Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Norisoprenoids: Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.Calendula: A plant genus of the family ASTERACEAE. Members contain CAROTENOIDS, essential oils (OILS, VOLATILE), flavonoids, mucilage, SAPONINS, and STEROLS. The plants are used both topically and internally. The common name of Marigold is also used for TAGETES.Macrocyclic Compounds: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.Bryostatins: A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.Macrolides: A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.Oximes: Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.Rats, Inbred F344Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.Vanadium Compounds: Inorganic compounds that contain vanadium as an integral part of the molecule.Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)Science: The study of natural phenomena by observation, measurement, and experimentation.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Ontario: A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.South CarolinaPhenol: An antiseptic and disinfectant aromatic alcohol.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Cyclohexanes: Six-carbon alicyclic hydrocarbons.Protein HydrolysatesZinc Sulfate: A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Gibberellins: A class of plant growth hormone isolated from cultures of Gibberella fujikuroi, a fungus causing Bakanae disease in rice. There are many different members of the family as well as mixtures of multiple members; all are diterpenoid acids based on the gibberellane skeleton.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Astringents: Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.Cottonseed Oil: Oil obtained from the seeds of Gossypium herbaceum L., the cotton plant. It is used in dietary products such as oleomargarine and many cooking oils. Cottonseed oil is commonly used in soaps and cosmetics.BelgiumHemorrhagic Disorders: Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).Nocardia: A genus of gram-positive, aerobic bacteria whose species are widely distributed and are abundant in soil. Some strains are pathogenic opportunists for humans and animals.Fungicides, Industrial: Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.Turkeys: Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)TurkeyZineb: An agricultural fungicide of the dithiocarbamate class. It has relatively low toxicity and there is little evidence of human injury from exposure.Maneb: Manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat.Fertilizers: Substances or mixtures that are added to the soil to supply nutrients or to make available nutrients already present in the soil, in order to increase plant growth and productivity.

Characterisation of the conformational and quaternary structure-dependent heparin-binding region of bovine seminal plasma protein PDC-109. (1/410)

PDC-109, the major heparin-binding protein of bull seminal plasma, binds to sperm choline lipids at ejaculation and modulates capacitation mediated by heparin. Affinity chromatography on heparin-Sepharose showed that polydisperse, but not monomeric, PDC-109 displayed heparin-binding capability. We sought to characterise the surface topology of the quaternary structure-dependent heparin-binding region of PDC-109 by comparing the arginine- and lysine-selective chemical modification patterns of the free and the heparin-bound protein. A combination of reversed-phase peptide mapping of endoproteinase Lys-C-digested PDC-109 derivatives and mass spectrometry was employed to identify modified and heparin-protected residues. PDC-109 contains two tandemly arranged fibronectin type II domains (a, Cys24-Cys61; b, Cys69-Cys109). The results show that six basic residues (Lys34, Arg57, Lys59, Arg64, Lys68, and Arg104) were shielded from reaction with acetic anhydride and 1,2-cyclohexanedione in heparin-bound PDC-109 oligomers. In the 1H-NMR solution structures of single fibronectin type II domains, residues topologically equivalent to PDC-109 Arg57 (Arg104) and Lys59 lay around beta-strand D on the same face of the domain. In full-length PDC-109, Arg64 and Lys68 are both located in the intervening polypeptide between domains a and b. Our data suggest possible quaternary structure arrangements of PDC-109 molecules to form a heparin-binding oligomer.  (+info)

Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. (2/410)

BACKGROUND: Oxalate, a common constituent of kidney stones, is cytotoxic for renal epithelial cells. Although the exact mechanism of oxalate-induced cell death remains unclear, studies in various cell types, including renal epithelial cells, have implicated phospholipase A2 (PLA2) as a prominent mediator of cellular injury. Thus, these studies examined the role of PLA2 in the cytotoxic effects of oxalate. METHODS: The release of [3H]-arachidonic acid (AA) or [3H]-oleic acid (OA) from prelabeled Madin-Darby canine kidney (MDCK) cells was measured as an index for PLA2 activity. The cell viability was assessed by the exclusion of ethidium homodimer-1. RESULTS: Oxalate exposure (175 to 550 microM free) increased the release of [3H]-AA in MDCK cells but had no effect on the release of [3H]-OA. Oxalate-induced [3H]-AA release was abolished by arachidonyl trifluoromethyl ketone (AACOCF3), a selective inhibitor of cytosolic PLA2 (cPLA2), but was not affected by selective inhibitors of secretory PLA2 and calcium-independent PLA2. The [3H]-AA release could be demonstrated within 15 minutes after exposure to oxalate, which is considerably earlier than the observed changes in cell viability. Furthermore, AACOCF3 significantly reduced oxalate toxicity in MDCK cells. CONCLUSIONS: Oxalate increases AA release from MDCK cells by a process involving cPLA2. In addition, based on the evidence obtained using a selective inhibitor of this isoform, it would appear that the activity of this enzyme is responsible, at least in part, for the cytotoxic effects of oxalate. The finding that oxalate can trigger a known lipid-signaling pathway may provide new insight into the initial events in the pathogenesis of nephrolithiasis.  (+info)

Purification and characterization of monovalent cation-activated levodione reductase from Corynebacterium aquaticum M-13. (3/410)

(6R)-2,2,6-Trimethyl-1,4-cyclohexanedione (levodione) reductase was isolated from a cell extract of the soil isolate Corynebacterium aquaticum M-13. This enzyme catalyzed regio- and stereoselective reduction of levodione to (4R,6R)-4-hydroxy-2,2, 6-trimethylcyclohexanone (actinol). The relative molecular mass of the enzyme was estimated to be 142,000 Da by high-performance gel permeation chromatography and 36,000 Da by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme required NAD(+) or NADH as a cofactor, and it catalyzed reversible oxidoreduction between actinol and levodione. The enzyme was highly activated by monovalent cations, such as K(+), Na(+), and NH(4)(+). The NH(2)-terminal and partial amino acid sequences of the enzyme showed that it belongs to the short-chain alcohol dehydrogenase/reductase family. This is the first report of levodione reductase.  (+info)

Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases. (4/410)

The genes encoding flavin mononucleotide-containing oxidoreductases, designated xenobiotic reductases, from Pseudomonas putida II-B and P. fluorescens I-C that removed nitrite from nitroglycerin (NG) by cleavage of the nitroester bond were cloned, sequenced, and characterized. The P. putida gene, xenA, encodes a 39,702-Da monomeric, NAD(P)H-dependent flavoprotein that removes either the terminal or central nitro groups from NG and that reduces 2-cyclohexen-1-one but did not readily reduce 2,4,6-trinitrotoluene (TNT). The P. fluorescens gene, xenB, encodes a 37,441-Da monomeric, NAD(P)H-dependent flavoprotein that exhibits fivefold regioselectivity for removal of the central nitro group from NG and that transforms TNT but did not readily react with 2-cyclohexen-1-one. Heterologous expression of xenA and xenB was demonstrated in Escherichia coli DH5alpha. The transcription initiation sites of both xenA and xenB were identified by primer extension analysis. BLAST analyses conducted with the P. putida xenA and the P. fluorescens xenB sequences demonstrated that these genes are similar to several other bacterial genes that encode broad-specificity flavoprotein reductases. The prokaryotic flavoprotein reductases described herein likely shared a common ancestor with old yellow enzyme of yeast, a broad-specificity enzyme which may serve a detoxification role in antioxidant defense systems.  (+info)

N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. (5/410)

E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays a role in maintaining the normal phenotype of epithelial cells. Decreased expression of E-cadherin has been correlated with increased invasiveness of breast cancer. In other systems, inappropriate expression of a nonepithelial cadherin, such as N-cadherin, by an epithelial cell has been shown to downregulate E-cadherin expression and to contribute to a scattered phenotype. In this study, we explored the possibility that expression of nonepithelial cadherins may be correlated with increased motility and invasion in breast cancer cells. We show that N-cadherin promotes motility and invasion; that decreased expression of E-cadherin does not necessarily correlate with motility or invasion; that N-cadherin expression correlates both with invasion and motility, and likely plays a direct role in promoting motility; that forced expression of E-cadherin in invasive, N-cadherin-positive cells does not reduce their motility or invasive capacity; that forced expression of N-cadherin in noninvasive, E-cadherin-positive cells produces an invasive cell, even though these cells continue to express high levels of E-cadherin; that N-cadherin-dependent motility may be mediated by FGF receptor signaling; and that cadherin-11 promotes epithelial cell motility in a manner similar to N-cadherin.  (+info)

A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis. (6/410)

