CycloheptanesMicrobubbles: Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Liquid Crystals: Materials in intermediate state between solid and liquid.Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Ethylene Dichlorides: Toxic, chlorinated, saturated hydrocarbons. Include both the 1,1- and 1,2-dichloro isomers. The latter is considerably more toxic. It has a sweet taste, ethereal odor and has been used as a fumigant and intoxicant among sniffers. Has many household and industrial uses.Hydrocarbons, HalogenatedEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Biodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Phycobilins: Open chain tetrapyrroles that function as light harvesting chromophores in PHYCOBILIPROTEINS.Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Brassica: A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Volatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Sulfur Oxides: Inorganic oxides of sulfur.Bankruptcy: The state of legal insolvency with assets taken over by judicial process so that they may be distributed among creditors.Spin Trapping: A technique for detecting short-lived reactive FREE RADICALS in biological systems by providing a nitrone or nitrose compound for an addition reaction to occur which produces an ELECTRON SPIN RESONANCE SPECTROSCOPY-detectable aminoxyl radical. In spin trapping, the compound trapping the radical is called the spin trap and the addition product of the radical is identified as the spin adduct. (Free Rad Res Comm 1990;9(3-6):163)Infant Formula: Liquid formulations for the nutrition of infants that can substitute for BREAST MILK.Sulfites: Inorganic salts of sulfurous acid.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.Ice: The solid substance formed by the FREEZING of water.Dry Ice: A solid form of carbon dioxide used as a refrigerant.Ice Cover: A thick mass of ICE formed over large regions of land; RIVERS; LAKES; ponds; or SEAWATER.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Freezing: Liquids transforming into solids by the removal of heat.Centers for Disease Control and Prevention (U.S.): An agency of the UNITED STATES PUBLIC HEALTH SERVICE that conducts and supports programs for the prevention and control of disease and provides consultation and assistance to health departments and other countries.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Quantitative Structure-Activity Relationship: A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.Alkanes: The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Complex Mixtures: Mixtures of many components in inexact proportions, usually natural, such as PLANT EXTRACTS; VENOMS; and MANURE. These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Alkane 1-Monooxygenase: A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as octane and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.HydrocarbonsPolymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Coordination Complexes: Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Polymerization: Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).

In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole. (1/66)

The antifungal activity of eberconazole, a new imidazole derivative, against 124 clinical isolates of Candida comprising eight different species and to 34 isolates of Cryptococcus neoformans was compared to those of clotrimazole and ketoconazole. MICs of eberconazole, determined by the National Committee for Clinical Laboratory Standards standardized microbroth method, were equal to or lower than those of other azoles, especially for Candida krusei and Candida glabrata, which are usually resistant to triazoles.  (+info)

Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest. (2/66)

We have found that the bicyclic colchicine analogue 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-on e (MTC) induced a dose- and time-dependent apoptotic response in human leukemic cells. MTC and colchicine rapidly disrupted the microtubule integrity and arrested cells at the G2-M phase before the onset of apoptosis. These responses were mediated by microtubule inhibition because 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)propionyl]amino]-2,4,6-cycloh eptatrien-1-one and lumicolchicine, inactive analogues of MTC and colchicine, respectively, were unable to promote microtubule disassembly, cell cycle arrest, and apoptosis. Although 1 microM MTC induced a complete microtubule disruption after 1 h of incubation in human leukemic HL-60 cells that led to an accumulation of cells at the G2-M phase, MTC-induced apoptosis occurred after 9 h of treatment. This indicates the existence of a rather long lag between microtubule disruption and the onset of apoptosis. Unlike colchicine, the removal of MTC during this lag resulted in rapid microtubule repolymerization, followed by restoration of normal cell cycle and cell growth. MTC, but not 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)-propionyl]amino]-2,4,6-cyclo heptatrien-1-one, induced c-jun expression as well as c-Jun NH2-terminal kinase and caspase activation, indicating that these signaling pathways are triggered by the specific action of MTC on microtubules. Caspase inhibition prevented MTC-induced apoptosis. Overexpression of bcl-2 or bcl-xL by gene transfer in human erythroleukemic HEL cells abrogated MTC-induced apoptosis, but cells remained arrested in G2-M, suggesting that bcl-2 and bcl-xL block the signaling pathway between G2-M arrest and triggering of apoptosis. MTC-treated bcl-2 and bcl-xL-transfected HEL cells recovered their capacity to proliferate after MTC removal. These results indicate that microtubule inhibition induces G2-M arrest and apoptosis in leukemic cells, showing a lag phase between G2-M arrest and the onset of apoptosis, regulated by bcl-2 and bcl-xL, during which MTC displays a reversible action on microtubule depolymerization and G2-M cell cycle arrest. Thus, MTC is a potent apoptotic inducer on human leukemic cells and shows a remarkable reversible action on microtubule network and cell cycle before commitment for apoptosis is reached.  (+info)

Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin. (3/66)

Gamma-thujaplicin and beta-dolabrin, the constituents of the wood of Thujopsis dolabrata Sieb. et Zucc. var. hondai showed strong in vitro cytotoxic effects against the human stomach cancer cell lines KATO-III and Ehrlich's ascites carcinoma. The cytotoxic effects of the two compounds against both tumor cell lines were clear when cell growth was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Gamma-thujaplicin and beta-dolabrin at 0.32 microg/ml inhibited cell growth of human stomach cancer KATO-III by 85 and 67%, and Ehrlich's ascites carcinoma by 91 and 75%, respectively. There is no large difference in cytotoxicity between these compounds, but the activity of gamma-thujaplicin was slightly more potent than that of beta-dolabrin. On the other hand, hinokitiol acetate did not show a cytotoxic effect, suggesting that at least a part of the mechanism of the cytotoxic effect of hinokitiol-related compounds is due to metal chelation between the carbonyl group at C-1 and the hydroxyl group at C-2 in the tropolone skeleton of these molecules. The acute toxicities [50% lethal dose (LD50) value: intraperitoneal injection, Van der Waedem] of gamma-thujaplicin and beta-dolabrin in mice were 277 mg/kg and 232 mg/kg, respectively.  (+info)

Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers. (4/66)

Five sesquiterpene alcohol esters of the carotane series, from plants of the genus Ferula, were investigated with regard to their capacity to modify the ion permeability of both planar lipid bilayers and mitochondria. These compounds are subdivided into two structural groups that differ in their effects on membrane permeability. Complex esters of sesquiterpene alcohols with aliphatic acids, which constituted the first group (lapidin and lapiferin), do not possess ionophoric properties. The second group comprised complex esters of sesquiterpene alcohols with aromatic acids (ferutinin, tenuferidin and ferutidin), all of which increase cation permeability of lipid bilayers and mitochondria in a dose-dependent manner. A pronounced selectivity of the terpenoid-modified membranes for divalent cations versus monovalent cations was found. Evidence of a carrier mechanism for terpenoid-induced ion transport is demonstrated. A tentative complex composed of a divalent cation with two molecules of membrane-active terpenoid is proposed.  (+info)

Antibacterial activity of tropolone. (5/66)

