A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.
Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.
Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.
Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.
A phenothiazine derivative that is used as an antipruritic.
Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.
A measure of relative protection provided by SUNSCREENING AGENTS against burns due to ultraviolet (UV) radiation from a light source.
The rotation of linearly polarized light as it passes through various media.
Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.
The chemical and physical integrity of a pharmaceutical product.
An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
The thermodynamic interaction between a substance and WATER.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic.
Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)
The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.
Shortened forms of written words or phrases used for brevity.
An enzyme that catalyzes the hydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides and oligosaccharides so as to remove successive beta-maltose units from the non-reducing ends of the chains. EC 3.2.1.2.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
The privacy of information and its protection against unauthorized disclosure.
Legal guarantee protecting the individual from attack on personal liberties, right to fair trial, right to vote, and freedom from discrimination on the basis of race, color, religion, sex, age, disability, or national origin. (from http://www.usccr.gov/ accessed 1/31/2003)
The freedom of patients to review their own medical, genetic, or other health-related records.
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Discarded animal and vegetable matter from a kitchen or the refuse from food preparation. (From Random House College Dictionary, 1982)
Barriers used to separate and remove PARTICULATE MATTER from air.
Inanimate objects that carry pathogenic microorganisms and thus can serve as the source of infection. Microorganisms typically survive on fomites for minutes or hours. Common fomites include CLOTHING, tissue paper, hairbrushes, and COOKING AND EATING UTENSILS.
Disposal, processing, controlling, recycling, and reusing the solid, liquid, and gaseous wastes of plants, animals, humans, and other organisms. It includes control within a closed ecological system to maintain a habitable environment.
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Volunteer organizations whose members perform work for the hospital without compensation.
Personnel whose work is prescribed and supervised by the dentist.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)

Thermus aquaticus ATCC 33923 amylomaltase gene cloning and expression and enzyme characterization: production of cycloamylose. (1/768)

The amylomaltase gene of the thermophilic bacterium Thermus aquaticus ATCC 33923 was cloned and sequenced. The open reading frame of this gene consisted of 1,503 nucleotides and encoded a polypeptide that was 500 amino acids long and had a calculated molecular mass of 57,221 Da. The deduced amino acid sequence of the amylomaltase exhibited a high level of homology with the amino acid sequence of potato disproportionating enzyme (D-enzyme) (41%) but a low level of homology with the amino acid sequence of the Escherichia coli amylomaltase (19%). The amylomaltase gene was overexpressed in E. coli, and the enzyme was purified. This enzyme exhibited maximum activity at 75 degrees C in a 10-min reaction with maltotriose and was stable at temperatures up to 85 degrees C. When the enzyme acted on amylose, it catalyzed an intramolecular transglycosylation (cyclization) reaction which produced cyclic alpha-1,4-glucan (cycloamylose), like potato D-enzyme. The yield of cycloamylose produced from synthetic amylose with an average molecular mass of 110 kDa was 84%. However, the minimum degree of polymerization (DP) of the cycloamylose produced by T. aquaticus enzyme was 22, whereas the minimum DP of the cycloamylose produced by potato D-enzyme was 17. The T. aquaticus enzyme also catalyzed intermolecular transglycosylation of maltooligosaccharides. A detailed analysis of the activity of T. aquaticus ATCC 33923 amylomaltase with maltooligosaccharides indicated that the catalytic properties of this enzyme differ from those of E. coli amylomaltase and the plant D-enzyme.  (+info)

Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (2/768)

GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents.  (+info)

Antilithiasic effect of beta-cyclodextrin in LPN hamster: comparison with cholestyramine. (3/768)

Beta-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs. This study examined the effects of BCD as compared with cholestyramine on cholesterol and bile acid metabolism in the LPN hamster model model for cholesterol gallstones. The incidence of cholesterol gallstones was 65% in LPN hamsters fed the lithogenic diet, but decreased linearly with increasing amounts of BCD in the diet to be nil at a dose of 10% BCD. In gallbladder bile, cholesterol, phospholipid and chenodeoxycholate concentrations, hydrophobic and lithogenic indices were all significantly decreased by 10% BCD. Increases in bile acid synthesis (+110%), sterol 27-hydroxylase activity (+106%), and biliary cholate secretion (+140%) were also observed, whereas the biliary secretion of chenodeoxycholate decreased (-43%). The fecal output of chenodeoxycholate and cholate (plus derivatives) was increased by +147 and +64%, respectively, suggesting that BCD reduced the chenodeoxycholate intestinal absorption preferentially. Dietary cholestyramine decreased biliary bile acid concentration and secretion, but dramatically increased the fecal excretion of chenodeoxycholate and cholate plus their derivatives (+328 and +1940%, respectively). In contrast to BCD, the resin increased the lithogenic index in bile, induced black gallstones in 34% of hamsters, and stimulated markedly the activities of HMG-CoA reductase (+670%), sterol 27-hydroxylase (+310%), and cholesterol 7alpha-hydroxylase (+390%). Thus, beta-cyclodextrin (BCD) prevented cholesterol gallstone formation by decreasing specifically the reabsorption of chenodeoxycholate, stimulating its biosynthesis and favoring its fecal elimination. BCD had a milder effect on lipid metabolism than cholestyramine and does not predispose animals to black gallstones as cholestyramine does in this animal model.  (+info)

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. (4/768)

The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell lines by using methyl-beta-cyclodextrin (MbetaCD) to selectively extract cholesterol from the plasma membrane. MbetaCD treatment strongly inhibited endocytosis of transferrin and EGF, whereas endocytosis of ricin was less affected. The inhibition of transferrin endocytosis was completely reversible. On removal of MbetaCD it was restored by continued incubation of the cells even in serum-free medium. The recovery in serum-free medium was inhibited by addition of lovastatin, which prevents cholesterol synthesis, but endocytosis recovered when a water-soluble form of cholesterol was added together with lovastatin. Electron microscopical studies of MbetaCD-treated HEp-2 cells revealed that typical invaginated caveolae were no longer present. Moreover, the invagination of clathrin-coated pits was strongly inhibited, resulting in accumulation of shallow coated pits. Quantitative immunogold labeling showed that transferrin receptors were concentrated in coated pits to the same degree (approximately sevenfold) after MbetaCD treatment as in control cells. Our results therefore indicate that although clathrin-independent (and caveolae-independent) endocytosis still operates after removal of cholesterol, cholesterol is essential for the formation of clathrin-coated endocytic vesicles.  (+info)

V-Amylose at atomic resolution: X-ray structure of a cycloamylose with 26 glucose residues (cyclomaltohexaicosaose). (5/768)

The amylose fraction of starch occurs in double-helical A- and B-amyloses and the single-helical V-amylose. The latter contains a channel-like central cavity that is able to include molecules, "iodine's blue" being the best-known representative. Molecular models of these amylose forms have been deduced by solid state 13C cross-polarization/magic angle spinning NMR and by x-ray fiber and electron diffraction combined with computer-aided modeling. They remain uncertain, however, as no structure at atomic resolution is available. We report here the crystal structure of a hydrated cycloamylose containing 26 glucose residues (cyclomaltohexaicosaose, CA26), which has been determined by real/reciprocal space recycling starting from randomly positioned atoms or from an oriented diglucose fragment. This structure provides conclusive evidence for the structure of V-amylose, as the macrocycle of CA26 is folded into two short left-handed V-amylose helices in antiparallel arrangement and related by twofold rotational pseudosymmetry. In the V-helices, all glucose residues are in syn orientation, forming systematic interglucose O(3)n...O(2)(n+l) and O(6)n...O(2)(n+6)/O(3)(n+6) hydrogen bonds; the central cavities of the V-helices are filled by disordered water molecules. The folding of the CA26 macrocycle is characterized by typical "band-flips" in which diametrically opposed glucose residues are in anti rather than in the common syn orientation, this conformation being stabilized by interglucose three-center hydrogen bonds with O(3)n as donor and O(5)(n+l), O(6)(n+l) as acceptors. The structure of CA26 permitted construction of an idealized V-amylose helix, and the band-flip motif explains why V-amylose crystallizes readily and may be packed tightly in seeds.  (+info)

Cell cholesterol efflux: integration of old and new observations provides new insights. (6/768)

Numerous studies using a variety of cell/acceptor combinations have demonstrated differences in cholesterol efflux among cells. These studies also show that different acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux through a variety of mechanisms. By combining early observations with data derived from recent studies, it is now possible to formulate a model for cell cholesterol efflux which proposes that an array of different mechanisms, including aqueous diffusion, lipid-free apolipoprotein membrane microsolubilization, and SR-BI-mediated cholesterol exchange contribute to cholesterol flux. In this model the relative importance of each mechanism would be determined both by the cell type and the nature of the extracellular cholesterol acceptor.  (+info)

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. (7/768)

CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low density lipoprotein (OxLDL), and may potentially play a role in the development of atherosclerosis. We reported that the native and modified low density lipoproteins increased CD36 mRNA and protein ( J. Biol. Chem. 272: 21654-21659). In this study, we investigated the effect of alterations of cellular cholesterol content on macrophage expression of CD36. Depletion of cholesterol by treatment with beta-cyclodextrins (beta-cyclodextrin [beta-CD] and methylated beta-cyclodextrin [MebetaCD]) significantly decreased CD36 mRNA and 125I-labeled OxLDL binding. Conversely, loading macrophages with cholesterol or cholesteryl ester (acetate) with MebetaCD:cholesterol complexes increased CD36 mRNA, 125I-labeled OxLDL binding, and CD36 surface expression as determined by fluorescence activated cell sorting. Thus, CD36 expression paralleled cellular cholesterol levels after removal of cholesterol with beta-cyclodextrins or addition of cholesterol with MebetaCD:cholesterol complexes. Neither cholesterol depletion nor loading altered expression of type A scavenger receptor mRNA. Kinetics studies showed that changes in CD36 mRNA occurred after changes of cellular cholesterol. Neither beta-cyclodextrins nor MebetaCD:cholesterol altered CD36 mRNA half-life in the presence of actinomycin D, suggesting that alterations in CD36 expression by cholesterol occur at the transcriptional level. These experiments demonstrate that CD36 expression is enhanced by cholesterol and down-regulated by cholesterol efflux, and imply that macrophage expression of CD36 and foam cell formation in atherosclerotic lesions may be perpetuated by a cycle in which lipids drive expression of CD36 in a self-regulatory manner.  (+info)

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. (8/768)

Tyrosine phosphorylation of the high affinity immunoglobulin (Ig)E receptor (FcepsilonRI) by the Src family kinase Lyn is the first known biochemical step that occurs during activation of mast cells and basophils after cross-linking of FcepsilonRI by antigen. The hypothesis that specialized regions in the plasma membrane, enriched in sphingolipids and cholesterol, facilitate the coupling of Lyn and FcepsilonRI was tested by investigating functional and structural effects of cholesterol depletion on Lyn/FcepsilonRI interactions. We find that cholesterol depletion with methyl-beta-cyclodextrin substantially reduces stimulated tyrosine phosphorylation of FcepsilonRI and other proteins while enhancing more downstream events that lead to stimulated exocytosis. In parallel to its inhibition of tyrosine phosphorylation, cholesterol depletion disrupts the interactions of aggregated FcepsilonRI and Lyn on intact cells and also disrupts those interactions with detergent-resistant membranes that are isolated by sucrose gradient ultracentrifugation of lysed cells. Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions. These results provide strong evidence that membrane structure, maintained by cholesterol, plays a critical role in the initiation of FcepsilonRI signaling.  (+info)

