Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.

The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. (1/579)

Upon activation, brain microglial cells release proinflammatory mediators, such as nitric oxide (NO), which may play an important role in the central nervous system antibacterial, antiviral, and antitumor activities. However, excessive release of NO has been postulated to elicit immune-mediated neurodegenerative inflammatory processes and to cause brain injury. In the present study, the effect of cannabinoids on the release of NO from endotoxin/cytokine-activated rat cortical microglial cells was evaluated. A drug dose-dependent (0.1 microM-8 microM) inhibition of NO release from rat microglial cells was exerted by the cannabinoid receptor high-affinity binding enantiomer (-)-CP55940. In contrast, a minimal inhibitory effect was exerted by the lower affinity binding paired enantiomer (+)-CP56667. Pretreatment of microglial cells with the Galphai/Galphao protein inactivator pertussis toxin, cyclic AMP reconstitution with the cell-permeable analog dibutyryl-cAMP, or treatment of cells with the Galphas activator cholera toxin, resulted in reversal of the (-)-CP55940-mediated inhibition of NO release. A similar reversal in (-)-CP55940-mediated inhibition of NO release was effected when microglial cells were pretreated with the central cannabinoid receptor (CB1) selective antagonist SR141716A. Mutagenic reverse transcription-polymerase chain reaction, Western immunoblot assay using a CB1 receptor amine terminal domain-specific antibody, and cellular colocalization of CB1 and the microglial marker Griffonia simplicifolia isolectin B4 confirmed the expression of the CB1 receptor in rat microglial cells. Collectively, these results indicate a functional linkage between the CB1 receptor and cannabinoid-mediated inhibition of NO production by rat microglial cells.  (+info)

Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. (2/579)

The effects of cannabinoid agonists on noxious heat-evoked firing of 62 spinal wide dynamic range (WDR) neurons were examined in urethan-anesthetized rats (1 cell/animal). Noxious thermal stimulation was applied with a Peltier device to the receptive fields in the ipsilateral hindpaw of isolated WDR neurons. To assess the site of action, cannabinoids were administered systemically in intact and spinally transected rats and intraventricularly. Both the aminoalkylindole cannabinoid WIN55,212-2 (125 microg/kg iv) and the bicyclic cannabinoid CP55,940 (125 microg/kg iv) suppressed noxious heat-evoked activity. Responses evoked by mild pressure in nonnociceptive neurons were not altered by CP55,940 (125 microg/kg iv), consistent with previous observations with another cannabinoid agonist, WIN55,212-2. The cannabinoid induced-suppression of noxious heat-evoked activity was blocked by pretreatment with SR141716A (1 mg/kg iv), a competitive antagonist for central cannabinoid CB1 receptors. By contrast, intravenous administration of either vehicle or the receptor-inactive enantiomer WIN55,212-3 (125 microg/kg) failed to alter noxious heat-evoked activity. The suppression of noxious heat-evoked activity induced by WIN55,212-2 in the lumbar dorsal horn of intact animals was markedly attenuated in spinal rats. Moreover, intraventricular administration of WIN55,212-2 suppressed noxious heat-evoked activity in spinal WDR neurons. By contrast, both vehicle and enantiomer were inactive. These findings suggest that cannabinoids selectively modulate the activity of nociceptive neurons in the spinal dorsal horn by actions at CB1 receptors. This modulation represents a suppression of pain neurotransmission because the inhibitory effects are selective for pain-sensitive neurons and are observed with different modalities of noxious stimulation. The data also provide converging lines of evidence for a role for descending antinociceptive mechanisms in cannabinoid modulation of spinal nociceptive processing.  (+info)

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. (3/579)

