyclosporin Cyclophilin A complex ... About Cyclophilin:. Cyclophilins are known for their ability to bind ciclosporin, which is used to suppress rejection after a ... Cyclophilin Structure. Cyclophilin A has a beta barrel structure (two alpha helices and a beta sheet). There is usually a ...
... mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA ...
Browse our Cyclophilin C Antibody catalog backed by our Guarantee+. ... Our Cyclophilin C Antibodies can be used in a variety of model species: Human. Use the list below to choose the Cyclophilin C ... Alternate Names for Cyclophilin C Antibodies. anti-Cyclophilin C antibody, anti-PPIC antibody, anti-CYPCMGC3673 antibody, anti- ... Cyclophilin C Antibodies. We offer Cyclophilin C Antibodies for use in common research applications: ELISA, ...
... cyclophilin a include A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype ... Cyclophilin A: A 17-KDa cytoplasmic Peptidylprolyl isomerase involved in immunoregulation. It is a member of the cyclophilin ...
Generation of Rabbit Anti-Cyclophilin and Anti-AGE-Modified Cyclophilin Antisera.. Female New Zealand white rabbits were ... cyclophilin A;. CsA,. cyclosporin A;. PIC,. pre-integration complex;. CA,. capsid antigen;. AGE,. advanced glycosylation ... and 100 nmol of 125I-cyclophilin (either alone, or in combination with a 100-fold excess of cold cyclophilin) was added. After ... A receptor for another member of the cyclophilin family, cyclophilin B (CyPB), which is highly homologous to CyPA, has been ...
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.. Zhu D1, Wang Z2, Zhao JJ1, ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ... The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy ...
HIV-1 cyclophilin-binding mutants CA G89V and P90A favored integration in genomic regions with a higher density of ... HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency PLoS ... Here we report that HIV-1 capsid (CA) binds directly to the cyclophilin domain of Nup358/RanBP2. Fusion of the Nup358/RanBP2 ... Our findings link HIV-1 engagement of cyclophilins with both integration targeting and replication efficiency and provide ...
Cyclophilin A is a peptidyl-prolyl isomerase and is widely expressed in a multitude of tissues, but is present in highest ... Cyclophilin A is a small, soluble protein which binds the immunosuppressive drug cyclosporin A. ... The pattern of cyclophilin. A expression is consistent with a role of cyclophilin A in neuronal protein maturation and folding ... Cyclophilin A is a small, soluble protein which binds the immunosuppressive drug cyclosporin A. Cyclophilin A is a peptidyl- ...
13 antibodies to Cyclophilin A and validated for use in 6 applications (Immunohistochemistry,Flow Cytometry,Western Blot, ... cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p ... cyclophilin A); PPIase A; rotamase; Rotamase A; SP18; T cell cyclophilin ... Cyclophilin A Antibodies Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major ...
Validated positive control siRNA targeting the Cyclophilin B (PPIB) housekeeping gene in human, mouse, or rat Accell siRNA ... Accell Cyclophilin B Control siRNA Accell Cyclophilin B Control siRNA. Validated Accell positive controls provide a reliable ... Accell Cyclophilin B Control siRNA is modified with patent-pending Accell modification pattern to enable uptake by difficult-to ... Accell Cyclophilin B Control siRNA is validated, highly reliable positive control for delivery and RNAi efficiency. ...
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. ... Keywords: influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction influenza virus; Cyclophilin A; Cyclosporin A; ... This article belongs to the Special Issue Cyclophilins and Viruses) View Full-Text , Download PDF [274 KB, uploaded 12 May 2015 ... Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. ...
This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition ...
... is a fluorescent control reagent that provides highly reliable qualitative assessment ... SH-SY5Y cells were treated with 1 µM Accell Red Cyclophilin B Control siRNA in Accell delivery media. (Red fluorescence = ... In addition, it acts as a positive control targeting Cyclophilin B. Also known as peptidylprolyl isomerase B (PPIB), ... Accell Green Cyclophilin B Control siRNA. siRNA for difficult-to-transfect cells ...
A Cyclophilin Function in Hsp90-Dependent Signal Transduction. By Andrea A. Duina, Hui-Chen Jane Chang, James A. Marsh, Susan ... A Cyclophilin Function in Hsp90-Dependent Signal Transduction. By Andrea A. Duina, Hui-Chen Jane Chang, James A. Marsh, Susan ... A Cyclophilin Function in Hsp90-Dependent Signal Transduction Message Subject. (Your Name) has forwarded a page to you from ... Cpr6 and Cpr7, the Saccharomyces cerevisiae homologs of cyclophilin-40 (CyP-40), were shown to form complexes with Hsp90, a ...
Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding, R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding, R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues.. A J Koletsky, M W Harding and R E ... Cyclophilin: distribution and variant properties in normal and neoplastic tissues. Message Subject (Your Name) has forwarded a ...
Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin. By Gitta Coaker, Arnold Falick, Brian ... Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin. By Gitta Coaker, Arnold Falick, Brian ... AvrRpt2 is delivered into the plant cell, where it is activated by a eukaryotic factor that we identify as cyclophilin. This ... Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin Message Subject. (Your Name) has ...
Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an ... Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an ...
These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER ... cyclophilin B , peptidylprolyl isomerase B , peptidylprolyl isomerase B (cyclophilin B) , PPIase B , peptidyl-prolyl cis-trans ... anti-Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G Antikörper * anti-Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A ... Zusätzlich bieten wir Ihnen Peptidylprolyl Isomerase B (Cyclophilin B) Kits (62) und Peptidylprolyl Isomerase B (Cyclophilin B ...
Buy cyclophilin g antibodies from Santa Cruz Biotechnology, Inc. Monoclonal antibodies are available to most protein immunogens ... Additional Cyclophilin Antibodies including Cyclophilin E, Cyclophilin F, CyPA, CyPB and Cyclophilin 40 ... Cyclophilin G Antibodies. Santa Cruz Biotechnology, Inc. offers a broad range of Cyclophilin G antibodies. Select Cyclophilin G ... View detailed Cyclophilin G antibody specifications by linking to the specific product blocks. Select appropriate Cyclophilin G ...
Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some ... Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest ... Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally ...
... including cyclophilin D oxidative modifications, and reverses cyclophilin D induction in vitro and in vivo. These findings ... Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.. [Jone López- ... Moreover, we show increased expression levels of cyclophilin D in the affected zones of brains in patients with ... Among the mitochondrial permeability transition pore components, cyclophilin D is the most studied and has been found increased ...
  • Researchers at the University of Rochester Medical Center in New York said removing the gene that makes the protein cyclophilin A protected mice genetically predisposed to developing aneurysms. (healthmanagement.org)
  • 6GJM: Cyclophilin A complexed with tri-vector ligand 4. (rcsb.org)
  • Dr. Bradford Berk, who led the study, said the cyclophilin A protein may offer a highly targeted way of preventing this process. (healthmanagement.org)
  • Berk thinks angiotensin II unlocks cyclophilin A, which causes a lot of the damage. (healthmanagement.org)
  • To understand what role cyclophilin A plays, Berk and colleagues used mice bred to be predisposed to high cholesterol and high blood pressure. (healthmanagement.org)
  • It is extremely unusual for the removal of one protein to provide absolute protection, but it makes perfect sense because cyclophilin A promotes three of the most destructive forces in blood vessels -- oxidative stress, inflammation and matrix degradation," Berk said in a statement. (healthmanagement.org)
  • He said cyclophilin A encourages the production of harmful compounds known as reactive oxygen species, which trigger cells to self-destruct. (healthmanagement.org)

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