Cyclohexane ring substituted by one or more ketones in any position.

Characterisation of the conformational and quaternary structure-dependent heparin-binding region of bovine seminal plasma protein PDC-109. (1/410)

PDC-109, the major heparin-binding protein of bull seminal plasma, binds to sperm choline lipids at ejaculation and modulates capacitation mediated by heparin. Affinity chromatography on heparin-Sepharose showed that polydisperse, but not monomeric, PDC-109 displayed heparin-binding capability. We sought to characterise the surface topology of the quaternary structure-dependent heparin-binding region of PDC-109 by comparing the arginine- and lysine-selective chemical modification patterns of the free and the heparin-bound protein. A combination of reversed-phase peptide mapping of endoproteinase Lys-C-digested PDC-109 derivatives and mass spectrometry was employed to identify modified and heparin-protected residues. PDC-109 contains two tandemly arranged fibronectin type II domains (a, Cys24-Cys61; b, Cys69-Cys109). The results show that six basic residues (Lys34, Arg57, Lys59, Arg64, Lys68, and Arg104) were shielded from reaction with acetic anhydride and 1,2-cyclohexanedione in heparin-bound PDC-109 oligomers. In the 1H-NMR solution structures of single fibronectin type II domains, residues topologically equivalent to PDC-109 Arg57 (Arg104) and Lys59 lay around beta-strand D on the same face of the domain. In full-length PDC-109, Arg64 and Lys68 are both located in the intervening polypeptide between domains a and b. Our data suggest possible quaternary structure arrangements of PDC-109 molecules to form a heparin-binding oligomer.  (+info)

Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. (2/410)

BACKGROUND: Oxalate, a common constituent of kidney stones, is cytotoxic for renal epithelial cells. Although the exact mechanism of oxalate-induced cell death remains unclear, studies in various cell types, including renal epithelial cells, have implicated phospholipase A2 (PLA2) as a prominent mediator of cellular injury. Thus, these studies examined the role of PLA2 in the cytotoxic effects of oxalate. METHODS: The release of [3H]-arachidonic acid (AA) or [3H]-oleic acid (OA) from prelabeled Madin-Darby canine kidney (MDCK) cells was measured as an index for PLA2 activity. The cell viability was assessed by the exclusion of ethidium homodimer-1. RESULTS: Oxalate exposure (175 to 550 microM free) increased the release of [3H]-AA in MDCK cells but had no effect on the release of [3H]-OA. Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2. The [3H]-AA release could be demonstrated within 15 minutes after exposure to oxalate, which is considerably earlier than the observed changes in cell viability. Furthermore, AACOCF3 significantly reduced oxalate toxicity in MDCK cells. CONCLUSIONS: Oxalate increases AA release from MDCK cells by a process involving cPLA2. In addition, based on the evidence obtained using a selective inhibitor of this isoform, it would appear that the activity of this enzyme is responsible, at least in part, for the cytotoxic effects of oxalate. The finding that oxalate can trigger a known lipid-signaling pathway may provide new insight into the initial events in the pathogenesis of nephrolithiasis.  (+info)

Purification and characterization of monovalent cation-activated levodione reductase from Corynebacterium aquaticum M-13. (3/410)

(6R)-2,2,6-Trimethyl-1,4-cyclohexanedione (levodione) reductase was isolated from a cell extract of the soil isolate Corynebacterium aquaticum M-13. This enzyme catalyzed regio- and stereoselective reduction of levodione to (4R,6R)-4-hydroxy-2,2, 6-trimethylcyclohexanone (actinol). The relative molecular mass of the enzyme was estimated to be 142,000 Da by high-performance gel permeation chromatography and 36,000 Da by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme required NAD(+) or NADH as a cofactor, and it catalyzed reversible oxidoreduction between actinol and levodione. The enzyme was highly activated by monovalent cations, such as K(+), Na(+), and NH(4)(+). The NH(2)-terminal and partial amino acid sequences of the enzyme showed that it belongs to the short-chain alcohol dehydrogenase/reductase family. This is the first report of levodione reductase.  (+info)

Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases. (4/410)

The genes encoding flavin mononucleotide-containing oxidoreductases, designated xenobiotic reductases, from Pseudomonas putida II-B and P. fluorescens I-C that removed nitrite from nitroglycerin (NG) by cleavage of the nitroester bond were cloned, sequenced, and characterized. The P. putida gene, xenA, encodes a 39,702-Da monomeric, NAD(P)H-dependent flavoprotein that removes either the terminal or central nitro groups from NG and that reduces 2-cyclohexen-1-one but did not readily reduce 2,4,6-trinitrotoluene (TNT). The P. fluorescens gene, xenB, encodes a 37,441-Da monomeric, NAD(P)H-dependent flavoprotein that exhibits fivefold regioselectivity for removal of the central nitro group from NG and that transforms TNT but did not readily react with 2-cyclohexen-1-one. Heterologous expression of xenA and xenB was demonstrated in Escherichia coli DH5alpha. The transcription initiation sites of both xenA and xenB were identified by primer extension analysis. BLAST analyses conducted with the P. putida xenA and the P. fluorescens xenB sequences demonstrated that these genes are similar to several other bacterial genes that encode broad-specificity flavoprotein reductases. The prokaryotic flavoprotein reductases described herein likely shared a common ancestor with old yellow enzyme of yeast, a broad-specificity enzyme which may serve a detoxification role in antioxidant defense systems.  (+info)

N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. (5/410)

E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays a role in maintaining the normal phenotype of epithelial cells. Decreased expression of E-cadherin has been correlated with increased invasiveness of breast cancer. In other systems, inappropriate expression of a nonepithelial cadherin, such as N-cadherin, by an epithelial cell has been shown to downregulate E-cadherin expression and to contribute to a scattered phenotype. In this study, we explored the possibility that expression of nonepithelial cadherins may be correlated with increased motility and invasion in breast cancer cells. We show that N-cadherin promotes motility and invasion; that decreased expression of E-cadherin does not necessarily correlate with motility or invasion; that N-cadherin expression correlates both with invasion and motility, and likely plays a direct role in promoting motility; that forced expression of E-cadherin in invasive, N-cadherin-positive cells does not reduce their motility or invasive capacity; that forced expression of N-cadherin in noninvasive, E-cadherin-positive cells produces an invasive cell, even though these cells continue to express high levels of E-cadherin; that N-cadherin-dependent motility may be mediated by FGF receptor signaling; and that cadherin-11 promotes epithelial cell motility in a manner similar to N-cadherin.  (+info)

A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis. (6/410)

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and committed step in glycerolipid biosynthesis. We previously cloned the cDNA sequence to murine mitochondrial GPAT (Yet, S-F., Lee, S., Hahm, Y. T., and Sul, H.S. (1993) Biochemistry 32, 9486-9491). We expressed the protein in insect cells which was targeted to mitochondria, purified, and reconstituted mitochondrial GPAT activity using phospholipids (Yet, S.-F., Moon, Y., and Sul, H. S. (1995) Biochemistry 34, 7303-7310). Deletion of the seven amino acids from mitochondrial GPAT, (312)IFLEGTR(318), which is highly conserved among acyltransferases in glycerolipid biosynthesis, drastically reduced mitochondrial GPAT activity. Treatment of mitochondrial GPAT with arginine-modifying agents, phenylglyoxal and cyclohexanedione, inactivated the enzyme. Two highly conserved arginine residues, Arg-318, in the seven amino stretch, and Arg-278, were identified. Substitution of Arg-318 with either alanine, histidine, or lysine reduced the mitochondrial GPAT activity by over 90%. On the other hand, although substitution of Arg-278 with alanine and histidine decreased mitochondrial GPAT activity by 90%, replacement with lysine reduced activity by only 25%. A substitution of the nonconserved Arg-279 with either alanine, histidine, or lysine did not alter mitochondrial GPAT activity. Moreover, R278K mitochondrial GPAT still showed sensitivity to arginine-modifying agents, as in the case of wild-type mitochondrial GPAT. These results suggest that Arg-318 may be critical for mitochondrial GPAT activity, whereas Arg-278 can be replaced by a basic amino acid. Examination of the other conserved residues in the seven amino acid stretch revealed that Phe-313 and Glu-315 are also important, but conservative substitutions can partially maintain activity; substitution with alanine reduced activity by 83 and 72%, respectively, whereas substituting Phe-313 with tyrosine and Glu-315 with glutamine had even lesser effect. In addition, there was no change in fatty acyl-CoA selectivity. Kinetic analysis of the R318K and R318A mitochondrial GPAT showed an 89 and 95%, respectively, decrease in catalytic efficiency but no major change in substrate binding as indicated by the K(m) values for palmitoyl-CoA and glycerol 3-phosphate. These studies indicate importance of the conserved seven amino acid stretch for mitochondrial GPAT activity and the significance of Arg-318 for catalysis.  (+info)

