Six-carbon alicyclic hydrocarbons.
Derivatives of BUTYRIC ACID that include a double bond between carbon 2 and 3 of the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.
An anticholesteremic agent that inhibits sterol biosynthesis in animals.
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
A group of PROTEOBACTERIA represented by morphologically diverse, anaerobic sulfidogens. Some members of this group are considered bacterial predators, having bacteriolytic properties.
The sole genus in the family Methanospirillaceae whose organisms are progressively motile by means of polar, tufted flagella. They have been isolated from sewage-sludge and pear waste digesters as well as marine and non-marine habitats.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
Drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
The characteristic three-dimensional shape of a molecule.
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Regulations to assure protection of property and equipment.
Laws and regulations concerned with industrial processing and marketing of foods.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Informed consent given by a parent on behalf of a minor or otherwise incompetent child.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography.
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (1/763)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Increased transcriptional activity of prostate-specific antigen in the presence of TNP-470, an angiogenesis inhibitor. (2/763)

Prostate-specific antigen, PSA, is regarded as a reliable surrogate marker for androgen-independent prostate cancer (AIPC). Concern has been raised that investigational agents may affect PSA secretion without altering tumour growth or volume. In a phase I trial, several patients with AIPC had elevated serum PSA levels while receiving TNP-470 that reversed upon discontinuation. TNP-470 inhibits capillary growth in several angiogenesis models. These observations prompted us to determine if TNP-470, or its metabolite, AGM-1883, altered PSA secretion. Intracellular protein and transcriptional levels of PSA and androgen receptor were also determined. The highest TNP-470 concentration produced a 40.6% decrease in cell number; AGM-1883 had minimal effects on cell viability. PSA secretion per cell was induced 1.1- to 1.5-fold following TNP-470 exposure. The same trend was observed for AGM-1883. PSA and AR were transcriptionally up-regulated within 30 min after exposure to TNP-470. PSA transcription was increased 1.4-fold, while androgen receptor (AR) transcription was induced 1.2-fold. The increased PSA transcriptional activity accounts for the increased PSA secretion. Increased AR transcription was also reflected at the protein level. In conclusion, TNP-470 and AGM-1883 both up-regulated PSA making clinical utilization of this surrogate marker problematic.  (+info)

Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. (3/763)

BACKGROUND: Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the progression of atherosclerosis is unknown. In this report, we first demonstrate that intimal vessels occur in advanced lesions of apolipoprotein E-deficient (apoE -/-) mice. To test the hypothesis that intimal vessels promote atherosclerosis, we investigated the effect of angiogenesis inhibitors on plaque growth in apoE -/- mice. METHODS AND RESULTS: ApoE -/- mice were fed a 0.15% cholesterol diet. At age 20 weeks, mice were divided into 3 groups and treated for 16 weeks as follows: group 1, recombinant mouse endostatin, 20 mg. kg-1. d-1; group 2, fumagillin analogue TNP-470, 30 mg/kg every other day; and group 3, control animals that received a similar volume of buffer. Average cholesterol levels were similar in all groups. Plaque areas were quantified at the aortic origin. Median plaque area before treatment was 0.250 mm2 (range, 0.170 to 0.348; n=10). Median plaque areas were 0.321 (0.238 to 0.412; n=10), 0.402 (0.248 to 0.533; n=15), and 0.751 mm2 (0.503 to 0.838; n=12) for the endostatin, TNP-470, and control groups, respectively (P+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (4/763)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (5/763)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (6/763)

We investigated the effects of a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane), on ACAT activities in macrophages originating from several species and high-density lipoprotein (HDL)-induced cholesterol efflux in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. NTE-122 inhibited cell-free ACAT activities in human PMA-treated THP-1 cells and mouse J774.1 cells with IC50 values of 0.88 and 360 nM, respectively. NTE-122 competively inhibited the ACAT activity in PMA-treated THP-1 cells. NTE-122 also inhibited cellular ACAT activities in PMA-treated THP-1 cells, rat peritoneal macrophages and J774.1 cells with IC50 values of 3.5, 84 and 6800 nM, respectively. Furthermore, NTE-122 prevented cholesterol accumulation in PMA-treated THP-1 cells incubated with acetylated low density lipoprotein, simultaneously with HDL, while it caused accumulation of a significant amount of free cholesterol in the absence and even in the presence of HDL. NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells. These results suggest that NTE-122, capable of inhibiting macrophage ACAT activity in humans more strongly than those in the other species, exhibits anti-atherogenic effects by preventing the foam cell formation and enhancing the foam cell regression in humans.  (+info)

The loss in hydrophobic surface area resulting from a Leu to Val mutation at the N-terminus of the aldehyde dehydrogenase presequence prevents import of the protein into mitochondria. (7/763)

An apparent conservative mutation, Leu to Val, at the second residue of the rat liver mitochondrial aldehyde dehydrogenase (ALDH) presequence resulted in a precursor protein that was not imported into mitochondria. Additional mutants were made to substitute various amino acids with nonpolar side chains for Leu2. The Ile, Phe, and Trp mutants were imported to an extent similar to that of the native precursor, but the Ala mutant was imported only about one-fourth as well. It was shown that the N-terminal methionine was removed from the L2V mutant in a reaction catalyzed by methionine aminopeptidase. The N-terminal methionine of native pALDH and the other mutant presequences was blocked, presumably by acetylation. Because of the difference in co-translational modification, the L2V mutant sustained a significant loss in the available hydrophobic surface of the presequence. Import competence was restored to the L2V mutant when it was translated using a system that did not remove Met1. The removal of an Arg-Gly-Pro helix linker segment (residues 11-14) from the L2V mutant, which shifted three leucine residues toward the N-terminus, also restored import competence. These results lead to the conclusion that a minimum amount of hydrophobic surface area near the N-termini of mitochondrial presequences is an essential property to determine their ability to be imported. As a result, both electrostatic and hydrophobic components must be considered when trying to understand the interactions between precursor proteins and proteins of the mitochondrial import apparatus.  (+info)

Metabolic drug interactions between angiogenic inhibitor, TNP-470 and anticancer agents in primary cultured hepatocytes and microsomes. (8/763)

The potential metabolic drug interactions between TNP-470, a potent inhibitor of angiogenesis, and several commonly used anticancer agents, such as cyclophosphamide, taxol, and minocycline, were investigated in vitro using primary cultured hepatocytes and microsomes of rhesus monkeys. After incubation of hepatocytes with 5 microM [3H]TNP-470, rapid and extensive formation of six metabolites was observed, with M-II and M-IV being the predominant metabolites. After 30 min of incubation in the presence of 250 microM cyclophosphamide, concentrations of unchanged TNP-470 and M-IV were increased with values of 1.00 +/- 0.02 and 1.49 +/- 0.01 microM compared with control values of 0.67 +/- 0.09 (p =.02), 1.39 +/- 0. 03 microM (p <.01), respectively. In contrast, the concentration of M-II was substantially decreased from 1.69 +/- 0.86 to 1.02 +/- 0.16 microM (p =.01). Combination of taxol with TNP-470 led to a 50% decrease of M-II levels (p <.01), whereas unchanged TNP-470 and M-IV levels were increased by at least 2.5-fold compared with control (p =.08 and 0.01). Exposure of cells to TNP-470 with 250 microM minocycline had no effect on TNP-470 metabolism in monkey hepatocytes. In vitro studies with isolated monkey liver microsomes confirmed these drug-drug metabolic interactions detected at the cellular level. A detailed understanding of the potential drug interactions in TNP-470 metabolism occurring with taxol or cyclophosphamide is critical to fully elucidate the potentiation of the antitumor activity observed in vivo after coadministration of these two agents with TNP-470.  (+info)

Cyclohexane Market - Market Overview. Cyclohexane is a colorless and flammable liquid, which is produced by catalytic hydrogenation of benzene. Cyclohexane Market Size is mainly used in the production of adipic acid and caprolactam. These materials are primarily used in manufacturing various thermoplastics, fibers, polyesters, and plasticizers. Cyclohexane is widely used in the manufacturing of nylon-based materials. The nylon-based thermoplastic components are majorly used in automotive light-weighting to increase the fuel-efficiency of the vehicles. The increasing use of nylon-based thermoplastics in manufacturing various automotive parts is likely to boost demand for Cyclohexane during the forecast period. Moreover, the increasing demand for Cyclohexane in the end-use industries such as food & beverages, packaging, textile, building & construction, and paints & coating is anticipated to drive growth of the Global Cyclohexane Market during the assessment period.. Asia-pacific is expected to be ...
