Cyclitols: Cycloalkanes containing three or more hydroxyl groups on the ring atoms. Some polyhydroxypiperidines (PIPERIDINES) are called iminocyclitols or aza-sugars.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Alismatidae: A plant subclass of the class Liliopsida (monocotyledons) in the Chronquist classification system. This is equivalent to the Alismatales order in the APG classification system. It is a primitive group of more or less aquatic plants.Araceae: A plant family of the order Arales, subclass Arecidae, class Liliopsida (monocot). Many members contain OXALIC ACID and calcium oxalate (OXALATES).PortugalFossils: Remains, impressions, or traces of animals or plants of past geological times which have been preserved in the earth's crust.Oleaceae: A plant family of the order Lamiales. The leaves are usually opposite and the flowers usually have four sepals, four petals, two stamens, and two fused carpels that form a single superior ovary.MethylaminesBetaine: A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)Water-Electrolyte Balance: The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.Osmolar Concentration: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Desiccation: Removal of moisture from a substance (chemical, food, tissue, etc.).Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Zea mays: A plant species of the family POACEAE. It is a tall grass grown for its EDIBLE GRAIN, corn, used as food and animal FODDER.Ethnobotany: The study of plant lore and agricultural customs of a people. In the fields of ETHNOMEDICINE and ETHNOPHARMACOLOGY, the emphasis is on traditional medicine and the existence and medicinal uses of PLANTS and PLANT EXTRACTS and their constituents, both historically and in modern times.Dehydration: The condition that results from excessive loss of water from a living organism.Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Lipodystrophy: A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.Acacia: A plant genus of the family FABACEAE. The gums and tanning agents obtained from Acacia are called GUM ARABIC. The common name of catechu is more often used for Areca catechu (ARECA).Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Plant Somatic Embryogenesis Techniques: The process of embryo initiation in culture from vegetative, non-gametic, sporophytic, or somatic plant cells.Abscisic Acid: Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Osmotic Pressure: The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.TriterpenesAcidobacteria: A physiologically diverse phylum of acidophilic, gram-negative bacteria found in a wide variety of habitats, but particularly abundant in soils and sediments.Intramolecular Transferases: Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.Frankia: Genus of BACTERIA in the family Frankiaceae. They are nitrogen-fixing root-nodule symbionts of many species of woody dicotyledonous plants.Rhodopseudomonas: A genus of gram-negative, rod-shaped, phototrophic bacteria found in aquatic environments. Internal photosynthetic membranes are present as lamellae underlying the cytoplasmic membrane.Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Astragalus Plant: A plant genus in the family FABACEAE, subfamily Papilionaceae, order Fabales, subclass Rosidae. Many of the species are associated with poisoning of grazing animals. Some of the species are used medicinally.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Hordeum: A plant genus of the family POACEAE. The EDIBLE GRAIN, barley, is widely used as food.Behavior Therapy: The application of modern theories of learning and conditioning in the treatment of behavior disorders.Murinae: A subfamily in the family MURIDAE, comprising the Old World MICE and RATS.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Panicum: A plant genus of the family POACEAE. The seed is one of the EDIBLE GRAINS used in millet cereals and in feed for birds and livestock (ANIMAL FEED). It contains diosgenin (SAPONINS).Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)Ecotype: Geographic variety, population, or race, within a species, that is genetically adapted to a particular habitat. An ecotype typically exhibits phenotypic differences but is capable of interbreeding with other ecotypes.Biofuels: Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).Poaceae: A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.Liriodendron: A plant genus of the family MAGNOLIACEAE. Members include hardwood trees of eastern North America with distinct large tuliplike flowers.Aporphines: Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).Polygonum: A plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE).Trametes: A genus of fungi in the family Coriolaceae.Drimys: A plant genus of the family WINTERACEAE. They have leathery, elliptic-shaped leaves; red-tinged shoots; and jasmine-scented, cream-colored, 8- to 12-petaled, 2.5-centimeter (1-inch) flowers in clusters.