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and committed step in glycerolipid biosynthesis. We previously cloned the cDNA sequence to murine mitochondrial GPAT (Yet, S-F., Lee, S., Hahm, Y. T., and Sul, H.S. (1993) Biochemistry 32, 9486-9491). We expressed the protein in insect cells which was targeted to mitochondria, purified, and reconstituted mitochondrial GPAT activity using phospholipids (Yet, S.-F., Moon, Y., and Sul, H. S. (1995) Biochemistry 34, 7303-7310). Deletion of the seven amino acids from mitochondrial GPAT, (312)IFLEGTR(318), which is highly conserved among acyltransferases in glycerolipid biosynthesis, drastically reduced mitochondrial GPAT activity. Treatment of mitochondrial GPAT with arginine-modifying agents, phenylglyoxal and cyclohexanedione, inactivated the enzyme. Two highly conserved arginine residues, Arg-318, in the seven amino stretch, and Arg-278, were identified. Substitution of Arg-318 with either alanine, histidine, or lysine reduced the mitochondrial GPAT activity by over 90%. On the other hand, although substitution of Arg-278 with alanine and histidine decreased mitochondrial GPAT activity by 90%, replacement with lysine reduced activity by only 25%. A substitution of the nonconserved Arg-279 with either alanine, histidine, or lysine did not alter mitochondrial GPAT activity. Moreover, R278K mitochondrial GPAT still showed sensitivity to arginine-modifying agents, as in the case of wild-type mitochondrial GPAT. These results suggest that Arg-318 may be critical for mitochondrial GPAT activity, whereas Arg-278 can be replaced by a basic amino acid. Examination of the other conserved residues in the seven amino acid stretch revealed that Phe-313 and Glu-315 are also important, but conservative substitutions can partially maintain activity; substitution with alanine reduced activity by 83 and 72%, respectively, whereas substituting Phe-313 with tyrosine and Glu-315 with glutamine had even lesser effect. In addition, there was no change in fatty acyl-CoA selectivity. Kinetic analysis of the R318K and R318A mitochondrial GPAT showed an 89 and 95%, respectively, decrease in catalytic efficiency but no major change in substrate binding as indicated by the K(m) values for palmitoyl-CoA and glycerol 3-phosphate. These studies indicate importance of the conserved seven amino acid stretch for mitochondrial GPAT activity and the significance of Arg-318 for catalysis.  (+info)

Odorants presented to the rat nasal cavity increase cortical blood flow. (7/410)

Complaints about unpleasant environmental odorants, both outdoor and indoor, are increasingly being reported. The main complaints of health symptoms from environmental odorants are eye, nose and throat irritation, headache and drowsiness. Complaints may arise from the stimulation of olfactory receptors or trigeminal chemoreceptors. Stimulation of cerebrovascular nociceptors originating from a branch of the trigeminal nerve may be associated with an increase in cortical blood flow which is thought to be related to headache. Since odorants are reported to elicit headaches, the possibility that odorants may increase cortical blood flow was examined. Cortical blood flow was monitored in rats using a laser-Doppler flowmeter. The flowmeter probe was placed over the left frontal cortex while propionic acid, cyclohexanone, amyl acetate or butanol was delivered to the nasal cavity via an olfactometer. Cortical blood flow increased as the concentration increased for three of the odorants tested. The greatest increase in blood flow occurred to the presentation of propionic acid, followed by cyclohexanone and amyl acetate. There was no response to butanol. These data demonstrate that odorants can alter cerebrovascular blood flow, which may account, in part, for one of the health symptoms reported for odorants.  (+info)

3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46. (8/410)

A novel lactonohydrolase, an enzyme that catalyzes the hydrolysis of 3,4-dihydrocoumarin, was purified 375-fold to apparent homogeneity, with a 22.7% overall recovery, from Acinetobacter calcoaceticus F46, which was isolated as a fluorene-assimilating micro-organism. The molecular mass of the native enzyme, as estimated by high-performance gel-permeation chromatography, is 56 kDa, and the subunit molecular mass is 30 kDa. The enzyme specifically hydrolyzes 3,4-dihydrocoumarin, and the Km and Vmax for 3,4-dihydrocoumarin are 0.806 mM and 4760 U.mg-1, respectively. The N-terminal and internal amino acid sequences of the enzyme show high similarity to those of bacterial non-heme haloperoxidases. The enzyme exhibits brominating activity with monochlorodimedon in the presence of H2O2 and 3, 4-dihydrocoumarin or an organic acid, such as acetate and n-butyrate.  (+info)