The solubility of natural cyclodextrins is very poor and initially this prevented cyclodextrins from becoming effective complexing agents. In the late 1960s, it was discovered that chemical substitutions at the 2-, 3-, and 6-hydroxyl sites would greatly increase solubility. The degree of chemical substitution and the nature of the groups used for substitution determine the final maximum concentration of cyclodextrin in an aqueous medium. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.. Cavity size is the major determinant as to which cyclodextrin is used in complexation. Fit is critical to achieving good incorporation of cyclodextrins. α-Cyclodextrins have small cavities that are not capable of accepting many molecules. γ-Cyclodextrins have much larger cavities than many molecules to be incorporated, and cyclodextrin hydrophobic charges cannot effectively interact to facilitate complexation. The cavity diameter of β-cyclodextrins has been ...
In vitro studies of α-amylase degradation of α-, β- and γ-cyclodextrins and 2-hydroxypropyl-β- and -γ-cyclodextrins were investigated spectrophotometrically by measuring the formation of reducing sugars, the reaction products of α-amylase degradation. This was done to evaluate potential degradation and thereby biological conversion of the cyclodextrins if dosed orally, as the intestinal tract contains α-amylase for digestive purposes. The results demonstrated that only γ- and 2-hydroxypropyl-γ-cyclodextrins can be degraded by α-amylase to a relevant extent, that is, γ- and 2-hydroxypropyl-γ-cyclodextrins have different biopharmaceutical behaviours than the other evaluated cyclodextrins. The rate of degradation was affected by the addition of the inclusion complex forming additives flurbiprofen, ibuprofen and benzo[a]pyrene. This effect between the degradation dynamics and the included additives was caused by a correlation between solubility of the additives and the stability of the ...
The aim of present study is to highlight the effects of β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HBCD) and also the effect of their concentrations and methods of inclusion complexation on solubility and antibacterial activity of trimethoprim [TMP] by inclusion complex formation. The inclusion complexes of TMP were prepared by solvent evaporation, spray drying, kneading and physical mixture methods in 1:1 and 1:2 ratios. The inclusion complexes were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), dissolution study and antimicrobial activity by disk diffusion method. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) results proved formation of inclusion complex of TEM with cyclodextrins. XRD showed decrease in crystanality of TEM after complexation with CDs. The results of saturation solubility study and release study prevailed the more increase in solubility of TMP by HPCD than
TY - JOUR. T1 - Interactions between cyclodextrins and cell-membrane phospholipids. AU - Szejtli, J.. AU - Cserháti, T.. AU - Szögyi, M.. PY - 1986. Y1 - 1986. N2 - The interactions between cyclodextrins (CDs) and selected cell membrane phospholipids, liposomes and human erythrocytes were studied. Non-methylated cyclodextrins did not influence the differential scanning calorimetric behaviour of phospholipids and did not increase the permeability of dipalmitoyl-phosphatidyl-choline liposomes. Dimethyl- and trimethyl- β-CD interacted with the phospholipids but the effect was negligible compared to the effect of valinomycin. Reversed-phase thin-layer chromatography revealed complex formation with dimethyl-β-cyclodextrin, but not with others. The addition of cyclodextrins up to 10-2 mol litre-1 concentration did not modify the active or passive alkali ion transport of human erythrocytes, however, higher concentrations of added β-cyclodextrin especially dimethyl-β-cyclodextrin resulted in ...
Effect of processing variables on dissolution and solubility of piroxicam: Hydroxypropyl-? -cyclodextrin inclusion complexes Abstract.
Formation of maltosyl cyclodextrins from mixtures of maltose and cyclodextrins by reverse reactions of Flavobacterium isoamylase and Klebsiella pullulanase was experimented and it was found that Klebsilla pullulanase produced 50.4 mg maltosyl alpha-cyclodextrin, 35.0 mg maltosyl beta-cyclodextrin and 55.4 mg maltosyl gamma-cyclodextrin per ml of reaction mixture, whereas Flavobacterium isoamylase did not form maltosyl cyclodextrins. Optimum conditions for formation of maltosyl beta-cyclodextrin by Klebsiella pullulanase were pH 4, 50 degrees C reaction temperature and proportion of substrate 100 mg beta-cyclodextrin/600 mg maltose per ml ...
0083] In some embodiments, the cyclodextrin derivative is present in a pharmaceutical composition or unit dosage form of the present invention in a concentration of about 0.1 mg/mL to about 1000 mg/mL, about 0.1 mg/mL to about 700 mg/mL, about 0.1 mg/mL to about 500 mg/mL, about 0.1 mg/mL to about 250 mg/mL, about 0.1 mg/mL to about 200 mg/mL, about 0.1 mg/mL to about 150 mg/mL, about 0.1 mg/mL to about 100 mg/mL, about 0.1 mg/mL to about 50 mg/mL, about 1 mg/mL to about 1000 mg/mL, about 1 mg/mL to about 700 mg/mL, about 1 mg/mL to about 500 mg/mL, about 1 mg/mL to about 250 mg/mL, about 1 mg/mL to about 200 mg/mL, about 1 mg/mL to about 150 mg/mL, about 1 mg/mL to about 100 mg/mL, about 1 mg/mL to about 50 mg/mL, about 10 mg/mL to about 1000 mg/mL, about 10 mg/mL to about 700 mg/mL, about 10 mg/mL to about 500 mg/mL, about 10 mg/mL to about 250 mg/mL, about 10 mg/mL to about 200 mg/mL, about 10 mg/mL to about 150 mg/mL, about 10 mg/mL to about 100 mg/mL, about 10 mg/mL to about 50 mg/mL, about ...
A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. The compositions are suitable for capturing unwanted molecules from inanimate surfaces, including fabrics, including carpets, and household surfaces such as countertops, dishes, floors, garbage cans, ceilings, walls, carpet padding, air filters, and the like, and from animate surfaces, including skin, hair, and the like. The compositions can further comprise cyclodextrin-compatible and -incompatible materials, and other optional ingredients.
A cyclodextrin-based chiral stationary phase (CD-CSP) is one of the most widely applied CSPs due to its powerful enantioseparation ability. In this study, a facile method was developed to prepare a CD-CSP via carboxyl methyl β-cyclodextrin (CD-COOH) and diazo-resin (DR). Monodisperse silica particles were sy
en] PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to ...
Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides). Cyclodextrins are produced from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering. α-Cyclodextrin is a soluble dietary fiber used as an ingredient in commercial food products. Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The largest cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape: α (alpha)-cyclodextrin: 6-membered sugar ring molecule β (beta)-cyclodextrin: 7-membered sugar ring molecule γ (gamma)-cyclodextrin: 8-membered ...
Inclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the pharmaceutical and chemical fields. For this study the inclusion of nine pharmaceutical drugs with CDs was investigated in the solid state. The objectives of the study were i.) the preparation, ii.) determination of the chemical composition, iii.) analysis of thermal behaviour and iv.) investigation of the solid state features of the complexes. Ultraviolet spectrophotometry, elemental analysis and thermogravimetric analysis were the principal techniques used for determination of composition. Hot stage microscopy, differential scanning calorimetry and thermogravimetric analysis were the principal techniques used for the analysis of thermal behaviour. Single crystal x-ray diffraction and x-ray powder ...
This study reports the formation of solid vanillin/cyclodextrin inclusion complexes (vanillin/CD ICs) with the aim to enhance the thermal stability and sustained release of vanillin by inclusion complexation. The solid vanillin/CD ICs with three types of CDs (α-CD, β-CD, and γ-CD) were prepared using the freeze-drying method; in addition, a coprecipitation method was also used in the case of γ-CD. The presence of vanillin in CD ICs was confirmed by FTIR and (1)H NMR studies. Moreover, (1)H NMR study elucidated that the complexation stoichiometry for both vanillin/β-CD IC and vanillin/γ-CD IC was a 1:1 molar ratio, whereas it was 0.625:1 for vanillin/α-CD IC. XRD studies have shown channel-type arrangement for CD molecules, and no diffraction peak for free vanillin was observed for vanillin/β-CD IC and vanillin/γ-CD IC, indicating that complete inclusion complexation was successfully achieved for these CD ICs. In the case of vanillin/α-CD IC, the sample was mostly amorphous and some uncomplexed
TY - JOUR. T1 - Thermodynamics of inclusion complex formation of β-cyclodextrin with a variety of surfactants differing in the nature of headgroup. AU - Benk, Mária. AU - Király, Zoltán. PY - 2012/11/1. Y1 - 2012/11/1. N2 - The inclusion complexation of β-cyclodextrin with various surfactants, possessing the same alkyl chain length but differing in the hydrophilic headgroup, was investigated by isothermal titration microcalorimetry. Sodium dodecyl sulfate, sodium dodecyl sulfonate, dodecyltrimethylammonium bromide and dodecyl(dimethyl)amine oxide were investigated. The major aim of this study was to elucidate the effects of temperature and the nature of the headgroup on the complex formation. Thermometric titrations were effected between the temperatures (288 and 348) K. The results provided the stoichiometry, the equilibrium constant and the reaction enthalpy of complexation. Changes in Gibbs energy, entropy and vant Hoff enthalpy were additionally calculated.. AB - The inclusion ...
1A47: Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
1A47: Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
0131]Pharmaceutical compositions of the present invention comprise a therapeutically effective amount of iron from one or more iron-containing compounds, and/or one or more compounds or agents selected from the group consisting of vitamin supplements, erythropoietin stimulating agents, erythropoietin, pharmaceutically acceptable carriers, transdermal permeabilizing agents, and cyclodextrins. As used herein and in the claims, the term cyclodextrin refers to any of a family of cyclic oligosaccharides. Cyclodextrins, also sometimes called cycloamyloses, are composed of, but are not necessarily limited to, five or more D-glucopyranoside units, connected by α-(1,4) glycosidic linkages, as in amylose. Cyclodextrins having as many as 32 1,4-glucopyranoside units have been well characterized. Cyclic oligosaccharides as large as 150 units have been identified. Typically, cyclodextrins contain, but are not necessarily limited to, six to eight glucopyranoside units in a ring, commonly termed ...
We report the effect of native cyclodextrins (alpha, beta, and gamma) and selected derivatives in modulating the self-assembly of the nonionic surfactant polyoxyethylene cholesteryl ether (ChEO(10)) and its mixtures with triethylene glycol monododecyl ether (C12EO3), which form wormlike micelles. Cyclodextrins (CDs) generally induce micellar breakup through a host-guest interaction with surfactants; instead, we show that a constructive effect, leading to gel formation, is obtained with specific CDs and that the widely invoked host-guest interaction may not be the only key to the association. When added to wormlike micelles of ChEO(10) and C12EO3, native beta-CD, 2-hydroxyethyl-beta-CD (HEBCD), and a sulfated sodium salt of beta-CD (SULFBCD) induce a substantial increase of the viscoelasticity, while methylated CDs rupture the micelles, leading to a loss of the viscosity, and the other CDs studied (native alpha- and gamma- and hydroxypropylated CDs) show a weak interaction. Most remarkably, the ...
Branched cyclodextrins are produced by the pyrolysis of cyclodextrins. The temperature range is 135 C. to 220 C. using equipment suitable for making British gum and other starch dextrins.
where [P]0 denotes the initial concentration of IBU and [CD]0 denotes that of CDs. F and F0 are the fluorescence intensities of IBU in the presence and absence of CDs, respectively. K is a formation constant, k is the instrument constant and Q is the fluorescence quantum yield of the inclusion complex. If the curve of 1/(F-F0) versus 1/[CD]0 exhibits good linearity, it implies that inclusion complexes with a stoichiometry of 1:1 are formed. B. Effect of the types of CDs β-CDs have the hydrophilic outer surface and a hydrophobic internal cavity. The inclusion interaction of β-CDs and the guest molecules is affected by the size of the internal cavity and hydrophilic, hydrophobic characters of the host. It is generally believed that dipole-dipole, electrostatic, van der Walls forces, hydrogen bonding, hydrophobic interaction, and the release of distortion energy of CD ring upon guest binding cooperatively govern the stability of an inclusion complex. The effect of HP-β-CD concentration on the ...
The preparation and characterization of a supramolecular host-guest inclusion complex between a fluorescent indolizinyl-pyridinium salt and β-cyclodextrin is reported. The formation of the inclusion complex was investigated by ESI-MS experiments, transmission electron microscopy, Jobs plot investigations an
Equilibrium constants and standard enthalpies have been measured calorimetrically for the formation of complexes of α-and β-cyclodextrins with substituted phenols in aqueous solutions at 298.15 K. The study includes variation of the size and shape of the phenol, the size and degree of methylation of the cyclodextrin, and the effects of pH and ionic strength. Substituent effects were measured for p-chloro-, p-bromo-, p-methyl-, p-hydroxy-, p-nitro- and m-nitrophenols. The effects of ionization were studied with m- and p-nitrophenolate ions. The effects of methyl substitutions of β-cyclodextrin were investigated with nitrophenol and nitrophenolate ions complexing with heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin. All of the effects studied show a substantial amount of entropic-enthalpic compensation, such that free energy effects are relatively small in comparison to enthalpic and/or entropie effects, but there was no simple relationship between the
The interactions of trimethoprim, sulphadiazine and sulphamethoxazole with natural (alpha-, beta-, gamma-) and amorphous (RAMEB) or crystalline (DIMEB) methylated beta-cyclodextrins were investigated both in aqueous solution (using phase-solubility analysis) and in the solid state (using DSC supported by X-ray analysis). In particular, DSC studies enabled determination of the relative degree of crystallinity of each drug in its physical and ground mixtures with the different cyclodextrins on the basis of the variation of its heat of fusion in comparison with that of the pure drug. In all cases, the host cavity size was a prevalent factor for the inclusion complexation in liquid state. On the contrary, it had a negligible effect on solid-state interactions in terms of drug amorphization. DIMEB and RAMEB exhibited similar performances in aqueous solution, showing that the presence of methyl-groups improved the complexing and solubilizing properties of beta-cyclodextrin. However, DSC studies ...
Maniruzzaman, Mohammed, Ross, Steven A., Dey, Tumpa, Nair, Arun, Snowden, Martin J. and Douroumis, Dennis (2017) A quality by design (QbD) twin-screw extrusion wet granulation approach for processing water insoluble drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 496-505. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2017.05.020) Snowden, Martin J. (2016) Colloidal microgels - untapped potential? Journal of Nanomedicine and Nanotechnology, 7 (4). pp. 1-2. ISSN 2157-7439 (Online) (doi:10.4172/2157-7439.1000e142) Rudrangi, Shashi Ravi Suman, Kaialy, Waseem, Ghori, Muhammad U., Trivedi, Vivek, Alexander, Bruce David and Snowden, Martin J. (2016) Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process. European Journal of Pharmaceutics and Biopharmaceutics, 104. pp. 164-170. ISSN 0939-6411 (doi:10.1016/j.ejpb.2016.04.024) Ehiwe, Tracy O., Alexander, Bruce D, Mitchell, John C., Snowden, Martin J. and ...
TY - GEN. T1 - Branching of cyclodextrins with various mono-, di-, and tri-saccharides by Bacillus acidophilus pullulanase.. AU - Madsen, U.. AU - Larsen, Kim Lambertsen. PY - 2002. Y1 - 2002. KW - Bioteknologi. KW - Bioteknologi. M3 - Article in proceeding. BT - Third Nordic Starch network Symposium. PB - Denmark.. ER - ...
Cyclodextrins: Roquette offers a wide range of betacyclodextrins KLEPTOSE® with different characteristics, solubility, water content, compactibility. | Roquette
From the kinetic investigation of the cleavage of the 4-acetoxybenzoate anion (4-ABA) in the presence of three cyclodextrins (Ì-CD, Ý-CD, and Þ-CD) in basic aqueous solution, the results indicate that 4-ABA binds to Ì-CD fairly weakly while no binding is observed between 4-ABA and Ý-CD or Þ-CD. The effects of the three CDs on the kinetics of the aminolysis of 4-ABA by primary amines have been investigated. Rate constants for the nucleophilic attack by free and CD-bound amine are obtained. For Ì-CD, values of the reactivity ratios for the linear amines are low (,1) implying deceleration of the aminolysis reaction due to binding to the CD. In the case of Ý-CD, the reactivity ratios are slightly larger (,1 for both n -alkyl and branched amines), implying modest catalysis. As for Þ-CD, the values of the reactivity ratios are ,2, which also signifies modest catalysis ...
Zhiyuan Biological is one of the leading China cyclodextrin complexes manufacturers and suppliers, as a professional company, we have productive factory, which is able to produce high-quality cyclodextrin complexes at good price. Welcome to buy products from us.