The human cannabinoid receptors, central cannabinoid receptor (CB1) and peripheral cannabinoid receptor (CB2), share only 44% amino acid identity overall, yet most ligands do not discriminate between receptor subtypes. Site-directed mutagenesis was employed as a means of mapping the ligand recognition site for the human CB2 cannabinoid receptor. A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function. The analogous mutation in the CB1 receptor (K192A) was found to be crucial for recognition of several cannabinoid compounds excluding (R)-(+)-[2, 3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1, 4-benzoxazin-6-yl](1-naphthalenyl)methanone (WIN 55,212-2). In contrast, in human embryonic kidney (HEK)-293 cells expressing the mutant or wild-type CB2 receptors, we found no significant differences in either the binding profile of several cannabinoid ligands nor in inhibition of cAMP accumulation. We identified a high-affinity site for (-)-3-[2-hydroxyl-4-(1, 1-dimethylheptyl)phenyl]-4-[3-hydroxyl propyl] cyclohexan-1-ol (CP-55,940) in the region of helices 3, 6, and 7, with S3.31(112), T3.35(116), and N7.49(295) in the K109A mutant using molecular modeling. The serine residue, unique to the CB2 receptor, was then mutated to glycine in the K109A mutant. This double mutant, K109AS112G, retains the ability to bind aminoalkylindoles but loses affinity for classical cannabinoids, as predicted by the molecular model. Distinct cellular localization of the mutant receptors observed with immunofluorescence also suggests differences in receptor function. In summary, we identified amino acid residues in the CB2 receptor that could lead to subtype specificity.  (+info)

Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. (4/579)

1. The aim of the present study was to analyse the cardiovascular actions of the synthetic CB1/CB2 cannabinoid receptor agonist WIN55212-2, and specifically to determine its sites of action on sympathetic cardiovascular regulation. 2. Pithed rabbits in which the sympathetic outflow was continuously stimulated electrically or which received a pressor infusion of noradrenaline were used to study peripheral prejunctional and direct vascular effects, respectively. For studying effects on brain stem cardiovascular regulatory centres, drugs were administered into the cisterna cerebellomedullaris in conscious rabbits. Overall cardiovascular effects of the cannabinoid were studied in conscious rabbits with intravenous drug administration. 3. In pithed rabbits in which the sympathetic outflow was continuously electrically stimulated, intravenous injection of WIN55212-2 (5, 50 and 500 microg kg(-1)) markedly reduced blood pressure, the spillover of noradrenaline into plasma and the plasma noradrenaline concentration, and these effects were antagonized by the CB1 cannabinoid receptor-selective antagonist SR141716A. The hypotensive and the sympathoinhibitory effect of WIN55212-2 was shared by CP55940, another mixed CB1/CB2 cannabinoid receptor agonist, but not by WIN55212-3, the enantiomer of WIN55212-2, which lacks affinity for cannabinoid binding sites. WIN55212-2 had no effect on vascular tone established by infusion of noradrenaline in pithed rabbits. 4. Intracisternal application of WIN55212-2 (0.1, 1 and 10 microg kg(-1)) in conscious rabbits increased blood pressure and the plasma noradrenaline concentration and elicited bradycardia; this latter effect was antagonized by atropine. 5. In conscious animals, intravenous injection of WIN55212-2 (5 and 50 microg kg(-1)) caused bradycardia, slight hypotension, no change in the plasma noradrenaline concentration, and an increase in renal sympathetic nerve firing. The highest dose of WIN55212-2 (500 microg kg(-1)) elicited hypotension and tachycardia, and sympathetic nerve activity and the plasma noradrenaline concentration declined. 6. The results obtained in pithed rabbits indicate that activation of CB1 cannabinoid receptors leads to marked peripheral prejunctional inhibition of noradrenaline release from postganglionic sympathetic axons. Intracisternal application of WIN55212-2 uncovered two effects on brain stem cardiovascular centres: sympathoexcitation and activation of cardiac vagal fibres. The highest dose of systemically administered WIN55212-2 produced central sympathoinhibition; the primary site of this action is not known.  (+info)

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. (5/579)