The preparation of new phosphorus-centered functional groups for modified oligonucleotides and other natural phosphates. (1/10)

Efforts to develop synthetic methodologies allowing the preparation of alpha,alpha- difluorophosphonothioates, alpha,alpha-difluorophosphonodithioates, alpha,alpha-difluorophosphono- trithioates, and alpha,alpha-difluorophosphinates are reviewed in the light of applications in the field of modified oligonucleotides and cyclitol phosphates. Two successful approaches have been developed, based either on the addition of phosphorus-centered radicals onto gem-difluoroalkenes or on a process involving the addition of lithiodifluorophosphono- thioates 91 onto a ketone and the subsequent deoxygenation reaction of the adduct. The radical route successfully developed a practical route to alpha,alpha-difluoro-H-phosphinates which proved to be useful intermediates to a variety of phosphate isosters. The ionic route led to the first preparation of phosphonodifluoromethyl analogues of nucleoside- 3'-phosphates.  (+info)

Hypoglycemic effect of 13-membered ring thiocyclitol, a novel alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata). (2/10)

A novel 13-membered ring thiocyclitol, isolated from an aqueous extract of Kothala-himbutu (Salacia reticulata), inhibited alpha-glucosidase in vitro. The inhibitory activity was investigated by maltose- and sucrose-loading on Wistar rats. This study found significant lowering of postprandial glucose levels, and the potency of 13-membered ring thiocyclitol was confirmed in vivo.  (+info)

Progress in aminocyclitol biosynthesis. (3/10)

 (+info)

Concise synthesis of iminocyclitols via Petasis-type aminocyclization. (4/10)

 (+info)

Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring. (5/10)

 (+info)

Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388. (6/10)

 (+info)

Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. (7/10)

 (+info)

Regioselectivity in the ring opening of epoxides for the synthesis of aminocyclitols from D-(-)-quinic acid. (8/10)

 (+info)

*Cyclitol

Cyclitols are one of the compatible solutes which are formed in a plant as a response to salt or water stress. Some cyclitol (e ... Nomenclature of Cyclitols on chem.qmul.ac.uk List of cyclitol molecules on chemicalland21.com. ... Cyclitols are cycloalkanes containing a hydroxyl group on each of three or more ring atoms. They are cyclic polyols. ...

*Aminocyclitol

"Biosynthesis of the C7-cyclitol Moiety of Acarbose inActinoplanes Species SE50/110 7-O-PHOSPHORYLATION OF THE INITIAL CYCLITOL ... In validamycin biosynthesis, the C-N linkage which connect the C7 cyclitol moiety to the other was found to be formed by ... The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are ... "Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18". The Journal of Antibiotics. 55 (6): ...

*Inositol 1-methyltransferase

Wagner I, Hofmann H, Hoffmann-Ostenhof O (1969). "[Biosynthesis of cyclitols. 23. A soluble enzyme from pea seedlings ...

*Inositol 3-methyltransferase

Hofmann H, Wagner I, Hoffmann-Ostenhof O (1969). "[Biosynthesis of cyclitols. XXIV. A soluble enzyme from Vinca rosea ...

*Conduritol

They are therefore cyclic polyols or cyclitols. The compounds in this group exhibit cis-trans isomerism, with six isomers that ...

*Ciceritol

... is a cyclitol. It is a pinitol digalactoside that can be isolated from seeds of chickpea, lentil and white lupin. ...

*Pinpollitol

... is a cyclitol. It is a di-O-methyl-(+)-chiro-inositol that can be isolated from Pinus radiata. Gallagher, R (1975 ...

*Viscumitol

... is a cyclitol. It is a dimethyl-ether of muco-inositol that can be isolated from Viscum album. Richter, Andreas ( ...

*Ononitol

... is a cyclitol. It is a 4-O-methyl-myo-inositol and is a constituent of Medicago sativa. E. A. McComb and V. V. Rendig ...

*Bornesitol

... is a cyclitol. It can be found in the gentianaceae and menyanthaceae plant families. Chemically, it is a methyl ...

*5-Deoxyinositol

... (quercitol) is a cyclitol. It can be found in wines aged in oak wood barrels. It can also be found in Quercus ... "Analysis of cyclitols in different Quercus species by gas chromatography-mass spectrometry". Journal of the Science of Food and ...

*Pinitol

... is a cyclitol, a cyclic polyol. It is a known anti-diabetic agent isolated from Sutherlandia frutescens leaves. Gall ... A cyclitol derivative can be found in the marine sponge Petrosia sp. Narayanan, 1987 Introduction Sutherlandia frutescens - ... Pages 1745-1751 A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp. Kim D.-K.; Young Ja Lim; ...

*Quebrachitol

... is a naturally occurring optically active cyclitol, a cyclic polyol. It can be found in Allophylus edulis and in ...