Energy-efficient physical separation on an industrial scale relies on controlling the porosity and thickness of the selective layer. The separation performance depends on the size, distribution, and connectivity of the voids, or free volume, within the membrane. Maximizing the amount of interconnected voids is crucial, but challenging. Amorphous polymers as membrane materials are not only economical but offer a variety of cavity sizes and topologies, in contrast to rigid microporous materials such as zeolites and metal-organic frameworks.. For the first time, a membrane composed exclusively of cyclodextrin is described by Tiefan Huang, Luis Francisco Villalobos, Klaus-Viktor Peinemann, and co-workers from King Abdullah University of Science and Technology in Saudi Arabia. Cyclodextrin-based polymers are appealing because cyclodextrin is intrinsically porous, non-toxic, and derived from starch, making the process environmentally friendly.. The team used β-cyclodextrin and an acid chloride to ...
The photochem. behavior of alkyldeoxybenzoins $PhCOCHPhCH_2CH_2R$ (R = H, Me, Et, hexyl, decyl) has been investigated in isotropic org. solvents, in aq. cyclodextrin solns., and bound to cyclodextrin in the solid state. Norrish type I and type II reactions occur in these media and the product distribution resulting from these primary processes are dependent on the medium. In org. solvents, type I and type II products are obtained in equal amts. In aq. cyclodextrin soln., type II products are formed in large excess. In the solid state, type II products constitute more than 90% of the product distribution. Ratios of products resulting from elimination and cyclization from the type II 1,4-diradical are also altered by the host cyclodextrin. Conformational and super-cage effects have been invoked to rationalize the dramatic alteration of the photobehavior of alkyldeoxybenzoins by cyclodextrin.. ...
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Together with an external partner, Harrison and his team are working on establishing cyclodextrins as a component of functional coatings and thus on rendering them useful to the construction industry. The idea is to incorporate the molecular safes, along with an insect-repelling essential oil, into wall paints that are not exposed to driving rain. Atmospheric moisture then determines how much of the fragrance is emitted to the ambient air. The more water molecules that are present in the atmosphere, the more fragrance is released. The cyclodextrins function like a reservoir, enabling the repellent to combat the pests continuously over a protracted period of time. Tests have confirmed that a commercial emulsion paint to which has been added a 5% complex of cyclodextrin and 0.5% citronella oil obtained from lemongrass, had a repellent effect on ants, for example. The protective and release mechanism works so well that the coatings functionalized with cyclodextrins can release the fragrance for up ...
The effect of cyclodextrin complexation on the solubility and photostability of nerolidol as pure compound and as main constituent of cabreuva essential oil
Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol while the ones constituting of hydroxypropyl-beta-cyclodextrin (HP-?-CD) did not show any such interference. Therefore, the present study is concentrated on exploring HP-?-CD as complexing agent. Phase solubility studies showed that complexation of Paracetamol/HP-?-CD at molar ratio 1:1 and showed AL type solubility curve. Complexation was done by various methods like physical mixing, kneading and freeze drying and resulting drug complexes were characterized by Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). The thermograms obtained showed an endothermic peak for
United This invention relates to complexes, or inclusion compounds, to the preparation of the same, and to edible materials incorporating them. A major problem in the production of convenience foods lies in the difficulty of retaining in the food certain flavors and/or aromas, which, although they may be present in minor amounts, are none the less important. In fact, capturing and preserving for subsequent use the fresh delightful flavors and aromas of fresh edible juices, such as those of freshly picked fruits, leaves and vegetables, is virtually impossible with present-day commercial techniques. Dried leaves, blanched and frozen leaves, dehydrated and frozen fruits and fruit juices, and the like, have been and are used as substitutes, but they fall considerably short of providing the true freshness of the untreated natural material. These flavors and aromas, or notes, which are characteristic of many fresh foods, tend to escape, or undergo change, or be lost in some way, before the food is ...
The synthesis of a new family of cyclodextrin (CD) analogues is described, This family consists of novel cyclic oligosaccharides built from monosaccharides that possess the same relative but opposite absolute (D- and L-) configurations. The alternation of such D- and L-residues-specifically, D- and L-rhamnose or D- and L-mannose-in a macrocyclic structure results in S-n-type symmetry and, consequently, optical inactivity. The synthesis of these cyclic oligosaccharides was achieved by an economical polycondensation/cycloglycosylation approach that relies on an appropriately-derivatized disaccharide monomer and that avoids the time-consuming, and often low-yielding, stepwise growth of long linear oligosaccharide precursors. In the cases reported, the key precursors are the disaccharide monomers 1-RR and 1-MM, which bear both a glycosyl donor (cyanoethylidene function) and a glycosyl acceptor (trityloxy group). These compounds are able to undergo Tr+-catalyzed polycondensation which, under ...
Cardiovascular disease resulting from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are candidate triggers early in the development of the disease.. Scientists from Bonn in Germany together with scientists from Center of Molecular Inflammation Research (CEMIR) in Trondheim and UiO/OUS Rikshospitalet in Oslo, have in a multi-international collaboration published in Science Translational Medicine that cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin dissolve cholesterol crystals and reduces atherosclerotic plaques. This is a promising therapeutic approach for treating atherosclerosis.. Cyclodextrin reprograms the macrophages in an anti-inflammatory manner in addition to increasing cholesterol efflux. The result is prevention of plaque formation and even atherosclerotic plaque regression in mice. Furthermore, biopsies of plaque carotid from humans treated with cyclodextrin showed similar ...
article{0f55d48c-6744-4fed-8c52-9bc57e9a4281, abstract = {The thickening effect of a hydrophobically modified polymer in an aqueous solution is dependent on intermolecular hydrophobic associations, and if the polymer concentration is significantly above the overlap concentration also on chain entanglements. In this investigation we have added different cyclodextrins (CD) in order to decouple hydrophobic polymer-polymer associations via inclusion complex formation with the polymer hydrophobic tails. Both size and hydrophobicity of the cavity of the CD-molecules were found to have an effect on the process. In addition, the influence of chemical structure of the polymer hydrophobic tails was investigated. Either a linear C-14-chain or a more bulky nonylphenol group was used. The viscosity as a function of CD-concentration first decreased strongly, and then attained a constant value. At excess CD the viscosity became virtually the same as in a solution of the unmodified parent polymer, provided that ...
The dielectric properties of alpha and beta cyclodextrin have been investigated in aqueous solutions. Static dielectric constants were measured in water and in mixtures of methyl sulfoxide-water and methanol-water at 25(DEGREES)C. Dielectric constants and losses were measured for water solutions onl.... Full description. ...
Cyclodextrin News, cyclodextrin, dimethyl-beta-cyclodextrin, cholesterol, conversion, biotransformation, solubility, vaccine product inhibition Bortadella
Novel multifunctional cyclodextrin-based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks ...
5 Nov 2010 2009; 395 125-133; 68 Sun B, Wu S, Li L, Li H, Zhang Q, Chen H, Li F, a beta- cyclodextrin-based formulation on tumor-bearing rats by a fully. ...
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TY - JOUR. T1 - Thermodynamic study of the discrimination between uridine and thymidine derivatives by hydrophobic, stacking, and intercalating interactions. AU - Rekharsky, M. V.. AU - Nakamura, Asao. AU - Hembury, G. A.. AU - Inoue, Y.. PY - 2001/3. Y1 - 2001/3. N2 - Thermodynamic parameters for the complexation reactions of uridine/thymidine nucleobases and related compounds, with hosts of differing binding modes and properties (natural cyclodextrins, 5,10,15,20-tetrakis (1-methlpyridinium-4-yl) porphyrin tetrachloride and bis-intercaland macrocycle) have been determined by titration microcalorimetry and/or fluorometry, in an aqueous buffer. For each of these hosts the effect of the 5-methyl group on the binding affinities was investigated. Although the affinities of uridine and thymidine towards cyclodextrins and 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetrachloride are very similar, the intercalation of these compounds into the bis-intercaland macrocycle has been shown to ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Darunavir, a protease inhibitor most widely used in the treatment of HIV infection, was complexed with β-cyclodextrin due to the low solubility in water and its poor bioavailability. This research describes the study the long-term stability of the complex darunavir: β-cyclodextrin which was kept in a climatic chamber for 24 months at 30°C ± 2°C and 75 % UR ± 5 %. The samples were analyzed using LC-MS, 250 mm × 4.6 mm CN Luna column, water + 0.1 % glacial acetic acid: acetonitrile + 0.1 % glacial acetic acid 60:40 (v/v) as mobile phase, flow rate of 1.0 mL min-1, UV detection at 268 nm and ambient room temperature (25°C) before the start of study and thereafter 3, 6, 9, 12, 18 and 24 months. The data obtained associated with the infrared, TG, DSC and X-ray diffraction analysis was sufficient to study the behavior of complex darunavir: β-cyclodextrin. The results of this research indicate that the stability of the complex darunavir: β-cyclodextrin is high under conditions associated of
Publication Details (including relevant citation information): Nociari, M.M., Lehmann, G.L., Perez Bay, A.E., Radu, R.A., Jiang, Z., Goicochea,
The purpose of this study was to develop and evaluate a solid nonaqueous oral dosage form for a new hepatitis C drug, PG301029, which is insoluble and unstable in water. Hydroxypropyl-β-cyclodextrin...
Protein aggregation is the major challenge encountered during manufacturing, storage and transportation of biopharmaceuticals (1,2). The objective was to evaluate the effect of two ßcyclodextrins derivatives: (KLEPTOSE® HPB hydroxypropyl-ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab and Etanercept) aggregation using high-throughput formulation screening (iFormulate™) and nanoDSF (Differential Scanning Fluorimetry) (3,4). Preliminary results demonstrate that KLEPTOSE® HPB BioPharma hydroxypropyl-ß-cyclodextrin and KLEPTOSE® HP BioPharma hydroxypropyl-ß-cyclodextrin at high molarity (200 mM) are efficient tools in modulating Infliximab…. ...
     Natamycin is an antimycotic with very low water solubility and extremely high photosensitivity, which is used to extend the shelf life of shredded cheese products. The objectives of this research are: (a) to find a new delivery system for natamycin, which increases its aqueous solubility and (b) to increase the chemical stability of natamycin so that it has a prolonged antifungal effect on the surface of the shredded cheese..      Molecular inclusion complexes of natamycin were formed with b-, hydroxypropyl b-, and g-cyclodextrins (CDs) which allowed large increases in aqueous solubility without the use of organic co-solvents or surfactants. The water solubility of natamycin was increased 16-fold, 73-fold, and 152-fold with b-CD, g-CD, and hydroxypropyl b-CD, respectively. The natamycin:CD inclusion complexes resulted in nearly equivalent in vitro antifungal activity as natamycin in its free state. Nuclear magnetic resonance (NMR) was utilized to prove the formation of ...
Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of enantiomers. In this mode, one or more chiral selectors are added to the background electrolyte acting as pseudostationary phases. Within the various chiral selectors that have been applied to enantioseparations in capillary electrokinetic chromatography, cyclodextrins are by far the most often used selectors because of their versatility, structural variety and commercial availability. This is reflected in the large number of applications of cyclodextrins to analytical enantioseparations that have been reported between January 2012 and July 2016, the period of time covered by this review. Many of these applications cover aspects of life sciences such as drug analysis, bioanalysis or food analysis. Despite the large number of commercially available cyclodextrins, new derivatives have been developed in order to achieve altered enantioselectivities or ...
TY - JOUR. T1 - Glucosylation of sucrose laurate with cyclodextrin glucanotransferase. AU - Okada, Katsuhide. AU - Zhao, Haisuo. AU - Izumi, Minoru. AU - Nakajima, Shuhei. AU - Baba, Naomichi. PY - 2007. Y1 - 2007. N2 - Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester.. AB - Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester.. KW - CGTase. KW - Cyclodextrin glucanotransferase. KW - Sucrose monolaurate. KW - Surfactant. UR - http://www.scopus.com/inward/record.url?scp=33947580881&partnerID=8YFLogxK. UR - ...
Cyclodextrin-mediated enantioseparation of phenylalanine amide derivatives and amino alcohols by capillary electrophoresis-Role of complexation constants and complex mobilities ...
AIM: Caffeic acid has been described as active against bacteria commonly isolated from wound infections. However, its low stability and poor solubility reduce caffeic acid applicability as a pharmaceutical product. These parameters can be enhanced by complexation with cyclodextrin. The main goal of the present work was to incorporate caffeic acid on cyclodextrin-based hydrogels capable of controlled delivery, in order to be used as antibacterial wound dressing. MATERIALS & METHODS: Cyclodextrin-based hydrogels were prepared by direct crosslinking of -cyclodextrin or hydroxypropyl--cyclodextrin with 1,4-butanediol diglycidyl ether in the presence of hydroxypropyl methylcellulose. RESULTS: The hydrogels obtained combine good physicochemical properties (viscoelasticity, superabsorbency and high ability to retain and deliver caffeic acid) with the preservation of caffeic acid antibacterial activity and effect on fibroblasts, with gel--cyclodextrin the most suited. CONCLUSION: The hydrogels obtained ...
Meclizine HCl is a poorly water-soluble drug having a very slow-onset of action. The effect of 2-hydroxypropyl-β-cyclodextrins and β-cyclodextrins on its aqueous solubility and dissolution rate was investigated. The phase solubility profile indicated that the solubility of Meclizine HCl was significantly increased in the presence of both 2-hydroxypropyl-β-cyclodextrin and β- cyclodextrin; an extend of increase being more for 2-hydroxypropyl-β-cyclodextrin. It was classified as AL -type, indicating the 1:1 stoichiometric inclusion complexes. The complexes formed were quite stable. The solid complexes prepared by physical mixtures, kneading methods, and co-precipitation methods were characterized using differential scanning calorimetry and FTIR. An in vitro study showed that the solubility and dissolution rate of Meclizine HCl were significantly improved by complexation with 2-hydroxypropyl-β-cyclodextrin. Tablet formulation using 1:1 kneading complex of Meclizine HCl and ...
Transformation of mechanically interlocked molecules (e.g., rotaxanes and catenanes) into nanoscale materials or devices is an important step towards their real applications. In our current work, an azobenzene-modified β-cyclodextrin (β-CD) derivative that can form a self-inclusion complex in aqueous solution was prepared. The self-included β-CD derivative was then functionalized onto a gold nanoparticle (AuNP) surface via a ligand-exchange reaction in aqueous solution, leading to the formation of AuNP-[1]rotaxane hybrids. Corresponding non-self-included β-CD derivative functionalized AuNPs were also developed in a DMF/H2O mixture solution for control experiments. These hybrids were fully characterized by UV-vis and circular dichroism spectroscopies, together with transmission electron microscopy (TEM). The competitive binding behavior of the hybrids with an adamantane dimer was investigated.
Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.
Purpose: Lipofuscin bisretinoids (LBs) accumulate irreversibly in the lysosomes of Retinal Pigment Epithelium (RPE) cells with age and in some genetic diseases, such as Stargardt and Best diseases. Excessive LB accumulation is toxic and causes retinal degeneration. The goal of this study is to develop a small drug to reduce the levels of LBs from RPE.. Methods: Using a novel solvatochromic fluorescence shift screening assay, we just developed, we searched for small molecules with ability to bind the most abundant LB, A2E.. Results: We have identified beta cyclodextrins (β-CDs), cyclic rings formed by 7 glucose residues, as small drugs that bind A2E. We show that treatment with beta-CDs stabilizes A2E by preventing its oxidation, and reduces bisretinoid content from lipofuscin granules in RPE. Molecular modeling of the complex indicate strategies to improve the LB binding of CDs. Furthermore, we tested the removal properties of CDs in eyes of ABCA4/RDH8 DKO animals, a mouse model for LB-driven ...
Cyclodextrin complex is suspended in polyalkylene glycol carrier material that does not displace the included material. The preferred perfume/cyclodextrin complexes, either alone or admixed with solvent (e.g., water), are preferably suspended in the carrier and then incorporated into solid, dryer-activated, fabric treatment (conditioning) compositions, preferably containing fabric softeners, more preferably cationic and/or nonionic fabric softeners. The perfume complexes provide fabrics with perfume benefits when they are rewetted after drying. Volatile perfume materials, including those materials that are commonly associated with freshness can be applied to the fabrics in an effective way.