Tropolone was shown to be bacteriostatic and bactericidal for a wide range of bacterial species. This antibacterial activity was quantitated using standard methods. Tropolone treatment of whole cells resulted in cell lysis characterized by bleb formation and subsequent loss of cell contents after rupture of the bleb. Although bleb formation and lysis did not occur in the presence of 20% sucrose, cell viability was lost. Spheroplasts and protoplasts also lysed in the presence of tropolone. These results indicate that tropolone acts on the cell wall or envelope and on the plasma membrane.  (+info)

Studies on the subsite structure of amylases. I. Interaction of glucoamylase with substrate and analogues studied by difference-spectrophotometry. (6/66)

Studies were made on the ultraviolet difference-spectra of glucoamylase from Rhizopus niveus [EC 3.2.1.3] specifically produced by the substrate maltose and the inhibitors, glucose, glucono-1: 5-lactone (gluconolactone), methyl beta-D-glucoside, cellubiose, and cyclohexa-, and cyclohepta-amyloses. Of these, maltose and gluconolactone produced characteristic difference spectra with a trough near 300 nm. Based on studies with a model compound for a tryptophan residue, Ac-Trp, this trough was attributed to the effect of a negative charge upon the tryptophan residue. From the concentration dependency of the difference spectra, the dissociation constants of the complexes between the enzyme and maltose, glucose, and gluconolactone were evaluated to be 1.2 mM, 51 mM, and 1.5 mM, respectively. These values are in good agreement with the values of Km or K1 obtained from the steady-state kinetics. The difference-spectrophotometric data suggested that referring to the values of subsite affinities of glucoamylase, maltose, and gluconolactone occupy mainly Subsite 1, where the non-reducing-end glucose residue of a substrate is bound in a productive form and that a tryptophan residue with shows a trough near 300 nm in difference spectra is located in this subsite.  (+info)

Antibacterial activity of tropilidine and tropone. (7/66)

The seven-membered ring compounds tropilidine and tropone were shown to be bacteriostatic and bactericidal for a wide range of bacterial species.  (+info)

Alicyclobacillus herbarius sp. nov., a novel bacterium containing omega-cycloheptane fatty acids, isolated from herbal tea. (8/66)

A thermo-acidophilic gram-positive bacterium, strain CP-1T, which grows aerobically at 35-65 degrees C (optimum 55-60 degrees C) and at pH 3.5-6.0 (optimum pH 4.5-5.0), was isolated from a herbal tea made from the dried flowers of hibiscus. Phylogenetic analysis of the 16S rRNA gene sequences showed that this bacterium was clearly distinguishable from previously described species of the genera Alicyclobacillus and Sulfobacillus. Strain CP-1T had unique omega-cycloheptane fatty acids as the major membrane lipid component, a characteristic which is peculiar to Alicyclobacillus cycloheptanicus. However, phenotypic and chemotaxonomic characteristics of strain CP-1T were different from those of the type strain of A. cycloheptanicus. DNA-DNA hybridization between the type strains of Alicyclobacillus species and Sulfobacillus disulfidooxidans was <20%, indicating that strain CP-1T represents a distinct species. On the basis of these results, the name Alicyclobacillus herbarius is proposed for this organism. The type strain is strain CP-1T (= DSM 13609T = IAM 14883T = NRIC 0477T).  (+info)