*Allophylus edulis

Quebrachitol is a cyclitol, a cyclic polyol found in A. edulis. This plant has several different common names in Portuguese: ...

*Ralph L. Obendorf

He has studied cell wall polysaccharides and the role of sugars, cyclitols and methanol in seed deterioration and germplasm ... Dependence on flatulence-producing oligosaccharides and cyclitols-review and survey". Seed Science Research. 4: 385-405. doi: ... research on the biology of seeds included characterizing the molecular structure and synthesis of galactosyl cyclitols; ...

*Valienol

... (streptol) is a C-7 cyclitol similar in structure to valienamine. Petr Sedmera; Petr Halada & Stanislav Pospisil (2009 ...

*Marsdenia cundurango

... is known to contain conduritol, a cyclitol or cyclic polyol. It was first isolated in 1908 by K. Kübler ...

*Streptomyces lincolnensis

It also produces valienol, a C-7 cyclitol similar in structure to valienamine. The name of the species is derived from Lincoln ...

*Valienamine

June 2002). "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the ... initial cyclitol precursor leads to proposal of a new biosynthetic pathway". J. Biol. Chem. 277 (25): 22853-62. doi:10.1074/jbc ...

*Aspidosperma quebracho-blanco

Quebrachitol is a cyclitol, a cyclic polyol found in the bark of A. quebracho. 'Pendula' - with weeping branches. Trees portal ...

*Rubber tapping

... a cyclitol or cyclic polyol. In information technology the term 'Rubber tapping' is sometimes used as a lampoon for planned ...

*Martin Banwell

March 2005). "Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding ...

*A value

Huang, C.-Y.; Cabell, L.A.; Anslyn, E.V. (1994). "Molecular Recognition of Cyclitols by Neutral Polyaza-Hydrogen-Bonding ...

*Shikimic acid

... , more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid ...