In the present work the inclusion complexation of three sulfonamide (SA) drugs, namely sulfisoxazole (SSX), sulfamethizole (SMZ), and Sulfamethazine (STM) with ?-cyclodextrin (?-CD) has been investigated using UV-Vis spectroscopy, DSC, 1H NMR spectroscopy, and molecular modeling methods. The binding constant (Kb) of SA:?-CD inclusion complexation was determined via applying the modified form of Benesi-Hildebrand equation employing the changes in absorbance at ?max. Obtained results revealed that SA drugs form 1:1 inclusion complex with ?-CD with Kb of 650, 1532, 714 M-1 at 25 �C for SSX, SMZ, and STM, respectively. The UV-Vis absorption spectra displayed solvatochromic behavior of bathochromic shift with decreasing solvent polarity that in turn is good agreement with their behavior in the presence of ?-CD in terms of environment polarity dependency. The inclusion complex formation between ?-CD and tested SA drugs in liquid and solid states was confirmed by 1H NMR and DSC, respectively. Using ...
TY - JOUR. T1 - Meta/para-selectivity variation by sulfide/sulfoxide conversion of 6-substituted β-cyclodextrin. Hydrolyses of nitrophenyl acetates. ag. AU - Fujita, Kahee. AU - Ejima, Seiji. AU - Ueda, Tadashi. AU - Imoto, Taiji. AU - Schulten, Hans Rolf. PY - 1984. Y1 - 1984. N2 - Hydrolyses of m- and p-nitrophenyl acetates by 6-deoxy-6-alkylthio-β-cyclodextrins and the corresponding sulfoxides were studied to show that the small chemical conversion from the sulfides to the sulfoxides led to a change of meta/para-selectivity in the hydrolysis of the β-cyclodextrin moiety.. AB - Hydrolyses of m- and p-nitrophenyl acetates by 6-deoxy-6-alkylthio-β-cyclodextrins and the corresponding sulfoxides were studied to show that the small chemical conversion from the sulfides to the sulfoxides led to a change of meta/para-selectivity in the hydrolysis of the β-cyclodextrin moiety.. UR - http://www.scopus.com/inward/record.url?scp=6544223514&partnerID=8YFLogxK. UR - ...
Cyclodextrin glycosyltransferase (CGTase) catalyzes the conversion of starch into non-reducing cyclic sugars, cyclodextrins, which have several industrial applications. This study aimed to establish optimal culture conditions for β-CGTase production by Bacillus sp. SM-02, isolated from soil of cassava industries waste water lake. The optimization was performed by Central Composite Design (CCD) 2, using cassava flour and corn steep liquor as substrates. The maximum production of 1087.9 U mL−1 was obtained with 25.0 g L−1 of cassava flour and 3.5 g L−1 of corn steep after 72 h by submerged fermentation. The enzyme showed optimum activity at pH 5.0 and temperature 55 °C, and maintained thermal stability at 55 °C for 3 h. The enzymatic activity was stimulated in the presence of Mg+2, Ca+2, EDTA, K+, Ba+2 and Na+ and inhibited in the presence of Hg+2, Cu+2, Fe+2 and Zn+2. The results showed that Bacillus sp. SM-02 have good potential for β-CGTase production.
A suitable host-guest inclusion complex has beenmade with a guest molecule, 1-methyl-3- octylimidazolium chloride ([MOIm]Cl) and a host molecule, α-cyclodextrin in aqueous medium. Formation of the host-guest inclusion complex has been established by Surface tension and conductivity readings while1H NMR and ultraviolet spectroscopy readingconfirms1:1 host-guest stoichiometry. These results have implications for the formation of host-guest inclusion complex of studied ionic liquid as guest in aqueous α-cyclodextrin media.. ...
A multiple regression model was generated, which can satisfactorily estimate the association constants (K-a) for the inclusion complexation of beta-cyclodextrin with mono- and 1,4-disubstituted benzenes. It was found that lnK(a) was correlated with the substituent molar refraction (R-m), hydrophobic constant (pi) and Hammett constant sigma) of the guest compounds with a correlation coefficient of 0.95. The main driving forces for beta-cyclodextrin complexation was concluded to consist of van der Waals forces and hydrophobic interactions, while the influence of electronic effects was small.; A multiple regression model was generated, which can satisfactorily estimate the association constants (K-a) for the inclusion complexation of beta-cyclodextrin with mono- and 1,4-disubstituted benzenes. It was found that lnK(a) was correlated with the substituent molar refraction (R-m), hydrophobic constant (pi) and Hammett constant sigma) of the guest compounds with a correlation coefficient of 0.95. The ...
Search and download thousands of Swedish university dissertations (essays). Full text. Free. Dissertation: NMR Studies of Inclusion Compounds.
A new technique to produce very small magnetic nanoparticles of maghemite (gamma-Fe(2)O(3)) is presented. The particles form and precipitate in the presence of the oligosaccharide gamma-cyclodextrin and in the final product remain entrapped in tiny pseudo-single crystals of the organic host. Evidence of nanosized particles embedded in the organic crystal was obtained by HR-TEM studies that showed the occurrence of uniformly dispersed particles with average diameter of 18 Angstrom. The resulting objects gave diffraction patterns with the same spacing as that of cyclodextrin crystals without iron. The magnetic properties were investigated by ZFC-FC magnetizations, hysteresis loops, and ac susceptibility measurements. The compound presents a complex magnetic behavior that deviates from that predicted on the basis of the classic single domain particle model. The deviation is ascribed to the complex properties of the surface, which, for such small sizes, plays the major role in determining the total ...
Communications Enantiomer Separation Modified Linear Dextrins (Acyclodextrins) as New Chiral Selectors for the GasChromatographic Separation of Enantiomers** Giuseppe Sicoli, Zhengjin Jiang, Laszlo Jicsinsky, and Volker Schurig* In memory of Jzsef Szejtli Cyclodextrins (CDs) modified by alkylation, acylation, and silylation represent versatile chiral stationary phases (CSPs) for the gas-chromatographic separation of enantiomers.[1] Typically, they are dissolved in semipolar polysiloxanes[2a] or linked chemically to polydimethylsiloxane (Chirasil-Dex).[2b] The mechanism of enantiomer recognition is still not well understood, and the role of the CD cavity is unclear in cases were enantioselectivity is low, as it is in most reported cases (a , 1.1).[1a] We therefore conjectured that the existence of a cavity may not be a prerequisite to chirality recognition in cyclodextrins. This has now been borne out by employing linear dextrins (acyclodextrins) as a new generation of carbohydrate-based ...
The NNPDF central office received a press release from the National Institute of Health (NIH) NPC Clinic from Dr. Forbes Denny Porter with an update on the Cyclodextrin Trial ...
Glucose oxidase (GOx) and horseradish peroxidase (HRP) are important enzymes for the development of amperometric enzyme linked immunosensors. The selectivity of each enzyme towards its analyte deepens its importance in determining the sensitivity of the resultant immunosensor. In designing immunosensors that have customized transducer surfaces, the incorporation with FAD and iron based enzymes ensures that electron kinetics remains optimal for electrochemical measurement. Various different immobilization strategies are used to produce response signals directly proportional to the concentration of analyte with minimal interferences. The combination of self-assembled monolayers and supramolecular chemistry affords stability and simplicity in immunosensor design. In this work, two electrochemical strategies for the detection of human chorionic gonadotropin(hCG) is presented. This involves the modification of a gold surface with a thiolated β-cyclodextrin epichlorohydrin polymer (βCDPSH) to form a ...
When during the companys R&D day the CEO of Alnylam, John Maraganore, highlighted Calandos cyclodextrin-based siRNA delivery technology (RONDEL) as one of the noteworthy non-SNALP systemic siRNA delivery technologies out there, it certainly piqued my interest. This is not least because any cash infusion and longer-term commitment by a partner like Alnylam would do wonders for the parent company of Calando, Arrowhead Research which is a conglomerate of early-stage, IP-focused business units and has just barely scraped by bankruptcy through a diet of cutbacks. While I always remembered the maturity of RONDEL, developed in the Mark Davis lab at Caltech, to be years behind SNALP, Tobias and I decided to to take a closer look at the development path of CALAA-01, the first clinical RONDEL delivery candidate and also investment focus of reorganized Arrowhead Research. When Tobias first heard of the technology, it struck him as a very elegant, because simple, and modular method to formulate targeted ...
Atherosclerosis is the primary process at the rear of cardiovascular illnesses (CVD), maladies which continue being in charge of up to 70% of loss of life worldwide. family members. The curcuminoids comprise many compounds, such as for example curcumin, bis-demethoxy-curcumin and desmethoxycurcumin. The foundation CD14 of curcumin is normally turmeric, a yellow-colored spice [45]. Pharmacokinetic studies revealed that curcumin is normally soluble in water poorly; provides low absorption in the gut, speedy fat burning capacity and systemic reduction, and consequently, provides low PXD101 ic50 bioavailability after dental administration. The scientific efficiency of curcumin could possibly be improved by formulations that enhance its solubility and balance and diminish the first-pass fat burning capacity. To that final end, specific strategies have already been elaborated, like the advancement of curcuminCpiperine complexes, curcumin nanoparticles, cyclodextrin inclusions, curcumin curcumin and ...
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications. ...
TY - JOUR. T1 - Osmium-labeled polysaccharides for atomic microscopy. AU - Resch, James. AU - Tunkel, David E. AU - Stoeckert, Christian. AU - Beer, Michael. PY - 1980/4/25. Y1 - 1980/4/25. N2 - With the objective of localizing cell surface polysaccharides, the reaction of several osmium (VI)-ligand complexes with glycols has been applied to sugar residues in mono- and polysaccharides. The hydrophilic ligands 4,4′-dicarboxy-2,2′-bipyridine and N,N,N′,N′-tetramethylethylenediamine have been employed to produce water-soluble osmate esters of the sugar glycols. Methyl glycosides react with osmium (VI) reagents to give stable products containing one osmium atom per sugar. α-Cyclodextrins, with six glucose residues in a ring, and β-cyclodextrins with seven, can bind up to, but not exceeding three osmium ligand complexes per molecule, indicating possible nearest-neighbor exclusion of reaction among the residues. Reaction of as little as 1% of the sugar residues in amylose with the ...
Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are characterized by their flawlessness and lose their value due to micro-scratches. A new paint from Saarbrücken researchers now could provide a solution: Due to the special arrangement of its molecules, maize starch based coating is able to repair small scratches by itself through moderate heat treatment. The cross-linking via ring-shaped molecules makes the material flexible, so that it compensates for the scratches and they disappear again. The new coating was developed by INM experts together with scientists from Saarland University.. The developers will be presenting the coating with a live demonstration at this years Hannover Messe from 1 to 5 April at Stand C54 in Hall 5.. The scientists used ring-shaped derivatives of corn starch, so-called cyclodextrins, for the network structure of the lacquers. These cyclodextrins were threaded like ...
Alibaba.com offers 5,826 beta-cyclodextrin products. About 48% of these are auxiliaries and other medicinal chemicals, 26% are animal pharmaceuticals, and 12% are vitamins, amino acids and coenzymes. A wide variety of beta-cyclodextrin options are available to you, such as food grade, cosmetic grade, and tech grade.
The desired gamma-CD based carrier greatly reduced DOXs toxicity in vitro: up to 95% toxicity reduction in KB human enpidermal carcinoma; up to 92% toxicity reduction in HCT116 colorectal carcinomar. Cellular DOX uptake was reduced 73% in muscle, 69% in kidney, 66% in liver, 65% in heart, 62% in brain, 53% in lungs as 25% in plasma in vivo. The carrier-DOX inclusion is highly stable under physiological temperature and pH as well as under a wide range of acidic conditions (pH 1.0~7.0); the encapsulated DOX is slowly released under hyperthermic conditions (up to 50°C). In the presence of MBs (0.1%, 1%, 2.5% and 5%) application of FUS with low mechanical indexes (0.24, 0.31 and 0.53), under which no thermal effect was observed, enhanced up to 3.89-fold of cellular drug uptake for encapsulated DOX in vitro. Optimal setup of MR parameters: TR/TE = 3180/96.3msec; bandwidth: 10.4 kHz; Field of View = 20×20cm; matrix: 384×384, NEX: 2; slice thickness: 2.0mm/1.0sp; number of slices: 8; frequency ...
Omega-3 fatty acids (FAs) and their glycerides are important bioactive compounds that are found in fish oils and some vegetable oils. They are involved in human health, especially on brain and cardio-vascular diseases. The main disadvantages of these compounds are related to the low oxidative and thermal stability as well as very low water solubility. Natural cyclodextrins (α-, β- and γ-CD) can be appropriate matrices for enhancing their stability and apparent water solubility. In the present study the molecular modeling and conformational analysis on free omega-3 FAs (e.g. α-linolenic, all-(Z) eicosa-5,8,11,14,17-pentaenoic, and all-(Z) docosa-4,7,10,13,16,19-hexaenoic acids) and their mono-, di- and triglycerides have been performed using molecular mechanics (MM+) method in vacuum. The minimum energy conformations were used for docking in α-, β- and γ-CD at 1:1, 1:2 and 1:3 molecular ratios. The best FAs (or their glyceride) / CDs interactions were obtained for the hydrophobic moiety of ...
Omega-3 fatty acids (FAs) and their glycerides are important bioactive compounds that are found in fish oils and some vegetable oils. They are involved in human health, especially on brain and cardio-vascular diseases. The main disadvantages of these compounds are related to the low oxidative and thermal stability as well as very low water solubility. Natural cyclodextrins (α-, β- and γ-CD) can be appropriate matrices for enhancing their stability and apparent water solubility. In the present study the molecular modeling and conformational analysis on free omega-3 FAs (e.g. α-linolenic, all-(Z) eicosa-5,8,11,14,17-pentaenoic, and all-(Z) docosa-4,7,10,13,16,19-hexaenoic acids) and their mono-, di- and triglycerides have been performed using molecular mechanics (MM+) method in vacuum. The minimum energy conformations were used for docking in α-, β- and γ-CD at 1:1, 1:2 and 1:3 molecular ratios. The best FAs (or their glyceride) / CDs interactions were obtained for the hydrophobic moiety of ...
Abstract: Host-guest interactions of β-cyclodextrin (β-CD) with enantiomers of ethyl α-chloropropionates ((R/S)-ECPA) were simulated using the quantum mechanics PM3 method. The chiral recognition mechanism of (R/S)-ECPA enantiomers on β-CD was investigated. Modeling results showed that the stabilization of complexes formed by (R/S)-ECPA enantiomers and β-CD were different. (R)-ECPA was located on the cavity wide mouth end of β-CD to form an associated molecule, but (S)-ECPAinserted into the β-CDcavity to forman inclusion molecule. The stabilization energy of the (S)-ECPA and β-CD complex was lower than that of the (R)-ECPA and β-CD complex. The chiral carbon in the ECPA of (R/S)-ECPA and β-CD complexes was close to the C2 and C3 in the glucose unit. The chiral recognition mechanism was thus closely related to the chiral environment provided by C2 and C3 in the glucose unit and the degree of (R/S)-ECPA and β-CD inclusion.. Key words: PM3, Ethyl α-chloropropionate, β-Cyclodextrin, ...
Beta-cyclodextrin - Browse fuzing.com to find beta-cyclodextrin sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories.
Piroxicam-Beta-Cyclodextrin is made by enwrapping medical piroxicam and medical beta-cyclodextrin in a certain inverse proportion with a unique art. This inclusion compound has less odor, more stability and more stable medicine releasing speed than the si
The granular starch-binding function has been demonstrated in several cases. Interact strongly with cyclodextrins. Often designated as starch-binding domains (SBD ...
CAS No. 128446-35-5 Model Number SGONEK-beta cyclodextrin Purity 99% Appearance White Powder Grade Pharmaceutcial Grade Siez 100% Pass 80 Mesh Sample 1-5g free Test Method HPLC UV Package 1KG/Bag,5kg/bag,25kg/bag Certificate ISO/FDA/S G S/M
Antioxidants are health beneficial compounds that can protect cells from the damage caused by unstable molecules known as reactive oxygen species (ROS). This work reports the capacity assay of both lipophilic and hydrophilic antioxidants simultaneously, by making use of their host-guest complexes with methyl-beta-cyclodextrin (M-beta-CD), a cyclic oligosaccharide, in acetonated aqueous medium using the cupric reducing antioxidant capacity (CUPRAC) method. Thus the order of antioxidant potency of various compounds irrespective of their lipophilicity could be established in the same solvent medium. M-beta-CD was introduced as the water solubility enhancer for lipophilic antioxidants. Two percent M-beta-CD (w/v) in an acetone-H2O (9:1, v/v) mixture was found to sufficiently solubilize beta-carotene, lycopene, vitamin E, vitamin C, synthetic antioxidants and other phenolic antioxidants. This assay was validated through linearity, additivity, precision, and recovery. The validation results ...