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Journal Cover of Organic & Biomolecular Chemistry Congratulations to students Danielle Hirsch and Rajat Pal whose paper and artistic rendering of an hydroxytropolone bound to an enzyme of the herpes simplex virus has made the journal cover ... ...
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Azulene is a main component of chamomile extract which is used as a colouring agent (azul means blue in Spanish) in cosmetics and ointments and used as a folk medicine to treat migraine, arthritis, rheumatic diseases, and allergy. It has antioxidant and anti-inflammatory activities. Examples of common substituted azulenes obtained naturally are vetivazulene (4,8-dimethyl-2-isopropylazulene) from vetiver oil, and guaiazulene (1,4-dimethyl-7-isopropylazulene) from constituent of guaiac wood oil. Guaiazulene has been used as an antiulcer drug. Various biological activities such as antiphlogistic, antiallergic, bacteriostatic from azulen class compounds are expected. ...
Citation : Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M., Fiebich, B. L. and Munoz, E. (2004) Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochemical Pharmacology, 68 (5), pp. 875-883. ...
Citation: Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M., Fiebich, B. L. and Munoz, E. (2004) Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochemical Pharmacology, 68 (5), pp. 875-883. ...
Dwarf Western Red Cedar Thuja plicata Gruene Kugel is a slow growing, globe-shaped mound with thick, coarse looking foliage. The rich, dark green color of…
Compounds of formula (I): |p||chemistry id=CHEM-US-00001 num=00001||img id=EMI-C00001 he=33.70mm wi=69.85mm file=US20100105666A1-20100429-C00001.TIF img-content=chem img-format=tif ori
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
Azulene marine mousse (scrub). Physicochemicals elments of this product dragging deeply cleane the skin impurities that shrink daily. Due to contain azulene, prevents irritation and restores radiance and beauty to the face.. Algotonale scrub. The frequent use cleans pores in greasy skin. For its soft decaling action, it can be used in dry and brittle.. ...
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Discover 1520 Thuja Ave, Anchorage, AK 99507 - single family residence with 1,760 sq. ft., 3 beds, 2.0 baths. Get the latest property info at RealtyTrac - 3873362.
Helt enig med Ole Det er den temmelig sjældent selvsåede Alm. Thuja. Kun fundet i 20 ud af over 2000 AFD-ruder. På nærbillederne ser man de næsten leddelte kviste (som minder om en fladtrykt perlekæde) og den tydelige harpikskirtel på hvert (stort nok) skælblad. Nærbillederne bør i Galleriet. hilsen fra Henry ...
Ein Messer zum Zupacken und Strapazieren 4mm (!) starke 440-C-Klinge, rostfrei, hohlgeschliffen, feststellbar Griffh lften aus einem St ck Neusilber gesin
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Äggformad buske som blir ca 2 m högt. Växer ca 7 cm årligen. Marktäckande som växer ganska vertikalt. Ska planteras i soliga lägen.
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Pseudomonas putida strain M6 class 1 integron class 1 integrase (intI1) gene, partial cds, metallo-beta-lactamase GIM-1 (blaGIM-1), aminoglycoside-6N-acetyltransferase (aacA4), 3-(9)-O-adenylyltransferase (aadA1), and quaternary ammonium compound resistance protein (qacEdelta1) genes, complete cds, and dihydropteroate synthase (sul1) gene, partial ...
Looking for Thuja? Find out information about Thuja. a genus of monoecious arboreous plants of the family Cupressaceae, represented by one species, Thuja orientalis . The tree attains a height of 8-10 m, but... Explanation of Thuja
Ever golden, compact conifer is a quick grower with a stunning display of gold-yellow foliage that will not shed. Great orange Fall color with red stems in Fall and Winter.. ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
Define thuja: any of a genus (Thuja) of evergreen shrubs and trees (such as an arborvitae) of the cypress family that are native to North America and…
I have been a small upland organic farmer for more than 30 years, previously raising beef and currently farming sheep.. I cant remember when I first encountered the use of homeopathic thuja for treating Orf in sheep, but when many years ago my own sheep developed Orf I turned to thuja almost automatically. The more conventional veterinary world couldnt offer any treatment except, of course, antibiotics if secondary infection resulted. I did think critically about what I was doing, but - whilst being a ruthlessly sceptical person - I was open minded enough to recognise there was lot I did not understand, - and, - if something works there must be reason for it - even if I could not see how it was possible.. When I suffered prolapsed discs in my lower spine, the conventional medical world declared that the severity did not warrant an operation and so there was nothing else they could do. If I was to continue farming I needed to get better and so it was up to my body to heal itself. I went to see ...
1-(5-nitropyridin-2-yl)piperidin-4-amine 252577-85-8 NMR spectrum, 1-(5-nitropyridin-2-yl)piperidin-4-amine H-NMR spectral analysis, 1-(5-nitropyridin-2-yl)piperidin-4-amine C-NMR spectral analysis ect.
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Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner. Hernandez J, Fabelo C, Perez L, Moore C, Chang R, Wagner EJ. Biol Sex Differ. 2019 Feb 12;10(1):9. doi: 10.1186/s13293-019-0220-3. ...
United States Patent ()flice 3,382,248 6-AMINO-4,5-DI(SUBSTITUTED AMINO)-1,2-DIHY- DRO-1-HYDROXY-Z-IMINOPYRIMIDINES William C. Anthony, Kalamazoo, and Joseph J. Ursprung, Portage, Mich., assignors to The Upjohn Company, Kalamazoo, Mich., a corporation of Delaware No Drawing. Filed Nov. 1, 1965, Ser. No. 505,992 a 2 Claims. (Cl. 26 0-256.4) ABSTRACT OF THE DISCLOSURE 6-amino 1,2 dihydro-l-hydroxy-2-iminopyrimidines, their carboxylated counterparts, and the corresponding acid addition salts thereof are disclosed. These compounds, useful inter alia as hypertensive agents, bear a substituent in both the 4- and the 5-positions which is a secondary or a tertiary amino moiety. This invention relates to novel compositions of matter and to methods for producing them. In particular, this invention relates to novel 1,Z-dihydro-l-hydroxypyrimidines of the formula: wherein R is a moiety selected from the group consisting of moieties of the formula R4 R and R, can be alike or different. When R is a ...
Compactly branched shrub with handsome pointed globe shape, tips of soft green foliage is bright golden yellow. Turns bronzy coloring in winter. Use in pairs or groups in borders, in formal rows or containers. Full to partial sun. Slow growing 4 to 6 ft. tall, 3 to 5 ft. wide. No pruning necessary. Cutting grown.
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Tuja (lat. Thuja) je rod vždyzelených ihličnatých stromov. Rod tvorí 5 druhov, dva sa prirodzene vyskytujú v Severnej Amerike a tri vo východnej Ázii. Rod je monofyletický.. ...
More information about Thuja Plicata may be found here.. The Thuja Plicata is commonly known as the Arborvitae, Canoe-cedar, Giant Arborvitae, Giant Redcedar, Pacific Redcedar, Shinglewood, Western Red-cedar as well as Western Redcedar.. The currently accepted scientific name for western redcedar is Thuja plicata Donn ex D. Don . It is a member of the Cypress family (Cupressaceae). Western redcedar hybridizes with Thuja standishii. Hybrids are resistant to the leaf blight caused by Didymascella thujina . There are no recognized subspecies, varieties, or forms.. Western redcedar occurs along the Pacific Coast from the southern part of the Alaska Panhandle through British Columbia, western Washington, and western Oregon, reaching into the coastal redwood forest of northern California . Inland from the coast it occupies a contiguous band east of the Cascade Range from central Oregon to southern British Columbia . Much farther inland a disjunct population occurs along the west slopes of the Rocky ...
Thuja plicata - Western Red Cedar 1.75/2m tall is available to buy online, or for sale at our tree nursery in Essex near London - Thuja plicata - Western Red Cedar. Plant Information: Size: 1.
