AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Cyclophilin ACyclophilinsPeptidylprolyl IsomeraseAmino Acid IsomerasesCyclosporineImmunophilinsCyclosporinsCarrier ProteinsAntigens, CD147Mitochondrial Membrane Transport ProteinsTransmembrane Activator and CAML Interactor ProteinTacrolimus Binding ProteinsMolecular Sequence DataAotidaeAmino Acid SequenceCalcineurinTumor Necrosis Factor Ligand Superfamily Member 13Protein BindingHIV-1ProlineAstheniaSpiro CompoundsSubtilisinVirus ReplicationSequence Homology, Amino AcidB-Cell Maturation AntigenHippocastanaceaeAdenine Nucleotide Translocator 1TacrolimusMitochondriaOxazepinesVirionGene Products, gagCell LineHSP90 Heat-Shock ProteinsIsomerismCalmodulin-Binding ProteinsModels, MolecularImmunosuppressive AgentsChloroplast ThioredoxinsB-Cell Activating FactorMembrane Potential, MitochondrialBase SequenceBinding SitesMolecular ChaperonesLuteoviridaeCloning, MolecularCercopithecidaeRecombinant ProteinsProtein ConformationProtein FoldingMitochondrial Membranes
Cyclophilin A
A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.
Cyclophilins
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
Peptidylprolyl Isomerase
An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.
Amino Acid Isomerases
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
Cyclosporine
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Immunophilins
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Cyclosporins
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Antigens, CD147
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Mitochondrial Membrane Transport Proteins
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
Transmembrane Activator and CAML Interactor Protein
A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.
Tacrolimus Binding Proteins
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Aotidae
A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Calcineurin
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Tumor Necrosis Factor Ligand Superfamily Member 13
A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
HIV-1
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
Proline
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Asthenia
Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.
Spiro Compounds
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
Subtilisin
A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. It also hydrolyzes peptide amides. (From Enzyme Nomenclature, 1992) EC 3.4.21.62.
Virus Replication
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
B-Cell Maturation Antigen
A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Hippocastanaceae
A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.
Adenine Nucleotide Translocator 1
A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
Tacrolimus
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Oxazepines
Virion
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Gene Products, gag
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
HSP90 Heat-Shock Proteins
A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
Isomerism
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Calmodulin-Binding Proteins
Proteins which bind calmodulin. They are found in many tissues and have a variety of functions including F-actin cross-linking properties, inhibition of cyclic nucleotide phosphodiesterase and calcium and magnesium ATPases.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Chloroplast Thioredoxins
A subtype of thioredoxins found primarily in CHLOROPLASTS.
B-Cell Activating Factor
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
Membrane Potential, Mitochondrial
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Molecular Chaperones
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
Luteoviridae
A family of RNA plant viruses infecting disparate plant families. They are transmitted by specific aphid vectors. There are three genera: LUTEOVIRUS; Polerovirus; and Enamovirus.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Cercopithecidae
The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Protein Folding
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Mitochondrial Membranes
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).

Cyclophilin A is a secreted growth factor induced by oxidative stress. (1/314)

Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis, hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. Many VSMC growth factors are secreted by VSMC and act in an autocrine manner. Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal-regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Human recombinant CyPA can mimic the effects of secreted CyPA to stimulate ERK1/2 and cell growth. The peptidyl-prolyl isomerase activity is required for ERK1/2 activation by CyPA. In vivo, CyPA expression and secretion are increased by oxidative stress and vascular injury. These findings are the first to identify CyPA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases.  (+info)

Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (2/314)

The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. To determine whether CypA promotes HIV-1 replication, we deleted the gene encoding CypA (PPIA) in human CD4(+) T cells by homologous recombination. HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific for wild-type HIV-1 since HIV-2/SIV isolates, as well as HIV-1 bearing a gag mutation that confers cyclosporin resistance, replicated the same in PPIA(+/+) and PPIA(-/-) cells. Stable re-expression of CypA in PPIA(-/-) cells restored HIV-1 replication to an extent that correlated with steady-state levels of CypA. Finally, virions from PPIA(-/-) cells possessed no obvious biochemical abnormalities but were less infectious than virions from wild-type cells. These data formally demonstrate that CypA regulates the infectivity of HIV-1 virions.  (+info)

Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. (3/314)

Caveolin-1 is a palmitoylated protein involved in assembly of signaling molecules in plasma membrane subdomains termed caveolae and in intracellular cholesterol transport. Three cysteine residues in the C terminus of caveolin-1 are subject to palmitoylation, which is not necessary for caveolar targeting of caveolin-1. Protein palmitoylation is a post-translational and reversible modification that may be regulated and that in turn may regulate conformation, membrane association, protein-protein interactions, and intracellular localization of the target protein. We have undertaken a detailed analysis of [(3)H]palmitate incorporation into caveolin-1 in aortic endothelial cells. The linkage of palmitate to caveolin-1 was hydroxylamine-sensitive and thus presumably a thioester bond. However, contrary to expectations, palmitate incorporation was blocked completely by the protein synthesis inhibitors cycloheximide and puromycin. In parallel experiments to show specificity, palmitoylation of aortic endothelial cell-specific nitric-oxide synthase was unaffected by these reagents. Inhibitors of protein trafficking, brefeldin A and monensin, blocked caveolin-1 palmitoylation, indicating that the modification was not cotranslational but rather required caveolin-1 transport from the endoplasmic reticulum and Golgi to the plasma membrane. In addition, immunophilin chaperones that form complexes with caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary for caveolin-1 palmitoylation because agents that bind immunophilins did not inhibit palmitoylation. Pulse-chase experiments showed that caveolin-1 palmitoylation is essentially irreversible because the release of [(3)H]palmitate was not significant even after 24 h. These results show that [(3)H]palmitate incorporation is limited to newly synthesized caveolin-1, not because incorporation only occurs during synthesis but because the continuous presence of palmitate on caveolin-1 prevents subsequent repalmitoylation.  (+info)

Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein. (4/314)

While several cellular proteins are incorporated in the human immunodeficiency virus type 1 virion, cyclophilin (CyP) A is the only one whose absence has been demonstrated to impair infectivity. Incorporation of the cytosolic protein results from interaction with a highly exposed Pro-rich loop in the N-terminal region of the capsid (CA) domain of the precursor polyprotein, Pr55(Gag). Even when prevented from interacting with CyP A, Pr55Gag still forms particles that proceed to mature into morphologically wild-type virions, suggesting that CyP A influences a postassembly event. The nature of this CyP A influence has yet to be elucidated. Here, we show that while CyP A binds both Gag and mature CA proteins, the two binding interactions are actually different. Tryptophan 121 (W121) in CyP A distinguished the two proteins: a phenylalanine substitution (W121F) impaired binding of mature CA protein but not of Gag. This indicates the occurrence of a maturation-dependent switch in the conformation of the Pro-rich loop. A structural consequence of Gag binding to CyP A was to block this maturational refolding, resulting in a 24-kDa CA protein retaining the immature Pro-rich loop conformation. Using trypsin as a structure probe, we demonstrate that the conformation of the C-terminal region in mature CA is also a product of maturational refolding. Binding to wild-type CyP A altered this conformation, as indicated by a reduction in the accessibility of Cys residue(s) in the region to chemical modification. Hence, the end result of binding to CyP A, whether the Pro-rich loop is in the context of Gag or mature CA protein, is a structurally modified mature CA protein. The postassembly role of CyP A may be mediated through these modified mature CA proteins.  (+info)

Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle. (5/314)

Sanglifehrin A (SFA) is a novel immunosuppressive natural product that binds to cyclophilin but is structurally distinct from cyclosporin A (CsA). We have investigated the cellular and molecular mechanisms of the action of SFA in T lymphocytes. We show that SFA inhibits T cell proliferation induced by IL-2 with an IC(50) of 200 nM. Distinct from CsA, which also binds to cyclophilin, SFA does not affect calcium-dependent IL-2 production, although SFA enhanced IL-2 gene transcription in the same cells. SFA blocks T cell proliferation induced by IL-2 in G(1) with no appreciable effect on IL-2 receptor expression in a manner similar to that of the immunosuppressant rapamycin. Unlike rapamycin, however, SFA has no effect on the phosphorylation or enzymatic activity of p70(s6k) kinase, distinguishing SFA from rapamycin in their mode of action. SFA inhibits hyperphosphorylation of Rb and the activity of cyclin E-cyclin-dependent kinase 2 on IL-2 signaling. These results suggest that SFA has a novel mode of action in comparison with CsA, FK506, and rapamycin, and that its use as a molecular probe may lead to the discovery of a novel target involved in T cell activation.  (+info)

CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. (6/314)

Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies implicated CD147 as a receptor for extracellular CyPA. Here, we demonstrate a role for CyPA-CD147 interaction during the early steps of HIV-1 infection. Expression of human CD147 increased infection by HIV-1 under one-cycle conditions. However, susceptibility to infection by viruses lacking CyPA (simian immunodeficiency virus or HIV-1 produced in the presence of cyclosporin A) was unaffected by CD147. Virus-associated CyPA coimmunoprecipitated with CD147 from infected cells. Antibody to CD147 inhibited HIV-1 entry as evidenced by the delay in translocation of the HIV-1 core proteins from the membrane and inhibition of viral reverse transcription. Viruses whose replication did not require CyPA (SIV or mutant HIV-1) were resistant to the inhibitory effect of anti-CD147 antibody. These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell.  (+info)

A partially folded intermediate species of the beta-sheet protein apo-pseudoazurin is trapped during proline-limited folding. (7/314)

The folding of apo-pseudoazurin, a 123-residue, predominantly beta-sheet protein with a complex Greek key topology, has been investigated using several biophysical techniques. Kinetic analysis of refolding using far- and near-ultraviolet circular dichroism (UV CD) shows that the protein folds slowly to the native state with rate constants of 0.04 and 0.03 min(-1), respectively, at pH 7.0 and at 15 degrees C. This process has an activation enthalpy of approximately 90 kJ/mole and is catalyzed by cyclophilin A, indicating that folding is limited by trans-cis proline isomerization, presumably around the Xaa-Pro 20 bond that is in the cis isomer in the native state. Before proline isomerization, an intermediate accumulates during folding. This species has a substantial signal in the far-UV CD, a nonnative signal in the near-UV CD, exposed hydrophobic surfaces (judged by 1-anilino naphthalenesulphonate binding), a noncooperative denaturation transition, and a dynamic structure (revealed by line broadening on the nuclear magnetic resonance time scale). We compare the properties of this intermediate with partially folded states of other proteins and discuss its role in folding of this complex Greek key protein.  (+info)

Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. (8/314)

Six distinct peroxiredoxin (Prx) proteins (Prx I-VI) from distinct genes have been identified in mammalian tissues. Prxs are members of a group of peroxidases that have conserved reactive cysteine residue(s) in the active site(s). An immediate physiological electron donor for the peroxidase catalysis for five Prx proteins (Prx I-V) has been identified as thioredoxin (Trx), but that for Prx VI (1-Cys Prx) is still unclear. To identify an immediate electron donor and a binding protein for Prx VI, we performed a Prx VI protein overlay assay. A 20-kDa binding protein was identified by the Prx VI protein overlay assay with flow-through fractions from a High-Q column with rat lung crude extracts. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and MS-Fit, we identified the 20-kDa Prx VI-binding protein as a cyclophilin A (CyP-A). The binding of recombinant human CyP-A (hCyP-A) to Prx VI was confirmed by using the hCyP-A protein overlay assay and Western immunoblot analysis with hCyP-A-specific antibodies. hCyP-A enhanced the antioxidant activity of Prx VI, as well as the other known mammalian Prx isotypes. hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems. Prx II was reduced by hCyP-A without help from any other reductant, and the reduction was cyclosporin A-independent. These results strongly suggest that CyP-A not only binds to Prx proteins but also supports its peroxidase activity as an immediate electron donor. In addition, Cys(115) and Cys(161) of hCyP-A were found to be involved in the activation and the reduction of Prx.  (+info)

