Cyclohexanols
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Potassium Dichromate
Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.
Todralazine
Caustics
Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.
Chromium
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Cyclohexylamines
Transition Temperature
Nickel
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Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
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Neuromuscular Depolarizing Agents
Phencyclidine
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The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. (1/579)
Upon activation, brain microglial cells release proinflammatory mediators, such as nitric oxide (NO), which may play an important role in the central nervous system antibacterial, antiviral, and antitumor activities. However, excessive release of NO has been postulated to elicit immune-mediated neurodegenerative inflammatory processes and to cause brain injury. In the present study, the effect of cannabinoids on the release of NO from endotoxin/cytokine-activated rat cortical microglial cells was evaluated. A drug dose-dependent (0.1 microM-8 microM) inhibition of NO release from rat microglial cells was exerted by the cannabinoid receptor high-affinity binding enantiomer (-)-CP55940. In contrast, a minimal inhibitory effect was exerted by the lower affinity binding paired enantiomer (+)-CP56667. Pretreatment of microglial cells with the Galphai/Galphao protein inactivator pertussis toxin, cyclic AMP reconstitution with the cell-permeable analog dibutyryl-cAMP, or treatment of cells with the Galphas activator cholera toxin, resulted in reversal of the (-)-CP55940-mediated inhibition of NO release. A similar reversal in (-)-CP55940-mediated inhibition of NO release was effected when microglial cells were pretreated with the central cannabinoid receptor (CB1) selective antagonist SR141716A. Mutagenic reverse transcription-polymerase chain reaction, Western immunoblot assay using a CB1 receptor amine terminal domain-specific antibody, and cellular colocalization of CB1 and the microglial marker Griffonia simplicifolia isolectin B4 confirmed the expression of the CB1 receptor in rat microglial cells. Collectively, these results indicate a functional linkage between the CB1 receptor and cannabinoid-mediated inhibition of NO production by rat microglial cells. (+info)Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. (2/579)
The effects of cannabinoid agonists on noxious heat-evoked firing of 62 spinal wide dynamic range (WDR) neurons were examined in urethan-anesthetized rats (1 cell/animal). Noxious thermal stimulation was applied with a Peltier device to the receptive fields in the ipsilateral hindpaw of isolated WDR neurons. To assess the site of action, cannabinoids were administered systemically in intact and spinally transected rats and intraventricularly. Both the aminoalkylindole cannabinoid WIN55,212-2 (125 microg/kg iv) and the bicyclic cannabinoid CP55,940 (125 microg/kg iv) suppressed noxious heat-evoked activity. Responses evoked by mild pressure in nonnociceptive neurons were not altered by CP55,940 (125 microg/kg iv), consistent with previous observations with another cannabinoid agonist, WIN55,212-2. The cannabinoid induced-suppression of noxious heat-evoked activity was blocked by pretreatment with SR141716A (1 mg/kg iv), a competitive antagonist for central cannabinoid CB1 receptors. By contrast, intravenous administration of either vehicle or the receptor-inactive enantiomer WIN55,212-3 (125 microg/kg) failed to alter noxious heat-evoked activity. The suppression of noxious heat-evoked activity induced by WIN55,212-2 in the lumbar dorsal horn of intact animals was markedly attenuated in spinal rats. Moreover, intraventricular administration of WIN55,212-2 suppressed noxious heat-evoked activity in spinal WDR neurons. By contrast, both vehicle and enantiomer were inactive. These findings suggest that cannabinoids selectively modulate the activity of nociceptive neurons in the spinal dorsal horn by actions at CB1 receptors. This modulation represents a suppression of pain neurotransmission because the inhibitory effects are selective for pain-sensitive neurons and are observed with different modalities of noxious stimulation. The data also provide converging lines of evidence for a role for descending antinociceptive mechanisms in cannabinoid modulation of spinal nociceptive processing. (+info)Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. (3/579)
The human cannabinoid receptors, central cannabinoid receptor (CB1) and peripheral cannabinoid receptor (CB2), share only 44% amino acid identity overall, yet most ligands do not discriminate between receptor subtypes. Site-directed mutagenesis was employed as a means of mapping the ligand recognition site for the human CB2 cannabinoid receptor. A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function. The analogous mutation in the CB1 receptor (K192A) was found to be crucial for recognition of several cannabinoid compounds excluding (R)-(+)-[2, 3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-6-yl](1-naphthalenyl)methanone (WIN 55,212-2). In contrast, in human embryonic kidney (HEK)-293 cells expressing the mutant or wild-type CB2 receptors, we found no significant differences in either the binding profile of several cannabinoid ligands nor in inhibition of cAMP accumulation. We identified a high-affinity site for (-)-3-[2-hydroxyl-4-(1, 1-dimethylheptyl)phenyl]-4-[3-hydroxyl propyl] cyclohexan-1-ol (CP-55,940) in the region of helices 3, 6, and 7, with S3.31(112), T3.35(116), and N7.49(295) in the K109A mutant using molecular modeling. The serine residue, unique to the CB2 receptor, was then mutated to glycine in the K109A mutant. This double mutant, K109AS112G, retains the ability to bind aminoalkylindoles but loses affinity for classical cannabinoids, as predicted by the molecular model. Distinct cellular localization of the mutant receptors observed with immunofluorescence also suggests differences in receptor function. In summary, we identified amino acid residues in the CB2 receptor that could lead to subtype specificity. (+info)Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. (4/579)
1. The aim of the present study was to analyse the cardiovascular actions of the synthetic CB1/CB2 cannabinoid receptor agonist WIN55212-2, and specifically to determine its sites of action on sympathetic cardiovascular regulation. 2. Pithed rabbits in which the sympathetic outflow was continuously stimulated electrically or which received a pressor infusion of noradrenaline were used to study peripheral prejunctional and direct vascular effects, respectively. For studying effects on brain stem cardiovascular regulatory centres, drugs were administered into the cisterna cerebellomedullaris in conscious rabbits. Overall cardiovascular effects of the cannabinoid were studied in conscious rabbits with intravenous drug administration. 3. In pithed rabbits in which the sympathetic outflow was continuously electrically stimulated, intravenous injection of WIN55212-2 (5, 50 and 500 microg kg(-1)) markedly reduced blood pressure, the spillover of noradrenaline into plasma and the plasma noradrenaline concentration, and these effects were antagonized by the CB1 cannabinoid receptor-selective antagonist SR141716A. The hypotensive and the sympathoinhibitory effect of WIN55212-2 was shared by CP55940, another mixed CB1/CB2 cannabinoid receptor agonist, but not by WIN55212-3, the enantiomer of WIN55212-2, which lacks affinity for cannabinoid binding sites. WIN55212-2 had no effect on vascular tone established by infusion of noradrenaline in pithed rabbits. 