tats This invention relates to novel organometallic compounds and their preparation. More particularly, the present invention relates to novel and useful transition metal complexes of azulene. An object of this invention is to provide a novel class of organometallic compounds. Another object is to provide a class of stable transition metal coordination compounds of azulene. A further object is to provide a novel class of stable non-ionic azulene metal complexes having unsymmetric configurations. Other objects will become apparent from the specification and claims which follow. The above objects are accomplished by providing nonionic complex compounds of the metals of groups IVB- VIII in which a metal atom or atoms are bonded to azulene, which compound is stabilized by additional covalent bonding of the metal atom or atoms to dissimilar electron-donating groups. The metal in the novel compounds of this invention is a metal of groups IVBVIII of the periodic table as shown in The Handbook of Chem ...
Antiparkinsonian effects of tandospirone, a selective 5-HT1A receptor agonist, were evaluated using rat models of Parkinson's disease. Tandospirone reversed catalepsy induced by the D2 antagonist haloperidol, in a dose-dependent manner. The anti-cataleptic action of tandospirone was comparable to that of bromocriptine and greater than that of L-DOPA. In rats with unilateral dopaminergic lesion by 6-hydroxydopamine, tandospirone markedly induced contralateral rotation. Furthermore, tandospirone dose-dependently restored spontaneous locomotor activity in reserpine-treated rats. These antiparkinsonian effects of tandospirone were abolished by coadministration of WAY-100635, a selective 5-HT1A antagonist, but not by haloperidol. The present results suggest that tandospirone has a therapeutic potential in treating parkinsonian symptoms, which is brought about through activation of 5-HT1A receptor.
34 wax strips; 3 sizes. 34 wax strips total (17 double-sided), azulene finishing oil: 0.5 fl oz (14.7 ml), instructions. Brow. Face. Bikini. Results last up to 8 weeks (individual results may vary)! Ready and easy to use. Helps to slow the appearance of regrowth. Dermatologist & salon tested. No. 1 selling wax brand in the USA. Quick and easy. Results last up to 8 weeks (individual results may vary). 1-2-3 hair free! No microwave, no mess. 3 simple steps. Pre-waxed strips, pre-cut for face and bikini area. Works on short hair. Complete Kit Includes: three different sizes; azulene finishing oil; 4 large; 12 medium; 18 small. 34 wax strips (17 double-sided), azulene finishing oil. Scan here for how to use videos. 1 800 953 5080 (USA/Canada only). sallyhansen.com. Made in USA ...
Thuja plicata, commonly called western red cedar or giant red cedar, is native to the Pacific Northwest where it is typically found in cool but moist forest areas and bottomlands from southern Alaska along the Pacific coast to northern California and in the northern Rockies from British Columbia to Montana. This is the largest tree in the cypress family, growing in its native habitat to 100-200 tall and living from 400 to 1000+ years. It features horizontal branching with sprays of scale-like dark green foliage that is aromatic when crushed. Fibrous, aromatic, reddish-brown bark. Small, upright, light brown seed cones (to 1/2" long ...
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Meridian Botanicals Thuja Cedarwood essential oil (China) - 100% pure essential oil steam distilled from Thuja Cedarwood (Thuja orientalis) Suitable for all aromatherapy applications. Thuja Cedarwood is extremely balsamic and woody, with a smokey dry aroma, carrying with it a faint note of amyris or sandalwood. Thuja Cedarwood has a relaxing aroma, warming and soothing, and purifies the immediate surroundings. Origin: China Major
Autori: Alexandru C. Razus, Simona Nica, Liliana Cristian, Matei Raicopol, Liviu Birzan, Andreea Eugenia Dragu. Editorial: Elsivier, Dyes and Pigments, 91, p.55-61, 2011.. Rezumat:. Highly conjugated azo-aromatic systems have been prepared in high to moderate yields by linking mono- and bis-azo aromatic fragments to 4-(Rn-azulen-1-yl)-2,6-dimethyl-pyridine. The synthesized p-extended systems have been studied by NMR spectroscopy, UV-Vis and electrochemistry. Systematic increase of the conjugation along the azobenzene skeleton has affected the spectral properties of the azophenyl substituted 4-(azulen-1-yl)-pyridine. The synthesized compounds exhibit a bathochromic shift of the visible absorption maxima with the increase of the conjugating skeleton and introduction of an electron- ithdrawing group. The electrochemical behavior revealed a high stability toward oxidation owing to the higher polarization induced by the azulenyl-pyridine moiety.. Cuvinte cheie: Arylazo chromophores, Diazene ...
FREE DELIVERY to ANYWHERE in the UK Thuja trees make very good screening for unwanted views or an superb hedge, and are the best choice for a conifer hedge. As they will grow back strongly if cut right back or if a section is damaged, in comparison to most conifers that will not grow back from old stems. They also keep
An association between cardiac arrhythmias and ethanol use has been observed for some time. The sympathetic nervous system presumably plays an important role in the manifestation of cardiovascular...
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Ive seen western redcedar a thousand times, and I never really gave it a second glance. But my opinion of this tree changed on a recent trip I took to the Pacific Northwest - I had no idea these trees got so large!. I also decided that I really like the texture of this trees foliage - flat, waxy, pleasantly regularly notched. Touching objects around me, especially things with certain pattered textures, calms me and helps me focus. I wouldnt mind having more western redcedar around for this reason, in addition to its being such a beautiful tree.. ...
Thuja Green Giant Arborvitae Qty 5 Live Trees Evergreen Privacy - 2 Container by Florida Foliage at Think Earth Shop. Hurry! Limited time offer. Offer valid only while supplies last. 5 count trays of fully rooted 2 Thuja Arborvitae Green Giant trees. One of the finest evergreens for screening or windbreak, this upright conifer is versatile, strong-rooted and virtually disease-free. Its uniform shape seldom needs pruning, but responds well to shearing. Thuja Green Giant Arborvitae Thrives in southern hea
Nociceptin orphanin FQ (N/OFQ) is the 17 amino acid endogenous ligand for the Gi-coupled N/OFQ-receptor (NOP). In vivo administration produces a wide range of physiological responses including; analgesia, hyperalgesia and anti-opioid actions.;In a series of in vitro assays including [leucyl -3H]N/OFQ binding, GTPgamma[35S] binding and inhibition of cAMP formation the following linked studies were performed; (1)N/OFQ structure-activity relationships (SAR) in cells (CHO) stably expressing human NOP (2)evaluation of receptor density on efficacy using the ecdysone inducible expression system and native tissues, (3)an investigation of NOP/G-protein coupling efficiency.;SAR studies can be summarized as combining arginine14, lysine15 repeat in N/OFQ (increase affinity/potency) with C-terminal [F/G]N/OFQ(1--13)NH2([F/G]) and [Nphe1]N/OFQ(1--13)NH 2([Nphe1]) modifications (reduce/eliminate efficacy). Arg14/Lys15 increased the affinity (pKi:10.31--11.16) and potency (pEC50:8.98--9.85) of N/OFQ. [F/G] and ...
It is a vigorous, semi-evergreen, woody climber with long ascending (scandent) stems which if given the suitable support of a mature tree or tall wall is capable to reaching between 4.5-6 meters in height.. The leaves are narrowly triangular or ovate, coarsely toothed and sometimes lobed at the base. The small, bright yellow, almost daisy-like flower-heads are produced in large panicles (multi-branched cluster of flower) over the autumn - usually during October and November. The flowers have both male and female organs (hermaphrodite) and are insect pollinated.. Senecio scandens will tolerate most ordinary garden soils so long as they are moist and well-drained. It will do best when planted in a sunny, sheltered position although in cooler European climates it will be cut back down to the ground due by freezing temperatures. Be that as it may, it will usually grow back in the spring with renewed vigor. Senecio scandens will not perform well in the shade.. Given mild seasonal conditions, Senecio ...
