Cyclohexane ring substituted by one or more ketones in any position.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
Ordered compilations of item descriptions and sufficient information to afford access to them.
A country spanning from central Asia to the Pacific Ocean.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
Organizations established by endowments with provision for future maintenance.
The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
A plant genus of the family ASTERACEAE. Members contain CAROTENOIDS, essential oils (OILS, VOLATILE), flavonoids, mucilage, SAPONINS, and STEROLS. The plants are used both topically and internally. The common name of Marigold is also used for TAGETES.
Cyclic compounds with a ring size of approximately 1-4 dozen atoms.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.
The giving of drugs, chemicals, or other substances by mouth.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
The application of suitable drug dosage forms to the skin for either local or systemic effects.

Characterisation of the conformational and quaternary structure-dependent heparin-binding region of bovine seminal plasma protein PDC-109. (1/410)

PDC-109, the major heparin-binding protein of bull seminal plasma, binds to sperm choline lipids at ejaculation and modulates capacitation mediated by heparin. Affinity chromatography on heparin-Sepharose showed that polydisperse, but not monomeric, PDC-109 displayed heparin-binding capability. We sought to characterise the surface topology of the quaternary structure-dependent heparin-binding region of PDC-109 by comparing the arginine- and lysine-selective chemical modification patterns of the free and the heparin-bound protein. A combination of reversed-phase peptide mapping of endoproteinase Lys-C-digested PDC-109 derivatives and mass spectrometry was employed to identify modified and heparin-protected residues. PDC-109 contains two tandemly arranged fibronectin type II domains (a, Cys24-Cys61; b, Cys69-Cys109). The results show that six basic residues (Lys34, Arg57, Lys59, Arg64, Lys68, and Arg104) were shielded from reaction with acetic anhydride and 1,2-cyclohexanedione in heparin-bound PDC-109 oligomers. In the 1H-NMR solution structures of single fibronectin type II domains, residues topologically equivalent to PDC-109 Arg57 (Arg104) and Lys59 lay around beta-strand D on the same face of the domain. In full-length PDC-109, Arg64 and Lys68 are both located in the intervening polypeptide between domains a and b. Our data suggest possible quaternary structure arrangements of PDC-109 molecules to form a heparin-binding oligomer.  (+info)

Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. (2/410)

BACKGROUND: Oxalate, a common constituent of kidney stones, is cytotoxic for renal epithelial cells. Although the exact mechanism of oxalate-induced cell death remains unclear, studies in various cell types, including renal epithelial cells, have implicated phospholipase A2 (PLA2) as a prominent mediator of cellular injury. Thus, these studies examined the role of PLA2 in the cytotoxic effects of oxalate. METHODS: The release of [3H]-arachidonic acid (AA) or [3H]-oleic acid (OA) from prelabeled Madin-Darby canine kidney (MDCK) cells was measured as an index for PLA2 activity. The cell viability was assessed by the exclusion of ethidium homodimer-1. RESULTS: Oxalate exposure (175 to 550 microM free) increased the release of [3H]-AA in MDCK cells but had no effect on the release of [3H]-OA. Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2. The [3H]-AA release could be demonstrated within 15 minutes after exposure to oxalate, which is considerably earlier than the observed changes in cell viability. Furthermore, AACOCF3 significantly reduced oxalate toxicity in MDCK cells. CONCLUSIONS: Oxalate increases AA release from MDCK cells by a process involving cPLA2. In addition, based on the evidence obtained using a selective inhibitor of this isoform, it would appear that the activity of this enzyme is responsible, at least in part, for the cytotoxic effects of oxalate. The finding that oxalate can trigger a known lipid-signaling pathway may provide new insight into the initial events in the pathogenesis of nephrolithiasis.  (+info)

Purification and characterization of monovalent cation-activated levodione reductase from Corynebacterium aquaticum M-13. (3/410)

(6R)-2,2,6-Trimethyl-1,4-cyclohexanedione (levodione) reductase was isolated from a cell extract of the soil isolate Corynebacterium aquaticum M-13. This enzyme catalyzed regio- and stereoselective reduction of levodione to (4R,6R)-4-hydroxy-2,2, 6-trimethylcyclohexanone (actinol). The relative molecular mass of the enzyme was estimated to be 142,000 Da by high-performance gel permeation chromatography and 36,000 Da by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme required NAD(+) or NADH as a cofactor, and it catalyzed reversible oxidoreduction between actinol and levodione. The enzyme was highly activated by monovalent cations, such as K(+), Na(+), and NH(4)(+). The NH(2)-terminal and partial amino acid sequences of the enzyme showed that it belongs to the short-chain alcohol dehydrogenase/reductase family. This is the first report of levodione reductase.  (+info)

Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases. (4/410)

The genes encoding flavin mononucleotide-containing oxidoreductases, designated xenobiotic reductases, from Pseudomonas putida II-B and P. fluorescens I-C that removed nitrite from nitroglycerin (NG) by cleavage of the nitroester bond were cloned, sequenced, and characterized. The P. putida gene, xenA, encodes a 39,702-Da monomeric, NAD(P)H-dependent flavoprotein that removes either the terminal or central nitro groups from NG and that reduces 2-cyclohexen-1-one but did not readily reduce 2,4,6-trinitrotoluene (TNT). The P. fluorescens gene, xenB, encodes a 37,441-Da monomeric, NAD(P)H-dependent flavoprotein that exhibits fivefold regioselectivity for removal of the central nitro group from NG and that transforms TNT but did not readily react with 2-cyclohexen-1-one. Heterologous expression of xenA and xenB was demonstrated in Escherichia coli DH5alpha. The transcription initiation sites of both xenA and xenB were identified by primer extension analysis. BLAST analyses conducted with the P. putida xenA and the P. fluorescens xenB sequences demonstrated that these genes are similar to several other bacterial genes that encode broad-specificity flavoprotein reductases. The prokaryotic flavoprotein reductases described herein likely shared a common ancestor with old yellow enzyme of yeast, a broad-specificity enzyme which may serve a detoxification role in antioxidant defense systems.  (+info)

N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. (5/410)

E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays a role in maintaining the normal phenotype of epithelial cells. Decreased expression of E-cadherin has been correlated with increased invasiveness of breast cancer. In other systems, inappropriate expression of a nonepithelial cadherin, such as N-cadherin, by an epithelial cell has been shown to downregulate E-cadherin expression and to contribute to a scattered phenotype. In this study, we explored the possibility that expression of nonepithelial cadherins may be correlated with increased motility and invasion in breast cancer cells. We show that N-cadherin promotes motility and invasion; that decreased expression of E-cadherin does not necessarily correlate with motility or invasion; that N-cadherin expression correlates both with invasion and motility, and likely plays a direct role in promoting motility; that forced expression of E-cadherin in invasive, N-cadherin-positive cells does not reduce their motility or invasive capacity; that forced expression of N-cadherin in noninvasive, E-cadherin-positive cells produces an invasive cell, even though these cells continue to express high levels of E-cadherin; that N-cadherin-dependent motility may be mediated by FGF receptor signaling; and that cadherin-11 promotes epithelial cell motility in a manner similar to N-cadherin.  (+info)

A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis. (6/410)