11 pages, 2 figures, 2 tables, 7 schemes.-- PMID: 18549274 [PubMed].-- Printed version published Jul 18, 2008.-- Supporting information available: Preparation of substrate 22, including spectroscopic data of the synthetic intermediates and the final product. Procedures for the allylation and alkylation reactions, and spectroscopic data of phenyl ketones 20, 21, 27, butenolides 28-33 and 37-39, and cyclohexanones 46, 47, and 49. 1H and 13C NMR spectra for acetoxy acetal 24, allyl derivatives 18 and 19, phenyl ketones 20, 21, 26, and 27, butenolides 28-39, cyclohexanones 46-48 and 50-55, alkaloid analogues 56-61, and substrates 63-65 and 22.-- Available at: http://pubs.acs.org/doi/suppl/10.1021/jo800478a ...
Several reports have indicated that nuclear factor-κB (NF-κB) is constitutively activated in a variety of cancer cells including hepatoma cells and plays a key role in their growth and survival. Dehydroxymethylepoxyquinomicin (DHMEQ) derived from the structure of an antibiotic epoxyquinomicin C is a novel NF-κB inhibitor. In the present study, we evaluated the effect of DHMEQ on the NF-κB activity in human hepatoma cells, Huh-7, HepG2 and Hep3B, and the anti-tumor effect of DHMEQ on these cells in vitro and in vivo. DHMEQ inhibited the steady-state transcriptional activity of NF-κB in all hepatoma cells. DHMEQ blocked the constitutive DNA-binding activity and TNF-α-mediated nuclear translocation of NF-κB in Huh-7 cells. DHMEQ (5-20 µg/ml) dose-dependently reduced the viable cell number of all hepatoma cells. DHMEQ (20 µg/ml) induced apoptosis in all hepatoma cells, especially in Hep3B cells, and cell-cycle arrest in Huh-7 and HepG2 cells. These effects were accompanied by downregulation ...
Enantioselective Total Synthesis of the Polyketide Natural Product (-)-EI-1941-2: A Novel Interleukin-1β Converting Enzyme (ICE) Inhibitor.|span||/span| | Goverdhan Mehta; Subhrangsu Roy | download | BookSC. Download books for free. Find books
Structure Elucidation of EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941.|span||/span| | Fumito Koizumi; Yuichi Takahashi; Hiroki Ishiguro; Rieko Tanaka; Shizuo Ohtaki; Mayumi Yoshida; Satoshi Nakanishi; Shun-ichi Ikeda | download | BookSC. Download books for free. Find books
Factory Supply 99% 1,4-Cyclohexanedione mono CAS: 69225-59-8 Basic Info. Name:1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal) CAS: 69225-59-8 MF: C11H18O3 MW: 198.26 EINECS: 273-918-4 mp 45-50...
Looking for TCI AMERICAS 1,4-cyclohexanedione monoethyleneketal (29LU08)? Graingers got your back. Price:$50.25. Easy ordering & convenient delivery. Log-in or register for your pricing.
Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group Public Comment Summary July 2019 Résumé des commentaires du public sur lébauche dévaluation préalable du groupe des lactones et cétones macrocycliques, des ionones et de la cyclohexanone Juillet 2019
The report generally describes 4,4-(ethylenedioxy)cyclohexanone, examines its uses, production methods, patents. 4,4-(Ethylenedioxy)cyclohexanone market
Insulin stimulated protein synthesis in L6 myoblasts but did not increase the labelling of DAG or the release of phosphocholine from phosphatidylcholine. The DAG lipase inhibitor, RHC 80267, more than doubled the amount of label appearing in DAG but did not stimulate protein synthesis. Even in the presence of the DAG lipase inhibitor insulin failed to have any effect on DAG labelling, and conversely RHC 80267 did not modify the insulin-induced increase in protein synthesis. These results suggest that endogenous DAG production is not involved in the stimulation of protein synthesis by insulin. However, exogenous diacylglycerols (1-oleoyl-2-acetyl glycerol and 1-stearoyl-2-arachidonoyl glycerol) both stimulated protein synthesis in L6 myoblasts. The efficacy of the former (arachidonatefree) DAG suggested that their action was by activation of protein kinase C rather than by arachidonate release and prostaglandin formation. Ibuprofen, an inhibitor of cyclo-oxygenase failed to block the effects of ...
2-(1-cyclohexen-1-yl)-2-methylpropanoic acid - chemical structural formula, chemical names, chemical properties, synthesis references
Benzene, 1,1-(3-cyclohexen-1-ylidene)bis- | C18H18 | CID 602040 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
s-[(3s)-3-methyl-1-cyclohexen-1-yl] ester c11h19nos (cas 255851 , 宽300x300高 , 显示比例:100% , 查看原图 , 图片来源 ...
102506-09-2 - SLSORSYCKMNPIJ-UHFFFAOYSA-N - (Cyclohexane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonicacid, sodium salt - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Cyclohexanone oxime is used primarily as a captive intermediate in the synthesis of caprolactam for the production of polycaprolactam (Nylon-6) fibers and plastics and also in a variety of industrial applications. Cyclohexanone oxime was selected for study because of the potential for human exposure and the interest in oximes as a chemical class. Toxicity studies of cyclohexanone oxime (approximately 99% pure) were carried out in male and female B6C3F1 mice; the compound was administered in drinking water for 2 weeks or 13 weeks. In addition, the genetic toxicity of cyclohexanone oxime was evaluated by determining mutagenicity in Salmonella typhimurium and induction of chromosomal aberrations in cultured Chinese hamster ovary cells in vitro, with and without S9 activation. The frequency of micronucleated normochromatic erythrocytes in the bone marrow and peripheral blood of mice from the 13-week study was also determined.. In the 2-week study, groups of five male and five female mice were given ...
... Brenntag is Beneluxs leading distributor and exporter of industrial chemicals and specialties, located in Belgium (Deerlijk, Antwerpen & Mouscron) and the Netherlands (Dordrecht, Loosdrecht, Zwijndrecht, Moerdijk, Rotterdam, Enschede).
0097] A reaction tank of a reaction container equipped with a stirrer, a thermometer, a reflux condenser, a dripping apparatus, and a gas introduction tube was charged with 250 parts of cyclohexanone and stirring at 80° C. was performed for 1 hour while blowing in nitrogen gas. 100 parts of LA87 as the monomer (a1), 125 parts of 4HBA as the monomer (a2), 25 parts of MMA as the monomer (a3), 7.5 parts of AIBN, and 80.9 parts of cyclohexanone were charged into a dripping tank and then dripped into the reaction tank over a period of 2 hours while stirring the contents of the dripping tank. After the end of dripping, the dripping tank was washed with 34.7 parts of cyclohexanone and the washing liquid was then placed in the reaction tank. After letting react for another 2 hours, a solution in which 2.5 parts of AIBN were dissolved in 22.5 parts of cyclohexanone was divided into three equal portions that were added on three occasions 30 minutes apart. 1 hour after the third addition, the reaction ...
View Notes - Chem331_Exam_Review from CHEM 331l at South Carolina. Cyclohexanone 12) 2,4-DNP 13) Triphenylmethanol 14) 4-Ethyl phenol 15) 1-ethyl-4-n-propoxybenzene Experiment 5 : Oxidation of
China Cyclohexanone-Qingdao Hisea Chem Co., Ltd, Find details about China Cyclohexanone, Cyc from Cyclohexanone-Qingdao Hisea Chem Co., Ltd - Qingdao Hisea Chem Co., Ltd.
Structure, properties, spectra, suppliers and links for: Ethyl (3R,4R,5S)-5-amino-4-[(1-|sup>11|/sup>C)ethanoylamino]-3-(3-pentanyloxy)-1-cyclohexene-1-c.
Learn more about Dimethyl-cis-4-cyclohexene-1,2-dicarboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
cyclohexane-1,3-dione 504-02-9 NMR spectrum, cyclohexane-1,3-dione H-NMR spectral analysis, cyclohexane-1,3-dione C-NMR spectral analysis ect.
Ethylbis(2-hydroxyethyl)oleylammonium ethyl sulphate 1-[(E)-pent-2-en-3-yl]naphthalene 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione 9H-Xanthen-9-one,3-[(1E)-2-[(1R,2R)-1,4- dimethyl-2-(1,4,5-trihydroxy-9-oxo-9Hxanthen- 3-yl)-3-cyclohexen-1-yl]ethenyl]-1,- 4,5-trihydroxy-,rel- Cobaltate(2-), (29H,31H-phthalocyanine-C,C-disulfonato(4-)-kappaN29,kappaN30,kappaN31,kappaN32)-, dihydrogen 2-[2-(4-aminophenyl)ethyl]-6-hydroxy-5-[4-(hydroxymethyl)-5-methyl-2-tert-butyl-phenyl]sulfanyl-2-phenyl-3H-pyran-4-one 8-Iso-19-noranthratestosterone 1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-2-isobutyl-5-(2-(6-methyl-3-pyridyl)ethyl)- N-[4-(4-acetylpiperazin-1-yl)phenyl]-3-chloro-benzamide Amosamine
ABSTRACT R1 R2 Mw RHC-1 -OCH3 -OCH3 396.42 RHC-2 -OCH3 -OH 368.37 RHC-3 -H -OH 308.32 RHC-4 -H -OCH3 336.39 RHC-5 -OH -OH 340.32 A selection of curcuminoids has been synthesized and complexed to HPβCD, MβCD and HPγCD ...
A series of octahydroacridine-1,8-diones have been synthesized in good yield via one-pot synthesis of corresponding tetrazolo[1,5-a]quinoline-4-carbaldehyde, 3-(4-fluorophenylamino)-5,5-dimethylcyclohex-2-enones and dimedone or cyclohexane-1,3-dione in acetic acid. All the synthesized compounds have been screened for antimicrobial and anti-tubercular activities ...
According to Regulation (EC) No. 1907/2006, Annex VIII, section 9.2.2.1, column 2, the study need not be conducted if the substance is highly insoluble in water or the substance is readily biodegradable. The water solubility of the test substance is 47 µg/L at 20 °C and is therefore classed as insoluble. Furthermore a Ready Biodegradability test shows 54.1% degradation after 28 days. Although this does not fulfill the minimum criteria set out by the OECD method, it does however indicate that the material achieved ,50 % within 30 days, highlighting its propensity for biodegradation. An inherent biodegradability test shows 80.5% degradation after 28 days, therefore it is considered that the material is inherently biodegradable and as such not persistent in environmentally significant conditions. Therefore given the poor solubility and propensity for biodegradation further studies are scientifically unjustified. ...
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TABLE-US-00001 TABLE 1 Peak and Relative Intensity Listing (degree 2θ, peaks with I/I1 value) Peak No. A I/I1 B I/I1 C I/I1 D I/I1 E I/I1 1 12.87 35 6.43 29 6.55 7 10.28 9 6.76 8 2 13.25 11 9.67 46 11.89 22 12.74 21 9.68 35 3 14.08 12 10.52 30 12.19 26 13.02 26 10.74 18 4 14.28 18 12.57 17 12.58 26 13.54 18 13.96 16 5 15.77 14 13.61 64 12.97 20 13.7 21 14.50 11 6 16.09 9 14.24 42 14.05 46 14.1 20 14.94 24 7 16.62 23 14.64 70 14.93 17 15.78 21 16.62 21 8 17.53 30 16.34 52 15.39 19 16.24 10 17.52 10 9 17.92 27 17.05 23 15.89 13 17.5 15 17.90 10 10 18.95 79 17.54 58 16.35 17 17.94 40 19.20 20 11 19.29 100 19.34 20 17.25 29 18.6 66 20.44 15 12 20.04 21 20.36 29 17.44 55 19.04 100 21.38 100 13 20.38 10 20.64 100 18.34 20 19.90 50 23.28 13 14 21.01 47 21.06 83 19.47 100 20.4 18 24.18 19 15 21.99 8 21.61 40 19.96 58 21.1 17 25.16 12 16 23.84 8 22.06 33 21.14 48 21.92 10 25.18 12 17 24.68 17 23.17 23 22.27 15 23.58 23 25.20 10 18 25.28 40 23.56 23 22.84 9 25.3 19 25.22 11 19 25.83 9 23.92 15 23.37 40 ...