4. Intracisternal application of WIN55212-2 (0.1, 1 and 10 microg kg(-1)) in conscious rabbits increased blood pressure and the plasma noradrenaline concentration and elicited bradycardia; this latter effect was antagonized by atropine. 5. In conscious animals, intravenous injection of WIN55212-2 (5 and 50 microg kg(-1)) caused bradycardia, slight hypotension, no change in the plasma noradrenaline concentration, and an increase in renal sympathetic nerve firing. The highest dose of WIN55212-2 (500 microg kg(-1)) elicited hypotension and tachycardia, and sympathetic nerve activity and the plasma noradrenaline concentration declined. 6. The results obtained in pithed rabbits indicate that activation of CB1 cannabinoid receptors leads to marked peripheral prejunctional inhibition of noradrenaline release from postganglionic sympathetic axons. Intracisternal application of WIN55212-2 uncovered two effects on brain stem cardiovascular centres: sympathoexcitation and activation of cardiac vagal fibres. The highest dose of systemically administered WIN55212-2 produced central sympathoinhibition; the primary site of this action is not known. (+info)Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. (5/579)
We have tested our prediction that AM630 is a CB2 cannabinoid receptor ligand and also investigated whether L759633 and L759656, are CB2 receptor agonists. Binding assays with membranes from CHO cells stably transfected with human CB1 or CB2 receptors using [3H]-CP55940, confirmed the CB2-selectivity of L759633 and L759656 (CB2/CB1 affinity ratios = 163 and 414 respectively) and showed AM630 to have a Ki at CB2 receptors of 31.2 nM and a CB2/CB1 affinity ratio of 165. In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. AM630 inhibited [35S]-GTPgammaS binding to CB2 receptor membranes (EC50 = 76.6 nM), enhanced forskolin-stimulated cyclic AMP production in CB2-transfected cells (5.2 fold by 1 microM), and antagonized the inhibition of forskolin-stimulated cyclic AMP production in this cell line induced by CP55940. In CB1-transfected cells, forskolin-stimulated cyclic AMP production was significantly inhibited by AM630 (22.6% at 1 microM and 45.9% at 10 microM) and by L759633 at 10 microM (48%) but not 1 microM. L759656 (10 microM) was not inhibitory. AM630 also produced a slight decrease in the mean inhibitory effect of CP55940 on cyclic AMP production which was not statistically significant. We conclude that AM630 is a CB2-selective ligand that behaves as an inverse agonist at CB2 receptors and as a weak partial agonist at CB1 receptors. L759633 and L759656 are both potent CB2-selective agonists. (+info)O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. (6/579)
The biotransformation of venlafaxine (VF) into its two major metabolites, O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) was studied in vitro with human liver microsomes and with microsomes containing individual human cytochromes from cDNA-transfected human lymphoblastoid cells. VF was coincubated with selective cytochrome P450 (CYP) inhibitors and several selective serotonin reuptake inhibitors (SSRIs) to assess their inhibitory effect on VF metabolism. Formation rates for ODV incubated with human microsomes were consistent with Michaelis-Menten kinetics for a single-enzyme mediated reaction with substrate inhibition. Mean parameters determined by non-linear regression were: Vmax = 0.36 nmol/min/mg protein, K(m) = 41 microM, and Ks 22901 microM (Ks represents a constant which reflects the degree of substrate inhibition). Quinidine (QUI) was a potent inhibitor of ODV formation with a Ki of 0.04 microM, and paroxetine (PX) was the most potent SSRI at inhibiting ODV formation with a mean Ki value of 0.17 microM. Studies using expressed cytochromes showed that ODV was formed by CYP2C9, -2C19, and -2D6. CYP2D6 was dominant with the lowest K(m), 23.2 microM, and highest intrinsic clearance (Vmax/K(m) ratio). No unique model was applicable to the formation of NDV for all four livers tested. Parameters determined by applying a single-enzyme model were Vmax = 2.14 nmol/min/mg protein, and K(m) = 2504 microM. Ketoconazole was a potent inhibitor of NDV production, although its inhibitory activity was not as great as observed with pure 3A substrates. NDV formation was also reduced by 42% by a polyclonal rabbit antibody against rat liver CYP3A1. Studies using expressed cytochromes showed that NDV was formed by CYP2C9, -2C19, and -3A4. The highest intrinsic clearance was attributable to CYP2C19 and the lowest to CYP3A4. However the high in vivo abundance of 3A isoforms will magnify the importance of this cytochrome. Fluvoxamine (FX), at a concentration of 20 microM, decreased NDV production by 46% consistent with the capacity of FX to inhibit CYP3A, 2C9, and 2C19. These results are consistent with previous studies that show CYP2D6 and -3A4 play important roles in the formation of ODV and NDV, respectively. In addition we have shown that several other CYPs have important roles in the biotransformation of VF. (+info)Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. (7/579)
Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2). These genomic modulations observed on large-scale cDNA arrays were first confirmed by Northern blot studies. Furthermore, ELISA evaluations in culture supernatants indicated that the cannabinoid-induced activation of these two chemokine genes was followed by enhanced expression and secretion of the corresponding proteins. These upregulations initially observed in transfected HL60 cells overexpressing CB2 receptors, also occurred in normal non-transfected HL60 cells. The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors. More specifically, the abolition of the cannabinoid-induced effect by the specific CB2 antagonist SR 144528 indicated a strict peripheral cannabinoid-mediated process. Altogether, our data highlight a possible new function of peripheral cannabinoid receptors in the modulation of immune and inflammatory responses. (+info)Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways. (8/579)
We previously showed that the cannabinoid receptor CB1 stably transfected in Chinese hamster ovary cells was constitutively active and could be inhibited by the inverse agonist SR 141716A. In the present study, we demonstrate that the cannabinoid agonist CP-55940 induced cytosol alkalinization of CHO-CB1 cells in a dose- and time-dependent manner via activation of the Na+/H+ exchanger NHE-1 isoform. By contrast, the inverse agonist SR 141716A induced acidification of the cell cytosol, suggesting that the Na+/H+ exchanger NHE-1 was constitutively activated by the CB1 receptor. CB1-mediated NHE1 activation was prevented by both pertussis toxin treatment and the specific MAP kinase inhibitor PD98059. NHE-1 and p42/p44 MAPK had a similar time course of activation in response to the addition of CP-55940 to CHO-CB1 cells. These results suggest that CB1 stimulates NHE-1 by G(i/o)-mediated activation of p42/p44 MAP kinase and highlight a cellular physiological process targeted by CB1. (+info)
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Alcohol
cyclohexanol isobutyl alcohol,. 2-methylpropan-1-ol, or. 2-methyl-1-propanol tert-amyl alcohol,. 2-methylbutan-2-ol, or. 2- ...