Interaction of cyclophilin A with a novel binding protein, SR-25, and characterization of their expression pattern in Chinese...Interaction of cyclophilin A with a novel binding protein, SR-25, and characterization of their expression pattern in Chinese...
Cyclophilin (Cyp) A has been reported to be overexpressed in the majority of cancer cells, including hepatocellular carcinoma (HCC). However, the biological functions of CypA in HCC are far from being understood. To determine the biological functions of CypA in HCC, the present study screened human fetal liver complementary DNA for proteins interacting with CypA using the yeast two-hybrid system. A nuclear protein, serine/arginine-rich (SR)-25, was isolated as a novel CypA-binding protein that is distinct from those previously described in the literature. Binding assays and co-immunoprecipitation confirmed the physical association between CypA and SR-25. The present study demonstrated that CypA may interact with SR-25 through its peptidyl-prolyl isomerase domain. In addition, CypA may induce the expression of SR-25 in Hep3B cells. The messenger RNA levels of CypA and SR-25 in HCC indicated that there was a significant correlation between the expression of CypA and the expression of SR-25 in HCC. It can
https://www.semanticscholar.org/paper/Interaction-of-cyclophilin-A-with-a-novel-binding-Chen-Li/7dfd7ac0506d374cabb43f1073cfa6a88fb4c6c2
Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivityMechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity
Optimal HIV-1 infectivity requires the presence of both the viral factor Nef and the cellular protein cyclophilin A (CyPA) during virion assembly. These two proteins are integral components of HIV-1 particles. Both CyPA and Nef facilitate a step in the viral life cycle occurring between penetration …
https://pubmed.ncbi.nlm.nih.gov/9705263/?dopt=Abstract
Title page for ETD etd-12042017-090452
The host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral capsid (CA). CypA enhances the early stages of HIV-1 infection in part by promoting nuclear import of the virus; while the details of its ability to inhibit HIV-1 infection are less clear. This thesis advances our understanding of the mechanisms underlying the ability of CypA to inhibit HIV-1 infection. I demonstrate that CypA inhibits nuclear import of HIV-1 in the presence of inhibitory capsid-binding host proteins TRIM5α and CPSF6, and that inhibition is not a consequence of increased binding of inhibitory factors to the viral capsid. My work also demonstrates that CypA-dependent inhibition depends in part, on a conserved domain of HIV-1 CA which determines interactions with host nuclear pore proteins. These results suggest a common mechanism underlies the ability of CypA to stimulate HIV-1 infectivity in some cells and to inhibit infection in others. ...
http://etd.library.vanderbilt.edu/available/etd-12042017-090452/
Cyclophilin H / PPIH (1-177) - AR09072PU-L | acris-antibodies.com
Cyclophilin H / PPIH, 0.5 mg. Cyclophilin H (also known as peptidylpropyl isomerase H, PPIH) is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
https://www.acris-antibodies.com/proteins-growth-factors/cyclophilin-h-ppih-ar09072pu-l.htm
Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice |...Abstract 13067: Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice |...
Background: Cyclophilin A (CyPA, encoded by Ppia) is a ubiquitously expressed protein secreted in response to pro-inflammatory stimuli. CyPA stimulates VSMC migration and proliferation, endothelial cell adhesion molecule expression and inflammatory cell chemotaxis. Given these activities, we hypothesized that CyPA is pro-atherogenic.. Methods and Results: In the high cholesterol diet fed Apoe-/- mouse CyPA deficiency led to a reduction of atherosclerosis (% Oil Red O, en face aorta; 19.3±7.5 in Apoe-/- vs. 8.2±2.0 in Apoe-/-Ppia-/- mice, P,0.01). CyPA deficiency was associated with decreased LDL uptake, inflammatory cell accumulation, and apoptosis. Moreover, en face staining of aortic tissues showed that VCAM-1 expression was significantly reduced in mice lacking CyPA. Importantly, eNOS protein expression was significantly higher in the Apoe-/-Ppia-/- mice compared to Apoe-/- mice. To define the mechanisms responsible for decreased eNOS expression, the effect of altering CyPA levels in ...
http://circ.ahajournals.org/content/122/Suppl_21/A13067
Recombinant human Cyclophilin 40 protein (ab78815) ReferencesRecombinant human Cyclophilin 40 protein (ab78815) References
References for Abcams Recombinant human Cyclophilin 40 protein (ab78815). Please let us know if you have used this product in your publication
http://www.abcam.com/recombinant-human-cyclophilin-40-protein-ab78815-references.html
Recombinant Human Cyclophilin E protein (His tag) (ab206449) | AbcamRecombinant Human Cyclophilin E protein (His tag) (ab206449) | Abcam
Recombinant Human Cyclophilin E protein (His tag) is an Escherichia coli Full length protein 2 to 301 aa range, | 95% purity, | 1.000 Eu/µg endotoxin level and validated in SDS-PAGE, MS.
https://www.abcam.com/recombinant-human-cyclophilin-e-protein-his-tag-ab206449.html
Highlights of our Work
When human immundeficiency virus (HIV) infects a human cell, it releases into the interior of the cell its capsid (made of about 1,300 identical so-called CA proteins), a closed, stable container that protects the viral genetic material (see also June 2013 highlight Elusive HIV-1 Capsid and August 2015 highlight Anatomy of a Dormant Killer). Once in the cell ― while avoiding detection by cellular proteins ― the capsid deceives the cell and directs the cell machinery to transport it to the nucleus. The human-cell protein Cyclophilin A (CypA) is thereby exploited to act against the cells well being and to assist the HIV infection by getting the capsid to access the cell nucleus; this results in a delicate choreography accomplished by escaping anti-viral proteins in the cell and deceiving transport proteins at the nucleus, all of which contain a CypA domain that interacts directly with the capsid. Despite the availability of the crystal structure of the complex of CypA and CA proteins ...
http://www.ks.uiuc.edu/Highlights/?section=2015&highlight=2015-12
25th week of 2011 patent applcation highlights part 6425th week of 2011 patent applcation highlights part 64
NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such ...
http://www.patentsencyclopedia.com/hgl/06-23-11/06-23-11_64
Study Sheds Light on Aneurysm Prevention - HealthManagement.orgStudy Sheds Light on Aneurysm Prevention - HealthManagement.org
Researchers at the University of Rochester Medical Center in New York said removing the gene that makes the protein cyclophilin A protected mice genetica
https://healthmanagement.org/c/cardio/news/study-sheds-light-on-aneurysm-prevention
Regulation of HIV-1 Host Factor Interactions by Cyclophilin A - Mallori BurseRegulation of HIV-1 Host Factor Interactions by Cyclophilin A - Mallori Burse
The HIV-1 capsid is an important determinant of viral replication. Early studies demonstrated the intrinsic importance of the capsid in mediating uncoating of t...
http://grantome.com/grant/NIH/F31-AI108481-02
Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site - The Division of Structural Biology
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https://www.strubi.ox.ac.uk/publications/665126/
RCSB PDB - 6GJM: Cyclophilin A complexed with tri-vector ligand 4.RCSB PDB - 6GJM: Cyclophilin A complexed with tri-vector ligand 4.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/6GJM
Anti Human TRIM5 Alpha (N-Terminal) Antibody | Bio-RadAnti Human TRIM5 Alpha (N-Terminal) Antibody | Bio-Rad
|strong|Goat anti Human TRIM5 alpha antibody|/strong| recognizes an epitope within the N-terminal (NT) region of human TRIM5alpha, otherwise known as RNF88 (RING finger protein 88), a cytoplasmic pro…
https://www.bio-rad-antibodies.com/polyclonal/human-trim5-alpha-antibody-ahp1582.html
Anti-Cyclophilin 40 抗体 (ab3562) | アブカムAnti-Cyclophilin 40 抗体 (ab3562) | アブカム
ウサギ・ポリクローナル抗体 ab3562 交差種: Ms,Rat,Rb,Chk,Cow,Hu,NHuPrm 適用: WB,IP,IHC-P,IHC-Fr,ICC,Flow Cyt,ICC/IF…Cyclophilin…
http://www.abcam.co.jp/cyclophilin-40-antibody-ab3562.html
Modere Trim Reviews - What Does Modere Trim Do For You?Modere Trim Reviews - What Does Modere Trim Do For You?
Does Modere Trim help you lose weight? Read our Modere Trim review for ingredients, pros, cons, how it works, faq, price, and more!
https://www.consumerhealthdigest.com/weight-loss-reviews/modere-trim.html
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Cyclophilin | definition of cyclophilin by Medical dictionaryCyclophilin | definition of cyclophilin by Medical dictionary
Looking for online definition of cyclophilin in the Medical Dictionary? cyclophilin explanation free. What is cyclophilin? Meaning of cyclophilin medical term. What does cyclophilin mean?
https://medical-dictionary.thefreedictionary.com/cyclophilin
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?<...
TY - JOUR. T1 - Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?. AU - Sigal, N. H.. AU - Dumont, F.. AU - Durette, P.. AU - Siekierka, John. AU - Peterson, L.. AU - Rich, D. H.. AU - Dunlap, B. E.. AU - Staruch, M. J.. AU - Melino, M. R.. AU - Koprak, S. L.. AU - Williams, D.. AU - Witzel, B.. AU - Pisano, J. M.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In this report we have approached two questions relating to the mechanism of action of cyclosporin A (CsA). First, we address whether the major cytosolic protein for CsA, cyclophilin, is directly involved in mediating the immunosuppressive activity of this drug, and, in particular, whether inhibition of this proteins peptidyl-prolyl cis-trans isomerase (PPIase) activity results in inhibition of murine T cell activation. Second, we ask whether the nephrotoxicity observed with CsA is related to inhibition of PPIase-dependent pathways in cells other than lymphocytes. Using a series of 61 cyclosporin ...
https://researchwith.montclair.edu/en/publications/is-cyclophilin-involved-in-the-immunosuppressive-and-nephrotoxic-
Viruses | Free Full-Text | Cyclophilin Inhibitors as a Novel HCV Therapy | NotesViruses | Free Full-Text | Cyclophilin Inhibitors as a Novel HCV Therapy | Notes
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA probably interacts directly with nonstructural protein 5A to exert its effect, through its peptidyl-prolyl isomerase activity, on maintaining the proper structure and function of the HCV replicase. The major proline substrates are located in domain II of NS5A, centered around a