We have tested our prediction that AM630 is a CB2 cannabinoid receptor ligand and also investigated whether L759633 and L759656, are CB2 receptor agonists. Binding assays with membranes from CHO cells stably transfected with human CB1 or CB2 receptors using [3H]-CP55940, confirmed the CB2-selectivity of L759633 and L759656 (CB2/CB1 affinity ratios = 163 and 414 respectively) and showed AM630 to have a Ki at CB2 receptors of 31.2 nM and a CB2/CB1 affinity ratio of 165. In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. AM630 inhibited [35S]-GTPgammaS binding to CB2 receptor membranes (EC50 = 76.6 nM), enhanced forskolin-stimulated cyclic AMP production in CB2-transfected cells (5.2 fold by 1 microM), and antagonized the inhibition of forskolin-stimulated cyclic AMP production in this cell line induced by CP55940. In CB1-transfected cells, forskolin-stimulated cyclic AMP production was significantly inhibited by AM630 (22.6% at 1 microM and 45.9% at 10 microM) and by L759633 at 10 microM (48%) but not 1 microM. L759656 (10 microM) was not inhibitory. AM630 also produced a slight decrease in the mean inhibitory effect of CP55940 on cyclic AMP production which was not statistically significant. We conclude that AM630 is a CB2-selective ligand that behaves as an inverse agonist at CB2 receptors and as a weak partial agonist at CB1 receptors. L759633 and L759656 are both potent CB2-selective agonists.  (+info)

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. (6/579)

The biotransformation of venlafaxine (VF) into its two major metabolites, O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) was studied in vitro with human liver microsomes and with microsomes containing individual human cytochromes from cDNA-transfected human lymphoblastoid cells. VF was coincubated with selective cytochrome P450 (CYP) inhibitors and several selective serotonin reuptake inhibitors (SSRIs) to assess their inhibitory effect on VF metabolism. Formation rates for ODV incubated with human microsomes were consistent with Michaelis-Menten kinetics for a single-enzyme mediated reaction with substrate inhibition. Mean parameters determined by non-linear regression were: Vmax = 0.36 nmol/min/mg protein, K(m) = 41 microM, and Ks 22901 microM (Ks represents a constant which reflects the degree of substrate inhibition). Quinidine (QUI) was a potent inhibitor of ODV formation with a Ki of 0.04 microM, and paroxetine (PX) was the most potent SSRI at inhibiting ODV formation with a mean Ki value of 0.17 microM. Studies using expressed cytochromes showed that ODV was formed by CYP2C9, -2C19, and -2D6. CYP2D6 was dominant with the lowest K(m), 23.2 microM, and highest intrinsic clearance (Vmax/K(m) ratio). No unique model was applicable to the formation of NDV for all four livers tested. Parameters determined by applying a single-enzyme model were Vmax = 2.14 nmol/min/mg protein, and K(m) = 2504 microM. Ketoconazole was a potent inhibitor of NDV production, although its inhibitory activity was not as great as observed with pure 3A substrates. NDV formation was also reduced by 42% by a polyclonal rabbit antibody against rat liver CYP3A1. Studies using expressed cytochromes showed that NDV was formed by CYP2C9, -2C19, and -3A4. The highest intrinsic clearance was attributable to CYP2C19 and the lowest to CYP3A4. However the high in vivo abundance of 3A isoforms will magnify the importance of this cytochrome. Fluvoxamine (FX), at a concentration of 20 microM, decreased NDV production by 46% consistent with the capacity of FX to inhibit CYP3A, 2C9, and 2C19. These results are consistent with previous studies that show CYP2D6 and -3A4 play important roles in the formation of ODV and NDV, respectively. In addition we have shown that several other CYPs have important roles in the biotransformation of VF.  (+info)

Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. (7/579)

Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2). These genomic modulations observed on large-scale cDNA arrays were first confirmed by Northern blot studies. Furthermore, ELISA evaluations in culture supernatants indicated that the cannabinoid-induced activation of these two chemokine genes was followed by enhanced expression and secretion of the corresponding proteins. These upregulations initially observed in transfected HL60 cells overexpressing CB2 receptors, also occurred in normal non-transfected HL60 cells. The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors. More specifically, the abolition of the cannabinoid-induced effect by the specific CB2 antagonist SR 144528 indicated a strict peripheral cannabinoid-mediated process. Altogether, our data highlight a possible new function of peripheral cannabinoid receptors in the modulation of immune and inflammatory responses.  (+info)

Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways. (8/579)

We previously showed that the cannabinoid receptor CB1 stably transfected in Chinese hamster ovary cells was constitutively active and could be inhibited by the inverse agonist SR 141716A. In the present study, we demonstrate that the cannabinoid agonist CP-55940 induced cytosol alkalinization of CHO-CB1 cells in a dose- and time-dependent manner via activation of the Na+/H+ exchanger NHE-1 isoform. By contrast, the inverse agonist SR 141716A induced acidification of the cell cytosol, suggesting that the Na+/H+ exchanger NHE-1 was constitutively activated by the CB1 receptor. CB1-mediated NHE1 activation was prevented by both pertussis toxin treatment and the specific MAP kinase inhibitor PD98059. NHE-1 and p42/p44 MAPK had a similar time course of activation in response to the addition of CP-55940 to CHO-CB1 cells. These results suggest that CB1 stimulates NHE-1 by G(i/o)-mediated activation of p42/p44 MAP kinase and highlight a cellular physiological process targeted by CB1.  (+info)

Cyclohexanols are a class of organic compounds that contain a cyclohexane ring (a six-carbon saturated ring) with a hydroxyl group (-OH) attached to it. The hydroxyl group makes these compounds alcohols, and the cyclohexane ring provides a unique structure that can adopt different conformations.

The presence of the hydroxyl group in cyclohexanols allows them to act as solvents, intermediates in chemical synthesis, and starting materials for the production of other chemicals. They are used in various industries, including pharmaceuticals, agrochemicals, and polymers.

Cyclohexanols can exist in different forms, such as cis- and trans-isomers, depending on the orientation of the hydroxyl group relative to the cyclohexane ring. The physical and chemical properties of these isomers can differ significantly due to their distinct structures and conformations.

Examples of cyclohexanols include cyclohexanol itself (C6H11OH), as well as its derivatives, such as methylcyclohexanol (C7H13OH) and phenylcyclohexanol (C12H15OH).