To ensure that your Thuja hedge stays dense, it is important to take care of it. Thuja hedges can actually be pruned throughout the year - at frost-free temperatures. Nevertheless, January is well suited to cut back the plant, since it reduces its growth in the end of January. In February the plant grows more slowly which affects the healing process in a positive way. Do not choose a too sunny day. Best time is late afternoon. This way, the freshly cut wounds do not get burned and dry well ...
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Buy Owen Homoeopathics Thuja 6C 120 pilules from Kogan.com. Thuja has traditionally been used to assist in the management of wart like growths and a tendency to corns warts and calluses tinea and fungal like symptoms especially on the feet..
6-Piperidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide | C18H25F3N4O | CID 118736793 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The Plants Database includes the following 2 subspecies of Senecio serra . Click below on a thumbnail map or name for subspecies profiles ...
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Pernilla fra Filcolana er 100% ren ny uld i en smuk farveskala, som passer perfekt til lækre sweatre og børnetøj. Uldgarnet har en naturlig uldstruktur og er nemt både at strikke og hækle jævnt. Garnet egner sig godt til både sweatre, cardigans, mønsterstrik og interiør. Pernilla fra Filcolana strikkes på pinde 3.5-4.0
Arborvitae Trees are some of the best and most popular evergreen privacy tree there is. Order from NatureHills.com today and save up to 30%!
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The effects of free drug and tubulin-drug complexes on steady-state GTP/GDP-associated microtubules and on equilibrium guanosine 5-[beta,gamma-imido]triphosphate-associated microtubules are compared. The addition of colchicine or the tubulin-colchicine complex (TuCol) to steady-state microtubules induces microtubule disassembly. Only limited disassembly of equilibrium microtubules is observed under similar conditions. Addition of colchicine or the bifunctional colchicine analogue 2-methoxy-5-(2,3 ,4-trimethoxyphenyl) tropone to preassembled steady-state or equilibrium microtubules does induce disassembly, but establishment of the new steady state or equilibrium is very slow. These observations are related to the fact that TuCol readily adds to the microtubule end, but is only incorporated into the lattice with difficulty. As a result, microtubule growth is effectively inhibited and the critical concentration is significantly increased. Nevertheless, drug-induced disassembly can be extremely ...
Near-infrared (NIR) emitting lanthanide cations have a great potential for practical applications such as fluoroimmunoassays, polymer-based optical signal amplifiers, active materials in lasers, and bioimaging. In the recent years, the quest for new lanthanide-based NIR compounds has been one of the most active research areas in lanthanide coordination chemistry and spectroscopy. The first part of this dissertation describes the discovery of tropolonate, a novel and efficient sensitizer for five different NIR emitting lanthanide cations (Yb3+, Nd3+, Er3+, Tm3+, and Ho3+). The detailed structural and photophysical properties of the lanthanide complexes formed with tropolonate were investigated. On the basis of this initial work, four different approaches have been initiated with the goal to explore the possibilities to gain more control and to improve the luminescence properties of NIR emitting lanthanide compounds. 1) By the attachment of four tropolonate units to a common backbone to form ...
BioAssay record AID 342866 submitted by ChEMBL: Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to nociceptin/orphanin FQ (1-13)NH2 peptide.
español: senecio común, amargaza amarilla, azuzón, buen varón, cachapete, cachapetes, cachapetina, cardo santo, cineraria, flor de onse mesos, hierba blanca, hierbacana, hierba cana, hierba conejera, hierba de las quemaduras, hierba del gusano, hierba de los canarios, hirba cana, hoja del gusano, lechocino, morga, pamplina, pamplinas, pan de pájaro, panoyo, piapájaros, senecio, susón real, suzón, toribo, yerba cana, yuyito, ...
Central nociceptin/orphanin FQ (N/OFQ)-expressing neurones are abundantly expressed in the hypothalamus and limbic system and are implicated in the regulation of activity of the hypothalamic-pituitary-adrenal axis (HPA) and stress responses. We investigated the role of the endogenous N/OFQ receptor (NOP) system using the nonpeptidic NOP antagonist, JTC-801 [N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxy-methyl)benzamide monohydrochloride], during ...
Thuja (pronounced thu-ya) is traditionally considered the remedy to turn to for all instances of negative effects after vaccines (a condition called vaccinosis). Sig - Equestrian Store Equine Country Store
Two rat hearts were perfused in series by a modified Loewis method. The recipient heart was perfused with the perfusate collected from the donor heart. 1. After perfusion with 3H-isoprenaline in the presence of tropolone, an inhibitor of catechol-O-
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Nociceptin: | | | Nociceptin | | | | ||| ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor cloned in 1994 before identifying the endogenous ligand. Within a year, endogenous ligand was identified and soon many ligands were developed and evaluated in vitro and in vivo for NOP receptor distribution and activity. NOP receptor is widely distributed in brain, spinal cord and in peripheral organs such as heart, lungs, kidney, intestine and liver. Being a G-protein coupled receptor, its activation leads to changes in intracellular signal transduction mediated by adenylyl cyclase, Ca(2+) and K(+) ion channels, mitogen-activated kinase and phospholipase C. Based on preclinical studies, NOP receptor is implicated in regulation of pain, anxiety and depression, drug abuse, feeding, learning/memory, and motor activity.. Since the time of cloning the receptor and identification of endogenous ligand, numerous compounds have been designed targeting this receptor. However, there are no PET radioligands currently available ...
Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor cloned in 1994 before identifying the endogenous ligand. Within a year, endogenous ligand was identified and soon many ligands were developed and evaluated in vitro and in vivo for NOP receptor distribution and activity. NOP receptor is widely distributed in brain, spinal cord and in peripheral organs such as heart, lungs, kidney, intestine and liver. Being a G-protein coupled receptor, its activation leads to changes in intracellular signal transduction mediated by adenylyl cyclase, Ca(2+) and K(+) ion channels, mitogen-activated kinase and phospholipase C. Based on preclinical studies, NOP receptor is implicated in regulation of pain, anxiety and depression, drug abuse, feeding, learning/memory, and motor activity.. Since the time of cloning the receptor and identification of endogenous ligand, numerous compounds have been designed targeting this receptor. However, there are no PET radioligands currently available ...
DNA damage caused by ultraviolet (UV) irradiation can occur in various states of chromatin organization and is repaired mainly by nucleotide excision repair (NER). The ciliated protozoan Tetrahymena thermophila contains a transcriptionally silent germline micronucleus (MIC), where chromatin is relatively tight, and a transcriptionally active somatic macronucleus (MAC), where chromatin is relatively loose. This unique characteristic provides an opportunity to assess the effects of DNA repair at different states of chromatin organization. Genomic rearrangement occurs as portions of the MIC DNA are excised at specific internal eliminated sequences (IES) and removed prior to development of the new MAC DNA, and telomeres are added at chromosome breakage sites (CBS). The aim of this research was to investigate NER in T. thermophila by creating an assay that utilizes this genomic rearrangement to detect sites of DNA damage. An assay utilizing quantitative PCR (qPCR) and primers specific for the CBS locus Tt819
