(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
A group of alicyclic hydrocarbons with the general formula R-C5H9.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.
A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.
Organic compounds containing a carbonyl group in the form -CHO.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and EP3 types based on their effects and their pharmacology.
Inorganic compounds that contain bromine as an integral part of the molecule.
Compounds that inhibit the action of prostaglandins.
Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).
Physiologically active prostaglandins found in many tissues and organs. They show pressor activity, are mediators of inflammation, and have potential antithrombotic effects.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
The B-cell leukemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 11.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.
A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
A potent vasodilator agent that increases peripheral blood flow.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GQ and the subsequently activates TYPE C PHOSPHOLIPASES. Additional evidence has shown that the receptor can act through a calcium-dependent signaling pathway.
Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.
A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. The most frequently encountered member of this group is the prostaglandin H2.
A subtype of prostaglandin E receptors that specifically couples to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI and subsequently inhibits ADENYLYL CYCLASES.
Precursors in the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. They are physiologically active compounds, having effect on vascular and airway smooth muscles, platelet aggregation, etc.
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another part of the same molecule. They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond (CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme Nomenclature, 1992) EC 5.3.
A colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
Tumors or cancer of the MOUTH.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cyclopentenone prostaglandins[edit]. Main article: Cyclopentenone prostaglandins. PGA1, PGA2, PGJ2, Δ12-PGJ2, and 15-deox-Δ12, ... Cyclopentenone prostaglandins include the following metabolites of arachidonic acid: *PGA1, PGA2 (see 'prostanoid, PGJ2, Δ12- ... doi:10.1016/j.prostaglandins.2011.09.001. PMID 21945326.. *^ Matsuoka T, Narumiya S (2007). "Prostaglandin receptor signaling ... And, the 5 member ring of the cyclopentenone prostaglandins possesses an unsaturated bond in a conjugated system with a ...
The PUFA-cyclopentenones include two prostaglandins, (PG) Δ12-PGJ2 and 15-deoxy-Δ12,14-PGJ2, and two isoprostanes, 5,6- ... prostaglandin E2 and prostaglandin D2) which instruct relevant cells to produce SPM and to assume a more anti-inflammatory ... Prostaglandins & Other Lipid Mediators. 97 (3-4): 73-82. doi:10.1016/j.prostaglandins.2012.01.005. PMID 22326554. Serhan CN, ... PUFA-cyclopentenones may likewise react with the IKK2 component of the cytosolic IKK2-NFκB protein complex thereby inhibiting ...
... are a subset of prostaglandins (PGs) or prostanoids (see eicosanoid#classic eicosanoids and ... The ability of cyclopentenone prostaglandins to promote the transcription of Nrf2-dependent genes appears critical to their ... The three PGJ2 cyclopentenone prostaglandins induce apoptosis in rodent cultured neuron cells by a mechanism that involves ... The PGJ2 series of cyclopentenone PGs bind to and activate the G protein-coupled receptor, Prostaglandin DP2 receptor, with 15- ...
The cyclopentenone prostaglandins, PGJ2, Δ12-PGJ2, and 15-d-Δ12,14-PGJ2 are spontaneously formed or protein-facilitated ... prostaglandin D receptor activity. • G-protein coupled receptor activity. • prostaglandin J receptor activity. • prostaglandin ... DP2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate ... "PTGDR2 prostaglandin D2 receptor 2". Gene Resources NCBI.. *^ a b Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T ...
Cyclopentenone prostaglandins may play a role in inhibiting inflammation Synthetic prostaglandins are used: To induce ... the most abundant prostaglandin - is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin ... prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α). Examples of prostaglandin antagonists are: ... "Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing ...
Cyclopentenones are found in a large number of natural products, including jasmone, the aflatoxins, and several prostaglandins ... The term cyclopentenone may also refer to a structural motif wherein the cyclopentenone moiety is a subunit of a larger ... "Process for preparing cyclopentenone", published 2004-11-25 Charles H. DePuy And K. L. Eilers (1962). "2-Cyclopentenone". Org. ... 2-Cyclopentenones can be synthesized in a number of ways. One of the routes involves elimination of α-bromo-cyclopentanone ...
