The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Relating to the size of solids.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Finely divided solid matter with particle sizes smaller than a micrometeorite, thus with diameters much smaller than a millimeter, moving in interplanetary space. (NASA Thesaurus, 1994)
Any solid objects moving in interplanetary space that are smaller than a planet or asteroid but larger than a molecule. Meteorites are any meteoroid that has fallen to a planetary surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Drugs used to treat or prevent parasitic infections.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Substances that are destructive to protozoans.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Antifibrinolytic hemostatic used in severe hemorrhage.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.
Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
Loss of blood during a surgical procedure.
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Analysis of gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring. (1/683)

A simple method for the determination of gabapentin (Neurontin) is described. The method uses solid-phase extraction by disk column and derivatization followed by gas chromatographic-mass spectrometric analysis. The single-step derivatization with MTBSTFA produces a t-BDMS derivative of both the carboxylic and amine moieties of the molecule. Each step of the procedure was optimized to assure reliable performance of the method. The assay limit of detection was 0.1 microg/mL with a linear range from 1.0 to 35 microg/mL. Within-run (n = 3) and between-run (n = 40) coefficients of variation were less than 8.2 and 15.9%, respectively. The method has proven reliable in routine production for more than a year, producing clean chromatography with unique ion fragments, consistent ion mass ratios, and no interferences. Statistical analysis of the gabapentin concentrations measured in 1020 random specimens over a 2-month period showed a mean concentration of 6.07 microg/mL with a standard deviation of 5.28.  (+info)

Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. (2/683)

Repetitive ectopic discharges from injured afferent nerves play an important role in initiation and maintenance of neuropathic pain. Gabapentin is effective for treatment of neuropathic pain but the sites and mechanisms of its antinociceptive actions remain uncertain. In the present study, we tested a hypothesis that therapeutic doses of gabapentin suppress ectopic afferent discharge activity generated from injured peripheral nerves. Mechanical allodynia, induced by partial ligation of the sciatic nerve in rats, was determined by application of von Frey filaments to the hindpaw. Single-unit afferent nerve activity was recorded proximal to the ligated sciatic nerve site. Intravenous gabapentin, in a range of 30 to 90 mg/kg, significantly attenuated allodynia in nerve-injured rats. Furthermore, gabapentin, in the same therapeutic dose range, dose-dependently inhibited the ectopic discharge activity of 15 injured sciatic afferent nerve fibers through an action on impulse generation. However, the conduction velocity and responses of 12 normal afferent fibers to mechanical stimulation were not affected by gabapentin. Therefore, this study provides electrophysiological evidence that gabapentin is capable of suppressing the ectopic discharge activity from injured peripheral nerves. This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain.  (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (3/683)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer.  (+info)

An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. (4/683)

We performed intracellular recordings from a rat corticostriatal slice preparation in order to compare the electrophysiological effects of the classical antiepileptic drug (AED) phenytoin (PHT) and the new AEDs lamotrigine (LTG) and gabapentin (GBP) on striatal neurons. PHT, LTG and GBP affected neither the resting membrane potential nor the input resistance/membrane conductance of the recorded cells. In contrast, these agents depressed in a dose-dependent and reversible manner the current-evoked repetitive firing discharge. These AEDs also reduced the amplitude of glutamatergic excitatory postsynaptic potentials (EPSPs) evoked by cortical stimulation. However, substantial pharmacological differences between these drugs were found. PHT was the most effective and potent agent in reducing sustained repetitive firing of action potentials, whereas LTG and GBP preferentially inhibited corticostriatal excitatory transmission. Concentrations of LTG and GBP effective in reducing EPSPs, in fact, produced only a slight inhibition of the firing activity of these cells. LTG, but not PHT and GBP, depressed cortically-evoked EPSPs increasing paired-pulse facilitation (PPF) of synaptic transmission, suggesting that a presynaptic site of action was implicated in the effect of this drug. Accordingly, PHT and GBP, but not LTG reduced the membrane depolarizations induced by exogenously-applied glutamate, suggesting that these drugs preferentially reduce postsynaptic sensitivity to glutamate released from corticostriatal terminals. These data indicate that in the striatum PHT, LTG and GBP decrease neuronal excitability by modulating multiple sites of action. The preferential modulation of excitatory synaptic transmission may represent the cellular substrate for the therapeutic effects of new AEDs whose use may be potentially extended to the therapy of neurodegenerative diseases involving the basal ganglia.  (+info)

Adenosylcobalamin-mediated methyl transfer by toluate cis-dihydrodiol dehydrogenase of the TOL plasmid pWW0. (5/683)

We identified and characterized a methyl transfer activity of the toluate cis-dihydrodiol (4-methyl-3,5-cyclohexadiene-cis-1, 2-diol-1-carboxylic acid) dehydrogenase of the TOL plasmid pWW0 towards toluene cis-dihydrodiol (3-methyl-4,5-cyclohexadiene-cis-1, 2-diol). When the purified enzyme from the recombinant Escherichia coli containing the xylL gene was incubated with toluene cis-dihydrodiol in the presence of NAD+, the end products differed depending on the presence of adenosylcobalamin (coenzyme B12). The enzyme yielded catechol in the presence of adenosylcobalamin, while it gave 3-methylcatechol in the absence of the cofactor. Adenosylcobalamin was transformed to methylcobalamin as a result of the enzyme reaction, which indicates that the methyl group of the substrate was transferred to adenosylcobalamin. Other derivatives of the cobalamin such as aquo (hydroxy)- and cyanocobalamin did not mediate the methyl transfer reaction. The dehydrogenation and methyl transfer reactions were assumed to occur concomitantly, and the methyl transfer reaction seemed to depend on the dehydrogenation. To our knowledge, the enzyme is the first dehydrogenase that shows a methyl transfer activity as well.  (+info)