*Hydrolysable tannin

At the center of a hydrolyzable tannin molecule, there is a carbohydrate (usually D-glucose but also cyclitols like quinic or ...
Khaw, L.E., Bohm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (1998). „Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase". J. Bacteriol. 180: 809-814. PMID 9473033 ...
3VDN: Crystal Structure of the VldE, the pseudo-glycosyltransferase, which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis
Export Data And Price Of Salacia Reticulata , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of Salacia Reticulata Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India Salacia Reticulata Export data. You can find previous two days Salacia Reticulata Export data on Eximpulse Services. Salacia Reticulata Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for Salacia Reticulata Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected] Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian companies and Foreign ...
Salacia Oblonga / Salacia Reticulata , Find Complete Details about Salacia Oblonga / Salacia Reticulata,Salacia Diabetes from Slimming Tea Supplier or Manufacturer-H.BILAL & CO
Pancratistatin has been selected for pre-clinical development but is sparingly soluble in water. A disodium phosphate derivative has been synthesized which is water soluble and is bioequivalent thereof. The critical step in the synthesis of the phenolic phosphate was phosphorylation of 1,2,3,4-tetraacetoxy-pancratistatin with dibenzyloxy(N,N-diisopropylamido)phosphine. This pancratistatin prodrug has the structure set forth below: ##STR1##
TY - JOUR. T1 - Orally administered Salacia reticulata extract reduces H1N1 influenza clinical symptoms in murine lung tissues putatively due to enhanced natural killer cell activity. AU - Romero-Pérez, Gustavo A.. AU - Egashira, Masayo. AU - Harada, Yuri. AU - Tsuruta, Takeshi. AU - Oda, Yuriko. AU - Ueda, Fumitaka. AU - Tsukahara, Takamitsu. AU - Tsukamoto, Yasuhiro. AU - Inoue, Ryo. PY - 2016/3/31. Y1 - 2016/3/31. N2 - Influenza is a major cause of respiratory tract infection. Although most cases do not require further hospitalization, influenza periodically causes epidemics in humans that can potentially infect and kill millions of people. To countermeasure this threat, new vaccines need to be developed annually to match emerging influenza viral strains with increased resistance to existing vaccines. Thus, there is a need for finding and developing new anti-influenza viral agents as alternatives to current treatments. Here, we tested the antiviral effects of an extract from the stems and ...
One of the biggest hurdles in the fight against cancer is the non‐selective nature of most current treatments. On the other hand, opioids‐refractive cancer pain is a most important unsolved problem. Consequently, the search and development of new drugs that are tumor‐killing (while non‐cytotoxic to normal cells) and/or potent analgesics are major goals in cancer research. In this context, pancratistatin and tetrodotoxin, the most prominent representatives of two different families of natural products, have been identified as highly promising leads for cancer treatment and cancer pain, respectively; in fact, they are currently at the focus of some initiatives for pharmaceutical development.. Interest in pancratistatin stems from its high level of in vitro and in vivo cell growth inhibitory activity on a wide variety of human cancer cell lines, but particularly from its mode of action that, while yet unknown, is very selective: pancratistatin does not affect normal cells in clear contrast ...
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway ...
Sztaricskai, Ferenc and Batta, Gyula and Boda, Zoltán and Gunda, Tamás and Herczegh, Pál and Kobzos, Tibor and Lekli, István and Pelyvás Ferenczik, István and Sum, Anita and Tamaskó, Éva (2009) Glikopeptid és ciklitol antibiotikumok szintetikus módosítása, biológiai vizsgálata = Synthetic modification and biological investigation of glycopeptide and cyclitol antibiotics. Project Report. OTKA. ...
To study the cost of chromosomal drug resistance mutations to bacteria, we investigated the fitness cost of mutations that confer resistance to different classes of antibiotics affecting bacterial protein synthesis (aminocyclitols, 2-deoxystreptamines, macrolides). We used a model system based on an in vitro competition assay with defined Mycobacterium smegmatis laboratory mutants; selected mutations were introduced by genetic techniques to address the possibility that compensatory mutations ameliorate the resistance cost. We found that the chromosomal drug resistance mutations studied often had only a small fitness cost; compensatory mutations were not involved in low-cost or no-cost resistance mutations. When drug resistance mutations found in clinical isolates were considered, selection of those mutations that have little or no fitness cost in the in vitro competition assay seems to occur. These results argue against expectations that link decreased levels of antibiotic consumption with the ...
It comprises the use of D-fagomine or derivatives thereof in the prevention and/or coadjuvant treatment of bacterial infections, as well as to pharmaceutical, veterinary, or food and feed, pet food compositions containing them.
Boda, Zoltán (2016) Teendők súlyos vérzés vagy sürgős sebészeti beavatkozás esetén direkt orális antikoaguláns gyógyszerrel kezeltekben. Az új dabigatran-antidótum: idarucizumab helye a klinikai gyakorlatban. Orvosi Hetilap, 157 (12). pp. 443-450. ISSN 0030-6002 Sztaricskai, Ferenc and Batta, Gyula and Boda, Zoltán and Gunda, Tamás and Herczegh, Pál and Kobzos, Tibor and Lekli, István and Pelyvás Ferenczik, István and Sum, Anita and Tamaskó, Éva (2009) Glikopeptid és ciklitol antibiotikumok szintetikus módosítása, biológiai vizsgálata = Synthetic modification and biological investigation of glycopeptide and cyclitol antibiotics. Project Report. OTKA. Muszbek, László and Bagoly, Zsuzsa and Bereczky, Zsuzsanna and Boda, Zoltán and Fazakas, Ferenc and Hársfalvi, Jolán and Hevessy, Zsuzsa and Katona, Éva and Kiss, Csongor and Komáromi, István and Losonczy, Gergely and Pfliegler, György and Schlammadinger, Ágota and Tóth, Judit and Varga, Sándor (2009) Ritka ...