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and committed step in glycerolipid biosynthesis. We previously cloned the cDNA sequence to murine mitochondrial GPAT (Yet, S-F., Lee, S., Hahm, Y. T., and Sul, H.S. (1993) Biochemistry 32, 9486-9491). We expressed the protein in insect cells which was targeted to mitochondria, purified, and reconstituted mitochondrial GPAT activity using phospholipids (Yet, S.-F., Moon, Y., and Sul, H. S. (1995) Biochemistry 34, 7303-7310). Deletion of the seven amino acids from mitochondrial GPAT, (312)IFLEGTR(318), which is highly conserved among acyltransferases in glycerolipid biosynthesis, drastically reduced mitochondrial GPAT activity. Treatment of mitochondrial GPAT with arginine-modifying agents, phenylglyoxal and cyclohexanedione, inactivated the enzyme. Two highly conserved arginine residues, Arg-318, in the seven amino stretch, and Arg-278, were identified. Substitution of Arg-318 with either alanine, histidine, or lysine reduced the mitochondrial GPAT activity by over 90%. On the other hand, although substitution of Arg-278 with alanine and histidine decreased mitochondrial GPAT activity by 90%, replacement with lysine reduced activity by only 25%. A substitution of the nonconserved Arg-279 with either alanine, histidine, or lysine did not alter mitochondrial GPAT activity. Moreover, R278K mitochondrial GPAT still showed sensitivity to arginine-modifying agents, as in the case of wild-type mitochondrial GPAT. These results suggest that Arg-318 may be critical for mitochondrial GPAT activity, whereas Arg-278 can be replaced by a basic amino acid. Examination of the other conserved residues in the seven amino acid stretch revealed that Phe-313 and Glu-315 are also important, but conservative substitutions can partially maintain activity; substitution with alanine reduced activity by 83 and 72%, respectively, whereas substituting Phe-313 with tyrosine and Glu-315 with glutamine had even lesser effect. In addition, there was no change in fatty acyl-CoA selectivity. Kinetic analysis of the R318K and R318A mitochondrial GPAT showed an 89 and 95%, respectively, decrease in catalytic efficiency but no major change in substrate binding as indicated by the K(m) values for palmitoyl-CoA and glycerol 3-phosphate. These studies indicate importance of the conserved seven amino acid stretch for mitochondrial GPAT activity and the significance of Arg-318 for catalysis.  (+info)

Odorants presented to the rat nasal cavity increase cortical blood flow. (7/410)

Complaints about unpleasant environmental odorants, both outdoor and indoor, are increasingly being reported. The main complaints of health symptoms from environmental odorants are eye, nose and throat irritation, headache and drowsiness. Complaints may arise from the stimulation of olfactory receptors or trigeminal chemoreceptors. Stimulation of cerebrovascular nociceptors originating from a branch of the trigeminal nerve may be associated with an increase in cortical blood flow which is thought to be related to headache. Since odorants are reported to elicit headaches, the possibility that odorants may increase cortical blood flow was examined. Cortical blood flow was monitored in rats using a laser-Doppler flowmeter. The flowmeter probe was placed over the left frontal cortex while propionic acid, cyclohexanone, amyl acetate or butanol was delivered to the nasal cavity via an olfactometer. Cortical blood flow increased as the concentration increased for three of the odorants tested. The greatest increase in blood flow occurred to the presentation of propionic acid, followed by cyclohexanone and amyl acetate. There was no response to butanol. These data demonstrate that odorants can alter cerebrovascular blood flow, which may account, in part, for one of the health symptoms reported for odorants.  (+info)

3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46. (8/410)

A novel lactonohydrolase, an enzyme that catalyzes the hydrolysis of 3,4-dihydrocoumarin, was purified 375-fold to apparent homogeneity, with a 22.7% overall recovery, from Acinetobacter calcoaceticus F46, which was isolated as a fluorene-assimilating micro-organism. The molecular mass of the native enzyme, as estimated by high-performance gel-permeation chromatography, is 56 kDa, and the subunit molecular mass is 30 kDa. The enzyme specifically hydrolyzes 3,4-dihydrocoumarin, and the Km and Vmax for 3,4-dihydrocoumarin are 0.806 mM and 4760 U.mg-1, respectively. The N-terminal and internal amino acid sequences of the enzyme show high similarity to those of bacterial non-heme haloperoxidases. The enzyme exhibits brominating activity with monochlorodimedon in the presence of H2O2 and 3, 4-dihydrocoumarin or an organic acid, such as acetate and n-butyrate.  (+info)