Straus DS, Glass CK (2001). "Cyclopentenone prostaglandins: new insights on biological activities and cellular targets". ... Prostaglandin receptors Prostanoid receptors Prostaglandin DP2 receptor Eicosanoid receptor GRCh38: Ensembl release 89: ... see Cyclopentenone prostaglandins), also bind to and activate DP1, with PDJ2 doing so almost as effectively as PDG2 and the ... is primarily a receptor for prostaglandin D2 (PGD2). The receptor is a member of the Prostaglandin receptors belonging to the ...
The cyclopentenone prostaglandins, PGJ2, Δ12-PGJ2, and 15-d-Δ12,14-PGJ2 are spontaneously formed or protein-facilitated ... DP2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate ... Prostaglandin DP1 receptor Prostaglandin receptors Prostanoid receptors Eicosanoid receptor GRCh38: Ensembl release 89: ... Prostaglandins & Other Lipid Mediators. 75 (1-4): 153-67. doi:10.1016/j.prostaglandins.2004.11.003. PMID 15789622. Hata AN, ...
Cyclopentenone prostaglandins may play a role in inhibiting inflammation. Clinical usesEdit. Synthetic prostaglandins are used ... including prostaglandin I2 (prostacyclin; PGI2), prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α ... is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin H2, PGH2). Several prostaglandin E ... Prostaglandin E synthaseEdit. Prostaglandin E2 (PGE2) - the most abundant prostaglandin[7] - ...
The success of the Nazarov cyclization as a tool in organic synthesis stems from the utility and ubiquity of cyclopentenones as ... both motifs in natural products (including jasmone, the aflatoxins, and a subclass of prostaglandins) and as useful synthetic ... The key step of the reaction mechanism involves a cationic 4π-electrocyclic ring closure which forms the cyclopentenone product ... Subsequent tautomerization of the enolate produces the cyclopentenone product. As noted above, variants that deviate from this ...
CS1 maint: Multiple names: authors list (link) Corey, E. J. Arnold, Z. Hutton, J. (1970). "Total synthesis of prostaglandins E2 ... Photochemical rearrangement of 4-aryl-substituted cyclopentenones. Low-temperature photochemistry and direct observation of ... cyclization in synthesizing the prostaglandins. Robert Ireland's synthesis of (±)-aphidicolin uses the Wolff rearrangement to ...
Cyclopentenone prostaglandins are a subset of prostaglandins (PGs) or prostanoids (see eicosanoid#classic eicosanoids and ... The ability of cyclopentenone prostaglandins to promote the transcription of Nrf2-dependent genes appears critical to their ... The three PGJ2 cyclopentenone prostaglandins induce apoptosis in rodent cultured neuron cells by a mechanism that involves ... The PGJ2 series of cyclopentenone PGs bind to and activate the G protein-coupled receptor, Prostaglandin DP2 receptor, with 15- ...
The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes. Nolan K. Maier, Stephen H. Leppla and ... The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes Message Subject (Your Name) has forwarded ... The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes ... The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes ...
Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ(12,14)-prostaglandin J2 (15dPGJ2), are reactive prostaglandin ... The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: ... The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: ... The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: ...
Antineoplastic effects of cyclopentenone prostaglandins, especially 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), have been ... Abrogation of IL-6-mediated JAK/STAT signaling by the cyclopentenone prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in oral ... Abrogation of IL-6-mediated JAK/STAT signaling by the cyclopentenone prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in oral ... Abrogation of IL-6-mediated JAK/STAT signaling by the cyclopentenone prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in oral ...
... Nature. 2000 Jan 6;403(6765):103-8. doi ... Cyclopentenone prostaglandins have been suggested to exert anti-inflammatory activity through the activation of peroxisome ... At late stages of inflammatory episodes, however, COX2 directs the synthesis of anti-inflammatory cyclopentenone prostaglandins ... our findings explain how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors. ...
... * QMRO Home ... Previous work in our department showed a role for COX-2 derived PGD2 and its cyclopentenone metabolite 15d-PGJ2 during ...
Cyclopentenone prostaglandins[edit]. Main article: Cyclopentenone prostaglandins. PGA1, PGA2, PGJ2, Δ12-PGJ2, and 15-deox-Δ12, ... Cyclopentenone prostaglandins include the following metabolites of arachidonic acid: *PGA1, PGA2 (see prostanoid, PGJ2, Δ12- ... doi:10.1016/j.prostaglandins.2011.09.001. PMID 21945326.. *^ Matsuoka T, Narumiya S (2007). "Prostaglandin receptor signaling ... And, the 5 member ring of the cyclopentenone prostaglandins possesses an unsaturated bond in a conjugated system with a ...
Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins ... Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins ... Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins ...
title = "Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation ... T1 - Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation ... Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation ... Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation ...
Cyclopentenone prostaglandins are TRPA1 agonists. 15d-PGJ2 is a major cyclopentenone prostaglandin produced nonenzymatically by ... and by the cyclopentenone prostaglandin, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2, EC50: 5.6 μM). The effect of H2O2 was ... Finally cyclopentenone prostaglandins (cyPGs), produced from arachidonic acid via cyclooxygenase and prostaglandin D2 (PGD2) ... Cyclopentenone prostaglandins of the A and J series are produced in vivo by dehydration of the pentane ring of the ...
The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T ... The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T ... 15-Deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) is a cyclopentenone-type PG endowed with anti-inflammatory properties and produced by ... 15-Deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) is a cyclopentenone-type PG endowed with anti-inflammatory properties and produced by ...
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403, 103-108 (2000) ...
The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.. Maier NK, Leppla SH, Moayeri M. ...
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 2000. 403:103-108. View this ... Downregulation of the NF-κB pathway by cyclopentenone prostaglandins. NF-κB regulates the expression of a variety of genes ... Downregulation of the NF-κB pathway by cyclopentenone prostaglandins. *Inhibition of proteasome function prevents IκB ... Downregulation of the NF-κB pathway by cyclopentenone prostaglandins. *Inhibition of proteasome function prevents IκB ...
Cyclopentenone Prostaglandins: Agonists and Antagonists of Apoptosis. L. Jackson Roberts, Vanderbilt University, USA Reactive ... Products of the Isoprostane Pathway, Isoketals and Cyclopentenone Isoprostanes, Covalently Modify Key Cellular Proteins that ...
"Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-δ prostaglandin J2-induced ... A. Rossi, P. Kapahi, G. Natoli et al., "Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase," ... Among the prostaglandin species, 15-deoxy-Δ12-14 prostaglandin J2 (15d-PGJ2) is a downstream metabolite of PGD2 that acts by ... E. M. Brunoldi, G. Zanoni, G. Vidari et al., "Cyclopentenone prostaglandin, 15-deoxy-Δ12,14-PGJ2, is metabolized by HepG2 cells ...
Straus DS, Glass CK (2001). "Cyclopentenone prostaglandins: new insights on biological activities and cellular targets". ... Prostaglandin receptors Prostanoid receptors Prostaglandin DP2 receptor Eicosanoid receptor GRCh38: Ensembl release 89: ... see Cyclopentenone prostaglandins), also bind to and activate DP1, with PDJ2 doing so almost as effectively as PDG2 and the ... is primarily a receptor for prostaglandin D2 (PGD2). The receptor is a member of the Prostaglandin receptors belonging to the ...
... catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The ... Particularly, the chiral 2,4-disubstituted cyclopentenones as prostaglandins have anti-inflammatory [50], anticancer [51], and ... As previously observed [57,60], the conversion of 4,5-diamino cyclopentenone to 2,4-diamino cyclopentenone was performed in the ... Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 2000, 403, 103-118. [Google Scholar ...
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 2000. 403:103-118. View this ... Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. J. Biol. ... Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy- ... Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert ...
Prostaglandins with cyclopentenone structure (cyPG) display potent antiproliferative actions that have elicited their study as ... Cyclopentenone prostaglandins. proteomic identification. Michael addition. vimentin. cytoskeleton. inhibition of proliferation ... In previous work, we have observed that a biotinylated analog of PGA1 that retains the cyclopentenone moiety (PGA1-B) binds to ... Several natural and synthetic analogs of the cyPG prostaglandin A1 (PGA1) have proven antitumoral efficacy in cancer cell lines ...
Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Lett. 508:61. ... Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 100:1354. ... Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98:1942. ... Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane ...
Modification of cysteine residues by cyclopentenone prostaglandins in the elucidation of redox regulation of protein function ...
Cuzzocrea S, Wayman NS, Mazzon E, et al. The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 attenuates the ... Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 2001;21:185-210. ... Cuzzocrea S, Ianaro A, Wayman NS, et al. The cyclopentenone prostaglandin 15-deoxy-Δ12,14-PGJ2 attenuates the development of ... Several members of the cyclopentenone family of prostaglandins (PGs) possess antineoplastic, antiviral and anti-inflammatory ...