The management of epilepsy in a hospital for people with a learning disability. (6/683)

The study examined changes in the use of antiepileptic drugs (AEDs) in a large hospital for people with a learning disability over a 2 year period, the use of investigations, and the presence of medication side-effects. The surveys were carried out in 1993 and 1995/6. In 1993, 27% of patients were being treated for epilepsy and in 1995/6, 30.1%. Ninety percent and 82.4% of patients, respectively, were receiving one or two AEDs. In the second survey there were fewer prescriptions for phenobarbitone (5.8% vs. 12.5%) and an increase in the use of lamotrigine (21.6% vs. 5%), gabapentin (5.8% vs. 0) and vigabatrin (3.9% vs. 2.5% in 1993). Side-effects were recorded in 6 (11.8%) patients. Seven (21.2%) patients receiving carbamazepine were found to have hyponatraemia. Of the 54 electroencephalograms (EEGs) requested, 41 (76%) were reported as abnormal. Six CT brain scans had been conducted, of which five were abnormal. People receiving antipsychotic drugs had fewer seizures than average.  (+info)

Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases. (7/683)

We report three consecutive patients with hypersensitivity syndrome (HSS) due to phenytoin and carbamazepine and successful treatment with gabapentin. HSS is a rare but potentially fatal reaction to multiple drugs including several anticonvulsants. Cross-reactivity among drugs may occur. Immediate withdrawal of the offending drug is the most important step in treatment. Benzodiazepines acutely and, after resolution of the hepatitis, valproic acid have been successfully used for seizure control in patients with HSS. Our cases indicate that gabapentin is also a safe anticonvulsant in HSS.  (+info)

Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats. (8/683)

In this study, we investigated the effectiveness of gabapentin (Neurontin), administered spinally with a microdialysis fiber, in reducing nociceptive behavioral responses induced by a knee joint inflammation model. This model is produced by injection of the knee joint with kaolin and carrageenan in rats. The resultant knee joint inflammation produces a secondary hyperalgesia to radiant heat applied to the hindpaw. Both pretreatment and post-treatment protocols were examined. Spinal administration of gabapentin (10 mg/ml) infused 1.5 h before induction of knee joint inflammation, although having no effect on the baseline, prevented the development of heat hyperalgesia. Gabapentin also prevented the development of other pain-related behaviors scored subjectively. Gabapentin had no effect, however, on the joint circumference increase typical in this model. In animals with fully developed knee joint inflammation, gabapentin produced a reversal of heat hyperalgesia. The paw withdrawal latency responses and subjective pain scores were no longer significantly different from baseline, but joint circumference increases remained. These data suggest that gabapentin is an effective antinociceptive agent when administered either before or after induction of knee joint inflammation acting through a central neurogenic mechanism.  (+info)

Cyclohexanecarboxylic acid [4-(5-methyl-isoxazol-3-ylsulfamoyl)-phenyl]-amide | C17H21N3O4S | CID 1181036 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Cyclohexanecarboxylic acid, 2-amino-3-ethyl- | C9H17NO2 | CID 20196303 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylic acid |p|SPC Code: SPC-a215|/p||p|CAS RN: 115951-16-1|/p||p|Smiles: O=C(OC(C)(C)C)NC1(C(=O)O)(CCCCC1)|/p||p|Formula: C12H21NO4|/p||p|MolWeight: 243.302|/p||p|Purity: 95|/p|
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
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Third generation aromatase inhibitors (AIs) are more effective than tamoxifen in the treatment of estrogen receptor (ER) positive breast cancer. However, long-term use of AIs commonly results in resistance. We examined whether compound JCC76{Cyclohexanecarboxylic acid [3-(2,5-dimethyl-benzyloxy)-4-(methanesulfonyl-methyl-amino)-phenyl]-amide}, an analog of Cyclooxygenase-2 (COX-2) inhibitor nimesulide, can inhibit the growth of AI-insensitive breast cancer cells and the mechanisms by which the compound affects cell proliferation. LTEDaro (long term estrogen deprived MCF-7aro cell) cells, which are a model for AI resistance, were used in this study. JCC76 effectively inhibited LTEDaro cell proliferation with an IC(50) of 2.75 ± 0.31 μM. Further investigations reveal that the compound significantly induced apoptosis in LTEDaro cells by decreasing pAKT, BCL-2 and pBad protein levels, which were all up regulated in the cells after long term estrogen deprivation. LTEDaro tumor size and weight were
A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-yl))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, provided that when A is N, B is O, or when A is O, B is N: Formula (III) and Formula (II).
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TY - JOUR. T1 - Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid. AU - Chen, Ching Wen. AU - Chao, Yee. AU - Chang, Ying Hsin. AU - Hsu, Ming Jen. AU - Lin, Wan Wan. PY - 2002/12. Y1 - 2002/12. N2 - 1. Inducible nitric oxide (iNOS) is thought to involve in host defence and tissue damage in inflammatory loci. In previous study, we have found that the endonuclease inhibitor aurintricarboxylic acid (ATA) can protect macrophages from cell death induced by bacterial lipopolysaccharide. This action is through the interruption with signalling pathways for NF-κB and AP-1 activation, and thus iNOS expression. In this study we have addressed the effects of ATA on JAK-STAT signalling pathways. 2. In murine RAW 264.7 macrophages, IFN-γ-mediated NO production and iNOS expression were concentration-dependently reduced by the presence of 3-100 μM ATA. 3. IFN-γ-induced STAT1 activation, as assessed from its tyrosine phosphorylation, nuclear ...
Aurintricarboxylic acid; Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.