11 pages, 2 figures, 2 tables, 7 schemes.-- PMID: 18549274 [PubMed].-- Printed version published Jul 18, 2008.-- Supporting information available: Preparation of substrate 22, including spectroscopic data of the synthetic intermediates and the final product. Procedures for the allylation and alkylation reactions, and spectroscopic data of phenyl ketones 20, 21, 27, butenolides 28-33 and 37-39, and cyclohexanones 46, 47, and 49. 1H and 13C NMR spectra for acetoxy acetal 24, allyl derivatives 18 and 19, phenyl ketones 20, 21, 26, and 27, butenolides 28-39, cyclohexanones 46-48 and 50-55, alkaloid analogues 56-61, and substrates 63-65 and 22.-- Available at: http://pubs.acs.org/doi/suppl/10.1021/jo800478a ...
Alfa Aesar™ 1,3-Cyclohexanedione, 97+%, may cont. up to 1% NaCl 100g Alfa Aesar™ 1,3-Cyclohexanedione, 97+%, may cont. up to 1% NaCl Cyanofluor...
Several reports have indicated that nuclear factor-κB (NF-κB) is constitutively activated in a variety of cancer cells including hepatoma cells and plays a key role in their growth and survival. Dehydroxymethylepoxyquinomicin (DHMEQ) derived from the structure of an antibiotic epoxyquinomicin C is a novel NF-κB inhibitor. In the present study, we evaluated the effect of DHMEQ on the NF-κB activity in human hepatoma cells, Huh-7, HepG2 and Hep3B, and the anti-tumor effect of DHMEQ on these cells in vitro and in vivo. DHMEQ inhibited the steady-state transcriptional activity of NF-κB in all hepatoma cells. DHMEQ blocked the constitutive DNA-binding activity and TNF-α-mediated nuclear translocation of NF-κB in Huh-7 cells. DHMEQ (5-20 µg/ml) dose-dependently reduced the viable cell number of all hepatoma cells. DHMEQ (20 µg/ml) induced apoptosis in all hepatoma cells, especially in Hep3B cells, and cell-cycle arrest in Huh-7 and HepG2 cells. These effects were accompanied by downregulation ...
Enantioselective Total Synthesis of the Polyketide Natural Product (-)-EI-1941-2: A Novel Interleukin-1β Converting Enzyme (ICE) Inhibitor.|span||/span| | Goverdhan Mehta; Subhrangsu Roy | download | BookSC. Download books for free. Find books
Structure Elucidation of EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941.|span||/span| | Fumito Koizumi; Yuichi Takahashi; Hiroki Ishiguro; Rieko Tanaka; Shizuo Ohtaki; Mayumi Yoshida; Satoshi Nakanishi; Shun-ichi Ikeda | download | BookSC. Download books for free. Find books
Factory Supply 99% 1,4-Cyclohexanedione mono CAS: 69225-59-8 Basic Info. Name:1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal) CAS: 69225-59-8 MF: C11H18O3 MW: 198.26 EINECS: 273-918-4 mp 45-50...
Other names: 3-Buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (E)-; «alpha»-Cyclocitrylideneacetone; (E)-«alpha»-Ionone; trans-«alpha»-Ionone; 3-Buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, trans; 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, (E)-; (3E)-4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-2-one; «alpha»-(E)-Ionone; trans-4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-2-one; 3-Buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (3E)-; Ionone; 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one («alpha»-ionone); 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-2-one; 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one ...
In this study, the synthesis of polypyrrole-b-vinyl aniline modified cyclohexanone formaldehyde resin (PPy-b-CFVAnR) block copolymers by a combination of condensation polymerization and chemical oxidative polymerization processes was examined. First, a cyclohexanone formaldehyde resin containing vinyl aniline units [4- vinyl aniline modified cyclohexanone formaldehyde resin (CFVAnR)] was prepared by a direct condensation reaction of 4-vinyl aniline and cyclohexanone with formaldehyde in an in situ modification reaction. CFVAnR and pyrrole (Py) were then used with a conventional method of in situ chemical oxidative polymerization. The reactions were carried out with heat-activated potassium persulfate salt in the presence of p-toluene sulfonic acid in a dimethyl sulfoxide-water binary solvent system; this led to the formation of desired block copolymers. The effects of the oxidant-monomer molar ratio, dopant existence, addition order of the reactants, and reaction temperature on the yield, ...
Methyl-substituted piperidines, oxanes, 1,3-dioxanes, and cyclohexanones were studied by photoelectron spectroscopy (pes) to determine the mechanism by which alkyl groups stabilize radical cations. Hyperconjugation was found to be the dominant mechanism, while inductive effects and charge-induced polarization were indicated to be less effective. N-Arylazacycloalkanes were studied by pes to correlate solution basicities with ionization potentials (IPs). Conformational analysis of these compounds indicated that aryl-substituted aziridines are coplanar (conjugating) in all cases studied, while ortho substituent(s) may cause rotation and loss of conjugation between the lone pair and the phenyl ring as the amine ring size is increased. N-Phenylpiperidine was indicated to be non-coplanar, despite the lack of ortho substituents. Pes studies of phencyclidine and a number of its analogs demonstrate that the amine lone pair IP changes predictably, depending on the nature and location of the substituent. The
CAS NO:78839-98-2; Chemical name:Benzene, [[5-(1,1-dimethylethyl)-2-methyl-1-cyclohexen-1-yl]thio]- ; physical and chemical property of 78839-98-2, Benzene, [[5-(1,1-dimethylethyl)-2-methyl-1-cyclohexen-1-yl]thio]- is provided by ChemNet.com
Looking for TCI AMERICAS 1,4-cyclohexanedione monoethyleneketal (29LU08)? Graingers got your back. Price:$50.25. Easy ordering & convenient delivery. Log-in or register for your pricing.
Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group Public Comment Summary July 2019 Résumé des commentaires du public sur lébauche dévaluation préalable du groupe des lactones et cétones macrocycliques, des ionones et de la cyclohexanone Juillet 2019
The report generally describes 4,4-(ethylenedioxy)cyclohexanone, examines its uses, production methods, patents. 4,4-(Ethylenedioxy)cyclohexanone market
Other names: 3-Buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)-; (E)-«beta»-Ionone; 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one; «beta»-E-Ionone; [E]-4-[2,6,6-trimethyl-1-cyclohexen-1-yl]-3-buten-2-one; 3-Buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E)-; «beta»-Ionone; «beta»-lonone; «beta»-Ionone isomer # 1; (E)-4-(2,6,6-Trimethylcyclohexen-1-yl)-3-buten-2-one; (3E)-4-(2,6,6-trimethylcyclohex-1-enyl)-3-buten-2-one (dihydro-«beta»-ionone ...
Insulin stimulated protein synthesis in L6 myoblasts but did not increase the labelling of DAG or the release of phosphocholine from phosphatidylcholine. The DAG lipase inhibitor, RHC 80267, more than doubled the amount of label appearing in DAG but did not stimulate protein synthesis. Even in the presence of the DAG lipase inhibitor insulin failed to have any effect on DAG labelling, and conversely RHC 80267 did not modify the insulin-induced increase in protein synthesis. These results suggest that endogenous DAG production is not involved in the stimulation of protein synthesis by insulin. However, exogenous diacylglycerols (1-oleoyl-2-acetyl glycerol and 1-stearoyl-2-arachidonoyl glycerol) both stimulated protein synthesis in L6 myoblasts. The efficacy of the former (arachidonatefree) DAG suggested that their action was by activation of protein kinase C rather than by arachidonate release and prostaglandin formation. Ibuprofen, an inhibitor of cyclo-oxygenase failed to block the effects of ...
2-(1-cyclohexen-1-yl)-2-methylpropanoic acid - chemical structural formula, chemical names, chemical properties, synthesis references