Straus DS, Glass CK (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res ...
Cyclopentenone prostaglandins are potent inhibitors of virus replication. The antiviral activity has been associated with the ... Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis.. C ... Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis. ... Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis. ...
Role of cyclopentenone prostaglandins in rat carrageenin pleurisy:;. FEBS Lett 508, 61. 2001 [PMID: 11707269] (WB, GS) WB, GS. ...
65 Cyclopentenone Prostaglandins: Anti-Proliferative and Anti-Viral Actions and Their Molecular Mechanism.- 66 Membrane- ... 19 Absence of Prostaglandin E2-lnduced Radioprotection in Two Cell Lines Lacking Specific PGE2-Binding Sites.- 20 Radiation- ... Phosphothreonine and Prostaglandins in a Rat Transplantable Hepatoma and Prostatic Tumor.- 52 Role of Arachidonic and Linoleic ... 16-Dimethyl Prostaglandin E2 Pretreatment and/or Bone Marrow Transplantation After Supra-Lethal Whole Body Irradiation.- 59 ...
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 403:103-108. doi:10.1038/47520 ... prostaglandin D2. PGE2. prostaglandin E2. PLA2. phospholipase A2. PLA2G2D. group IID sPLA2. PUFA. polyunsaturated fatty acid. ... 15-deoxy-Δ12,14-prostaglandin J2. AA. arachidonic acid. BMDC. BM-derived DC. CHS. contact hypersensitivity. cPLA2. Ca2+- ... Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity. J. Immunol. 184:5595- ...
Thioredoxin as a molecular target of cyclopentenone prostaglandins. J. Biol. Chem. 278:26046-26054. ... Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Δ12,14-prostaglandin J2. Mol. Cell. Biol. ... Chemical reagents.MG132, tert-butyl hydroquinone (tBHQ), 15d-prostaglandin J2 (15d-PGJ2), and cycloheximide (CHX) were ...
Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J. Biol. Chem. 276:12076-12083. ... Prostaglandin J2 is known to induce oxidative stress by causing decreases in glutathione, glutathione peroxidase, and ... Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 ... for the sequestration of ubiquitinated proteins into bodies in response to treatment with the inflammatory agent prostaglandin ...
  • The findings reported in this study suggest a novel mechanism for the anti-inflammatory properties of the cyclopentenone PGs through inhibition of caspase-1 and the inflammasome. (jimmunol.org)
  • Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis. (asm.org)
  • We investigated a new role for prostaglandin A1 (PGA1) in the inhibition of hepatitis C virus (HCV)-IRES-mediated translation. (sigmaaldrich.com)
  • PGD2 conversions form the most studied cyclopentenone PGs. (wikipedia.org)
  • H2O]) across its 9-hydroxyl-carbon 10 region to form a new 9,10 double bond to become PGJ2 possessing a cyclopentenone ring (i.e. the ring contains one double bond) replacing the cyclopentanone ring (i.e. the ring has no double bonds) of PGD2. (wikipedia.org)
  • Previous work in our department showed a role for COX-2 derived PGD2 and its cyclopentenone metabolite 15d-PGJ2 during resolution in a pleurisy model. (qmul.ac.uk)
  • The Prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR1 gene (also termed PTGDR), is primarily a receptor for prostaglandin D2 (PGD2). (wikipedia.org)
  • PGE2>Prostaglandin F2alpha>PGI2=thromboxane A2, with PGD2 being more than 100-fold more potent than PGE2 in binding to and stimulating DP1. (wikipedia.org)
  • PDJ2, Δ12-PDJ2, and 15-deoxy-Δ12,14-PGJ2, which form in vitro and in vivo rapidly as non-enzymatic rearrangements of PGD2 (see Cyclopentenone prostaglandins), also bind to and activate DP1, with PDJ2 doing so almost as effectively as PDG2 and the latter two PGJs doing so 100-fold and 300-fold less potently than PDG2. (wikipedia.org)
  • DP 2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). (wikipedia.org)
  • Studies suggest that at least some if not most or all of the cytotoxic effects of cylopenenone prostaglandin derivatives of PGD2 act independently of DP2. (wikipedia.org)
  • Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ(12,14)-prostaglandin J2 (15dPGJ2), are reactive prostaglandin metabolites exerting a variety of biological effects. (nih.gov)
  • Previous studies have demonstrated that cyclopentenone prostaglandins (cyPGs) inhibit the replication of a wide variety of DNA and RNA viruses in different mammalian cell types. (sigmaaldrich.com)
  • Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. (omega-research.com)
  • Previous research from Graham's lab had provided some hints as to UCHL1's function, showing that cyclopentenone prostaglandins (CyPgs) - fatty acid molecules-released in nerve cells after a stroke bind to UCHL1 and impair its function. (medicalxpress.com)
  • Freed NF-kappaB dimers translocate to the nucleus and induce target genes, including the one for cyclo-oxygenase 2 (COX2), which catalyses the synthesis of pro-inflammatory prostaglandins, in particular PGE. (nih.gov)
  • At late stages of inflammatory episodes, however, COX2 directs the synthesis of anti-inflammatory cyclopentenone prostaglandins, suggesting a role for these molecules in the resolution of inflammation. (nih.gov)
  • A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. (mdpi.com)
  • In this report, we describe that in African green monkey kidney cells infected with Sendai virus (SV) and treated with prostaglandin A1 (PGA1), SV protein synthesis was selectively blocked as long as HSP70 was being synthesized by the host cell. (asm.org)
  • We hypothesised that these inflammatory cells express cyclooxygenase 2 (COX-2), an enzyme that contributes to the synthesis of pro and anti-inflammatory prostaglandins and is known to be expressed at sites of inflammation in the stomach and colon. (bmj.com)
  • A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. (edu.au)
  • This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. (patents.com)
  • Studies directed toward the Synthesis of Prostaglandins. (patents.com)
  • One-Pot Synthesis of Protected Prostaglandins from Alkynes and Cyclopentenones, In Situ Generation of Higher Order Cyanocuprates Derived from Alkenylzirconium Intermediates," J. Am. Chem. (patents.com)
  • Synthesis of Prostaglandin Models and Prostaglandins by Conjugate Addition of a Functionalized Organocopper Reagent," J. Am. Chem. (patents.com)
  • 4) represses mPGES expression induced by IL-1α and the synthesis of PGE 2 and induces the synthesis of 15-deoxy-Δ 12,14-prostaglandin J 2 (15ΔPGJ 2 ). (biomedcentral.com)
  • The receptor is a member of the Prostaglandin receptors belonging to the Subfamily A14 of rhodopsin-like receptors. (wikipedia.org)
  • The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. (hindawi.com)
  • It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins . (wikipedia.org)
  • Prostaglandins mediate their effects through transmembrane G-protein-coupled receptors, several of which exist for each PG (12) . (onlinejacc.org)
  • 15-Deoxy-Delta(12,14)-prostaglandin-J(2) (15d-PGJ(2)) is a cyclopentenone prostaglandin regarded as antiinflammatory mediator, which can act through peroxisome proliferator-activated receptor-gamma (PPARgamma) or through G protein-coupled surface receptors. (sigmaaldrich.com)
  • Cyclopentenone prostaglandins are a subset of prostaglandins (PGs) or prostanoids (see eicosanoid#classic eicosanoids and eicosanoid#nonclassic eicosanoids) that has 15-deoxy-Δ12,14-prostaglandin J2 (15-d-Δ12,14-PGJ2), Δ12-PGJ2, and PGJ2 as its most prominent members but also including PGA2, PGA1, and, while not classified as such, other PGs. (wikipedia.org)
  • This electrophilic site is probably less electrophilic that the carbon 9 sites of Δ12-PGJ2 and 15-deoxy-Δ12-PGJ2 The cyclopentenone structures of PGA2, PGA1, PGJ2, Δ12-PGJ2, and 15-d-Δ12,14-PGJ2 possess α,β-unsaturated carbonyl groups (see Carbonyl group#α,β-Unsaturated carbonyl compounds) which serve to establish high levels of chemical reactivity at nearby carbons 9, 11, and/or 13. (wikipedia.org)
  • Several natural and synthetic analogs of the cyPG prostaglandin A1 (PGA1) have proven antitumoral efficacy in cancer cell lines and animal models. (csic.es)
  • In previous work, we have observed that a biotinylated analog of PGA1 that retains the cyclopentenone moiety (PGA1-B) binds to multiple targets in fibroblasts. (csic.es)
  • This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield. (patents.com)
  • Considerable interest has arisen in cyclopentenone derivatives of prostaglandins ( 6 ), particularly 15dPGJ 2 , which has been described as an active compound in cancer ( 7 )( 8 ) and in cell apoptosis ( 9 )( 10 ), in addition to adipogenesis ( 11 ). (aaccjnls.org)
  • The resulting derivatives were MOX,PFB,TMS-prostaglandins. (aaccjnls.org)