http://www.mdpi.com/1999-4915/2/8/1621/notes
Involvement of Cyclophilin D and Calcium in Isoflurane-induced PreconditioningInvolvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning
The mitochondrial permeability transition pore (PTP) has been established as an important mediator of ischemia-reperfusion-induced cell death. The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. Therefore, the authors hypothesized that isoflurane, by inhibiting the re...
https://insights.ovid.com/anesthesiology/anet/2015/12/000/involvement-cyclophilin-calcium-isoflurane-induced/28/00000542
Lirias: DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans...Lirias: DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans...
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of ...
https://lirias.kuleuven.be/handle/123456789/298525
Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with...Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with...
Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is over-expressed in prostate cancer and certain T-cell lymphomas. The groove for Hsp90 binding on the TPR domain includes residues Lys227 and Lys308, referred to as the carboxylate clamp, and is essential for Cyp40-Hsp90 binding. In this study, the effect of two mutations, K227A and K308A, and their combinative mutant was investigated by performing a total of 5.76 mu s of all-atom molecular dynamics (MD) simulations in explicit solvent. All simulations, except the K308A mutant, were found to adopt two distinct (extended or compact) conformers defined by different cyclophilin-TPR interdomain distances. The K308A mutant was only observed in the extended form which is observed in the Cyp40 X-ray structure. The wild-type, K227A, and ...
https://avesis.itu.edu.tr/yayin/a3888809-1839-4699-b231-e18beb5a8d8d/molecular-dynamics-simulations-of-site-point-mutations-in-the-tpr-domain-of-cyclophilin-40-identify-conformational-states-with-distinct-dynamic-and-enzymatic-properties
A Second-Generation Fungerp Analog, SCY-247, Shows Potent In Vitro Activity against Candida auris and Other Clinically Relevant...A Second-Generation Fungerp Analog, SCY-247, Shows Potent In Vitro Activity against Candida auris and Other Clinically Relevant...
Due to the increase of antifungal drug resistance and difficulties associated with drug administration, new antifungal agents for invasive fungal infections are needed. SCY-247 is a second-generation fungerp antifungal compound that interferes with the synthesis of the fungal cell wall polymer β-(1,3)-d-glucan. We conducted an extensive antifungal screen of SCY-247 against yeast and mold strains compared with the parent compound ibrexafungerp (IBX; formerly SCY-078) to evaluate the in vitro antifungal properties of SCY-247. SCY-247 demonstrated similar activity to IBX against all of the organisms tested. Moreover, SCY-247 showed a higher percentage of fungicidal activity against the panel of yeast and mold isolates than IBX. Notably, SCY-247 showed considerable antifungal properties against numerous strains of Candida auris. Additionally, SCY-247 retained its antifungal activity when evaluated in the presence of synthetic urine, indicating that SCY-247 maintains activity and structural ...
https://aac.asm.org/content/65/3/e01988-20
View all posts in Virology
1) Bosco, D.A., Eisenmesser, E.Z., Clarkson, M.W., Wolf-Watz, M., Labeikovsky, W., Millet, O., & Kern, D. (2010). Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the biological substrate HIV-capsid by NMR Journal of Molecular Biology DOI: 10.1016/j.jmb.2010.08.001. 2) Bosco, D.A., Eisenmesser, E.Z., Pochapsky, S., Sunquist, W.I., and Kern, D. (2002) Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proceedings of the National Academy of Sciences, 99(8), 5247-5252. DOI: 10.1073/pnas.082100499. 3) Braaten, D., & Luban, J. (2001). Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells The EMBO Journal, 20 (6), 1300-1309 DOI: 10.1093/emboj/20.6.1300 OPEN ACCESS. 4) Dorfman, T., Weimann, A., Borsetti, A., Walsh, C.T., & Göttlinger, H.G. (1997). Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions. Journal of Virology, 71 (9), ...
https://conflux.mwclarkson.com/category/biology/virology/
Most recent papers with the keyword cyclophilin | Read by QxMDMost recent papers with the keyword cyclophilin | Read by QxMD
To find and calibrate a robust and reliable computational protocol for mapping conformational space of medium-sized molecules, exhaustive conformational sampling has been carried out for the series of seven macrocyclic compounds of varying ring size and one acyclic analogue. While five of them were taken from the MD/LLMOD/force-field study by Shelley and coworkers (J. Chem. Inf. MODEL: 2014, 54, 2680), three represent potential macrocyclic inhibitors of human cyclophilin A. The free energy values (GDFT/COSMO-RS) for all conformers of each compound were obtained by the composite protocol based on the in vacuo quantum mechanics (DFT-D3 method in a large basis set), standard gas-phase thermodynamics and the COSMO-RS solvation model (QM+COSMO-RS ...
https://www.readbyqxmd.com/keyword/98444
Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the...Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the...
Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is
https://research.pasteur.fr/en/publication/characterization-of-the-anti-hepatitis-c-virus-activity-of-new-non-peptidic-small-molecule-cyclophilin-inhibitors-with-a-potential-for-broad-anti-activity/
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis - PubMedEvaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis - PubMed
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet …
https://pubmed.ncbi.nlm.nih.gov/31717385/
Structure Cluster - 3RCL: Human Cyclophilin D Complexed with a Fragment 3D Similarity Report PageStructure Cluster - 3RCL: Human Cyclophilin D Complexed with a Fragment 3D Similarity Report Page
3RCL: Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
https://www3.rcsb.org/pdb/explore/structureCluster.do?structureId=3RCL
Cyclophilin | ProSpecCyclophilin | ProSpec
ProSpecs Cyclophilins include: Cyclophilin-A Human Recombinant, Cyclophilin-B Human Recombinant, Cyclophilin-D Human Recombinant
https://www.prospecbio.com/cyclophilin
anti-PPIL1 antibody [N1C3] | GeneTexanti-PPIL1 antibody [N1C3] | GeneTex
PPIL1 antibody [N1C3] (peptidylprolyl isomerase (cyclophilin)-like 1) for ICC/IF, WB. Anti-PPIL1 pAb (GTX118126) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/PPIL1-antibody-N1C3-GTX118126.html
5ta4.1 | SWISS-MODEL Template Library
SWISS-MODEL Template Library (SMTL) entry for 5ta4.1. Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A
https://swissmodel.expasy.org/templates/5ta4.1
Synthesis and in vitro evaluation of new nonpeptidic inhibitors of the peptidyl-prolyl-isomerase Pin1 - Research CollectionSynthesis and in vitro evaluation of new nonpeptidic inhibitors of the peptidyl-prolyl-isomerase Pin1 - Research Collection
ARZNEIMITTELENTWICKLUNG + ARZNEIMITTELDESIGN + ARZNEIMITTELENTDECKUNG; ORGANISCHE SYNTHESE (CHEMIE); PEPTIDYLPROLYL-ISOMERASE, CYCLOPHILIN (ENZYME); ENZYMINHIBITOREN (BIOCHEMIE); DRUG DEVELOPMENT + DRUG DESIGN + DRUG DISCOVERY (PHARMACY); ORGANIC SYNTHESIS (CHEMISTRY); PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN (ENZYMES); ENZYME INHIBITORS (BIOCHEMISTRY ...
https://www.research-collection.ethz.ch/handle/20.500.11850/149092
Cyclophilin D Enzyme Human Recombinant | CypD Protein | ProSpecCyclophilin D Enzyme Human Recombinant | CypD Protein | ProSpec
Cyclophilin-D Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 178 aa having a molecular mass of 18.9kDa.
https://www.prospecbio.com/human_cyclophilin_d
ppia Expression [Xenopus] - Xenbase Gene Catalogppia Expression [Xenopus] - Xenbase Gene Catalog
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari. ...
http://www.xenbase.org/gene/expression.do?method=displayGenePageExpression&geneId=5777999&tabId=1
Professor Greg Towers Research GroupProfessor Greg Towers Research Group
Keywords: HIV; Herpes; Host Factors; Host-Pathogen Interactions; Innate Immunity; Infection; Viruses; Restriction; Cyclophilin; TRIM5; Tetherin; Tropism; Gene ...
http://www.ucl.ac.uk/infection-immunity/research/tabs/towers_short
TRIM7ELISA试剂盒产品概述TRIM7ELISA试剂盒产品概述
多种适用的TRIM7ELISA试剂盒，如等。在antibodies-online.cn对比TRIM7ELISA试剂盒，以便找到您需要的产品。
http://www.antibodies-online.cn/abstract/Tripartite+Motif+Containing+7+
1-(4-hydroxy-3-methoxyphenyl)propan-1-one 1835-14-9 H-NMR | C-NMR Spectral Analysis NMR Spectrum1-(4-hydroxy-3-methoxyphenyl)propan-1-one 1835-14-9 H-NMR | C-NMR Spectral Analysis NMR Spectrum
1-(4-hydroxy-3-methoxyphenyl)propan-1-one 1835-14-9 NMR spectrum, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one H-NMR spectral analysis, 1-(4-hydroxy-3-methoxyphenyl)propan-1-one C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_1835-14-9-moldata-36290.html
PLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl IsomerasesPLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
http://journals.plos.org/plosbiology/article/comments?id=10.1371/journal.pbio.1000439&imageURI=info:doi/10.1371/journal.pbio.1000439.g004
PLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl IsomerasesPLOS Biology: Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
Author Summary Cyclophilins are proteins that catalyze the isomerization of prolines, interconverting this structurally important amino acid between cis and trans isomers. Although there are 17 cyclophilins in the human genome, the function of most cyclophilin isoforms is unknown. At least some members of this protein family are of interest for clinically relevant drug design, as they are targets of the drug cyclosporin, which is used as an immunosuppressant to treat patients following organ transplantation. The absence of a comprehensive picture of the similarities and differences between the different members of this protein family precludes effective and specific drug design, however. In the current study we undertake such a global structure∶function analysis. Using biochemical, structural, and computational methods we characterize the human cyclophilin family in detail and suggest that there is a previously overlooked region of these enzymes that contributes significantly to isoform diversity. We
http://journals.plos.org/plosbiology/article/authors?id=10.1371/journal.pbio.1000439&imageURI=info:doi/10.1371/journal.pbio.1000439.g006