... has at least two solid phases. One of them is a plastic crystal. As indicated above, cyclohexanol is an important ... Cyclohexanol is moderately toxic: the Threshold Limit Value for the vapor for 8 h is 50 ppm. The IDLH concentration is set at ... Cyclohexanol is the organic compound with the formula HOCH(CH2)5. The molecule is related to cyclohexane by replacement of one ... Alternatively, cyclohexanol can be produced by the hydrogenation of phenol: C6H5OH + 3 H2 → C6H11OH This process can also be ...
In enzymology, a cyclohexanol dehydrogenase (EC 1.1.1.245) is an enzyme that catalyzes the chemical reaction cyclohexanol + ... Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ... Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ... The systematic name of this enzyme class is cyclohexanol:NAD+ oxidoreductase. This enzyme participates in caprolactam ...
... (IBCH, Sandenol) is an organic compound used primarily as a fragrance because of its aroma which is ...
The (−)-cyclohexanol and the (+)-ester are separated by fractional crystallization and the isolated (+)-ester hydrolyzed to the ... trans-2-Phenyl-1-cyclohexanol is an organic compound. The two enantiomers of this compound are used in organic chemistry as ... cyclohexanol in a separate step. The enantiomers have also been prepared by the Sharpless asymmetric dihydroxylation of 1- ... "Sharpless bishydroxylation procedure to trans-2-phenyl-1-cyclohexanol". Organic Syntheses.{{cite journal}}: CS1 maint: multiple ...
... , also known as PPC, is an organic chemical which is a metabolite of phencyclidine (PCP ... "Behavioral effects of phencyclidine and its major metabolite, (trans)4-phenyl-4-(1-piperidinyl)cyclohexanol, in mice". v t e ( ...
"Cyclohexanol, method for producing cyclohexanol, and method for producing adipic acid", published 26 Sep 2017 G. H. Coleman, H ... In the laboratory, it can be prepared by dehydration of cyclohexanol. Benzene is converted to cyclohexylbenzene by acid- ... Hydration of cyclohexene gives cyclohexanol, which can be dehydrogenated to give cyclohexanone, a precursor to caprolactam. The ... Musser, Michael T. (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ...
Like cyclohexanol, cyclohexanone is not carcinogenic and is moderately toxic, with a TLV of 25 ppm for the vapor. It is an ... "Oxidation of Cyclohexanol to Cyclohexanone". Archived from the original on 2012-04-26. Retrieved 2012-07-09. M. S. Newman; M. D ... In some cases, purified cyclohexanol, obtained by hydration of cyclohexene, is the precursor. Alternatively, cyclohexanone can ... Cyclohexanone can be prepared from cyclohexanol by oxidation with chromium trioxide (Jones oxidation). An alternative method ...
The cyclohexanone-cyclohexanol mixture, called "KA oil", is a raw material for adipic acid and caprolactam, precursors to nylon ... Several million kilograms of cyclohexanone and cyclohexanol are produced annually. It is used as a solvent in some brands of ... Michael Tuttle Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley ... Although rather unreactive, cyclohexane undergoes catalytic oxidation to produce cyclohexanone and cyclohexanol. ...
Michael T. Musser (2005). "Cyclohexanol and Cyclohexanone". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH ...
Pichika Ramaiah; Ramesh Krishnamurti; G. K. Surya Prakash (1995). "1-Trifluoromethyl-1-cyclohexanol". Org. Synth. 72: 232. doi: ...
Pichika Ramaiah, Ramesh Krishnamurti, and G. K. Surya Prakash (1998). "1-trifluoromethyl)-1-cyclohexanol". Organic Syntheses: ...
"1-TRIFLUOROMETHYL-1-CYCLOHEXANOL". Organic Syntheses. 72 (72): 232. doi:10.15227/orgsyn.072.0232. Morimoto, H.; Tsubogo, T.; ...
Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ...
nov., a cyclohexanol-degrading, nitrate-reducing beta-proteobacterium". International Journal of Systematic and Evolutionary ...
Accidentally, this enzyme also oxidizes, at no additional cost for M. vaccae, cyclohexane into cyclohexanol. Thus, cyclohexane ... The latter can metabolize cyclohexanol, but not cyclohexane. Some of the molecules that are cometabolically degraded by ...
Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ...
... is prepared by reaction of cyclohexanol with hydrogen fluoride. The compound causes serious skin and eye ...