  • Despite the growing interest in this prostaglandin metabolite, no reliable assay has been reported, especially by gas chromatography-mass spectrometry (GC-MS), a reference method for prostanoids ( 13 ). (aaccjnls.org)
  • Moreover, 9,10-dihydro-15d-PGJ 2 failed to inhibit JAK and Stat3 phosphorylation, suggesting that the repression of IL-6 mediated JAK/Stat3 signaling by 15d-PGJ 2 requires the reactive α,β-unsaturated carbon within the cyclopentenone ring. (aacrjournals.org)
  • We show that 15d-PGJ(2) inhibits fas-L mRNA expression, activation-induced cell death, and fas-L promoter activity by mechanisms independent of PPARgamma and mediated by its chemically reactive cyclopentenone moiety. (uniba.it)
  • These J2 prostaglandins are highly reactive and neurotoxic products of inflammation shown in cellular models to impair the ubiquitin/proteasome pathway and cause the accumulation of ubiquitinated proteins. (biomedcentral.com)
  • Our novel PGJ2-induced PD model strongly supports the view that localized and chronic production of highly reactive and neurotoxic prostaglandins, such as PGJ2, in the CNS could be an integral component of inflammation triggered by insults evoked by physical, chemical or microbial stimuli and thus establishes a link between neuroinflammation and PD neurodegeneration. (biomedcentral.com)
  • Cyclopentenone prostaglandins (cyPG) are endogenous reactive lipid mediators that participate in the regulation ofinflammation and may covalently modify proteins through Michael addition. (chemweb.com)
  • 15-d-Δ12,14-PGJ2, Δ12-PGJ2, and PGJ2 share a common mono-unsaturated cyclopentenone structure as well as a set of similar biological activities including the ability to suppress inflammation responses and the growth as well as survival of cells, particularly those of cancerous or neurological origin. (wikipedia.org)
  • There is recent evidence that the cyclopentenone PG 15d-PGJ 2 may also play a therapeutic role in conditions associated with inflammation 10 , 11 . (ersjournals.com)
  • Prostaglandins (PG) regulate diverse biological functions during both homeostasis and inflammation. (aacrjournals.org)
  • Inflammation involves the activation of microglia and astrocytes that release high levels of prostaglandins. (biomedcentral.com)
  • The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. (cancerindex.org)
  • Here, we have identified that cyclopentenone-containing prostaglandins such as 15d-PGJ2 and structurally related oxidized phospholipid species possess a dual and opposing bioactivity in inflammation, depending on their concentration. (datacite.org)
  • PGJ 2 is formed by dehydration within the cyclopentane ring of the endogenous prostaglandin, PGD 2 , and is further metabolised to yield Δ 12 -PGJ 2 and 15-deoxy-Δ 12,14 -PGJ 2 (15d-PGJ 2 ) 5 . (ersjournals.com)
  • 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a terminal dehydration product of prostaglandin D(2), is an endogenous ligand of peroxisome proliferator-activated receptor-gamma and exhibits a number of biological activities including the proapoptotic activity. (snu.ac.kr)
  • 15-Deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) is a cyclopentenone-type PG endowed with anti-inflammatory properties and produced by different cells, including those of the immune system. (uniba.it)
  • Several members of the cyclopentenone family of prostaglandins (PGs) possess antineoplastic, antiviral and anti-inflammatory properties 5 . (ersjournals.com)
  • sup.7-Prostaglandin C.sub.1: A Primary Metabolite of Antitumor .DELTA. (patents.com)
  • Prostaglandin D 2 (PGD 2 ) together with its positional isomer PGE 2 is a direct metabolite of PGH 2 arising from the dioxygenation of arachidonic acid ( 1 ). (aaccjnls.org)
  • We addressed the neurodegenerative and behavioral effects of the administration of prostaglandin J2 (PGJ2) simultaneously into the substantia nigra / striatum of adult male FVB mice by subchronic microinjections. (biomedcentral.com)
  • The J-series prostaglandins PGJ2 and [Delta]12PGJ2 are structural isomers that differ in the position of a single double bond. (uncg.edu)
  • The goal of this project is to differentiate the prostaglandin isomers PGJ2 and [Delta]12PGJ2 using a variety of MS/MS methods. (uncg.edu)
  • Cyclopentenone prostaglandins have been suggested to exert anti-inflammatory activity through the activation of peroxisome proliferator-activated receptor-gamma. (nih.gov)