Alkaloids pancratistatin and narciclasine, isolated from Amaryllidaceae, have been shown to present antitumor activity on preclinical models, including melanoma. Despite extensive investigations, pancratistatin or narciclasine analogues did not succeed to provide sufficient therapeutic benefit, [1] mostly hampered by poor water solubility and systemic toxicity [1]. To overcome those limitations, we developed a chemistry program aimed at improving both their physicochemical and pharmacological properties. A literature survey suggests that any structural modification of this highly oxigenated isocarbostiryl specific scaffold would lead to a loss of activity except on position 1, difficult to achieve but interesting to explore.. A series of 40 novel 1-aminopancratistatin derivatives was synthesised starting from large quantities of narciclasine extracted from Narcissus bulbs. These novel compounds exhibit an improved pharmaceutical profile facing standard solubility, plasmatic and microsomal ...
1. A method for preventing HIV-mediated cognitive decline and HIV dementia, the method comprising administering to a subject infected with HIV a therapeutically effective amount of at least one compound of any of formulas (I) to (VIII), a pharmaceutically salt thereof, or combination thereof: ##STR00019## each X is independently selected from H, CH, or halogen (preferably the halogen is F), and n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 a six membered ring is defined and if n=5 a seven membered ring is defined, where carbons of the ring may include --CH or --CH2 and wherein the carbons of the ring optionally can be substituted with halogen or alkyl having 1 to 3 carbons ##STR00020## where X is O, NH, S, or CH2, and Y is O, NH, S, or CH2; ##STR00021## n=1 to 5, wherein if n=1 a three membered ring is defined, if n=2 a four membered ring is defined, if n=3 a five membered ring is defined, if n=4 ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Coloured scanning electron micrograph (SEM) of Streptomyces hygroscopicus, Gram-positive, aerobic, filamentous, biofilm-forming, rod prokaryote (bacterium). Streptomyces sp. belong to the Actinomycetes group and are bacteria that share many characteristics with the fungi. They grow usually as filaments (chains of cells) and often branch to form a network of filaments (mycelium) in the soil. These soil bacteria are responsible for the musty odour of soil. This strain of Streptomyces hygroscopicus produces the antibiotic, milbemycin, which is used as an insecticide and also to control certain parasitic infections in animals. It is also a biofilm forming bacterium. Biofilms are primarily accumulations of bacteria in aqueous environments. They form when bacteria secrete slimy, mucilaginous materials that provide the microorganisms with a means of attachment to moist surfaces. Magnification: x1,600 when shortest axis printed at 25 - Stock Image C032/2295
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
12. Salacia Linnaeus, Mant. Pl. 2: 159. 1771. 五层龙属 wu ceng long shu Authors: Hua Peng & Michele Funston Courondi Adanson.. Climbing or scrambling shrubs or small trees, glabrous or glabrescent; branchlets subterete, internode usually dilated or slightly flat. Leaves opposite to subopposite, rarely alternate, entire, crenate, or serrate, estipulate. Inflorescences axillary or cauliflorous, thyrsoid, cymose, or fasciculate. Flowers bisexual, 5-merous. Disk fleshy, pulvinate or cupular, entire or lobed, extrastaminal. Stamens (2 or)3; anthers longitudinally, obliquely, or transversely dehiscent, extrorse or apical. Ovary (2 or)3-locular, whole or mostly concealed in disk; ovules axile, 2-9 per locule. Berry spheroid, fleshy or subligneous. Seeds 2-12, angular, exalbuminous, surrounded by mucilaginous arils.. About 200 species: chiefly in tropical regions; ten species (eight endemic) in China.. ...
... is pseudo-oligosaccharide with a terminal C7-cyclitol patented in 1975 by Bayer. Acarbose is a component of the amylostatin complex produced by species of Actinoplanes and Streptomyces. Acarbose acts as a potent inhibitor of α-glucosidases and saccharases. Since 1990, acarbose has been used therapeutically for the treatment of type 2 diabetes ...
For many years, the primary method of global drug discovery has involved the synthesis of naturally occurring molecules and their derivatives. This drug discovery process would involve several steps, from initial extraction and isolation from a biological host, the molecule would then have to be cha...
... is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumor cells ...
You overlooked the strain from the sp2 carbon in a small ring. The ring strain you have listed is based on sp3 carbon. sp2 supposed to have a planar triangular geometry (120°, compared to 109° for sp3) and will be more strained in a 3 or 4 membered ring. 6 membered ring will be best followed by 5 membered ring.. Also, you have discussed a lot about the stability of carboncations. Acid catalyzed elimination/rearrangement reaction is a thermodynamic condition. The stability of product is more important than the stability of intermediate.. ...
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
The patent is a divisional of the application that issued as U.S. Patent No. 7,947,312. There are 16 claims directed to a method of enhancing immune competency, treating disorders associated with the immune system, inhibiting inflammatory response, treating disorders associated with inflammatory response, enhancing anti-tumor response, and treating disorders associated with response to tumor formation and growth in mammals by administering an isolated bioactive component identified as a quinic acid analog (quinic acid lactone), whether as free acid or as a quinic acid salt, including quinic acid ammonium salt. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
There are several distinct two-dimensional zeolite building layers that can condense through different stacking arrangements of the layers to form various three-dimensional framework materials. All known building layers are dense layers in that they do not contain 8-membered ring (MR) or larger pores perpendicular to the two-dimensional layers. Herein, we report a new material (CIT-10) that consists of a two-dimensional layer (termed