The CCR5 antagonist maraviroc (MVC) inhibits human immunodeficiency virus type 1 (HIV-1) entry by altering the CCR5 extracellular loops (ECL), such that the gp120 envelope glycoproteins (Env) no longer recognize CCR5. The mechanisms of HIV-1 resistance to MVC, the only CCR5 antagonist licensed for clinical use are poorly understood, with insights into MVC resistance almost exclusively limited to knowledge obtained from in vitro studies or from studies of resistance to other CCR5 antagonists. To more precisely understand mechanisms of resistance to MVC in vivo, we characterized Envs isolated from 2 subjects who experienced virologic failure on MVC. Envs were cloned from subjects 17 and 24 before commencement of MVC (17-Sens and 24-Sens) and after virologic failure (17-Res and 24-Res). The Envs cloned during virologic failure showed broad divergence in resistance levels, with 17-Res Env exhibiting a relatively high maximal percent inhibition (MPI) of ~90% in NP2-CD4/CCR5 cells and peripheral blood
Principal Investigator:KODAMA Shoji, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Obstetrics and gynecology
Subjects will attend for regular clinic visits during study treatment phase.. On day 15, subjects will attend the unit in the morning prior to usual dosing time. Blood with be drawn to assess plasma maraviroc concentration pre dose and pre lumbar puncture. A lumbar puncture will be performed under standard aseptic techniques to asses CSF maraviroc concentration and routine CSF parameters.. On completion of this study visit, subjects will cease maraviroc, continue on their usual antiretroviral regimen and attend for a follow up visit 10 days later. ...
Adult and adolescent guidelines of the U.S. Department of Health and Human Services state that maraviroc is not recommended for initial treatment of HIV infection. Maraviroc is effective only in persons with exclusively CCR5-tropic HIV. Tropism testing should be performed before initiating treatment with maraviroc, to verify that no CXCR4-tropic virus is present. In previously untreated patients, a randomized controlled study compared maraviroc with efavirenz, each drug being given in combination with zidovudine + lamivudine. All patients had only CCR5-tropic HIV according to the tropism assay available at the time of study entry. At 48 weeks, by intention-to-treat analysis, the maraviroc group had lower rates of virologic suppression to ,50 copies/mL than the efavirenz group (65% vs 69%); this result did not meet the studys criteria for noninferiority of maraviroc.(4) However, researchers later reanalyzed the baseline tropism status of the study subjects using a more sensitive tropism assay ...
Detailed data and modeling of cyclohexane flames establish that a mixture of pathways contributes to benzene formation and that this mixture changes with stoichiometry. Mole-fraction profiles are mapped for more than 40 species in a fuel-rich, premixed flat flame (Φ = 2.0, cyclohexane/O2/30% Ar, 30 Torr, 50.0 cm/s) using molecular-beam mass spectrometry with VUV-photoionization at the Advanced Light Source of the Lawrence Berkeley National Laboratory. The use of a newly constructed set of reactions leads to an excellent simulation of this flame and an earlier stoichiometric flame (M.E. Law et al., Proc. Combust. Inst. 31 (2007) 565-573), permitting analysis of the contributing mechanistic pathways. Under stoichiometric conditions, benzene formation is found to be dominated by stepwise dehydrogenation of the six-membered ring with cyclohexadienyl →benzene + H being the final step. This finding is in accordance with recent literature. Dehydrogenation of the six-membered ring is also found to be a
Shop a large selection of Cyclohexane products and learn more about Cyclohexane, For gas chromatography ECD and FID SupraSolv , MilliporeSigma. Glass Bottle; 1L.
A high shear mechanical device incorporated into a process and system for the production of cyclohexane is capable of decreasing mass transfer limitations, thereby enhancing the cyclohexane productio
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Compound potency: IC50 and MLC determination.Cell viability assays are affected not just by the kinetics of the targeted protein (most likely MetAP2 in this case) but also by additional factors, such as compound permeation across the trophozoite membrane and the susceptibility of the compound to degrading cellular enzymes. These factors also affect compound efficacy in vivo. Additionally, both in vitro and in vivo cell viability may be affected by unknown off-target inhibition. Although the only validated target of fumagillol derivatives is MetAP2, the MetAP2-independent effects of fumagillin on angiogenesis are known (34, 35). As angiogenesis does not exist in G. lamblia, currently, there is no alternative MapAP2-independent activity of fumagillin that could be tested. Nevertheless, the possibility of a contribution of off-target inhibition to the lethal effects of drug candidates cannot be excluded.. Antigiardia assays followed by enzyme inhibition determination facilitated the selection of ...
Maraviroc (UK-427,857), a selective and reversible CCR5 coreceptor antagonist, has been shown to be active in vitro against a wide range of clinical isolates (including those resistant to existing classes). In HIV-1 infected patients, maraviroc (UK-427,857) given as monotherapy for 10 days reduced HIV-1 viral load by up to 1.6 log, consistent with currently available agents. Safety and toleration have been studied in over 400 subjects for up to 28 days at 300 mg twice daily. No significant effects were seen on the QTc interval. The goal of this study is to compare the safety and efficacy of maraviroc (UK-427,857) versus efavirenz, when each are combined with two other antiretroviral agents, in patients who are previously naive to antiretroviral therapy. This study will involve approximately 200 centers from around the world to achieve a total randomized subject population of 1071 subjects. Patients will be randomly assigned to one of three groups: maraviroc (UK-427,857) 300 mg once daily added ...
Other names Hexanaphthene archaic [1]. Cyclohexane has the lowest angle and torsional strain of all the cycloalkanes; as a result cyclohexane has been deemed a 0 in total ring strain. Articles Baeyer-Villiger Oxidation Reaction The.. The molecule Sykloheksanoni of Sitruunahappo Vedenkeitin 44 C c.. Chemical formula. Keywords: Asymmetric synthesis, Catalysis, Oxidations. Sykloheksanoni on normaaliolosuhteissa Pössl 2win olomuodoltaan is produced by hydrogenation of important building block for the asetonia Sykloheksanoni haju.. Yhdistett on mahdollista tuottaa mys alkyl substituent of cyclohexane and. Sykloheksanonin hajukynnys 0,12 ppm, leimahduspiste.. Std molar entropy S o vritnt tai kellertv ljymist nestett benzene in the presence of reactions have been developed for.. On an industrial scale, cyclohexane GND : It is an naisten erilaiset kiinnostuksen kohteet johtavat Lappeenranta Lempl Leppvirta Lieto Lohja.. Certificate of Origin COO. Koronan takia SKA Netfjanik saikin owned holding company ...
Consider a binary mixture of cyclohexane (BP ) and benzene (BP ) at . This mixture presents a minimum-boiling azeotrope. It is possible to break this azeotrope using aniline. The vapor-liquid equilibrium (VLE) behavior of the ternary mixture is described by a modified form of Raoults law with activity coefficients predicted by the Wilson model [1]. This Demonstration plots the pseudo-binary phase;
Rights: This volume was digitized and made accessible online due to deterioration of the original print copy. If you are the author of this work and would like to have online access removed, please contact the Library Administration Office, 785-532-7400, [email protected] ...
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The reproduction and developmental toxicity of Cyclohexane, 1,4-bis[(ethenyloxy)methyl]-(1,4-Cyclohexandimethanoldivinylether) was tested according to OECD TG 421 (BASF SE, 2010). Male and female Wistar rats received single daily oral doses of 40, 200 and 1000/600 mg/kg bw over a period covering 2 week of premating, mating, approximately 1 week post-mating for the males, and the entire gestation period and 4 days of lactation for the females. Clinical observations indicating distinct toxicity lead to a reduction of the high dose from 1000 to 600 mg/kg bw/d from the fourth administration onwards. At necropsy (after 4 weeks for the males; at the end of the lactation period of 4 days for the females), the animals were subjected to gross pathology, organ weighing and histopathology; particular attention was given to the reproduction organs. Referring to the pups, all of them were examined, weighed and counted; check for dead or moribund pups was made until day 4 post parturition. Sex ratio was ...
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CYCLOHEXANE | C6H12 | CID 8078 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Thanks for your reply. The vessel is not closed and the vapours once formed will be condensed using a seperate condenser. In fact I was trying to find IR curve for cyclohexane in the range of 30000 to 60000 cm-1 wave number. Unfortunately i could not get one . If you find any IR curve in that range please do communicate ...
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Cyclohexane,1-bromo-2-(bromodifluoromethyl)-/ACM14737098 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Maraviroc - Get up-to-date information on Maraviroc side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Maraviroc
The magnitude or intensity of nmr resonance signals is displayed along the vertical axis of a spectrum, and is proportional to the molar concentration of the sample. Thus, a small or dilute sample will give a weak signal, and doubling or tripling the sample concentration increases the signal strength proportionally. If we take the nmr spectrum of equal molar amounts of benzene and cyclohexane in carbon tetrachloride solution, the resonance signal from cyclohexane will be twice as intense as that from benzene because cyclohexane has twice as many hydrogens per molecule. This is an important relationship when samples incorporating two or more different sets of hydrogen atoms are examined, since it allows the ratio of hydrogen atoms in each distinct set to be determined. To this end it is necessary to measure the relative strength as well as the chemical shift of the resonance signals that comprise an nmr spectrum. Two common methods of displaying the integrated intensities associated with a ...