... cyclohexanol". Experientia 34(9): 1124-1125. doi:10.1007/BF01922905. Paton, D.M.; Castaner, J.; Ciramadol. Drugs Fut 1980, 5, 6 ... Cyclohexanols, Dimethylamino compounds, All stub articles, Analgesic stubs). ...
4-Phenyl-4-(1-piperidinyl)cyclohexanol, another PCP metabolite Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Fukaya, Hiroaki; ...
Cyclohexanol from Cyclohexyl Methyl Ether". Organic Syntheses.; Collective Volume, vol. 6, p. 353 "GC/MS Analysis for Morphine ...
doi:10.1021/jo00249a039 (All accuracy disputes, Articles with disputed statements from June 2023, Polyols, Cyclohexanols). ...
... can be prepared from cyclohexanol by treatment with hydrogen chloride. Henry Gilman and W. E. Catlin (1926 ...
DCFP can be produced by reaction of cyclohexanol with phosphoryl dichloride fluoride. Diisopropyl phosphorofluoridate (DFP) ...
Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ...
Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ...
Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying ...
... (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent ... "4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use", issued 1982-12-28, assigned to Upjohn Company ...
Cyclohexanol from Cyclohexanone". Organic Syntheses. 69: 96. doi:10.15227/orgsyn.069.0096. M. Caporali, L. Gonsalvi, F. ...
The trans compound had rates identical to those found in the monosubstituted cyclohexanol. Using the A-values of the hydroxyl ...
... is produced from a mixture of cyclohexanone and cyclohexanol called KA oil, the abbreviation of ketone-alcohol oil ... Early in the reaction, the cyclohexanol is converted to the ketone, releasing nitrous acid: HOC6H11 + HNO3 → OC(CH2)5 + HNO2 + ... Related processes start from cyclohexanol, which is obtained from the hydrogenation of phenol. Several methods have been ...
Cyclohexanol has at least two solid phases. One of them is a plastic crystal. As indicated above, cyclohexanol is an important ... Cyclohexanol is moderately toxic: the Threshold Limit Value for the vapor for 8 h is 50 ppm. The IDLH concentration is set at ... Cyclohexanol is the organic compound with the formula HOCH(CH2)5. The molecule is related to cyclohexane by replacement of one ... Alternatively, cyclohexanol can be produced by the hydrogenation of phenol: C6H5OH + 3 H2 → C6H11OH This process can also be ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
What is cyclohexanol?. Cyclohexanol, 2-methyl-, trans- (.+/-.)- Straw-colored liquid with a weak odor of coconut oil. Less ... The dehydration of cyclohexanol to yield cyclohexene Cyclohexanol is heated with concentrated phosphoric(V) acid, and the ... Why is phosphoric acid added to the cyclohexanol?. If cyclohexanol is heated with a catalytic amount of phosphoric acid, ... What role does phosphoric acid play in the dehydration of cyclohexanol?. In the presence of a strong acid, an alcohol can be ...
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Parents of cyclohexanol metabolic process (GO:0018891) subject. relation. object. cyclohexanol metabolic process is_a secondary ... Children of cyclohexanol metabolic process (GO:0018891) subject. relation. object. cyclohexanol oxidation (GO:0019399) is_a ... cyclohexanol metabolic process. Ontology. biological_process. Synonyms. cyclohexanol metabolism. Alternate IDs. None. ... cyclohexanol metabolic process is_a xenobiotic metabolic process (GO:0006805) ...
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... which is considered most relevant with regards to human exposure to cyclohexanol. AF for remaining uncertainties:. 1. ... which is considered most relevant with regards to human exposure to cyclohexanol. AF for remaining uncertainties:. 1. ...
Cyclohexanol. 108-93-0. 1988. Cyclohexanone. 108-94-1. 1988. Cyclohexene. 110-83-8. 1988. ...
Skin notation profile: Cyclohexanol. *Skin notation profile: Cyclohexanone. *Skin notation profile: Cyclonite ...
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Cyclohexanol. 1.5 ± 0.2. 2-Pentanol. 1.5 ± 0.2. 2-Octanol. 0.5 ± 0.1. a It consisted of 5.5% (2S,3S)-2,3-butanediol, 12.9% (2R, ...