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Inclusion of aurintricarboxylic acid (ATA) in extraction buffers for the isolation of RNA from animal tissues resulted in high yields (0.5-2.0 mg/g of tissue) of undegraded material as judged by agarose-gel-electrophoretic analyses and Northern-blotting experiments. However, ATA bound to nucleic acids, forming stable complexes, and so we have established methods for spectrophotometric quantification of RNA in these coloured complexes, and for easy removal of sufficient ATA to leave RNA in a consistently hybridizable condition at the end of a purification. The use and subsequent removal of ATA was straightforward and gave satisfactory results for all rat tissues tested.. ...
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TY - JOUR. T1 - Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy. AU - Baxter, Katherine J.. AU - Hafling, Jennifer. AU - Sterner, Jennifer. AU - Patel, Adarsh U.. AU - Giannopoulos, Helen. AU - Heiss, Kurt F.. AU - Raval, Mehul V. N1 - Funding Information: Institutional Review Board approval was obtained prior to chart review and all protected health information was kept strictly confidential. Informed consent was waived given the retrospective nature of the study.. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Purpose: Though gabapentin is increasingly used as a perioperative analgesic, data regarding effectiveness in children are limited. The purpose of this study was to evaluate gabapentin as a postoperative analgesic in children undergoing appendectomy. Methods: A 12-month retrospective review of children undergoing appendectomy was performed at a two-hospital childrens institution. Patients receiving gabapentin (GP) were matched (1:2) with patients who did ...
Title: Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences. VOLUME: 10 ISSUE: 8. Author(s):M. Dauri, S. Faria, A. Gatti, L. Celidonio, R. Carpenedo and A. F. Sabato. Affiliation:Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital of Tor Vergata, Via Di S. Eufemia, 11, 00187 Rome, Italy.. Abstract: Background: Gabapentin and pregabalin inhibit Ca2+ currents via high-voltage-activated channels containing the α2δ-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of clinical trials indicate that gabapentin and pregabalin could be effective as postoperative analgesics. This systematic-narrative review aims to analyse the most recent evidences regarding the effect of gabapentinoids on postoperative pain treatment. Methods: Medline, The ...
Gabapentin and pregabalin prescribing have increased substantially over the recent years. Some evidence supports that gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. On the other hand, other studies have shown that those drugs are to be beneficial in the treatment of non-neuropathic pain and improves the analgesic efficacy of opioids both at rest and in movement, reduces analgesic consumption and opioid-related adverse effects. Therefore, it is essential to evaluate the rate of their prescriptions as well as monitoring and checking any severe side effects. The study is aimed at identifying the rate and the indications of gabapentin and pregabalin prescriptions at King Abdul-Aziz (Alzaher) Hospital-Makkah. A cross-sectional study was conducted from medical records of in-patients and outpatients clinics from January, 2018 through January, 2019. Data analysis was performed using SPSS and Prism 5.0
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Kinney MA, Mantilla CB, Carns PE, Passe MA, Brown MJ, Hooten WM, Curry TB, Long TR, Wass CT, Wilson PR, Weingarten TN, Huntoon MA, Rho RH, Mauck WD, Pulido JN, Allen MS, Cassivi SD, Deschamps C, Nichols FC, Shen KR, Wigle DA, Hoehn SL, Alexander SL, Hanson AC, Schroeder DR. Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study. Pain Pract. 2012 Mar; 12: (3)175-83 ...
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US and European studies have been completed testing Myotrophin (IGF-1, Insulin-like Growth Factor -1) in ALS. As the name implies, IGF-1 is a growth factor which is hoped will prolong survival of motor neurons in ALS. The results are conflicting and therefore have not been convincing enough to earn FDA approval. The FDA did approve the drug for further investigational use. More recently, however (May 8, 1997), the FDA, in a 6-3 vote, decided against approval for Myotrophin. Although clinical trials with Myotrophin are still ongoing, the future of this drug in ALS treatment seems bleak.. In a small clinical trial, Neurontin (gabapentin) showed a trend towards improvement in ALS patients, but did not reach statistical significance, and therefore was deemed a negative study. A larger trial of Neurontin in ALS proved negative. Therefore, although Neurontin is also a glutamate inhibitor, it did not prove effective in the treatment of ALS.. A clinical trial of Topamax (topiramate) in the treatment of ...
Material primarily related to a lawsuit filed by a former Parke-Davis employee who alleged that the company violated federal regulations by engaging in systematic efforts to promote the drug gabapentin (Neurontin) for uses not approved by the U.S. Food and Drug Administration. Includes marketing reports and internal documents and legal documents pertaining to the case (settled in May 2004). From the Kalmanovitz Library and Center for Knowledge Management, University of California, San Francisco ...
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The molecular formula C7H12O2 may refer to: Butyl acrylate Cyclohexanecarboxylic acid trans-3-Methyl-2-hexenoic acid (TMHA) ...
... the diethyl ester of mesoxalic acid Shikimic acid, a cyclohexene, cyclitol, and cyclohexanecarboxylic acid This set index page ...
In industry, the nitrosodecarboxylation reaction between nitrosylsulfuric acid and cyclohexanecarboxylic acid is used to ... The compound is the mixed anhydride of sulfuric acid and nitrous acid. In organic chemistry, it is used as a reagent for ... Nitrosylsulfuric acid is the chemical compound with the formula NOHSO4. It is a colourless solid that is used industrially in ... George A. Olah, G. K. Surya Prakash, Qi Wang, Xing-Ya Li (2001). Nitrosylsulfuric Acid. E-EROS Encyclopedia of Reagents for ...
... is a simple alkyl-substituted cyclohexanecarboxylic acid. The salts and esters of buciclic acid are known as buciclates ( ... Buciclic acid, or bucyclic acid, systematic name trans-4-butylcyclohexane-1-carboxylic acid, ... bucyclates). Pharmaceutical examples of esters of this acid include testosterone buciclate, a long-acting prodrug of the ... Ciclotic acid http://apps.who.int/medicinedocs/documents/s20132en/s20132en.pdf Shalender Bhasin (13 February 1996). ...