Friedel-Crafts reaction
Cyclohexanol (C. 6). *2-Heptanol (C. 7). *3-Heptanol (C. 7). *2-Octanol (C. 8) ...
Isopropyl alcohol
Cyclohexanol (C. 6). *2-Octanol (C. 8). Tertiary. alcohols (3°). *tert-Butyl alcohol (C. 4) ...
Cyclohexene
"Cyclohexanol, method for producing cyclohexanol, and method for producing adipic acid" Plotkin, Jeffrey S. (2016-03-21). " ... Hydration of cyclohexene gives cyclohexanol, which can be dehydrogenated to give cyclohexanone, a precursor to caprolactam. The ... Musser, Michael T. (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ...
Cyclohexane
The cyclohexanone-cyclohexanol mixture, called "KA oil", is a raw material for adipic acid and caprolactam, precursors to nylon ... Several million kilograms of cyclohexanone and cyclohexanol are produced annually. It is used as a solvent in some brands of ... Michael Tuttle Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley ... Although rather unreactive, cyclohexane undergoes catalytic oxidation to produce cyclohexanone and cyclohexanol. ...
Hydroperoxide
Michael T. Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH ...
Trifluoromethyltrimethylsilane
Pichika Ramaiah; Ramesh Krishnamurt; G. K. Surya Prakash (1995). "1-Trifluoromethyl-1-cyclohexanol". Org. Synth. 72: 232. doi: ...
Organofluorine chemistry
Pichika Ramaiah, Ramesh Krishnamurti, and G. K. Surya Prakash (1998). "1-trifluoromethyl)-1-cyclohexanol". Organic Syntheses: ...
6-oxohexanoate dehydrogenase
Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ...
Alicycliphilus
nov., a cyclohexanol-degrading, nitrate-reducing beta-proteobacterium". International Journal of Systematic and Evolutionary ...
Cometabolism
Accidentally, this enzyme also oxidizes, at no additional cost for M. vaccae, cyclohexane into cyclohexanol. Thus, cyclohexane ... The latter can metabolize cyclohexanol, but not cyclohexane. Some of the molecules that are cometabolically degraded by ...
Cyclohexyl nitrite
It is the ester of cyclohexanol and nitrous acid. It is an alkyl nitrite like amyl nitrite and butyl nitrite. It acts as an ...
PCHP
4-Phenyl-4-(1-piperidinyl)cyclohexanol, another PCP metabolite Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Fukaya, Hiroaki; ...
Trimethylsilyl iodide
Cyclohexanol from Cyclohexyl Methyl Ether". Organic Syntheses.; Collective Volume, 6, p. 353 "GC/MS Analysis for Morphine and ...
Cyclohexyl chloride
... can be prepared from cyclohexanol by treatment with hydrogen chloride. Henry Gilman and W. E. Catlin (1926 ...
Cyclohexane-1,3-dione hydrolase
Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ...
3-hydroxycyclohexanone dehydrogenase
Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ...
BDPC
... (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent ... "4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use", issued 1982-12-28, assigned to Upjohn company ...
Hydroxymethylation
Cyclohexanol from Cyclohexanone". Organic Syntheses. 69: 96. doi:10.15227/orgsyn.069.0096. M. Caporali, L. Gonsalvi, F. ...
Cyclohexanone
Like cyclohexanol, cyclohexanone is not carcinogenic and is moderately toxic, with a TLV of 25 ppm for the vapor. It is an ... In some cases, purified cyclohexanol, obtained by hydration of cyclohexene, is the precursor. Alternatively, cyclohexanone can ... Cyclohexanone can be prepared from cyclohexanol by oxidation with chromium trioxide (Jones oxidation). An alternative method ... H2O This process co-forms cyclohexanol, and this mixture, called "KA Oil" for ketone-alcohol oil, is the main feedstock for the ...
A value
The trans compound had rates identical to those found in the monosubstituted cyclohexanol. Using the A-Values of the hydroxyl ...
Adipic acid
... is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of ketone-alcohol oil ... Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid: HOC6H11 + HNO3 → OC(CH2)5 + HNO2 + ... Related processes start from cyclohexanol, which is obtained from the hydrogenation of phenol. Several methods have been ...