You may also wish to search for items by Kawamura. 3 matching references were found. Nagata, I.; Kawamura, Y.; Ogasawara, Y.; Tokuriki, S., Excess enthalpies of chloroform + cyclohexane, propanol-2-ol + toluene + cyclohexane and propan-2-ol + chloroform + cyclohexane at 298.15 k, J. Chem. Thermodyn., 1980, 12, 223-8. [all data] Nagata, I.; Kawamura, Y., Excess thermodynamic functions and complex formation in binary liquid mixtures containing acetonitrile, Fluid Phase Equilib., 1979, 3, 1-11. [all data] Nagata, I.; Kawamura, Y.; Asano, H.; Fujiwara, K.; Ogasawara, Y., Excess enthalpies for binary mixtures of chloroform with alcohols., Z. Phys. Chem. (Leipzig), 1978, 259, 1109-16. [all data] ...
Nateglinide is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas. Nateglinide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with nateglinide if...
10) Randall, L.P., Clouting, C.S., Gradel, K.O., Clifton-Hadley, F.A., Davies, R.D., Woodward, M.J. (2005): Farm disinfectants select for cyclohexane resistance, a marker of multiple antibiotic resistance, in Escherichia coli ...
The purpose of this proof of concept, pilot study is to determine whether the unique combination of the human immunodeficiency virus (HIV) co-receptor
Phenol deoxygenation has been investigated as a model reaction for the deoxygenation of fatty acid methyl esters in biodiesel. Hydrodeoxygenated biodiesel is a drop-in fuel for petroleum diesel, and is a premium diesel with a high cetane number. As the first step in this research, two molybdenum catalysts were prepared, characterized and tested in a small-scale reactor. These catalysts were found to produce small amounts of benzene and cyclohexanol in the product stream, and confirmed the activity of the catalyst. A commercial cobalt molybdenum catalyst (Harshaw HT-400) was also tested and benzene, cyclohexanol, and cyclohexane were identified as products. Future work aims to synthesize catalysts to produce a high yield of cyclohexane. Once the conditions are optimized, we will do tests with biodiesel.
As this eMedTV page explains, the starting dose of nateglinide is generally 120 mg, taken before each meal. However, the nateglinide dosing amount may be lower based on certain blood sugar tests. This page also offers some tips on taking the drug.
If youre interested in finding where to buy nateglinide 60 mg in AU, then our pharmacy is about to offer you the very favorable conditions for purchasing medicines without a prescription. Patients successfully use nateglinide for the treatment of diseases explained in the manual below. Our online pharmacy provides fast delivery throughout Australia. Buy and make sure of the high caliber of our services. Since we promote absolutely all medicines without a prescription, carefully read all the contraindications, side effects and interactions with other medications. In any case, we advise you to consult with your doctor.. ...
then go ahead and pursue the treatment. Nateglinide Alkalosis reduces the level of ionizable serum calcium. Apply the cream thinly over the rashes, Thats more people than died in BOTH world wars put together. is one such problem and as a remedy it requires both medication and medical treatment ...
Step by step tutorial for drawing the cyclohexane hexagon, chair conformations, and cyclohexane ring flip as required in your standard organic chemistry course. This tutorial includes a few tricks to simplify the process and simplify the chair analysis
Step by step tutorial for drawing the cyclohexane hexagon, chair conformations, and cyclohexane ring flip as required in your standard organic chemistry course. This tutorial includes a few tricks to simplify the process and simplify the chair analysis
1,1-Di-(tert.butylperoxy)-cyclohexane (CAS 3006-86-8) Market Research Report 2018 aims at providing comprehensive data on 1,1-di-(tert.butylperoxy)-cyclohexane
(E)-4-Pentyl-(4-cyanophenyl)-cyclohexane (CAS 61204-01-1) Market Research Report 2018 aims at providing comprehensive data on (e)-4-pentyl-(4-cyanophenyl)-cyclohexane
Nateglinide (INN, trade name Starlix) is a drug for the treatment of type 2 diabetes. Nateglinide was developed by Ajinomoto, a Japanese company and sold by the Swiss pharmaceutical company Novartis. Nateglinide belongs to the meglitinide class of blood glucose-lowering drugs. Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the β cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs. Nateglinide is contraindicated in patients who: have known hypersensitivity to the compound or any ingredient in the formulation. are affected with type 1 (namely insulin-dependent) diabetes mellitus. are in diabetic ketoacidosis. A study funded by Novo Nordisk, the U.S. distributor for Repaglinide, compared their product with ...
Introduction: Pulmonary hypertension (PH) is a chronic lung disease that leads to right ventricular (RV) failure. Recently we found that estrogen (E2) can rescue severe PH. As E2 has anti-inflammatory activity in a variety of diseases and promotes angiogenesis in different tissues, we investigated whether the stimulation of angiogenesis and suppression of inflammation in the heart and lungs are the key players in E2-induced rescue of PH.. Methods: Male rats were treated with a s.c. dose of monocrotaline (MCT, 60 mg/kg) to induce PH (n=28). At day 21 when PH was established, one group was euthanized (MCT, n=8), 2 other groups received either E2 (0.017 mg/day, n=11) or E2 plus angiogenesis inhibitor TNP-470 (1.2 mg/day, n=3) for 10 days. Saline treated rats were control (CTRL, n=5). All animals were sacrificed at day 31 except for 6 E2 rats that were followed until day 42. Real time PCR, Western Blot and immunohistology were performed. Values were mean±SE. P,0.05 was significant.. Results: E2 ...
0115] This Example describes the derivatization of glass plates with an exemplary alkenyl linker (C8). Microscope cover/slide glass plates and microarray plates containing multiple sites were treated with hot piranha solution (concentrated H2SO4:H2O2, 50:50 v/v) for 15 min. The cleaned surface was thoroughly rinsed with H2O, acetone, CH2Cl2, then cyclohexane, and dried. The plates were placed in a sealable container containing 5 mM 7-octenyltrimethoxysilane, (FIG. 2, CH2═CH(CH2)6Si(OCH3)3) in cyclohexane or 5 mM docosenyltriethoxysilane (FIG. 2, CH2═CH(CH2)20Si(OCH2CH3)3) in 4:1 cyclohexane:CHCl3. The reaction was left at room temperature with gentle shaking for 16 h. Upon completion of the reaction, glass plates were rinsed thoroughly with cyclohexane and cured at 100° C. under N2 for 1 h. The derivatized glass plates were placed in a 10 mL glass vial closed by a septum, separated by Teflon sheets. The container was purged with N2 for 10 min, and 5 mL of 1 M BH3.THF was introduced using N2 ...
The metabolic oxidation of the cyclohexane ring of t-butylcyclohexane preferentially occurred at the 4-position. The bulkiness of the t-butyl group apparently inhibited monooxidation at the 2- and 3-positions. Both cis- and trans-4-t-butyl- cyclohexanol are formed with the latter being the overall principle metabolic product. The remaining minor metabolites identified were the result of dioxidation on the cyclohexane ring at the 3-position. The least formed cyclohexanediol was the isomer in which all the ring substituents exist in the equatorial position of the cyclohexane chair conformation of 2- hydroxy-4-t-butylcyclohexanol. 2-Hydroxy-4-t-butylcyclohexanol has the t-butyl and the OH at C1 groups in the equatorial position, while the OH at C2 is in the axial position. The most abundant cyclohexanediol, 2-hydroxy-4-t-butylcyclohexanol, has the OH at C2 and the t-butyl groups in the equatorial positions while the OH at C1 is in the axial position. If one envisions that the starting materials for ...
Iodine solubility. Test tube with a mixture of water, cyclohexane and iodine. The iodine has dissolved in cyclohexane, a non-polar solvent, to form a purple solution. Iodine does not readily dissolve in water, a polar solvent. As water and cyclohexane are immiscible (will not mix), the two solutions have separated to form two distinct layers. - Stock Image A700/0201
Aim: Creation of a BioBrick for the expression of both the alpha and beta subunits of prefoldin. A medium-transcription level promoter as well as a medium-translation level ribosomal binding site is utilized. Before any design, we checked on literature about reports related to solvent/hydrocarbon tolerance. The paper published by Okochi and co-workers caught our attention up, according to their paper E. coli expressing prefoldin from Pyrococcus horikoshii OT3 grows quite well in the presence of high concentrations (10%v/v) of cyclohexane. Cyclohexane causes membrane leaking and other toxic effects, which makes it a good candidate for testing solvent/hydrocarbon tolerance. The original prefoldin alpha and prefoldin beta DNA sequences differ in composition from the E. coli sequences and also contained some undesired restriction sites, thats why we decided to enhance our sequence for a successful expression on E. coli, for that purpose we used jcat website. Once we had the enhanced sequence, we ...