Viruses | Free Full-Text | Insights into the Roles of Cyclophilin A During Influenza Virus InfectionViruses | Free Full-Text | Insights into the Roles of Cyclophilin A During Influenza Virus Infection
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
http://mdpi.com/1999-4915/5/1/182
Molecular characterization of cyclophilin A-like protein from Piriformospora indica for its potential role to abiotic stress...Molecular characterization of cyclophilin A-like protein from Piriformospora indica for its potential role to abiotic stress...
Cyclophilins (CyP), conserved in all genera, are known to have regulatory responses of various cellular processes including stress tolerance. Interestingly, CyP has a crucial role as peptidyl-prolyl cis-trans isomerases (PPIases). Our earlier in silico based approach resulted into the identification of cyclophilin family from rice, Arabidopsis and yeast. In our recent report, we discovered a new OsCYP-25 from rice. Here, we identified a novel cyclophylin A-like protein (PiCyP) from Piriformospora indica which is responsible for abiotic stress tolerance in E. coli. Cyclophylin A-like protein (CyPA) (accession number GQ214003) was selected from cDNA library. The genomic organization CyPA revealed a 1304 bp of CyPA in P. indica genome, showing 10 exons and 9 introns. Further, CyPA was evident in PCR with gDNA and cDNA and Southern blot analysis. The phylogenetic examination of CyPA of P. indica showed that it is closed to human cyclophilin. The uniqueness of PiCyPA protein was apparent in western blot
https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-6-555
Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention<...
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
https://mayoclinic.pure.elsevier.com/en/publications/novel-approach-to-inhibit-asthma-mediated-lung-inflammation-using
Rat CYPB(Cyclophilin B) ELISA Kit - Rat CYPB(Cyclophilin B) ELISA Kit Exporter, Importer, Manufacturer, Distributor, Supplier,...
SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Rat CYPB(Cyclophilin B) ELISA Kit based in Delhi, India
https://www.srgroupchemical.com/rat-cypb-cyclophilin-b-elisa-kit-4473194.html
Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin<...
TY - JOUR. T1 - Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin. AU - Cirillo, Raffaele. AU - Triggiani, Massimo. AU - Siri, Lorenzo. AU - Ciccarelli, Anna. AU - Pettit, George. AU - Condorelli, Mario. AU - Marone, Gianni. PY - 1990. Y1 - 1990. N2 - We have examined the effects of cyclosporin A (CsA) and a series of CsA analogs that bind with decreasing affinity to cyclophilin, to evaluate the involvement of this protein in the release of preformed (histamine) and de novo synthesized (peptide leukotriene C4; LTC4) mediators of inflammatory reactions from human basophils. CsA (8 to 800 nM) concentration-dependently inhibited (5 to 60%) histamine release from peripheral blood basophils challenged with anti-IgE. CsA was more potent (92.6 ± 1.8 vs 59.1 ± 4.5%; p , 0.001) and, at low concentrations, more effective when the channel-operated influx of Ca2+ as bypassed by the ionophore A23187 (IC40 = 24.1 ± 3.9 vs 105.5 ± 22.2 nM; p , ...
https://asu.pure.elsevier.com/en/publications/cyclosporin-a-rapidly-inhibits-mediator-release-from-human-basoph
Anti Cyclophilin A Antibody (PrecisionAb™ Polyclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)Anti Cyclophilin A Antibody (PrecisionAb™ Polyclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)
Cyclophilin antibody for detecting human peptidyl-prolyl cis-trans isomerase A. Validated on up to 12 cell lysates for western blotting. Try a trial size today.
https://www.bio-rad-antibodies.com/human-cyclophilin-a-antibody-vpa00548.html
Yellow Lupine Cyclophilin Transcripts Are Highly Accumulated in the Nodule Meristem ZoneYellow Lupine Cyclophilin Transcripts Are Highly Accumulated in the Nodule Meristem Zone
Molecular Plant-Microbe Interactions 14:1384-1394...Katarzyna Nuc , 1 Przemysław Nuc , 1 , 2 and Ryszard Słomski 1...© 2001 The American Phytopathological Society...Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an intronless gene coding for cytosolic CyP have been isolated from yellow lupine. The deduced amino acid sequence of the characterized open reading frame shows approximately 80% homol...
https://www.apsnet.org/publications/mpmi/2001/December/Pages/14_12_1384.aspx
Cyclophilin B - bs-6609R | acris-antibodies.com
Cyclophilin B, 0.1 ml. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
https://www.acris-antibodies.com/antibodies/primary-antibodies/cyclophilin-b-bs-6609r.htm
siGENOME Cyclophilin B Control siRNA | Dharmacon
A validated positive silencing control targeting the Cyclophilin B (PPIB) gene in human, mouse, or rat cell lines. Useful for determination of optimal RNAi experimental conditions
http://dharmacon.gelifesciences.com/rnai/controls/sirna/sigenome/sigenome-cyclophilin-b-control-sirna/
Post-translational modificationsPost-translational modifications
Figure 3. Genetically encoded N-epsilon lysine acetylation allows the high resolution X-ray structures of acetylated proteins and their complexes to be solved. The high resolution structure of acetyl lysine from acetylated cyclophilin (left) showing the experimental density. Right, Acetylated cyclophilin in complex with cyclosporine. Water molecules (blue spheres) that are ordered at the protein small molecule interface in the unacetylated complex) rearrange in the acetylated complex.. The acetylation of a cyclophilin at Lys125 was identified in a proteomics screen. We subsequently demonstrated that a substantial proportion of CYPA is acetylated in HeLa cells and human T cell lines, suggesting that the acetylated form of the protein is biologically relevant. To test this, recombinant CYPA bearing homogenous acetylation at Lys125 was prepared by overexpression in E. coli using an acetyllysyl-tRNA synthetase-tRNACUA pair, allowing detailed biophysical and enzymatic characterization of acetylated ...
http://www2.mrc-lmb.cam.ac.uk/ccsb/?page_id=46
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP AntibodyAnti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_A-K/CyCAP?sitex=10020:22372:US&PEBCL1=XycBPS5ep01D5HH439enKFKVt4&PEBCL1_pses=ZG278E2D79FD678EB2D804BB908D210D3123EBB45E18C2294CEDB12ED10DBAA4BDB1C8BBE730EDBF31523584EF681CEF3707077E50534BDEC8
Anti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP AntibodyAnti-Rat CyCAP Antibody | Rat CyCAP Antibody | CyCAP Antibody
Cyclophilin C-associated protein (CyCAP) has been proposed as the endogenous equivalent of the immunosuppressant drug, cyclosporin A. It competes with cyclosporin A for binding to cyclophilin C. It is also known as lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp); Cyp-C-associated protein, 90K, Ppicap, and MAC-2BP. CyCAP expression has been reported in brain, kidney, macrophage cells, dermal fibroblasts, and keratinocytes. Roles for CyCAP have been reported in wound healing and macrophage activation via association with nuclear factor of activated T-cells (NFAT).. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Miscellaneous/Primary_Antibodies_A-K/CyCAP?sitex=10020:22372:US&PEBCL1=VKO798Kv69kykYjwpMZykmIsiK&PEBCL1_pses=ZGDAC7694A7FC1421AFDADF1AABE5E4D675AF996C1910AA034213EEAFB56436BE9526E61AF77E02EDFF748384C2263A714847716176665CFF4
Accell siRNAAccell siRNA
Mast cells were purified from human skin of healthy donors according to our routine protocol (e.g. PMID: 14634065, 15191551, 15666093, 15675967, 20545757, 24671954, 25725371, 26706922, 28264498, 28845295, 28859248), reaching 98-100% purity, and transfected with siRNA as specified by the Dharmacon; all siRNAs were used at 1 µM. (A) Cellular uptake of siRNA, as measured by fluorescence microscopy using PE-labeled (non-targeting) siRNA (24 h after transfection). (B) and (C) relative gene expression in cells transfected with non-targeting siRNA versus siRNA targeting either GAPDH or Cyclophilin B, measured by RT-qPCR (48 h post-transfection) and normalized to control expression given as 1. Mean ± SEM of n = 6-9 individual experiments. Note that the knockdown was both highly efficient and specific, as only the targeted RNA was downregulated, while the Cyclophilin B-specific siRNA had no impact on GAPDH expression and vice versa. ** p , 0.01; *** p , 0.01; ****p , 0.0001 by Kruskal-Wallis test with ...
https://horizondiscovery.com/en/products/gene-modulation/knockdown-reagents/sirna/accell-sirna
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There becomes a better download soil mechanics to encode your situation cyclophilin. With term, the image you think Is you to keep up a broad dating chip for the structures and clouds that you represent to chop in your web on this problem. fighter thinking to make the Measure that you most rendezvous forward from across this bank into one 6-fold team, bulging you greater article over how you have with your NVA.
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Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the...Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the...
Fingerprint Dive into the research topics of Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain. Together they form a unique fingerprint. ...
https://scholars.uthscsa.edu/en/publications/recognition-of-the-hiv-capsid-by-the-trim5%CE%B1-restriction-factor-is/fingerprints/
Elegant Trim Return Address by 123PrintElegant Trim Return Address by 123Print
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CyclophilinCyclophilin
Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a calcium/ ... Cyclophilin A is a cytosolic and highly abundant protein. The protein belongs to a family of isozymes, including cyclophilins B ... Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is ... Cyclophilin inhibitors, such as cyclosporin, are being developed to treat neurodegenerative diseases. Cyclophilin inhibition ...
https://en.wikipedia.org/wiki/Cyclophilin
PRPF3PRPF3
Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a ... Horowitz DS, Lee EJ, Mabon SA, Misteli T (Feb 2002). "A cyclophilin functions in pre-mRNA splicing". The EMBO Journal. 21 (3): ... a nuclear cyclophilin" (PDF). The Journal of Biological Chemistry. 275 (11): 7439-42. doi:10.1074/jbc.275.11.7439. PMID ... "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". Journal of Molecular ...
https://en.wikipedia.org/wiki/PRPF3
RANBP2RANBP2