From cyclohexanol to diethyl hexanedioate (diethyl adipate): a two-step synthetic sequence for microscale organic laboratory. ... "From cyclohexanol to diethyl hexanedioate (diethyl adipate): A two-step synthetic sequence for microscale organic laboratory." ...
During World War I, in the spring of 1917, Riehl identified approximately 17 patients who had striking dark-brown to grayish-brown facial pigmentation that was most pronounced on the lateral aspects of the face and neck and primarily concentrated on the forehead, ears, temple, and zygomatic regions. Pigmentation was also noted on the thorax, ...
Cyclohexanol, 4-met. hylene-3-[(2E)-2-[(. 1R,3aS,7aR)-octahyd. ro-7a-methyl-1-[(1R. ,2E,4R)-1,4,5-trime. thyl-2-hexen-1-yl]-. ...
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Activity of Brønsted Acid Sites in UiO-66 for Cyclohexanol Dehydration ( Read More ) ...
1-(hydroxymethyl)cyclohexanol. Conditions. Conditions. Yield. With titanium(IV) dichlorodiisopropylate at 20℃; for 72h; UV- ...
The extracted acid is then derivatized with cyclohexanol to form a dicyclohexyl ester. The derivatized samples are injected ...
HMDB0009814 RDKit 3D PI(18:0/20:3(8Z,11Z,14Z)) 146146 0 0 0 0 0 0 0 0999 V2000 3.1444 -5.1983 6.9989 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9501 -3.7211 7.3152 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3711 -3.5092 8.7420 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2384 -2.1060 9.2190 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7724 -1.6543 9.1613 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6467 -0.2801 9.6581 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2276 0.7199 8.9780 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7844 0.8305 7.6267 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7715 -0.2543 6.6841 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.3093 -0.7583 6.1139 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.6721 -0.2909 6.3608 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.2307 0.2146 5.1042 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.3053 -0.3242 4.5851 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0807 -1.4385 5.1166 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0790 -2.5400 3.9936 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.8467 -3.7144 4.4465 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.9297 -4.9138 3.5745 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.4506 -4.7516 2.1888 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.5819 -4.0620 1.2157 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.2512 ...
BDBM5(cyclohexanol , cyclohexanol-d12). Show SMILES 3549. Show InChI 3549. ITC DataΔG°: -18.4kJ/mole −TΔS°: -14.9kJ/mole ΔH°: - ...
Cyclohexanol: E. Cyclohexanone: E. Decane: E. Dibromoethane: E. Dichlorobenzene: E. Dichlorodifluoromethane: G. Dichloroethane ...
Cyclohexanol, 1-(2-(dimethylamino)-1- o (4-methoxyphenyl)ethyl) hydrochloride o -1-(a-(dimethyl-amino)methyl-p-methoxybenzyl ...
  • Cyclohexanol is produced by the oxidation of cyclohexane in air, typically using cobalt catalysts: 2 C6H12 + O2 → 2 C6H11OH This process coforms cyclohexanone, and this mixture ("KA oil" for ketone-alcohol oil) is the main feedstock for the production of adipic acid. (wikipedia.org)
  • Alternatively, cyclohexanol can be produced by the hydrogenation of phenol: C6H5OH + 3 H2 → C6H11OH This process can also be adjusted to favor the formation of cyclohexanone. (wikipedia.org)
  • Michael Tuttle Musser "Cyclohexanol and Cyclohexanone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. (wikipedia.org)
  • Based on Raw Material, market is studied across Cyclohexanol and Cyclohexanone. (asdreports.com)
  • Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma. (nih.gov)
  • Use this quick class experiment to observe the oxidation of cyclohexanol to produce cyclohexanone. (rsc.org)
  • First we start my taking a solution of cyclohexanol, HOCH(CH2)5, which is a cyclohexane ring with an alcohol functional group attached to it. (stuffintheair.com)
  • The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. (planteome.org)
  • Heating in the presence of acid catalysts converts cyclohexanol to cyclohexene. (wikipedia.org)
  • If cyclohexanol is heated with a catalytic amount of phosphoric acid, elimination of water (dehydration) results in cyclohexene as the product. (pfeiffertheface.com)