Molecules | Free Full-Text | Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipiferaMolecules | Free Full-Text | Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera

These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)- ... These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)- ...
more infohttp://www.mdpi.com/1420-3049/19/4/4234/xml

Cyclitol - WikipediaCyclitol - Wikipedia

Cyclitols are one of the compatible solutes which are formed in a plant as a response to salt or water stress. Some cyclitol (e ... Nomenclature of Cyclitols on chem.qmul.ac.uk List of cyclitol molecules on chemicalland21.com. ... Cyclitols are cycloalkanes containing a hydroxyl group on each of three or more ring atoms. They are cyclic polyols. ...
more infohttps://en.wikipedia.org/wiki/Cyclitol

PDF] Effect of Lupin Cyclitols on Pea Aphid Probing Behaviour - Semantic ScholarPDF] Effect of Lupin Cyclitols on Pea Aphid Probing Behaviour - Semantic Scholar

In aphid bodies, both cyclitols were traced, respectively, to the host plant treat- ment. The new cyclitols in pea tissues did ... This may reflect difficulties in the uptake of the phloem sap, and point to lupin cyclitols as being responsible, at least in ... However, the aphid behaviour on cyclitol-treated plants as compared to their behaviour on the control was slightly altered. Non ... Feeding of peas with cyclitols at a concentration of 10 mM, caused a selective accumulation of d-pinitol and d-chiro-inositol ...
more infohttps://www.semanticscholar.org/paper/Effect-of-Lupin-Cyclitols-on-Pea-Aphid-Probing-Kordan-Lahuta/59ec7783085d7a0b44e223ce0bce113b0fe88fab

Aminocyclitol - WikipediaAminocyclitol - Wikipedia

"Biosynthesis of the C7-cyclitol Moiety of Acarbose inActinoplanes Species SE50/110 7-O-PHOSPHORYLATION OF THE INITIAL CYCLITOL ... In validamycin biosynthesis, the C-N linkage which connect the C7 cyclitol moiety to the other was found to be formed by ... The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are ... "Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18". The Journal of Antibiotics. 55 (6): ...
more infohttps://en.wikipedia.org/wiki/Aminocyclitol

Inositol: Uses, Side Effects, Interactions, Dosage, and WarningInositol: Uses, Side Effects, Interactions, Dosage, and Warning

Nomenclature of Cyclitols. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC) and IUPAC-IUB Commission on ... Biochemical Nomenclature (CBN). Available at: http://www.chem.qmw.ac.uk/iupac/cyclitol/ (Accessed 23 January 2004). ...
more infohttps://www.webmd.com/vitamins/ai/ingredientmono-299/inositol

AlismatalesAlismatales

Plant sympodial - Thalassodendron), stems erect; (roots branched), (root hairs 0); distinctive cyclitols; rhizome with two or a ... Additional information is taken from Kuo and McComb (1989, 1998: general); for cyclitols, see Drew (1983) and for floral ...
more infohttp://www.mobot.org/mobot/research/apweb/orders/Alismatalesweb.htm

Leiv K. Sydnes | University of BergenLeiv K. Sydnes | University of Bergen

Sydnes, Leiv K.; Hudlicky, T.; Cebulak, M. 1994. Cyclitols and Their Derivatives. (Bokomtale). Kjemi. 53: 28. ...
more infohttps://www.uib.no/en/persons/Leiv.Sydnes

The Biosynthesis of Polysaccharides | SpringerLinkThe Biosynthesis of Polysaccharides | SpringerLink

For many years studies of the structure and biosynthesis of saccharides formed a specialised and somewhat abstruse part of biochemistry, with little or no place in molecular biology. In recent years t
more infohttps://link.springer.com/book/10.1007%2F978-1-4615-9873-2

UDP-6-sulfoquinovose (CHEBI:15855)UDP-6-sulfoquinovose (CHEBI:15855)

Cyclitols are generally not regarded as carbohydrates.. nucleotide Definition : A nucleotide is a nucleoside phosphate ...
more infohttps://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:15855

Frontiers | Proteomics, metabolomics, and ionomics perspectives of salinity tolerance in halophytes | Plant ScienceFrontiers | Proteomics, metabolomics, and ionomics perspectives of salinity tolerance in halophytes | Plant Science

Orthen, B., Popp, M., and Smirnoff, N. (1994). Hydroxyl radical scavenging properties of cyclitols. Proc. R. Soc. Edinb. Sec. B ... Loewus, F. A., and Dickinson, D. B. (1982). "Cyclitols," in Encyclopedia of Plant Physiology: Plant Carbohydrates 1. ...
more infohttps://www.frontiersin.org/articles/10.3389/fpls.2015.00537/full

Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses | Journal of...Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses | Journal of...