Ojima lactam
The acid chloride reacts with the chiral auxiliary trans-2-phenyl-1-cyclohexanol. The benzyl group is then removed and replaced ...
Diethyl azodicarboxylate
Similarly, reacting DEAD with ethanol and cyclohexanol abstracts hydrogen producing acetaldehyde and cyclohexanone. Those ...
C-8813
trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol ...
Lofepramine
... an ethyl cyclohexanol derivative". Biochem. Pharmacol. 35 (24): 4493-7. doi:10.1016/0006-2952(86)90769-0. PMID 3790168. Sánchez ...
Dehydration reaction
"Dehydration of 2-Methyl-1-cyclohexanol: New Findings from a Popular Undergraduate Laboratory Experiment". J. Chem. Educ. 88 (8 ...
Chiral auxiliary
... such as trans-2-phenyl-1-cyclohexanol and trans-2-(1-pheyl-1-methylethyl)cyclohexanol have been explored. 1,1'-Binaphthyl-2,2'- ... The menthol compound is difficult to prepare and as an alternative trans-2-phenyl-1-cyclohexanol was introduced by J. K. ... Synthetic strategies for setting a key stereocenter in atorvastatin Example of use of trans-2-phenyl-1-cyclohexanol as chiral ... Comins, D. L.; Salvador, J. D. (1993). "Efficient Synthesis and Resolution of trans-2-(1-Aryl-1-methylethyl)cyclohexanols: ...
Tramadol
Thus, 2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol may exist in four different configurational forms: (1R,2R)-isomer ... Tramadol [2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol] has two stereogenic centers at the cyclohexane ring. ...
Thermoresponsive polymers in chromatography
Cyclohexanol acted as a successful porogen showing a dependent relationship of pore size to temperature. The use of toluene as ... The in-situ preparation compared the use of cyclohexanol and toluene as porogens in the preparation of the modified polystyrene ...
ICSC 0243 - CYCLOHEXANOL
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water ...
NIOSH Skin Notation Profile: Cyclohexanol | NIOSH | CDC
NIOSH [2020]. NIOSH skin notation profile: cyclohexanol. By Hudson NL. Cincinnati, OH: U.S. Department of Health and Human ... This Skin Notation Profile provides the SK assignments and supportive data for cyclohexanol. In particular, this document ... NIOSH Skin Notation Profile Cyclohexanol 2021-101 pdf icon[PDF - 403 KB] ...
Cyclohexanol
Cyclohexanol, 2-mercapto
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Cyclohexanol - Wikipedia
Cyclohexanol has at least two solid phases. One of them is a plastic crystal. As indicated above, cyclohexanol is an important ... Cyclohexanol is somewhat toxic: the TLV for the vapor for 8 h is 50 ppm. The IDLH concentration is set at 400 ppm, based on ... Cyclohexanol is the organic compound with the formula HOCH(CH2)5. The molecule is related to cyclohexane by replacement of one ... Alternatively, cyclohexanol can be produced by the hydrogenation of phenol: C6H5OH + 3 H2 → C6H11OH This process can also be ...
Cyclohexanol dehydrogenase - Wikipedia
In enzymology, a cyclohexanol dehydrogenase (EC 1.1.1.245) is an enzyme that catalyzes the chemical reaction cyclohexanol + ... Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ... Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ... The systematic name of this enzyme class is cyclohexanol:NAD+ oxidoreductase. This enzyme participates in caprolactam ...
Cyclohexanol - Registration Dossier - ECHA
ENGINEERING MEASURES Containment and/or segregation is the most reliable technical protection measures if exposure cannot be eliminated. The extent of these protection measures depends on the actual risks in use. If airborne mists or vapors are generated, use local exhaust ventilation controls. Assess exposure and use any additional measures to keep airborne levels below any relevant exposure limit. Where necessary, seek additional occupational hygiene advice. PERSONAL PROTECTIVE EQUIPMENTProtective measuresThe use of technical measures should always have priority over the use of personal protective equipment. When selecting personal protective equipment, seek appropriate professional advice. Personal protective equipment should be certified to appropriate standards.Respiratory protectionA combination gas, vapor and particulate respirator may be necessary until effective technical measures are installed.Protection provided by air-purifying respirators is limited.Use a self-contained breathing ...
Methyl cyclohexanol | C7H14O | ChemSpider
A microscale oxidation of cyclohexanol by potassium dichromate(VI)- Learn Chemistry
A few drops of cyclohexanol is added and a clear reaction is observed for the formation of cyclohexanone. ... Cyclohexanol, C6H11OH(s) or (l) (HARMFUL) - see CLEAPSS Hazcard. Cyclohexanol has a melting point of 20 - 22°C (about room ... cyclohexanol. are added to the pool. There are clear signs of reaction as the cyclohexanone. is formed.. ... In cold laboratories, warm the cyclohexanol first!. Potassium dichromate(VI), K2Cr2O7(s), (OXIDISING, VERY TOXIC, DANGEROUS FOR ...
Diffusion coefficient of cyclohexanol in hexan-1-ol at infinite dilution | SpringerLink
This chapter provides the diffusion coefficient of cyclohexanol in hexan-1-ol at infinite dilution for various temperature and ... This chapter provides the diffusion coefficient of cyclohexanol in hexan-1-ol at infinite dilution for various temperature and ... Winkelmann J. (2018) Diffusion coefficient of cyclohexanol in hexan-1-ol at infinite dilution. In: Lechner M.D. (eds) Diffusion ...
Cyclohexanol - MP Biomedicals
4-Alkyl Substituted Cyclohexanols | Organic Chemicals | Spectrum Chemical
Kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a. Bag type copper-alloy catalyst | SpringerLink
The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. A kinetic ... Kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a. Bag type copper-alloy catalyst. ...