These results show the dynamical nature of the quenching process; i.e. the quenching is due to the excited state interaction of AC with the amine. The mean value of the quenching constant obtained from Stern-Volmer plots of the steady-state and time-resolved fluorescence data, 5x1010 M-1 s-1, is similar to those of the quenching constants, kq, reported in Table 1 for the AC-DMF and AC-DMA systems. These quenching constants are, on the other hand, of the order of magnitude expected for a difussion controlled process in cyclohexane. Conversely, the changes observed in the absorption and fluorescence spectra of AC in cyclohexane upon the addition of methylethylcetone entirely resemble those produced by the amides.. On the basis of the above results, we conclude that, in the ground state, the pyrrolic NH group of AC interacts preferently with the carbonyl groups of the amides, but, in the excited state, the hydrogen-bonding interactions take place through the lone electron pair of the nitrogen atoms ...
Chemical formula C 6 H 12 Molar mass: 84 16 g/mol Density: 0 779 g/ml liquid Melting point: Boiling point: Viscosity: 1 02 cP at 17 C Thermochemistry Std enthalpy of formation Δ f H o 298-156 kJ/mol Std enthalpy of combustion Δ c H o 298-3920 kJ/mol Hazards EU classification {{{value}}} R-phrases: R11 R38 R65 R67 S-phrases (S2) S9 S16 S25 S33 S60 S61 S62: Flash point {{{value Continue Reading ...
Go To: Top, Gas Chromatography, References, Notes. Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved. Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. Note: Please consider using the reaction search for this species. This page allows searching of all reactions involving this species. A general reaction search form is also available. Future versions of this site may rely on reaction search pages in place of the enumerated reaction displays seen below. ...
From Jules: several researchers at the Sitges meeting expressed their opinion that having to perform a test to screen for use of this drug would prevent doctors from using it, this is similar to the situation with the Tropism Trofile assay where doctors sometimes do not want to bother using the assay. The company Panacos also said they have backup drugs in development with perhaps better formulation profiles. Apparently, the drug may be useful for patients, particularly drug-resistant patients, so if an assay can be used to identify patients in which it will help I am astounded that doctors would not bother to use it. I am also astounded that doctors will not use Maraviroc because they would have to take the time to use a screening assay, the Trofile assay. It is clear that you should not use Maraviroc without performing the Trofile assay to identify if the patient is CCR5 tropic or not. It is also clear that some treatment-experienced patients need to use Maraviroc to achieve undetectable viral ...
Objective: Receptive anal intercourse in both men and women is associated with the highest probability for sexual acquisition of HIV infection. As part of a program to develop an effective prevention strategy, we performed an ex-vivo preclinical evaluation to determine the efficacy of multiple double combinations of maraviroc (MVC) and reverse transcriptase inhibitors (RTIs). Design: The entry inhibitor, MVC, a nucleotide RTI, tenofovir and two non-nucleoside RTIs, UC781 and TMC120 (dapivirine, DPV), were used in double, combinations against a panel of CCR5-using clade B and clade C HIV-1 isolates and against MVC-escape variants. A gel-formulated version of MVC-DPV combination was also tested. Methods: Indicator cells, cocultures of immature dendritic cells with CD4+T cells, and colorectal tissue explants were used to assess antiviral activity of drug combinations. Results: All dual MVC-RTI combinations tested inhibited MVC-sensitive and resistant isolates in cellular and colorectal explants ...
Roche M, Salimi H, Duncan R, Wilkinson BL, Chikere K, Moore MS, Webb NE, Zappi H, Sterjovski J, Flynn JK, Ellett A, Gray LR, Lee B, Jubb B, Westby M, Ramsland PA, Lewin SR, Payne RJ, Churchill MJ, Gorry PR (2013). A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology, ...
Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. . 2010 Aug; 54(5):470-6 ...
Pfizers antiretroviral drug maraviroc can reduce HIV viral loads among people who have never taken antiretrovirals, the company announced on Wednesday, ...
The IUPHAR/BPS Guide to Pharmacology. maraviroc ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
The IUPHAR/BPS Guide to Pharmacology. maraviroc ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
If Approved, Maraviroc will be the First in a New Class of Medications Available for HIV Treatment Pfizer announced today that marketing authorization applicati
s-[(3s)-3-methyl-1-cyclohexen-1-yl] ester c11h19nos (cas 255851 , 宽300x300高 , 显示比例:100% , 查看原图 , 图片来源 ...
2-(1-cyclohexen-1-yl)-2-methylpropanoic acid - chemical structural formula, chemical names, chemical properties, synthesis references
In a double-blind, randomized clinical trial, we assigned 9306 participants with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors to receive nateglinide (up to 60 mg three times daily) or placebo, in a 2-by-2 factorial design with valsartan or placebo, in addition to participation in a lifestyle modification program ...
Starlix Tablet (Nateglinide) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
Each carbon atom has a hydrogen attached to it. One of the reasons for benzenes ubiquity is its unusual ring structure first discovered by Kekulé in 1865. Cyclic Structure. Newsiest Representation contract sample. The Kekulé structure, according to August Kekulé himself, came to him in a day-dream when he saw a snake seizing its own tail forming a ring structure. He was actually solving a chemistry problem and day-dreaming. Carbon Ring Structure. structure oscillated between the two Kekulé forms but was represented by neither of them. Note: Pressure values quoted can be anywhere from about 20 atmospheres to 200 atmospheres.I have no way of knowing which is right! Pdf. Kekuléâ s 1890 lecture asserts that his benzene structure emerged from a second dream, featuring a serpent biting its tail. The structures of cyclohexene and cyclohexane are usually simplified in the same way that the Kekulé structure for benzene is simplified - by leaving out all the carbons and hydrogens. The Kekulé ...
Reyes, E.; Jiang, H.; Milelli, A.; Elsner, P.; Hazell, R. G.; Jorgensen, K. A. How to Make Five Contiguous Stereocenters in one Reaction: Asymmetric Organocatalytic Synthesis of Pentasubstituted Cyclohexanes Angew. Chem. Int. Ed. 2007, 46, 9202-9205. (Highlighted in Synfacts 2008, 89). (Post-doc E.R ...
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Freezing of pure and salt water - Melting of pure water and cyclohexane - Characteristics of temperature during a change of state
MVC Cave of about 75ng/mL is associated with 80% probability of a successful response (with Combivir) in treatment-naive subjects with other favorable prognostic factors (not shown)...... Population PK modeling of all MVC PK data from MERIT (including discontinued QD/open label subjects), showed that at least 87% of subjects if given MVC 300mg BID (without drug interactions) would have achieved this average concentration. However, low exposure may be a surrogate for poor adherence. Many (17/46) in the group with Cave less than 75ng/mL had MVC concentrations BLQ on at least one occasion. Such low concentrations are highly unlikely in subjects taking 300mg MVC BID based on modeling of phase 1/2a data with observed dosing. ...
It usually is obtained as a mixture with cyclohexane. It is mainly converted in naphthene reformers to benzene. The C6 core of ... ISBN 978-1-4200-6679-1. M. Larry Campbell (2012). "Cyclohexane". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: ...
cyclohexane, 12. toluene. Bacillus subtilis stained with Nile red as a membrane dye (shown in red). This strain grows partly as ...
Derivatives of cyclohexane. American Chemical Journal 43(5): 412-417. Kohler, E. P., G. L. Heritage, M. C. Burnley (1910) The ...
More alkane conformations exist in cyclic alkanes; see cyclohexane conformations. More on the impact of gauche interactions; ...
When cyclohexane is exposed to radiation, bicyclohexyl is produced among other hydrocarbons. The molecule is not completely ... Nixon, A. C.; Thorpe, R. E. (May 1958). "Radiation Chemistry of Cyclohexane". The Journal of Chemical Physics. 28 (5): 1004- ... it slowly decomposes to cyclohexane and cyclohexene, as the pivot bond joining the two rings is the longest and weakest one. ... Its structure consists of two cyclohexane rings joined by a single carbon-carbon bond. Carbazole can be denitrogenated by ...
Part I. Spiro-Compounds from cyclohexane". J. Chem. Soc., Trans. 107: 1080-1106. doi:10.1039/CT9150701080. Shaw, B. L. (1975 ...
cycloPentane, cyclohexane, cycloheptane, and some derivatives. The multiplanar structure of the methylcyclohexane ring (J. Chem ... Part I. ββ-Dimethylglutaric, cyclopentane- and cyclohexane-1 : 1-diacetic acids, and the mechanism of the reaction (J. Chem. ...
Cyclohexane is used as a solvent. The reaction is a metalation followed by a cyclization. The reaction product is then cooled, ...
A values are derived from equilibrium measurements of monosubstituted cyclohexanes. The extent that a substituent favors the ...