... is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. It is a colorless solid that can be extracted ... Dehydrogenation and oxidation of quinic acid affords gallic acid. Quinic acid is used as an astringent. This acid is a ... On the reduction of quinic acid to benzoic acid and its transformation into hippuric acid in the animal organism), Annalen der ... It is made synthetically by hydrolysis of chlorogenic acid. Quinic acid is also implicated in the perceived acidity of coffee. ...
The thermal decomposition of nickel benzoate and of the nickel salt of cyclohexanecarboxylic acid". Journal of the Chemical ... The nickel organic acid salts are organic acid salts of nickel. In many of these the ionised organic acid acts as a ligand. ... Cyclopropane carboxylic acid forms two basic salts with nickel, a hydrate Ni 9(OH) 2(H 2O) 6(C 4H 5O 2) 8 • 2H 2O with density ... Boiling acetic acid converts the nickel to nickel acetate. The terephthalate converts to a basic salt when boiled in water. ...
... acid dicyclomine quinic acid shikimic acid tranexamic acid Quinic acid Shikimic acid Chorismic acid Cyclohexanecarboxylic+Acids ... Derivatives related to cyclohexanecarboxylic acid include: abscisic acid buciclic acid chlorogenic acid chorismic ... Cyclohexanecarboxylic acid exhibits the reactions typical of carboxylic acids, including its conversion to the acid chloride ... Cyclohexanecarboxylic acid is the organic compound with the formula C6H11CO2H. It is the carboxylic acid of cyclohexane. It is ...
Cyclohexanecarboxylic acids. *World Health Organization essential medicines. Hidden categories: *CS1 maint: Multiple names: ... Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to ... Tranexamic acid is frequently used following major trauma.[10] Tranexamic acid is used to prevent and treat blood loss in a ... Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.[citation ...
... , more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid ... Mycosporine-like amino acids[edit]. Mycosporine-like amino acids are small secondary metabolites produced by organisms that ... Gallic acid biosynthesis. Gallic acid is formed from 3-dehydroshikimate by the action of the enzyme shikimate dehydrogenase to ... Shikimic acid is a precursor for: *indole, indole derivatives and aromatic amino acid tryptophan and tryptophan derivatives ...
1. N. G. Gaylord, "Reduction with Complex Metal Hydrides." Interscience, New York, 1956; W. G. Brown, Org. React. 6, 469 (1951). 2. A. I. Vogel, "Practical Organic Chemistry," 3rd ed. Longmans, London, (1956). 3. W. G. Dauben, R. C. Tweit, an R. L. MacLean, /. Amer. Chem. Soc. 77, 48 (1955). 4. A. C. Cope an E. Ciganek, Org. Syn. Collective Vol. 4, 339 (1963). 5. E. L. EHeI, Rec. Chem. Progr. 22, 129 (1961). 6. E. L. Eliel, R. J. L. Martin, an D. Nasipuri, Org. Syn. 47, 16 (1967). 7. R. A. Daignault an E. L. Eliel, Org. Syn. 47, 37 (1967). 8. Y. M. Y. Haddad, H. B. Henbest, J. Husbands, an T. R. B. Mitchell, Proc. Chem. Soc. London, p. 361 (1964). 9. E. L. Eliel, T. W. Doyle, R. O. Hutchins, an E. C. Gilbert, cited in M. Fieser and L. Fieser,"Reagents for Organic Synthesis," Vol. 2, p. 228. Wiley/Interscience, New York, 1969. 10. A. Zurqiyah an C. E. Castro, Org. Syn. 49, 98 (1969) 11. A.Abiko an M.Masasune Tetrahedron Letters, 33, 38, p. 5517. (1992) 12. L. Gade, Lecture Course: Advanced ...
... cyclohexanecarboxylic acids MeSH D02.455.426.392.368.367.318 - cyclohexanols MeSH D02.455.426.392.368.367.340 - cyclohexanones ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...
... acid dicyclomine quinic acid shikimic acid tranexamic acid Quinic acid Shikimic acid Chorismic acid Cyclohexanecarboxylic+Acids ... Derivatives related to cyclohexanecarboxylic acid include: abscisic acid buciclic acid chlorogenic acid chorismic ... Cyclohexanecarboxylic acid exhibits the reactions typical of carboxylic acids, including its conversion to the acid chloride ... Cyclohexanecarboxylic acid is the organic compound with the formula C6H11CO2H. It is the carboxylic acid of cyclohexane. It is ...
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... cyclohexanecarboxylic acid ,=98.0% (TLC); CAS Number: 63216-49-9; Synonyms: Boc-1,2-cis-ACHC-OH; find related products, papers ... Alicyclic Amino Acids, Chemical Biology, Chemical Synthesis, Peptide Synthesis and Peptide Chemistry, Unnatural Amino Acids & ...
Cyclohexanecarboxylic acid, 2-amino-3-ethyl- , C9H17NO2 , CID 20196303 - structure, chemical names, physical and chemical ...
1S,2S)-rel-4-amino-2-methyl-cyclohexanecarboxylic acid; CAS Number: ; Linear Formula: C8H15NO2; find AChemBlock-ADVH49B82D7F ... www.achemblock.com/1s-2s-rel-4-amino-2-methyl-cyclohexanecarboxylic-acid.html. ...
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Find manufacturers and suppliers for cis-2-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride, 1127-99-7. Synonyms: (1R ... Suppliers of cis-2-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride. Supplier:. BioBlocks. ...
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant ...