  • Among them, the 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) regulates the activity of three transcription factors playing a central role in stress response, differentiation and proliferation: the peroxisome proliferator-activated receptor γ (PPAR γ ), the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), and the nuclear factor κ B (NF- κ B) [ 2 ]. (hindawi.com)
  • Thiazolidinedione rosiglitazone and 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), are two peroxisome proliferator-activated receptor (PPAR)-γ ligands. (ersjournals.com)
  • These results demonstrate that the two peroxisome proliferator-activated receptor-γ agonists, rosiglitazone and 15-deoxy-Δ 12,14 -prostaglandin J 2 , significantly reduce lung injury induced by bleomycin in mice. (ersjournals.com)
  • Il-1β and prostaglandin E2 attenuate the hypercapnic as well as the hypoxic respiratory response via prostaglandin E receptor type 3 in neonatal mice. (semanticscholar.org)
  • Prostaglandin D 2 receptor 2 ( DP 2 or CRTH2 ) is a human protein encoded by the PTGDR2 gene and GPR44. (wikipedia.org)
  • Cyclopentenone J-series prostaglandins and prostaglandin-ethanolamide conjugates have been shown to selectively induce endoplasmic reticulum stress-apoptosis in different cancer cell types. (uncg.edu)
  • Prostaglandins with cyclopentenone structure (cyPG) display potent antiproliferative actions that have elicited their study as potential anticancer agents. (csic.es)
  • Cyclopentenone prostaglandins are potent inhibitors of virus replication. (asm.org)
  • Antineoplastic effects of cyclopentenone prostaglandins, especially 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), have been reported in various types of cancer. (aacrjournals.org)
  • We report that the eicosanoid 15-deoxy-Δ 12,14 -PGJ 2 (15d-PGJ 2 ) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes. (jimmunol.org)
  • Vasodilator-stimulated phosphoprotein (VASP), a family member of proline-rich proteins, was first characterized as a major phosphorylated protein in platelets and endothelial cells after stimulation with vasodilators such as prostaglandins and NO donors. (ahajournals.org)
  • p38 Mitogen Activated Protein Kinase (p38) activation, Nuclear Factor-kappaB (NF-kB) activation and Prostaglandin E 2 (PGE 2 ) quantitation were performed by commercially available assays. (biomedcentral.com)
  • The major prostaglandin in the mammalian brain is prostaglandin D2, which readily undergoes spontaneous dehydration to generate the bioactive cyclopentenone prostaglandins of the J2 series. (biomedcentral.com)
  • Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins. (patents.com)
  • Cyclooxygenases 1 (COX-1) and 2 (COX-2) mediate conversion of arachidonic acid to prostaglandin G 2 which is then metabolised to prostaglandin H 2 and a number of other compounds, including various prostaglandins and thromboxanes. (bmj.com)
  • The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. (patents.com)
  • These latter compounds can undergo nonenzymatic hydrolysis forming α - or γ -ketols, or can be channeled into the generation of cyclic, prostaglandin-like cyclopentenones through enzymatic cyclization by allene oxide cyclases. (plantphysiol.org)
  • We are exploring avenues for exploiting the powerful anti-tumour activities of the cyclopentenone prostaglandin 15deoxy Delta 12,14 PGFJ 2 in leukaemia cells. (birmingham.ac.uk)
  • There is a profound gap in our understanding of how cyclooxygenases and their prostaglandin products redirect cellular events to promote PD neurodegeneration. (biomedcentral.com)
  • The differentiation of these prostaglandins is an important step in the elucidation of the metabolic pathway mediated by COX-2 and the mechanism of action of the downstream products. (uncg.edu)
  • Prostaglandins are generated from arachidonic acid by the enzyme COX, which has two isoforms: COX-1 and COX-2. (onlinejacc.org)
  • Due to the variety of prostaglandins presently known, it is reasonable to speculate that these lipid mediators might play different roles in the CNS. (hindawi.com)
  • Proposed intrarenal roles for vasodilatory prostaglandins (PGs) to regulate renal function and blood pressure control. (comprehensivephysiology.com)