Marco-Contelles, J; Molina, Maria T.; Anjum, S (2004). "Naturally Occurring Cyclohexane Epoxides: Sources, Biological ... "The conversion of carbohydrate derivatives into functionalized cyclohexanes and cyclopentanes". Chem. Rev. 93 (8): 2779-2831. ...
It is the carboxylic acid of cyclohexane. It is a colorless oil that crystallizes near room temperature. It is prepared by ...
Other cyclohexane-based alcohols can also be used. MCHM has the advantage of being less toxic than previous frothing agents ... Epimeric alcohols of the cyclohexane series. Part II. 4-Methyl- and 4-isopropyl-cyclohexyl-1-carbinols". Journal of the ... groups on the cyclohexane ring. Commercial samples of MCHM consists of a mixture of these isomers as well as other components ... cyclohexane methanol, CAS 13828-37-0) is regarded as a flavoring and fragrance agent, sometimes listed under the synonym p- ...
... cyclohexane. This is because of the compounds increased lipophilicity. The act of changing a drug's duration of action through ...
Like all cyclohexanes, it can interconvert rapidly between two chair conformers. The lowest energy form of this monosubstituted ... "Cyclohexane" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2012. doi:10.1002/14356007.a08_209.pub2 ... Methylcyclohexane is a monosubstituted cyclohexane because it has one branching via the attachment of one methyl group on one ...
It was first prepared by the free-radical reaction of cyclohexane using carbon disulfide as a sulfur source. It is produced ... The Introduction of a Mercaptan Group into Cyclohexane". J. Am. Chem. Soc. 63 (2): 625. doi:10.1021/ja01847a508. Kathrin-Maria ...
Figure 8 shows SAR for aminoalkyl cyclohexane derivative. Memantine has several important features in its structure for its ... Memantine (1-amino-3,5-dimethyladamantane) is an aminoalkyl cyclohexane derivative and an atypical drug compound with non- ... modulator An example of memantine derivative is neramexane which was discovered by studying number of aminoalkyl cyclohexanes, ...
Sur la configuration de cyclohexane‐tétrols et ‐triols optiquement actifs. Sur l'oxydation biochimique du cyclohexane‐tétrol‐1, ... Sur quelques cyclohexane‐tétrols‐1,2,3,4". Helvetica Chimica Acta, volume 36, issue 1, pages 251-259. doi:10.1002/hlca. ... 1,2,3,4-Cyclohexanetetrol (also named cyclohexane-1,2,3,4-tetrol, 1,2,3,4-tetrahydroxycyclohexane, or ortho-cyclohexanetetrol) ... 4-diepoxy-cyclohexane. They separated the reaction products into two isomers, with melting points 210C (tetrabenzoate: 146C) ...
Cyclohexane Hofmann, August Wilhelm Von (1 January 1867). "I. On the action of trichloride of phosphorus on the salts of the ...
It is a cyclohexane ring functionalized with an alcohol, specifically a hydroxymethyl group. The compound is a colorless liquid ... This process also give cyclohexane, resulting from hydrogenation. The resulting cyclohexanecarboxaldehyde is then hydrogenated ...
... prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair ...
It is prepared from the triscarbamate of cyclohexane. The latter is generated via the Curtius rearrangement starting from ...
Conformations of the cyclohexane molecule with all six carbon atoms on the same plane have a higher energy, because some or all ... For example, the two conformations of cyclohexane convert to each other quite rapidly at room temperature (in the liquid state ... For example, in the cyclic alcohol inositol ( CHOH ) 6 {\displaystyle {\ce {(CHOH)6}}} (a six-fold alcohol of cyclohexane), the ... Chirality (chemistry) Cis-trans isomerism Cyclohexane conformation Electromerism Isomery (botany) Ligand isomerism Nuclear ...
... can be synthesized by fluorination of cyclohexane. Perfluorocyclohexane is chemically inert and thermally ...
This allows for the commensal growth of Pseudomonas on cyclohexane. The latter can metabolize cyclohexanol, but not cyclohexane ... Accidentally, this enzyme also oxidizes, at no additional cost for M. vaccae, cyclohexane into cyclohexanol. Thus, cyclohexane ...
Sur la configuration de cyclohexane‐tétrols et ‐triols optiquement actifs. Sur l'oxydation biochimique du cyclohexane‐tétrol‐1, ... Sur quelques cyclohexane‐tétrols‐1,2,3,4". Helvetica Chimica Acta, volume 36, issue 1, pages 251-259. doi:10.1002/hlca. ... G. Mehta, S. Sen and S. Dey (2005). "(1S*,2S*,4S*,5S*)-Cyclohexane-1,2,4,5-tetrol monohydrate". Acta Crystallographica, volume ... 1,2,4,5-Cyclohexanetetrol (also named cyclohexane-1,2,4,5-tetrol, 1,2,4,5-tetrahydroxycyclohexane, or para-cyclohexanetetrol) ...
Solvents include dichloromethane, nitromethane, carbon tetrachloride, cyclohexane, trichlorofluoromethane. It is probably ...
Danysz W, Parsons CG, Jirgensons A, Kauss V, Tillner J (2002). "Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA ...
... and cyclohexane have a similar structure, only the ring of delocalized electrons and the loss of one hydrogen per ... Cyclohexane consumes around 10% of the world's benzene production; it is primarily used in the manufacture of nylon fibers, ... Via hydrogenation, benzene and its derivatives convert to cyclohexane and derivatives. This reaction is achieved by the use of ... Benzene is used mainly as an intermediate to make other chemicals, above all ethylbenzene, cumene, cyclohexane, nitrobenzene, ...
B. petroleovorans has the ability to degrade cyclohexane and aromatic compounds such as toluene and m-cresol. "Isolation ... doi:10.1016/S0378-1097(03)00655-4. "Isolation ofBrachymonas petroleovoransCHX, a novel cyclohexane-degrading β-proteobacterium ... ofBrachymonas petroleovoransCHX, a novel cyclohexane-degrading β-proteobacterium". FEMS Microbiology Letters. 227: 101-106. ...
Trower MK, Buckland RM, Higgins R, Griffin M (1985). "Isolation and Characterization of a Cyclohexane-Metabolizing Xanthobacter ...
Cyclohexane. CAS No: 110-82-7. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references include ... Cyclohexane. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Notice: Except where noted, spectra from this collection were measured on dispersive instruments, often in carefully selected solvents, and hence may differ in detail from measurements on FTIR instruments or in other chemical environments. More information on the manner in which spectra in this collection were collected can be found here. Notice: Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived. ...
Benzene hexahydride, Hexahydrobenzene, Hexamethylene, Hexanaphthene Colorless liquid with a sweet, chloroform-like odor. [Note: A solid below 44°F.]
This chapter provides the diffusion coefficient of benzene in cyclohexane at different concentrations measured using Taylor ... Winkelmann J. (2018) Diffusion coefficient of benzene in cyclohexane. In: Lechner M.D. (eds) Diffusion in Gases, Liquids and ... This chapter provides the diffusion coefficient of benzene in cyclohexane at different concentrations measured using Taylor ...
See Also: Toxicological Abbreviations CYCLOHEXANE (JECFA Evaluation) ...
This chapter provides the diffusion coefficient of methyl-cyclohexane in heptan-1-ol at different concentrations measured using ... Winkelmann J. (2018) Diffusion coefficient of methyl-cyclohexane in heptan-1-ol. In: Lechner M.D. (eds) Diffusion in Gases, ... This chapter provides the diffusion coefficient of methyl-cyclohexane in heptan-1-ol at different concentrations measured using ...
This successful company hoses the three largest cyclohexane plants in... ... Introduction Chevron Phillips Chemical Company is the major producer of Cyclohexane. ... 2. Quantity of cyclohexane recovered is not enough to meet the current demand since the cyclohexane content of naphtha is about ... According to ICIS, cyclohexane is used in the production of adipic acid used to…show more content…. Benzene, hydrogen and ...
Cyclohexane *Cyclohexane (8CI, 9CI) *Cyclohexane HP 99,9 *Hexahydrobenzene *Hexamethylene *Hexanaphthene *not applicable ... Cyclohexane EC Number:. 203-806-2. EC Name:. Cyclohexane. CAS Number:. 110-82-7 Molecular formula:. C6H12 IUPAC Name:. ... CyclohexaneCyclohexane. CAS Number:. 110-82-7. Molecular formula:. C6H12. IUPAC Name:. ... CyclohexaneCyclohexane. CAS Number:. 110-82-7. Molecular formula:. C6H12. IUPAC Name:. ...
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Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
The trusted and reliable Cyclohexane report provides unbiased price assessments and a thorough market overview on all the ... About Cyclohexane. Cyclohexane (CX) is a colourless mobile liquid with a mild etheral odour. It is flammable and immiscible ... Cyclohexane news and market information products from ICIS. We offer the following regional Cyclohexane analysis and news ... Cyclohexane Methodology. The major outlet for cyclohexane is in the production of intermediates such as adipic acid, ...
vinyloxy)cyclohexane. Regulatory process names 1 CAS names 1 IUPAC names 3 Trade names 2 Other identifiers 3 ...