You may also wish to search for items by Kitagawa. 11 matching references were found. Kitagawa, T.; Harada, Y.; Inokuchi, H.; Kodera, K., Absorption spectrum of vapor phase azulene in vacuum ultraviolet region, J. Mol. Spectry., 1966, 19, 1. [all data] Kitagawa, T.; Inokuchi, H.; Kodera, K., Photoionization of polycyclic aromatic compounds in vacuum ultraviolet region. Azulene, J.Mol. Spectry., 1966, 21, 267. [all data] Kitagawa, T., Absorption spectra and photoionization of polycyclic aromatics in vacuum ultraviolet region, J. Mol. Spectry., 1968, 26, 1. [all data] Mori, Y.; Ogawa, Y.; Shinoda, H.; Kitagawa, T., Two competing fragmentation processes in dimethoxybenzenes depending on their positional isomers: Elimination of CH3 and CHnO (n = 1-3) and formation of methoxycyclopentadienyl and protonated phenol ions, Org. Mass Spectrom., 1992, 27, 578. [all data] Takeuchi, K.; Fujimoto, H.; Kitagawa, T.; Fujii, H.; Okamoto, K., Structural effects on valence tautomerism. Part 5. A carbon-13 nuclear ...
Thuja - cedar - are fast growing, evergreen conifers, they have compact yellowish green foliage that when crushed smells heavenly of pineapple. Buy this plant online at Grasslands or visit our nursery in Cheshire to find the plant in person.
In 6-OHDA-lesioned rats, repeated administration produces behavioral sensitization, manifested as a marked increase in l-Dopa-induced contralateral rotations across days of treatment (Henry et al., 1998). Behavioral sensitization has been suggested to predict the development of dyskinesias after chronic treatment with l-Dopa (Tronci et al., 2007). Here, we found that l-Dopa produced behavioral sensitization after only 4 days of treatment in 6-OHDA-lesioned rats. However, when l-Dopa was delivered concurrently with preladenant, the rats displayed no behavioral sensitization for as long as 23 days of treatment. The blockade of behavioral sensitization by preladenant in this model suggests that this agent may not only have antiparkinsonian effects on its own but also may reduce dyskinesias when used in combination with l-Dopa.. Aside from the motor symptoms that characterize PD, there are a collection of nonmotor symptoms that are not treated by current pharmacotherapies. One of the most severe is ...
The mechanisms for amantadines antiviral and antiparkinsonian effects are unrelated. The mechanism of amantadines antiviral activity involves interference with the viral protein, M2, a proton channel.[14][15] After entry of the virus into cells via endocytosis, it is localized in acidic vacuoles; the M2 channel functions in transporting protons with the gradient from the vacuolar space into the interior of the virion. Acidification of the interior results in disassociation of ribonucleoproteins, and the initiation of viral replication. Amantadine and rimantadine function in a mechanistically identical fashion in entering the barrel of the tetrameric M2 channel, and blocking pore function (i.e., proton translocation). Resistance to the drug class is a consequence of mutations to the pore-lining residues of the channel, leading to the inability of the sterically bulky adamantane ring that both amantadine and rimantadine share, in entering in their usual way, into the channel.[citation ...
We present the first use of in situ far-infrared spectroscopy to analyze the thermal amorphization of a zeolitic imidazolate framework material. We explain the nature of vibrational motion changes during the amorphization process and reveal new insights into the effect that temperature has on the Zn-N tetrah
Buy SBL Ointments Thuja, Purchase SBL Ointments Thuja Products Shop Order. Online Shopping with USA and Worldwide express shipping, purchase branded Beauty and Health, Ayurvedic and herbal. Shop Indian Products Online, Order SBL Ointments Homeopathy online store / shopping mall India. Emporiumonnet.com. Indian Store.
APG IV Classification: Domain: Eukaryota • (unranked): Archaeplastida • Regnum: Plantae • Cladus: angiosperms • Cladus: eudicots • Cladus: core eudicots • Cladus: superasterids • Cladus: asterids • Cladus: euasterids II • Ordo: Asterales • Familia: Asteraceae • Subfamilia: Asteroideae • Genus: Senecio • Species: Senecio glastifolius L.f. 1782 ...
Significant digging around on the Internet didnt reveal to me what "Yulan Oil" is or where it comes from. There is a Yulan Magnolia tree but whether this oil comes from that, I couldnt tell you. Its also not listed in the ingredients (which are Glycerin, Azulene, Collogen amino acids, Hyaluronic acid, Niacinamide, Gold, Morus Alba extract, Carbomer, Proplyene glycol, Purified Water) - But the "Morus Alba" is a white mullberry extract, which is good for skin, along with Hyraluronic Acid which is recommended for all sorts of discolouration - its not hard to see why this would work ...
If you live in a beachfront cottage, you can start every day with a nourishing mask of sea kelp. For the rest of us, there s this marine face wash. Rich in ingredients sourced from land and sea, it cleanses, calms, and conditions skin of any type. Aloe, rose hip, and algae extract provide a burst of moisture, sooth irritation, and minimize wrinkles, while Azulene and chamomile tame inflammation and lavender acts as an antiseptic.
Thujas 2002 album, Hills, emerged out of a particularly productive phase for the loose assemblage of musicians known as the Jewelled Antler Collective. Extant since the late 1990s, formed in San Francisco, Jewelled Antler had developed out of a certain disaffection with how independent music had ossified, become aesth
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The report generally describes n-(4-piperidin-1-ylbenzyl)-n-propylamine, examines its uses, production methods, patents. N-(4-PIPERIDIN-1-YLBENZYL)-N-PROPYLAMINE
The report generally describes 4-piperidin-4-ylpyrimidine, examines its uses, production methods, patents. 4-piperidin-4-ylpyrimidine market situation
In 1933, Hückel was still thinking about his molecular orbital electronic theory of benzene, but for ~15 years, there remained little need for the rule we now know as 4n+2, because n was invariably equal to 1 for most known aromatic molecules! It was only the discovery of so-called non-benzenoid aromatics in the 1940s (e.g. Dewars tropolone structure) that propelled chemists to identify aromatic molecules with other values of n. And Monastral blue is a prime example of n=4 (although it would be of interest to find out when it became so associated with the Hückel rule). If you count the red bonds above, there are eight, along with one lone pair of electrons located on the highlighted (blue) nitrogen atom. This makes 18 π-electrons in the ring, or 4×4+2 (there are paths other than the one shown, but they give the same count). Part of the reason for the remarkable thermal stability of this molecule must be its aromaticity.. So what about the colour? The visible spectrum is shown below, with ...
Buy high quality (E)-1,3-Bis(4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methoxyphenyl)prop-2-en-1-one from toronto research chemicals Inc.
- Weinstopper aus Edelstahl- Handgearbeiter Lebensbaum Griff- Made in Austria- Traumhafte Maserung- Handgefertigtes Unikat- Size: ca. 10 cmWeinstopsel aus Edelstahl mit Gummidichtung. Hinten mit wundervoll handgearbeiteten Holz Griff. Made in Austria und ein absolutes Unikat mit einer traumhaften Maserung Das Holz stammt selbstverstaendlich aus oesterreich - ist geschliffen und wurde anschliessend geoelt - also auch lebensmittelecht. Ein ideales Geschenk. Egal ob Weihnachten/Geburtstag und viele Anlaesse mehr. Lieferung im Stoffsackerl.
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Orphanin FQ antibody (prepronociceptin) for ICC/IF, IHC. Anti-Orphanin FQ pAb (GTX80752) is tested in Rat, Primate samples. 100% Ab-Assurance.