Supramolecular systems, which are formed by the noncovalent intermolecular interactions between molecules, are highly dynamic. The high reversibility of supramolecular systems leads to some functional features that cannot be achieved by the single chemical component. The kinetic information for the supramolecular systems can not be inferred from thermodynamic studies or structural studies. Furthermore, the information provided by the dynamic study can be employed to infer or explain the results from the thermodynamic study and the structural study. The first objective of this work was to study the dynamics and the binding mechanism of cucurbit[7]uril with a charged guest molecule (2-naphthyl-1-ethylammonium cation, NpAmH+). In general, the binding affinity of cucurbit[7]uril to the positively charged guests are very high compared with other host systems such as cyclodextrins and bile salt aggregates. In this work, the complexation of cucurbit[7]uril and NpAmH+ was studied from a kinetic point of view.
Summary of Facts and Submissions. I. European patent No. 1 594 478 was granted on the basis of ten claims.. Independent claim 1 reads as follows:. 1. Tablets containing one or more active pharmaceutical, dietetic or nutritional ingredients comprising at least one inner layer of gum base and outer layers comprising antiadhesion excipients and compression adjuvants selected from Isomalt, Maltol, Maltodextrin, Maltitol, Mannitol, Xylitol, Lactitol, Lactose, Skim Milk, Eritritol, Oligofructose, Retrograded Starch, polysorbates, polyethyleneoxide, dextrans, Cyclodextrins, Oligosaccarose, fructose, hydrogenated starch hydrosilates, said tablets having a sandwich like structure, the external layers containing said antiadhesion excipients being not in contact one with the other and respectively coating only the upper and the bottom part of the gum core, leaving the peripheral side thereof uncoated.. Claims 2 to 8 are dependent on claim 1. Independent claim 9 is directed to a process for the ...
During the last years she studied non-covalent interaction of small molecules with hosts of different types. Non-covalent interactions driven by H-bonds, Van der Waals, electrostatic and hydrophobic forces are at the basis of a large number of phenomena of interest in chemistry, biology and material science. Understanding the factors that govern the intermolecular interactions is an important issue. First she looked at the interaction of small chromophoric molecules with different cyclodextrins as model carrier systems and next extended her interest to the study of the interaction of small molecules with human serum albumin, chosen as transport protein and model for other proteins. Recently she also dedicated to the binding of small molecules to DNA, in particular G-rich strands in quadruplex and duplex conformation. She mainly focused on already known photoactive drugs of different classes like NSAID (ketoprofen), antibiotics (quinolones), antitumorals (doxorubicin and sabarubicin) and ...
During the last years she studied non-covalent interaction of small molecules with hosts of different types. Non-covalent interactions driven by H-bonds, Van der Waals, electrostatic and hydrophobic forces are at the basis of a large number of phenomena of interest in chemistry, biology and material science. Understanding the factors that govern the intermolecular interactions is an important issue. First she looked at the interaction of small chromophoric molecules with different cyclodextrins as model carrier systems and next extended her interest to the study of the interaction of small molecules with human serum albumin, chosen as transport protein and model for other proteins. Recently she also dedicated to the binding of small molecules to DNA, in particular G-rich strands in quadruplex and duplex conformation. She mainly focused on already known photoactive drugs of different classes like NSAID (ketoprofen), antibiotics (quinolones), antitumorals (doxorubicin and sabarubicin) and ...
This May sees the next talk in the monthly Water Colloquium series organised by WIRC @ Bath exploring the breadth of water research being undertaken at the University of Bath and beyond.. Title: Linking chemical-soil interactions to pollutant fate and transport from soil to water. Speaker: Dr Brian J. Reid, Reader, School of Environmental Sciences, University of East Anglia. When: Thursday 18th May 2017 at 1.15pm. Where: Room 2.1, 6 East, University of Bath (Location and maps). Abstract: The seminar will begin by introducing the fundamentals of how chemical and physical phenomena underpin soil-pollutants interactions. From this perspective the implications of these interactions for pollutant bioavailability and transport will be developed. I will introduce seminal research relating to the application of cyclodextrins as bioavailability mimetics (and standardisation with the ISO). I will provide insights into the interplay between pollutant exposure, pollutant bioavailability and microbial ...
The group is working in two different areas. One area is focused on the use of boron clusters as new entities for drugs and in supramolecular chemistry. The clusters have unique properties which are not found in organic or other inorganic molecules. They are the first anions which bind strongly to supramolecular hosts such as cyclodextrins and cucurbiturils. Due to the unusual properties of the cluster, their interaction with biological membranes is unexpected. The necessary methods for synthesizing derivatives of these clusters are being pursued.. The other area deals with the development of new dyes for ocular surgery. The aim is to develop better dyes, especially for visualization of the internal limiting membrane. This work includes synthesis, testing for toxicity in vitro, staining in suitable models, and collaboration with ophthalmologists for eventual application in the clinic.. Boron clusters. ...
The skin regenerates itself throughout epidermis and dermis for thicker and elastic skin. This will help reduce wrinkles and lines. The skin becomes more elastic, fresh, and enriched.. Cold processed Retinol in cream formulations is stable for at least one year, and the shelf life can be extended with Chelating agents, light protected sealed packaging like glass or aluminum. Anhydrous compositions increase shelf life and potency and hence are even more preferable.. Retinol 50P (Pharmaceutical) is a 50% Retinol in Tween-20. Retinol 50C (Cosmetic) is a 50% Retinol in Tween-20. Stabilized with cyclodextrins, liposomes, and with other vitamins is not desirable since their bio-availability gets lowered.. Enhance A.C.E. Treatment is a Retinol booster that helps accelerate cell turnover quickly while making the skin more elastic and enriched. This Treatment can be combined with other treatment modalities to give a more effective anti-aging treatment. With the help of synergistic Vitamin C & E ...
We are look for reaction types that simultaneously: (1) provide for the reaction of acyl and phosphoryl groups under non-forcing conditions; (2) suggest ways for elaboration into catalytic cycles with turnover behavior; and, (3) survive translation onto binding moieties. To date, we have focussed on artificial metalloenzymes derived from Co(III) and Cu(II) coordination complexes with cyclodextrins, preassociating alpha-nucleophiles, and binuclear metal ion complexes.
The beneficial effects of the Mas/Ang-(1-7) pathway prompted us to develop novel Ang-(1-7) analogues and ligands for Mas. In the present study, we evaluated the cardiometabolic effects of a pharmacological formulation developed by including the Mas agonist A-1317 in hydroxypropyl β-cyclodextrin (HPβCD). The inclusion compound was given orally (10 μg/Kg body weight) to Spontaneously hypertensive rat (SHR) and fructose-fed rats. Mean arterial pressure (MAP) and heart rate (HR) were monitored for 5 hours after administration of a single dose of A-1317-HPβCD in conscious SHR. Seven-weeks-old male Sprague-Dawley rats were fed with either normal rat chow (CTL) or the same diet plus 10% fructose in the drinking water (FFR). For the last 4 wk of a 9-wk period of each diet, a subgroup of each group of animals was treated daily with the oral A-1317 (CTL-A or FFR-A) or with vehicle (CTL-V or FFR-V). Rats were subjected to oral glucose tolerance test (2 g/Kg body weight) concomitantly with the ...
The aim of this study was to enhance the aqueous solubility of celecoxib by complexation with cyclodextrin in the presence of water-soluble polymer.
... cyclodextrin". Journal of the American Chemical Society. 105 (5): 1390-91. doi:10.1021/ja00343a063. "Anthony W. Czarnik, Ph.D ...
in the presence of cyclodextrins". Enzyme and Microbial Technology. 11 (7): 398-404. doi:10.1016/0141-0229(89)90133-6. Sandow J ...
in the presence of cyclodextrins". Enzyme and Microbial Technology. 11 (7): 398-404. doi:10.1016/0141-0229(89)90133-6. "Dea ...
He also showed that cyclodextrin can be used to investigate catalysis of organic reactions within the scope of host-guest ... Bender, Myron L; Kobiyama, M. (1978). cyclodextrin chemistry. Berlin: Springer-Verlag. ISBN 978-3540085775.. ... and also cyclodextrin chemistry; The series of Myron L. Bender & Muriel S. Bender Distinguished Summer Lectures in Organic ...
Asim, MH; Ijaz, M; Rösch, AC; Bernkop-Schnürch, A (2020). "Thiolated cyclodextrins: New perspectives for old excipients". ...
α-cyclodextrins comprise six glucopyranose units, β- cyclodextrins comprise seven, and γ comprise eight. Cyclodextrins are ... To synthesize cyclodextrins, enzymatic action occurs on hydrolyzed starch. Cyclodextrin nanosponges are made of a three ... Trotta, Francesco (2011), "Cyclodextrin Nanosponges and their Applications", Cyclodextrins in Pharmaceutics, Cosmetics, and ... β-cyclodextrins are used due to low cost and medium-sized pores allowing for a broad range of guest molecules to be collected. ...
... dimethylformamide or dimethyl sulfoxide is able to interrupt the hydrogen bonding between cyclodextrins in the cyclodextrin- ... Cyclodextrins have been extensively studied as host molecules (ring) in polyrotaxanes. The poly(ethylene glycol)s can assemble ... Every two ethyleneoxy repeat units in poly(ethylene glycol)s can thread in one α-cyclodextrin. The models confirm that the ... This is because the hydrogen bonding between the cyclodextrins. As the hydrogen bonding is destroyed by dimethyl sulfoxide or ...
By combining ferrocene dimer with β-cyclodextrin dimer, a redox-control supramolecular polymers system has been proposed as a ... Akira Harada was one of the firstwhorecognize the importance of combining polymers and cyclodextrins. Feihe Huang showed an ... cyclodextrins/adamantane derivatives, and pillar arene/imidazolium derivatives [30-33]. When the monomers are "heteroditopic", ... "Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and alpha-cyclodextrin for ...
A few exceptions exist, such as certain cyclodextrins. For condensed phases (solids and liquids), the pressure dependence of ... Salvatore Filippone, Frank Heimanna and André Rassat (2002). "A highly water-soluble 2+1 b-cyclodextrin-fullerene conjugate". ...
Cyclodextrin The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of starch by certain ... bacteria, for example, Paenibacillus macerans (Bacillus macerans). Cyclodextrins have toroidal structures formed by 6-8 glucose ...
The cyclodextrins can absorb an estimated 60 percent of their own weight in alcohol. A US patent was registered for the process ... Nebulizer: Alcohol powder produced through molecular encapsulation with cyclodextrin can be used with a nebulizer though this ... "Aerosolization potential of cyclodextrins-influence of the operating conditions". PDA Journal of Pharmaceutical Science and ... alcohol can be absorbed in cyclodextrins, a synthetic carbohydrate derivative. In this way, encapsuled in small capsules, the ...
Here she proposed the use of the chiral additives sulphated-β-cyclodextrin, heparin and quinine in capillary electrophoresis. ... Stalcup, Apryll M.; Gahm, Kyung H. (1996). "Application of Sulfated Cyclodextrins to Chiral Separations by Capillary Zone ... Cyclodextrins: A Versatile Tool in Separation Science". ChemInform. 32 (2): no. doi:10.1002/chin.200102265. ISSN 0931-7597. ...
Clathrate Clathrochelate Cryptophane Cyclodextrin Alberto, R.; Ortner, K.; Wheatley, N.; Schibli, R.; Schubiger, A. P. (2001 ...
Other substituted β-cyclodextrins have since been reported, including thiol-modified cyclodextrins, an anion-selective ... Chui, J. K. W.; Fyles, T. M. (May 2010). "Apparent fractal distribution of open durations in cyclodextrin-based ion channels". ... The first synthetic ion channel was constructed by partial substitution on the primary rim of β-cyclodextrin. ... Structure-activity relationships for a large suite of cyclodextrin "half-channels" prepared by "click"-chemistry has been ...
Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature ...
... alpha-cyclodextrin glucanotransferase, alpha-cyclodextrin glycosyltransferase, beta-cyclodextrin glucanotransferase, beta- ... cyclodextrin glycosyltransferase, gamma-cyclodextrin glycosyltransferase, cyclodextrin glycosyltransferase, cyclomaltodextrin ... Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin ... The coupling reaction can be easily described as the reverse process of cyclization: the enzyme cleaves a cyclodextrin to ...
No covalent bonds are present between the cyclodextrins and the curcuminoids so they are easily released from the complex by ... The curcuminoids would be in complex with the core of the micelles similar to the complex inside the cyclodextrins. The ... Degradation rate is depended on pH of the solution and how much protection the cyclodextrins provide the curcuminoids. The ... Cyclodextrin complexation: solubility, chemical and photochemical stabilit". International Journal of Pharmaceutics. 244 (1-2 ...
"Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming". Science Translational Medicine. 8 (333): ... aspirin supplement oligosaccharide 2-hydroxypropyl-β-cyclodextrin can solubilize cholesterol, removing it from plaques[better ...
The sugar, cyclodextrin, removed cholesterol that had built up in the arteries of mice fed a high-fat diet. Aging is the most ... "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming". Science Translational Medicine. 8 (333): ...
Cyclodextrins are well established hosts for the formation of inclusion compounds.[1][2][3] Illustrative is the case of ... Cyclodextrin also forms inclusion compounds with fragrances. As a result, the fragrance molecules have a reduced vapor pressure ... Yu Liu, Rui-Qin Zhong, Heng-Yi Zhang and Hai-Bin Song (2010). "A unique tetramer of 4:5 -cyclodextrin-ferrocene in the solid ... L. (2005). "Fragrance-release Property of β-Cyclodextrin Inclusion Compounds and their Application in Aromatherapy". Journal of ...
It uses cyclodextrins, a chromophore, and a number of metal salts. This can either be seen directly or connected to an infrared ...
Chemically they are similar to the much smaller cyclodextrins, which are typically composed of 6, 7 or 8 glucose units. ... While the structures of cyclodextrins are planar circles, the structure of cycloamyloses with 10 to 14 glucose units were ... "Structures of the Common Cyclodextrins and Their Larger AnaloguesBeyond the Doughnut". Chemical Reviews. 98 (5): 1787-1802. doi ...
Bilensoy, Erem (2011). Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine : Current and Future Industrial Applications ...
Her research on cyclodextrins started soon after her methods focused on gas chromatography, high-performance liquid ... Her research became more widespread and she was asked to add many monographs on cyclodextrins, one of them being for a ... her first choice being cyclodextrins, but moving on with urea and thiourea for the separation of isomers. ... "Study of retention of isomeric aromatic hydrocarbons on GTCB and cyclodextrins". "Eva Smolková-Keulemansová (1927)". www. ...
"From algal polysaccharides to cyclodextrins to stabilize a urease inhibitor" (PDF). Carbohydrate Polymers. 112: 145-151. doi: ...
Derived from this the derivatization of β-cyclodextrin to sulfobutyl ether-beta-cyclodextrin (SBECD) is by now an important ... β-Cyclodextrin can be reacted with 1,4-butanesultone in sodium hydroxide solution at 70 °C to the sulfobutyl ether in yields of ... Thereby, the water solubility of the β-cyclodextrin increases from 18.5 g · l-1 to more than 900 g · l-1 at 25 °C. Sulfobutyl ... Sulfobutyl ether-beta-cyclodextrin is a water-soluble inclusion compound for the solubilization and stabilization of sparsely ...
"Energetics of cellulose and cyclodextrin glycosidic bond cleavage". Royal Society of Chemistry, Reaction Chemistry & ...
"Structures of the Common Cyclodextrins and Their Larger Analogues-Beyond the Doughnut". Chemical Reviews. 98 (5): 1787-1802. ...
Intense Phosphorescence Triggered by Alcohols upon Formation of a Cyclodextrin Ternary Complex. Ponce, A.; Wong, P. A.; Way, J ... Substrate Induced Phosphorescence from Cyclodextrin/Lumophore Host-Guest Complexes. Hartman, W.; Gray, M.; Ponce, A.; Wong, P. ...
The use of cyclodextrin as a sprayable odor absorber was patented by Procter & Gamble. The products include additional ... The active ingredient in several Febreze products is hydroxypropyl beta-cyclodextrin (HPβCD). The molecule traps and binds ... Uncomplexed cyclodextrin solutions for odor control on inanimate surfaces. US Pat. No. 5,714,137. Filed 1994; assigned 1998. ... Cyclodextrin". Procter&Gamble. 2005. *P&G. (2014). Febreze FAQ (in japanese). Retrieved: http://www.febreze.jp/Faq.aspx?id=4442 ...
GRN 000155, alpha-cyclodextrin;GRAS Notice No. GRN 000074, beta-cyclodextrin;GRAS Notice No. GRN 000046, gamma-cyclodextrin ... cyclodextrin: 7 glucose subunits γ (gamma)-cyclodextrin: 8 glucose subunits Cyclodextrins are ingredients in more than 30 ... Both β-cyclodextrin and methyl-β-cyclodextrin (MβCD) remove cholesterol from cultured cells. The methylated form MβCD was found ... Cyclodextrins were also shown to enhance mucosal penetration of drugs. β-cyclodextrins are used to produce stationary phase ...