1-METHYL-3-(2-METHYLPROPYL)CYCLOHEXANOL - Substance Information - ECHA
Enzyme reactions involved in anaerobic cyclohexanol metabolism by a denitrifying Pseudomonas species
The enzymes involved in the anaerobic degradation of cyclohexanol were searched for in a denitrifying Pseudomonas species which ... Enzyme reactions involved in anaerobic cyclohexanol metabolism by a denitrifying Pseudomonas species Arch Microbiol. 1989;152(3 ... Cyclohexanol dehydrogenase catalyzes the oxidation of the substrate to cyclohexanone. Cyclohexanone dehydrogenase oxidizes ... The enzymes involved in the anaerobic degradation of cyclohexanol were searched for in a denitrifying Pseudomonas species which ...
Dehydration Of Cyclohexanol - 861 Words | AntiEssays
Conclusion In this experiment we learned how to synthesize the cyclohexene by dehydration of cyclohexanol. We procedure the ... 1- Cyclohexanol dehydrated by sulfuric acid to produce cyclohexene) Procedure: 1. Mix five mL of Cyclohexanol and 2.5 mL of 9M ... Cyclohexanone From Cyclohexanol By Hypochlorite Ox. 953 Words , 4 Pages. *. Simple and Fractional Distillation of a Binary ... Cyclohexanone From Cyclohexanol By Hypochlorite Ox. 953 Words , 4 Pages. Therefore, acetic acid was used for this experiment. ...
Synthesis and purification of (r*,r*)-2-&lsqb (dimethylamino) methyl&rsqb -1-(3-methoxyphenyl) cyclohexanol hydrochloride -...
R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the ... Synthesis and purification of (r*,r*)-2-&lsqb (dimethylamino) methyl&rsqb -1-(3-methoxyphenyl) cyclohexanol hydrochloride ... Process for the purification of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol and its salts. 1995-05-09. Cherkez et ... R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the ...
Catalysts | Free Full-Text | Nickel Catalyzed Conversion of Cyclohexanol into Cyclohexylamine in Water and Low Boiling Point...
Nickel is found to demonstrate high performance in the amination of cyclohexanol into cyclohexylamine in water and two solvents ... Keywords: nickel; cyclohexanol; cyclohexylamine; base; hydrogen nickel; cyclohexanol; cyclohexylamine; base; hydrogen ►▼ ... Qi Y, Yu H, Cao Q, Dong B, Mu X, Mao A. Nickel Catalyzed Conversion of Cyclohexanol into Cyclohexylamine in Water and Low ... Qi, Y.; Yu, H.; Cao, Q.; Dong, B.; Mu, X.; Mao, A. Nickel Catalyzed Conversion of Cyclohexanol into Cyclohexylamine in Water ...
Diffusion coefficient of cyclohexanol in methanol at infinite dilution | Springer for Research & Development
This chapter provides the diffusion coefficient of cyclohexanol in methanol at infinite dilution for various temperature and ... Winkelmann J. (2018) Diffusion coefficient of cyclohexanol in methanol at infinite dilution. In: Lechner M.D. (eds) Diffusion ... This chapter provides the diffusion coefficient of cyclohexanol in methanol at infinite dilution for various temperature and ...
1r,4r)-4-(dibenzylamino)cyclohexanol (CAS No. 149506-81-0) Suppliers @ ChemicalRegister.com
1r,4r)-4-(dibenzylamino)cyclohexanol (CAS No. 149506-81-0) Suppliers. EMAIL INQUIRY to 5 suppliers ... EMAIL INQUIRY to 5 (1r,4r)-4-(dibenzylamino)cyclohexanol (CAS No. 149506-81-0) suppliers ... Synonyms: Cyclohexanol, 4-[bis(phenylmethyl)amino]-, trans-, ACMC-20n5q7, SureCN384229, SureCN384230, SureCN8263972, CTK0E8699 ...
Selective oxidation of cyclohexanol to cyclohexanone in the ionic liquid 1-octyl-3-methylimidazolium chloride - Chemical...
... conversion of cyclohexanol with 100% selectivity to cyclohexanone using hydrogen peroxide as an oxidant and WO3 as a catalyst. ... 1-octyl-3-methylimidazolium chloride was found to effectively intensify cyclohexanol oxidation and resulted in 100% ... cyclohexanol. oxidation. and resulted in 100% conversion of cyclohexanol. with 100% selectivity to cyclohexanone. using ... cyclohexanol. to cyclohexanone. in the ionic liquid. 1-octyl-3-methylimidazolium chloride. L. Chen, T. Zhou, L. Chen, Y. Ye, Z ...
167081-25-6 - cis-4-(Boc-amino)cyclohexanol, 97% - tert-Butyl cis-4-hydroxycyclohexylcarbamate - H62238 - Alfa Aesar
Synthesis and Characterization of Iron Oxide Nanoparticles Supported on Ziconia and Its Application in the Gas-Phase Oxidation...
Catalytic activities of the catalysts were tested in the gas-phase conversion of cyclohexanol in a fixed-bed flow type, Pyrex ... in the gas-phase oxidation of cyclohexanol to cyclohexanone. Experimental results showed that there was no leaching of metal, ... thereby suggesting the oxidation of cyclohexanol to cyclohexanone. Furthermore, the catalytic activity of iron oxide ... Catalytic activities of the catalysts were tested in the gas-phase conversion of cyclohexanol in a fixed-bed flow type, Pyrex ...
2-methyl-5-(2-methyl-2-oxiranyl)cyclohexanol | C10H18O2 - ChemSynthesis
trans-4-(Boc-amino)cyclohexanol | 100 g | Toronto Research Chemicals - Bio-Connect
... cyclohexanol , Packing: 100 g , Brand: Toronto Research Chemicals , Other sizes available ... trans-4-(Boc-amino)cyclohexanol is an intermediate in the synthesis of potent activators of Heme-regulated inhibitor kinase. ... cyclohexanol; trans-tert-Butyl (4-Hydroxycyclohexyl)carbamate; (trans-4-Hydroxycyclohexyl)carbamic Acid 1,1-Dimethylethyl Ester ...