Benzene, 1,1-(3-cyclohexen-1-ylidene)bis- | C18H18 | CID 602040 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
s-[(3s)-3-methyl-1-cyclohexen-1-yl] ester c11h19nos (cas 255851 , 宽300x300高 , 显示比例:100% , 查看原图 , 图片来源 ...
102506-09-2 - SLSORSYCKMNPIJ-UHFFFAOYSA-N - (Cyclohexane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonicacid, sodium salt - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Many of these solvents become hazardous wastes when they can no longer be used in chemical manufacturing, or as ingredients in other products.2. Common names, the CAS number will always be the same regardless of the name used. 71-36-3. Butanol/n-Butyl Alcohol F003. U031. (I). 108-94-1. Cyclohexanone.. Chat Online ...
Cyclohexanone oxime is used primarily as a captive intermediate in the synthesis of caprolactam for the production of polycaprolactam (Nylon-6) fibers and plastics and also in a variety of industrial applications. Cyclohexanone oxime was selected for study because of the potential for human exposure and the interest in oximes as a chemical class. Toxicity studies of cyclohexanone oxime (approximately 99% pure) were carried out in male and female B6C3F1 mice; the compound was administered in drinking water for 2 weeks or 13 weeks. In addition, the genetic toxicity of cyclohexanone oxime was evaluated by determining mutagenicity in Salmonella typhimurium and induction of chromosomal aberrations in cultured Chinese hamster ovary cells in vitro, with and without S9 activation. The frequency of micronucleated normochromatic erythrocytes in the bone marrow and peripheral blood of mice from the 13-week study was also determined.. In the 2-week study, groups of five male and five female mice were given ...
are calculated. The calculated excess functions were correlated with reduced Redlich-Kister polynomial equation and results are analyzed in terms of structural molecular interactions between component molecules. Moreover, calibration of the partial molar volumes and partial isentropic compressibilitys of components shows strong interaction in 2-methyl cyclohexanone + 4-methoxy aniline than any other composites. In addition to the FTIR characteristic spectrum of all combinations at different concentrations gives the more promising features such as interaction behavior that helps our analysis to guide the interactions of individual bonding strength of the molecules ...
CYCLOHEXANONE ... - Brenntag product information page Brenntag is Beneluxs leading distributor and exporter of industrial chemicals and specialties, located in Belgium (Deerlijk, Antwerpen & Mouscron) and the Netherlands (Dordrecht, Loosdrecht, Zwijndrecht, Moerdijk, Rotterdam, Enschede).
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0097] A reaction tank of a reaction container equipped with a stirrer, a thermometer, a reflux condenser, a dripping apparatus, and a gas introduction tube was charged with 250 parts of cyclohexanone and stirring at 80° C. was performed for 1 hour while blowing in nitrogen gas. 100 parts of LA87 as the monomer (a1), 125 parts of 4HBA as the monomer (a2), 25 parts of MMA as the monomer (a3), 7.5 parts of AIBN, and 80.9 parts of cyclohexanone were charged into a dripping tank and then dripped into the reaction tank over a period of 2 hours while stirring the contents of the dripping tank. After the end of dripping, the dripping tank was washed with 34.7 parts of cyclohexanone and the washing liquid was then placed in the reaction tank. After letting react for another 2 hours, a solution in which 2.5 parts of AIBN were dissolved in 22.5 parts of cyclohexanone was divided into three equal portions that were added on three occasions 30 minutes apart. 1 hour after the third addition, the reaction ...
We,China Suppliers & China Manufacturers, provide our Products catalog2: United ACETONE, United BENZOIC ACID, United CYCLOHEXANONE
View Notes - Chem331_Exam_Review from CHEM 331l at South Carolina. Cyclohexanone 12) 2,4-DNP 13) Triphenylmethanol 14) 4-Ethyl phenol 15) 1-ethyl-4-n-propoxybenzene Experiment 5 : Oxidation of
China Cyclohexanone-Qingdao Hisea Chem Co., Ltd, Find details about China Cyclohexanone, Cyc from Cyclohexanone-Qingdao Hisea Chem Co., Ltd - Qingdao Hisea Chem Co., Ltd.
3-(Cyclopropylcarbonyloxy)-5-oxo-3-cyclohexene-1-carboxylic acid ethyl ester | C13H16O5 | CID 44312699 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Structure, properties, spectra, suppliers and links for: Ethyl (3R,4R,5S)-5-amino-4-[(1-|sup>11|/sup>C)ethanoylamino]-3-(3-pentanyloxy)-1-cyclohexene-1-c.
Learn more about Dimethyl-cis-4-cyclohexene-1,2-dicarboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
cyclohexane-1,3-dione 504-02-9 NMR spectrum, cyclohexane-1,3-dione H-NMR spectral analysis, cyclohexane-1,3-dione C-NMR spectral analysis ect.
No data is available on the substance itself. However, a reliable experimental study, conducted according to a recognized EC/DIN method and under GLP, is available on an analogue. Based on chemical similarity (both are alkene/ketone substituted trimethylcyclohexenes), and compared flash points, no significant difference is anticipated with the present dossier substance, so the read-across is considered justified for a key study. However, as the result is expressed as a limit value (analogue considered as a worst-case), it will not be retained as key value (no ,= sign allowed). This parameter is not relevant for classification, however the information is useful regarding process safety and potential additional fire hazard. No particular hazard is anticipated in normal conditions of storage. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Ethylbis(2-hydroxyethyl)oleylammonium ethyl sulphate 1-[(E)-pent-2-en-3-yl]naphthalene 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione 9H-Xanthen-9-one,3-[(1E)-2-[(1R,2R)-1,4- dimethyl-2-(1,4,5-trihydroxy-9-oxo-9Hxanthen- 3-yl)-3-cyclohexen-1-yl]ethenyl]-1,- 4,5-trihydroxy-,rel- Cobaltate(2-), (29H,31H-phthalocyanine-C,C-disulfonato(4-)-kappaN29,kappaN30,kappaN31,kappaN32)-, dihydrogen 2-[2-(4-aminophenyl)ethyl]-6-hydroxy-5-[4-(hydroxymethyl)-5-methyl-2-tert-butyl-phenyl]sulfanyl-2-phenyl-3H-pyran-4-one 8-Iso-19-noranthratestosterone 1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-2-isobutyl-5-(2-(6-methyl-3-pyridyl)ethyl)- N-[4-(4-acetylpiperazin-1-yl)phenyl]-3-chloro-benzamide Amosamine
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
ABSTRACT R1 R2 Mw RHC-1 -OCH3 -OCH3 396.42 RHC-2 -OCH3 -OH 368.37 RHC-3 -H -OH 308.32 RHC-4 -H -OCH3 336.39 RHC-5 -OH -OH 340.32 A selection of curcuminoids has been synthesized and complexed to HPβCD, MβCD and HPγCD ...
A series of octahydroacridine-1,8-diones have been synthesized in good yield via one-pot synthesis of corresponding tetrazolo[1,5-a]quinoline-4-carbaldehyde, 3-(4-fluorophenylamino)-5,5-dimethylcyclohex-2-enones and dimedone or cyclohexane-1,3-dione in acetic acid. All the synthesized compounds have been screened for antimicrobial and anti-tubercular activities ...
According to Regulation (EC) No. 1907/2006, Annex VIII, section 9.2.2.1, column 2, the study need not be conducted if the substance is highly insoluble in water or the substance is readily biodegradable. The water solubility of the test substance is 47 µg/L at 20 °C and is therefore classed as insoluble. Furthermore a Ready Biodegradability test shows 54.1% degradation after 28 days. Although this does not fulfill the minimum criteria set out by the OECD method, it does however indicate that the material achieved ,50 % within 30 days, highlighting its propensity for biodegradation. An inherent biodegradability test shows 80.5% degradation after 28 days, therefore it is considered that the material is inherently biodegradable and as such not persistent in environmentally significant conditions. Therefore given the poor solubility and propensity for biodegradation further studies are scientifically unjustified. ...