There are 9 thirteen-letter words containing A, H, 2N, O and X: ANDROSPHINXES ANTHOXANTHINS CYCLOHEXANONE ... PHYCOXANTHINS XANTHOPTERINE XANTHOPTERINS. Every word on this site is valid scrabble words. Build other lists, that start with or end with letters of your choice.
There are 14 thirteen-letter words containing A, H, L, N and X: CHALCEDONYXES CYCLOHEXANONE EXHILARATIONS ... NONHOMOSEXUAL XIPHIPLASTRON ZOOXANTHELLAE. Every word on this site can be played in scrabble. See other lists, starting with or ending with letters of your choice.
MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinone2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (TIGR00173; EC 2.2.1.9; HMM-score: 57.6) ...
The hydrogenation of a number of unsaturated compounds containing carbon-oxygen bonds has been studied. In most cases the reactions were performed at 30C and one atmosphere pressure of hydrogen, over Adams platinum oxide catalyst, in 50ml. of a solvent, usually containing some acid. It has been concluded from the results obtained that :- (1). Hydrogenolysis of the carbon-oxygen bond is always prevalent when acid or acidified solvents are used with a substrate having a centre of unsaturation close to the carbon-oxygen link. Thus under these conditions phenols, benzyl alcohols, allylic alcohols and cyclohexanones cleave readily. Removal of the centre of unsaturation from the vicinity of the carbon-oxygen bond renders it less liable to hydrogenolysis, as shown by the considerably smaller cleavage of ?-phenyl ethyl alcohol. The kinetics of the hydrogenolysis of phenols and benzyl alcohols show marked similarities with the kinetics of the hydrogenolysis of the corresponding phenyl and benzyl ...
TY - JOUR. T1 - Discovery of the first non-planar flavonoid that can strongly inhibit xanthine oxidase. T2 - Protoapigenone 1′-O-propargyl ether. AU - Hunyadi, Attila. AU - Martins, Ana. AU - Danko, Balazs. AU - Chuang, Da Wei. AU - Trouillas, Patrick. AU - Chang, Fang Rong. AU - Wu, Yang Chang. AU - Falkay, George. PY - 2013/11/27. Y1 - 2013/11/27. N2 - Xanthine oxidase (XO) is a key enzyme in purine metabolism with an important role in various pathologies. Several flavonoids have been reported for their capacity to inhibit this enzyme, and, for these compounds, the ability to adopt a planar 3D structure has been accepted as fundamental prerequisite for such activity. Here we report the in vitro investigation of a series of non-planar protoflavone derivatives as XO inhibitors, among which protoapigenone 1′-O-propargyl ether was found to be an efficient competitive inhibitor of the enzyme with an IC50 value of 3.61 μM, significantly (p ,0.001) stronger than the anti-gout drug allopurinol ...
Looking for online definition of Diacylglycerol lipase in the Medical Dictionary? Diacylglycerol lipase explanation free. What is Diacylglycerol lipase? Meaning of Diacylglycerol lipase medical term. What does Diacylglycerol lipase mean?
Process for the preparation of phenol and cyclohexanone which comprises: a. the synthesis of cyclohexylbenzene by the hydro-alkylation of benzene by contact with hydrogen or the alkylation of benzene with cyclohexene using Y zeolites; b. the selective aerobic oxidation of cyclohexylbenzene to the corresponding hydroperoxide catalyzed by N-hydroxy-derivatives in the presence of polar solvents; and c. the scission of the hydroperoxide of cyclohexylbenzene to phenol and cyclohexanone by homogeneous or heterogeneous acid catalysts; characterized in that the synthesis of cyclohexylbenzene takes place in the presence of a catalytic system comprising a Y zeolite and an inorganic ligand wherein the Y zeolite has a crystalline structure with openings consisting of 12 tetrahedra and the inorganic ligand is -alumina, and wherein said catalytic composition is characterized by a pore volume, obtained by adding the mesoporosity and macroporosity fractions, greater than or equal to 0.7 cm3/g, wherein at ...
endo-1,3-β-D-Glucanase (Trichoderma sp.) [ME-LAMSE] - High purity endo-1,3-beta-Glucanase (Trichoderma sp.) for use in research, biochemical enzyme assays and in vitrodiagnostic analysis. EC 3.2.1.39 From Trichoderma sp. Highly purified. In 3.2 M ammonium sulphate. Specific Activity: ~ 15 U/mg (40oC, pH 4.5, CM-Curdlan as substrate). Stable at 4oC for | 4 years.
3-(2-oxopropyl)-1-cyclohexen-1-yl acetate - chemical structural formula, chemical names, chemical properties, synthesis references
Page contains details about tris({[(9,10-dioxo-8a,9,10,10a-tetrahydroanthracen-2-yl)amino]methylidene})cyclohexane-1,3,5-trione nanowires . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Buy high quality 4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid Salt 359436-59-2 from toronto research chemicals Inc.
472-64-0 - YJKGMUJSGUUUJU-UHFFFAOYSA-N - 2-Cyclohexene-1-acetaldehyde, 2,6,6-trimethyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Read "Molecular structure investigation and biological evaluation of Michael adducts derived from dimedone, Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane, compounds found in cruciferous vegetable, are highly effective in inducing cell cycle arrest and apoptosis in a variety of cancer cells and animal models. Although some studies indicate that ITC-induced reactive oxygen species (ROS) generation may underlie apoptosis induction, our recent studies show that covalent binding to target proteins may be an important event triggering apoptosis. In this study, we report that BITC and PEITC significantly inhibit proteasome activity in a variety of cell types. Further studies show that ITCs inhibit both the 26S and 20S proteasomes, presumably through direct binding, and that this inhibition is unrelated to either ROS generation or ITC-induced protein aggregation. The potency of ITC-induced proteasome inhibition correlates with the rapid accumulation of p53 (tumor suppressor) and IκB nuclear factor-kappaB (nuclear factor-kappaB inhibitor). ...
Cyclohexanone is an aliphatic cyclic ketone. Cyclohexanone derivatives have potent pharmacological activity in the treatment of a broad spectrum of medical conditions (Puetz et al., 2003). The cyclohexanone moiety constitutes an important structural feature in several anti-inflammatory, analgesic, local anesthetic and antihistaminic drugs (Rajveer et al., 2010). As part of our studies in this area (Fatima et al., 2013; Hema et al., 2006), we have undertaken a single-crystal structure determination of the title compound.. In the title compound, Fig. 1, the cyclohexene ring (C9-C14) adopts an envelope conformation with atom C13 as the flap: puckering parameters (Cremer & Pople, 1975) are Q = 0.464 (3) Å, θ = 52.3 (4) °, and ϕ = 232.2 (4) °. Its mean plane makes a dihedral angle of 7.20 (12)° with the benzene ring (C1-C6).. In the crystal, hydrogen bonded chains running along the a-axis direction are generated by connecting neighbouring molecules via C-H···O hydrogen bonds (Table 1 and ...
BioAssay record AID 504420 submitted by The Scripps Research Institute Molecular Screening Center: Summary of the probe development efforts to identify inhibitors of human diacylglycerol lipase, beta (DAGLB).
The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: ##STR00001## wherein G represents a galloyl group; theasinensins represented by the formula: ##STR00002## wherein R.sub.1 represents G or H, and R.sub.2 represents G; and theaflavins represented by the formula: ##STR00003## wherein R.sub.1 and R.sub.2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
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Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, IR Spectrum, Mass spectrum (electron ionization), References, Notes. Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved. Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. Note: Please consider using the reaction search for this species. This page allows searching of all reactions involving this species. A general reaction search form is also available. Future versions of this site may rely on reaction search pages in place of the enumerated reaction displays seen below. ...
A total synthesis of the complex, bent aromatic ring-containing marine alkaloid haouamine A is achieved through a route in which every step (with the exception of the final deprotection) is performed on a gram-scale. This is accomplished through the development of a method for the dehydrogenation of cyclohexenones that allows for point-to-planar chirality transfer. This strategy makes it possible to program the desired atropisomeric outcome from a simple chiral cyclohexenone. By synthesizing atrop-haouamine A, this work has firmly established that natural haouamine exists as a single, nonequilibrating atropisomer. Finally, biological investigations demonstrate that the bent aromatic ring of this natural product is critical for anticancer activity against PC3 cells ...
A phosphate-free automatic dishwashing cleaning composition comprising a crystal growth inhibitor system comprising cyclohexane-1,2,3,4,5,6-hexacarboxylic acid (CHHCA) and cyclopentane-1,2,3,4-tetracarboxylic acid (CPTCA).
On the basis of medical and environmental data collected at the Water Well Drillers (SIC-4619) in Western Tennessee, the use of polyvinyl-chloride (PVC) cement is not found to constitute a health hazard under existing conditions of use. Environmental samples show only low levels of tetrahydrofuran (109999) and no detectable levels of cyclohexanone (108941). Responses to medical questionnaires indi
AP-1 and NF-κB inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the ...