Odorants presented to the rat nasal cavity increase cortical blood flow. (7/410)

Complaints about unpleasant environmental odorants, both outdoor and indoor, are increasingly being reported. The main complaints of health symptoms from environmental odorants are eye, nose and throat irritation, headache and drowsiness. Complaints may arise from the stimulation of olfactory receptors or trigeminal chemoreceptors. Stimulation of cerebrovascular nociceptors originating from a branch of the trigeminal nerve may be associated with an increase in cortical blood flow which is thought to be related to headache. Since odorants are reported to elicit headaches, the possibility that odorants may increase cortical blood flow was examined. Cortical blood flow was monitored in rats using a laser-Doppler flowmeter. The flowmeter probe was placed over the left frontal cortex while propionic acid, cyclohexanone, amyl acetate or butanol was delivered to the nasal cavity via an olfactometer. Cortical blood flow increased as the concentration increased for three of the odorants tested. The greatest increase in blood flow occurred to the presentation of propionic acid, followed by cyclohexanone and amyl acetate. There was no response to butanol. These data demonstrate that odorants can alter cerebrovascular blood flow, which may account, in part, for one of the health symptoms reported for odorants.  (+info)

3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46. (8/410)

A novel lactonohydrolase, an enzyme that catalyzes the hydrolysis of 3,4-dihydrocoumarin, was purified 375-fold to apparent homogeneity, with a 22.7% overall recovery, from Acinetobacter calcoaceticus F46, which was isolated as a fluorene-assimilating micro-organism. The molecular mass of the native enzyme, as estimated by high-performance gel-permeation chromatography, is 56 kDa, and the subunit molecular mass is 30 kDa. The enzyme specifically hydrolyzes 3,4-dihydrocoumarin, and the Km and Vmax for 3,4-dihydrocoumarin are 0.806 mM and 4760 U.mg-1, respectively. The N-terminal and internal amino acid sequences of the enzyme show high similarity to those of bacterial non-heme haloperoxidases. The enzyme exhibits brominating activity with monochlorodimedon in the presence of H2O2 and 3, 4-dihydrocoumarin or an organic acid, such as acetate and n-butyrate.  (+info)