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TABLE-US-00001 TABLE 1 Peak and Relative Intensity Listing (degree 2θ, peaks with I/I1 value) Peak No. A I/I1 B I/I1 C I/I1 D I/I1 E I/I1 1 12.87 35 6.43 29 6.55 7 10.28 9 6.76 8 2 13.25 11 9.67 46 11.89 22 12.74 21 9.68 35 3 14.08 12 10.52 30 12.19 26 13.02 26 10.74 18 4 14.28 18 12.57 17 12.58 26 13.54 18 13.96 16 5 15.77 14 13.61 64 12.97 20 13.7 21 14.50 11 6 16.09 9 14.24 42 14.05 46 14.1 20 14.94 24 7 16.62 23 14.64 70 14.93 17 15.78 21 16.62 21 8 17.53 30 16.34 52 15.39 19 16.24 10 17.52 10 9 17.92 27 17.05 23 15.89 13 17.5 15 17.90 10 10 18.95 79 17.54 58 16.35 17 17.94 40 19.20 20 11 19.29 100 19.34 20 17.25 29 18.6 66 20.44 15 12 20.04 21 20.36 29 17.44 55 19.04 100 21.38 100 13 20.38 10 20.64 100 18.34 20 19.90 50 23.28 13 14 21.01 47 21.06 83 19.47 100 20.4 18 24.18 19 15 21.99 8 21.61 40 19.96 58 21.1 17 25.16 12 16 23.84 8 22.06 33 21.14 48 21.92 10 25.18 12 17 24.68 17 23.17 23 22.27 15 23.58 23 25.20 10 18 25.28 40 23.56 23 22.84 9 25.3 19 25.22 11 19 25.83 9 23.92 15 23.37 40 ...
Products CAS number 1,3-Cyclohexanedione 504-02-9 2,3-Butanedione 431-03-8 2,4-Pentadione 123-54-6
Buy (CAS 1027345-21-6), an intermediate in cell death regulator and apoptosis promoter production, from Santa Cruz Biotechnology. C15H19ClO, 250.76
Retinol ≥95.0% (HPLC), ~2700 U/mg; CAS Number: 68-26-8; EC Number: 200-683-7; Synonyms: Axerophthol,Vitamin A alcohol,Vitamin A1,Vitamin A,all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; find Sigma-Aldrich-17772 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
There are 9 thirteen-letter words containing A, H, 2N, O and X: ANDROSPHINXES ANTHOXANTHINS CYCLOHEXANONE ... PHYCOXANTHINS XANTHOPTERINE XANTHOPTERINS. Every word on this site is valid scrabble words. Build other lists, that start with or end with letters of your choice.
This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalyzing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones ...
The hydrogenation of a number of unsaturated compounds containing carbon-oxygen bonds has been studied. In most cases the reactions were performed at 30C and one atmosphere pressure of hydrogen, over Adams platinum oxide catalyst, in 50ml. of a solvent, usually containing some acid. It has been concluded from the results obtained that :- (1). Hydrogenolysis of the carbon-oxygen bond is always prevalent when acid or acidified solvents are used with a substrate having a centre of unsaturation close to the carbon-oxygen link. Thus under these conditions phenols, benzyl alcohols, allylic alcohols and cyclohexanones cleave readily. Removal of the centre of unsaturation from the vicinity of the carbon-oxygen bond renders it less liable to hydrogenolysis, as shown by the considerably smaller cleavage of ?-phenyl ethyl alcohol. The kinetics of the hydrogenolysis of phenols and benzyl alcohols show marked similarities with the kinetics of the hydrogenolysis of the corresponding phenyl and benzyl ...
TY - JOUR. T1 - Discovery of the first non-planar flavonoid that can strongly inhibit xanthine oxidase. T2 - Protoapigenone 1′-O-propargyl ether. AU - Hunyadi, Attila. AU - Martins, Ana. AU - Danko, Balazs. AU - Chuang, Da Wei. AU - Trouillas, Patrick. AU - Chang, Fang Rong. AU - Wu, Yang Chang. AU - Falkay, George. PY - 2013/11/27. Y1 - 2013/11/27. N2 - Xanthine oxidase (XO) is a key enzyme in purine metabolism with an important role in various pathologies. Several flavonoids have been reported for their capacity to inhibit this enzyme, and, for these compounds, the ability to adopt a planar 3D structure has been accepted as fundamental prerequisite for such activity. Here we report the in vitro investigation of a series of non-planar protoflavone derivatives as XO inhibitors, among which protoapigenone 1′-O-propargyl ether was found to be an efficient competitive inhibitor of the enzyme with an IC50 value of 3.61 μM, significantly (p ,0.001) stronger than the anti-gout drug allopurinol ...
Looking for online definition of Diacylglycerol lipase in the Medical Dictionary? Diacylglycerol lipase explanation free. What is Diacylglycerol lipase? Meaning of Diacylglycerol lipase medical term. What does Diacylglycerol lipase mean?
Process for the preparation of phenol and cyclohexanone which comprises: a. the synthesis of cyclohexylbenzene by the hydro-alkylation of benzene by contact with hydrogen or the alkylation of benzene with cyclohexene using Y zeolites; b. the selective aerobic oxidation of cyclohexylbenzene to the corresponding hydroperoxide catalyzed by N-hydroxy-derivatives in the presence of polar solvents; and c. the scission of the hydroperoxide of cyclohexylbenzene to phenol and cyclohexanone by homogeneous or heterogeneous acid catalysts; characterized in that the synthesis of cyclohexylbenzene takes place in the presence of a catalytic system comprising a Y zeolite and an inorganic ligand wherein the Y zeolite has a crystalline structure with openings consisting of 12 tetrahedra and the inorganic ligand is -alumina, and wherein said catalytic composition is characterized by a pore volume, obtained by adding the mesoporosity and macroporosity fractions, greater than or equal to 0.7 cm3/g, wherein at ...
endo-1,3-β-D-Glucanase (Trichoderma sp.) [ME-LAMSE] - High purity endo-1,3-beta-Glucanase (Trichoderma sp.) for use in research, biochemical enzyme assays and in vitrodiagnostic analysis. EC 3.2.1.39 From Trichoderma sp. Highly purified. In 3.2 M ammonium sulphate. Specific Activity: ~ 15 U/mg (40oC, pH 4.5, CM-Curdlan as substrate). Stable at 4oC for | 4 years.
Lanabecestat Molecular FormulaC26H28N4O Average mass412.527 Da Dispiro[cyclohexane-1,2-[2H]indene-1(3H),2-[2H]imidazol]-4-amine, 4-methoxy-5-methyl-6-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1R,4β)- (1r,1R,4R)-4-Methoxy-5-methyl-6-[5-(1-propin-1-yl)-3-pyridinyl]-3H-dispiro[cyclohexane-1,2-indene-1,2-imidazol]-4-amin (1r,1R,4R)-4-Methoxy-5-methyl-6-[5-(1-propyn-1-yl)-3-pyridinyl]-3H-dispiro[cyclohexane-1,2-indene-1,2-imidazol]-4-amine (lr,lR,4R)- 4-methoxy-5-methyl-6-[5-(prop-l-yn-l-yl)pyridin-3-yl]-3H- dispiro[cyclohexane-l,2-inden-l2-imidazole]-4-amine (lr,4r)-4-Methoxy-5-methyl-6-(5-prop-l-yn-l-ylpyridin-3-yl)-3H-dispiro[cyclohexane- l,2-indene-l,2-imidazol]- -amine CAS 1383982-64-6 AZD3293 Dispiro[cyclohexane-1,2-[1H]indene-1(3H),2-[2H]imidazol]-4-amine, 4-methoxy-5-methyl-6-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1R)- Lanabecestat LY3314814 UNII:X8SPJ492VF, AZ-12304146 Beta amyloid antagonist; Beta secretase 1 inhibitor; Beta secretase 2 inhibitor
3-(2-oxopropyl)-1-cyclohexen-1-yl acetate - chemical structural formula, chemical names, chemical properties, synthesis references
Page contains details about tris({[(9,10-dioxo-8a,9,10,10a-tetrahydroanthracen-2-yl)amino]methylidene})cyclohexane-1,3,5-trione nanowires . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Buy high quality 4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid Salt 359436-59-2 from toronto research chemicals Inc.
Fingerprint Dive into the research topics of A Single Step Low Cost Production of Cyclohexanone from Phenol Hydrogenation. Together they form a unique fingerprint. ...
472-64-0 - YJKGMUJSGUUUJU-UHFFFAOYSA-N - 2-Cyclohexene-1-acetaldehyde, 2,6,6-trimethyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Read Molecular structure investigation and biological evaluation of Michael adducts derived from dimedone, Research on Chemical Intermediates on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