  • What is the purpose of adding phosphoric acid H3PO4 when preparing cyclohexene from cyclohexanol? (pfeiffertheface.com)
  • The dehydration of cyclohexanol to yield cyclohexene Cyclohexanol is heated with concentrated phosphoric(V) acid, and the liquid cyclohexene distils off and can be collected and purified. (pfeiffertheface.com)
  • The conversion process from cyclohexanol to cyclohexene provides insight into chemical reactions and mechanisms. (stuffintheair.com)
  • The conversion of cyclohexanol to cyclohexene falls under organic chemistry. (stuffintheair.com)
  • In industry, cyclohexanol to cyclohexene conversion is important. (stuffintheair.com)
  • The conversion of cyclohexanol to cyclohexene involves experimental techniques common in organic chemistry. (stuffintheair.com)
  • Exploring the conversion of cyclohexanol to cyclohexene can be intellectually stimulating and personally fulfilling for them. (stuffintheair.com)
  • First, between cyclohexanol and phenol derivatives, in C6H5O- ion,one of the lone pairs on the oxygen atom overlaps with the delocalised electrons on the benzene ring. (brainmass.com)
  • This makes phenol derivatives more acidic than cyclohexanol derivatives. (brainmass.com)
  • The chemical name for tramadol hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. (nih.gov)
  • Chlorodiphenyl, Cyclohexanol , Diethylenetriamine and risk assessment science. (cdc.gov)
  • Cyclohexanol is the organic compound with the formula HOCH(CH2)5. (wikipedia.org)
  • Personal breathing zone and area air samples were analyzed for acetone (67641), 2-butoxyethanol (111762), butyl-alcohol (71363), cyclohexanol (108930), petroleum distillates, toluene (108883), and xylene (1330207) concentrations. (cdc.gov)
  • Cyclohexanol undergoes the main reactions expected for a secondary alcohol. (wikipedia.org)
  • Why is phosphoric acid added to the cyclohexanol? (pfeiffertheface.com)
  • The acid used in this experiment is 85% phosphoric acid and the alcohol is cyclohexanol. (pfeiffertheface.com)
  • You had to heat up the cyclohexanol and sulfuric acid so they could react with each other. (stuffintheair.com)
  • In the production of adipic acid, caprolactam, and nylon-6, cyclohexanol is an important intermediate. (stuffintheair.com)
  • Cyclohexanol makes adipic acid, which is used to make nylon, plastics, and other synthetic materials. (stuffintheair.com)
  • The extracted acid is then derivatized with cyclohexanol to form a dicyclohexyl ester. (cdc.gov)
  • As indicated above, cyclohexanol is an important feedstock in the polymer industry, firstly as a precursor to nylons, but also to various plasticizers. (wikipedia.org)
  • Link to all annotated objects annotated to cyclohexanol metabolic process. (planteome.org)
  • Link to all direct and indirect annotations to cyclohexanol metabolic process. (planteome.org)
  • Besides its industrial applications, cyclohexanol has some medicinal properties and is used in some pharmaceuticals. (stuffintheair.com)
  • The chemical name for tramadol hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3methoxyphenyl) cyclohexanol hydrochloride. (nih.gov)
  • As indicated above, cyclohexanol is an important feedstock in the polymer industry, firstly as a precursor to nylons, but also to various plasticizers. (wikipedia.org)
  • The toxicokinetics and metabolism of cyclohexanol were studied in 8 human volunteers (4/sex) exposed by inhalation to 236 mg/m³ cyclohexanol for 8 h. (europa.eu)
  • Synthesis of Cyclohexanol by Three-Phase Catalytic Distillation: Kinetics and Equilibria. (mpg.de)
  • Cyclohexanol administered orally by gavage to rabbits was readily absorbed. (europa.eu)
  • Negligible amounts of cyclohexanol were found in the expired air. (europa.eu)
  • This Skin Notation Profile provides the SK assignments and supportive data for cyclohexanol. (cdc.gov)
  • Succinonitrile-cyclohexanol was chosen because both components are transparent models for metallic solidification, as opposed to the other known succinonitrile-based monotectics. (psu.edu)
  • Binding and molecular dynamic studies of sesquiterpenes (2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)-1t-cyclohexanol) derived from marine Streptomyces sp. (bvsalud.org)