"Cyclohexanone". Sigma-Aldrich. Sigma-Aldrich Co., Cyclohexanone. Retrieved on 2022-03-17. Cyclohexanone: toxicity for animals ... The other half of the cyclohexanone supply is converted to cyclohexanone oxime. In the presence of sulfuric acid catalyst, the ... "ICSC 0425 - CYCLOHEXANONE". inchem.org. Retrieved 2022-08-24. "CDC - NIOSH Pocket Guide to Chemical Hazards - Cyclohexanone". ... Over time, samples of cyclohexanone assume a pale yellow color. Cyclohexanone is slightly soluble in water and miscible with ...
... can be prepared from the condensation reaction between cyclohexanone and hydroxylamine: C5H10CO + H2NOH → ... Cyclohexanone oxime is an organic compound containing the functional group oxime. This colorless solid is an important ... It can also be hydrolyzed with acetic acid to give back cyclohexanone. J. C. Eck and C. S. Marvel "ε-Benzoylaminocaproic Acid" ... This method is advantageous as cyclohexane is much cheaper than cyclohexanone. The most famous and commercially important ...
In enzymology, a cyclohexanone dehydrogenase (EC 1.3.99.14) is an enzyme that catalyzes a chemical reaction cyclohexanone + ... The systematic name of this enzyme class is cyclohexanone:acceptor 2-oxidoreductase. This enzyme is also called cyclohexanone:( ... the two substrates of this enzyme are cyclohexanone and acceptor, whereas its two products are cyclohex-2-enone and reduced ...
... (EC 1.14.13.22, cyclohexanone 1,2-monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH: ... Ottolina G, Bianchi S, Belloni B, Carrea G, Danieli B (1999). "First asymmetric oxidation of tertiary amines by cyclohexanone ... doi:10.1016/s0040-4039(02)00029-1. Cyclohexanone+monooxygenase at the US National Library of Medicine Medical Subject Headings ... Stewart, J.D. (1998). "Cyclohexanone monooxygenase: a useful reagent for asymmetric Baeyer-Villiger reactions". Curr. Org. Chem ...
... is specifically listed as an illegal drug in Latvia. It is also covered by drug ... 4-Dimethylamino-4-(p-tolyl)cyclohexanone (sometimes known as dimetamine) is a narcotic analgesic with an arylcyclohexylamine ...
It is one of the peroxides derived from the reaction of cyclohexanone and hydrogen peroxide. Upon treatment with acid and ... Cyclohexanone Peroxides". The Journal of Organic Chemistry. 35 (9): 3059-3062. doi:10.1021/jo00834a042. McCullough, Kevin J.; ...
Cyclohexylbenzene is a precursor to both phenol and cyclohexanone. Hydration of cyclohexene gives cyclohexanol, which can be ... Musser, Michael T. (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ... dehydrogenated to give cyclohexanone, a precursor to caprolactam. The oxidative cleavage of cyclohexene gives adipic acid. ...
Additionally, the reactivity of two series of ketones are in the orders Cl3CCOCH3 > CH3COCH3 > C6H5COCH3 and cyclohexanone > ... For instance, the reaction of cyclopentanone with diazomethane forms cyclohexanone (shown below). The Büchner ring expansion ... Giraitis, Albert; Jesse Bullock (May 1937). "Reactions of Cyclohexanone with Diazoethane". Journal of the American Chemical ...
The cyclohexanone-cyclohexanol mixture, called "KA oil", is a raw material for adipic acid and caprolactam, precursors to nylon ... Several million kilograms of cyclohexanone and cyclohexanol are produced annually. It is used as a solvent in some brands of ... Michael Tuttle Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley ... Although rather unreactive, cyclohexane undergoes catalytic oxidation to produce cyclohexanone and cyclohexanol. ...
For example, the cobalt catalyzed oxidation of cyclohexane to cyclohexanone: C6H12 + O2 → (CH2)5CO + H2O Drying oils, as found ... "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a08_ ...
