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A publication issued at stated, more or less regular, intervals.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE.
A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Those individuals engaged in research.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.
The functional hereditary units of FUNGI.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Deoxyribonucleic acid that makes up the genetic material of fungi.

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p. (1/296)

In Saccharomyces cerevisiae, mating pheromones activate two MAP kinases (MAPKs), Fus3p and Kss1p, to induce G1 arrest prior to mating. Fus3p is known to promote G1 arrest by activating Far1p, which inhibits three Clnp/Cdc28p kinases. To analyze the contribution of Fus3p and Kss1p to G1 arrest that is independent of Far1p, we constructed far1 CLN strains that undergo G1 arrest from increased activation of the mating MAP kinase pathway. We find that Fus3p and Kss1p both control G1 arrest through multiple functions that operate in parallel with Far1p. Fus3p and Kss1p together promote G1 arrest by repressing transcription of G1/S cyclin genes (CLN1, CLN2, CLB5) by a mechanism that blocks their activation by Cln3p/Cdc28p kinase. In addition, Fus3p and Kss1p counteract G1 arrest through overlapping and distinct functions. Fus3p and Kss1p together increase the expression of CLN3 and PCL2 genes that promote budding, and Kss1p inhibits the MAP kinase cascade. Strikingly, Fus3p promotes proliferation by a novel function that is not linked to reduced Ste12p activity or increased levels of Cln2p/Cdc28p kinase. Genetic analysis suggests that Fus3p promotes proliferation through activation of Mcm1p transcription factor that upregulates numerous genes in G1 phase. Thus, Fus3p and Kss1p control G1 arrest through a balance of arrest functions that inhibit the Cdc28p machinery and proliferative functions that bypass this inhibition.  (+info)

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity. (2/296)

We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) for crystallization using the CDK-activating kinase 1 (CAK1) from Saccharomyces cerevisiae and have grown crystals using microseeding techniques. Phosphorylation of monomeric human CDK2 by CAK1 is more efficient than phosphorylation of the binary CDK2-cyclin A complex. Phosphorylated CDK2 exhibits histone H1 kinase activity corresponding to approximately 0.3% of that observed with the fully activated phosphorylated CDK2-cyclin A complex. Fluorescence measurements have shown that Thr160 phosphorylation increases the affinity of CDK2 for both histone substrate and ATP and decreases its affinity for ADP. By contrast, phosphorylation of CDK2 has a negligible effect on the affinity for cyclin A. The crystal structures of the ATP-bound forms of phosphorylated CDK2 and unphosphorylated CDK2 have been solved at 2.1-A resolution. The structures are similar, with the major difference occurring in the activation segment, which is disordered in phosphorylated CDK2. The greater mobility of the activation segment in phosphorylated CDK2 and the absence of spontaneous crystallization suggest that phosphorylated CDK2 may adopt several different mobile states. The majority of these states are likely to correspond to inactive conformations, but a small fraction of phosphorylated CDK2 may be in an active conformation and hence explain the basal activity observed.  (+info)

A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. (3/296)

Oriented cell growth requires the specification of a site for polarized growth and subsequent orientation of the cytoskeleton towards this site. During mating, haploid Saccharomyces cerevisiae cells orient their growth in response to a pheromone gradient overriding an internal landmark for polarized growth, the bud site. This response requires Cdc24p, Far1p, and a heterotrimeric G-protein. Here we show that a two- hybrid interaction between Cdc24p and Gbeta requires Far1p but not pheromone-dependent MAP-kinase signaling, indicating Far1p has a role in regulating the association of Cdc24p and Gbeta. Binding experiments demonstrate that Cdc24p, Far1p, and Gbeta form a complex in which pairwise interactions can occur in the absence of the third protein. Cdc24p localizes to sites of polarized growth suggesting that this complex is localized. In the absence of CDC24-FAR1-mediated chemotropism, a bud site selection protein, Bud1p/Rsr1p, is essential for morphological changes in response to pheromone. These results suggest that formation of a Cdc24p-Far1p-Gbetagamma complex functions as a landmark for orientation of the cytoskeleton during growth towards an external signal.  (+info)

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. (4/296)

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins. The yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCFCdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition. These findings provide a further link between VHL and the cellular ubiquitination machinery.  (+info)

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. (5/296)

Exit from mitosis in budding yeast requires a group of essential proteins--including the GTPase Tem1 and the protein phosphatase Cdc14--that downregulate cyclin-dependent kinase activity. We identified a mutation, net1-1, that bypasses the lethality of tem1 delta. NET1 encodes a novel protein, and mass spectrometric analysis reveals that it is a key component of a multifunctional complex, denoted RENT (for regulator of nucleolar silencing and telophase), that also contains Cdc14 and the silencing regulator Sir2. From G1 through anaphase, RENT localizes to the nucleolus, and Cdc14 activity is inhibited by Net1. In late anaphase, Cdc14 dissociates from RENT, disperses throughout the cell in a Tem1-dependent manner, and ultimately triggers mitotic exit. Nucleolar sequestration may be a general mechanism for the regulation of diverse biological processes.  (+info)

Cdc4, a protein required for the onset of S phase, serves an essential function during G(2)/M transition in Saccharomyces cerevisiae. (6/296)

Saccharomyces cerevisiae proteins Cdc4 and Cdc20 contain WD40 repeats and participate in proteolytic processes. However, they are thought to act at two different stages of the cell cycle: Cdc4 is involved in the proteolysis of the Cdk inhibitor, Sic1, necessary for G(1)/S transition, while Cdc20 mediates anaphase-promoting complex-dependent degradation of anaphase inhibitor Pds1, a process necessary for the onset of chromosome segregation. We have isolated three mutant alleles of CDC4 (cdc4-10, cdc4-11, and cdc4-16) which suppress the nuclear division defect of cdc20-1 cells. However, the previously characterized mutation cdc4-1 and a new allele, cdc4-12, do not alleviate the defect of cdc20-1 cells. This genetic interaction suggests an additional role for Cdc4 in G(2)/M. Reexamination of the cdc4-1 mutant revealed that, in addition to being defective in the onset of S phase, it is also defective in G(2)/M transition when released from hydroxyurea-induced S-phase arrest. A second function for CDC4 in late S or G(2) phase was further confirmed by the observation that cells lacking the CDC4 gene are arrested both at G(1)/S and at G(2)/M. We subsequently isolated additional temperature-sensitive mutations in the CDC4 gene (such as cdc4-12) that render the mutant defective in both G(1)/S and G(2)/M transitions at the restrictive temperature. While the G(1)/S block in both cdc4-12 and cdc4Delta mutants is abolished by the deletion of the SIC1 gene (causing the mutants to be arrested predominantly in G(2)/M), the preanaphase arrest in the cdc4-12 mutant is relieved by the deletion of PDS1. Collectively, these observations suggest that, in addition to its involvement in the initiation of S phase, Cdc4 may also be required for the onset of anaphase.  (+info)

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. (7/296)

The separation of sister chromatids in anaphase is followed by spindle disassembly and cytokinesis. These events are governed by the anaphase-promoting complex (APC), which triggers the ubiquitin-dependent proteolysis of key regulatory proteins: anaphase requires the destruction of the anaphase inhibitor Pds1, whereas mitotic exit requires the destruction of mitotic cyclins and the inactivation of Cdk1. We find that Pds1 is not only an inhibitor of anaphase, but also blocks cyclin destruction and mitotic exit by a mechanism independent of its effects on sister chromatid separation. Pds1 is also required for the mitotic arrest and inhibition of cyclin destruction that occurs after DNA damage. Even in anaphase cells, where Pds1 levels are normally low, DNA damage stabilizes Pds1 and prevents cyclin destruction and mitotic exit. Pds1 blocks cyclin destruction by inhibiting its binding partner Esp1. Mutations in ESP1 delay cyclin destruction; overexpression of ESP1 causes premature cyclin destruction in cells arrested in metaphase by spindle defects and in cells arrested in metaphase and anaphase by DNA damage. The effects of Esp1 are dependent on Cdc20 (an activating subunit of the APC) and on several additional proteins (Cdc5, Cdc14, Cdc15, Tem1) that form a regulatory network governing mitotic exit. We speculate that the inhibition of cyclin destruction by Pds1 may contribute to the ordering of late mitotic events by ensuring that mitotic exit is delayed until after anaphase is initiated. In addition, the stabilization of Pds1 after DNA damage provides a mechanism to delay both anaphase and mitotic exit while DNA repair occurs.  (+info)

SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (8/296)

We have identified SGT1 as a dosage suppressor of skp1-4, a mutation causing defects in yeast kinetochore function. Sgt1p physically associates with Skp1p in vivo and in vitro. SGT1 is an essential gene, and different sgt1 conditional mutants arrest with either a G1 or G2 DNA content. Genetic and phenotypic analyses of sgt1-3 (G2 allele) mutants support an essential role in kinetochore function. Sgt1p is required for assembling the yeast kinetochore complex, CBF3, via activation of Ctf13p. Sgt1p also associates with SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase. sgt1-5 (G1 allele) mutants are defective in Sic1p turnover in vivo and Cln1p ubiquitination in vitro. Human SGT1 rescues an sgt1 null mutation, suggesting that the function of SGT1 is conserved in evolution.  (+info)