Title:Organocatalyzed Transient Dienamine-Mediated Diels-Alder Reactions between α,β-Unsaturated Ketones and Alkenes. VOLUME: 15 ISSUE: 5. Author(s):Iosune Arrastia, Ana Arrieta and Fernando P. Cossio*. Affiliation:Donostia International Physics Center, San Sebastian/Donostia, Donostia International Physics Center, San Sebastian/Donostia, Donostia International Physics Center, San Sebastian/Donostia. Keywords:Organocatalysis, diels-Alder reactions, cycloadditions, michael additions, pericyclic reactions, stepwise mechanisms.. Abstract:Organocatalyzed (4+2) cycloadditions (Diels-Alder reactions) are reviewed in this manuscript. Among the different catalytic alternatives, reactions involving α,β-unsaturated ketones and alkenes are considered. In these processes, substituted cyclohexanones are obtained via HOMO activation generated by amine organocatalysis that generate transient dienamine species. Both concerted and stepwise mechanisms are described. In most cases, excellent regio-, ...
Welcome to the Big & Dandy Methoxetamine Thread http://upload.wikimedia.org/wikipedia/commons/thumb/0/03/Methoxetamine.png/220px-Methoxetamine.png http://freebiesforwebsites.com/deviders/novdevider7.gif Previous B&Ds: Previous Big & Dandy Methoxetamine Thread Older Big & Dandy Methoxetamine Thread More Previous Big & Dandy Methoxetamine Thread
(-)-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol - Surfactant - SAAPedia - SAAPedia(Surfactant.TOP),Surfactant,Anionic surfactants, Cationic surfactants, Non-ionic surfactants, Zwitterionic surfactants, Polymer Surfactants, Fluoro surfactants, Silicone surfactants, Biosurfactants, Natural surfactants, Special surfactants - Page1
Cyclohexanone, Gibberellic Acid, Micro Irrigation, Micro Mix, Zinc Sulphate, Protein Hydrolysate Granules, Pheromones Lures, Bio Fertilizer Product, Seeds, Pearl Millet Seeds, Cotton Seeds, Bio Fuels & Manufacturer Of Biotech Product In India
Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The work described in this thesis has led to the identification of an activity-based probe (ABP) for DAGL-α. This ABP was instrumental for the identification of a new class of highly selective DAGL inhibitors. These novel inhibitors can be used to investigate the role of the diacylglycerol lipases in metabolic syndrome and neurodegenerative diseases such a Parkinsons disease, Alzheimers disease and Multiple Sclerosis ...
3.0.CO;2-S. PMID 11093146. Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1-7. doi:10.1006/cyto.2000.0799. PMID 11145836. Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597-602. doi:10.1074/jbc.M010095200. PMID 11278614. Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440-6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363. Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536-7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262. Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". ...
We synthesize peptides with arginine modifications (citrulline & nitro-arginine), lysine modifications (succinylation, malonylation & acylation), and more
A highly enantioselective addition of cyclohexenone to different aldehydes (asymmetric Morita-Baylis-Hillman reaction) catalyzed by octahydro-BINOL-derived Brønsted acid (669172) was reported by Schaus (Scheme 15). Important for achieving high enantioselectivity were both the partial saturation and substitution at the 3,3-positions of the BINOL derivative.1. ...
Crested wheatgrass [Agropyron cristatum (L.) Gaertn., A. desertorum (Fisch. ex Link) Schult., and related taxa] often exists in near monoculture stands in the northern Great Plains. Introducing locally adapted yellow-flowered alfalfa [Medicago sativa L. subsp. falcata (L.) Arcang.] would complement crested wheatgrass. Our objective was to evaluate effects of seeding date, clethodim {(E) -2-[1-[[(3-chloro-2-propenyl)oxy]imino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one} sod suppression, and seeding rate on initial establishment and stand persistence of Falcata, a predominantly yellow-flowered alfalfa, no-till interseeded into crested wheatgrass. Research was initiated in August 2008 at Newcastle, WY; Hettinger, ND; Fruitdale, SD; and Buffalo, SD. Effects of treatment factors on plant frequency during initial establishment were influenced by site environments. Late summer and spring were suitable seeding dates. Clethodim sod suppression increased seedling frequency in most cases. Seedling
Developmental toxicity The appropriate read-across candidate of delta-damascone, alpha-iso-methylionone (EC name:3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one) was tested in an oral (gavage) developmental toxicity study with rats (Charles River, 2005) One hundred pregnant Crl: CD®(SD) IGS BR VAF/Plus® rats were randomly assigned to four dosage groups, 25 rats per group. The test article, alpha-iso-methylionone, and/or the vehicle, corn oil, was administered to the rats orally (gavage) once daily on days 7 through 17 of presumed gestation (gestation days (GD) 7 through 17) at dosages of 0, 3, 10 and 30 mg/kg bw/day. The dosage volume was 10 mL/kg, based on individual body weights recorded daily before administration. Viabilities, clinical observations, body weights and feed consumption values were recorded. All rats were sacrificed on GD 21, Caesarean-sectioned and examined for the number and distribution of corpora lutea, implantation sites and uterine contents. A gross necropsy ...
Lycosin-I is a linear amphipathic α-helical anticancer peptide (ACP) extracted from the spider Lycosa singoriensis, which can activate the mitochondrial death pathway to induce apoptosis in tumor cells and up-regulate p27 to inhibit cell proliferation. However, the applicability of lycosin-I as a novel antic
Reaction of 4-(1-hydroxy-1-methylethyl)-3-cyclohexen-1-one with a 5-substituted resorcinol in the presence of boron tribromide, boron trifluoride or stannic chloride provides, depending upon the durat
This gene has been functionally characterized as a diacylglycerol-lipase (DAGL), referred to as DAGL beta. These enzymes may have a role in the biosynthesis of the endocannabinoid 2-arachidnoyl glycerol (2-AG ...
The six step synthesis of the new imidazole-like heterocycle 1,6-diazaphenalene (8) from readily available cyclohexane-1,3-dione 1 and dimethyl beta-ketoglutarate 2 is described. In addition, a six step synthesis of 9-methoxy-diazaphenalene (34) from ethylacetoacetate and p-ansidine has also been accomplished. An investigation of the chemistry of 8 has been carried out and resulted in several routes to key 7-substituted-1,6-diazaphenalenes such as 10, 15, 16, and 17, as well as conditions under which to N-alkylate 8. In fact, this alkylation sequence has resulted in the preparation of the target 17. The reaction of 1,6-diazaphenalene with singlet oxygen and peracids has also been determined as well as preparation of several key derivatives in the 9-methoxy-series.*Antimalarials
PURINONE DERIVATIVE | PROCESS FOR MAKING TRICYCLIC LACTAM COMPOUNDS | Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine Compounds | HISTONE DEMETHYLASE INHIBITORS | Fused Heterocyclic Compounds as Selective BMP Inhibitors |
Surfaces with primary or secondary amino groups covalently bound are dedicated to promote the covalent immobilisationof compounds containing reactive moieties such as amino, carboxyl or thiol groups via well-known homoheterobifunctionallinkers, e.g. N-Hydroxysuccinimide (NHS) or Succinimidyl 4-(N-maleidomethyl) cyclohexane-1-carboxylate (SMCC).. This kind of immobilisation can overcome some of the limitations connected with physical adsorption of the molecules tothe surfaces:. ...
Surfaces with primary or secondary amino groups covalently bound are dedicated to promote the covalent immobilisationof compounds containing reactive moieties such as amino, carboxyl or thiol groups via well-known homoheterobifunctionallinkers, e.g. N-Hydroxysuccinimide (NHS) or Succinimidyl 4-(N-maleidomethyl) cyclohexane-1-carboxylate (SMCC).. This kind of immobilisation can overcome some of the limitations connected with physical adsorption of the molecules tothe surfaces:. ...
With regards to conjugation to KLH, Globo-H, MUC1-32mer, GM2, Lewis Y, Tn(c), STn(c), and TF(c) were covalently attached to KLH directly by reductive amination (GM2), using the 4-(4-maleimidomethyl) cyclohexane-1-carboxyl hydrazide heterobifunctional linker group (Globo-H and Lewis Y) and using the m-malemidobenzoyl-N-hydroxysuccinimide ester heterobifunctional linker group [MUC1, Tn(c), STn (c), and TF (c)] as described previously (18, 20-25, 29). The structures of these seven conjugates are summarized in Fig. 1. Antigen and adjuvant doses were selected based on previous phase 1 monovalent vaccine trials as follows: 3 μg Tn-MUC1-32mer (24), 10 μg Globo-H (15, 22), 10 μg GM2 (30), 10 μg Lewis Y (20), 3 μg Tn(c) (23), 3 μg STn(c), 3 μg TF(c) (18), and 100 μg QS21 (15, 30). These seven conjugates and QS21 were vialed together in 1 mL PBS. Vialed samples underwent testing for toxicity and immunogenicity in mice, as well as for sterility and endotoxin. Vaccines were given s.c. on weeks 1, 2, ...
Yet another scheme is known for the synthesis of this class of compounds. An enamine is prepared by the dehydration of equimolar quantities of piperidine and cyclohexanone. The addition of anhydrous p-toluene sulfonic acid or of hydrogen bromide to this system produces an adduct from which PCP can be obtained by displacement with a Grignard reagent9.. The majority of the illicitly synthesized PCP is prepared according to the general directions of Kalir et al.7, modified in details as required by the availability of chemicals and equipment. A typical batch operation will be on a 3- to 5-mole scale, and is usually limited by the amount of piperidine to be used (usually a maximum of 500 gm). Of all the reagents needed in this preparation, this last is the most difficult to obtain and can command as much as $1000/kg for a clean bottle (i.e., one which is not watched or traceable). The procedure given in Ref. 7 for the preparation of PCC (2) is followed religiously, except that if the product does ...
Cyclohexanone oxime (CHOX), an intermediate used in the synthesis of Polycaprolactam/Nylon, was found to be rapidly absorbed and cleared from the body within 24 hours after a single oral administration of 1, 10 and 30 mg/kg of [14C]-CHOX to the adult male Fischer rats. The majority of the CHOX derived radioactivity (65-90% of the dose) was excreted in the urine. Elimination in the feces accounted for 5-10% of the dose and very low levels of radioactivity (2-3%) were retained in the tissues 24 hours after exposure. After iv administration of 1 mg/kg of [14C]-CHOX, the oxime was rapidly cleared from plasma with half-lives of 1.6 (alpha phase) and 18.2 min (beta phase). However, when CHOX was applied dermally (30 mg/kg), only about 4-5% of the dose was recovered in urine, feces and the tissues. The majority of the dose volatilized from the skin surface. However, the absorbed oxime was readily distributed and excreted, and its metabolic fate was no different than observed after oral administrations. ...