Tamio Hayashi, Makoto Takahashi, Yoshiaki Takaya, and Masamichi Ogasawara (2004). "(R)-3-phenyl-cyclohexanone". Organic ... 3-phenyl-cyclohexanone from cyclohexenone, phenylboronic acid, a rhodium acac catalyst and the chiral ligand BINAP.[2] In ... cyclohexanone. Conjugated carbonyls react with hydrogen cyanide to 1,4-keto-nitriles. See hydrocyanation of unsaturated ...
216 "ICSC 0425 - CYCLOHEXANONE". www.inchem.org. Retrieved 18 March 2018. "MSDS Cyclopentadiene". ox.ac.uk. Retrieved 18 March ...
R. B. Woodward, I. J. Pachter, and M. L. Scheinbaum (1974). "2,2-(Trimethylenedithio)cyclohexanone". Organic Syntheses. 54: 39 ...
ISBN 0-8247-7764-6 R. B. Woodward, I. J. Pachter, and M. L. Scheinbaum (1974). "2,2- (Trimethylenedithio)cyclohexanone". ...
This rearrangement first creates the vinyl oxazolidine from attack on the cyclohexanone by the aminobutenol, which then ... Upon formation, Overman showed that cyclohexanones can be used for the carbonyl component in pyrrolidine synthesis. This ... highlighting the thermodynamic favorability of releasing cyclohexanone from the double bonded carbonyl, as it creates ... reaction proceeded with various forms of cyclohexanones. When an acyclic ketone was substituted, the reaction proceeded with ...
Hydrogenation gives the cyclohexanone derivative. Epoxidation with basic hydrogen peroxide affords the oxide. Isophorone is ...
... for the oxidation of cyclohexanone; an alcohol dehydrogenase for oxidation of the "double-smart cosubstrate" 1,6-hexanediol; ...
For example, consider the compound methyl cyclohexanone-4-carboxylate, where lithium aluminium hydride reduction will produce 4 ... R. A. Daignault, E. L. Eliel (1973). "2-Cyclohexyloxyethanol (involves acetalisation of cyclohexanone)". Organic Syntheses.; ...
The plant was re-built but cyclohexanone was now produced by hydrogenation of phenol (Nypro proposed to produce the hydrogen ... causing a small percentage of the cyclohexane to oxidise and produce cyclohexanone, some cyclohexanol also being produced. Each ... The caprolactam was produced from cyclohexanone. This was originally produced by hydrogenation of phenol, but in 1972 ... including one in which cyclohexane was oxidised to cyclohexanone and cyclohexanol). Historically good process safety ...
It is a metal-mediated rearrangement of enol ether pyrans to cyclohexanones. Typically, this reaction is catalyzed by mercury ... used the Ferrier conditions to synthesise complex conjugated cyclohexanones in 1998. Ferrier, RJ (1979). "Unsaturated ...
Camphor and cyclohexanone are used for minty flavoring. Benzaldehyde is used for cherry or almond flavoring. Cinnamaldehyde is ... cyclohexanone, benzaldehyde, cresol, butyraldehyde, and isoamyl acetate. Sugars are frequently used in e-liquids to provide a ...
Via the Hock rearrangement, cyclohexylbenzene hydroperoxide cleaves to give phenol and cyclohexanone. Cyclohexanone is an ...
Via the Hock rearrangement, cyclohexylbenzene hydroperoxide cleaves to give phenol and cyclohexanone. Cyclohexanone is an ...
Via the Hock rearrangement, cyclohexylbenzene hydroperoxide cleaves to give phenol and cyclohexanone. Cyclohexanone is an ... Partial hydrogenation of phenol gives cyclohexanone, a precursor to nylon. Nonionic detergents are produced by alkylation of ...
Romero E, Castellanos JR, Mattevi A, Fraaije MW (2016) Characterization and crystal structure of a robust cyclohexanone ... alcohol to lactone cascade with alcohol dehydrogenase-cyclohexanone monooxygenase fusions. Appl Microbiol Biotechnol. 101, 7557 ... "Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase". Angewandte Chemie International Edition. 55 ( ... alcohol to lactone cascade with alcohol dehydrogenase-cyclohexanone monooxygenase fusions". Applied Microbiology and ...