During grain (L. Orysa;CycB2;2 usually do not present binding to Orysa;KRP3. Orysa;KRP3 could rescue fungus premature cell department because of the dominant positive appearance of mutant grain CDKA;1 indicating that Orysa;KRP3 inhibited grain CDK. These data claim that Orysa;KRP3 is involved with cell routine control of syncytial endosperm. L.) endosperm comprises a considerable proportion from the mature seed possesses a great 1428535-92-5 deal of carbohydrates. It really is a significant source of calories from fat for human beings and animals and in addition provides recycleables for items and biofuels. Comprehensive research provides been fond of enhancing the grain size, quality, and produce. A number of the restrictions of conventional grain breeding could be get over by biotechnological anatomist. Nevertheless, significant improvements need an understanding from the molecular procedures controlling endosperm advancement. Rice seed advancement begins with dual fertilization where the ...
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1OIT: Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation
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Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodula …
Recombinant human CDKN1B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 24.2 kDa.
The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control. Here, we show that p57(Kip2) is ...
The cortactin oncoprotein is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC), often due to amplification of the encoding gene (CTTN). While cortactin overexpression enhances invasive potential, recent research indicates that it also promotes cell proliferation, but how cortactin regulates the cell cycle machinery is unclear. In this article we report that stable short hairpin RNA-mediated cortactin knockdown in the 11q13-amplified cell line FaDu led to increased expression of the Cip/Kip cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/Cip1), p27(Kip1), and p57(Kip2) and inhibition of S-phase entry. These effects were associated with increased binding of p21(WAF1/Cip1) and p27(Kip1) to cyclin D1- and E1-containing complexes and decreased retinoblastoma protein phosphorylation. Cortactin regulated expression of p21(WAF1/Cip1) and p27(Kip1) at the transcriptional and posttranscriptional levels, respectively. The direct roles of p21(WAF1/Cip1), p27(Kip1), and p57(Kip2) ...
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small cell lung cancers (57.4% stage 1, 16.7% stage 2, and 25.9% stage 3) to determine whether the lack or altered expression of this protein correlates with neoplastic transformation and/or progression. We performed immunohistochemistry and Western blot analysis of each specimen. We found that tumors expressing low to undetectable levels of p27 contained high p27 degradation activity. When we evaluated the outcome of the patients in relationship to p27 expression, we found p27 to be a prognostic factor correlating with the overall survival times (P = 0.0012).. The possibility of a simple assay, such as the immunohistochemical analysis of p27 expression on routinely formalin-fixed, paraffin-embedded specimens, has considerable value for the prognosis of ...
This protein belongs to the CDKN2 cyclin-dependent kinase inhibitor family. p16 comprises four ankyrin repeats, each spanning a ... "CDKN2A - Cyclin-dependent kinase inhibitor 2A - Homo sapiens (Human) - CDKN2A gene & protein". www.uniprot.org. Retrieved 2016- ... p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins ... "CDKN2A cyclin dependent kinase inhibitor 2A [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-10-11. ...
PMID: 31212132 Structure-based discovery of cyclin-dependent protein kinase inhibitors. Martin MP, Endicott JA, Noble MEM. ... to conduct research into cyclin-dependent protein kinases (CDKs). She was awarded a Royal Society University Research ... Protein kinase inhibitors: insights into drug design from structure. Science. 2004 Mar 19;303(5665):1800-5. According to Google ... inhibits cyclin-dependent kinases. Nature cell biology. 1999 May;1(1):60-7. According to Google Scholar, this article has been ...
For example, DP00016 refers to the Cyclin-dependent kinase inhibitor 1 protein. Release 8 of DisProt contains more than 1400 ... Release 7 of DisProt contains information on more than 800 proteins. Each protein entry in DisProt is characterised by a ... Users can also browse through the entries (proteins or regions) by their identifier, detection method or PubMed ID. The entire ... Historically, the study of disordered proteins has been hampered by the lack of an organised resource collecting them and their ...
It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded ... CDKN1B has been shown to interact with: AKT1, CKS1B, Cyclin D3, Cyclin E1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4 ... "Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)". ... Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. ...
cyclin-dependent protein serine/threonine kinase activity. • protein kinase inhibitor activity. • protein kinase binding. • ... also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) ... cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A. External IDs. OMIM: 116899 MGI: 104556 HomoloGene: ... protein binding. • cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • ...
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. „Cell". 75 (4), s. 805-816, 1993. ... Li Y, Jenkins CW, Nichols MA, Xiong Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. „ ... a b Entrez Gene: CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1). ... proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 ...
The p16 protein is a cyclin dependent kinase inhibitor (CDK) inhibitor and it activates Rb tumor suppressor. p16 binds to CDK 4 ... p16Ink4a also activates pRB, but through inactivation of cyclin-dependent kinase 4 (Cdk 4) and cyclin-dependent kinase 6 (Cdk 6 ... p53 activates p21 which deactivates cyclin-dependent kinase 2(Cdk 2). Without Cdk 2, retinoblastoma protein (pRB) remains in ... Rivera-Torres J, José ES (2019). "Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and ...
... can be induced by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor. In ... cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor". Cell ... a cyclin-dependent kinase inhibitor, is dependent on p53 signaling". PLOS ONE. 8 (3): e59588. doi:10.1371/journal.pone.0059588 ... Fu W, Ma L, Chu B, Wang X, Bui MM, Gemmer J, Altiok S, Pledger WJ (Jun 2011). "The cyclin-dependent kinase inhibitor SCH 727965 ...
... notably the cyclin-dependent kinase inhibitor Sic1 - for ubiquitin-mediated protein degradation. CDC34 is required for ... CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ... a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1-2): 113-21. doi:10.1016/S0378-1119(00) ... Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme ...
... as well as cyclin dependent kinase inhibitor proteins. The human genome encodes over 600 putative E3 ligases, allowing for ... and an F-box protein, which varies. Around 70 human F-box proteins have been identified. F-box proteins contain an F-box, which ... The ligases must simultaneously distinguish their protein substrate from thousands of other proteins in the cell, and from ... recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein ...
cyclin-dependent protein serine/threonine kinase activity. • protein kinase inhibitor activity. • protein kinase binding. • GO: ... cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A. Зовнішні ІД. OMIM: 116899 MGI: 104556 HomoloGene: ... cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • cyclin binding. • ... protein stabilization. • positive regulation of cyclin-dependent protein kinase activity. • regulation of transcription from ...
"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805-816. doi:10.1016/ ... Yue Xiong and David Beach as a cyclin-CDK-PCNA interacting protein (p21), and as a senescence derived inhibitor by Noda. ... "p21 is a universal inhibitor of cyclin kinases". Nature. 366 (6456): 701-704. Bibcode:1993Natur.366..701X. doi:10.1038/366701a0 ... In 2013, his group reported a TRAIL-inducing compound TIC10 as a novel cancer therapeutic and dual inhibitor of ERK and Akt. ...
... may refer to Cheung Kong Infrastructure Holdings Circle K International Cyclin-dependent kinase inhibitor protein This ...
Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene. The protein encoded by this gene ... 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805-16. doi: ... It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase ... "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805-16. doi:10.1016/ ...
... serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor ... Myc-associated zinc finger protein is a protein that in humans is encoded by the MAZ gene. MAZ (gene) has been shown to ... a myc-associated zinc finger protein, are regulated by casein kinase II". Biochem. Biophys. Res. Commun. 262 (1): 198-205. doi: ... protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry ...
... which leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 and p16. ... The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. The ... Opioid growth factor receptor, also known as OGFr or the ζ-opioid receptor, is a protein which in humans is encoded by the OGFR ... Retinoblastoma protein becomes activated through the phosphorylation from CDKs, and leads to the progression of the cell cycle ...
The suspected mechanism is dependent on p27Kip1, a cyclin-dependent kinase inhibitor. p27Kip1 protein levels are elevated in ... Cyclins are proteins that control progression through the cell cycle by activating cyclin-dependent kinases. Destruction of a ... a peak of cyclin E protein would indicate the G1/S transition, a cyclin A peak would indicate late G2 phase, and a cyclin B ... Driving this conversion is Cdc7 and S-phase cyclin-dependent kinases, which are both upregulated after the G1/S transition. ...
... cyclin-dependent kinases (Cdk), cyclin-dependent kinase inhibitors (Cdkn), pocket proteins of the retinoblastoma (Rb) family, ... hESCs show that the activities of Cyclin E/Cdk2 and Cyclin A/Cdk2 complexes are cell cycle-dependent and the Rb checkpoint in ... Rather, the Cyclin E/Cdk2 complex is constitutively active throughout the cycle, keeping retinoblastoma protein (pRb) ... while Cyclin E and Cdk2 are active during the late G1 phase and S phase; and Cyclin A and Cdk2 are active in the S phase and G2 ...
... a type of toxin delivery between bacteria which requires direct contact Cyclin-dependent kinase inhibitor protein, a protein ... which inhibits cyclin-dependent kinase Contexts and Dependency Injection, a Java standard for the inversion of control design ...