Cyclohexanol
Identification of a Transcriptional Activator (ChnR) and a 6-Oxohexanoate Dehydrogenase (ChnE) in the Cyclohexanol Catabolic...
Pathway of degradation of cyclohexanol byAcinetobacter sp. strain NCIMB 9871. ChnA, cyclohexanol dehydrogenase; ChnB, ... The metabolism of cyclohexanol by Acinetobacter NCIB 9871. Eur. J. Biochem. 60 1975 1 7 ... strain NCIMB 9871 is capable of utilizing cyclohexanol as a sole carbon source for growth (9). This organism is best known for ... The fact that the remaining genes in the cyclohexanol degradation pathway appear to be present in three separate operons (13) ...
Cyclohexanol to Cyclohexene | Distillation | Chemical Reactions
Cyclohexanol to Cyclohexene - Free download as Word Doc (.doc), PDF File (.pdf), Text File (.txt) or read online for free. ... cyclohexanol (note, this is 10.0 g not 10.0 mL), and a boiling. chip. Put a cork on the top of the flask, and shake gently to ... Dehydration of cyclohexanol to cyclohexene can be accomplished by. pyrolysis of the cyclic secondary alcohol with an acid ... Cyclohexene from Cyclohexanol. from K. L. Williamson, Macroscale and Microscale Organic. Experiments, 2nd Ed. 1994, Houghton ...
CyclohexanoneCyclohexaneDehydrationDehydrogenaseAlcoholsCyclohexylSystematic nameConversion of CyclohexanolHydrogenSynthesisPhenolConvert cyclohexanolConverts cyclohexanolDegradationMethylAlcoholPhosphoric acidAdipic acidMetabolism9871PhenylAcidExperimentReactionsEnzymeChemical PropertiesWaterConcentrationToxicCompoundsNylonOrganicMolecularInvolves
Cyclohexanone18
- Cyclohexanol is produced by the oxidation of cyclohexane in air, typically using cobalt catalysts: C6H12 + 1/2 O2 → C6H11OH This process co-forms cyclohexanone, and this mixture ("KA oil" for ketone-alcohol oil) is the main feedstock for the production of adipic acid. (wikipedia.org)
- Alternatively, cyclohexanol can be produced by the hydrogenation of phenol: C6H5OH + 3 H2 → C6H11OH This process can also be adjusted to favor the formation of cyclohexanone. (wikipedia.org)
- Michael Tuttle Musser "Cyclohexanol and Cyclohexanone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. (wikipedia.org)
- In enzymology, a cyclohexanol dehydrogenase (EC 1.1.1.245) is an enzyme that catalyzes the chemical reaction cyclohexanol + NAD+ ⇌ {\displaystyle \rightleftharpoons } cyclohexanone + NADH + H+ Thus, the two substrates of this enzyme are cyclohexanol and NAD+, whereas its 3 products are cyclohexanone, NADH, and H+. (wikipedia.org)
- A few drops of cyclohexanol is added and a clear reaction is observed for the formation of cyclohexanone. (rsc.org)
- This is due to the differences in physical properties such as surface tension and viscosity of the product (cyclohexanone) compared to the reactant (cyclohexanol). (rsc.org)
- Kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a. (springer.com)
- The kinetics of dehydrogenation of cyclohexanol to cyclohexanone on a Bag type copperalloy catalyst has been studied. (springer.com)
- Cyclohexanol dehydrogenase catalyzes the oxidation of the substrate to cyclohexanone. (nih.gov)
- Ionic liquid (IL) 1-octyl-3-methylimidazolium chloride was found to effectively intensify cyclohexanol oxidation and resulted in 100% conversion of cyclohexanol with 100% selectivity to cyclohexanone using hydrogen peroxide as an oxidant and WO 3 as a catalyst . (rsc.org)
- Catalytic activities of the catalysts were tested in the gas-phase conversion of cyclohexanol in a fixed-bed flow type, Pyrex glass reactor, at 433 - 463 K. Major detected products were cyclohexanone, cyclohexene and benzene, depending on the used catalyst. (scirp.org)
- The rate of reaction was significantly raised by the introduction of molecular oxygen in the feed gas, thereby suggesting the oxidation of cyclohexanol to cyclohexanone. (scirp.org)
- Furthermore, the catalytic activity of iron oxide nanoparticles supported on zirconia treated with hydrogen at 553 K for 2 hours, was more selective and better than the unreduced iron oxide nanoparticles supported on zirconia, in the gas-phase oxidation of cyclohexanol to cyclohexanone. (scirp.org)
- M. Sadiq, G. Zamin, R. and M. Ilyas, "Synthesis and Characterization of Iron Oxide Nanoparticles Supported on Ziconia and Its Application in the Gas-Phase Oxidation of Cyclohexanol to Cyclohexanone," Modern Research in Catalysis , Vol. 3 No. 1, 2014, pp. 12-17. (scirp.org)
- Subsequent detailed studies on the impact of the starting material, intermediate and product components revealed a significant inhibition and partial deactivation of the BVMO by the product ɛ-caprolactone (in particular at higher concentrations) as well as an inhibition of the BVMO by cyclohexanol and cyclohexanone. (uni-bielefeld.de)
- Electroantennogram recordings from transformed and wild-type flies were used to identify cyclohexanol, cyclohexanone, benzaldehyde, and benzyl alcohol as ligands for the Or43a. (pnas.org)
- Decarboxylation is accomplished by mixing about 80 g tryptophan in 250 mL of high-boiling solvent (xylene, DMSO, cyclohexanol, etc.), adding a dash of a ketone (I like 5 g of cyclohexanone, but a couple grams of MEK works reasonably well), heat it to around 150 deg, and when evolution of CO 2 ceases/solution is clear, the reaction is complete. (erowid.org)
- 26. Cyclohexanol & Cyclohexanone. (routledge.com)
Cyclohexane4
- Nickel is found to demonstrate high performance in the amination of cyclohexanol into cyclohexylamine in water and two solvents with low boiling points: tetrahydrofuran and cyclohexane. (mdpi.com)