... cyclohexanecarboxylic acid, 441015-89-0, (1R,2S,4S)-4-hydroxy-2-(4-methylbenzoyl)cyclohexane-1-carboxylic acid Molecular ... EMAIL INQUIRY to 7 (1R*,2R*,4S*)-4-hydroxy-2-(4-methyl-benzoyl)-cyclohexanecarboxylic acid (CAS No. 441015-88-9) suppliers ... 1R*,2R*,4S*)-4-hydroxy-2-(4-methyl-benzoyl)-cyclohexanecarboxylic acid (CAS No. 441015-88-9) Suppliers. Limit companies to: ... IUPAC Name: 4-hydroxy-2-(4-methylbenzoyl)cyclohexane-1-carboxylic acid , CAS Registry Number: 441015-88-9. Synonyms: AGN-PC- ...
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Cyclohexanecarboxylic Acid synonyms. cyclohexanoic acid; cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid; Benzoic acid, ... Cyclohexanecarboxylic Acid. Cyclohexanecarboxylic Acid bmse000546 - Data bmse000603 - Data ... CYCLOHEXANECARBOXYLIC ACID; Carboxycyclohexane; Hexahydrobenzoic acid; Cyclohexylmethanoic acid ... cyclohexanecarboxylic acid. PubChem Substance (SID): 111677746 4367041 12010. PubChem Compound (CID): 7413. KEGG: Compound ID ...
... cyclohexanecarboxylic acid), including NMR, HPLC, LC-MS, UPLC & more. ... cyclohexanecarboxylic acid) information and documentation regarding ((1S,2S)-2-(tert-Butoxycarbonyl) ... Amino acids. Amino acid. Amino acid derivatives. Analycial Science. DNA/RNA. Nucleosides & Nucleotides. Enzyme. Enzymes. Others ... Carboxylic Acid Salts. Carboxylic Acids. Chlorides. Diazoes. Difluoromethyls. Esters. More >>. Organometallic Reagents. ...
The Microbial Degradation of Cyclohexane Carboxylic Acid * D. I. Smith and A. G. Callely ... The Microbial Degradation of Cyclohexane Carboxylic Acid, Page 1 of 1 , Previous page , Next page , /docserver/preview/fulltext ...
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Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. It is a colorless solid that can be extracted ... Dehydrogenation and oxidation of quinic acid affords gallic acid. Quinic acid is used as an astringent. This acid is a ... On the reduction of quinic acid to benzoic acid and its transformation into hippuric acid in the animal organism), Annalen der ... It is made synthetically by hydrolysis of chlorogenic acid. Quinic acid is also implicated in the perceived acidity of coffee. ...
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... cyclohexanecarboxylic acid ,p,SPC Code: SPC-a215,/p,,p,CAS RN: 115951-16-1,/p,,p,Smiles: O=C(OC(C)(C)C)NC1(C(=O)O)(CCCCC1),/p,, ...
Cyclohexanecarboxylic acid [2-(5-methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-amide msds,Cyclohexanecarboxylic acid [2-(5-methoxy-2- ... Cyclohexanecarboxylic acid [2-(5-methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-amide density, Cyclohexanecarboxylic acid [2-(5-methoxy ... phenyl-1H-indol-3-yl)-ethyl]-amide properties, Cyclohexanecarboxylic acid [2-(5-methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-amidecas ... Find here Cyclohexanecarboxylic acid [2-(5-methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-amide molecular formula, ...
Cyclohexanecarboxylic acid, 3,4,5-tris(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1-hydroxy-, (1alpha,3R,4alpha,5R ... Cyclohexanecarboxylic acid, 3,4,5-tris(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1-hydroxy-, (1alpha,3R,4alpha,5R)- ... Substance Name: Cyclohexanecarboxylic acid, 3,4,5-tris(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1-hydroxy-, (1alpha, ...
... cyclohexanecarboxylic acid (194471-85-7). Find catalogue prices, chemical data, technical specifications and MSDS documents. ... cyclohexanecarboxylic acid Synonyms: Fmoc-1,2-cis-ACHC-OH; Fmoc-cis-2-aminocyclohexane carboxylic acid ...
Get 3-({[(2-chloroethyl)(nitroso)amino]carbonyl}amino)cyclohexanecarboxylic acid molecular formula, CAS number, boiling point, ...
Prediction : cyclohexanecarboxylic-acid-3a6-dimethyl-3-145-trimethylhex-2-enyl-123457891011b-decahydrocyclopentaanthracen-9-yl- ...
1-Hydroxy Cyclohexane Carboxylic Acid 1-Hydroxy Cyclohexane Carboxylic Acid View options ... Thioglycolic Acid Sodium (9) Thioglycolic acid protects tryptophan in amino acid analysis,and also mediates formation of ATP ... An inhibitor of fatty acid oxidation. An agent that prevents the metabolism of fatty acids and stimulates feeding. The sodium ... α-Ketoglutaric Acid Disodium Salt Dihydrate α-Ketoglutaric Acid Disodium Salt Dihydrate ...
The invention also provides a process for producing the novel avermectin and milbemycin derivatives by adding a carboxylic acid ... The medium and conditions of Example 1 were followed except that cyclohexane carboxylic acid sodium salt was used as the ... and 2-chloro-thiophene-4-carboxylic acid.. EXAMPLE 18. Repetition of the procedure of Example 17 but using the carboxylic acids ... glyoxylic acids of the formula R2 COCO2 H, methylamine derivatives of the formula R2 CH2 NH2, substituted lower alkanoic acids ...
Cyclohexanecarboxylic acids. *World Health Organization essential medicines. Hidden categories: *CS1 maint: Multiple names: ... Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to ... Tranexamic acid is frequently used following major trauma.[10] Tranexamic acid is used to prevent and treat blood loss in a ... Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.[citation ...