  • Lipidomics analysis revealed that PLA2G2D in the LNs contributed to mobilization of a pool of polyunsaturated fatty acids that could serve as precursors for antiinflammatory/pro-resolving lipid mediators such as resolvin D1 and 15-deoxy-Δ 12,14 -prostaglandin J 2 , which reduced Th1 cytokine production and surface MHC class II expression in LN cells or DCs. (rupress.org)
  • Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-delta7-prostaglandin A1 methyl ester (TEI-9826) integrated in lipid microspheres (Lipo TEI-9826). (patents.com)
  • The dried lipid extracts were purified by thin-layer chromatography with chloroform-methanol-acetic acid (90:5:2 by volume) as mobile phase to separate 15dPGJ 2 from its parent prostaglandins ( 2 ). (aaccjnls.org)
  • The cyclopenentone prostaglandins are structurally and functionally related to a subset of isoprostanes viz. (wikipedia.org)
  • To date, three prostaglandin (PG) E synthases (PGESs) have been characterized: the microsomal PGESs (mPGES-1 and mPGES-2) and the cytosolic PGES (cPGES) [ 11 - 14 ]. (hindawi.com)
  • Both COX‐1 and COX‐2 convert AA to PGH 2 , which is then acted upon by specific synthases to produce thromboxane A 2 or specific prostaglandins (PGs). (comprehensivephysiology.com)
  • 5. The stent of claim 2 wherein said stent substrate and said polymer mixture are water soluble and resorbable, providing a continuous and gradual release of prostaglandin encapsulated in said biologically active microspheres. (google.com)
  • 6. The stent of claim 1 wherein the pores of said stent substrate define an irregular pore surface for releaseably retaining said biologically active microspheres, and wherein said microspheres contain prostaglandin E1 encapsulated in said microspheres. (google.com)
  • 8. The stent of claim 7 wherein said microspheres release prostaglandin E1 at a controlled rate for up to six months. (google.com)
  • Recent studies have revealed that this cyclopentenone prostaglandin, at non-toxic concentrations, can also exert antiapoptotic or cytoprotective effects. (snu.ac.kr)
  • Human myeloid cell lines at different stages of differentiation (K562, HL60 and U937) were used to analyze the permissivity of the myelomonocytic lineage to acute infection with human T-cell leukemia virus type-I (HTLV-I) after cell-to-cell transmission and to evaluate the effect of cyclopentenone prostaglandins (PG)A 1 and PGJ 2 on virus transmission, proliferation of recipient cells and cell-mediated cytotoxicity against virus-donor cells. (elsevier.com)
  • This prostaglandin modulates the expression of inflammatory mediators by microglial cells. (hindawi.com)
  • Herein, we review the current knowledge on the role of prostaglandins, as well as the enzymes that synthesize them, in neuroinflammatory and neurodegenerative diseases. (hindawi.com)
  • The role of J2 prostaglandins in promoting PD neurodegeneration has not been investigated under in vivo conditions. (biomedcentral.com)
  • In addition, the activation/expression of the heat shock response genes HSF-1 and HSP70 is not directly involved in the repression, and the electrophilic molecule cyclopentenone (2-cyclopenten-1-one) may reproduce the effects mediated by 15d-PGJ(2). (uniba.it)
  • The release of prostaglandins from lung and other tissues. (asmscience.org)
  • As IKKbeta is responsible for the activation of NF-kappaB by pro-inflammatory stimuli, our findings explain how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors. (nih.gov)
  • Among the different inflammatory mediators involved, prostaglandins play an important role. (hindawi.com)
  • Inflammatory Resolution: The Role of Cyclopentenone Prostaglandins, Adenosine and Lymphocyte Trafficking. (qmul.ac.uk)
  • Proposed role of prostaglandins (PGs) as a modulator of the renin‐angiotensin system. (comprehensivephysiology.com)
  • In the case of the formation of COX products, particularly prostaglandin E 2 (PGE 2 ) and PGD 2 , humans have evolved two sets of biosynthetic enzymes that differ not only in their cell- and tissue-specific localization, but also in their subcellular localization and requirement for reduced glutathione, a cellular defense against oxidative damage. (jci.org)
  • In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases. (hindawi.com)
  • While techniques such as ELISA and UV-Vis spectroscopy can detect these molecules based on their class, they fail to offer the specificity necessary to differentiate those prostaglandins that are isomeric in structure. (uncg.edu)