... the CDKN2A gene which encodes cyclin-dependent kinase Inhibitor 2A, a protein that regulates cell proliferation and the CDKN2B ... This gene encodes CREB-binding protein, a protein that activates various transcription factors some of which are implicated in ... This gene encodes SET domain containing 2, a protein that acts to reduce the occurrence of gene deletions and tumor formation. ... TP53 encodes tumor suppressor p53, a protein that regulates cell proliferation, death, and tumor formation. Mutations in JAK- ...
... also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 The p21/ras protein, part of the RAt Sarcoma ... P21, p21 or P-21 may refer to: The p21/waf1 protein, ... family of proteins LÉ Emer (P21), a patrol vessel of the Irish ...
de 1993). «The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases». Cell (UNITED STATES) 75 ... de 2000). «p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6300- ... de 2000). «Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms». J. ... de 2003). «Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a ...
It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein ... Cyclin D1, Cyclin D3, P16, PPM1B, and PPP2CA. Cell cycle Cyclin-dependent kinase Cyclin-dependent kinase 4 Mitosis The ... "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by ... 2003). "Expression of Cyclin-Dependent Kinase 6, but Not Cyclin-Dependent Kinase 4, Alters Morphology of Cultured Mouse ...
"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805-16. doi:10.1016/ ... The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein ... Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ... Cyclin-dependent kinase 2 has been shown to interact with: BRCA1, CDK2AP1, CDKN1B CDKN3, CEBPA, Cyclin A1, Cyclin E1, Flap ...
Inactivation of cyclin D is triggered by several cyclin-dependent kinase inhibitor protein (CKIs) like the INK4 family (e.g. ... Cyclins are eukaryotic proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they activate. The ... activate cyclin D gene in response to integrin. p27kip1 and p21cip1 are cyclin-dependent kinase inhibitors (CKIs) which ... two more cyclin D proteins have been identified. The three homologues, called cyclin D1, cyclin D2, and cyclin D3 are expressed ...
... a low-molecular weight protein inhibitor of cyclin-dependent protein kinases (CDKs) - which has been localised to the p21 ... "CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)". U.S. National Library of Medicine. Soura E, ... Another mutation in the same gene results in a nonfunctional inhibitor of CDK4, a cyclin-dependent kinase that promotes cell ... Eventual resistance to BRAF and MEK inhibitors may be due to a cell surface protein known as EphA2 which is now being ...
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is ... This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6 ... "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to ... "Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)". Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, et al ...
This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also ... Tomoda K, Kubota Y, Kato J (March 1999). "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1". ... The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that ... April 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". ...
... (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C ... Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator ... "Entrez Gene: CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)". Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, ... Cyclin-dependent kinase inhibitor 1C has been shown to interact with: LIMK1, MYBL2, MyoD, and PCNA. ENSG00000129757 GRCh38: ...
... are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6". Molecular and Cellular Biology. 15 (5): 2672-81. doi: ... G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. The protein encoded by this gene belongs to ... Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation ... "Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo". Molecular and Cellular ...
cyclin-dependent protein kinase 5 activator activity. • lipid binding. Cellular component. • cytoplasm. • cyclin-dependent ... "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". J. Biol ... positive regulation of protein kinase activity. • regulation of cyclin-dependent protein serine/threonine kinase activity. • ... CDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory ...
Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by specific cyclins that ... the ATP-dependent proteolytic complex that was responsible for ubiquitin-dependent protein degradation was discovered and was ... or to result from the differential activity of the pro-apoptotic kinase JNK.[89] The ability of proteasome inhibitors to induce ... is one of the 19S subcomponents that also tightly binds the cyclin-dependent kinase CDK4 and plays a key role in recognizing ...
"Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6". Mol. Cell. Biol ... protein kinase activity. • kinase activity. • protein serine/threonine kinase activity. • cyclin-dependent protein serine/ ... protein binding. • ATP binding. • cyclin binding. • cyclin-dependent protein serine/threonine kinase activity. • macromolecular ... "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S. ...
"Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational ... McClain WH (November 1993). "Rules that govern tRNA identity in protein synthesis". Journal of Molecular Biology. 234 (2): 257- ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ... Both classes of aminoacyl-tRNA synthetases are multidomain proteins. In a typical scenario, an aaRS consists of a catalytic ...
Cyclin. *Cyclin-dependent kinase inhibitor protein. *Cyclin-dependent kinase. *Cyclin. Lipid. *Phosphoinositide phospholipase C ... Inhibitors[edit]. Another class of regulatory proteins, the Guanosine nucleotide dissociation inhibitors (GDIs), bind to the ... GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ...
All these phases in the cell cycle are highly regulated by cyclins, cyclin-dependent kinases, and other cell cycle proteins. ... CDK inhibitor. *INK4a/ARF (p14arf/p16, p15, p18, p19). *cip/kip (p21, p27, p57) ... Generation of pressure is dependent on formin-mediated F-actin nucleation[71] and Rho kinase (ROCK)-mediated myosin II ... Motor proteins then push the centrosomes along these microtubules to opposite sides of the cell. Although centrosomes help ...
"Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation". Nature Neuroscience. 10 ( ... which contain residues that can be directly modified by a series of protein kinases and protein phosphatases, as well as ... NMDAR/TRPM4 interaction interface inhibitors (also known as ‚interface inhibitors') disrupt the NMDAR/TRPM4 complex and ... "MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term ...
cyclin-dependent protein serine/threonine kinase inhibitor activity. • protein binding. • cyclin-dependent protein kinase ... protein complex binding. • metal ion binding. Cellular component. • cyclin-dependent protein kinase holoenzyme complex. • ... Cyclin-dependent kinase inhibitor 1A (p21, Cip1). Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human ... regulation of cyclin-dependent protein serine/threonine kinase activity. • G1/S transition of mitotic cell cycle. • G2/M ...
... phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase" ... In molecular biology, Tat is a protein that is encoded for by the tat gene in HIV-1.[1][2] Tat is a regulatory protein that ... October 2005). "4-Phenylcoumarins as HIV transcription inhibitors". Bioorg. Med. Chem. Lett. 15 (20): 4447-50. doi:10.1016/j. ... Protein transduction domain[edit]. Tat contains a protein transduction domain, which is therefore known as a cell-penetrating ...
The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a ... "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... protein binding. • ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...
Cyclin. *Cyclin-dependent kinase inhibitor protein. *Cyclin-dependent kinase. *Cyclin. Lipid. *Phosphoinositide phospholipase C ... protein complex binding. • signal transducer activity. • protein binding. • GTPase activity. • GTPase binding. • G-protein ... 1omw: Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and ... protein heterotrimerization. • Wnt signaling pathway, calcium modulating pathway. • protein folding. • G-protein coupled ...
Finally, the Akt protein kinase promotes cell survival through two pathways. Akt phosphorylates and inhibits Bad (a Bcl-2 ... Caspases are proteins that are highly conserved, cysteine-dependent aspartate-specific proteases. There are two types of ... The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in cells of the H460 cell line. XIAPs bind to the processed ... Cyclin. *A (A1, A2). *B (B1, B2, B3). *D (D1, D2, D3) ... Expression of viral proteins coupled to MHC proteins on the ...
GTP-dependent protein binding. • GTPase activity. • mitogen-activated protein kinase kinase kinase binding. • protein binding. ... Rho GDP-dissociation inhibitor binding. • ubiquitin protein ligase activity. • apolipoprotein A-I receptor binding. • ... Cyclin. *A (A1, A2). *B (B1, B2, B3). *D (D1, D2, D3) ... "The MAP kinase kinase kinase MLK2 co-localizes with activated ... protein kinase binding. • nucleotide binding. • GTP binding. • identical protein binding. Cellular component. • cytoplasm. • ...
Further information: CDK inhibitor. Cyclin-dependent kinases (CDKs) 4 and 6 are enzymes that have been shown to promote cell ... It also inhibits a number of transporter proteins and could thus theoretically interfere with the transport of other drugs in ... Ribociclib, sold under the brand name Kisqali,[1] is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of ... When used in combination with other drugs such as an ALK or an MEK inhibitor, ribociclib has been shown to have a synergistic ...
... and the cyclin dependent kinase inhibitors P27 and P21.». Leuk. Lymphoma 43 (1): 51-7. PMID 11908736. doi:10.1080/ ... Functional network of interactive proteins.». J. Biol. Chem. 274 (27): 18843-6. PMID 10383378. doi:10.1074/jbc.274.27.18843. ... de 1998). «The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF ... de 1998). «Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type ...
... cyclins and cyclin dependent kinases". Oncogene. 15 (2): 143-57. doi:10.1038/sj.onc.1201252. PMID 9244350.. ... "BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3". ... "miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors". Mol. Cell. 41 (2): 210-20. ... "BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site". Mol. Cell. Biol. 19 (7): ...