4-Disubstituted Cyclohexanes Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and ...
Unless specified otherwise, MP Biomedicals products are for laboratory research use only, not for human or clinical use. For more information, please contact our customer service department ...
4-Disubstituted Cyclohexanes at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances ...
Use the ICIS price assessments and market coverage to track the Cyclohexane US market. ... Understand ICIS coverage of the Cyclohexane US market. ... Cyclohexane Methodology. The major outlet for cyclohexane is in ... Cyclohexane news and market information products from ICIS. We offer the following regional Cyclohexane coverage to keep you ... The US cyclohexane market came down in Q4, following direction from the feedstock benzene market. The cyclohexane prices had ...
If the ring atoms of cis-1,2-dichlorocyclohexane were planar the molecule would have a plane of symmetry and be achiral. The chair conformations, however, are chiral. The two chair conformers shown here are the result of chair-interconversions, and are enantiomers. By moving them about, you should be able to see that they are mirror image configurations and are not identical (ie. superimposable). Because of their mirror image relationship, they have identical energy and are present in equal amounts. This is essentially a racemic mixture of enantiomeric conformers, and its optical activity is zero. The spacefilling rendering shows how the axial chlorine (A) is crowded by the two axial hydrogens on the same side of the ring. The equatorial chlorine (E) is much less crowded ...
... and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory SAR studies led to the cis- ... Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists J Med Chem. 2008 Feb 28;51(4):721 ... We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory ...
Cyclohexane; find Supelco-102817 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma- ... Cyclohexane for gas chromatography ECD and FID SupraSolv®; CAS Number: 110-82-7; Synonyms: Hexahydrobenzene, Hexamethylene, ...
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Similar Discussions: Transmittance of Cyclohexane * Representing Chiral cyclohexane on a chair conformation (Replies: 1) ... In fact I was trying to find IR curve for cyclohexane in the range of 30000 to 60000 cm-1 wave number. Unfortunately i could ... Cant help with IR (I would start finding the expected wavelength and comparing it with the IR spectra for cyclohexane, no idea ... I am interested to know whether cyclohexane will transmit the IR radiation to pass through the quartz viewport upto the ...
Cyclohexane-Based Liquid-Biphasic Systems for Organic Electrochemistry , IntechOpen, Published on: 2012-11-21. Authors: Yohei ... 2. Cyclohexane-based liquid-biphasic systems. Figure 4. Thermomorphic property of cyclohexane in combination with nitromethane ... For this purpose, cyclohexane-based liquid-biphasic systems are powerful. The less-polar cyclohexane phase does not have ... 2. Cyclohexane-based liquid-biphasic systems. Cyclohexane-based liquid-biphasic systems have their roots in the initial ...
SYMMETRY PM7 Cyclohexane HR=CATCH H=-29.49 I=10.3 IR=LLNBS82 XX 0.00000000 +0 0.0000000 +0 0.0000000 +0 0 0 0 XX 5.00000000 +0 ...
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Cyclohexane. Avalara LandedCosts helps determine your duty rates and other import taxes for Uruguay. ...
... often complain they are terrible at drawing organic chemistry structures especially chair conformations of the cyclohexane ... Method 2 for Drawing Cyclohexane Rings. The second method makes use of the fact it is made up of three sets of parallel lines. ... Method 1 for Drawing Cyclohexane Rings. Step 1. Start with a pair of lines drawn in pencil as guides. Draw a triangle as shown ... Cyclohexane Rings. Written by tutor Heidi R.. Students often complain they are terrible at drawing organic chemistry structures ...
Dimethyl cyclohexane-1,2-dicarboxylate; CAS Number: 1687-29-2; find Apollo Scientific Ltd-APOH0680A670 MSDS, related peer- ...
trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 ...
  • The combination of a commercial iron-complex catalyst (ferrocene) and well-adjusted unconventional reaction conditions led to a highly selective, fast and reusable catalytic system for the mild oxidation of cyclohexane. (eurekalert.org)
  • Luísa Martins and Ana Ribeiro, Instituto Superior de Engenharia de Lisboa and Instituto Superior Técnico, Lisbon, Portugal, have developed a method for the oxidation of cyclohexane with tert-butyl hydroperoxide (70% aqueous solution) in the eco-friendly phosphonium ionic liquid medium, [P6.6.6.14][DCA], and in the presence of catalytic amounts of ferrocene at room temperature. (eurekalert.org)
  • An efficient room temperature catalyzed oxidation of cyclohexane to cyclohexanone (K) and cyclohexanol (A) was achieved over hetero-mixed tungsten-vanadia (WO(sub3)/V(sub2)O(sub5)) using H(sub2)O(sub2) oxidant. (csir.co.za)
  • Oxidation of cyclohexane in air produces cyclohexanone and c yclohexanol in cyclopol-bis process along with waste water stream containing valuable carboxylic acids. (niscair.res.in)
  • Highly efficient light-driven HNO3 nitration-oxidation of cyclohexane to co-product. (deepdyve.com)
  • Yin, Dulin 2015-04-10 00:00:00 Co-production of nitrocyclohexane and adipic acid by light-driven nitric acid (HNO3) nitration-oxidation of cyclohexane in an aqueous biphasic system was designed as a potential method for safe synthesis, because the reaction can be carried out at mild conditions (1 atmosphere, 298 K, and solvent-free media). (deepdyve.com)
  • Nitration-oxidation of cyclohexane is initiated by an ·OH from the direct photolysis of nitric acid. (deepdyve.com)
  • Assessment of the nuclear pore dilating agent trans-cyclohexane-1,2-diol in differentiated airway epithelium. (cfgenetherapy.org.uk)
  • Trans-cyclohexane-1,2-diol (TCHD) is an amphipathic alcohol that has been shown to collapse nuclear pore cores and allow the uptake of macromolecules that would otherwise be too large for nuclear entry. (cfgenetherapy.org.uk)
  • Trimethylsilyl (TMS) derivatives of cyclohexane carboxylate, cyclohex-1-ene carboxylate, benzoate, pimelate, glutarate, 3-hydroxybutyrate, and acetoacetate were detected as intermediates by comparison of retention times and mass spectral profiles to authentic standards. (asm.org)
  • With [U- 13 C]crotonate, the m/z -15 ion of TMS-derivatized glutarate, 3-hydroxybutyrate, and acetoacetate each increased by +4 mass units, and the m/z -15 ion of TMS-derivatized pimelate, cyclohex-1-ene carboxylate, benzoate, and cyclohexane carboxylate each increased by +6 mass units. (asm.org)
  • With [ 13 C]sodium bicarbonate and unlabeled crotonate, the m/z -15 ion of TMS derivatives of glutarate, pimelate, cyclohex-1-ene carboxylate, benzoate, and cyclohexane carboxylate each increased by +1 mass unit, suggesting that carboxylation occurred after the synthesis of a four-carbon intermediate. (asm.org)
  • The metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by " Syntrophus aciditrophicus " in cocultures with hydrogen-using microorganisms was studied. (asm.org)
  • Cyclohexane carboxylate, cyclohex-1-ene carboxylate, pimelate, and glutarate (or their coenzyme A [CoA] derivatives) transiently accumulated during growth with benzoate. (asm.org)
  • 13 C nuclear magnetic resonance spectroscopy confirmed that cyclohexane carboxylate and cyclohex-1-ene carboxylate were produced from [ ring - 13 C 6 ]benzoate. (asm.org)
  • Cocultures of " S. aciditrophicus " and Methanospirillum hungatei readily metabolized cyclohexane carboxylate and cyclohex-1-ene carboxylate at a rate slightly faster than the rate of benzoate metabolism. (asm.org)
  • In addition to cyclohexane carboxylate, pimelate, and glutarate, 2-hydroxycyclohexane carboxylate was detected in trace amounts in cocultures grown with cyclohex-1-ene carboxylate. (asm.org)
  • Cyclohex-1-ene carboxylate, pimelate, and glutarate were detected in cocultures grown with cyclohexane carboxylate at levels similar to those found in benzoate-grown cocultures. (asm.org)
  • Surprisingly, their cyclohexanes boiled higher by 10 °C than either hexahydrobenzene or hexanaphtene, but this riddle was solved in 1895 by Markovnikov, N.M. Kishner, and Nikolay Zelinsky when they reassigned "hexahydrobenzene" and "hexanaphtene" as methylcyclopentane, the result of an unexpected rearrangement reaction. (wikipedia.org)
  • The trans-2-o-tolyl, trans-2-p-tolyl and cis-2-p-tolyl derivatives of cyclohexamine hydrochloride and six other cyclohexane derivatives were tested for their effects on intact anesthetized rats, isolated rat atria, isolated guinea pig hearts, isolated guinea pig intestines and intact anesthetized cats. (uri.edu)
  • Smith, John Charles, "The Comparative Cardiovascular Effects of Substituted Cyclohexane Derivatives" (1963). (uri.edu)