  • Tranexamic acid (TXA) is chemically designed as trans -4-(aminomethyl) cyclohexanecarboxylic acid, with chemical formula C 8 H 14 NO 2 . (hindawi.com)
  • The kringle 2 (K2) module of human plasminogen (Pgn) binds L-lysine and analogous zwitterionic compounds, such as the antifibronolytic agent trans-(aminomethyl)cyclohexanecarboxylic acid (AMCHA). (rcsb.org)
  • Meo-suc-AAPV-PNA, plasmin, trypsin and trans-4-(aminomethyl) cyclohexanecarboxylic acid were purchased from Sigma. (alliedacademies.org)
  • It is the carboxylic acid of cyclohexane. (wikipedia.org)
  • The invention also provides a process for producing the novel avermectin and milbemycin derivatives by adding a carboxylic acid or derivative thereof to a fermentation of an avermectin or milbemycin producing organism. (google.com)
  • Inhibition of neuronal cytosolic branched chain amino acid transamination by gabapentin or branched chain amino acid transport by the L-system substrate analog, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylic acid, lowered total de novo synthesis of glutamate by 30%, suggesting that branched chain amino acids may account for half of the glutamate nitrogen contributed by transamination reactions. (biomedsearch.com)
  • Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. (nih.gov)
  • an acid chloride from a carboxylic acid. (libretexts.org)
  • an alcohol from carboxylic acid. (libretexts.org)
  • write the detailed mechanism for the reaction of a carboxylic acid with thionyl chloride. (libretexts.org)
  • identify the reagents necessary to convert a given carboxylic acid to a given acid chloride, ester, amide or alcohol. (libretexts.org)
  • identify the carboxylic acid required for a direct synthesis of a given acid chloride, amide, ester or alcohol. (libretexts.org)
  • explain why the direct conversion of a carboxylic acid to an amide can only be achieved with difficulty and at a high temperature. (libretexts.org)
  • During the reaction the hydroxyl group of the carboxylic acid is converted to a chlorosulfite intermediate making it a better leaving group. (libretexts.org)
  • The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. (libretexts.org)
  • The direct conversion of a carboxylic acid to an amide is difficult because amines are basic and tend to convert carboxylic acids to their highly unreactive carboxylates. (libretexts.org)
  • In this reaction the carboxylic acid adds to the DCC molecule to form a good leaving group which can then be displaced by an amine during nucleophilic substitution. (libretexts.org)
  • Cyclohexane carboxylic acid accumulated to a concentration of 260 μM, accounting for about 18% of the initial benzoate added. (asm.org)
  • This study provides the first example of an efficient alkane hydrocarboxylation to carboxylic acid, in an ionic liquid and under mild conditions. (rsc.org)
  • The antibacterial erythromycin A, like other macrocyclic polyketides, is derived from simple carboxylic acid precursors by stepwise chain assembly on a modular polyketide synthase (PKS). (sciencemag.org)
  • A 5'-amine modified DNA oligonucleotide (5'-ACC AGC TGT GCA GGC CTC GC-3') purchased from Integrative DNA Technologies (Coralville, IA) was conjugated to the bifunctional linker 4-(maleimidomethyl)-1-cyclohexane carboxylic acid N-hydroxysuccinimide ester (SMCC, Sigma Aldrich) by combining 1 mL of SMCC (1 mg/mL) in acetonitrile with 2 mL of DNA (195 nmol) in 0.1 M KHPO4 buffer (pH 7.8). (psu.edu)
  • Tranexamic acid ( TXA ) is a medication used to treat or prevent excessive blood loss from major trauma , post partum bleeding , surgery, tooth removal , nose bleeds , and heavy menstruation . (wikipedia.org)
  • [3] [5] Tranexamic acid is in the antifibrinolytic family of medications. (wikipedia.org)
  • Tranexamic acid was discovered in 1962 by Utako Okamoto . (wikipedia.org)
  • [7] Tranexamic acid is available as a generic medication . (wikipedia.org)
  • Tranexamic acid is frequently used following major trauma. (wikipedia.org)
  • [10] Tranexamic acid is used to prevent and treat blood loss in a variety of situations, such as dental procedures for hemophiliacs, heavy menstrual bleeding, and surgeries with high risk of blood loss. (wikipedia.org)
  • Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma . (wikipedia.org)
  • Tranexamic acid is used to treat heavy menstrual bleeding. (wikipedia.org)
  • Tranexamic acid is used in orthopedic surgery to reduce blood loss, to the extent of reducing or altogether abolishing the need for perioperative blood collection. (wikipedia.org)
  • In the United States, tranexamic acid is FDA approved for short-term use in people with severe bleeding disorders who are about to have dental surgery. (wikipedia.org)
  • [20] Tranexamic acid is used for a short period of time before and after the surgery to prevent major blood loss and decrease the need for blood transfusions. (wikipedia.org)
  • In obstetrics, tranexamic acid is used after delivery to reduce bleeding, often with syntocinon/oxytocin and fundal massage. (wikipedia.org)
  • Each mL of the sterile solution for intravenous injection contains 100 mg tranexamic acid and Water for Injection to 1 mL. (rxlist.com)
  • Tranexamic acid is a white crystalline powder. (rxlist.com)
  • Thromboembolic events (e.g., deep vein thrombosis , pulmonary embolism , cerebral thrombosis, acute renal cortical necrosis, and central retinal artery and vein obstruction) have been rarely reported in patients receiving tranexamic acid for indications other than hemorrhage prevention in patients with hemophilia . (rxlist.com)
  • Tranexamic Acid BP2017 stock with comp. (lookchem.com)
  • Tranexamic Acid[CAS:1197-18-8/701-54-2. (lookchem.com)
  • Tranexamic Acid is only found in individuals that have used or taken this drug. (hmdb.ca)
  • PubChem]Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. (hmdb.ca)
  • Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation. (hmdb.ca)
  • Return to Tranexamic acid . (biology-online.org)
  • 7,8 Bleeding patients demonstrate increases in D-dimer and plasmin-antiplasmin complexes, both byproducts of fibrinolysis, compared to non-bleeding patients, and these increases are attenuated by treatment with tranexamic acid (TXA, Figure 1). (apsf.org)
  • 9 Tranexamic acid was developed in 1962 by Utako Okamoto, a Japanese scientist, in her pursuit of a pharmacologic treatment for postpartum hemorrhage. (apsf.org)
  • This paper demonstrates colorimetric visible spectrophotometric quantification methods for amino acid, namely, tranexamic acid and pregabalin. (hindawi.com)
  • The analytical methods under proposal were successfully applied to determine tranexamic acid and pregabalin in commercial products. (hindawi.com)
  • Primary objective of the study is to compare requirement of blood transfusion and mortality in patients receiving Tranexamic acid (Cyklokapron®) and those not receiving it. (clinicaltrials.gov)
  • It involved 274 hospitals across 40 countries and started in 2005 and concluded that tranexamic acid could safely reduce the risk of death in bleeding trauma patients.9 Intraoperative use of low dose tranexamic acid has been observed to be safe and effective in reducing the rate of perioperative blood transfusions in patients undergoing radical retropubic prostatectomy.10 It has also been approved by FDA for use in menorrhagia. (clinicaltrials.gov)
  • In this context, this study is undertaken to evaluate the efficacy of tranexamic acid in major gastrointestinal surgeries. (clinicaltrials.gov)
  • Investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements. (clinicaltrials.gov)
  • To comparatively study the effects of rPI-T1 with aprotinin and tranexamic acid, antifibrinolytic hemostatics currently used in clinical settings, by comparatively analyzing their inhibitory activities on plasmin, trypsin and kallikrein. (alliedacademies.org)
  • Tranexamic acid lysine analogues, on the other hand, had millimolar inhibitory concentrations because of different mechanism of action, i.e. noncompetitive inhibition. (alliedacademies.org)
  • Characterized by high inhibitory concentration and poor specificity, tranexamic acid is prone to cause severe side effects. (alliedacademies.org)
  • Under the same measurement conditions, inhibitory activities of rPI-T1, aprotinin and tranexamic acid on plasmin, trypsin and kallikrein were compared. (alliedacademies.org)
  • Novel poly(etherimide esters) are prepared by reacting a diol, a dicarboxylic acid, a poly(oxy alkylene) diamine and a tricarboxylic acid having two vicinal carboxyl groups or the anhydride thereof. (google.com)
  • S. aciditrophicus metabolizes various saturated and unsaturated fatty acids, methyl esters of butyrate and hexanoate, and benzoate in coculture with hydrogen/formate-using microorganisms. (asm.org)
  • Note that NaBH 4 is not strong enough to convert carboxylic acids or esters to alcohols. (libretexts.org)
  • Cyclohexanecarboxylic acid exhibits the reactions typical of carboxylic acids, including its conversion to the acid chloride cyclohexanecarbonyl chloride. (wikipedia.org)
  • The avermectins are a family of 16-membered macrocyclic lactones which are potent antiparasitic agents through their action as agonists of a γ-amino butyric acid-insensitive chloride channel ( 10 ). (sciencemag.org)
  • Pregabalin (PG) chemically is 3-amino methyl hexanoic acid, with the chemical formula C 8 H 17 NO 2 . (hindawi.com)
  • Shikimic acid, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. (sbwire.com)
  • A monocarboxylic acid amide obtained by the formal condensation of cyclohexanecarboxylic acid with the amino group of 5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-amine. (ebi.ac.uk)
  • Both drugs contain the amino group, and when they are reacted with 2,4-dinitrophenol and 2,4,6-trinitrophenol, they give rise to yellow colored complexes showing absorption maximum at 418 nm and 425 nm, respectively, based on the Lewis acid base reaction. (hindawi.com)
  • Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. (wikipedia.org)
  • Quinic acid is implicated in the perceived acidity of coffee. (wikipedia.org)
  • Quinic acid is also implicated in the perceived acidity of coffee. (wikipedia.org)
  • Dehydrogenation and oxidation of quinic acid affords gallic acid. (wikipedia.org)
  • Quinic acid is used as an astringent. (wikipedia.org)
  • Quinic acid is named on p. 167. (wikipedia.org)
  • D(-)-Quinic Acid is used in the synthesis of anti-influenza/anti-swine flu medication. (chemicalbook.com)
  • Quinic acid crystallises from H2O with m 174o, and from EtOH with m 168-169o. (chemicalbook.com)
  • Blakley E (1974) The microbial degradation of cyclohexanecarboxylic acid: a pathway involving aromatization to form p -hydroxybenzoic acid. (springer.com)
  • The anaerobic degradation of saturated fatty acids and aromatic acids in the absence of terminal electron processes necessitates the presence of a hydrogen-consuming organism to maintain a hydrogen partial pressure low enough for these reactions to be thermodynamically favorable ( 9 , 28 , 29 , 34 ). (asm.org)
  • An acid anhydride (or just anhydride) is the product of formal condensation of two oxoacid molecules with the release of a water molecule. (libretexts.org)
  • 7. The composition of claim 1 wherein the dicarboxylic acid component (b) is selected from the group consisting of C 2 to C 19 aliphatic, cycloaliphatic, and/or aromatic dicarboxylic acids, the ester equivalents thereof and mixtures thereof. (google.com)
  • Corey's "double activation" method for lactone formation is patterned after Mukaiyama's procedure for peptide formation and involves refluxing a solution of the 2-pyridinethiol ester of a hydroxy acid in a high-boiling solvent for a prolonged period of time. (orgsyn.org)