Ferreira PA, Nakayama TA, Pak WL, Travis GH (Oct 1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green ... Ferreira PA, Yunfei C, Schick D, Roepman R (Sep 1998). "The cyclophilin-like domain mediates the association of Ran-binding ... Yi H, Friedman JL, Ferreira PA (Nov 2007). "The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the ... Ferreira PA, Hom JT, Pak WL (Sep 1995). "Retina-specifically expressed novel subtypes of bovine cyclophilin". The Journal of ...
https://en.wikipedia.org/wiki/RANBP2
PPIL2PPIL2
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ... 2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866-71. doi: ... "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2". Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). " ... 2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. ...
https://en.wikipedia.org/wiki/PPIL2
PPIL3PPIL3
This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide ... Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the ... "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high ... cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3-4): 231-6. doi:10.1159/000056909 ...
https://en.wikipedia.org/wiki/PPIL3
PPIL1PPIL1
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved ... "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical ... expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. ...
https://en.wikipedia.org/wiki/PPIL1
Cis-trans isomeraseCis-trans isomerase
Examples include photoisomerase and immunophilins such as cyclophilin. cis-trans-Isomerases at the US National Library of ...
https://en.wikipedia.org/wiki/Cis-trans_isomerase
PPIFPPIF
As a cyclophilin, PPIF binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Like other cyclophilins, PPIF forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a ...
https://en.wikipedia.org/wiki/PPIF
PPIL4PPIL4
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, ... "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4". Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, ... structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell ...
https://en.wikipedia.org/wiki/PPIL4
AlisporivirAlisporivir
It inhibits cyclophilin A. Alisporivir is not immunosuppressive. It is being researched for potential use in the treatment of ... Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of, and ... April 2008). "Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin ... December 2008). "Debio 025, a cyclophilin binding molecule, is highly efficient in clearing HCV replicon containing cells, ...
https://en.wikipedia.org/wiki/Alisporivir
Peptidylprolyl isomerase APeptidylprolyl isomerase A
Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ... Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by ... Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in ...
https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase_A
PPIBPPIB
As a cyclophilin, PPIB binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene ... Mikol V, Kallen J, Walkinshaw MD (1994). "X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A ... As a cyclophilin, PPIB binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. PPIB is the ...
https://en.wikipedia.org/wiki/PPIB
PPICPPIC
As a cyclophilin, PPIC binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Depletion of these two cyclophilins lead to hyperoxidation of the ER. In the brain, PPIC complexes with cyclophilin C- ... Like other cyclophilins, PPIC forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ... Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C (Mar 2005). "Roles of cyclophilins in cancers and other organ systems". World ...
https://en.wikipedia.org/wiki/PPIC
Peptidylprolyl isomerase DPeptidylprolyl isomerase D
As a cyclophilin, PPID binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets calcineurin ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on ... Like other cyclophilins, PPID forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti- ...
https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase_D
PPIE (gene)PPIE (gene)
As a cyclophilin, PPIE also binds the immunosuppressive drug CsA to form a CsA-cyclophilin complex, which then targets ... Thus, cyclophilins may function in cardioprotection during ischemia-reperfusion injury. Currently, cyclophilin expression is ... Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on ... Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, Sun L, Gao GF, Ye X, Liu W (2011). "Cyclophilin E functions as a negative ...
https://en.wikipedia.org/wiki/PPIE_(gene)
CLK1CLK1
Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin ...
https://en.wikipedia.org/wiki/CLK1
FKBPFKBP
... which binds cyclophilin. Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called ... Along with cyclophilin, FKBPs belong to the immunophilin family. FKBP12 is notable in humans for binding the immunosuppressant ... FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins ... Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin- ...
https://en.wikipedia.org/wiki/FKBP
PPIG (gene)PPIG (gene)
Lin CL, Leu S, Lu MC, Ouyang P (2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR ... Nestel FP, Colwill K, Harper S, Pawson T, Anderson SK (Jan 1997). "RS cyclophilins: identification of an NK-TR1-related ... "Entrez Gene: PPIG peptidylprolyl isomerase G (cyclophilin G)". Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (Aug 2004). " ... 2004). "The human nuclear SRcyp is a cell cycle-regulated cyclophilin". J. Biol. Chem. 279 (21): 22322-30. doi:10.1074/jbc. ...
https://en.wikipedia.org/wiki/PPIG_(gene)
Calcium modulating ligandCalcium modulating ligand
When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein ... Bram RJ, Crabtree GR (1994). "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein". Nature. 371 (6495 ... Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ (2000). "Calcium-modulating cyclophilin ligand desensitizes hormone-evoked ... Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of ...
https://en.wikipedia.org/wiki/Calcium_modulating_ligand
Methods used to study memoryMethods used to study memory
The Role of Cyclophilin D in learning and memory. Brush, F. Robert (2003). "Selection for Differences in avoidance Learning: ...
https://en.wikipedia.org/wiki/Methods_used_to_study_memory
Ischemia-reperfusion injury of the appendicular musculoskeletal systemIschemia-reperfusion injury of the appendicular musculoskeletal system
To the end of this, necrosis occurs by physical interaction with the PTP regulator cyclophilin D (CypD). The mitochondrial p53- ... Alam, M.R.; D. Baetz; M. Ovize (2015). "Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective". J Mol ...
https://en.wikipedia.org/wiki/Ischemia-reperfusion_injury_of_the_appendicular_musculoskeletal_system
CiclosporinCiclosporin
Cyclosporin A binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, ... It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases ... This cyclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of ... Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding ...
https://en.wikipedia.org/wiki/Ciclosporin
Hypothermia therapy for neonatal encephalopathyHypothermia therapy for neonatal encephalopathy
February 2009). "Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury". The Journal of ...
https://en.wikipedia.org/wiki/Hypothermia_therapy_for_neonatal_encephalopathy
Bump and holeBump and hole
... cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair was ... The bumped cyclosporin A was found to interact efficiently with the hole-modified cyclophilin mutant, but not endogenous ... cyclophilin. The orthogonal CID pair was used to inhibit calcineurin-mediated dephosphorylation of nuclear factor of activated ... engineered to improve the binding efficiency between wild type cyclosporin A and cyclophilin, thereby giving more efficient CID ...
https://en.wikipedia.org/wiki/Bump_and_hole
OPN1MWOPN1MW
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
https://en.wikipedia.org/wiki/OPN1MW
List of examples of convergent evolutionList of examples of convergent evolution
Examples comprise fibronectin/long chain cytokines, NEF/SH2, cyclophilin/capsid proteins. The most well-studied example is the ...
https://en.wikipedia.org/wiki/List_of_examples_of_convergent_evolution
Hereditary equine regional dermal astheniaHereditary equine regional dermal asthenia
2009). "Methods for detecting a cyclophilin B SNP associated with HERDA". Retrieved September 2, 2016. Horsetalk.co.nz: HERDA a ... "Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the ...
https://en.wikipedia.org/wiki/Hereditary_equine_regional_dermal_asthenia
OPN1LWOPN1LW
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin ...
https://en.wikipedia.org/wiki/OPN1LW
BasiginBasigin
... is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... June 2002). "Active site residues of cyclophilin A are crucial for its signaling activity via CD147". The Journal of Biological ... Yurchenko V, Constant S, Bukrinsky M (March 2006). "Dealing with the family: CD147 interactions with cyclophilins". Immunology ...
https://en.wikipedia.org/wiki/Basigin
FKBP1AFKBP1A
Yang WM, Inouye CJ, Seto E (Jun 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The ... a peptidylprolyl cis-trans isomerase distinct from cyclophilin". Proceedings of the National Academy of Sciences of the United ...
https://en.wikipedia.org/wiki/FKBP1A
JCI - Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injuryJCI - Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. ... Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and ... Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular ...
https://www.jci.org/articles/view/133082/ga
Functional association of cyclophilin A with HIV-1 virions | Semantic ScholarFunctional association of cyclophilin A with HIV-1 virions | Semantic Scholar
CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase ... Drug-induced reductions in virion-associated cyclophilin A levels were accompanied by reductions in virion infectivity, ... The association of cyclophilin A with HIV-1 virions was inhibited in a dose-dependent manner by cyclosporin A as well as by SDZ ... contain significant amounts of cyclophilin A. Sequences in the capsid domain of p55gag are both required and sufficient for the ...
https://www.semanticscholar.org/paper/Functional-association-of-cyclophilin-A-with-HIV-1-Thali-Bukovsky/c13ea026f5aa710c1e374e226e189096319b54df
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCOCyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium - JASCO
Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. By Shivam Yadav, Martin ... Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. Most of them ... Here, we show that cyclophilin anaCyp40 from the cyanobacterium Anabaena sp. PCC 7120 is enzymatically active, and seems to be ... The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and ...