You may also wish to search for items by Evans. 22 matching references were found. Wallach, O.; Evans, E., Knowledge of Terpenes and Essential Oils III. Condensaton of Cyclo-1,4-methylhexanone with «alpha»-Bromopropionic Acid, Justus Liebigs Ann. Chem., 1908, 360, 52-5. [all data] Wallach, O.; Evans, E., Knowledge of Terpenes and Essential Oils I. Condensation of Cyclohexanone with «alpha»-Bromopropionic Acid, Justus Liebigs Ann. Chem., 1908, 360, 44-50. [all data] Wallach, O.; Evans, E., Knowledge of Terpenes and Essential Oils II. Condensation of Active Cyclo-1,3-methylhexanone with «alpha»-Bromopropionic Acid, Justus Liebigs Ann. Chem., 1908, 360, 51-52. [all data] Wallach, O.; Evans, E., Justus Liebigs Ann. Chem., 1906, 347, 345. [all data] Corbett, R.E.; McDowall, M.A.; Bowen, E.J.; Sahu, J.; Bunton, C.A.; Israel, G.; Mhala, M.M.; Williams, D.L.H.; Katritzky, A.R.; Monro, A.M.; Beard, J.A.T.; Bladon, Peter; Huang, R.L.; Dalgliesh, C.E.; Kelly, W.; Cox, R.A.; Swallow, A.J.; Dick, ...
2-Methylene analogs of 1alpha-hydroxy-19-norvitamin D3: synthesis, biological activities and docking to the ligand binding domain of the rat vitamin D receptorGrzywacz, P. et al.The Journal of Steroid Biochemistry and Molecular Biology 89-90, 13-7, 2004. ...
This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Browse many computed properties for this monoclinic Sc3RhC4 compound, including formation energy from the elements, energy of decomposition into the set of most stable materials at this chemical composition, bulk crystalline density, and band gap. Also known as: Triscandium rhodium tetracarbide. Cite this material using DOI 10.17188/1273886.
Dortmund Data bank - Thermophysical Properties | Benzene, CAS Number: 71-43-2 | Cyclohexanol, CAS Number: 108-93-0 | SpringerMaterials 2014
pentaerythritol tetranitrate reductase: catalyzes denitration of pentaerythritol tetranitrate with NADPH to 3-hydroxy-2,2-bis-((nitroxy)methyl)propanal and 2,2-bis-((nitroxy)methyl)-propanedial; isolated from Enterobacter cloacae
TY - JOUR. T1 - Megastigmane glycosides and an acylated triterpenoid from Eriobotrya japonica. AU - Ito, H.. AU - Kobayashi, E.. AU - Li, S. H.. AU - Hatano, Tsutomu. AU - Sugita, D.. AU - Kubo, N.. AU - Shimura, S.. AU - Itoh, Y.. AU - Yoshida, T.. PY - 2001. Y1 - 2001. N2 - Two new megastigmane glycosides, eriojaposides A (1) and B (2), and a new acylated triterpenoid (3) were isolated along with nine known compounds from a leaf extract of Eriobotrya japonica. The structures of 1-3 were characterized as (6R,9R)-3-oxo-α-ionyl-9-O-β-xylopyranosyl- (1″→6′)-β-glucopyranoside, (6R,9R)-3-oxo-α-ionyl-9-O-α-rhamnopyranosyl- (1″→6′)-β-glucopyranoside, and 3α-trans-feruloyloxy-2αhydroxyurs-12-en-28-oic acid, respectively, on the basis of spectral and chemical evidence.. AB - Two new megastigmane glycosides, eriojaposides A (1) and B (2), and a new acylated triterpenoid (3) were isolated along with nine known compounds from a leaf extract of Eriobotrya japonica. The structures of 1-3 ...
Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. The primary role of lipase inhibitors is to decrease the gastrointestinal absorption of fats. Fats then tend to be excreted in feces rather than being absorbed to be used as a source of caloric energy, and this can result in weight loss in individuals. These inhibitors could be used for the treatment of obesity, which can subsequently lead to Type II diabetes and cardiovascular diseases if not managed. An example of a lipase inhibitor is orlistat. Lipase inhibitors may affect the amount of fat absorbed, yet they do not block the absorption of a particular type of fat. Likewise, lipase inhibitors are not absorbed into the bloodstream. Lipase inhibitors bind to lipase enzymes in the intestine, thus preventing the hydrolysis of dietary triglycerides into monoglycerides and fatty acids. This then reduces the absorption of dietary fat. Lipase ...
Pentaerythritol tetranitrate (PETN), a nitrate ester, is widely used as a powerful explosive and is classified as a munitions constituent of great concern by DoD in U.S.A. It is an environmental concern and poses a threat to ecosystem and human health. Our objective was to examine potential remediation strategies for both PETN-contaminated water and soil. Flow-through iron columns were used to determine the potential for using granular iron to degrade PETN in aqueous phase. PETN transformation in both a 100% iron column and a 30% iron and 70% silica sand column followed pseudo-first-order kinetics, with average half-lives of 0.26 and 1.58 minutes, respectively. Based on the identified intermediates and products, the reaction pathway was proposed to be a sequential denitration process, in which PETN was stepwisely reduced to pentaerythritol with the formation of pentaerythritol trinitrate (PETriN) and pentaerythritol dinitrate (PEDN). Although pentaerythrito mononitrate was not detected, an ...
TY - JOUR. T1 - Arginine-specific reagents remove sodium channel inactivation. AU - Eaton, Douglas C.. AU - Brodwick, Malcolm S.. AU - Oxford, Gerry S.. AU - Rudy, Bernardo. PY - 1978/12/1. Y1 - 1978/12/1. N2 - PROTEINS are often suggested to be the molecular components of excitable membranes which confer voltage-dependent permeability properties on nerve and muscle cells. Because of the relatively low concentration of the protein molecules directly responsible for ionic conductances compared with other membrane components, the isolation, characterisation, and reconstitution of these proteins is still at a rather early stage. Certain aspects of the molecular nature of the conductance mechanisms of excitable tissues, however, can be deduced using chemical reagents which specifically modify protein molecules. In particular, the sodium inactivation process can be eliminated by treatment with various proteolytic enzymes1-3,6. Of these, trypsin is probably the most selective, cleaving mainly at ...
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3-MeO-2-Oxo-PCE (commonly known as Methoxetamine, MXE, Mexxy, among others) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered. It is structurally related to ketamine, PCE, and 3-MeO-PCP.[1]
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) PENTAERYTHRITOL TETRANITRATE NTP Experiment-Test: 05023-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/04/94 Route: DOSED FEED Time: 00:40:08 Facility: TSI Mason Research Chemical CAS #: 78-11-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94 Route: DOSED FEED Time: 00:40:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25% ...
ABSTRACT. Electrophilic substitution reaction of indole with various aldehydes and cyclohexanone were carried out in the presence of electron-transfer (K5CoW12O40.3H2O) and green Lewis acid ([(n-C4H9)4N]3PMo2W9(Sn4+.H2O)O39) catalysts. These catalysts were characterized by N2-adsorption measurements, FT-IR, UV-Vis, 31P NMR, TGA, cyclic voltammetry and elemental analysis. Mechanisms for their catalytic activity are proposed. Both of these catalysts can be recovered and reused.. Keywords: Dodecatungstocobaltate, Sn (IV)-substituted polyoxometalate, bis(indolyl)methanes, electrophilic substitution, solvent-free conditions. ...
Wang, Yei-Zeng. A new species and a new record of Lachnum from Taiwan. Mycotaxon 87: 137 - 140. 2003.. ABSTRACT: A new species and a new record of Lachnum are described and illustrated from Taiwan. The new species, Lachnum meifengense, is characterized by its foliicolous habitat, white apothecia, fusiform ascospores, and lanceolate paraphyses. A newly recorded species, Lachnum patenum, is recognized by its white apothecia and long fusiform ascospores. KEYWORDS: discomycetes, Helotiales, Hyaloscyphaceae. ...
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Hey guys, just decided to finally join a forum which discuss HPPD. 3 years ago when I was heavy into my drug use I was out at a club and a friend I k...
A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST ...
Although rare, some people whove taken hallucinogenic substances develop hallucinogen persisting perception disorder (HPPD), a sensory disorder. Learn more.
Synonyms: HPPD, flashbacks This condition occurs in those who have previously taken hallucinogenic recreational drugs, usually on a number of occasions....
Experimental details for the isolation of compounds 1-10 3, 4 S1: H-NMR spectrum of 1-octacosanol ( 1) in CDCl3 (300 MHz) 5 S2: C… Expand ...
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Takeda, Y; Zhang, HJ; Masuda, T; Honda, G; Otsuka, H; Sezik, E; Yesilada, E; Sun, HD.Megastigmane glucosides from Stachys byzantina,PHYTOCHEMISTRY,1997,44(7):1335-1337 ...
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Sorghum acreage is declining throughout the United States because management options and yield have not maintained pace with maize improvements. The most extreme difference has been the absence of herbicide technology development for sorghum over the past twenty years. The objectives of this study were to evaluate the level of resistance, type of inheritance, and causal mutation of wild sorghums that are resistant to either acetyl-coenzyme A carboxylase (ACCase)-inhibiting herbicides or acetohydroxyacid synthase (AHAS)-inhibiting herbicides. ACCase-inhibiting herbicides used in this study were aryloxyphenoxypropionate (APP) family members fluazifop-P and quizalofop-P along with cyclohexanedione (CHD) family members clethodim and sethoxydim. The level of resistance was very high for APP herbicides but low to nonexistent to CHD herbicides. With genetic resistance to APP herbicides, the resistance factors, the ratio of resistance to susceptible, were greater than 54 to 64 for homozygous individuals ...