- Production Methods Cyclohexanol is prepared by the catalytic air oxidation of cyclohexane or by the catalytic hydrogenation of phenol. (chemicalbook.com)
- The experiment thus far has completed the first three steps in the cycle: the dehydration of cyclohexanol (79.75% yield) which utilized Montmorillonite K10 and heat as reagents, the bromination of cyclohexane (67.34% yield) which utilized HBr, H2O2, and H2O as reagents, and the debromination of trans-1,2-dibromocyclohexane (95.89% yield) which utilized Zinc, H2O, and heat as reagents. (shalom-retreats.com)
- Cyclohexanols are compounds containing an alcohol group attached to a cyclohexane ring. (hmdb.ca)
Dehydration11
- Discussion & Conclusion In this experiment we learned how to synthesize the cyclohexene by dehydration of cyclohexanol. (antiessays.com)
- This experiment features the dehydration of cyclohexanol and produce cyclohexene. (antiessays.com)
- Dehydration of cyclohexanol to cyclohexene can be accomplished by pyrolysis of the cyclic secondary alcohol with an acid catalyst at a moderate temperature or by distillation over alumina or silica gel. (scribd.com)
- Here we demonstrate that hydronium ions confined in the nanopores of zeolite HBEA catalyse aqueous phase dehydration of cyclohexanol at a rate significantly higher than hydronium ions in water. (nature.com)
- for both cases, the dehydration of cyclohexanol occurs via an E1 mechanism with the cleavage of C β -H bond being rate determining. (nature.com)
- To delineate the thermodynamic and kinetic impact of the sub-nanometre-sized confines on the catalytic chemistry of hydronium ions, the kinetics and elementary steps of the dehydration of a secondary alcohol, cyclohexanol, in water and in pores of zeolite Beta (BEA) are explored. (nature.com)
- Dehydration of cyclohexanol catalysed by dilute hydronium ions (dissociated from H 3 PO 4 ) leads solely to the formation of cyclohexene. (nature.com)
- In the dehydration of cyclohexanol, Montmorillonite K10 clay was used as an acid catalyst, which promoted dehydration. (shalom-retreats.com)
- Analysis of the loss of cyclohexanol by the dehydration reaction with phosphoric acid was scrutinized in heterogeneous media as well as homogenous media. (kzoo.edu)
- The dehydration rate of cyclohexanol increased with an increased interfacial region. (kzoo.edu)
- The dehydration rate of cyclohexanol by phosphoric acid was determined to be e-0.012x, e-0.006x, and e-0.002x at droplet distances of 0 mm, 50 mm, and 91 mm, respectively. (kzoo.edu)
Dehydrogenase2
- Identification of a Transcriptional Activator (ChnR) and a 6-Oxohexanoate Dehydrogenase (ChnE) in the Cyclohexanol Catabolic Pathway in Acinetobacter sp. (asm.org)
- The gene sequence of chnE , which encodes an NADP + -linked 6-oxohexanoate dehydrogenase, the enzyme catalyzing the fifth step of cyclohexanol degradation, was also determined. (asm.org)
Alcohols2
- This is a quick microscale experiment to illustrate that alcohols like cyclohexanol react with acidified dichromate(VI). (rsc.org)
- Alkenes from Alcohols: Cyclohexene from Cyclohexanol 20. (abebooks.com)
Cyclohexyl2
- cyclohexyl cation + hydrogen sulphate + water protonated cyclohexanol + cyclohexyl hydrogen sulphate 3. (shalom-retreats.com)
- cyclohexyl hydrogen sulphate protonated cyclohexanol + HSO4 4. (shalom-retreats.com)
Systematic name1
- The systematic name of this enzyme class is cyclohexanol:NAD+ oxidoreductase. (wikipedia.org)
Conversion of Cyclohexanol1
- Qi Y, Yu H, Cao Q, Dong B, Mu X, Mao A. Nickel Catalyzed Conversion of Cyclohexanol into Cyclohexylamine in Water and Low Boiling Point Solvents. (mdpi.com)
Hydrogen2
- INTISARI Pabrik cyclohexanol dari phenol dan hydrogen dengan kapasitas 25.000 ton/tahun direncanakan didirikan di Kawasan Industri Cilacap, Jawa Tengah dengan luas tanah 5.279 m2. (upnyk.ac.id)
- Reaksi pembuatan cyclohexanol diawali dengan mereaksikan phenol dan hydrogen dengan fase gas - gas dalam Reaktor Fixedbed (R-01) pada kondisi suhu reaktor 190,04 oC dan tekanan 1,3 atm. (upnyk.ac.id)
Synthesis3
- trans-4-(Boc-amino)cyclohexanol is an intermediate in the synthesis of potent activators of Heme-regulated inhibitor kinase. (bio-connect.nl)
- Synthesis of Cyclohexanol Author: Ahmed Ayyash 06/06/13 Introduction: In this experiment, cyclohexanol was prepared from an initial cyclohexene. (shalom-retreats.com)
- Jope, RS & Johnson, GVW 1986, ' Quinacrine and 2-(4-phenylpiperidino)cyclohexanol (AH5183) inhibit acetylcholine release and synthesis in rat brain slices ', Molecular Pharmacology , vol. 29, no. 1, pp. 45-51. (elsevier.com)
Phenol2
- Campuran air, cyclohexanon, cyclohexanol dan phenol dalam fase gas dialirkan menuju Condensor Partial (CDP-01). (upnyk.ac.id)
- Dengan demikian ditinjau dari segi teknis dan ekonomi, pabrik cyclohexanol dari phenol dan hidrogen layak untuk dipertimbangkan dan dikaji lebih lanjut. (upnyk.ac.id)
Convert cyclohexanol1
- 14-36 Show how to convert cyclohexanol to these compounds. (bartleby.com)
Converts cyclohexanol2
- Heating in the presence of acid catalysts converts cyclohexanol to cyclohexene. (wikipedia.org)
- The development of a biocatalytic process concept for ɛ-caprolactone, which directly converts cyclohexanol as an easily available industrial raw material into the desired ɛ-caprolactone in a one-pot fashion while only requiring air as sole reagent, is reported. (uni-bielefeld.de)