TY - JOUR. T1 - Synthetic studies of cis-3a-aryloctahydroindole derivatives by copper- catalyzed cyclization of N-allyltrichloroacetamides. T2 - Facile construction of benzylic quaternary carbons by carbon-carbon bond-forming reactions. AU - Iwamatsu, Sho Ichi. AU - Matsubara, Kouki. AU - Nagashima, Hideo. PY - 1999/12/24. Y1 - 1999/12/24. N2 - Cyclization of N-(2-aryl-2-cyclohexen-1-yl)trichloroacetamides by a copper catalyst was investigated. It is crucially important for successful cyclization under mild conditions that alkoxycarbonyl groups are introduced to the nitrogen atom of the N-allyltrichloroacetamides as well as that CuCl- (bipyridine) is used as the catalyst. Three compounds, N-(2-phenyl-2- cyclohexen-1-yl)-, N-[2-(3,4-dimethoxyphenyl)-2-cyclohexen-l-yl]-, and N-[2- (3,4-methylenedioxyphenyl)-2-cyclohexen-1-yl]trichloroacetamides, where the Cbz or MeO2C- group was attached to the nitrogen atom, were instantly converted to the corresponding trichlorinated cis-3a-aryloctahydroindol-2- ...
Isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane, compounds found in cruciferous vegetable, are highly effective in inducing cell cycle arrest and apoptosis in a variety of cancer cells and animal models. Although some studies indicate that ITC-induced reactive oxygen species (ROS) generation may underlie apoptosis induction, our recent studies show that covalent binding to target proteins may be an important event triggering apoptosis. In this study, we report that BITC and PEITC significantly inhibit proteasome activity in a variety of cell types. Further studies show that ITCs inhibit both the 26S and 20S proteasomes, presumably through direct binding, and that this inhibition is unrelated to either ROS generation or ITC-induced protein aggregation. The potency of ITC-induced proteasome inhibition correlates with the rapid accumulation of p53 (tumor suppressor) and IκB nuclear factor-kappaB (nuclear factor-kappaB inhibitor). ...
Identifying the sulfenylation state of stressed cells is emerging as a strategic approach for the detection of key reactive oxygen species signaling proteins. Here, we optimized an in vivo trapping method for cysteine sulfenic acids in hydrogen peroxide (H2O2) stressed plant cells using a dimedone based DYn-2 probe. We demonstrated that DYn-2 specifically detects sulfenylation events in an H2O2 dose- and time-dependent way. With mass spectrometry, we identified 226 sulfenylated proteins after H2O2 treatment of Arabidopsis cells, residing in the cytoplasm (123); plastid (68); mitochondria (14); nucleus (10); endoplasmic reticulum, Golgi and plasma membrane (7) and peroxisomes (4). Of these, 123 sulfenylated proteins have never been reported before to undergo cysteine oxidative post-translational modifications in plants. All in all, with this DYn-2 approach, we have identified new sulfenylated proteins, and gave a first glance on the locations of the sulfenomes of Arabidopsis thaliana.. ...
Cyclohexanone is an aliphatic cyclic ketone. Cyclohexanone derivatives have potent pharmacological activity in the treatment of a broad spectrum of medical conditions (Puetz et al., 2003). The cyclohexanone moiety constitutes an important structural feature in several anti-inflammatory, analgesic, local anesthetic and antihistaminic drugs (Rajveer et al., 2010). As part of our studies in this area (Fatima et al., 2013; Hema et al., 2006), we have undertaken a single-crystal structure determination of the title compound.. In the title compound, Fig. 1, the cyclohexene ring (C9-C14) adopts an envelope conformation with atom C13 as the flap: puckering parameters (Cremer & Pople, 1975) are Q = 0.464 (3) Å, θ = 52.3 (4) °, and ϕ = 232.2 (4) °. Its mean plane makes a dihedral angle of 7.20 (12)° with the benzene ring (C1-C6).. In the crystal, hydrogen bonded chains running along the a-axis direction are generated by connecting neighbouring molecules via C-H···O hydrogen bonds (Table 1 and ...
The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: ##STR00001## wherein G represents a galloyl group; theasinensins represented by the formula: ##STR00002## wherein R.sub.1 represents G or H, and R.sub.2 represents G; and theaflavins represented by the formula: ##STR00003## wherein R.sub.1 and R.sub.2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
R-(+)-Pulegone was administered orally to rats and the urinary metabolites were investigated. Six metabolites were isolated and purified using column and thin layer chromatographic techniques. Metabolites were identified by i.r., n.m.r. and mass spectral analyses.The neutral metabolites isolated from urine of rats treated with pulegone (I) were: pulegol (II), 2-hydroxy-2(1-hydroxy-1-methylethyl)-5-methylcyclohexanone (III), 3,6-dimethyl-7a-hydroxy-5,6,7,7a-tetrahydro-2(4H)-benzofuranone (V) and menthofuran (VII). Metabolites II and III were also excreted in conjugated form.Acidic metabolites isolated from urine of rats treated with pulegone (I) were: 5-methyl-2(1-methyl-1-carboxyethylidene)cyclohexanone (IV) and 5-methyl-5-hydroxy-2(1hydroxy--carboxyethyl)cyclohexanone (VI). ...
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A total synthesis of the complex, bent aromatic ring-containing marine alkaloid haouamine A is achieved through a route in which every step (with the exception of the final deprotection) is performed on a gram-scale. This is accomplished through the development of a method for the dehydrogenation of cyclohexenones that allows for point-to-planar chirality transfer. This strategy makes it possible to program the desired atropisomeric outcome from a simple chiral cyclohexenone. By synthesizing atrop-haouamine A, this work has firmly established that natural haouamine exists as a single, nonequilibrating atropisomer. Finally, biological investigations demonstrate that the bent aromatic ring of this natural product is critical for anticancer activity against PC3 cells ...
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A phosphate-free automatic dishwashing cleaning composition comprising a crystal growth inhibitor system comprising cyclohexane-1,2,3,4,5,6-hexacarboxylic acid (CHHCA) and cyclopentane-1,2,3,4-tetracarboxylic acid (CPTCA).
On the basis of medical and environmental data collected at the Water Well Drillers (SIC-4619) in Western Tennessee, the use of polyvinyl-chloride (PVC) cement is not found to constitute a health hazard under existing conditions of use. Environmental samples show only low levels of tetrahydrofuran (109999) and no detectable levels of cyclohexanone (108941). Responses to medical questionnaires indi
SWISS-MODEL Repository entry for P9WK11 (MEND_MYCTU), 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase. Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
AP-1 and NF-κB inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the ...
Cyclohexylbenzene is a precursor to both phenol and cyclohexanone. Hydration of cyclohexene gives cyclohexanol, which can be ... Musser, Michael T. (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... dehydrogenated to give cyclohexanone, a precursor to caprolactam. The oxidative cleavage of cyclohexene gives adipic acid. ...
The cyclohexanone-cyclohexanol mixture, called "KA oil", is a raw material for adipic acid and caprolactam, precursors to nylon ... Several million kilograms of cyclohexanone and cyclohexanol are produced annually. It is used as a solvent in some brands of ... Michael Tuttle Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley ... Although rather unreactive, cyclohexane undergoes catalytic oxidation to produce cyclohexanone and cyclohexanol. ...
216 "ICSC 0425 - CYCLOHEXANONE". www.inchem.org. Retrieved 18 March 2018. "MSDS Cyclopentadiene". ox.ac.uk. Retrieved 18 March ...