  • First, an ester such as the 1,1-dimethyl-ethylthiol ester serves as an excellent protective group, surviving both relatively mild alkaline and acid conditions, and has been used successfully in the synthesis of many macrolide natural products. (orgsyn.org)
  • Pune, Mahrashtra -- ( SBWIRE ) -- 03/28/2017 -- The motive of this strategic research report entitled "Global Shikimic Acid (CAS 138-59-0) Market 2017-2022" is to provide company officials, industry investors, and Shikimic Acid (CAS 138-59-0) industry members with consequential insights to enable them make reliable strategic decisions regarding the opportunities in the global Shikimic Acid (CAS 138-59-0) market. (sbwire.com)
  • Shikimic acid is mainly used as pharmaceutical intermediates, with a certain irritation. (sbwire.com)
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  • It is made synthetically by hydrolysis of chlorogenic acid. (wikipedia.org)
  • This acid is a versatile chiral starting material for the synthesis of pharmaceuticals. (wikipedia.org)
  • 16. The composition of claim 1 wherein the tricarboxylic acid (d) is characterized by the following formula: ##STR3## where R is a C 2 to C 20 trivalent aliphatic, cycloaliphatic or aromatic radical and R' is hydrogen or a C 1 to C 6 aliphatic radical. (google.com)
  • For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions. (rxlist.com)
  • However, a number of fatty acid- and aromatic acid-degrading syntrophic bacteria grow in pure culture by fermenting crotonate ( 6 , 24 , 46 , 48 ). (asm.org)
  • Although high levels of pyruvate blunted the inhibitory effectiveness of L-cycloserine, the results indicate that, under physiological conditions, alanine as well as branched chain amino acids are probably the predominant sources of glutamate nitrogen in ex vivo retinas. (biomedsearch.com)
  • Expression of this hybrid enzyme in the erythromycin producer Saccharopolyspora erythraea produced several novel antibiotic erythromycins derived from endogenous branched-chain acid starter units typical of natural avermectins. (sciencemag.org)
  • Cyclohexanecarboxylic acid is the organic compound with the formula C6H11CO2H. (wikipedia.org)
  • 2020. Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats. (uib.no)
  • 2019. Short-term activation of peroxisome proliferator-activated receptors α and γ induces tissue-specific effects on lipid metabolism and fatty acid composition in male Wistar rats. (uib.no)
  • 2018. Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. (uib.no)
  • 2018. A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. (uib.no)
  • Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. (biologists.org)
  • belongs to the class of organic compounds known as amino acids. (hmdb.ca)
  • Within the group of active compounds is a little-studied group previously associated with seizure control, and analysis of two of these compounds (nonanoic acid and 4-methyloctanoic acid) shows around a threefold enhanced potency compared with VPA for protection in an in vitro acute rat seizure model. (biologists.org)
  • Together, our data show that VPA and a newly identified group of medium-chain fatty acids reduce phosphoinositide levels independently of inositol regulation, and suggest the reinvestigation of these compounds as treatments for epilepsy. (biologists.org)
  • It is a Kunitz-type serine protease inhibitor containing 59 amino acids and 3 pairs of disulfide bonds, which has a molecular weight of about 6.7 kDa [ 3 , 4 ]. (alliedacademies.org)
  • 2-ethoxy-3- (4- (2- (4-methanesulfonyloxyphenyl) ethoxy) phenyl) propanoic acid crystalline form (s). (google.com)
  • 10. The composition of claim 9 wherein the predominant dicarboxylic acid is dimethyl terephthalate. (google.com)
  • 18. The composition of claim 1 wherein the weight ratio of the amount of dicarboxylic acid (b) used to the theoretical amount of poly(oxy alkylene) diimide diacid formable from the diamine (c) and tricarboxylic acid (d) is from about 0.25 to about 2.0. (google.com)
  • 19. The composition of claim 1 wherein the weight ratio of the amount of dicarboxylic acid (b) to the theoretical amount of poly(oxy alkylene) diimide diacid formable from the diamine (c) and tricarboxylic acid (d) is from about 0.4 to about 1.4. (google.com)
  • write an equation to represent the formation of a cyclic anhydride from a dicarboxylic acid. (libretexts.org)
  • Cyclohexanecarboxylic acid is a precursor to the nylon-6 precursor caprolactam via its reaction with nitrosylsulfuric acid. (wikipedia.org)
  • The fine suspension in the reaction flask is agitated and siphoned into a vigorously stirred mixture of 27 ml. (0.32 mole) (Note 5) of concentrated hydrochloric acid and 400 ml. of water. (orgsyn.org)
  • 5. The quantity of hydrochloric acid used is normally insufficient to neutralize all the lithium hydroxide produced when the reaction mixture is quenched in the aqueous solution. (orgsyn.org)
  • The excess trifluoroacetic acid and the water formed in the reaction were removed under reduced pressure. (orgsyn.org)
  • The most common anhydrides in organic chemistry are those derived from carboxylic acids at high temperatures to remove water. (libretexts.org)
  • This substance was isolated for the first time in 1806 by French pharmacist Nicolas Vauquelin and its transformation into hippuric acid by animal metabolism was studied by German chemist Eduard Lautemann in 1863. (wikipedia.org)
  • TXA-trans-4-aminoethyl cyclohexanecarboxylic acid-is a synthetic lysine analog. (apsf.org)
  • Consistent with the preference of K2 for binding 5-aminopentanoic acid over 6-aminohexanoic acid, the positions of the ionic centers within the K2 binding site approach each other approximately 1A closer relative to what is observed in lysine binding sites of homologous Pgn modules. (rcsb.org)