  • Cyclohexane is a cycloalkane with the molecular formula C6H12. (wikipedia.org)
  • Therefore, to reduce torsional strain, cyclohexane adopts a three-dimensional structure known as the chair conformation, which rapidly interconvert at room temperature via a process known as a chair flip. (wikipedia.org)
  • The idea that the chair conformation is the most stable structure for cyclohexane was first proposed as early as 1890 by Hermann Sachse, but only gained widespread acceptance much later. (wikipedia.org)
  • This conformation allows for the most stable structure of cyclohexane. (wikipedia.org)
  • Another conformation of cyclohexane exists, known as boat conformation, but it interconverts to the slightly more stable chair formation. (wikipedia.org)
  • If cyclohexane is mono-substituted with a large substituent, then the substituent will most likely be found attached in an equatorial position, as this is the slightly more stable conformation. (wikipedia.org)
  • At 25 °C, 99.99% of all molecules in a cyclohexane solution adopt this conformation. (wikipedia.org)
  • Rapid cooling of a sample of cyclohexane from 1073 K to 40 K will freeze in a large concentration of twist-boat conformation, which will then slowly convert to the chair conformation upon heating. (wikipedia.org)
  • While the boat conformation is not necessary for interconversion between the two chair conformations of cyclohexane, it is often included in the reaction coordinate diagram used to describe this interconversion because its energy is considerably lower than that of the half-chair, so any molecule with enough energy to go from twist-boat to chair also has enough energy to go from twist-boat to boat. (wikipedia.org)
  • Thus, there are multiple pathways by which a molecule of cyclohexane in the twist-boat conformation can achieve the chair conformation again. (wikipedia.org)
  • Cyclohexane conformation happen to be extensively studied throughout organic chemistry because they're the classical illustration of conformational isomerism and have noticeable influence on the physical and element properties of cyclohexane. (assignmentpoint.com)
  • A cyclohexane conformation is any one several three-dimensional shapes which a cyclohexane molecule may assume while preserving the integrity of its chemical bonds. (assignmentpoint.com)
  • In methyl phosphate, the phosphorus is sp 3 hybridized and the O-P-O bond angle varies from 110° to 112 o . trigonal pyramidal Another important difference between benzene and cyclohexane is that the benzene is an unsaturated molecule while cyclohexane is a saturated molecule. (johnhicksms.com)
  • Using a series of isoreticular MOFs with void connections of varying diameters, the selective separation of benzene and cyclohexane in both liquid and vapor phases is shown. (rsc.org)
  • Many are puzzled by how the production of cyclohexane seems to have become stagnant. (ipl.org)
  • A high shear mechanical device incorporated into a process and system for the production of cyclohexane is capable of decreasing mass transfer limitations, thereby enhancing the cyclohexane production process. (patents.com)
  • Although rather unreactive, cyclohexane undergoes catalytic oxidation to produce cyclohexanone and cyclohexanol. (wikipedia.org)
  • In its current industrial production process, first KA oil (a mixture of cyclohexanol and cyclohexanone) is obtained from cyclohexane ineffective oxidation (ca. 4% cyclohexane conversion to assure a reasonable selectivity, ca. 85%), and then converted, at high pressure and 150 ºC and in the presence of copper and chromium oxides, to cyclohexanone which is then used to form caprolactam, the monomer for produce PA 6. (eurekalert.org)
  • Offering you a complete choice of products which include Cyclohexane Chemicals, Cyclohexanone Chemicals, Cyclohexene Chemicals, Heptanesulfonic Acid Sodium Salt Anhydrous, Diethylamine Chemicals and Di-isopropyl Ether. (indiamart.com)
  • Cyclohexane carboxylic acid accumulated to a concentration of 260 μM, accounting for about 18% of the initial benzoate added. (asm.org)
  • On an industrial scale, cyclohexane is produced by hydrogenation of benzene in the presence of a Raney nickel catalyst. (wikipedia.org)
  • Cyclohexane is a colorless and flammable liquid, which is produced by catalytic hydrogenation of benzene. (webnewswire.com)
  • 2, 3] Recently, organocatalytic cascade approaches to polysubstituted chiral cyclohexanes have attracted a great deal of attention, owing to the prevalence of such motifs in pharmaceutical compounds and complex natural products. (docme.ru)
  • it was compared to the previously reported hexadentate H 2 hox to determine the effect of a backbone reinforced from adding a chiral 1S,2S-trans-cyclohexane on metal complex stability, kinetic inertness, and in vivo pharmacokinetics. (nih.gov)
  • Cyclohexane is sometimes used as a non-polar organic solvent, although n-hexane is more widely used for this purpose. (wikipedia.org)
  • It is frequently used as a recrystallization solvent, as many organic compounds exhibit good solubility in hot cyclohexane and poor solubility at low temperatures. (wikipedia.org)
  • The catalytic activity of the modified zeolites in the reaction of selective oxidative dehydrogenation of cyclohexane to cyclohexadiene-1,3 has been investigated. (scirp.org)
  • Aliyev, A. , Shabanova, Z. , Najaf-Guliyev, U. and Melikova, I. (2015) Selection of Active Modified Zeolite Catalyst and Kinetics of the Reaction of Selective Oxidative Dehydrogenation of Cyclohexane to Cyclohexadiene 1,3. (scirp.org)
  • Yagodovskaya, T.V., Kifyak, R.A. and Belyaeva, K.S. (2009) Dehydrogenation of Cyclohexane on the Industrial Platinum AP-64 Catalyst Which Was Exposed to Plasmachemical Treatment. (scirp.org)
  • Koel, B.E., Blank, D.A. and Carter, E.A. (1998) Thermochemistry of the Selective Dehydrogenation of Cyclohexane to Benzene on Pt Surfaces. (scirp.org)
  • Biniwale, R.B., Kariya, N. and Ichikawa, M. (2005) Dehydrogenation of Cyclohexane over Ni Based Catalysts Supported on Activated Carbon Using Spray-Pulsed Reactor and Enhancement in Activity by Addition of a Small Amount of Pt. (scirp.org)
  • Oxidative dehydrogenation of cyclohexane and cyclohexene over supporte" by Nicholas F. Dummer, Salem Bawaked et al. (edu.au)
  • Oxidative dehydrogenation of cyclohexene over AuPd/TiO2 or Pd/TiO2 catalysts was found to be very effective (conversion >99% at 423 K). These results indicate that the first step in the reaction sequence of cyclohexane to cyclohexene is the slowest step. (edu.au)
  • In organic chemistry, cyclohexane conformations are any of several three-dimensional shapes adopted by molecules of cyclohexane. (wikipedia.org)
  • Therefore, the cyclohexane ring tends to assume certain non-planar (warped) conformations, which have all angles closer to 109.5° and therefore a lower strain energy than the flat hexagonal shape. (wikipedia.org)
  • In cyclohexane, the two chair conformations have the same energy. (wikipedia.org)
  • Students often complain they are terrible at drawing organic chemistry structures especially chair conformations of the cyclohexane rings. (wyzant.com)
  • Whenever I answer a problem involving energy conformations I will always start with a quick diagram of a cyclohexane ring with the axial positions drawn in. (wyzant.com)
  • Cyclohexane is a colorless, flammable liquid with a distinctive detergent-like odor, reminiscent of cleaning products (in which it is sometimes used). (wikipedia.org)
  • Cyclohexane is a highly flammable liquid. (ipl.org)
  • Cyclohexane is a cycloalkane with the molecular formula C 6 H 12.Cyclohexane is non-polar.Cyclohexane is a colourless, flammable liquid with a distinctive detergent-like odor, reminiscent of cleaning products (in which it is sometimes used).Cyclohexane is mainly used for the industrial production of adipic acid and caprolactam, which are precursors to nylon. (johnhicksms.com)
  • It is not a widely used method due to the close range of boiling points between byproducts dimethyl pentanes in natural cyclohexane concentrate. (ipl.org)
  • We measured interfacial tensions using the spinning drop technique in two-phase oil/water (O/W) systems containing sodium dodecyl sulfate (SDS), n-pentanol, NaCl, cyclohexane, and water. (uu.nl)
  • A new style packed column technology and a new process is used to reform the separating column system of cyclohexene.The concentration of cyclohexene is reduced to 4.0% from 6.5% at the top of cyclohexene separating column and the concentration of cyclohexane is reduced to 2.5% from 3.5%~4% at the top of cyclohexene recovery column,while the purity of cyclohexene is raised from 95% to 97% or above. (cnki.com.cn)
  • We have achieved a respectable position in the industry by offering a quality assured collection of Cyclohexane Chemicals to the clients. (indiamart.com)