For example, it has been found that cyclitols (cyclic polyols; Fig. 2) and polyols such as mannitol, which are used by many ... Orthen, B., Popp, M. and Smirnoff, N. (1994). Hydroxyl radical scavenging properties of cyclitols. Proc. R. Soc. Edinburgh Sect ...
more infohttp://jeb.biologists.org/content/208/15/2819

Academy of Europe: Areas of ActivityAcademy of Europe: Areas of Activity

Carbohydrates and cyclitols Go to *Carbon dioxide Capture and Storage Go to ...
more infohttps://acadeuro.org/ae/Acad_Main/Sections/Chemical_sciences/Areas_of_Activity

Preamble, 2-Carb-0 & 2-Carb-1Preamble, 2-Carb-0 & 2-Carb-1

Nomenclature of cyclitols, 1973 [8]. Numbering of atoms in myo-inositol, 1988 [9]. Symbols for specifying the conformation of ... Cyclitols are generally not regarded as carbohydrates. Their nomenclature is dealt with in other recommendations [8,9].. 2-Carb ... 8. IUPAC-IUB Commission on Biochemical Nomenclature (CBN), Nomenclature of cyclitols (Recommendations 1973), Biochem. J., 153, ...
more infohttps://www.qmul.ac.uk/sbcs/iupac/2carb/00n01.html

A Role for Sorbitol in Desiccation Tolerance of Developing Maize Kernels: Inference from the Properties of Maize Sorbitol...A Role for Sorbitol in Desiccation Tolerance of Developing Maize Kernels: Inference from the Properties of Maize Sorbitol...

Loewus FA (1990) Cyclitols. In PM Dey, JB Harborne, eds. Methods in Plant Biochemistry, Vol. 2, Academic Press, Inc., New York ...
more infohttps://rd.springer.com/chapter/10.1007/978-3-642-79133-8_22

Mutasynthesis and Directed Biosynthesis for the Production of New Antibiotics | SpringerLinkMutasynthesis and Directed Biosynthesis for the Production of New Antibiotics | SpringerLink

II Conversion of non-amino containing cyclitols to aminoglycoside antibiotics. J. Antibiot. 30: 90-105.CrossRefGoogle Scholar ... In Amino-cyclitol antibiotics (Rinehart, K. L., Jr. and T. Suami Eds.), ACS Symposium Series No. 125. American Chemical Society ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-4460-5_16

Adipose Tissue as a Target of HIV-1 Antiretroviral Drugs. Potential Consequences on Metabolic Regulations | Bentham ScienceAdipose Tissue as a Target of HIV-1 Antiretroviral Drugs. Potential Consequences on Metabolic Regulations | Bentham Science

Title: Adipose Tissue as a Target of HIV-1 Antiretroviral Drugs. Potential Consequences on Metabolic Regulations. VOLUME: 16 ISSUE: 30. Author(s):Martine Caron-Debarle, Franck Boccara, Claire Lagathu, Benedicte Antoine, Pascale Cervera, Jean-Philippe Bastard, Corinne Vigouroux and Jacqueline Capeau. Affiliation:INSERM, UMRS_938, CDR Saint-Antoine, 75012 Paris, France.. Keywords:Lipoatrophy, lipohypertrophy, nucleoside analogue reverse transcriptase inhibitors, protease inhibitors, insulin resistance, inflammation, mitochondrial dysfunction, cardio-metabolic risk. Abstract: Adipose tissue redistribution occurred at first in HIV-infected patients about 15 years ago after initiation of combination antiretroviral treatment (ART) and the responsibility of drugs was rapidly considered. This lipodystrophic syndrome can associate lipoatrophy, affecting subcutaneous adipose tissue in priority with fat hypertrophy, in particular in the upper part of the body, and metabolic alterations, dyslipidemia and ...
more infohttp://www.eurekaselect.com/72875/article/adipose-tissue-target-hiv-1-antiretroviral-drugs-potential-consequences-metabolic?tracking-code=4