https://jascoinc.com/knowledgebase/cyclophilin-anacyp40-regulates-photosystem-assembly-and-phycobilisome-association-in-a-cyanobacterium/
RCSB PDB - 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.RCSB PDB - 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.
Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. ... Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A.. *PDB DOI: ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ... Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex ...
https://www.rcsb.org/structure/2WFJ
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70<...
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. A. Carrello, Rudi Allan, Sarah Morgan, B.A.L. Owen, D. Mok, B.K ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. / Carrello, A.; Allan, Rudi; Morgan, Sarah et al. ... Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. In: Cell Stress & Chaperones. 2004 ; Vol. 9. pp. 167-181. ... Dive into the research topics of Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Together they form a unique ...
https://research-repository.uwa.edu.au/en/publications/interaction-of-the-hsp90-cochaperone-cyclophilin-40-with-hsc70
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic...Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic...
Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ... We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB ... Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic ...
https://scholars.duke.edu/display/pub800971
Cyclophilin D deficiency prevents diet-induced obesity in mice - Fingerprint - Research Nebraska
Cyclophilin D deficiency prevents diet-induced obesity in mice. Kishor Devalaraja-Narashimha, Alicia M. Diener, Babu J. ... Dive into the research topics of Cyclophilin D deficiency prevents diet-induced obesity in mice. Together they form a unique ...
https://experts.nebraska.edu/en/publications/cyclophilin-d-deficiency-prevents-diet-induced-obesity-in-mice/fingerprints/
Rat CYPA (Cyclophilin A) ELISA Kit - BidScientific.com
Rat CYPA (Cyclophilin A) ELISA Kit. E-EL-R0298 Regular price $580.00. $499.00 You Pay ...
https://www.bidscientific.com/products/e-el-r0298
S-EPMC145517 - Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. - OmicsDI
Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 ... cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gags interaction with cyclophilins ... indicating that no other cyclophilin family members promote HIV-1 replication. The defective replication phenotype was specific ... Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. ...
https://www.omicsdi.org/dataset/biostudies/S-EPMC145517
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach<...Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach<...
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. / Ni, Shuaishuai; Yuan, Yaxia ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. In: Journal of Medicinal ... Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. Journal of Medicinal ... Dive into the research topics of Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design ...
https://scholars.uthscsa.edu/en/publications/discovering-potent-small-molecule-inhibitors-of-cyclophilin-a-usi
Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial...Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial...
... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D, Neuroscience, vol. 155, no. 3, pp. 585-596 ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. In: Neuroscience. 2008 ; Vol. 155, No. 3. pp ... encoding mitochondrial cyclophilin D (CyPD). Mitochondrial CyPD is a key modulator of the mitochondrial permeability transition ... and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. Neuroscience. 2008 Aug 26;155(3):585-596. ...
https://ohsu.pure.elsevier.com/en/publications/enhancement-of-anxiety-facilitation-of-avoidance-behavior-and-occ-2
Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with antifungal...Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with antifungal...
Of which, 65 GhCYPs only contained one cyclophilin type PPIase domain, others 14 GhCYPs contain additional domains. A number of ... Cyclophilins (CYPs), belonging to the peptidyl prolyl cis/trans isomerase (PPIase) superfamily, play important roles during ... From: Genome-wide identification of cyclophilin genes in Gossypium hirsutum and functional characterization of a CYP with ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-019-1848-1/figures/3
Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires | BMC Genomics | Full...
Twelve of the 17 human cyclophilins and both human parvulins, but only one of the 13 human FKBPs, identified orthologues within ... whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more ... multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle ... whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. A comparison of their known functions ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-7-244
Cerebrovascular Insulin Receptors Are Defective in ADCerebrovascular Insulin Receptors Are Defective in AD
Cyclophilin B; EC = Extracellular; IC = Intracellular; O.D. = optical density; P = Microvessel-depleted parenchymal fraction; T ... Cyclophilin B; EC = Extracellular; IC = Intracellular; O.D. = optical density; P = Microvessel-depleted parenchymal fraction; T ...
https://www.medscape.com/viewarticle/986914_2
IMSEAR at SEARO: A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli.
By using this method, highly purified GST-cyclophilin A (CypA) fusion protein was obtained, without affecting the structural ... A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. ... A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. Indian Journal of Biochemistry ...
https://imsear.searo.who.int/handle/123456789/27413
Letters To The EditorLetters To The Editor
Cyclophilin B (CypB) was first described and its sequence was reported by Spik et al. in 1991 (1). These authors prepared and ... Cyclophilin B is really a major growth factor in breast milk. Journal of Biological Chemistry ...
https://www.jbc.org/letters-to-the-editor?startPage=&Ppub=%5B20201125%20TO%2020221125%5D
Cloning and Expression Analysis of Cyclophilins A(<em>CyPA</em>) Gene...
Cyclophilins (CyPs) are widely distributed in organisms, and play impo... ... Abstract: Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. Cyclophilin A-like was screened in ... Cloning and Expression Analysis of Cyclophilins A(CyPA) Gene form Chlorella WANG Xu-Hui;QIAO Kun;WANG Zhen-Juan;GUAN Qing-Jie*; ... So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in ...
http://bbr.nefu.edu.cn/EN/10.7525/j.issn.1673-5102.2014.02.017
Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through...Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through...
Studies showed cyclophilin A (CypA) playing an important role in regulating MMP-9 expression in varied diseases. The aim of the ... gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through cyclophilin A.. ...
https://pesquisa.bvsalud.org/odontologia/resource/pt/mdl-33999413
2igv.1 | SWISS-MODEL Template Library
CYCLOPHILIN 3 Complexed with DIPEPTIDE SER-PRO Coordinates. PDB Format Method. X-RAY DIFFRACTION 1.67 Å. Oligo State. monomer. ...
https://swissmodel.expasy.org/templates/2igv.1
Hypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews NephrologyHypertension-induced cognitive impairment: from pathophysiology to public health | Nature Reviews Nephrology
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimers mice via cyclophilin A ...
https://www.nature.com/articles/s41581-021-00430-6?error=cookies_not_supported&code=3272588f-a6a7-4334-86f0-aea320dff92d
Crosstalk between cyclophilins and T lymphocytes in coronary artery disease | Documentos - Universidade de Santiago de...
Crosstalk between cyclophilins and T lymphocytes in coronary artery disease * Gegunde, S. 12 ...
https://investigacion.usc.gal/documentos/604c18ff96a5c520fe407eea
PPIAP74 peptidylprolyl isomerase A pseudogene 74 [Homo sapiens (human)] - Gene - NCBIPPIAP74 peptidylprolyl isomerase A pseudogene 74 [Homo sapiens (human)] - Gene - NCBI
peptidylprolyl isomerase A (cyclophilin A) pseudogene. NCBI Reference Sequences (RefSeq) Go to the top of the page Help ...
https://www.ncbi.nlm.nih.gov/gene/131055
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to...
Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ... Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to ...
https://www.ibb.cnr.it/?command=search&table=bibliography&idb=54798
Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas...Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas...
Membrane localization of a Myb3 transcription factor regulated by a Tv CyP1 cyclophilin in the parasitic protozoan Trichomonas ...
https://ir.sinica.edu.tw/handle/201000000A/72334
Fischkoff SA[au] - Search Results - PubMedFischkoff SA[au] - Search Results - PubMed
Leukocyte chemotactic activity of cyclophilin. Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR. Xu Q, et al. Among ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Fischkoff+SA%5Bau%5D&dispmax=50
DeCS - Termos NovosDeCS - Termos Novos
CYCLOPHILINS. CICLOFILINAS. CICLOSPORÍASE. CYCLOSPORIASIS. CICLOSPORIASIS. CIRCULAÇÃO PLACENTÁRIA. PLACENTAL CIRCULATION. ...
https://decs.bvs.br/P/news2001pie.htm
Potential adverse effects of nanoparticles on the reproductive system | IJNPotential adverse effects of nanoparticles on the reproductive system | IJN
... cyclophilin periplasmic; CdTe, cadmium telluride; COOH, carboxylate; DSP, daily sperm production; E2, estradiol; FLGO, few- ...
https://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-fulltext-article-IJN
TCDB » SEARCHTCDB » SEARCH
Cyclophilin B is an accessory activating protein (Stumpf et al., 2008). The crystal structure of rat TRPV6 at 3.25 A resolution ...
https://tcdb.org/search/result.php?tc=1.A.4.2.11
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... cyclophilin forward, 5′-AGG TCC TGG CAT CTT GTC CAT-3′, cyclophilin reverse, 5′-GAA CCG TTT GTG TTT GGT CCA-3′ (amplicon length ... C, Detection of RAGE and cyclophilin mRNA in blood by real-time RT-PCR confirmed the efficiency of bone-marrow transplantation ... 51 bp). Quantified results of RAGE cDNA were normalized to cyclophilin. The purity of the amplified products was checked by the ...
https://www.jneurosci.org/content/28/46/12023