MolCore offers CAS No.57260-67-0, 1-(3,4-dichlorophenyl)piperazine for your research needs.Find product specific information including MFCD00023128,57260-67-0 MSDS,Price,Custom Synthesis.
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Electron transfer reactions have been studied between 9-anthracenecarboxylic acid co-adsorbed with perylene on silica gel surfaces employing azulene as a molecular shuttle in order to facilitate hole transfer. In this paper we present for the first time a ternary system that unambiguously demonstrates an appreciable mobility of radical cations on the silica gel surface. Rates of hole transfer from the 9-anthracenecarboxylic acid radical cation to perylene via azulene have been studied using diffuse reflectance laser flash photolysis spectroscopy. Azulene has been shown to enhance the rate of electron transfer in the ternary system, proving significant mobility of the azulene and its radical cation species on silica gel surfaces. The data shows that the azulene radical cation can diffuse at an appreciable rate on the silica gel surface ...
The product with fulvene 2 as the 6 π-e component and tropone as the 4 π-e component [6F+4T] is 3, while reversing their participation in the [6T+4F] cycloaddition leads to 4. A variety of [4+2] reactions are also possible. All of these reactions were investigated at PCM/M06-2X/6-311+G(d,p)//B3LYP-D3/6-31G(d). The reaction leading to 3 is exothermic by 3.0 kcal mol-1, while the reaction to 4 endothermic by 1.3 kcal mol-1.. Interestingly, there is only one transition state that leads to both 3 and 4, the first known bispericyclic transition state for two conjoined [6+4] cycloadditions. The barrier is 27.9 kcal mol-1. The structures of the two products and the transition state leading to them are shown in Figure 1. 3 and 4 can interconvert through a Cope transition state, also shown in Figure 1, with a barrier of 26.3 kcal mol-1 (for 4 → 3).. ...
Policalm™ Cream is easily applied to the skin and it has soothing and palliative properties in the areas showing signs of itching-pruritus.. Its unique formulation is rich in azulene, a-bisabolol (derived from chamomile), urea, polidocanol, calendula, coconut oil, menthol, aloe vera and panthenol.. The components of Policalm™ replenish, moisturize, relieve and soothe irritated skin areas with itching trends. They also keep the skin in good condition, helping to remove dead skin cells created on the surface of the skin which aggravate itching and leave a pleasant feeling.. Apply 1-2 doses in a skin area, making a light massage until completely absorbed. It is safe for frequent use.. If you have any queries please do not hesitate to contact your pharmacist or doctor or our company.. Keep out of the reach of children. Store in a cool & dry place below 28 °C. For external use only.. ...
Our previous data described significant differences between N/OFQ-induced food intake in DA and WOKW male rats [4]. Our concluding hypothesis was that N/OFQ-induced hyperphagia could be regulated by the Cart peptide. In the present study, in order to further explore this phenomenon, we extended inquiry to include female as well as male DA and WOKW rats, performing N/OFQ injections and analyzing their N/OFQ-induced food intake. We also looked at the Cart gene expression of their littermates. We observed significant differences in feeding behavior between DA and WOKW males, confirming data previously observed after injecting N/OFQ in the lateral ventricle. We also observed significant differences in N/OFQ-induced food intake between WOKW males and females after 1 h at a treatment of 0.5 nmol/rat. Looking at the Cart gene expression of littermates that were not part of the N/OFQ feeding behavior experiments, we noted that WOKW females have high Cart gene expression compared to WOKW males, while DA ...
TABLE-US-00001 TABLE 1 Cpd Name Structure 14 N-(1-benzylpiperidin-4-yl)-4-(1- benzylpiperidin-4-yloxy)-3- chlorobenzamide ##STR00025## 15 N-(1-benzylpiperidin-4-yl)-3- chloro-4-(1-((2,3- dihydrobenzo[b][1,4]dioxin-6- yl)methyl)piperidin-4- yloxy)benzamide ##STR00026## 16 N-(1-benzylpiperidin-4-yl)-4-(1- (4-tert-butylbenzyl)piperidin-4- yloxy)-3-chlorobenzamide ##STR00027## 17 N-(1-benzylpiperidin-4-yl)-3- chloro-4-(1-(4- (trifluoromethyl)phenyl)piperidin- 4-yloxy)benzamide ##STR00028## 18 N-(1-benzylpiperidin-4-yl)-3- chloro-4-(1-(4- (trifluoromethyl)benzoyl)piperidin- 4-yloxy)benzamide ##STR00029## 19 N-(1-benzylpiperidin-4-yl)-3- chloro-4-(1-(4- fluorobenzyl)piperidin-4- yloxy)benzamide ##STR00030## 20 N-(1-benzylpiperidin-4-yl)-3- fluoro-4-(1-(4-tert- butylbenzyl)piperidin-4- yloxy)benzamide ##STR00031## 21 N-(1-benzylpiperidin-4-yl)-3- fluoro-4-(1-(1- phenylethyl)piperidin-4- yloxy)benzamide ##STR00032## 22 N-(1-benzylpiperidin-4-yl)-3- chloro-4-(1-(4- fluorobenzoyl)piperidin-4- ...
... Information for Physicians. AnazaoHealth provides In-111 Oxine as a unit dose vial compounded for your patient.. Calibrated on Mondays.. Available Monday through Friday by Federal Express delivery.. Call for pricing.. Please contact AnazaoHealth for information about these products.. ...
Thuja, a bioactive derivative of Thuja occidentalis, has been widely accredited for its antitumorigenic potential (25,26). Although reports have verified the anticancer effect of this remedy (8-10), detailed reports elucidating the molecular mechanisms underlying the anticancer effect of thuja are needed. The present study demonstrated that the antitumorigenic effect of thuja on breast cancer cells was not a placebo effect as the placebo (potentized hydro-alcoholic solution)-treated cells failed to induce significant cell death when compared to the control cells. The present study further revealed that thuja asserted its effects by re-orienting the molecular choreography of cancer cells. Importantly, the preferential induction of the cytotoxic effects in breast cancer cells, as compared to normal cells, suggests a safe and non-toxic therapeutic opportunity.. It was shown that thuja is a potent inducer of apoptosis in mammary epithelial carcinoma cells, with a more pronounced effect in ...
The Pyrrolizidine Alkaloids (PAs) are a group of chemicals found in a variety of plant species throughout the world. These toxic alkaloids are distributed mainly in Senecio (Compositae), Crotalaria (Legominosae) and Heliotropium (Boraginaceae) species. Plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. Upon ingestion, metabolic activation in liver converts the potent compounds into highly reactive electrophiles capable of reacting with cellular macromolecules forming adducts, which can initiate acute or chronic toxicity. One of these plants is Senecio vulgaris which is abundant in wheat farms of Mazandaran province. When wheat (Triticum spp) is being harvested, seeds and aerial parts of Senecio would also be collected with it. Since the presence of PAs in Senecio vulgaris is proven in a previous research, hence in this study, quality and quantity of PAs of wheat and flour contaminated with Senecio in Mazandaran province farms have been studied
Diaphoretic, emmenagogue.. Uses: Thuja was an old North American Indian remedy for delayed menstruation; scientific research has shown that it is a stimulant to smooth muscles, such as those of the uterus and bronchial passages. Its stimulating expectorant effect is useful for treating bronchitis. Externally, herbalists use an infusion as a wash for infectious skin diseases such as impetigo or scabies. An ointment is reputed cure for warts. A hot compress eases rheumatic pains.. Warning Warning! Not to be used during pregnancy. Thujone, the main constituent of the volatile oil, is toxic in any quantity, so the herb should only be taken in small doses and for no more than a week or two at a time. Thuja should only be used as prescribed by a qualified practitioner.. ...
Cycloheptane Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ...
Cycloheptane. Cycloalkane C7H14. Methylcyclohexane. Cyclohexane C8H8. Cubane. Octane ...
Structurally, ecgonine is a cycloheptane derivative with a nitrogen bridge. It is obtained by hydrolysis of cocaine with acids ...