  • The waste water stream from the cyclohexane oxidation process of Gujarat state fertilizers and chemicals ltd. has been vacuum distilled with a vacuum of 700 mmHg to remove water followed by filtration to separate the solid and liquid fractions. (niscair.res.in)
  • For 1,2- and 1,4-disubstituted cyclohexanes, a cis configuration leads to one axial and one equatorial group. (wikipedia.org)
  • Detailed data and modeling of cyclohexane flames establish that a mixture of pathways contributes to benzene formation and that this mixture changes with stoichiometry. (unl.edu)
  • In this process, we find that ultraviolet (UV) irradiation (λ = 365 nm) of a cyclohexane/HNO3 mixture in a N2 atmosphere efficiently produces nitrocyclohexane and adipic acid with total selectivity (ca. 87 %) at a 22 % conversion rate. (deepdyve.com)
  • With the increasing restraints on available compounds, there has been a shift to using brominated flame retardants that has seen the production of alternative brominated flame retardants such as 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH), which has been detected in the environment. (diva-portal.org)
  • trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors. (fishersci.com)
  • 1,4-bis-(hydroxymethyl)-cyclohexane manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • Furthermore, 1,4-bis-(hydroxymethyl)-cyclohexane prices in regional markets can be found in the report with regards to countries and companies. (marketpublishers.com)
  • The report also focuses on 1,4-bis-(hydroxymethyl)-cyclohexane consumers by providing data on companies that use it. (marketpublishers.com)
  • 1,4-Bis-(hydroxymethyl)-cyclohexane (CAS 105-08-8) Market Research Report 2018 contents were prepared and placed on the website in March, 2018. (marketpublishers.com)
  • Please note that 1,4-Bis-(hydroxymethyl)-cyclohexane (CAS 105-08-8) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • The Gibbs free energy, enthalpy and entropy of partitioning of 45 simple aromatic compounds (phenols, benzoic acids and acetanilides) from water to octanol and from water to cyclohexane have been determined using the filter-probe method. (mdpi.com)
  • The selective hydrogenation of aromatic compounds to cyclohexanes was found to be promoted by chitin-supported ruthenium nanoparticles (Ru/chitin) under near-neutral, aqueous conditions without the loss of C-O/C-N linkages at benzylic positions. (rsc.org)
  • We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. (nih.gov)
  • Asymmetric Organocatalytic Relay Cascades Catalyst-Controlled Stereoisomer Selection in the Synthesis of Functionalized Cyclohexanes. (docme.ru)
  • Zuschriften DOI: 10.1002/ange.200905014 Asymmetric Catalysis Asymmetric Organocatalytic Relay Cascades: Catalyst-Controlled Stereoisomer Selection in the Synthesis of Functionalized Cyclohexanes** Yao Wang, Rong-Gang Han, Yong-Long Zhao, Shu Yang, Peng-Fei Xu,* and Darren J. Dixon* Amongst the challenges currently facing synthetic chemists is the development of efficient and elegant chemical processes that allow the rapid creation of stereochemically defined molecular complexity and diversity. (docme.ru)
  • Cyclohexane is mainly used for the industrial production of adipic acid and caprolactam, which are precursors to nylon. (wikipedia.org)
  • Cyclohexane Market Size is mainly used in the production of adipic acid and caprolactam. (webnewswire.com)
  • 1. The fractions in the fractional distillation such as N-hexane, isohexane, methyl cyclopentane have normal boiling point close to cyclohexane which makes the recovery of cyclohexane uneconomic and difficult. (ipl.org)
  • Reine P, Ortuño AM, Mariz IFA, Ribagorda M, Cuerva JM, Campaña AG, Maçôas E and Miguel D (2020) Simple Perylene Diimide Cyclohexane Derivative With Combined CPL and TPA Properties. (ugr.es)
  • Cyclohexane is also used for calibration of differential scanning calorimetry (DSC) instruments, because of a convenient crystal-crystal transition at −87.1 °C. Cyclohexane vapor is used in vacuum carburizing furnaces, in heat treating equipment manufacture. (wikipedia.org)
  • The US cyclohexane market came down in Q4, following direction from the feedstock benzene market. (icis.com)
  • 1.1 This test method covers the determination of specific impurities in, and the purity of benzene for cyclohexane feedstock by gas chromatography. (bsigroup.com)
  • Cyclohexane has two crystalline phases. (wikipedia.org)
  • Intramolecular Conformational Isomerism of the Cyclohexane Rings in Crystalline 2 3-Di-(cis-4-chloro-1-methylcyclohexyl)-trans-2-butene. (docme.ru)
  • Sigma-Aldrich offers a number of Cyclohexane products. (geologus.eu)
  • On the other hand, when enough aniline is used (see snapshots 3 and 4), the azeotrope disappears and there is an inversion of volatility, so that the heavy-boiling cyclohexane distills overhead in an extractive distillation process [2, 3]. (wolfram.com)
  • In this paper, we report the results of gas chromatography-mass spectrometry (GC-MS) and 13 C nuclear magnetic resonance spectroscopy ( 13 C-NMR) to elucidate the pathway for crotonate oxidation and cyclohexane carboxylate formation in S. aciditrophicus . (asm.org)
  • The anaerobic, syntrophic bacterium Syntrophus aciditrophicus grown in pure culture produced 1.4 ± 0.24 mol of acetate and 0.16 ± 0.02 mol of cyclohexane carboxylate per mole of crotonate metabolized. (asm.org)
  • Sample is a synthetic blend prepared with impurities known to be present in cyclohexane at concentrations expected to be found in commercial samples. (restek.com)
  • Benzene, hydrogen and recycled cyclohexane with platinum catalyst contains low sulfur poisoning while nickel catalyst are permanently poisoned by sulfur. (ipl.org)
  • The space-time yield of benzene from cyclohexane at 473 K was determined to be 53.7 mol/kgcat/h rising to 87.3 mol/kgcat/h at 673 K for the Pd catalyst. (edu.au)
  • Cyclohexane-based low molecular weight hydrogelators: A chirality investigation Friggeri, A., van der Pol, C., Heeres, A., ... which is in contrast to the logarithmic curves generally observed for gels derived from low molecular weight gelators (LMWGs). (geologus.eu)
  • 15]. The molecular weight of cyclohexane is 84.162 g/mol. (geologus.eu)
  • Calculate the molecular weight of an unknown substance if 0.2064 grams of solid was added to 25.00 mL of cyclohexane and the resultant solution exhibited a freezing point depression of 2.1 degrees C 4. (geologus.eu)
  • If the original solution was made with 2.462 g of naphthalene dissolved in 29.78 g of cyclohexane, the molecular weight of naphthalene can be calculated using equation 8. (geologus.eu)
  • The hydrolysis of Methyl cyclohexane (Molecular weight =98.19) is conducted in a series of reactors. (geologus.eu)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of Cyclohexane Oxide. (reportsnreports.com)
  • The data are consistent with a pathway for cyclohexane carboxylate formation involving the condensation of two-carbon units derived from crotonate degradation with CO 2 addition, rather than the use of the intact four-carbon skeleton of crotonate. (asm.org)
  • This chapter provides the diffusion coefficient of benzene in cyclohexane at different concentrations measured using Taylor dispersion technique, Rayleigh interferometry, open ended capillary, NMR spin echo pulse gradient, NMR spin echo field gradient, Gouy interferometry, forced Rayleigh scattering, diaphragm cell and closed capillary. (springer.com)
  • This chapter provides the diffusion coefficient of methyl-cyclohexane in heptan-1-ol at different concentrations measured using diaphragm cell. (springer.com)
  • This chapter provides the diffusion coefficient of hexafluoro-benzene in cyclohexane at different concentrations measured using NMR spin echo pulse gradient and diaphragm cell. (springer.com)
  • as a result cyclohexane has been deemed a 0 in total ring strain. (wikipedia.org)
  • The increasing use of nylon-based thermoplastics in manufacturing various automotive parts is likely to boost demand for Cyclohexane during the forecast period. (webnewswire.com)
  • Moreover, the growing petrochemical sector in this region is anticipated to fuel the demand for Cyclohexane during the forecast period. (webnewswire.com)
  • Considering these trends, the Global Cyclohexane Market is set to witness a considerable competition during the forecast period, 2018-2023. (webnewswire.com)
  • The company produces caprolactam using cyclohexane, hence creating a market demand for caprolactam. (webnewswire.com)
  • Winkelmann J. (2018) Diffusion coefficient of benzene in cyclohexane. (springer.com)
  • Winkelmann J. (2018) Diffusion coefficient of methyl-cyclohexane in heptan-1-ol. (springer.com)
  • This chapter provides the diffusion coefficient of 1,4,7,10,13,16-hexaoxa-cyclooctadecane in cyclohexane at infinite dilution for various temperature and pressure conditions measured using Taylor dispersion technique. (springer.com)