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View Rabbit Polyclonal anti-RPL13A Antibody (NBP1-32710). Validated Applications: WB, ICC/IF, IHC, IHC-P. Validated Species: Human, Mouse, Rat + more.
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CyPAMitochondrialProteinActivity of cyclophilinInhibitorsImmunophilinsPPIaseCyclosporinGeneSmall moleculeCyPsCypBRecombinantInteractsProlylArabidopsisMiceReplicationFunctionalSurvivalCellsDomainCellRoleStudy
CyPA8
  • Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation because it was detected in HIV-1 virions. (omicsdi.org)
  • Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis-trans isomerases (PPIases), which can bind to cyclosporin A (CsA). (omicsdi.org)
  • This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3). (uthscsa.edu)
  • By using this method, highly purified GST-cyclophilin A (CypA) fusion protein was obtained, without affecting the structural and functional characteristics such as PPIase and chaperone activities. (who.int)
  • Studies showed cyclophilin A (CypA) playing an important role in regulating MMP -9 expression in varied diseases . (bvsalud.org)
  • So we speculated that CyPA genes were associated with abiotic stress resistance, through the cyclophilin A involved in improving survival ability of resistant organisms. (nefu.edu.cn)
  • Cloning and Expression Analysis of Cyclophilins A( CyPA ) Gene form Chlorella[J]. Bulletin of Botanical Research, 2014, 34(2): 245-251. (nefu.edu.cn)
  • Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. (cnr.it)
Mitochondrial6
  • In neonatal mice and cultured differentiating oligodendrocytes, sublethal intermittent hypoxic (IH) stress activated cyclophilin D-dependent mitochondrial proton leak and uncoupled mitochondrial respiration, leading to transient bioenergetic stress. (jci.org)
  • Our study identified the cyclophilin D-dependent mitochondrial proton leak and uncoupling as a potentially novel subcellular mechanism for the maturational failure of oligodendrocytes and offers a potential therapeutic target for prevention of diffuse WMI in premature infants experiencing chronic IH stress. (jci.org)
  • In this report, we have assessed the behavioral responses of mice missing the Ppif gene (CyPD-KO), encoding mitochondrial cyclophilin D (CyPD). (elsevier.com)
  • Dive into the research topics of 'Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D'. Together they form a unique fingerprint. (elsevier.com)
  • The non-immunosuppressive cyclophilin inhibitor NIM811 prevented mitochondrial depolarization in response to oligomycin in melanocytes from both Ullrich congenital muscular dystrophy and Bethlem myopathy patients, and partially restored the respiratory reserve of melanocytes from one Bethlem myopathy patient. (elsevier.com)
  • Several NSAIDs indeed trigger increases in mobile [Ca2+] and oxidant tension (Tanaka research with cultured enterocytes, where high concentrations of diclofenac could actually trigger cyclosporin ACsensitive adjustments in calcein/Co2+ fluorescence, a recognized indicator from the mPT (LoGuidice by focusing on cyclophilin D (CypD), a mitochondrial matrix proteins and important regulator from the mPT. (cancerhugs.com)
Protein7
  • Cyclophilin A acts as protein folding chaperones and intracellular transports in many cellular processes. (omicsdi.org)
  • Previous studies have shown that cyclophilin A can interact with HIV-1 (human immunodeficiency virus type 1) gag protein and enhance viral infectivity. (omicsdi.org)
  • A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)
  • The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)
  • IMSEAR at SEARO: A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli. (who.int)
  • Cyclophilin B is an accessory activating protein ( Stumpf et al . (tcdb.org)
  • Each sample was analyzed for the expression of two candidate genes, aromatase (CYP19) and peroxisome proliferator activated receptor protein gamma (PPARgamma) and three potential internal controls: cyclophilin (CYC), 18S rRNA (18S), and total RNA. (cdc.gov)
Activity of cyclophilin2
  • Following a computer-aided virtual screening and subsequent surface plasmon resonance (SPR) analysis, 12 low molecular weight cyclophilin A ligands were selected for further evaluation of their in vitro inhibition of peptidyl-prolyl cis-trans isomerase (PPIase) activity of cyclophilin A and HIV-1 replication. (omicsdi.org)
  • Leukocyte chemotactic activity of cyclophilin. (nih.gov)
Inhibitors4
  • Many cyclophilin A inhibitors such as cyclosporin A can inhibit HIV-1 replication in vitro. (omicsdi.org)
  • Here, we report a structure-based identification of novel non-peptidic cyclophilin A inhibitors as anti-HIV lead compounds. (omicsdi.org)
  • Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. (omicsdi.org)
  • Certain drugs of the cyclosporine family, such as cyclosporin A (CsA), are reversible inhibitors of mPT via direct interaction with cyclophilin D, which is a known part of the pore forming complex. (lu.se)
Immunophilins2
  • Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. (jascoinc.com)
  • Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. (usc.es)
PPIase2
  • 2WFJ: Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. (rcsb.org)
  • Given this data, we would hypothesize that: (i) the evolution of the fungal PPIases is driven, at least in part, by the size of the proteome, (ii) evolutionary pressures differ both between the different PPIase families and the different fungi, and (iii) whilst the cyclophilins and parvulins have evolved to perform conserved functions, the FKBPs have evolved to perform more variable roles. (biomedcentral.com)
Cyclosporin4
  • CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl prolylcis trans isomerase activity, and assist in the folding of proteins1 6. (semanticscholar.org)
  • Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. (semanticscholar.org)
  • HIV-1 replication in PPIA(-/-) cells was decreased and not inhibited further by cyclosporin or gag mutations that disrupt Gag's interaction with cyclophilins, indicating that no other cyclophilin family members promote HIV-1 replication. (omicsdi.org)
  • In a successive evaluation of 12 putative mPT inhibiting compounds, none displayed effects comparable to cyclophilin D inhibition by the non-immunosuppressive cyclophilin inhibitor D-MeAla3-EtVal4-Cyclosporin (Debio 025). (lu.se)
Gene3
  • Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. (omicsdi.org)
  • Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (cdc.gov)
  • Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression. (cdc.gov)
Small molecule1
  • Structure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity. (omicsdi.org)
CyPs1
  • Cyclophilins (CyPs) are widely distributed in organisms, and play important roles. (nefu.edu.cn)
CypB1
  • We utilized biochemical purification methods and mass-spectrometric analysis to identify the M9-5 target as cyclophilin B (CypB). (duke.edu)
Recombinant1
  • Aβ_(25-35) (Sigma, USA), antibodies of Bcl-2 and Bax (Wuhan Boster, China), and recombinant human cyclophilin A (Biomol, USA) were used in this study. (imr.ac.cn)
Interacts1
  • Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (rochester.edu)
Prolyl1
  • The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein binds most members of the cyclophilin family of peptidyl-prolyl isomerases. (omicsdi.org)
Arabidopsis2
  • The anaCyp40 structure is distinct from that of other multi-domain cyclophilins (such as Arabidopsis thaliana Cyp38), and presents features that are absent in single-domain cyclophilins. (jascoinc.com)
  • Prokaryotic Expression,Activity Assay of Chlorella Cyclophilin A and Salt Tolerance Analysis of Arabidopsis Over-expressing CsCyp1A [J]. Bulletin of Botanical Research, 2017, 37(5): 722-729. (nefu.edu.cn)
Mice2
  • Compared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in response to IH challenge and fully preserved oligodendrocyte maturation, axonal myelination, and neurofunction. (jci.org)
  • Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone. (rochester.edu)
Replication2
  • These active compounds will be used as leads for structure and activity relationship (SAR) and optimization studies in order to design more effective anti-HIV-1 therapeutics, and as probes for investigating the effect of cyclophilins on HIV-1 replication. (omicsdi.org)
  • Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. (lumc.nl)
Functional1
  • These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophin A to initiate infection. (semanticscholar.org)
Survival1
  • Cyclophilin A enhanced the survival rate of PC12 cells to Aβ_(25-35)-induced apoptosis (t = 4.895, 10.042, P (imr.ac.cn)
Cells4
  • Porphyromonas gingivalis lipopolysaccharide and gingival fibroblast augment MMP-9 expression of monocytic U937 cells through cyclophilin A. (bvsalud.org)
  • Cells in the cyclophilin A group were incubated in medium containing a final con-centration of 10 nmol/L of cyclophilin A for 30 minutes, and then treated with 10 μmol/L Aβ_(25-35).MAIN OUTCOME MEASURES: After 24 hours of culture, immunohistochemistry was used to detect Bcl-2 and Bax expression in PC12 cells. (imr.ac.cn)
  • However, in PC12 cells treated with Aβ_(25-35) and cyclophilin A, Bcl-2 expression increased and Bax expression decreased (t = 4.497, 2.531, P (imr.ac.cn)
  • CONCLUSION: Cyclophilin A can increase Bcl-2 expression and decrease Bax expression in PC12 cells treated with Aβ_(25-35), which indicates that cyclophilin A has a protective effect on Aβ_(25-35)-induced injury to PC12 cells. (imr.ac.cn)
Domain2
  • Elucidation of the anaCyp40 crystal structure at 1.2-Å resolution reveals an N-terminal helical domain with similarity to PsbQ components of plant photosystem II, and a C-terminal cyclophilin domain with a substrate-binding site. (jascoinc.com)
  • Phylogenetic analysis showed the single-domain FKBPs to evolve prior to the multi-domain FKBPs, whereas the multi-domain cyclophilins appear to evolve throughout cyclophilin evolution. (biomedcentral.com)
Cell2
  • Human cyclophilins A and B are host cell proteins that bind specifically to the HIV-1 Gag polyprotein p55gag in vitro7. (semanticscholar.org)
  • Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. (duke.edu)
Role2
  • Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. (semanticscholar.org)
  • Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation. (rochester.edu)
Study1
  • Cyclophilin A-like was screened in our study from Chlorella sp. (nefu.edu.cn)
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