... cycloheptane, cyclooctane, and so on. Bicyclic alkanes include bicycloundecane, decalin, and housane.. Polycyclic alkanes ...
Cycloalkene Cyclopropane Cyclobutane Cyclopentane Cyclohexane Cycloheptane Cyclooctane IUPAC, Compendium of Chemical ... and cycloheptane), medium (cyclooctane through cyclotridecane), and large (all the rest). Each is an isomer of its alkene ...
It is characterized by an epoxide on the cycloheptane as well as an exocyclic methylene group that is conjugated with the ...
... cycloheptanes MeSH D02.455.426.392.368.284.049 --- azulenes MeSH D02.455.426.392.368.284.100 --- bencyclane MeSH D02.455. ...
... cycloheptane are the normal ones and the rest are the bigger ones. The naming of polycyclic alkanes is more complex, with the ...
... is a cycloalkane with the molecular formula C7H14. Cycloheptane is used as a nonpolar solvent for the chemical ... Cycloheptane vapour is irritating to the eyes and may cause respiratory depression if inhaled in large quantity. Mackay, Donald ...
The structure of a PAH influences whether and how the individual compound is carcinogenic.[51][55] Some carcinogenic PAHs are genotoxic and induce mutations that initiate cancer; others are not genotoxic and instead affect cancer promotion or progression.[55][56] PAHs that affect cancer initiation are typically first chemically modified by enzymes into metabolites that react with DNA, leading to mutations. When the DNA sequence is altered in genes that regulate cell replication, cancer can result. Mutagenic PAHs, such as benzo[a]pyrene, usually have four or more aromatic rings as well as a "bay region", a structural pocket that increases reactivity of the molecule to the metabolizing enzymes.[57] Mutagenic metabolites of PAHs include diol epoxides, quinones, and radical PAH cations.[57][58][59] These metabolites can bind to DNA at specific sites, forming bulky complexes called DNA adducts that can be stable or unstable.[53][60] Stable adducts may lead to DNA replication errors, while unstable ...
In systematic chemical nomenclature, alkynes are named with the Greek prefix system without any additional letters. Examples include ethyne or octyne. In parent chains with four or more carbons, it is necessary to say where the triple bond is located. For octyne, one can either write 3-octyne or oct-3-yne when the bond starts at the third carbon. The lowest number possible is given to the triple bond. When no superior functional groups are present, the parent chain must include the triple bond even if it is not the longest possible carbon chain in the molecule. Ethyne is commonly called by its trivial name acetylene.. In chemistry, the suffix -yne is used to denote the presence of a triple bond. In organic chemistry, the suffix often follows IUPAC nomenclature. However, inorganic compounds featuring unsaturation in the form of triple bonds may be denoted by substitutive nomenclature with the same methods used with alkynes (i.e. the name of the corresponding saturated compound is modified by ...
There are two principal commercial uses of 1-MCP: maintaining the freshness of ornamental plants and flowers, and preventing the ripening of fruits. In each case, 1-MCP is combined with other materials for handling and then mixed with a specific amount of water or other solution to release it into the air.[9] It is used in enclosed indoor sites, such as coolers, truck trailers, greenhouses, storage facilities, and shipping containers.[9] Under the brand name EthylBloc, 1-MCP was approved by the U.S. Environmental Protection Agency for use on ornamental crops.[10] It is used with cut flowers, potted flowers, and bedding, nursery and foliage plants to prevent premature wilting, leaf yellowing, premature opening, and premature death.[11][12] Under the brand name SmartFresh, 1-MCP is used in the agriculture industry by growers, packers, and shippers to maintain the quality of fruits and vegetables by preventing or delaying the natural ripening process. The use of 1-MCP in agricultural products ...
Finke, H.L.; Scott, D.W.; Gross, M.E.; Messerly, J.F.; Waddington, G., Cycloheptane, Cyclooctane and 1,3,5-Cycloheptatriene. ... Finke, H.L.; Scott, D.W.; Gross, M.E.; Messerly, J.F.; Waddington, G., Cycloheptane, cyclooctane and 1,3,5-cycloheptatriene. ... Finke, H.L.; Scott, D.W.; Gross, M.E.; Messerly, J.F.; Waddington, G., Cycloheptane, cyclooctane and 1,3,5-cycloheptatriene. ... Haines, J.; Gilson, D.F.R., Investigation of the phase transition behavior in solid cycloheptane, J. Phys. Chem., 1990, 94, ...
Cycloheptane is a cycloalkane with the molecular formula C7H14. Cycloheptane is used as a nonpolar solvent for the chemical ... Cycloheptane vapour is irritating to the eyes and may cause respiratory depression if inhaled in large quantity. Mackay, Donald ...
Cycloheptane Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ...
perfluoro cycloheptanes, C7F14 perfluoro methyl cyclohexanes, C7F14 ...
Cycloheptane, bromo-. Undecane, 3-methyl-. Benzene, (1-ethyl-1-propenyl)-. Cyclohexane, hexyl-. ... is cycloheptane, bromo- respectively. The yields of the liquid hydrocarbons were higher with CuCO3 catalyst than non-catalyst ...
cycloheptane ?????????? cycloheptyl ?????????? , 7 13 cyclohexadienyl ???????????????? (??????? ????????????? ). ...
Cycloheptane. Cycloalkane C7H14. Methylcyclohexane. Cyclohexane C8H8. Cubane. Octane ...
... alicyclic hydrocarbons such as cyclohexane and cycloheptane; cyclic ethers such as tetrahydrofuran and dioxane; ethers such as ... alicyclic hydrocarbons such as cyclohexane and cycloheptane; cyclic ethers such as tetrahydrofuran and dioxane; ethers such as ...
There is a slight amount of strain energy in cycloheptane and larger cycloalkanes, since it is difficult for them to adopt bond ...
Cycloheptane: chair conformation. Cycloheptane: boat conformation. Cycloheptane: equatorial form. Cyclooctane: chair ...
Step 1: [(4-Bromophenyl)(phenyl)methylene]cycloheptane (1). To a stirred suspension of Zn powder (4.80 g, 73.5 mmol) and THF ( ... A suspension of [(4-Bromophenyl)(phenyl)methylene]cycloheptane (1) (0.50 g, 1.47 mmol), TEA (1.21 mL, 8.71 mmol), acrylamide ( ...
A) 1-butyl-3-methyl-5-ethyl cycloheptane. Explain. The ring is made by seven carbons so its cyclo heptane. First point have ...
cycloheptane. What is the name of C7H14. 300. Cobalt (II) Oxide. What is the name of CoO? ...
cycloheptane. 291-64-5. Intradiffusion Coefficient: D2T (x i ); T = 298.2 K; Method: NMR PG ...
Background NMDA receptor modulation by hydrocarbons is associated with a molar water solubility cut-off. Low-affinity phenolic modulation of GABAAreceptors is also associated with a cut-off, but at...
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Cycloheptane, (heptadecafluorooctyl)-. C15H13F17. 172366-93-7. Benzofuran, 2-(ethylthio)-. C10H10OS. 172366-46-0. ...
Cycloheptane monoterpenoids [PR010211]. Bicyclic monoterpenoids [PR010212]. Tricyclic monoterpenoids [PR010213]. Other ...
Prenol Lipids [PR] (W) Isoprenoids [PR01] C10 isoprenoids (monoterpenes) [PR0102] Cycloheptane monoterpenoids [ ...
Cycloheptane/Liquid nitrogen -12. Benzonitrile/Liquid nitrogen -13. Ethylene glycol/Dry ice -15. o-Dichlorobenzene/Liquid ...
Cycloheptane (l). C7H14. -156.6. Cycloheptane (g). C7H14. -118.1. Ethylcyclopentane (l). C7H14. -163.4. 279.9. ...
High Performance Liquid Chromatography High Performance Liquid Chromatography Topological Index Cycloalkanes Cycloheptane ...
... cycloheptane, methylcyclohexane, methylcycloheptane, and mixtures thereof; perfluorinated hydrocarbons such as perfluorinated C ... cycloheptane, methylcyclohexane, methylcycloheptane, and mixtures thereof; aromatic and hydrocarbyl-substituted aromatic ... cycloheptane, methylcyclohexane, methylcycloheptane, and mixtures thereof, aromatic and hydrocarbyl-substituted aromatic ...
  • Given the wide occurrence of cycloheptane containing compounds in nature, and the group's ongoing interest in acetylene-Co2(CO)6 chemistry, the following chapters describe a novel approach to cycloheptyne-Co2(CO)6 synthesis via the preparation and reactivity studies of vinylogous propargyl acetate-Co2(CO)6 complexes. (uwindsor.ca)