Degradation3
- The enzymes involved in the anaerobic degradation of cyclohexanol were searched for in a denitrifying Pseudomonas species which metabolizes this alicyclic compound to CO2 anaerobically. (nih.gov)
- We are interested in isolating and characterizing additional genes of the cyclohexanol degradation (designated chn for c yclo h exa n ol) pathway (Fig. 1 ) with the goal of determining the regulation of this pathway and its potential for biocatalysis and strain development. (asm.org)
- Pathway of degradation of cyclohexanol by Acinetobacter sp. (asm.org)
Methyl2
- R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the additive. (freepatentsonline.com)
- Recrystallization from isopropanol gives (R*,R*)2-[(dimethylamino)methyl]-1-(3-metboxyphenyl)cyclohexanol hydrochloride free of the nitrile solvent. (freepatentsonline.com)
Alcohol4
- Cyclohexanol undergoes the main reactions expected for a secondary alcohol. (wikipedia.org)
- Reactivity Profile Cyclohexanol is an alcohol. (chemicalbook.com)
- In the experiment a secondary alcohol (cyclohexanol) is heated with acid (phosphoric acid). (antiessays.com)
- A carbocation is generated by the loss of water from cyclohexanol because of the protonated alcohol. (antiessays.com)
Phosphoric acid2
- In the present study, the interactions between cyclohexanol and phosphoric acid on glass beads were investigated at varying areas of interfacial boundaries over time. (kzoo.edu)
- It was concluded that the larger the area of the interface between the reactants was, the greater the acid-base interaction between cyclohexanol and phosphoric acid was and, ultimately, the greater the loss of cyclohexanol over time. (kzoo.edu)
Adipic acid2
- Uses Cyclohexanol is used for the productionof adipic acid and caprolactam for makingnylon. (chemicalbook.com)
- The most important use of cyclohexanol is in producing adipic acid used in the manufacture of caprolactam. (chemicalbook.com)
Metabolism1
- The effects of 2-(4-phenylpiperidino)cyclohexanol (AH5183) and quinacrine, two potent inhibitors of acetylcholine transport into vesicles isolated from Torpedo electric organ, were examined on acetylcholine metabolism in rat cortical slices. (elsevier.com)
98711
- strain NCIMB 9871 is capable of utilizing cyclohexanol as a sole carbon source for growth ( 9 ). (asm.org)
Phenyl2
- 2-Phenyl propionic acid, ibuprofen and trans-2-phenyl-1-cyclohexanol were resolved using commercial Rhizomucor miehei lipase (Lipozyme IM20) and Candida rugosa lipase produced in our laboratory immobilised on EP100 polypropylene powder. (uab.cat)
- Candida rugosa lipase was more enantioselective in the resolution of the tested substrates, especially with trans-2-phenyl-1-cyclohexanol, whereas the lipase from Rhizomucor miehei did not show catalytic activity with this substrate. (uab.cat)
Acid2
- When a mixture of cyclohexanol and sulfuric acid is heated in a flask equipped with a fractionating column, the formation of water is soon evident. (scribd.com)
- To this, add 2.0 mL of concentrated sulfuric acid, followed by 10.0 g of cyclohexanol (note, this is 10.0 g not 10.0 mL), and a boiling chip. (scribd.com)
Experiment3
- If this experiment is done on a warm day the cyclohexanol is liquid and therefore easier to sample. (rsc.org)
- The first three labs of this organic chemistry experiment involved carrying out the first three parts of the Cyclohexanol Cycle. (shalom-retreats.com)
- This experiment carries out a series of steps to carry out the Cyclohexanol Cycle. (shalom-retreats.com)
Reactions1
- The above table demonstrates the mass of product and calculated percent yields for the first three reactions in the Cyclohexanol Cycle. (shalom-retreats.com)
Enzyme1
- Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone", Enzyme and microbial technology , vol. 53, 2013, pp. 288-292. (uni-bielefeld.de)
Chemical Properties1
- Chemical Properties Cyclohexanol is a sticky solid (above 25℃ /77℃ F) or colorless, viscous liquid. (chemicalbook.com)
Water4
- The azeotropes of cyclohexanol/water and cyclohexene/water are both positive azeotropes. (antiessays.com)
- soly of water in cyclohexanol: 11% (w/w). (drugfuture.com)
- On further heating, the water and the cyclohexene formed distill together by the principle of steam distillation, and any high-boiling cyclohexanol that may volatilize is returned to the flask. (scribd.com)
- The cyclohexanol was first converted to cyclohexene and water by simple distillation (product: 6.5395g, 79.75% recovery). (shalom-retreats.com)
Concentration1
- The test was conducted at a sludge concentration of 30 mg/L and with 100 mg cyclohexanol/L. The cultivating duration was 28 days. (europa.eu)
Toxic2
- Cyclohexanol is somewhat toxic: the TLV for the vapor for 8 h is 50 ppm. (wikipedia.org)
- Health Hazard Cyclohexanol is moderately toxic. (chemicalbook.com)
Compounds1
- belongs to the class of organic compounds known as cyclohexanols. (hmdb.ca)
Nylon1
- The final step involves converting the cyclohexanol to nylon 6,6 (Dintzner 262). (shalom-retreats.com)
Organic1
- Cyclohexanol is the organic compound with the formula HOCH(CH2)5. (wikipedia.org)
Molecular1
- Staudt S, Bornscheuer UT, Menyes U, Hummel W, Gröger H. Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. (uni-bielefeld.de)
Involves1
- The Cyclohexanol Cycle is a multistep process that involves reacting and recycling the same product. (shalom-retreats.com)