"Reactions of oxetane with imine salts derived from cyclohexanone". The Journal of Organic Chemistry. 40 (20): 2963-2965. doi: ...
The oil contains 80% to 92% of cyclohexanone pulegone. Pulegone, the molecule in highest concentration in the pennyroyal plant ...
Another application is the rearrangement of cyclohexanone oxime to caprolactam. Many alkylamines are prepared by amination of ...
It is prepared by condensation of cyclohexanone to give cyclohexenylcyclohexanone. The latter undergoes dehydrogenation to give ...
Fürst, Maximilian J. L. J.; Boonstra, Marjon; Bandstra, Selle; Fraaije, Marco W. (2019). "Stabilization of cyclohexanone ... Sheng, Dawei; Ballou, David P.; Massey, Vincent (1 September 2001). "Mechanistic Studies of Cyclohexanone Monooxygenase: ...
Testing Status of Cyclohexanone oxime M88037. Testing Status of Cyclohexanone oxime M88037. CASRN: 100-64-1. Related: 2- ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Drug Metab Dispos. 1991 Nov-Dec;19(6):1101-7.Pubmed ... Toxicity Studies of Cyclohexanone Oxime (CASRN 100-64-1) Administered by Drinking Water to B6C3F1 Mice ... Toxicity Studies of Cyclohexanone Oxime (CASRN 100-64-1) Administered by Drinking Water to B6C3F1 Mice ...
World Health Organization; International Programme on Chemical Safety; International Labour Organization; United Nations Environment Programme (‎World Health OrganizationWorld Health Organization, 1995)‎ ...
Comprehensive supplier list for Cyclohexanone,2-(4-methoxybenzoyl)-6-[4-(2-methoxyphenyl)-1-piperazinyl]-, hydrochloride(1:1), ... CYCLOHEXANONE,2-(HYDROXYMETHYLENE)-6-(ISOPROPYL)- (2 suppliers). 412016-93-4. CYCLOHEXANONE,2-(HYDROXYMETHYLENE)-6-METHYL-,(E)- ... CYCLOHEXANONE,2-(HYDROXYDIBENZYL)- (2 suppliers). 33831-21-9. CYCLOHEXANONE,2-(HYDROXYMETHYL)-3-(METHOXYMETHOXY)-2-METHYL-,(2R, ... Synonyms: 2-(6-Chrysenyl)cyclohexanone, AC1L4CEE, 2-chrysen-6-ylcyclohexan-1-one, Cyclohexanone, 2-(6-chrysenyl)- Molecular ...
Cyclohexanone. Molecular Formula CHO. Average mass 98.143 Da. Monoisotopic mass 98.073166 Da. ChemSpider ID 7679. ... cyclohexanone nist. Cyclohexanone , C6H10O , ChemSpider. Cyclohexanone. Molecular Formula CHO. Average mass 98.143 Da. ... Cyclohexanone - Wikipedia. Cyclohexanone is the organic compound with the formula (CH2)5CO. The molecule consists of six-carbon ... cyclohexanone, 108-94-1 - The Good Scents Company. Cyclohexanone is formed from the hydrocarbons cyclohexane and 1-, 2-, and 3- ...
Text; Format: print Publication details: Geneva : World Health Organization, 1995Availability: Items available for loan: WHO HQ (1)Call number: HQ SERIAL. Not available: WHO HQ: Withdrawn (1). ...
3-Month Evaluation of the Toxicity (C88047) of Cyclohexanone Oxime (100-64-1) in B6C3F1 Mice Exposed via Dosed Water Pathology ... TOX-50 Toxicity Studies of Cyclohexanone Oxime in B6C3F1Mice (Drinking Water Studies) (CASRN 100-64-1). *[Abstract] ... Genetic Toxicity Evaluation of Cyclohexanone Oxime in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 152023 Summary ... Cyclohexanone oxime (100-64-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Dehydrogenation of Cyclohexanol to Cyclohexanone Over Nitrogen-doped Graphene supported Cu catalyst ... Dehydrogenation of Cyclohexanol to Cyclohexanone Over Nitrogen-doped Graphene supported Cu catalyst Download ...
In addition, the calculated Koc-values of the single components, namely cyclohexanol and cyclohexanone, adsorption to solid ...
Cyclohexanone and a series of different alkylated cyclohexanone derivatives were used as diluents. Two sources of ionizing ... a visible increase of stability was observed for systems containing 2-Me-cyclohexanone or 2,6-di-Me-cyclohexanone diluents. ... 2] In this study, radiation stability of CyMe4--BTBP or CyMe4--BTPhen was examined in systems with series of cyclohexanone- ... Radiation Stability of CyMe,sub,4,/sub,-BTBP and CyMe,sub,4,/sub,-BTPhen in their Solutions in Cyclohexanone-based Diluents ...