Cyclin. *Cyclin-dependent kinase inhibitor protein. *Cyclin-dependent kinase. *Cyclin. Lipid. *Phosphoinositide phospholipase C ... Types of G protein signaling[edit]. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ... G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside ... Heterotrimeric G proteins[edit]. Main article: Heterotrimeric G proteins. Different types of heterotrimeric G proteins share a ...
These transitions are controlled by the cyclin-dependent kinase Cdk1.[6] Though the proteins that control Cdk1 are well ... TOR is a serine/threonine kinase that can directly phosphorylate and inactivate a general inhibitor of eIF4E, named 4E-binding ... Wee1 protein is a tyrosine kinase that normally phosphorylates the Cdc2 cell cycle regulatory protein (the homolog of CDK1 in ... The protein kinase Cdr2 (which negatively regulates Wee1) and the Cdr2-related kinase Cdr1 (which directly phosphorylates and ...
... embryogenesis and showed a drastic reduction in the production but increased expression of Cyclin-Dependent Kinase Inhibitors ( ... Adenoviral E1A-associated protein of 300kDa (p300) and the CREB-binding protein (CBP) make up the next family of HATs.[10] This ... Binding of HDACs to MEF2 inhibits muscle differentiation, which can be reversed by action of Ca2+/calmodulin-dependent kinase ( ... HDACs 1 and 2 can also bind directly to DNA binding proteins such as Yin and Yang 1 (YY1), Rb binding protein 1 and Sp1.[5] ...
CDK抑制因子(英语:Cyclin-dependent kinase inhibitor protein). *INK4a/ARF(p14arf/p16、p15、p18、p19) ... Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. BioEssays. June 1995, 17 (6): 471-80. PMID ... 細胞週期的進行是由不同的週期素(Cyclin)所調控。週期素意味著這些蛋白質的表現量會隨著細胞週期的進行而有所變化,進而確認週期素原來是扮演細胞
Liu H, Di Cunto F, Imarisio S, Reid LM (Jan 2003). "Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M ... protein kinase activity. • PDZ domain binding. • SH3 domain binding. • scaffold protein binding. • metal ion binding. • kinase ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... protein serine/threonine kinase activity. • GO:0001948 protein binding. • ATP binding. • Rho GTPase binding. ...
"cAMP-dependent protein kinase" redirects here. It is not to be confused with AMP-activated protein kinase or cyclin-dependent ... "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". PNAS. 83: ... Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase was discovered by ... Protein Kinase A is directed to specific sub cellular locations after tethering to Protein kinase A anchoring proteins (AKAPs ...
Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q (October 2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA ... The existence of an RNAP III-dependent ncRNA transcriptome that regulates its RNAP II-dependent counterpart was supported by a ... binds and inhibits the CREB binding protein and p300 histone acetyltransferease activities on a repressed gene target, cyclin ... Liu WM, Chu WM, Choudary PV, Schmid CW (May 1995). "Cell stress and translational inhibitors transiently increase the abundance ...
Cyclin. *Cyclin-dependent kinase inhibitor protein. *Cyclin-dependent kinase. *Cyclin. Lipid. *Phosphoinositide phospholipase C ... Guanylyl cyclase activator (protein). References[edit]. *^ Sakurai K.; Chen J.; Kefalov V. (2011). "Role of guanylate cylcase ... Indirect/downstream NO modulators: ACE inhibitors/AT-II receptor antagonists (e.g., captopril, losartan) ... Guanylate cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and ...
cAMP-dependent protein kinase (EC 2.7.11.11). *Protein kinase A. *PRKACG. *PRKACB ... Dephospho-(reductase kinase) kinase (EC 2.7.11.3). *AMP-activated protein kinase α *PRKAA1 ... Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ... Myosin-heavy-chain kinase (EC 2.7.11.7). *Aurora kinase *Aurora A kinase ...
... an inhibitor of protein phosphatase 1. Sustained D1 receptor activity is kept in check by Cyclin-dependent kinase 5. Dopamine ... receptor activation of Ca2+/calmodulin-dependent protein kinase II can be cAMP dependent or independent.[15] ... D2 receptor signaling may mediate protein kinase B, arrestin beta 2, and GSK-3 activity, and inhibition of these proteins ... Dopamine receptors can also transactivate Receptor tyrosine kinases.[17] Beta Arrestin recruitment is mediated by G-protein ...
... leading to an accumulation of cyclin-dependent kinase inhibitors p21 and p27, and to subsequent G1-phase arrest, as seen in ... In vitro formation of a triketide lactone using a genetically modified protein derived from 6-deoxyerythronolide B synthase has ... Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the ... The first breakthrough in efforts to find a potent, specific, competitive inhibitor of HMG CoA reductase occurred in 1976, when ...
... cyclin-dependent kinase and DREAM complex. When it is time for a cell to enter S phase, complexes of cyclin-dependent kinases ( ... Furthermore, triple knockout, p16 addition, and Cdk 4/6 inhibitor addition experiments confirmed that Cyclin D- Cdk 4/6 is the ... cyclin E and cyclin A), which push the cell through the cell cycle by activating cyclin-dependent kinases, and a molecule ... negative regulation of protein serine/threonine kinase activity. • negative regulation of tau-protein kinase activity. • ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in ... Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed: ... Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase ... Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At ... inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with ...
A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several ... Seven cyclin-dependent kinase inhibitor proteins have thus far been identified. They are named by the small letter "p" followed ... Cyclin-Dependent+Kinase+Inhibitor+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ... "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325 ...
Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in ... Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or ... Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in ... cyclin-dependent protein serine/threonine kinase inhibitor activity Source: UniProtKB. *protein-containing complex binding ...
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.. Harper JW1, Adami GR, Wei N, ... The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S ... tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-Cdk2, cyclin D1-Cdk4, and ... CIP1 encodes a novel 21 kd protein that is found in cyclin A, cyclin D1, cyclin E, and Cdk2 immunoprecipitates. p21CIP1 is a ...
cyclin-dependent protein kinase activating kinase activity Source: Ensembl. *cyclin-dependent protein serine/threonine kinase ... cyclin-dependent kinase inhibitor 1Imported. Automatic assertion inferred from database entriesi ... tr,A0A2Y9ENU9,A0A2Y9ENU9_PHYMC cyclin-dependent kinase inhibitor 1 OS=Physeter macrocephalus OX=9755 GN=CDKN1A PE=3 SV=1 ... Protein kinase inhibitorARBA annotation. ,p>Information which has been generated by the UniProtKB automatic annotation system, ...
... we have employed an improved two-hybrid system to isolate human genes encoding Cdk-interacting proteins (Cips … ... The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S ... The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell. 1993 Nov 19;75(4):805-16. doi: ... The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S ...
Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C ... and HCV core protein additively repress the universal cyclin-dependent kinase inhibitor p21 gene at the transcription level. ... virus core protein.. Han HJ1, Jung EY, Lee WJ, Jang KL. ... hepatitis B virus X protein. *nucleocapsid protein, Hepatitis C ... we demonstrated that HBV X protein (HBx) ... Proteins*BioSystems. *BLAST (Basic Local Alignment Search Tool) ...
... Cancer ... Other kinase inhibitors are potent inhibitors of kinases involved in the control of cell cycle progression (cyclin-dependent ... Protein kinase C (PKC) is a cellular serine/threonine kinase with a central role in the mediation of mitogenic signals as well ... As a result, many kinase inhibitors that act by blocking the catalytic site are not highly specific and may act as inhibitors ...
The Cyclin-Dependent Protein Kinase Inhibitor Set controls the biological activity of Cyclin-Dependent Protein Kinase. This ... small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. - Find MSDS or SDS, a COA, ... Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem. 219428 Sigma-AldrichCyclin-Dependent Protein Kinase Inhibitor Set ... The Cyclin-Dependent Protein Kinase Inhibitor Set controls the biological activity of Cyclin-Dependent Protein Kinase. This ...
... is a specific inhibitor of cyclin-dependent kinases CDK4 and CDK6. CDK4 is a subunit of the protein kinase complex that is ... cyclin-dependent kinase 4 inhibitor D; INK4D; p19; CDK inhibitor p19INK4d; inhibitor of cyclin-dependent kinase 4d; cyclin- ... cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). Background. Cyclin-dependent kinase 4 inhibitor D (CDKN2D) is a ... cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the ...
cyclin-dependent protein kinase / protein phosphorylation / substrate specificity / enzyme inhibitor. Research Abstract. Cdc2 ... Development and application of specific inhibitors for cyclin-dependent protein kinases on the basis of their substrate ... kinase or cdk5, a member of cyclin-dependent protein kinases, phosphorylates a Ser/Thr site immediately followed by a proline ... activation of inhibitor 1 by cGMP-dependent protein kinase. Biochem.Biophys.Res.Commun.220. 777-783 (1996). *. Description. 「研 ...
Category Archives: Protein Kinase B. Furthermore, the relative percentage of intermediate cells increases in high-grade tumors ... For SDS\Web page protein analysis, decreased protein (10C25 g) of H22 cells, unloaded MPs and Bi2Se3/[email protected] had been loaded ... was utilized to monitor proteins migration. The causing gels had been stained with Coomassie blue to recognize the protein. = 3 ... Also unknown will be the kinases that co-ordinate and catalyze this complex BST-2/GRB2/ERK/BIM/Cas3 pathway. Activation of ERK1 ...
Category Archives: DNA-Dependent Protein Kinase. The administration of high dosages of therapeutic antibodies requires large- ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Interacts with CDK4 (both T-172-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase ... This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. UniProt ... This protein in other organisms (by gene name): Q96B52 - Homo sapiens 0 * A5X2G7 - Homo sapiens no matching PDB entries ...
View or download the Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem MSDS (Material Safety Data Sheet) or SDS for ... Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem SDS. Safety Data Sheet for Cyclin-Dependent Protein Kinase Inhibitor ... Material Safety Data Sheet or SDS for Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem 219428 from MilliporeSigma for ... Product Name Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem Select Language Select Language. Australia ...