We have cloned and purified three recombinant Arabidopsis OPRs, OPR1, OPR2, and OPR3, which exhibit significant (43%, 44%, and 36%, respectively) identity with bacterial pentaerythritol tetranitrate reductase, a member of the Old Yellow Enzyme family that is able to transform TNT. The greatest degree of similarity, both structurally and in regulation, exists between OPR1 and OPR2, and both are up-regulated in the root on exposure to TNT (Biesgen and Weiler, 1999). However, OPR1 had the greatest increase in expression in response to TNT treatment, suggesting a more dominant role in detoxification. The mechanism of TNT uptake and the intracellular site of accumulation are not known; however, while OPR1 and OPR2 are predicted to be active in the cytosol, OPR3 is targeted to the peroxisome, and this localization is likely to reduce accessibility toward TNT in planta.. The in vitro activity data clearly show that OPR1, OPR2, and OPR3 all have activity toward TNT. In liquid culture, the overexpressing ...
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Tyrosinemia, Type III (TYR-III) is an inborn error of metabolism, an inherited condition in which an enzyme, 4-hydroxyphenylpyruvate dioxygenase, in the body is either missing or not working well. Tyrosinemia Type III is considered an amino acid condition because the body is unable to break down the amino acid (part of protein), known as tyrosine, when this enzyme is not working properly. This condition is rare and the signs and symptoms of TYR-III can be variable and are not yet well defined.. For more information about Tyrosinemia, Type III, go to Babys First Test: Tyrosinemia, Type III. A listing of contact information for Minnesota inborn errors of metabolism medical specialty providers/clinics serving children affected with or undergoing evaluation for conditions that can be detected through Minnesota Newborn Screening is available upon request. ...
TITLE 14. CRIMINAL LAW. CHAPTER 1. CRIMINAL CODE. PART V. OFFENSES AFFECTING THE PUBLIC MORALS. SUBPART B. OFFENSES AFFECTING GENERAL MORALITY. 2. OFFENSES AFFECTING THE HEALTH AND MORALS OF MINORS. 14:93.1 Model glue; use of; abuse of toxic vapors; unlawful sales to minors; penalties. A. Definitions:. (1) The term "model glue" shall mean any glue or cement of the type commonly used in the building of model airplanes, boats and automobiles and which contains one or more of the following volatile solvents: (a) toluol, (b) hexane, (c) trichlorethylene, (d) acetone, (e) toluene, (f) ethyl acetate, (g) methyl ethyl ketone, (h) trichlorochthane, (i) isopropanol, (j) methyl isobutyl ketone, (k) methyl cellosolve acetate, (l) cyclohexanone, or (m) any other solvent, material, substance, chemical or combination thereof having the property of releasing toxic vapors.. (2) "Abuse of toxic vapors" shall mean to smell or inhale the fumes of any solvent, material, substance, chemical or combinations thereof ...
The present studies demonstrate that the organic nitrate PETN but not ISMN improves vascular function and reduces oxidative stress via inhibition of vascular superoxide production in mitochondria and by inhibition of the vascular NADPH oxidase in an experimental model of AT-II-induced hypertension. In almost all of the animal models where endothelial dysfunction is encountered, such as atherosclerosis,23 chronic congestive heart failure,24 AT-II-induced hypertension,4 and diabetes mellitus,25 we established that increased production of ROS via activation of the vascular NADPH oxidase and xanthine oxidase contributed considerably to this phenomenon. Interestingly, in all of the models, eNOS expression was upregulated rather than downregulated, suggesting that eNOS might be dysfunctional, as uncoupled under these circumstances.4,23-25. Previously, it was conceptualized that treatment with an exogenous source of NO (eg, GTN) could compensate for the diminished endothelial NO availability in ...
Additionally, the reactivity of two series of ketones are in the orders Cl3CCOCH3 > CH3COCH3 > C6H5COCH3 and cyclohexanone > ... For instance, the reaction of cyclopentanone with diazomethane forms cyclohexanone (shown below). The Büchner ring expansion ... Giraitis, Albert; Jesse Bullock (May 1937). "Reactions of Cyclohexanone with Diazoethane". Journal of the American Chemical ...
The oil contains 80% to 92% of cyclohexanone pulegone. Pulegone, the molecule in highest concentration in the pennyroyal plant ...
Tamio Hayashi, Makoto Takahashi, Yoshiaki Takaya, and Masamichi Ogasawara (2004). "(R)-3-phenyl-cyclohexanone". Organic ... 3-phenyl-cyclohexanone from cyclohexenone, phenylboronic acid, a rhodium acac catalyst and the chiral ligand BINAP.[2] In ... cyclohexanone. Conjugated carbonyls react with hydrogen cyanide to 1,4-keto-nitriles. See hydrocyanation of unsaturated ...
R. B. Woodward, I. J. Pachter, and M. L. Scheinbaum (1974). "2,2-(Trimethylenedithio)cyclohexanone". Organic Syntheses. 54: 39 ...
ISBN 0-8247-7764-6 R. B. Woodward, I. J. Pachter, and M. L. Scheinbaum (1974). "2,2- (Trimethylenedithio)cyclohexanone". ...
This rearrangement first creates the vinyl oxazolidine from attack on the cyclohexanone by the aminobutenol, which then ... Upon formation, Overman showed that cyclohexanones can be used for the carbonyl component in pyrrolidine synthesis. This ... highlighting the thermodynamic favorability of releasing cyclohexanone from the double bonded carbonyl, as it creates ... reaction proceeded with various forms of cyclohexanones. When an acyclic ketone was substituted, the reaction proceeded with ...
Hydrogenation gives the cyclohexanone derivative. Epoxidation with basic hydrogen peroxide affords the oxide. Isophorone is ...
... for the oxidation of cyclohexanone; an alcohol dehydrogenase for oxidation of the "double-smart cosubstrate" 1,6-hexanediol; ...
2-methylamino cyclohexanone HCl (CI-581)". Anesthesiology. 28 (5): 823-33. doi:10.1097/00000542-196709000-00008. PMID 6035012. ...
For example, consider the compound methyl cyclohexanone-4-carboxylate, where lithium aluminium hydride reduction will produce 4 ... involves acetalisation of cyclohexanone)". Organic Syntheses. ; Collective Volume, 5, p. 303 Greene, Theodora W.; Wuts, Peter G ...
The plant was re-built but cyclohexanone was now produced by hydrogenation of phenol (Nypro proposed to produce the hydrogen ... causing a small percentage of the cyclohexane to oxidise and produce cyclohexanone, some cyclohexanol also being produced. Each ... The caprolactam was produced from cyclohexanone. This was originally produced by hydrogenation of phenol, but in 1972 ... including one in which cyclohexane was oxidised to cyclohexanone and cyclohexanol). Historically good process safety ...
RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone. Kimlik belirteçleri. CAS numarası. 6740-88-1. ...
ε-Caprolactam: Crude oil → benzene → cyclohexane → cyclohexanonecyclohexanone oxime → caprolactam. *11-aminoundecanoic acid ... Adipic acid: Crude oil → benzene → cyclohexane → cyclohexanone + cyclohexanol → adipic acid. *Sebacic acid (decanedioic acid): ...
It is a metal-mediated rearrangement of enol ether pyrans to cyclohexanones. Typically, this reaction is catalyzed by mercury ... used the Ferrier conditions to synthesise complex conjugated cyclohexanones in 1998. Ferrier, RJ (1979). "Unsaturated ...
This latter product is oxidized to a hydroperoxide and then cleaved to phenol and cyclohexanone. Cyclohexanone is an important ... Partial hydrogenation of phenol gives cyclohexanone, a precursor to nylon. Nonionic detergents are produced by alkylation of ...
216 CYCLOHEXANONE ICSC: 0425 MSDS Cyclopentadiene Yaws, Carl L.; Braker, William; Matheson Gas Data Book Published by McGraw- ...
Meyers, A. I.; Williams, D. R.; Druelinger, M. (1976). "Enantioselective alkylation of cyclohexanone via chiral lithio-chelated ...
Another application is the rearrangement of cyclohexanone oxime to caprolactam. Many alkylamines are prepared by amination of ...
Cyclohexanone is obtained by Birch reduction followed by acid hydrolysis. It can be obtained from cyclohexanone by α- ...
NOCl and cyclohexane react photochemically to give cyclohexanone oxime hydrochloride. This process exploits the tendency of ...
Another major application is the rearrangement of cyclohexanone oxime to caprolactam. Many alkylamines are prepared by ...
It can be prepared by oxidation of cyclohexanone by selenium dioxide. Numerous diimine and dioxime ligands have been prepared ...
Other cyclic ketones: Cyclopropanone Cyclopentanone Cyclohexanone CRC Handbook of Chemistry and Physics. 90. Boca Raton, FL: ...
"A synthesis of vitamin a from cyclohexanone", J. Chem. Soc.: 1094-1111, doi:10.1039/JR9520001094 . Leo A. Paquette and Todd M. ...
An example is the trifluoromethylation of cyclohexanone in THF using tetrabutylammonium fluoride. The substrates can be aryl ...
... such as the Henbest Catalyst for transfer hydrogenation of cyclohexanones. Thomas R. B. Mitchell (2001). "Iridium(IV) Chloride ...
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations ...
Required Elements for Initial Public Posting. Subject: NIOSH Skin Notation Profile. Purpose: Provides information about the health risks associated with dermal contact and uptake of a specific workplace chemical.. Timing of Review: March 2019 - May 2019.. Primary Disciplines or Expertise Needed for Review: Toxicology, risk assessment, industrial hygiene, occupational medicine.. Type of Review: Individual. Number of Reviewers: 2-3 reviewers. Reviewers Selected by: NIOSH. Public Nominations Requested for Reviewers: No. Opportunities for the Public to Comment: Yes. Peer Reviewers Provided with Public Comments Before Their Review: No. Charge to Peer Reviewers. Reviewers are asked to consider the following review questions:. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Kozyro, A.A.; Sheiman, M.S.; Kabo, G.Ya.; Yursha, I.A.; Kruk, V.S., Heat capacity and thermodynamic properties of cyclohexanone ... Kozyro, A.A.; Marachuk, L.I.; Krasulin, A.P.; Yursha, I.A.; Kabo, G.Ya., Thermodynamic properties of cyclohexanone oxime and « ... Thermodynamic properties of cyclohexanone oxime, J. Chem. Thermodyn., 1992, 24, 883-895. [all data] ...
Cyclohexanone Sigma-Aldrich Co., Cyclohexanone. Retrieved on 2017-11-20. "Cyclohexanone". Immediately Dangerous to Life and ... The other half of the cyclohexanone supply is converted to cyclohexanone oxime. In the presence of sulfuric acid catalyst, the ... Over time, samples of cyclohexanone assume a yellow color. Cyclohexanone is slightly soluble in water and miscible with common ... Like cyclohexanol, cyclohexanone is not carcinogenic and is only moderately toxic, with a TLV of 25 ppm for the vapor. It is an ...