This rearrangement first creates the vinyl oxazolidine from attack on the cyclohexanone by the aminobutenol, which then ... Upon formation, Overman showed that cyclohexanones can be used for the carbonyl component in pyrrolidine synthesis. This ... highlighting the thermodynamic favorability of releasing cyclohexanone from the double bonded carbonyl, as it creates ... reaction proceeded with various forms of cyclohexanones. When an acyclic ketone was substituted, the reaction proceeded with ...
Hydrogenation gives the cyclohexanone derivative. Epoxidation with basic hydrogen peroxide affords the oxide. Isophorone is ...
... for the oxidation of cyclohexanone; an alcohol dehydrogenase for oxidation of the "double-smart cosubstrate" 1,6-hexanediol; ...
For example, consider the compound methyl cyclohexanone-4-carboxylate, where lithium aluminium hydride reduction will produce 4 ... ISBN 978-0-85404-182-4. R. A. Daignault, E. L. Eliel (1973). "2-Cyclohexyloxyethanol (involves acetalisation of cyclohexanone ...
The plant was re-built but cyclohexanone was now produced by hydrogenation of phenol (Nypro proposed to produce the hydrogen ... causing a small percentage of the cyclohexane to oxidise and produce cyclohexanone, some cyclohexanol also being produced. Each ... The caprolactam was produced from cyclohexanone. This was originally produced by hydrogenation of phenol, but in 1972 ... including one in which cyclohexane was oxidised to cyclohexanone and cyclohexanol). Historically good process safety ...
It is a metal-mediated rearrangement of enol ether pyrans to cyclohexanones. Typically, this reaction is catalyzed by mercury ... used the Ferrier conditions to synthesise complex conjugated cyclohexanones in 1998. Ferrier, RJ (1979). "Unsaturated ...
Via the Hock rearrangement, cyclohexylbenzene hydroperoxide cleaves to give phenol and cyclohexanone. Cyclohexanone is an ...
Romero E, Castellanos JR, Mattevi A, Fraaije MW (2016) Characterization and crystal structure of a robust cyclohexanone ... alcohol to lactone cascade with alcohol dehydrogenase-cyclohexanone monooxygenase fusions. Appl Microbiol Biotechnol. 101, 7557 ... "Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase". Angewandte Chemie International Edition. 55 ( ... alcohol to lactone cascade with alcohol dehydrogenase-cyclohexanone monooxygenase fusions". Applied Microbiology and ...
The oil contains 80% to 92% of cyclohexanone pulegone. Pulegone, the molecule in highest concentration in the pennyroyal plant ...
Another application is the rearrangement of cyclohexanone oxime to caprolactam. Many alkylamines are prepared by amination of ...
Fürst, Maximilian J. L. J.; Boonstra, Marjon; Bandstra, Selle; Fraaije, Marco W. (2019). "Stabilization of cyclohexanone ... Sheng, Dawei; Ballou, David P.; Massey, Vincent (1 September 2001). "Mechanistic Studies of Cyclohexanone Monooxygenase: ...
NOCl and cyclohexane react photochemically to give cyclohexanone oxime hydrochloride. This process exploits the tendency of ...
... has been synthesized from cyclohexanone and from salicylic acid. In the former route, the additional carbon is ...
It can be prepared by oxidation of cyclohexanone by selenium dioxide. The enol is about 1 kcal/mol more stable than the diketo ...
It can be produced by a Wittig reaction or a reaction with a Tebbe's reagent from cyclohexanone. It can also be synthesized as ... ISBN 978-1-118-00538-5. Now, when cyclohexanone is added to the solution in which the [Tebbe] reagent has been generated, ... ISBN 978-0-470-04610-4. I this way, cyclohexanone is transformed into methylenecyclohexene and benzaldehyde into stryene. ...
Other cyclic ketones: Cyclopropanone Cyclopentanone Cyclohexanone CRC Handbook of Chemistry and Physics. 90. Boca Raton, ...
"A synthesis of vitamin a from cyclohexanone", J. Chem. Soc.: 1094-1111, doi:10.1039/JR9520001094. Paquette, Leo A. and ...
... such as the Henbest Catalyst for transfer hydrogenation of cyclohexanones. Thomas R. B. Mitchell (2001). "Iridium(IV) Chloride ...
Cyclohexanol from Cyclohexanone". Organic Syntheses. 69: 96. doi:10.15227/orgsyn.069.0096. M. Caporali, L. Gonsalvi, F. ...
4-dihydroxy-cyclohexanone 1,1,3,4-Cyclohexanetetrol (4 isomers); hydrate of 3,4-dihydroxy-cyclohexanone Possible isomers with ...
Another important factor in the scents is the emission of cyclohexanone and toluene. Though the chemicals are naturally toxic, ...
In the first step, phenylhydrazine is condensed with cyclohexanone to the corresponding imine. The second step is a ...
Similarly, reacting DEAD with ethanol and cyclohexanol abstracts hydrogen producing acetaldehyde and cyclohexanone. Those ...
2-methylamino-Cyclohexanone as a New Ketamine Derivative". Synthetic Communications. 44 (14): 2021-2028. doi:10.1080/ ...
Other cyclic ketones: cyclobutanone, cyclopentanone, cyclohexanone Other cyclopropane derivatives: cyclopropene, cyclopropenone ...
The archetypical reaction is that of the silyl enol ether of cyclohexanone with benzaldehyde. At room temperature it produces a ...
... is also produced by the reaction of cyclohexanone with sodium ethoxide and nitromethane. The resulting sodium ... Cycloheptanone is also prepared by ring expansion of cyclohexanone with diazomethane as the methylene source. Cycloheptanone ...
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations ...
Cyclohexanone. CAS No: 108-94-1. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Cyclohexanone. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
NIOSH [2020]. NIOSH skin notation profile: cyclohexanone. By Hudson NL. Cincinnati, OH: U.S. Department of Health and Human ... This Skin Notation Profile provides the SK assignments and supportive data for cyclohexanone. In particular, this document ... NIOSH Skin Notation Profile Cyclohexanone 2021-103 pdf icon[PDF - 412 KB] ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Cyclohexanone Sigma-Aldrich Co., Cyclohexanone. Retrieved on 2017-11-20. "Cyclohexanone". Immediately Dangerous to Life or ... The other half of the cyclohexanone supply is converted to cyclohexanone oxime. In the presence of sulfuric acid catalyst, the ... Over time, samples of cyclohexanone assume a yellow color. Cyclohexanone is slightly soluble in water and miscible with common ... Like cyclohexanol, cyclohexanone is not carcinogenic and is moderately toxic, with a TLV of 25 ppm for the vapor. It is an ...
Cyclohexanone oxime can be prepared from the condensation reaction between cyclohexanone and hydroxylamine: C5H10CO + H2NOH → ... Cyclohexanone oxime is an organic compound containing the functional group oxime. This colorless solid is an important ... It can also be hydrolyzed with acetic acid to give back cyclohexanone. J. C. Eck and C. S. Marvel "ε-Benzoylaminocaproic Acid" ... This method is advantageous as cyclohexane is much cheaper than cyclohexanone. The most famous and commercially important ...
... cyclohexanone 0.98; CAS Number: 52190-35-9; Linear Formula: CH3SC6H9(=O); find related products, papers, technical documents, ... ne is a 2-substituted cyclohexanone. The proportion of axial and equatorial conformation has been measured in chloroform by the ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
An OECD guideline study (404) showed after an exposure period of 3 hours slight to moderate erythema as well as slight edema. After an exposure period of 1 h our slight to marked erythema and after 4 hours slight to moderate erythema were observed. In an EpiDerm test in vitro a corrosive potential of the test substance was seen (BASF, 2003). An in vitro eye irritation test (HET-CAM) showed serious eye damage (BASF, 2006). This was in concordance with an older BASF in vivo study (1966), where severe irritating eye effects were found. ...