Patent US5036007 - Method for reproducing coniferous plants by somatic embryogenesis using ... - Google PatentsPatent US5036007 - Method for reproducing coniferous plants by somatic embryogenesis using ... - Google Patents

The cyclitols are normally six carbon ring compounds that are hexahydroxylated. The most readily available cyclitol is myo- ...
more infohttp://www.google.com/patents/US5036007?dq=5527183

Frontiers | Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in...Frontiers | Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in...

Acarbose is a cyclitol-containing aminoglycoside. The biosynthesis genes are encoded by the acb gene cluster, which was ... The AcbC protein from Actinoplanes Species Is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2019.02448/full

EC 1.1.1.1 to EC 1.1.1.50EC 1.1.1.1 to EC 1.1.1.50

The numbering system used for the 3-dehydroquinate is that of the recommendations on cyclitols, sections I-8 and I-9: and is ...
more infohttps://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC1/0101a.html

Human Metabolome Database: Showing metabocard for PIP2(20:2(11Z,14Z)/18:0) (HMDB0010120)Human Metabolome Database: Showing metabocard for PIP2(20:2(11Z,14Z)/18:0) (HMDB0010120)

Cyclitol or derivatives. *Dicarboxylic acid or derivatives. *Organic phosphoric acid derivative. *Phosphoric acid ester ...
more infohttp://www.hmdb.ca/metabolites/HMDB0010120

Human Metabolome Database: Showing metabocard for PIP3(18:0/18:1(11Z)) (HMDB0010152)Human Metabolome Database: Showing metabocard for PIP3(18:0/18:1(11Z)) (HMDB0010152)

Cyclitol or derivatives. *Dicarboxylic acid or derivatives. *Fatty acyl. *Alkyl phosphate. *Phosphoric acid ester ...
more infohttp://www.hmdb.ca/metabolites/HMDB0010152

FabalesFabales

in seeds, 5-deoxyflavonoids, C-glycosylflavonoids, pinitol [cyclitol] +; cork also in outer cortex; (wood storied); secretory ...
more infohttp://www.mobot.org/MOBOT/research/APweb/orders/Fabalesweb.htm

Academy of Europe: Areas of ActivityAcademy of Europe: Areas of Activity

Carbohydrates and cyclitols Go to *Carbon dioxide Capture and Storage Go to ...
more infohttps://www.ae-info.org/ae/Acad_Main/Sections/Chemical_sciences/Areas_of_Activity
  • In validamycin biosynthesis, the C-N linkage which connect the C7 cyclitol moiety to the other was found to be formed by unprecedented actions of nucleotidyltransferase and glycosyltransferase-like enzymes (which is termed pseudoglycosyltransferase). (wikipedia.org)
  • Cyclitols are cycloalkanes containing a hydroxyl group on each of three or more ring atoms. (wikipedia.org)
  • According to the news reporters, the research concluded: "Targeted disruption of the gene encoding the N-glycosyltransferase, prlH, abolished pyralomicin production, and recombinant expression of PrlA confirms the activity of this enzyme as a sugar phosphate cyclase involved in the formation of the C7-cyclitol moiety. (equities.com)
  • To determine whether increasing the supply of free cyclitols to immature embryos of these lines results in increased accumulation of galactosyl cyclitols, isolated immature embryos free of maternal tissues were fed solutions containing either d - chiro -inositol, myo -inositol or d -pinitol, or a control solution without cyclitols, for 24 h. (cambridge.org)
  • In recent years research has focused on explaining the molecular basis of value in use of legume seeds with special emphasis on the role of raffinose family oligosacharides and galactosyl cyclitols. (olsztyn.pl)
  • Compounds containing a quinic acid moiety (or a derivative thereof), which is a cyclitol made up of a cyclohexane ring that bears four hydroxyl groups at positions 1,3.4, and 5, as well as a carboxylic acid at position 1. (wishartlab.com)
  • These are compounds containing a quinic acid moiety (or a derivative thereof), which is a cyclitol made up of a cyclohexane ring that bears four hydroxyl groups at positions 1,3.4, and 5, as well as a carboxylic acid at position 1. (wishartlab.com)