Cyclin-Dependent Kinase Inhibitor Proteins*Cyclin-Dependent Kinase Inhibitor Proteins. *Cyclin Dependent Kinase Inhibitor ... "Cyclin-Dependent Kinase Inhibitor Proteins" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor ... CIP-KIP Cyclin-Dependent Kinase Inhibitors*CIP-KIP Cyclin-Dependent Kinase Inhibitors ... "Cyclin-Dependent Kinase Inhibitor Proteins".. *Cyclin-Dependent Kinase Inhibitor Proteins. *Cyclin-Dependent Kinase Inhibitor ...
ProteoGenix provides you the best Kinases proteins.Shop now from our 200 000 + products. ... Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A TAT from Prospec cat# pka-337. ... Proteins>Kinases proteins>Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A TAT Protein ... Buy Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A TAT Protein now. Add to cart ...
The only exception, in the latter group, was patients with tumours expressing high levels of cyclin D1, who did as well as the ... When the combined expression of p27 and cyclin D1 was related to survival, patients with high levels of p27, regardless of ... There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene ... protein have been demonstrated using immunohistochemistry in 189 cases of primary breast carcinoma with long-term follow-up. ...
Expression of cyclin-dependent kinase inhibitor 2A 16, tumour protein 53 and epidermal growth factor receptor in salivary gland ... Expression of cyclin-dependent kinase inhibitor 2A 16, tumour protein 53 and epidermal gro ... Tumor Suppressor Protein p53 / Cyclin-Dependent Kinase Inhibitor p16 Type of study: Incidence study Language: English Journal: ... Tumor Suppressor Protein p53 / Cyclin-Dependent Kinase Inhibitor p16 Type of study: Incidence study Language: English Journal: ...
Cyclin-Dependent Kinase Inhibitor Proteins. Antineoplastic Agents. Protein Kinase Inhibitors. Enzyme Inhibitors. Molecular ... A Study Of Oral Palbociclib (PD-0332991), A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer. The safety and ... PD-0332991 is in a new class of drugs called cyclin-dependent kinase (CDK inhibitors). This research study is the first time ... A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer. ...
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. Lookup NU author(s): ... Conference Name: Pharmacology & Therapeutics: 2nd International Confernce on Inhbitors of Protein Kinases ...
Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in ... aryl hydrocarbon receptor-interacting protein. *Cyclin-Dependent Kinase Inhibitor p27. Grant support. *G0701307/Medical ...
The cyclin-dependent kinase inhibitor p21 (p21WAF1/Cip1) is a multifunctional protein known. * Post author By cellsignaling ... The cyclin-dependent kinase inhibitor p21 (p21WAF1/Cip1) is a multifunctional protein known to promote cell cycle arrest and ... survival in response to p53-dependent and p53 independent stimuli. from the pro-apoptotic BH3-just proteins Puma. Under these ... Intro p21cip1/Waf1 (herein after called p21) can be a member from the Cip/Kip family members inhibitors of cell routine ...
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]. *Cyclin-Dependent Kinase Inhibitor p21 [D12.776.624.776. ... "Cyclin-Dependent Kinase Inhibitor p21" by people in Harvard Catalyst Profiles by year, and whether "Cyclin-Dependent Kinase ... A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with ... Cyclin-Dependent Kinase Inhibitor p21*Cyclin-Dependent Kinase Inhibitor p21. *Cyclin Dependent Kinase Inhibitor p21 ...
Cyclin-dependent kinase 5 (CDK5) is one of the major kinases involved in Tau phosphorylation, directly phosphorylating various ... Cyclin-dependent kinase 5 (CDK5) is one of the major kinases involved in Tau phosphorylation, directly phosphorylating various ... One of the main pathological changes that occurs in AD is the intracellular accumulation of hyperphosphorylated Tau protein in ... and systemic approaches are needed that allow an analysis of all the proteins involved. In this review, the role of the CDK5 ...
Arabidopsis Proteins Cell Cycle Cyclin-Dependent Kinase Inhibitor Proteins In Situ Hybridization Microscopy, Confocal Models, ... Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell ... Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell ... We demonstrate that RHF1a directly interacts with and targets a cyclin-dependent kinase inhibitor ICK4/KRP6 (for Interactors of ...
1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75(4):805-16. ... The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S ... CIP1 encodes a novel 21 kd protein that is found in cyclin A, cyclin D1, cyclin E, and Cdk2 immunoprecipitates. p21CIP1 is a ... tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-Cdk2, cyclin D1-Cdk4, and ...
Substrate and inhibitor of the cyclin-dependent; protein kinase Cdc28p (Swiss Prot. accession number; P38634); ; L9449.7; GAL2 ... osmosensing protein kinase; Hog1 (Swiss Prot. accession number P32485). Note that the; protein predicted to be encoded by this ... L8004.4; L8004.5; L8004.6; KIN2; Probable Serine/Threonine protein kinase (Swiss; Prot. accession number P13186); ; L8004.7; ... Membrane protein involved in endocytosis (PIR; accession number S45053); ; L9449.15; XDJ1; DnaJ protein homolog (Swiss Prot. ...
Keywords : Cyclin-dependent kinase inhibitor protein; Cyclin-dependent Kinases; Melanoma; Neoplasm metastasis. ... We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also ...
  • Acts either as an inhibitor or an activator of cyclin type D- CDK4 complexes depending on its phosphorylation state and/or stoichometry. (rcsb.org)
  • the interaction is inhibited by CDK2 -dependent phosphorylation on Thr-187. (rcsb.org)
  • Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. (rcsb.org)
  • p21CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-Cdk2, cyclin D1-Cdk4, and cyclin D2-Cdk4 complexes. (nih.gov)
  • This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. (merckmillipore.com)
  • In addition, we observed that cdk5 has a stronger preference for a proline and basic residues on the carboxyl-terminal side of the phosphorylation site when compared to the preference exhibited by cdc2 kinase. (nii.ac.jp)
  • Publications] Ando, S.: 'Keratin 8 phosphorylation in vitro by cAMP-dependent protein kinase occurs within the amino-and carboxyl-terminal end domains. (nii.ac.jp)
  • Publications] Ando, S: 'Keratin 8 phosphorylation in vitro by cAMP-dependent protein kinase occurs within the amino-and carboxyl-terminal end domains' Biochem.Biophys.Res.Commun. (nii.ac.jp)
  • Cyclin-dependent kinase 5 (CDK5) is one of the major kinases involved in Tau phosphorylation, directly phosphorylating various residues and simultaneously regulating various substrates such as kinases and phosphatases that influence Tau phosphorylation in a synergistic and antagonistic way. (frontiersin.org)
  • It remains unknown how the interaction between CDK5 and its substrates promotes Tau phosphorylation, and systemic approaches are needed that allow an analysis of all the proteins involved. (frontiersin.org)
  • The relationship among these theoretical and computational models shows that the regulation of Tau phosphorylation by PP2A and glycogen synthase kinase 3β (GSK3β) is essential under basal conditions and also describes the leading role of CDK5 under excitotoxic conditions, where silencing of CDK5 can generate changes in these enzymes to reverse a pathological condition that simulates AD. (frontiersin.org)
  • The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. (genecards.org)
  • p16 INK4a controls cell cycle progression by inhibiting phosphorylation of the retinoblastoma protein (Rb), while ARF prevents MDM2-mediated degradation of p53. (nature.com)
  • 25 This inhibitory effect on cyclin D/CDK4(6) complexes prevents phosphorylation of the retinoblastoma protein (Rb) and the subsequent release of transcription factors that are required for passage into and through S phase, in particular members of the E2F transcription factor family. (nature.com)
  • Here, we demonstrate how sequential phosphorylation of p19 INK4d at two sites first destabilizes and then unfolds the N-terminal half of the protein, which dissociates its cyclin-dependent protein kinase-inhibitory complex and primes p19 INK4d for cellular degradation. (pnas.org)
  • Our results define a structural mechanism by which phosphorylation-induced protein unfolding controls a key step in cell cycle progression. (pnas.org)
  • We delineate how the stepwise phosphorylation of p19 INK4d Ser66 and Ser76 by cell cycle-independent (p38) and -dependent protein kinases (CDK1), respectively, leads to local unfolding of the three N-terminal ankyrin repeats of p19 INK4d . (pnas.org)
  • Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic. (nii.ac.jp)
  • Phosphorylation of E2F-1 by cyclin A-cdk2. (nii.ac.jp)
  • Chemical synthesis of phosphopeptides using arylthio group for protection of phosphate : Application to identification of cdc2 kinase-phosphorylation sites. (nii.ac.jp)
  • The interaction of E2F with pRB and p107 are regulated via the phosphorylation of pRB and p107 by cyclin-dependent kinase. (nii.ac.jp)
  • Publications] Taya, Y.: 'Cell cycle-dependent phosphorylation of the tumor suppressor RB protein. (nii.ac.jp)
  • Cryptolepine induced DNA damage activated DNA damage response proteins as demonstrated by increased phosphorylation of ATM/ATR, BRCA1, Chk1/Chk2 and γH2AX. (aacrjournals.org)
  • Cryptolepine induced post-translational modifications such as phosphorylation and acetylation of p53, and inhibition of mdm2 protein expression resulted in activation and accumulation of p53 in SCC-13 and A431 cells. (aacrjournals.org)
  • A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (wikipedia.org)
  • Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (curehunter.com)
  • Nuclear translocation of Mig1 is regulated by differential phosphorylation of the protein in response to glucose availability, and recruitment of the general repression complex Ssn6-Tup1 to the DNA-bound Mig1 is required for the repression ( 5 , 17 , 48 ). (asm.org)
  • The transition from one stage of the cell cycle to another is regulated by the transcription of a number of cyclin genes, the degradation of cyclin proteins, and the modification of the cyclin-dependent kinase proteins by phosphorylation (reviewed in references 11 , 29 , and 30 ). (asm.org)
  • Mutated alleles of p16INK4a present in these tumors have lost their capacity to block cyclin D-CDK4 activity and to prevent RB phosphorylation during the cell cycle. (humpath.com)
  • Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast. (plantcell.org)
  • CDK inhibitors), and positive and negative phosphorylation events (i.e., at the Thr and/or Tyr residues of the T- and P-loops, respectively) ( Pines, 1995 ). (plantcell.org)
  • Furthermore, hinokitiol augmented p53 protein phosphorylation and subsequently led to enhanced p53 activity. (termedia.pl)
  • Phosphorylation of a number of nuclear proteins by the complex of CDK1 and CCNB1 is needed for G2/M transition (Chan et al. (wikipathways.org)
  • 2003). PLK2 is involved in the regulation of centrosome duplication through phosphorylation of centrosome-related proteins CENPJ (Chang et al. (wikipathways.org)
  • Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. (abcam.com)
  • Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. (abcam.com)
  • Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. (abcam.com)
  • Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. (abcam.com)
  • It binds to CDK4/6 inhibiting its kinase activity and prevents Rb phosphorylation. (wikipedia.org)
  • Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). (rcsb.org)
  • Potent inhibitor of cyclin E- and cyclin A- CDK2 complexes. (rcsb.org)
  • CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements. (rcsb.org)
  • A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity. (rcsb.org)
  • Binding to CDK2 leads to CDK2 /cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair (PubMed:19445729). (rcsb.org)
  • The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase transition in mammals. (nih.gov)
  • To identify potential Cdk2 regulators, we have employed an improved two-hybrid system to isolate human genes encoding Cdk-interacting proteins (Cips). (nih.gov)
  • CIP1 encodes a novel 21 kd protein that is found in cyclin A, cyclin D1, cyclin E, and Cdk2 immunoprecipitates. (nih.gov)
  • For example, the G1/S transition is regulated by Cdk2/cyclin E, Cdk3/unknown cyclin, Cdk4/cyclin D1-3, Cdk6/cyclin D1, and Cdk8/cyclin C. The frequent deregulation of Cdks and their regulators in cancer has stimulated the search for potent and selective inhibitors of Cdks for both research and therapeutic use. (merckmillipore.com)
  • p21 Cip1 (alternatively p21 Waf1 ), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 , is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, [5] though is primarily associated with inhibition of CDK2 . (wikipedia.org)
  • The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin - CDK2 , - CDK1 , and - CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase . (wikipedia.org)
  • This protein was reported to be specifically cleaved by CASP3 -like caspases , which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. (wikipedia.org)
  • also found that γ-irradiation of fibroblasts induced a p53 and p21 dependent cell cycle arrest, here p21 was found bound to inactive cyclin E / CDK2 complexes. (wikipedia.org)
  • The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. (genecards.org)
  • In contrast with the negative cell-cycle regulation, p21 may also serve as an assembly factor for cyclin D-CDK4/6 complexes, thus promoting cyclin D-dependent events, and downstream activation of cyclin E-CDK2 [ 7 , 8 ]. (intechopen.com)
  • Activation of p16 and p21 proteins downregulated expression of cyclin-dependent kinase 2 (CDK2), cyclin A, cyclin D1 and cyclin E and thus induced S-phase cell cycle arrest in NMSC cells with reduced expression of cell division proteins Cdc25a and Cdc25b. (aacrjournals.org)
  • The kinase-associated phosphatase (KAP) is a human dual-specificity protein phosphatase that was identified as a Cdc2- or Cdk2-interacting protein by a yeast two-hybrid screening, yet the biological significance of these interactions remains elusive. (asm.org)
  • Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity. (asm.org)
  • A Cdk-interacting protein called KAP/Cdi1 was first identified as a novel G 1 - and S-phase dual-specificity phosphatase that associates with Cdk2 and/or Cdc2 ( 22 , 24 ). (asm.org)
  • Further studies demonstrated that kinase-associated phosphatase (KAP) binds to Cdk2 and dephosphorylates Thr160 when the associated cyclin subunit is degraded or dissociated ( 2 , 42 ). (asm.org)
  • It has been reported that KAP may inactivate a specific protein kinase, probably Cdk2 or Cdc2, by removing phosphates from the cyclin complexes, and this may contribute to cell cycle control ( 2 , 24 , 42 ). (asm.org)
  • Transcriptionally induced by p53, the p21 protein binds and inhibits the cdk2-cyclin B/E complexes but increases stability and nuclear localization of cyclin D, stimulating assembly of the cdk4-cyclin D complex ( 3 , 5 - 13 ). (aacrjournals.org)
  • An inhibitor of cyclin-dependent kinases (proteins often involved in regulating the cell cycle), CYC065 targets two such kinases: CDK2 and CDK9. (dana-farber.org)
  • One of the ways that cancer cells circumvent CDK4/6 inhibitors is by activating CDK2, which is inhibited by CYC065. (dana-farber.org)
  • 1993). CDKN1A binds and inactivates CDK2 in complex with cyclin A (CCNA) or E (CCNE), thus preventing G1/S transition (Harper et al. (wikipathways.org)
  • the interaction is prevented by competitive binding of C10orf90 /FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A /p21 (By similarity). (rcsb.org)
  • Component of the ternary complex, cyclin D- CDK4 - CDKN1A . (rcsb.org)
  • This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. (genecards.org)
  • Among the many factors involved in these defense processes against DNA damage, p21 CDKN1A protein - known also as p21 (WAF1/CIP1/SDI1) - plays a key role in several fundamental biological processes, such as cell cycle control, DNA replication/repair, gene transcription, apoptosis, and cell motility [ 3 - 6 ]. (intechopen.com)
  • all these names have been substituted by a new terminology including all CDK inhibitors, and p21 is now named CDKN1A. (intechopen.com)
  • The cyclin-dependent kinase inhibitor p21 (CIP1, WAF1, CDKN1A ) is thought to be the main executor of p53-induced growth arrest ( 1 - 4 ). (aacrjournals.org)
  • Binding of the zinc finger protein ZNF385A (HZF), which is a transcriptional target of TP53, stimulates transcription of cell cycle arrest genes, such as CDKN1A (Das et al. (wikipathways.org)
  • The most prominent TP53 target involved in G1 arrest is the inhibitor of cyclin-dependent kinases CDKN1A (p21). (wikipathways.org)
  • For instance, in case of an irreversible damage, TP53 can induce transcription of an RNA binding protein PCBP4, which can bind and destabilize CDKN1A mRNA, thus alleviating G1 arrest and directing the affected cell towards G2 arrest and, possibly, apoptosis (Zhu and Chen 2000, Scoumanne et al. (wikipathways.org)
  • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. (nih.gov)
  • The cyclin-dependent kinase inhibitor p21 (p21WAF1/Cip1) is a multifunctional protein known to promote cell cycle arrest and survival in response to p53-dependent and p53 independent stimuli. (cell-signaling-pathways.com)
  • Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt. (harvard.edu)
  • This article is about the p21 Cip1 protein. (wikipedia.org)
  • Treatment with lenalidomide significantly inhibited CLL-cell proliferation, an effect that was associated with the p53-independent upregulation of the cyclin-dependent kinase inhibitor p21WAF1/Cip1 (p21). (slideshare.net)
  • Another potent CDK inhibitor, p21 WAF1/CIP1 , is a downstream effector of p53 and controls cell cycle progression by inhibiting the activity of a broader range of CDKs. (nature.com)
  • STAT5-induced expression of pim-1 , p21 WAF/Cip1 , and suppressor of cytokine signaling-1/STAT-induced STAT inhibitor-1/Janus kinase binding protein is responsible for induction of proliferation, differentiation, and apoptosis, respectively. (jimmunol.org)
  • Liver mRNA levels of transforming growth factor (TGF)-β1, connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF)-β, cyclin-dependent kinase inhibitor p27 kip (p27), and cyclin-dependent kinase inhibitor p21 WAF1/CIP1 (p21) were quantified by real-time polymerase chain reaction. (aspetjournals.org)
  • Immunoblotting was utilized to determine the protein level of p-extracellular signal-regulated kinase (ERK) 1/2, p-Akt, p-phosphoinositide 3-kinase (PI3K), p-Janus kinase 2 (JAK2), p-p53, and p21 Cip1 . (termedia.pl)
  • As a result, many kinase inhibitors that act by blocking the catalytic site are not highly specific and may act as inhibitors of both PKC and cdks. (nih.gov)
  • The eight cyclin-dependent protein kinases (Cdks) that have been identified to date play an essential role in the regulation of the cell cycle. (merckmillipore.com)
  • Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). (pnas.org)
  • Cell cycle progression may be also regulated, independently of cyclins and CDKs, thanks to the strong affinity binding to proliferating cell nuclear antigen (PCNA) [ 14 - 17 ], a protein playing a central role in DNA replication and repair, as well as in other processes of DNA metabolism [ 18 , 19 ]. (intechopen.com)
  • One contributing factor may be the sequestration of cyclins A, E, D1, and D3, as well as their cdk partners (cdks 1,2, 4 and 6), in the cytoplasm in quiescent adult human β-cells ( 9 - 12 ). (diabetesjournals.org)
  • Forced overexpression of cyclins/cdks permits induction of cell cycle entry associated with nuclear translocation of cyclins and cdks, suggesting that trafficking and proliferative events are linked ( 9 - 12 ). (diabetesjournals.org)
  • Therefore, identification of any factor or signal in human β-cells to increase cyclins/cdks and their nuclear trafficking may provide a useful hint to promote human β-cell proliferation and expansion for diabetes therapy. (diabetesjournals.org)
  • Cell cycle progression in mammals requires multiple cyclin-dependent kinases (Cdks) ( 44 ). (asm.org)
  • Proteins that interact with Cdks play distinct and specific roles in cell cycle regulation. (asm.org)
  • The central convergence point of these regulatory pathways are cyclin-dependent kinases (CDKs), and only if a certain threshold of CDK activity is reached will the entry into the next cell cycle phase be promoted. (plantcell.org)
  • CDK4 is a subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (creativebiomart.net)
  • Cell cycle progression is delayed or stopped by cyclin-dependent kinase inhibitors, abbreviated CDIs, CKIs or CDKIs. (wikipedia.org)
  • Intro p21cip1/Waf1 (herein after called p21) can be a member from the Cip/Kip family members inhibitors of cell routine progression that affiliates using the BKM120 (NVP-BKM120) cyclin/CDK complexes and with PCNA a processivity element for replication polymerase resulting in the inhibition of CDK actions and DNA replication [1]. (cell-signaling-pathways.com)
  • Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. (nextbio.com)
  • Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. (scielo.br)
  • This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. (genecards.org)
  • These results indicate that lenalidomide can directly inhibit proliferation of CLL cells in a CRBN/p21-dependent, but p53-independent, manner at concentrations achievable in vivo, potentially contributing to the capacity of this drug to inhibit disease- progression in patients with CLL. (slideshare.net)
  • A gene on chromosome 9q34.1 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. (thefreedictionary.com)
  • Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. (curehunter.com)
  • In the budding yeast Saccharomyces cerevisiae initiation and progression through the mitotic cell cycle are determined by the sequential activity of the cyclin-dependent kinase Cdc28. (genetics.org)
  • The role of this kinase in entry and progression through the meiotic cycle is unclear, since all cdc28 temperature-sensitive alleles are leaky for meiosis. (genetics.org)
  • As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. (plantcell.org)
  • Even though the theme of CDK-cyclin-regulated cell cycle progression appears to be conserved, there are also pronounced differences between animal and plant cell cycle controls. (plantcell.org)
  • Cyclin-dependent kinase 4 inhibitor D (CDKN2D) is a specific inhibitor of cyclin-dependent kinases CDK4 and CDK6. (creativebiomart.net)
  • If the benefits of CYC065 are borne out in subsequent trials, the drug could be particularly valuable for patients whose tumors don't respond to drugs that target two other cyclin-dependent kinases, CDK4 and CDK6, investigators say. (dana-farber.org)
  • p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. (wikipedia.org)
  • Forms a complex with cyclin type D- CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1 - CDK4 complex activation. (rcsb.org)
  • These Cdk/cyclin complexes reportedly regulate each step of the cell cycle. (merckmillipore.com)
  • A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. (rush.edu)
  • [12] [13] The binding of p21 to CDK complexes occurs through p21's N-terminal domain, which is homologous to the other CIP/KIP CDK inhibitors p27 and p57 . (wikipedia.org)
  • 23 24 p16 INK4a exerts a tumor-suppressive function by specifically interfering with the catalytic activity of complexes between cyclin D and cyclin-dependent kinase 4 (CDK4) or CDK6. (nature.com)
  • The main role of p21 is cell-cycle regulation, performed by inhibiting the activity of cyclin-CDK complexes thanks to direct interaction through specific sequences (termed CDK and Cy motifs) in the N-terminal domain of the protein [ 10 - 13 ]. (intechopen.com)
  • Upon administration, ALX148 binds to CD47 expressed on tumor cells and prevents the interaction of CD47 with its ligand SIRPa, a protein expressed on phagocytic cells. (cancer.gov)
  • Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping. (nii.ac.jp)
  • cDNA sequence, chromosomal localization of a novel human protein RBQ-1 which binds to the retinoblastoma gene product. (nii.ac.jp)
  • The NRG1 gene encodes a 25-kDa C 2 H 2 zinc finger protein which specifically binds to two regions in the upstream activation sequence of the STA1 gene, as judged by gel retardation and DNase I footprinting analyses. (asm.org)
  • The Mig1 glucose repressor is a zinc finger protein and binds to the GC-rich motif identified in the promoters of several glucose-repressed genes, including the GAL1 , GAL4 , SUC2 , and MAL genes ( 10 , 13 , 28 , 29 ). (asm.org)
  • Rapamycin binds intracellularly to FK506 (tacrolimus)-binding proteins (FKBPs). (aspetjournals.org)
  • Further biochemical analysis revealed that p19 INK4d directly binds to Raf kinase inhibitor PEBP1 and that p19 INK4d knockdown increased the expression of PEBP1 that in turn led to reduced ERK activation. (bloodjournal.org)
  • p16INK4a binds to cyclin D-CDK4 and promotes the inhibitory effects of RB. (humpath.com)
  • For example, PHF20 binds to TP53 dimethylated on lysine residues K370 and K382 by unidentified protein lysine methyltransferase(s) and interferes with MDM2 binding, resulting in prolonged TP53 half-life (Cui et al. (wikipathways.org)
  • 2004). GADD45A binds Aurora kinase A (AURKA), inhibiting its catalytic activity and preventing AURKA-mediated G2/M transition (Shao et al. (wikipathways.org)
  • Also, other proteins which involved in the same pathway with cdkn2d were listed below. (creativebiomart.net)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast. (umu.se)
  • We have previously discovered the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at mitosis via activation of the c-Jun NH 2 -terminal kinase pathway. (aacrjournals.org)
  • GATA1 protein level is regulated by p19 INK4d via PEBP1-pERK-HSP70-GATA1 pathway. (bloodjournal.org)
  • The expression status of hormone and growth factor receptors dictates the options for chemo‑endocrine and/or pathway selective small molecule inhibitor‑based treatments. (spandidos-publications.com)
  • The identification of molecular subtypes dictates specific chemo-endocrine therapy and pathway selective small molecule inhibitor-based treatment options. (spandidos-publications.com)
  • The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. (patents.com)
  • Cytotoxic drugs commonly used in cancer therapy promote tumor cell death by inducing apoptosis, but the cell death pathway(s) is likely dependent on the mechanism of drug action. (aspetjournals.org)
  • p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. (wikipathways.org)
  • In HPV-transformed cells, the downstream p16 ink4a -CDK4-pRB pathway is blocked by the inactivation of pRB through the HPV E7 protein, and it results in the nuclear and cellular accumulation of the cyclin-dependent kinase inhibitor p16 ink4a [ 2 , 3 ]. (biomedcentral.com)
  • P16/Rb pathway collaborates with the mitogenic signaling cascade for the induction of reactive oxygen species, which activates the protein kinase C delta, leading to an irreversible cell cycle arrest. (wikipedia.org)
  • Alvocidib is an investigational small molecule inhibitor of cyclin-dependent kinase 9 , a protein important to the regulation of Myc. (thefreedictionary.com)
  • tumor growth in preclinical breast malignancy models and assessment of BST-2, estrogen receptor (ER), progesterone receptor (PR), human being epidermal growth element receptor 2 (HER2) and Myc protein levels in human being breast tumor cells. (handselfdn.org)
  • Several function as tumor suppressor proteins. (wikipedia.org)
  • Therefore an insufficient source in nutrients might not come with an overt influence on tumor cell viability because of p21 induction nonetheless it primes these cells to perish and sensitizes these to the deleterious ramifications of Bcl-xL inhibitors no matter their p53 position. (cell-signaling-pathways.com)
  • A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. (harvard.edu)
  • Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis. (harvard.edu)
  • The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. (harvard.edu)
  • Tumor suppressor protein p53. (scielo.br)
  • This induces pro-phagocytic signaling mediated by the binding of the pro-phagocytic signaling protein calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. (cancer.gov)
  • CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. (cancer.gov)
  • p57KIP2, a structurally distinct member of the p21CIP1 Cdk-inhibitor family, is a candidate tumor suppressor gene. (atcc.org)
  • Similarly, there was no evidence of cellular protection, or of effects on p53-dependent gene transcription, or on translation of MDM-2 or p21 following UV treatment of these human tumor cell lines. (aacrjournals.org)
  • The loss of tumor suppressor proteins is a hallmark of human cancer ( 1 ). (aacrjournals.org)
  • Among these, the mammalian G 1 Cdk inhibitors have been shown to be involved in diverse processes such as repair of DNA damage, differentiation, tumor suppression, and cellular senescence ( 12 , 22 , 24 , 25 , 37 , 52 ). (asm.org)
  • 1993 ) Tumor suppressor genes encoding proteins required for cell interactions and signal transduction. (biologists.org)
  • We conclude that, in a tumor cell line of epithelial origin, the apoptosis following exposure to anthracyclines is an active process requiring protein synthesis and drug interaction with nuclear structures. (aspetjournals.org)
  • Cyclin-dependent kinase inhibitor 2A ( CDKN2A ), located on chromosome 9p21 encodes proteins that act as tumor suppressors. (bcidaho.com)
  • P14ARF induces cell cycle arrest in G2 phase and subsequent apoptosis in a P53-dependent and P53-independent manner, and thus is regarded as a tumor suppressor. (wikipedia.org)
  • p21 is a potent cyclin-dependent kinase inhibitor (CKI). (wikipedia.org)
  • Potent inhibitor. (genecards.org)
  • it was first described as a potent inhibitor of cell proliferation and DNA replication, both in physiological conditions and after DNA damage [ 7 , 8 ]. (intechopen.com)
  • Furthermore, local perivascular application of the potent and selective arginase inhibitors S -(2-boronoethyl)- l -cysteine (BEC) or N G -hydroxy-nor- l -arginine (L-OHNA) immediately after injury markedly attenuated medial and neointimal DNA synthesis and neointima formation. (ahajournals.org)
  • As structural mutations and/or gene amplification in Bcr-Abl can circumvent an otherwise potent anticancer drug such as imatinib, targeting Bcr-Abl expression as well as its kinase activity could be a novel additional therapeutic approach for the treatment of Bcr-Abl(+) myeloid leukemia. (aacrjournals.org)
  • identified a protein p21 (WAF1) which was present in cells expressing wild type p53 but not those with mutant p53, moreover constitutive expression of p21 led to cell cycle arrest in a number of cell types. (wikipedia.org)
  • Inhibition of PKC by a novel group of chemical agents (PKC inhibitors) can induce apoptosis in some malignant cell lines, act as differentiating agents, and enhance the effect of cytotoxic chemotherapy. (nih.gov)
  • Cdk inhibitors are able to induce cell cycle arrest in neoplastic cells and also act as enhancers of chemotherapy-induced apoptosis. (nih.gov)
  • Using these constitutively active forms of STAT5, we found that activation of STAT5 induced cytokine-independent growth of IL-3-dependent cells ( 8 , 9 ), and that STAT5 manifested a variety of biological functions including proliferation, differentiation, and apoptosis of Ba/F3 cells through up-regulation of a variety of target genes of STAT5 ( 10 ). (jimmunol.org)
  • The oncogenic Bcr-Abl tyrosine kinase activates various signaling pathways including phosphoinositide 3-kinase/Akt and nuclear factor-κB that mediate proliferation, transformation, and apoptosis resistance in Bcr-Abl(+) myeloid leukemia cells. (aacrjournals.org)