A menthone that is cyclohexanone substituted by a methyl and an isopropyl group at positions 5 and 2 respectively (the 2R,5S- ... Cyclohexanone, 5-me. thyl-2-(1-methyleth. yl)-, (2R,5S)- [ACD/Index Name] ... Cyclohexanone, 5-me. thyl-2-(1-methyleth. yl)-, (2S,5R)- [ACD/Index Name] ... A menthone that is cyclohexanone substituted by a methyl and an isopropyl group at positions 5 and 2 respectively (the 2,stereo ...
Cyclohexanone. 100 µg/mL. CAS #: 108-94-1 * Dibromochloromethane. 100 µg/mL. CAS #: 124-48-1 ...
Ketamine (2-(2-chlorophenyl)-2- (methylamino)cyclohexanone). *. 15 Fentanyls, their salts, derivatives, and analogues and salts ...
Cyclohexanones / therapeutic use* Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Cyclohexanones / therapeutic use* Actions. * Search in PubMed * Search in MeSH * Add to Search ...
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... and cyclohexanone was low, based on NIOSH RELs and OSHA PELs. However, using ACGIH TLVs, additive exposure for the screen ... and cyclohexanone. Full-shift monitoring results indicated that air contaminant concentrations for the screen printer, screen ...
MeSH Terms: Air Pollutants/analysis*; Air Pollution*; Aptitude Tests; Child; Child, Preschool; Cognition*; Cyclohexanones/ ...
A solution of 147 g. (1.50 moles) of cyclohexanone, 157 g. (1.80 moles) of morpholine (Note 1), and 1.5 g. of p-toluenesulfonic ... This is a general method of preparing enamines from a secondary aliphatic amine and cyclohexanone or cyclopentanone. Acylation ... 6 Alkylation of enamines of cyclohexanones by alkyl halides5,7 or electrophilic olefins,8 followed by hydrolysis, is a good ...
... cyclohexanone; cyclopentanone; butyl acetate; propylene glycol monomethyl ether acetate; pentakis(dime thylamino)tantalum(V) ... cyclohexanone; cyclopentanone; butyl acetate; propylene glycol monomethyl ether acetate; pentakis(dimethylamino)tantalum(V) ...
Autoignition points for fuels and chemicals like butane, coke, hydrogen, petroleum and more.
Cyclohexanone. 2,4-D. DDT. 4,4-DDD. 4,4-DDE. 4,4-DDT. Dibenzo(a,h)anthracene. ...
Cyclohexanone: E. Decane: E. Dibromoethane: E. Dichlorobenzene: E. Dichlorodifluoromethane: G. Dichloroethane: E. ...
Isomerization and Fragmentation of Cyclohexanone in a Heated Micro-Reactor. J.P. Porterfield, T.L. Nguyen, J.H. Baraban, G.T. ...
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima.. Collu F; Bonsignore L; Casu M; Floris C; ...
Cyclohexanone 1L : 11.8 euros. Diacetone alcohol 100ml : 3.7 €. Diethyl ether 1L : :10.4 €. Cyclohexane 2.5L : 17.10 €. Toluene ... Cyclohexanone 1L : 11.8 euros. Diacetone alcohol 100ml : 3.7 €. Diethyl ether 1L : :10.4 €. Cyclohexane 2.5L : 17.10 €. Toluene ...
  • During the site visit NIOSH met with management and employee representatives, observed work activities, assessed PPE use, evaluated ventilation for the screen printing and spray painting operations, and measured exposures to toluene, n-hexane, isopropyl alcohol, acetone, and cyclohexanone. (cdc.gov)
  • Additionally, exposure to the combined mixture (additive exposure) of toluene, n-hexane, isopropyl alcohol, acetone, and cyclohexanone was low, based on NIOSH RELs and OSHA PELs. (cdc.gov)
  • 1974. The toxicology of cyclotrimethylenetrinitramine (RDX) and cyclotetramethylenetetranitramine (HMX) solutions in dimethylsulfoxide (DMSO), cyclohexanone, and acetone. (cdc.gov)
  • In addition, the calculated Koc-values of the single components, namely cyclohexanol and cyclohexanone, adsorption to solid soil phase (e.g. clay) is not expected( range of Koc: 8.11 -15.15). (europa.eu)
  • Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated (±)-2-( o -Chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. (nih.gov)
  • Cyclohexanone and a series of different alkylated cyclohexanone derivatives were used as diluents. (cvut.cz)
  • 9. Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. (nih.gov)
  • 18. Cyclohexanone derivatives with cytotoxicity from the fungus Penicillium commune. (nih.gov)
  • 2022118 Cyclohexanone was condensed with cyanoacetic acid to give cyclohexylidene cyanoacetic acid, and then eliminated and decarboxylated to give cyclohexene acetonitrile. (martinicosmetics.pl)
  • In case of CyMe 4 --BTBP in absence of the acid, a visible increase of stability was observed for systems containing 2-Me-cyclohexanone or 2,6-di-Me-cyclohexanone diluents. (cvut.cz)
  • From this point, the system containing 3-Me-cyclohexanone seems better due to uniform stability in presence/absence of the acid. (cvut.cz)
  • An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Cyclohexanone oxime (100-64-1). (nih.gov)
  • 3-Month Evaluation of the Toxicity (C88047) of Cyclohexanone Oxime (100-64-1) in B6C3F1 Mice Exposed via Dosed Water. (nih.gov)
  • In vivo, no induction of micronuclei was noted in erythrocytes of mice treated with cyclohexanone oxime either for 13 weeks in drinking water or for 3 days by intraperitoneal injection. (nih.gov)
  • Cyclohexanone oxime was selected for study because of the potential for human exposure and the interest in oximes as a chemical class. (nih.gov)
  • Citation: Parmar D, Burka LT. Metabolism and disposition of cyclohexanone oxime in male F-344 rats. (nih.gov)
  • Results of search for 'su:{Cyclohexanones. (who.int)
  • results of mutagenicity testing of cyclohexanone oxime were negative in strains TA97, TA98, and TA100, with and without S9. (nih.gov)
  • This Skin Notation Profile provides the SK assignments and supportive data for cyclohexanone. (cdc.gov)
  • 2] In this study, radiation stability of CyMe 4 --BTBP or CyMe 4 --BTPhen was examined in systems with series of cyclohexanone-based diluents. (cvut.cz)
  • In addition, the genetic toxicity of cyclohexanone oxime was evaluated by determining mutagenicity in Salmonella typhimurium and induction of chromosomal aberrations in cultured Chinese hamster ovary cells in vitro, with and without S9 activation. (nih.gov)
  • Genetic Toxicity Evaluation of Cyclohexanone Oxime in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • Genetic Toxicity Evaluation of Cyclohexanone in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • In addition, the genetic toxicity of cyclohexanone oxime was evaluated by determining mutagenicity in Salmonella typhimurium and induction of chromosomal aberrations in cultured Chinese hamster ovary cells in vitro, with and without S9 activation. (nih.gov)
  • 1974. The toxicology of cyclotrimethylenetrinitramine (RDX) and cyclotetramethylenetetranitramine (HMX) solutions in dimethylsulfoxide (DMSO), cyclohexanone, and acetone. (cdc.gov)
  • An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Cyclohexanone (108-94-1). (nih.gov)
  • results of mutagenicity testing of cyclohexanone oxime were negative in strains TA97, TA98, and TA100, with and without S9. (nih.gov)
  • Cyclohexanone, diethyl ketone , ethyl butyl ketone , methyl n-amyl ketone , methyl n-butyl ketone , methyl ethyl ketone , methyl isopropyl ketone , and methyl propyl ketone were tested. (cdc.gov)
  • Cyclohexanone oxime is used primarily as a captive intermediate in the synthesis of caprolactam for the production of polycaprolactam (Nylon-6) fibers and plastics and also in a variety of industrial applications. (nih.gov)
  • Results of search for 'su:{Cyclohexanones. (who.int)