The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... Kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a. Bag type copper-alloy catalyst. ...
Cyclohexanone is used as an industrial solvent and paint remover. It acts as a precursor to nylon 6,6 and nylon 6 and ... Zhang, J.; Dong, C.; Du, C.; Luo, G. Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System. ... Patil, R. D.; Sasson, Y. Selective transfer hydrogenation of phenol to cyclohexanone on supported palladium catalyst using ... cyclohexanone oxime, which gives caprolactam on rearrangement. Further, it is used as a chemical reaction medium, adhesives, ...
SBA-15 Cyclohexanol Dehydrogenation Cyclohexanone Electronic supplementary material. The online version of this article ( https ... Copper oxide modified SBA-15 for the selective vapour phase dehydrogenation of cyclohexanol to cyclohexanone. ...
A) Stepwise sequence for Pd-mediated dehydrogenation of cyclohexanone. (B) Catalytic mechanism whereby cyclohexanone ... Dehydrogenation of cyclohexanones catalyzed by palladium(II) trifluoroacetate. J. Mol. Catal. 15, 373 (1982). doi:10.1016/0304- ... Reaction conditions are as follows: cyclohexanone (0.5 mmol), Pd(TFA)2 (0.025 mmol), 2-(N,N-dimethylamino)pyridine (0.05 mmol ... 3). Varying the position of the methyl substituent on the cyclohexanone had little effect on the outcome of the reaction; the ...
4-trans-4-propylcyclohexyl cyclohexanone, 4-4-propylcyclohexyl cyclohexanone, 4-propyldicyclohexylanone, 4-trans-4-n- ... 4-trans-4-propylcyclohexyl cyclohexanone, 4-4-propylcyclohexyl cyclohexanone, 4-propyldicyclohexylanone, 4-trans-4-n- ... propylcyclohexyl-cyclohexanone, 4-4-propylcyclohexyl cyclohexan-1-one, 4-trans-4-propylcyclohexyl cyclohexanone, 4-propyl-1,1 ... propylcyclohexyl-cyclohexanone, 4-4-propylcyclohexyl cyclohexan-1-one, 4-trans-4-propylcyclohexyl cyclohexanone, 4-propyl-1,1 ...
Cyclohexanone monooxygenase. A. 548. Rhodococcus sp. HI-31. Mutation(s): 0 Gene Names: chnB, chnB1. EC: 1.14.13.22. ... Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis.. Yachnin, B.J., ... Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation. *DOI: 10.2210/pdb4RG3/ ... Here, we report two crystal structures of cyclohexanone monooxygenase (CHMO) with its product, ε-caprolactone, bound: the CHMO( ...
Product name: CYCLOHEXANONE Batch Number 20161008 Manu.date 2016.10.08 standaard Index Specification Result Chrominance ≤15 10 ...
The Global Cyclohexanone Peroxide Market Report provides a basic overview of the Global Cyclohexanone Peroxide including ... Global Cyclohexanone Peroxide Forecast 2017-2022. *Global Cyclohexanone Peroxide Capacity, Production, Revenue Forecast 2017- ... Global Cyclohexanone Peroxide Production Forecast by Type 2017-2022. *Global Cyclohexanone Peroxide Consumption Forecast by ... Global Cyclohexanone Peroxide Market report is a professional and in-depth study on the current state of the Global ...
Cyclohexanone 2,4-dinitrophenylhydrazone is a useful standard for elemental analysis. Also used as a pharmaceutical ... Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4- ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Cyclohexanone Chemicals, Cyclohexene Chemicals, Heptanesulfonic Acid Sodium Salt Anhydrous and Diethylamine Chemicals offered ... Offering you a complete choice of products which include Cyclohexane Chemicals, Cyclohexanone Chemicals, Cyclohexene Chemicals ... we are able to supply an extensive array of high-quality Cyclohexanone Chemicals to our customers which is an organic compound ... cyclohexanone and as fuel for camp stoves. Features:. *Well-packed ...
... cyclohexanone suppliers, manufacturers, wholesalers, cyclohexanone sellers, traders, exporters and distributors from China and ... cyclohexanone Manufacturers Directory ☆ 3 million global importers and exporters ☆ ... Looking for cyclohexanone ?. You have come to the right place. This page is your cyclohexanone one-stop source for the ... Cyclohexanone Solvent. Application of Cyclohexanone It is the raw material for the production of caprolactam and adipic acid; ...
CYCLOHEXANONE. CAS NO:12262-58-7; MF:C6H10O. White to colorless solid.. JSL Chemical Corporation More>>. ...
... cyclohexanone, examines its uses, production methods, patents. 4,4-(Ethylenedioxy)cyclohexanone market ... Cyclohexanone Markets in China US$ 4,000.00 Apr, 2017 · 193 pages Cyclohexanone Market Research US$ 2,770.00 Apr, 2009 · 124 ... 4,4-(ethylenedioxy)cyclohexanone prices in other regions. 7. 4,4-(ETHYLENEDIOXY)CYCLOHEXANONE END-USE SECTOR 7.1. 4,4-( ... 4,4-(ethylenedioxy)cyclohexanone market forecast. 6. 4,4-(ETHYLENEDIOXY)CYCLOHEXANONE MARKET PRICES. 6.1. 4,4-(ethylenedioxy) ...
... cyclohexanone] or BDMC33 exhibited improved anti-inflammatory activity by inhibiting nitric oxide synthesis in activated ... Our preliminary screening had shown that the curcumin derivative [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] or BDMC33 ... A Curcumin Derivative, 2,6-Bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) Attenuates Prostaglandin E2 Synthesis via ... "A Curcumin Derivative, 2,6-Bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) Attenuates Prostaglandin E2 Synthesis via ...
Ionones and Cyclohexanone Group Public Comment Summary July 2019 Résumé des commentaires du public sur lébauche dévaluation ... préalable du groupe des lactones et cétones macrocycliques, des ionones et de la cyclohexanone Juillet 2019 ... Comments on the draft assessment for the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group to be addressed as ... Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group Public Comment Summary Official Title: Macrocyclic Lactones ...
... selectivity to cyclohexanone using hydrogen peroxide as an oxidant and WO3 as a catalyst. The effect of the IL as a solvent is ... cyclohexanone. using hydrogen peroxide. as an oxidant and WO3 as a catalyst. . The effect of the IL as a solvent. is discussed ... cyclohexanone. in the ionic liquid. 1-octyl-3-methylimidazolium chloride. L. Chen, T. Zhou, L. Chen, Y. Ye, Z. Qi, H. Freund ... Selective oxidation of cyclohexanol to cyclohexanone in the ionic liquid1-octyl-3-methylimidazolium chloride ...
where to buy 14176-50-2(Cyclohexanone,2-(ethylamino)-2-(2-thienyl)-, hydrochloride (1:1)).Also offer free database of 14176-50- ... 2(Cyclohexanone,2-(ethylamino)-2-(2-thienyl)-, hydrochloride (1:1)) including MSDS sheet(poisoning, toxicity, hazards and ... cyclohexanone hydrochloride (1:1); CN-54521-2; Cyclohexanone, 2-(ethylamino)-2-(2-thienyl)-, hydrochloride; cyclohexano ... Cyclohexanone,2-(ethylamino)-2-(2-thienyl)-, hydrochloride (1:1) 1) Quick Response Within 12 hours; 2) Quality Guarantee: All ...
... cyclohexanone, a product for proteomics research, from Santa Cruz. MF: C15H13F3O2, MW: 282.2577 ... 2-[(E)-Benzylidene]-6-(2,2,2-trifluoroacetyl)cyclohexanone *bvseo_sdk, java_sdk, bvseo-3.2.0 ... 2-[(E)-Benzylidene]-6-(2,2,2-trifluoroacetyl)cyclohexanone MF: C15H13F3O2. MW: 282.26 *HEM. ...
Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Message Subject (Your Name) has forwarded a page to you ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ...
4-N-acetyl-amino-cyclohexanone Molecular formula:C8H13NO2 Molecular weight:155.19 CAS:27514-08-5 Properties:Light yellow or off ... to white powder; MP:114~118ºC; lose on drying:less than1.0%; heavy - 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5 Details. ... 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5. Home / Chemicals / Organic Chemical Materials / 4-N-acetyl-amino-cyclohexanone, ... Detailed 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5 Description:. Name: 4-N-acetyl-amino-cyclohexanone. Molecular formula: ...

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