α-Cyclodextrin is a hexasaccharide derived from glucose. It is related to the β- (beta) and γ- (gamma) cyclodextrins, which ... All cyclodextrins are white, water-soluble solids with minimal toxicity. Cyclodextrins tend to bind other molecules in their ... Then cyclodextrin glycosyltransferase (CGTase) is added for enzymatic conversion. CGTases produce diverse cyclodextrins. The ... The exterior surface of cyclodextrins is somewhat hydrophilic whereas the interior core is hydrophobic. α-Cyclodextrin is ...
Branched cyclodextrins are produced by the pyrolysis of cyclodextrins. The temperature range is 135 C. to 220 C. using ... The advantage of branched cyclodextrins over cyclodextrins and especially branched beta cyclodextrins over beta cyclodextrins ... crystalline cyclodextrin is beta cyclodextrin and the branched cyclodextrin is branched beta cyclodextrin. ... crystalline cyclodextrin is beta cyclodextrin and the branched cyclodextrin is branched beta cyclodextrin. ...
Techno-economic analyses of specific alpha cyclodextrin production processes, presenting capital investment breakdown, raw ... ECONOMICS OF ALPHA-CYCLODEXTRIN PRODUCTION FROM CORN (ALPHA-CYCLODEXTRIN E12A) It presents the economics of alpha-Cyclodextrin ... Cyclodextrin production costs Industrial Process Economics About Alpha-Cyclodextrin Reports Coverage of Alpha-Cyclodextrin ... ALPHA-CYCLODEXTRIN E11A) This report presents the economics of alpha-Cyclodextrin production from corn in the USA, using a ...
About CYCLODEXTRIN: Cyclodextrin is a cyclic polysaccharide comprised of six to eight glucopyranose units.. Function(s): ... Synonym(s): .BETA.-CYCLODEXTRIN; ALPHADEX; BETADEX; CYCLOAMYLOSE; CYCLOHEPTAPENTYLOSE; BETA-CYCLOAMYLOSE; BETA- ...
Structural representations of β-cyclodextrin, α-cyclodextrin, and γ-cyclodextrin. The cyclodextrins are cyclic oligosaccharides ... Cyclodextrins Product Name. Formula. Mol Wt.. Assay (%). Application. Solubility. Cat. No.. α-Cyclodextrin. C36H60O30. 972.84. ... 2-Hydroxypropyl)-γ-cyclodextrin. -. -. -. -. H2O 450 mg/mL. H125. Methyl-β-cyclodextrin extent of labeling 1.5 - 2.1 methyl per ... 2-Hydroxypropyl)-β-cyclodextrin. -. -. -. -. H2O 45 % (w/v). H107. (2-Hydroxypropyl)-β-cyclodextrin. extent of labeling 4 - 10 ...
... Bridging ligand holds scaffold in position to make strained oligomers by Celia Arnaud April ... The most common cyclodextrins, CD6, CD7, and CD8, are made commercially via enzymatic processes. The smallest one previously ... Cyclodextrins are cyclic oligomers of glucose. Their central cavities can hold small molecules, making them attractive for ... 4-glycosidic bond formation needed to make the desired strained cyclodextrins. Although the researchers were able to obtain CD3 ...
ß-CYCLODEXTRIN. WHO Food Additives Series, No. 35, 1996, No. 843 (inchem). ... ß-CYCLODEXTRIN. WHO Food Additives Series, No. 35, 1996, No. 843 (inchem). ... ß-CYCLODEXTRIN. WHO Food Additives Series, No. 35, 1996, No. 843 (inchem). ...
The aim of this chapter is to describe the practical aspects, and current and potential applications of cyclodextrins in ... The last section focuses on the effect of cyclodextrins on reactions undergone by some nitroso compounds and on some ... Notify me of updates to Cyclodextrins in Nitrosation Chemistry, pp. 1-44. ... The first section describes physico-chemical aspects of aqueous cyclodextrin. solutions relative to mechanistic studies. The ...
... with gamma-cyclodextrin boosted bioavailability of CoQ10 by about 35 per cent compared to a microcrystalline cellulose-CoQ10 ... Complexing co-enzyme Q10 (CoQ10) with gamma-cyclodextrin boosted bioavailability of CoQ10 by about 35 per cent compared to a ... CycloChem and Wacker-Chemie are both gamma-cyclodextrin producers, with Wacker claiming to be the worlds leading producer of ... suggesting the potential use of gamma-cyclodextrin for an oral capsule formulation containing CoQ10 powder,"​ wrote lead author ...
Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Beta cyclodextrins bind and remove A2E from RPE. Marcelo M. Nociari, Guillermo L. Lehmann, Andres E. Perez Bay, Roxana A. Radu ... Cyclodextrin stock solutions were prepared at 100 mM in PBS buffer (pH 7.2) except for β-CD system, which, due to the ... 2011) Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin. Curr Opin Lipidol 22(3):204-209. ...
Their extraction with as mild conditions as possible led to its investigation using cyclodextrins as a tool. The inclusion ... Application of Cyclodextrins to the Extraction of Antioxidant Compounds from Olive Oil. ...
The preferred perfume/cyclodextrin complexes, either alone or admixed with solvent (e.g., water), are preferably suspended in ... Cyclodextrin complex is suspended in polyalkylene glycol carrier material that does not displace the included material. ... Preferably at least a major portion of the cyclodextrins are alpha-cyclodextrin, beta-cyclodextrin, and/or gamma-cyclodextrin, ... 1. Cyclodextrins. As used herein, the term "cyclodextrin" (CD) includes any of the known cyclodextrins such as unsubstituted ...
Solutions of (a) 20 mL 5% chitosan, (b) 40 mL 5% β-cyclodextrin, and (c) 20 mL 5% chitosan + 40 mL β-cyclodextrin were diluted ... Hydroxyl group on the β-cyclodextrin and hydroxyl group on the chitosan or amino interact when the compounds of β-cyclodextrin ... β-cyclodextrin. After 12 days, the MDA content of those coated with chitosan + β-cyclodextrin was 0.83 mmol/g, 35.7% lower than ... β-cyclodextrin. The respiration rate of those coated with chitosan + β-cyclodextrin was lower than that of those coated with ...
The food enzyme β‐cyclodextrin glucanotransferase ((1→4)‐α‐d‐glucan 4‐α‐d‐[(1→4)‐α‐d‐glucano]‐transferase; EC 2.4.1.19) is ... It is intended to be used in starch processing for the production of γ‐cyclodextrin. Residual amounts of total organic solids ... food enzyme, β‐cyclodextrin glucanotransferase, cyclomaltodextrin glucosyltransferase, β‐CGTase, EC 2.4.1.19, Escherichia coli ... In the absence of information about the sequence homology of this β‐cyclodextrin glucanotransferase with known allergens, the ...
The compositions can further comprise cyclodextrin-compatible and -incompatible materials, and other optional ingredients. ... A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin ... branched cyclodextrins, cationic cyclodextrins, anionic cyclodextrins, amphoteric cyclodextrins and cyclodextrins wherein at ... branched cyclodextrins, cationic cyclodextrins, anionic cyclodextrins, amphoteric cyclodextrins and cyclodextrins wherein at ...
Abstract Cyclodextrin-enhanced roo... Introduction Cyclodextrins (CDs) a...,Cyclodextrin,enhances,room,temperature, ... Cyclodextrin enhances room temperature phosphorescence. ... Abstract Cyclodextrin-enhanced roo... Introduction Cyclodextrins ( ... This inclusion capability has led to an important use of cyclodextrins in luminescence spectroscopy. Cyclodextrins have been ... Cyclodextrins (CDs) are made up of glucose monomers coupled to form a rigid, conical structure with an interior hydrophobic ...
Cyclodextrin Chemistry Conference is for the researchers, scientists, scholars, engineers, academic, scientific and university ... Cyclodextrin Chemistry. International Conference on Cyclodextrin Chemistry. Cyclodextrin Chemistry Conference aims to bring ... and concerns as well as practical challenges encountered and solutions adopted in the fields of Cyclodextrin Chemistry ... experiences and research results on all aspects of Cyclodextrin Chemistry Conference. It also provides a premier ...
Delivering co-enzyme Q10 complexed with beta-cyclodextrin may increase the bioavailability of the nutrient, with the benefits ... Lifton told this website that beta-cyclodextrin is allowed in Europe whereas gamma-cyclodextrin is currently forbidden in ... CoQ10 bioavailability boost from cyclodextrin complex. By Stephen Daniells 12-Mar-2010. - Last updated on 01-Apr-2010 at 07:34 ... The cyclodextrin used in the Micro-Active CoQ10 ingredient is derived from potato starch and is non-GMO, added Maypro. ...
Horikoshi, K. and Nakamura, N. in Proceedings of the First International Symposium on Cyclodextrins (Szejtli, J.,ed.) P25-39 ( ... Hashimoto H. (1988) Application of Cyclodextrins to Foods, Toiletries and Other Products in Japan. In: Huber O., Szejtli J. ( ... Proceedings of the Fourth International Symposium on Cyclodextrins pp 533-543 , Cite as ... eds) Proceedings of the Fourth International Symposium on Cyclodextrins. Advances in Inclusion Science, vol 5. Springer, ...
... α-cyclodextrin), W7 (β-cyclodextrin) and W8 (γ-cyclodextrin). ... world to produce all three naturally occurring cyclodextrins, ... β-cyclodextrin) and W8 (γ-cyclodextrin). The cyclodextrin derivatives produced by modifying these α-, β- and γ-cyclodextrins by ... Cyclodextrins. With this method, we produce three different CAVAMAX® cyclodextrins, which are identical to the ones found in ... Depending on the size of the ring, a distinction is made between α-cyclodextrin with six, β-cyclodextrin with seven and γ- ...
Looking for TCI AMERICAS Trimethyl-Beta-Cyclodextrin, 1g (19XC33)? Graingers got your back. Price:$159.65. Easy ordering & ...
The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the ... Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex. Maddukuri Sravya,1 Rajamanickam ... This work proved β-cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs. ... Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β-cyclodextrin were ...
A wide variety of beta-cyclodextrin options are available to you, such as food grade, cosmetic grade, and tech grade. ... Alibaba.com offers 5,826 beta-cyclodextrin products. About 48% of these are auxiliaries and other medicinal chemicals, 26% are ... sulfobutyl ether beta-cyclodextrin sulfobutylether beta-cyclodextrin gmp beta-cyclodextrin glucose beta-cyclodextrin beta- ... beta-cyclodextrin top purity beta-cyclodextrin high purity beta-cyclodextrin top quality beta-cyclodextrin beta-cyclodextrin ...
The NOEL in this study was 1.25% -cyclodextrin in the diet, equal to a mean achieved -cyclodextrin intake which ranged from 560 ... See Also: Toxicological Abbreviations Beta-Cyclodextrin (WHO Food Additives Series 32) beta-CYCLODEXTRIN (JECFA Evaluation) ... cyclodextrin complex, showing that vitamin A does not interact with -cyclodextrin in the presence of these bile acids. Similar ... cyclodextrin, the affinity of sodium cholate and sodium taurocholate for -cyclodextrin being weaker than that of sodium ...
See Also: Toxicological Abbreviations beta-Cyclodextrin (WHO Food Additives Series 35) beta-CYCLODEXTRIN (JECFA Evaluation) ... cyclodextrin at dietary levels of 1.25, 2.5, 5 or 10%, equal to mean daily doses of 570, 1 234, 2 479 or 4 598 mg -cyclodextrin ... cyclodextrin increased in a dose-dependent manner and with time after dosing up to 6 hours. No -cyclodextrin was detected in ... cyclodextrin and starch (Andersen et al. 1963). -Cyclodextrin, purity >77%, and glucose, uniformly labelled with 14C, were ...
In our current work, an azobenzene-modified β-cyclodextrin (β-CD) derivative that can form a self-inclusion complex in aqueous ... Keywords: azobenzene; complexation; cyclodextrin; gold nanoparticle; [1]rotaxane azobenzene; complexation; cyclodextrin; gold ... Zhu, L.; Yan, H.; Zhao, Y. Cyclodextrin-Based [1]Rotaxanes on Gold Nanoparticles. Int. J. Mol. Sci. 2012, 13, 10132-10142. ... In our current work, an azobenzene-modified β-cyclodextrin (β-CD) derivative that can form a self-inclusion complex in aqueous ...
... and γ-cyclodextrin (CD) were efficiently synthesized. These compounds formed stable monolayers with high collapse pressures at ... and β-Cyclodextrins and Hexakis(6-deoxy-6-thio-2,3-di-O-pentyl)-α-Cyclodextrin at an Air-Water Interface. Tetrahedron Letters, ... Chmurski, K., Bilewicz, R. and Jurczak, J. (1996) Monolayer Behavior of [6-Deoxy-6-S-phenyl]-α-, β-, and γ-cyclodextrins at the ... Ashton, P.R., Königer, R. and Stoddart, J.F. (1996) Amino Acid Derivatives of β-Cyclodextrin. Journal of Organic Chemistry ...
The purpose of this study was to develop a novel mucoadhesive thiolated and S-protected gamma cyclodextrin (γ-CD) with an ... Cyclodextrins are popular drug solubilizers, but the use of the natural cyclodextrins is hampered by their tendency to co- ... Cyclodextrin complexes: Perspective from drug delivery and formulation.. Cyclodextrins (CDs) have been widely investigated as a ... Cyclodextrins. A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of ...
The cyclodextrin also dissolves cholesterol crystals so that the cholesterol can be excreted from the body in urine. The result ... Cyclodextrin works by reprogramming macrophages so that they do not cause such a strong inflammatory response in blood vessels ... The original idea for the test of cyclodextrin came from Chris Hempel, an American mother whose twin daughters are affected by ... The children are being treated with cyclodextrin with promising results. Hempel read about previous research on cholesterol ...
  • With a hydrophobic interior and hydrophilic exterior, cyclodextrins form complexes with hydrophobic compounds. (wikipedia.org)
  • In contrast, the exterior is sufficiently hydrophilic to impart cyclodextrins (or their complexes) water solubility. (wikipedia.org)
  • Sigma's product line of water-soluble complexes includes cyclodextrins and soluble cyclodextrin-complexes of biochemicals commonly used in tissue and cell culture applications. (sigmaaldrich.com)
  • The preferred perfume/cyclodextrin complexes, either alone or admixed with solvent (e.g., water), are preferably suspended in the carrier and then incorporated into solid, dryer-activated, fabric treatment (conditioning) compositions, preferably containing fabric softeners, more preferably cationic and/or nonionic fabric softeners. (google.ca)
  • and mixtures thereof, and wherein said cyclodextrin is capable of forming inclusion complexes with said active. (google.ca)
  • Because these included water molecules are easily displaced by hydrophobic species that will fit into the CD interior, cyclodextrins have a unique ability to form stable inclusion complexes with a variety of molecules. (bio-medicine.org)
  • Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β -cyclodextrin were used for formulating orodispersible tablets by direct compression with different superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate, and low substituted hydroxypropyl cellulose in varying concentrations. (hindawi.com)
  • Cyclodextrin complexes: Perspective from drug delivery and formulation. (bioportfolio.com)
  • Beta-cyclodextrins (b-CDs) are small cyclic oligosaccharides that can form inclusion complexes with cholesterol, and are commonly used to manipulate cholesterol levels of biomembranes. (rug.nl)
  • We have 4 series (Medical Cyclodextrins, Cyclodextrin Reagents, Cyclodextrin Complexes, Cyclodextrin Polymers ) of more than 40 kinds of cyclodextrins now. (opencroquet.org)
  • Inclusions of lidocaine hydrochloride in cyclodextrins were prepared to obtain stable complexes compatible for association with chlorhexidine in a new gel formulation for use in urogenital applications. (dovepress.com)
  • The lidocaine-cyclodextrin complexes were characterized by ultraviolet spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. (dovepress.com)
  • Molecular inclusion complexes using cyclodextrins have become a standard formulation strategy to mainly improve the solubility or stability of active ingredients. (roquette.com)
  • Another way to develop NSAIDs with better GI tolerability is to complex these molecules with cyclodextrins (CDs), giving rise to so-called "inclusion complexes" that can have physical, chemical and biological properties very different from either those of the drug or the cyclodextrin. (eurekaselect.com)
  • Carvalho LB, Pinto LMA (2012) Formation of inclusion complexes and controlled release of atrazine using free or silica-anchored β-cyclodextrin. (springer.com)
  • Among many characterization methods that are applicable in both solution and solid state, thermal techniques were widely used for analysis and stability evaluation of cyclodextrin complexes. (springer.com)
  • We review the use of thermal methods for the analysis of cyclodextrin complexes and non-complexed cyclodextrins. (springer.com)
  • Cyclodextrin complexes are classified according to the types of biological activity of the guest compound, e.g. drugs, odorants, essential oils and vegetable extracts, antioxidants, fatty acids, oils and fatty acid based derivatives, and other organic, organometallic and inorganic compounds. (springer.com)
  • The formation of cyclodextrin inclusion complexes is evidenced by disappearance of the thermal characteristics of the guest compound after nanoencapsulation. (springer.com)
  • Abarca RL, Rodríguez FJ, Guarda A, Galotto MJ, Bruna JE (2016) Characterization of beta-cyclodextrin inclusion complexes containing an essential oil component. (springer.com)
  • Badr-Eldin SM, Elkheshen SA, Ghorab MM (2008) Inclusion complexes of tadalafil with natural and chemically modified β-cyclodextrins. (springer.com)
  • This work aimed to develop ODTs of poorly soluble drugs by combining cyclodextrins that form inclusion complexes to improve wetting and release properties, and directly compressible co-processed excipients able to promote rapid disintegration and solve the poor flowability typical of inclusion complexes. (unboundmedicine.com)
  • From them we derived the stability constants of the inclusions complexes nimodipine-cyclodextrin (1:1) as well as the empirical linear equations for the calculation of the saturated nimodipine concentration at a given cyclodextrin concentration. (unboundmedicine.com)
  • Cyclodextrins (CDs) are capable of forming inclusion complexes with many drugs. (pubmedcentralcanada.ca)
  • The inclusion complexes of rifampicin with sucralose and β-cyclodextrins were prepared by spray drying method. (ijpsonline.com)
  • Synthesis and biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal agents. (bioportfolio.com)
  • We study βLAP and its derivative nor-β-Lapachone (NβL) complexes with 2-hydroxypropyl-β-cyclodextrin to increase the solubility and bioavailability. (bioportfolio.com)
  • Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape: α (alpha)-cyclodextrin: 6 glucose subunits β (beta)-cyclodextrin: 7 glucose subunits γ (gamma)-cyclodextrin: 8 glucose subunits Cyclodextrins are ingredients in more than 30 different approved medicines. (wikipedia.org)
  • Techno-economic analyses of specific alpha cyclodextrin production processes, presenting capital investment breakdown, raw materials consumed and operating costs. (slideshare.net)
  • 1. Know the capital investment required Examine the operating costs & raw materials consumption Alpha-Cyclodextrin is a polysaccharide and a multifunctional, soluble dietary fiber marketed for use as a fiber ingredient, an odor or flavor masking agent, and for emulsification applications. (slideshare.net)
  • The Intratec portfolio (www.intratec.us/our-portfolio) includes reports examining specific Alpha- Cyclodextrin production processes. (slideshare.net)
  • For a 10-page description of our methodology, visit www.intratec.us/reports/industrial-processes-economics Reports Focused on Alpha-Cyclodextrin Production Economics ECONOMICS OF ALPHA-CYCLODEXTRIN PRODUCTION FROM CORN (ALPHA-CYCLODEXTRIN E11A) This report presents the economics of alpha-Cyclodextrin production from corn in the USA, using a solvent process. (slideshare.net)
  • Different from the report 'Alpha-Cyclodextrin E11A', the process examined in this report is a non-solvent process. (slideshare.net)
  • 5. A composition according to claim 1 wherein said composition further comprises non-derivatized cyclodextrin selected from the group consisting of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, and mixtures thereof. (google.com.au)
  • 1984). In a preliminary comparative metabolism study in rats, groups each of 2 animals were given 14 C-labelled alpha-cyclodextrin, -cyclodextrin or gelatinised potato starch by gavage as approximately 2.5 ml of a 2.5% aqueous solution. (inchem.org)
  • Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha cyclodextrin (αCD) threaded onto poly(ethylene glycol) (PEG), have attracted interest as a result of their ability to overcome physical limitations present in conventional, covalently structured polymers. (rsc.org)
  • The used cyclodextrins were native beta-cyclodextrin (beta-CD), its derivatives hydroxyethyl-beta-CD (HE-beta-CD), three hydroxypropyl-beta-CD (HP-beta-CD) with various degree of substitution and methyl-beta-CD (M-beta-CD), native alpha-cyclodextrin (alpha-CD), hydroxypropyl-alpha-CD (HP-alpha-CD) and hydroxypropyl-gamma-CD (HP-gamma-CD). (unboundmedicine.com)
  • Dodecyl glucooligosides, a class of interesting non ionic surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin (alpha-CD) or soluble starch as glycosyl donor and dodecyl beta-D-glucoside (C(12)G(1)) or dodecyl beta-D-maltoside (C(12)G(2)) as acceptor substrates. (lu.se)
  • Cavity size is the major determinant as to which cyclodextrin is used in complexation. (sigmaaldrich.com)
  • γ-Cyclodextrins have much larger cavities than many molecules to be incorporated, and cyclodextrin hydrophobic charges cannot effectively interact to facilitate complexation. (sigmaaldrich.com)
  • "The results indicate that the oral absorption and bioavailability of CoQ10 could be significantly enhanced by the complexation with gamma-cyclodextrin, suggesting the potential use of gamma-cyclodextrin for an oral capsule formulation containing CoQ10 powder," ​ wrote lead author Keiji Terao in the journal Nutrition Research ​ (Vol. 26, pp. 503-508). (nutraingredients-usa.com)
  • The complexation of Q10 with cyclodextrins was reportedly first studied in mid-nineties, and previously, researchers from Wacker-Chemie reported improved bioavailability for CoQ10 when complexed with gamma-cylcodextrin. (nutraingredients.com)
  • The aim of this study was to investigate the use of inclusion complexation technique employing β -cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into orodispersible tablets. (hindawi.com)
  • Complexation of NSAIDs with β-cyclodextrin potentially leads to a more rapid onset of action after oral administration and improved GI tolerability because of minimization of the drug gastric effects. (eurekaselect.com)
  • Alvarez-Parrilla E, de la Rosa LA, Torres-Rivas F, Rodrigo-Garcia J, González-Aguilar GA (2005) Complexation of apple antioxidants: chlorogenic acid, quercetin and rutin by β-cyclodextrin (β-CD). (springer.com)
  • Complexation with cyclodextrins (βCD) has been reported to enhance the solubility and permeation of poorly water soluble drugs, through the biological membranes. (ijpsonline.com)
  • Aryl Phosphate Complexation by Cationic Cyclodextrins. (figshare.com)
  • The enthalpies and entropies for phosphate complexation by ammonium and guanidinium groups have been compared using cationic cyclodextrins. (figshare.com)
  • A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. (google.com.au)
  • We expect our research in this area will contribute to the design of more effective cyclodextrin derivatives for medical treatment of lipid metabolism pathologies, like for example in the treatment of Niemann-Pick type C disease. (rug.nl)
  • It is a leading manufacturer and supplier of cyclodextrin derivatives in China. (opencroquet.org)
  • As the base of research, development, production and sales for Cyclodextrin Derivatives, our R&D team that are formed by domestic and overseas experts in the field of cyclodextrin. (opencroquet.org)
  • However, confusion is currently made in the literature between the different methylated cyclodextrin derivatives. (nih.gov)
  • We studied the influence of natural cyclodextrins (betaCD and gammaCD), methylated derivatives (2,6-dimethyl-betaCD (Dimeb), 2,3,6-trimethyl-betaCD (Trimeb) and randomly methylated-betaCD (Rameb), as well as the new derivative Crysmeb), hydroxypropylated derivatives (HPbetaCD of different substitution degrees and HPgammaCD) and the sulfobutylated derivative (SBEbetaCD) on the release of a fluorescent marker encapsulated in the inner cavity of liposomes. (nih.gov)
  • We report the effect of native cyclodextrins (alpha, beta, and gamma) and selected derivatives in modulating the self-assembly of the nonionic surfactant polyoxyethylene cholesteryl ether (ChEO(10)) and its mixtures with triethylene glycol monododecyl ether (C12EO3), which form wormlike micelles. (diva-portal.org)
  • Bettinetti GP, Sorrenti M, Rossi S, Ferrari F, Mura P, Faucci MT (2002) Assessment of solid-state interactions of naproxen with amorphous cyclodextrin derivatives by DSC. (springer.com)
  • Among the chitosan derivatives, cyclodextrin-grafted chitosan and poly(ethylene glycol)-grafted chitosan are excellent candidates for a range of biomedical, environmental decontamination, and industrial purposes. (frontiersin.org)
  • This work discusses modifications including chitosan with attached cyclodextrin and poly(ethylene glycol), and the main applications of these chitosan derivatives in the biomedical field. (frontiersin.org)
  • The objective was to evaluate the effect of two ßcyclodextrins derivatives: (KLEPTOSE® HPB hydroxypropyl-ß-cyclodextrin, with MS=0.65) and (KLEPTOSE® HP hydroxypropyl-ß-cyclodextrin, with MS=0.9) on two biologic drugs (Infliximab and Etanercept) aggregation using high-throughput formulation screening (iFormulate™) and nanoDSF (Differential Scanning Fluorimetry) (3,4). (bioprocessintl.com)
  • Abstract Cyclodextrin-enhanced roo. (bio-medicine.org)
  • Abstract - The inclusion interaction of ibuprofen with hydroxypropyl-β-cyclodextrin (HP-β-CD), hydroxyethyl-β-cyclodextrin (HE-β-CD) and methyl-β-cyclodextrin (Me-β-CD) was investigated by fluorescence spectroscopy. (scielo.org.ar)
  • Commonly cyclodextrin glycosyltransferase (CGTase) is employed along with α-amylase. (wikipedia.org)
  • CGTases produce mixtures of cyclodextrins, thus the product of the conversion results in a mixture of the three main types of cyclic molecules, in ratios that are strictly dependent on the enzyme used: each CGTase has its own characteristic α:β:γ synthesis ratio. (wikipedia.org)
  • Then cyclodextrin glycosyltransferase (CGTase) is added for enzymatic conversion. (wikipedia.org)
  • Conventionally, cyclodextrins are formed by the action of an enzyme, cyclodextrin-glycosyl-transferase (CGTase), on a starch substrate, starch, or a starch hydrolysate having a dextrose equivalent (DE) less than 10. (google.com)
  • Cyclodextrin glycosyltransferase (CGTase) is one of the most important groups of microbial amylolytic enzymes that have been used for degradation of starch to yield cyclodextrin (CD) via cyclization reaction. (academicjournals.org)
  • Cyclodextrin glycosyl tranferase or Cyclodextrin glucosyltransferas or Cyclodextrin glucanotransferase or CGTase is a bacterial enzyme belonging to the same family. (omicsonline.org)
  • Cyclodextrin glycosyltransferase (CGTase) is an enzyme that produces cyclodextrins (CDs) from starch and related carbohydrates, producing a mixture of α-, β-, and γ-CDs in different amounts. (frontiersin.org)
  • Cyclodextrins (CDs) are synthesized from starch and related carbohydrates such as amylose, amylopectin and maltooligosaccharide by cyclodextrin glycosyltransferase (CGTase, E.C.2.4.1.19) which is a bacterial extracellular enzyme ( Ahmed and El-Refai, 2010 ). (frontiersin.org)
  • Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds. (wikipedia.org)
  • The largest cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. (wikipedia.org)
  • The cyclodextrins are cyclic oligosaccharides consisting of 7, 6, or 8 (respectively) glucopyranose units. (sigmaaldrich.com)
  • The Micro-Active CoQ10 ingredient, manufactured by BioActives and distributed by Maypro, is composed of CoQ10 complexed with cyclodextrin and oligosaccharides. (nutraingredients.com)
  • Cyclodextrins are naturally occurring oligosaccharides. (wacker.com)
  • Alpha-cyclodextrins are ring-shaped oligosaccharides that have a hydrophilic exterior and a lipophilic cavity. (foodbusinessnews.net)
  • Cyclodextrins are cyclic oligosaccharides comprising of six to eight α-(1→4)-linked d -glucopyranose units corresponding to the natural α-, β- and γ-cyclodextrin, respectively. (springer.com)
  • Cyclodextrins are cyclic oligosaccharides composed of six to eight units of glucopyranosyl connected by α-(1→4) linkages ( Davis and Brewster, 2004 ). (frontiersin.org)
  • Cyclodextrins (CyDs) are cyclic oligosaccharides consisting of six to eight glucose residues. (go.jp)
  • For drug delivery, this cyclodextrin confers aqueous solubility to hydrophobic drugs and stability to labile drugs. (wikipedia.org)
  • The degree of chemical substitution and the nature of the groups used for substitution determine the final maximum concentration of cyclodextrin in an aqueous medium. (sigmaaldrich.com)
  • The first section describes physico-chemical aspects of aqueous cyclodextrin solutions relative to mechanistic studies. (novapublishers.com)
  • 1963). -Cyclodextrin, purity >77%, and glucose, uniformly labelled with 14 C, were administered to rats by gavage as solutions in 20% aqueous dextran at dose levels of 13 mg/kg bw for glucose and 36 and 313 mg/kg bw for -cyclodextrin. (inchem.org)
  • In our current work, an azobenzene-modified β-cyclodextrin (β-CD) derivative that can form a self-inclusion complex in aqueous solution was prepared. (mdpi.com)
  • The effect of cyclodextrins (α-CD, β-CD and γ-CD) on the thermosensitivity and fluorescence of the copolymers in aqueous solutions were investigated. (mdpi.com)
  • The precipitated cyclodextrin is then collected and an aqueous solution of complexant and cyclodextrin is heated to disrupt the complex and drive off the complexant, leaving the cyclodextrin in solution. (google.com)
  • Carvalho LB, Carvalho TG, Magriotis ZM, Ramalho TC, Pinto LMA (2014) Cyclodextrin/silica hybrid adsorbent for removal of methylene blue in aqueous media. (springer.com)
  • During the past fifteen years, the use of chemically modified cyclodextrins (CDs) in aqueous organometallic catalysis has significantly contributed to enlarge the application field of biphasic processes in chemistry. (eurekaselect.com)
  • H. Bricout, F. Hapiot, A. Ponchel, S. Tilloy and E. Monflier, " Cyclodextrins as Mass Transfer Additives in Aqueous Organometallic Catalysis", Current Organic Chemistry (2010) 14: 1296. (eurekaselect.com)
  • The results of a comprehensive study of the dissolution of the calcium antagonist nimodipine in aqueous solutions of nine cyclodextrins are reported. (unboundmedicine.com)
  • Kopecký F, Kopecká B, Kaclík P. [Dissolution of nimodipine in an aqueous solution of hydroxyethyl-beta-cyclodextrin and a review of solubility of nimodipine with cyclodextrins]. (unboundmedicine.com)
  • The inclusion compounds of cyclodextrins with hydrophobic molecules are able to penetrate body tissues, these can be used to release biologically active compounds under specific conditions. (wikipedia.org)
  • Purification of the three types of cyclodextrins takes advantage of the different water solubility of the molecules: β-CD which is poorly water-soluble (18.5 g/l or 16.3mM) (at 25C) can be easily retrieved through crystallization while the more soluble α- and γ-CDs (145 and 232 g/l respectively) are usually purified by means of expensive and time consuming chromatography techniques. (wikipedia.org)
  • Cyclodextrins tend to bind other molecules in their quasi-cylindrical interiors. (wikipedia.org)
  • α-Cyclodextrins have small cavities that are not capable of accepting many molecules. (sigmaaldrich.com)
  • Hydrophobic molecules are incorporated into the cavity of cyclodextrins by displacing water. (sigmaaldrich.com)
  • 1. A composition for capturing unwanted molecules, said composition comprising low degree of substitution cyclodextrin derivative and a perfume material wherein said low-degree of substitution cyclodextrin derivative is selected from the group consisting of hydroxyalkyl cyclodextrin having an average degree of substitution of less than about 4.5, alkylated cyclodextrin having an average degree of substitution of less than about 6.0, and mixtures thereof. (google.com.au)
  • When polynuclear aromatic hydrocarbons (PAHs) are included in cyclodextrin molecules in the presence of a heavy-atom moiety such as 1,2-dibromoethane, they exhibit intense, well-defined phosphorescence emissions, often with distinct vibrational structure. (bio-medicine.org)
  • Cyclodextrins have been found to enhance fluorescent and phosphorescent emissions from molecules present in the CD cavity. (bio-medicine.org)
  • The isolated enzyme helps to convert starch into cyclodextrins, ring-shaped glucose molecules. (wacker.com)
  • As a result of its cyclic structure, -cyclodextrin has the ability to form inclusion compounds with a range of molecules, generally of molecular mass of less than 250. (inchem.org)
  • Because of their ringed structure, cyclodextrins are most noted for their ability to act as a host compound for other molecules (guest compounds). (google.com)
  • Modification of the carbohydrate cyclodextrin increases the ability to encapsulate hydrophobic pharmaceutical molecules by forming a carrier with a hydrophobic core and hydrophilic exterior. (calpoly.edu)
  • Vesicles are formed by hydrating a thin film of amphiphilic cyclodextrin and guest molecules in buffer solution that mimics physiological conditions. (calpoly.edu)
  • Cyclodextrins are produced from starch by enzymatic conversion. (wikipedia.org)
  • Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). (wikipedia.org)
  • Cyclodextrins are prepared by enzymatic treatment of starch. (wikipedia.org)
  • The complex formation drives the conversion of starch towards the synthesis of the precipitated cyclodextrin, thus enriching its content in the final mixture of products. (wikipedia.org)
  • Cyclodextrins are natural starch-conversion products. (wikipedia.org)
  • It is intended to be used in starch processing for the production of γ‐cyclodextrin. (europa.eu)
  • The cyclodextrin used in the Micro-Active CoQ10 ingredient is derived from potato starch and is non-GMO, added Maypro. (nutraingredients.com)
  • It is produced by the action of the enzyme, cyclodextrin glycosyl transferase (CGT), on hydrolyzed starch syrups. (inchem.org)
  • A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. (bioportfolio.com)
  • Cyclodextrin, cyclodextrin glycosyltransferase, starch. (academicjournals.org)
  • Furuike, T., Aiba, S. and Nishimura, S.-I. (2000) A Highly Practical Synthesis of Cyclodextrin-Based Glycoclusters Having Enhanced Affinity with Lectins. (scirp.org)
  • The invention describes a process for the synthesis of cyclodextrins in gram quantities composed of 9 and more glucose units while previously the preparation of large-ring cyclodextrins has been limited to a few mg. (innovations-report.com)
  • Y. Gao, Y. Cao, G. Song, Y. Tang and H. Li, " β -cyclodextrin Covalently Functionalized Single-Walled Carbon Nanotubes: Synthesis, Characterization and a Sensitive Biosensor Platform," Journal of Biomaterials and Nanobiotechnology , Vol. 2 No. 4, 2011, pp. 454-460. (scirp.org)
  • This was achieved through a six-step synthesis resulting in a lanthanide-salen-cyclodextrin complex. (diva-portal.org)
  • They are the main ingredient in Febreze which claims that the β-cyclodextrins "trap" odor causing compounds, thereby reducing the odor. (wikipedia.org)
  • A frequently used approach is to use cyclodextrin as a "carrier" molecule to facilitate the dissolution of these compounds. (sigmaaldrich.com)
  • The cavity diameter of β-cyclodextrins has been found to be the most appropriate size for hormones, vitamins, and other compounds frequently used in tissue and cell culture applications. (sigmaaldrich.com)
  • The last section focuses on the effect of cyclodextrins on reactions undergone by some nitroso compounds and on some nitrosation reactions that produce nitroso compounds. (novapublishers.com)
  • β -Cyclodextrin is one of supramolecular compounds and has many particular properties such as emulsion, moisturizing, and inclusion. (hindawi.com)