Cyclohexanone oxime can be prepared from the condensation reaction between cyclohexanone and hydroxylamine: C5H10CO + H2NOH → ... Cyclohexanone oxime is an organic compound containing the functional group oxime. This colorless solid is an important ... It can also be hydrolyzed with acetic acid to give back cyclohexanone. J. C. Eck and C. S. Marvel "ε-Benzoylaminocaproic Acid" ... This method is advantageous as cyclohexane is much cheaper than cyclohexanone. The most famous and commercially important ...
... cyclohexanone 0.98; CAS Number: 52190-35-9; Linear Formula: CH3SC6H9(=O); find related products, papers, technical documents, ... ne is a 2-substituted cyclohexanone. The proportion of axial and equatorial conformation has been measured in chloroform by the ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
An OECD guideline study (404) showed after an exposure period of 3 hours slight to moderate erythema as well as slight edema. After an exposure period of 1 h our slight to marked erythema and after 4 hours slight to moderate erythema were observed. In an EpiDerm test in vitro a corrosive potential of the test substance was seen (BASF, 2003). An in vitro eye irritation test (HET-CAM) showed serious eye damage (BASF, 2006). This was in concordance with an older BASF in vivo study (1966), where severe irritating eye effects were found. ...
The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... Kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a. Bag type copper-alloy catalyst. ...
Cyclohexanone is used as an industrial solvent and paint remover. It acts as a precursor to nylon 6,6 and nylon 6 and ... Zhang, J.; Dong, C.; Du, C.; Luo, G. Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System. ... Patil, R. D.; Sasson, Y. Selective transfer hydrogenation of phenol to cyclohexanone on supported palladium catalyst using ... cyclohexanone oxime, which gives caprolactam on rearrangement. Further, it is used as a chemical reaction medium, adhesives, ...
SBA-15 Cyclohexanol Dehydrogenation Cyclohexanone Electronic supplementary material. The online version of this article ( https ... Copper oxide modified SBA-15 for the selective vapour phase dehydrogenation of cyclohexanol to cyclohexanone. ...
4-trans-4-propylcyclohexyl cyclohexanone, 4-4-propylcyclohexyl cyclohexanone, 4-propyldicyclohexylanone, 4-trans-4-n- ... 4-trans-4-propylcyclohexyl cyclohexanone, 4-4-propylcyclohexyl cyclohexanone, 4-propyldicyclohexylanone, 4-trans-4-n- ... propylcyclohexyl-cyclohexanone, 4-4-propylcyclohexyl cyclohexan-1-one, 4-trans-4-propylcyclohexyl cyclohexanone, 4-propyl-1,1 ... propylcyclohexyl-cyclohexanone, 4-4-propylcyclohexyl cyclohexan-1-one, 4-trans-4-propylcyclohexyl cyclohexanone, 4-propyl-1,1 ...
Product name: CYCLOHEXANONE Batch Number 20161008 Manu.date 2016.10.08 standaard Index Specification Result Chrominance ≤15 10 ...
The Global Cyclohexanone Peroxide Market Report provides a basic overview of the Global Cyclohexanone Peroxide including ... Global Cyclohexanone Peroxide Forecast 2017-2022. *Global Cyclohexanone Peroxide Capacity, Production, Revenue Forecast 2017- ... Global Cyclohexanone Peroxide Production Forecast by Type 2017-2022. *Global Cyclohexanone Peroxide Consumption Forecast by ... Global Cyclohexanone Peroxide Market report is a professional and in-depth study on the current state of the Global ...
Cyclohexanone 2,4-dinitrophenylhydrazone is a useful standard for elemental analysis. Also used as a pharmaceutical ... Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4- ...
Cyclohexanone Chemicals, Cyclohexene Chemicals, Heptanesulfonic Acid Sodium Salt Anhydrous and Diethylamine Chemicals offered ... Offering you a complete choice of products which include Cyclohexane Chemicals, Cyclohexanone Chemicals, Cyclohexene Chemicals ... we are able to supply an extensive array of high-quality Cyclohexanone Chemicals to our customers which is an organic compound ... cyclohexanone and as fuel for camp stoves. Features:. *Well-packed ...
... cyclohexanone, examines its uses, production methods, patents. 4,4-(Ethylenedioxy)cyclohexanone market ... Cyclohexanone Markets in China US$ 4,000.00 Apr, 2017 · 193 pages Cyclohexanone Market Research US$ 2,770.00 Apr, 2009 · 124 ... 4,4-(ethylenedioxy)cyclohexanone prices in other regions. 7. 4,4-(ETHYLENEDIOXY)CYCLOHEXANONE END-USE SECTOR 7.1. 4,4-( ... 4,4-(ethylenedioxy)cyclohexanone market forecast. 6. 4,4-(ETHYLENEDIOXY)CYCLOHEXANONE MARKET PRICES. 6.1. 4,4-(ethylenedioxy) ...
Ionones and Cyclohexanone Group Public Comment Summary July 2019 Résumé des commentaires du public sur lébauche dévaluation ... préalable du groupe des lactones et cétones macrocycliques, des ionones et de la cyclohexanone Juillet 2019 ... Comments on the draft assessment for the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group to be addressed as ... Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group Public Comment Summary Official Title: Macrocyclic Lactones ...
... selectivity to cyclohexanone using hydrogen peroxide as an oxidant and WO3 as a catalyst. The effect of the IL as a solvent is ... cyclohexanone. using hydrogen peroxide. as an oxidant and WO3 as a catalyst. . The effect of the IL as a solvent. is discussed ... cyclohexanone. in the ionic liquid. 1-octyl-3-methylimidazolium chloride. L. Chen, T. Zhou, L. Chen, Y. Ye, Z. Qi, H. Freund ... Selective oxidation of cyclohexanol to cyclohexanone in the ionic liquid1-octyl-3-methylimidazolium chloride ...
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Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Message Subject (Your Name) has forwarded a page to you ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ... Metabolism and disposition of cyclohexanone oxime in male F-344 rats.. D Parmar and L T Burka ...
4-N-acetyl-amino-cyclohexanone Molecular formula:C8H13NO2 Molecular weight:155.19 CAS:27514-08-5 Properties:Light yellow or off ... to white powder; MP:114~118ºC; lose on drying:less than1.0%; heavy - 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5 Details. ... 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5. Home / Chemicals / Organic Chemical Materials / 4-N-acetyl-amino-cyclohexanone, ... Detailed 4-N-acetyl-amino-cyclohexanone,CAS 27514-08-5 Description:. Name: 4-N-acetyl-amino-cyclohexanone. Molecular formula: ...
Cu(II)-catalysed Oxidation of Cyclohexanone & Lactic Acid by Vanadium(V) in Hel Medium. ...
  • Comments on the draft assessment for the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group to be addressed as part of the Chemicals Management Plan were submitted. (canada.ca)
  • Maximal enzyme activity was measured at pH 9 and 35°C. MMKMO has a broad substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones. (tudelft.nl)
  • Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4-dinitrophenylhydrazine-coated solid sorbent. (alfa.com)
  • These products are used in the production of caprolactam, nylon intermediate and as a solvent for lacquers and resins, as a paint and varnish remover, as intermediate in the manufacture of benzene, cyclohexanone and as fuel for camp stoves. (indiamart.com)
  • More specifically, the two acrylic polymers and the aldehyde resin were found highly stable with regard to their molecular condition, as compared to the cyclohexanone-based polymer, while all four polymers displayed changes in their colour and film thickness. (benakiconservation.com)
  • When cyclohexanone was used as the extraction solvent at 120 °C in 3 min, 95% of the PHB was recovered from the cells with a similar purity to that extracted using chloroform. (mdpi.com)
  • Sasson, Y. Selective transfer hydrogenation of phenol to cyclohexanone on supported palladium catalyst using potassium formate as hydrogen source under open atmosphere. (alfa.com)
  • The combination of trifluoroacetic acid (TFA), tert -butyl hydroperoxide (TBHP), dimethylsulfoxide (DMSO) and oxygen (O 2 ) converted the cyclohexanone derivatives to an aromatic aryl product in moderate to good yields. (wordpress.com)
  • Aromatic aldehydes react with dimethyl acetonedicarboxylate in molar ratio 1:2 with spontaneous intramolecular Michael addition to give polysubstituted cyclohexanones . (mdpi.com)
  • In acute studies, cyclohexanone had a moderate to low toxicity by the oral route in rats and mice and was moderately toxic by inhalation in rats and when applied to the skin of rabbits. (bibra-information.co.uk)
  • We previously showed that 2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC), suppressed the synthesis of various proinflammatory mediators. (upm.edu.my)
  • CYCLOHEXANONE (C 6 H 10 O) is an intermediate product of the Caprolactam Plant. (gsfclimited.com)
  • The intermediate cyclohexanecarbonitrile can be prepared from the bisulfite addition product of cyclohexanone by treatment with KCN and piperidine 6 , or by the addition of cyclohexanone and KCN to an aqueous solution of piperidine hydrochloride 7 . (erowid.org)
  • Analogs of PCP with a mono- substituent on the nitrogen are best prepared through the Schiff base intermediate (6) formed from cyclohexanone and the appropriate primary amine 6 . (erowid.org)
  • 4,4-(ethylenedioxy)cyclohexanone manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • Here, we report two crystal structures of cyclohexanone monooxygenase (CHMO) with its product, ε-caprolactone, bound: the CHMOTight and CHMOLoose structures. (canada.ca)
  • The Global Cyclohexanone Peroxide Market Report provides a basic overview of the Global Cyclohexanone Peroxide including definitions, classifications, applications and chain structure. (beforeitsnews.com)
  • To begin with, the report elaborates Global Cyclohexanone Peroxide overview, Various definitions and classification of the industry, applications of industry and chain structure are given. (beforeitsnews.com)
  • The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice. (upm.edu.my)
  • In a nutshell, cyclohexanone in particular was identified as an expedient candidate to efficiently drive novel, sustainable PHA extraction processes. (mdpi.com)
  • Cyclohexanone has been used in the illicit production of phencyclidine and its analogues and as such is often subject to additional checks before purchase. (wikipedia.org)
  • After the basic information, the Global Cyclohexanone Peroxide Industry report sheds light on the production, production plants, their capacities, global production and revenue are studied. (beforeitsnews.com)