  • The present invention relates to a process for the preparation of inclusion compounds of piroxicam with β-cyclodextrin. (freepatentsonline.com)
  • 1. A process for the preparation of piroxicam:β-cyclodextrin inclusion compounds, comprising the following steps: a) dissolving piroxicam and β-cyclodextrin in the presence of ammonium hydroxide in a suitable tank containing water at a temperature of at least 60° C. (freepatentsonline.com)
  • Cyclodextrins (CD) are cyclic oligosaccharide compounds widely used to bind cholesterol. (rupress.org)
  • Cyclodextrins can protect these compounds against light and oxidative degradation by molecular encapsulation. (springer.com)
  • Moreover, cyclodextrins can also enhance properties of biologically active compounds such as better water solubility and bioavailability, and controlled release. (springer.com)
  • Cyclodextrins(CDs) are macrocyclic compounds with several D-glucopyranoses residues linked by α-1,4-glycosidic bonds. (scielo.org.ar)
  • In the absence of information about the sequence homology of this β‐cyclodextrin glucanotransferase with known allergens, the Panel could not complete the assessment on the allergenicity of the food enzyme. (europa.eu)
  • The Panel concludes that the food enzyme β‐cyclodextrin glucanotransferase produced with the genetically modified E. coli strain WCM105xpCM6420 cannot be considered safe. (europa.eu)
  • The previously reported structural model of cyclodextrin glycosyltransferase (EC 2.4.1.19) from Bacillus circulans has been improved. (rcsb.org)
  • 2. A composition according to claim 1 wherein said low-degree of substitution cyclodextrin derivative is selected from the group consisting of hydroxyalkyl cyclodextrin having an average degree of substitution of less than about 4.5, alkylated cyclodextrin having an average degree of substitution of less than about 5.5, and mixtures thereof. (google.com.au)
  • Moreover, a new methylated cyclodextrin derivative recently occurred in the market, the Crysmeb. (nih.gov)
  • Three-armed star polymers with a cyclodextrin core and polyacrylamide arms were prepared via inclusion complex formation. (rsc.org)
  • All cyclodextrins are white, water-soluble solids with minimal toxicity. (wikipedia.org)
  • This effectively encapsulates the molecule of interest within the cyclodextrin, rendering the molecule water-soluble. (sigmaaldrich.com)
  • This work proved β -cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs. (hindawi.com)
  • Carbamazepine (CBZ) and hydroxypropyl-β-cyclodextrin (HPβCD) were used, respectively, as a model of a poorly soluble drug with poor flowability and as a solubilizing agent. (unboundmedicine.com)
  • In conclusion, the combination of five-in-one co-processed excipients and hydrophilic cyclodextrins may help addressing the ODT formulation of poorly soluble drugs with poor flowability, by direct compression and with desired release properties. (unboundmedicine.com)
  • The nimodipine dissolution was studied as a function of time (up to 14 days) and cyclodextrin concentration up to 0.07 mol/l, excepting the less soluble beta-CD. (unboundmedicine.com)
  • A β-cyclodextrin (β-CD) polymer obtained by crosslinking β-CD with citric acid in its water-insoluble (PCD-I) and soluble (PCD-S) forms was used as a multifunctional direct compression excipient for tablet designing. (ovid.com)
  • The solubility of natural cyclodextrins is very poor and initially this prevented cyclodextrins from becoming effective complexing agents. (sigmaaldrich.com)
  • Cyclodextrins are popular drug solubilizers, but the use of the natural cyclodextrins is hampered by their tendency to co-precipitate with the drug. (bioportfolio.com)
  • and mixtures thereof, the weight ratio of said active/cyclodextrin inclusion complex to said solid polyalkylene glycol carrier material being from about 1:1 to about 1:5. (google.ca)
  • Drug Solubilization by Mixtures of Cyclodextrins: Additive and Synergistic Effects. (bioportfolio.com)
  • Complexing co-enzyme Q10 (CoQ10) with gamma-cyclodextrin boosted bioavailability of CoQ10 by about 35 per cent compared to a microcrystalline cellulose-CoQ10 complex, say researchers from CycloChem, Wacker-Chemie, and Kumamoto University in Japan. (nutraingredients-usa.com)
  • Delivering co-enzyme Q10 complexed with beta-cyclodextrin may increase the bioavailability of the nutrient, with the benefits experienced by all, according to a new study. (nutraingredients.com)
  • At the end of the study, Madhavi and Kagan report a 3.7-fold increase in the bioavailability, and a minimum of doubling in the plasma co-Q10 levels in all people in the CoQ10 cyclodextrin group, compared to in only 44 per cent of the people in the soft gel group. (nutraingredients.com)
  • For example, cyclodextrins can be used for stabilizing sensitive substances, for controlled release of bioactives, masking unwanted aromas, rheology control or for improving solubility and bioavailability. (wacker.com)
  • The results of an ongoing 1-year oral toxicity study in dogs and information on the effects of -cyclodextrin on the bioavailability of lipophilic nutrients were required by 1995. (inchem.org)
  • As an alternative a "complexing agent" can be added during the enzymatic conversion step: such agents (usually organic solvents like toluene, acetone or ethanol) form a complex with the desired cyclodextrin which subsequently precipitates. (wikipedia.org)
  • Cyclodextrin complex is suspended in polyalkylene glycol carrier material that does not displace the included material. (google.ca)
  • Cell disorganization increased significantly as the proportion of β -cyclodextrin present in the complex increased. (scielo.br)
  • In order to separate the cyclodextrin from the raw digest, a complexant is often employed to complex with the cyclodextrin and to cause the cyclodextrin to precipitate. (google.com)
  • The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. (scielo.br)
  • Formulated with highly absorbed Coenzyme Q10 clathrate ( -cyclodextrin complex)! (dhc.co.jp)
  • Preclinical and clinical pharmacology of PBC do show that the β-cyclodextrin inclusion complex of piroxicam is better tolerated from the upper GI tract than free piroxicam, while retaining all the analgesic and anti-inflammatory properties of the parent compound. (eurekaselect.com)
  • Ammar HO, Ghorab M, Mahmoud AA, Makram TS, Noshi SH (2012) Topical liquid crystalline gel containing lornoxicam/cyclodextrin complex. (springer.com)
  • NMR chemical shift changes of the cyclomaltoheptaose (β-cyclodextrin, β-CD) cavity protons as well as roxatidine acetate hydrochloride aromatic ring protons revealed the formation of a RAH-β-CD inclusion complex. (biomedsearch.com)
  • The present work was aimed at the influence of ethanol on the complex formation of hydroxypropyl-β-cyclodextrin (HP-β-CD) with oleanolic acid (OA) and ursolic acid (UA), two insoluble isomeric triterpenic acids. (pubmedcentralcanada.ca)
  • CYCLODEXTRIN First draft prepared by Ms F D Pollitt Health Aspects of the Environment and Food (Medical) Division Department of Health London, England Explanation Biological data Toxicological studies Short-term toxicity studies Long-term toxicity/carcinogenicity studies Reproductive toxicity studies Special studies on interactions with bile acids and lipophilic nutrients Comments Evaluation References 1. (inchem.org)
  • Beta-cyclodextrin as a new medicine anxiliary materical, is mainly used to strengthen the stability of the medicine, prevent it from oxidation and decomposition, also it can increase the solubility of the medicine, reduce the toxicity of it and cover up the odor and smell from it. (fuzing.com)
  • Cyclodextrins (CDs) are molecular carriers that can be employed to reduce the toxicity of ATZ. (springer.com)
  • The exterior surface of cyclodextrins is somewhat hydrophilic whereas the interior core is hydrophobic. (wikipedia.org)
  • Cyclodextrins (CDs) are made up of glucose monomers coupled to form a rigid, conical structure with an interior hydrophobic cavity. (bio-medicine.org)
  • Cyclodextrins are characterized by their cyclic three-dimensional structure with a hydrophobic cavity. (wacker.com)
  • Beta-cyclodextrins ( β -cds) are particularly efficient sterol acceptors, apparently because the size of their inner hydrophobic cavity matches the size of the sterol molecule (18, 28, 30, 34). (scielo.br)
  • Cyclodextrins have a truncated cone-like structure, with a hydrophobic inner cavity and highly hydrophilic exterior. (springer.com)
  • This work describes the preparation, characterization and evaluation of the nanoparticles formed by the copolymer of methyl vinyl ether and maleic anhydride (Gantrez) AN) and cyclodextrins, including beta-cyclodextrin (CD) hydroxypropyl-beta-cyclodextrin (HPCD) and 6-monodeoxy-6-monoamino-beta-cyclodextrin (NHCD). (cun.es)
  • Cyclodextrins are cyclic oligomers of glucose. (acs.org)
  • S-protected thiolated cyclodextrins as mucoadhesive oligomers for drug delivery. (bioportfolio.com)
  • Cyclodextrins are oligomers of anhydroglucose which are in a ringed structure and are named according to the number of anhydroglucose units in the ring. (google.com)
  • Cyclodextrins (CDs) are considered as probably the smallest polymeric backbone for thiomers representing some of the most broadly considered mucoadhesive excipients. (dovepress.com)
  • Geidobler, Raimund (2014): Cyclodextrins as excipients in drying of proteins and controlled ice nucleation in freeze-drying. (uni-muenchen.de)
  • Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water. (sigmaaldrich.com)
  • Branching of cyclodextrins with various mono-, di-, and tri-saccharides by Bacillus acidophilus pullulanase. (aau.dk)
  • The raw digest contains not only cyclodextrins but also linear saccharides as well as the enzyme and other components. (google.com)
  • In combination with a three-pronged β-cyclodextrin core, supramolecular self-assembly was exploited for the formation of star-shaped architectures. (rsc.org)
  • Dual pH-sensitive supramolecular micelles from star-shaped PDMAEMA based on β-cyclodextrin for drug release. (nih.gov)
  • 4. The branched cyclodextrin of claim 1 wherein the cyclodextrin is washed prior to step (a) to remove substantially all non-carbohydrate material from the cyclodextrin. (google.com)
  • 12. The branched cyclodextrin of claim 11 wherein the cyclodextrin is beta cyclodextrin. (google.com)
  • We are engaged in offering excellent quality Sodium Sulfobutyl Ether Beta Cyclodextrin SBECD 128410-00-0 to our valuable clients. (opencroquet.org)
  • In α-cyclodextrin, the six glucose subunits are linked end to end via α-1, 4 linkages. (wikipedia.org)
  • Enantiomeric separation ability on high-performance liquid chromatography (HPLC) was compared between native and acetylated β-cyclodextrin stationary phases. (go.jp)
  • Scypinski and Cline Love report, however, that intense room-temperature phosphorescence occurs when these well-known carcinogens are present, with an external heavy atom, in the cavity of cyclodextrin. (bio-medicine.org)
  • 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. (lookchem.com)
  • Crini, G. (2015) A History of Cyclodextrins. (scirp.org)
  • Crini G (2014) Review: a history of cyclodextrins. (springer.com)
  • The cyclodextrin confers solubility and stability to these drugs. (wikipedia.org)
  • Thanks to the special properties of cyclodextrins, they enable a variety of applications. (wacker.com)
  • Study of the relationship between lipid binding properties of cyclodextrins and their effect on the integrity of liposomes. (nih.gov)
  • The aim of this chapter is to describe the practical aspects, and current and potential applications of cyclodextrins in mechanistic studies that involve nitrosation reactions particularly. (novapublishers.com)
  • Loftsson, T. and Brewster, M.E. (2011) Pharmaceutical Applications of Cyclodextrins: Effects on Drug Permeation through Biological Membranes. (scirp.org)
  • Rat caecal microflora were able to utilize -cyclodextrin under anaerobic conditions in vitro, indicating that the compound may be hydrolyzed to glucose by bacterial enzymes. (inchem.org)
  • The simultaneous use of co-processing and cyclodextrin technologies rendered ODTs with an in vitro disintegration time in accordance with the European Pharmacopoeia requirement and with a fast and complete drug dissolution. (unboundmedicine.com)
  • The original idea for the test of cyclodextrin came from Chris Hempel, an American mother whose twin daughters are affected by a rare illness called Niemann-Pick Type C disease, in which cholesterol accumulates in the body. (science20.com)
  • The purpose of this study was to develop a novel mucoadhesive thiolated and S-protected gamma cyclodextrin (γ-CD) with an intact ring backbone to assure a prolonged residence time at specific target sites. (bioportfolio.com)
  • The current study was aimed at developing a novel mucoadhesive thiolated cyclodextrin (CD) without ionizable groups and an intact ring backbone for drug delivery. (dovepress.com)
  • Zhao, Y. Cyclodextrin-Based [1]Rotaxanes on Gold Nanoparticles. (mdpi.com)
  • Zhu L, Yan H, Zhao Y. Cyclodextrin-Based [1]Rotaxanes on Gold Nanoparticles. (mdpi.com)
  • The cyclodextrin-poly(anhydride) nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. (cun.es)
  • Nanoparticles displayed a size of about 150nm and a cyclodextrin content which was found optimal under the following experimental conditions: cyclodextrin/poly(anhydride) ratio of 0.25 by weight, 30min of incubation time between the cyclodextrin and the polymer. (cun.es)
  • Overall, cyclodextrin-poly(anhydride) nanoparticles displayed homogeneous bioadhesive interactions within the gut. (cun.es)
  • Simultaneous Detection of Hydroquinone and Catechol Using Platinum Nanoparticles Decorated Graphene/Poly-Cyclodextrin/Multiwalled Carbon Nanotubes (MWCNTs) Nanocomposite Based Biosensor. (americanelements.com)
  • It is related to the β- (beta) and γ- (gamma) cyclodextrins, which contain seven and eight glucose units, respectively. (wikipedia.org)
  • Depending on the size of the ring, a distinction is made between α-cyclodextrin with six, β-cyclodextrin with seven and γ-cyclodextrin with eight glucose units. (wacker.com)
  • In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. (pnas.org)
  • We have used a mouse model with a disrupted npc1 gene to study the effects of the cholesterol-mobilizing compound, 2-hydroxypropyl-beta-cyclodextrins (HPBCD), on the clinical course of this disorder. (nih.gov)
  • We have identified beta cyclodextrins (β-CDs), cyclic rings formed by 7 glucose residues, as small drugs that bind A2E. (arvojournals.org)
  • The most common cyclodextrins are alpha, beta and gamma cyclodextrins which have 6, 7 and 8 anhydroglucose units in their ring structure, respectively. (google.com)
  • Inclusion of a bridging ligand into cyclodextrin (CD), followed by the addition of Tb III leads to a polyrotaxane-type metallosupramolecular polymer (see figure, L=4,4′-biphenyldicarboxylic acid). (wiley.com)
  • Analyst, 2019, Advance Article DOI: 10.1039/C9AN00722A, PaperYongying Zhou, Jin Zhao, Shenghua Li, Minjie Guo, Zhi Fan A novel electrochemical sensor based on a cyclodextrin-decorated gold nanoparticle -mesoporous carbon hybrid was constructed for the detection ofp-nitrophenol. (medworm.com)
  • Horikoshi, K. and Nakamura, N. in Proceedings of the First International Symposium on Cyclodextrins (Szejtli, J.,ed. (springer.com)
  • Szejtli, J. (1998) Introduction and General Overview of Cyclodextrin Chemistry. (scirp.org)
  • The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) provides glycosylated paCDs (pGaCDs) that form transfectious nanocomplexes (glycoCDplexes) with pDNA. (csic.es)
  • 6. A process as claimed in claim 1 characterized in that the β-cyclodextrin to piroxicam molar ratio is comprised between 4:1 and 1:1. (freepatentsonline.com)
  • 8. A 1:2.5 piroxicam:β-cyclodextrin inclusion compound obtained by the process of claims 1 to 5, characterized by the Raman spectrum of FIG. 1. (freepatentsonline.com)
  • One such drug, piroxicam-β -cyclodextrin (PBC), has been used in Europe for 25 years. (eurekaselect.com)
  • Influence of processing variables on the solid-state of a model drug, piroxicam in cyclodextrin-based system and its effect on dissolution behavior of the drug was investigated in the present study. (omicsonline.org)
  • Binary systems containing piroxicam and hydroxypropyl-β -cyclodextrin prepared by various processes, were characterized by FTIR, thermal stability, photo stability and dissolution studies. (omicsonline.org)
  • Hydroxypropyl-β -cyclodextrin enhanced the solubility of piroxicam and increased dissolution rates from the binary systems. (omicsonline.org)
  • Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the U.S. FDA. (wikipedia.org)
  • Wacker Chemie AG uses dedicated enzymes, that can produce alpha-, beta- or gamma-cyclodextrin specifically. (wikipedia.org)
  • This is very valuable especially for the food industry, as only alpha- and gamma-cyclodextrin can be consumed without a daily intake limit. (wikipedia.org)
  • CycloChem and Wacker-Chemie are both gamma-cyclodextrin producers, with Wacker claiming to be the world's leading producer of cyclodextrin products, marketed under the Cavamax brand name. (nutraingredients-usa.com)
  • Lifton told this website that beta-cyclodextrin is allowed in Europe whereas gamma-cyclodextrin is currently forbidden in Europe. (nutraingredients.com)
  • This inclusion capability has led to an important use of cyclodextrins in luminescence spectroscopy. (bio-medicine.org)
  • The electronic structures of two kinds of cyclodextrin-carbon nanotube (αCD-CNT and γCD-CNT) composite films are investigated by using (angular dependent) photoelectron spectroscopy to gain insight as to why the αCD-CNT and γCD-CNT composite films show different performances in biosensor applications. (osti.gov)
  • Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy. (biomedsearch.com)
  • We've reached another historic milestone in our effort to treat Addi and Cassi with cyclodextrin! (addiandcassi.com)