  • Interestingly, a second p53-induced transcript from the p21 gene, p21B ( Fig. 1 ) was recently identified and found to encode a protein expressing proapoptotic activity ( 14 ), suggesting a role for the p21 gene in both cell cycle arrest and apoptosis. (aacrjournals.org)
  • We also observed that neither MEN 10755 nor DXR were able to induce apoptosis in A2780 cells deprived of the nucleus but retaining an intact mitochondrial function (cytoplasts) and that apoptosis induced by either anthracycline was inhibited by cycloheximide, indicating that it is an active process requiring new protein synthesis. (aspetjournals.org)
  • Both the caspases inhibitors, ZVAD-fmk and DEVD-cho, inhibited at similar extent apoptosis induced by either DXR or MEN 10755, suggesting an involvement of caspase-3 in this response. (aspetjournals.org)
  • Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury. (wikipathways.org)
  • p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion. (wikipathways.org)
  • p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. (wikipathways.org)
  • Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. (wikipathways.org)
  • Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. (wikipathways.org)
  • Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neopla. (cdc.gov)
  • The embryonic development of anterior and intermediate lobes is initiated by formation of a rudimentary Rathke's pouch, followed by development of a definitive pouch, which is critically dependent on expression of LIM homeobox genes Lhx3 and Lhx4 ( 1 , 2 ). (frontiersin.org)
  • Subsequent to DNA binding at sites termed E-boxes (CANNTG), activation domains within the dimerized E-proteins stimulate transcription of their target genes. (jimmunol.org)
  • Although drug-dependent microtubule disruption results in the up-regulation of p53 expression, the relationship between p53-driven genes and drug sensitivity remains controversial as the response is drug and cell type dependent. (aacrjournals.org)
  • One of the candidate genes that satisfied all these requirements encodes inhibitor of DNA-binding (Id) proteins, a family of helix-loop-helix (HLH) transcriptional regulatory proteins 11 . (nature.com)
  • In the absence of glucose, the Snf1 kinase inhibits the function of Mig1 protein directly or indirectly, leading to derepression of glucose-repressed genes ( 3 , 4 ). (asm.org)
  • Consistent with this role in cell fate determination and differentiation, many bHLH genes are expressed in a tissue-specific manner (class B bHLH proteins). (biologists.org)
  • A sub-class of HLH genes, which lack the basic DNA-binding domain, is known as Inhibitors of DNA binding or ID genes. (biologists.org)
  • Stockinger, Eric 2005-05-02 00:00:00 The Arabidopsis CBF proteins activate expression of a set of genes whose upstream regulatory sequences typically harbor one or more copies of the CRT/DRE low temperature cis-acting DNA regulatory element. (deepdyve.com)
  • The Arabidopsis CBF proteins activate expression of a set of genes whose upstream regulatory sequences typically harbor one or more copies of the CRT/DRE low temperature cis-acting DNA regulatory element. (deepdyve.com)
  • Murray, J.A.H. 2004-10-03 00:00:00 Mammalian E2F transcription factors are composed of E2F and DP subunits, and with their negative regulators, Rb-related proteins, govern expression of cell-division-related genes. (deepdyve.com)
  • Consensus E2F-binding sites were identified in promoters of several cell cycle related genes, including the D-type cyclin CycD3 and the Arabidopsis homologue of the replication origin protein CDC6. (deepdyve.com)
  • Mammalian E2F transcription factors are composed of E2F and DP subunits, and with their negative regulators, Rb-related proteins, govern expression of cell-division-related genes. (deepdyve.com)
  • This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. (sdsc.edu)
  • p27, cyclin D1, and retinoblastoma (Rb) protein have been demonstrated using immunohistochemistry in 189 cases of primary breast carcinoma with long-term follow-up. (ox.ac.uk)
  • There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product (pRb), corresponding to their close interactions in regulating the G1/S transition in the cell cycle. (ox.ac.uk)
  • 70-kDa heat shock cognate protein directly interacts with N-terminal region of the retinoblastoma gene product pRb-identification of a novel region of pRb mediating protein interaction. (nii.ac.jp)
  • Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. (ox.ac.uk)
  • We therefore assessed oral salivary gland neoplasms to identify associations between HPV and infection -related epidermal growth factor receptor (EGFR), cyclin-dependent kinase inhibitor 2A (CDKN2A/p16) and tumour protein p53 (TP53). (bvsalud.org)
  • We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. (scielo.br)
  • CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. (wikipedia.org)
  • Protein kinase C (PKC) is a cellular serine/threonine kinase with a central role in the mediation of mitogenic signals as well as the regulation of antiapoptotic signals. (nih.gov)
  • cdkn2d has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. (creativebiomart.net)
  • GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity . (genecards.org)
  • Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of downstream cell cycle arrest. (wikipedia.org)
  • In addition, LNO(2) induced growth arrest of VSMCs in the G(1)/S phase of the cell cycle with an upregulation of the cyclin-dependent kinase inhibitor p27(kip1). (biomedsearch.com)
  • Neither compound had any effect on p53, p21, or MDM-2 protein expression following ionizing radiation exposure and there was no evidence of any abrogation of p53-dependent, ionizing radiation-induced cell cycle arrest. (aacrjournals.org)
  • Furthermore treatment with a panel of HDAC inhibitors showed clustering of activities for a subset of inhibitors, causing G2 cell cycle arrest, Sp1 acetylation, p21 and Bak over-expression, all with very similar EC 50 concentrations. (pubmedcentralcanada.ca)
  • 1997) and contributes to G2 arrest by binding to the complex of CDK1 and CCNB1 (cyclin B1) and preventing its translocation to the nucleus. (wikipathways.org)
  • Consistent with its localization, we show by yeast two-hybrid analysis that Corolla strongly interacts with Cona, a central element protein, demonstrating the first direct interaction between two inner-synaptonemal complex proteins in Drosophila . (genetics.org)
  • HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting CDK9 may have a role in AIDS. (thefreedictionary.com)
  • the interaction is required for cyclin D and CDK4 complex assembly, induces nuclear translocation and activates the CDK4 kinase activity. (rcsb.org)
  • 1994 ) A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signalling pathways. (biologists.org)
  • Here, we demonstrated that HBV X protein (HBx) and HCV core protein additively repress the universal cyclin-dependent kinase inhibitor p21 gene at the transcription level. (nih.gov)
  • Thyroid transcription factor 1 is a nuclear protein of the NKx2 family of homeodomain transcription factors. (redorbit.com)
  • The Medicago CDKC;1-CYCLINT;1 kinase complex phosphorylates the carboxy-terminal domain of RNA polymerase II and promotes transcription. (umu.se)
  • The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. (umu.se)
  • Basic helix-loop-helix (bHLH) family E-protein transcription factors have been implicated in the regulation of both differentiation and proliferation during T cell development. (jimmunol.org)
  • To determine why, we explored the human PRL-prolactin receptor (hPRLR)-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5)-cyclin-cdk signaling cascade in human β-cells. (diabetesjournals.org)
  • DNA-bound LexA-Nrg1 represses transcription of a target gene 10.7-fold in a glucose-dependent manner, and this repression is abolished in both ssn6 and tup1 mutants. (asm.org)
  • The plasmid bears the TPK2 gene, encoding a yeast cyclic AMP-dependent protein kinase, whose level of transcription is modulated by upstream regulatory elements ( 1 , 41 ) of the STA1 promoter. (asm.org)
  • Consistent with this, we show that AtE2F1 and AtE2F3 activate transcription in yeast cells and bind a plant Rb protein, but AtE2F2 cannot activate transcription or bind Rb. (deepdyve.com)
  • Binding of ASPP family proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) to TP53 stimulates transcription of pro-apoptotic TP53 targets (Samuels-Lev et al. (wikipathways.org)
  • In addition, P14ARF could down-regulate E2F-dependent transcription and plays a role in the control of the G1 to S phase transition as well. (wikipedia.org)
  • 1996 ) Oncogenic Ras activation of Raf/Mitogen-Activated Protein Kinase-idependent pathways is sufficient to cause tumorgenic transformation. (biologists.org)
  • Cyclin-dependent protein kinases and their inhibitors, such as p19 INK4d , regulate the different stages of the cell cycle. (pnas.org)
  • These results gave useful information for developing spesific substrates and competitive inhibitors for each kinase. (nii.ac.jp)
  • To obtain substrates/inhibitors which are resistant to enzymatic proteolysis, we undertook a synthesis of cyclic or retro-inverso peptides. (nii.ac.jp)
  • A phospho-mimicry T161D substitution restored the primary defect of cdka;1 mutants, and although the T161D substitution displayed a dramatically reduced kinase activity with a compromised ability to bind substrates, homozygous mutant plants were recovered. (plantcell.org)
  • The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. (wikipedia.org)
  • Imatinib mesylate (Gleevec, STI-571) is a selective tyrosine kinase inhibitor that has been proven to be a powerful agent for leukemias caused by Bcr/Abl, but the emergence of imatinib resistance underscores the need for additional therapies ( 2 ). (aacrjournals.org)
  • Thus, selective estrogen receptor modulators, selective estrogen receptor degraders, aromatase inhibitors with or without CDK 4/6 inhibitors ( 3-5 ), human epidermal growth factor receptor-2 (HER-2)-targeted ( 6 ), PI3K/AKT-targeted or m-TOR-targeted ( 7-10 ) therapeutic options represent the treatment of choice. (spandidos-publications.com)
  • Silencing cereblon (CRBN), a known molecular target of lenalidomide, impaired the capacity of lenalidomide to induce expression of p21, inhibit CD154-induced CLL-cell proliferation, or enhance the degradation of Ikaros family zinc finger proteins 1 and 3 (IKZF1 and IKZF3). (slideshare.net)
  • N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. (wikipedia.org)
  • p16INK4 gene encodes a specific inhibitor of cyclin-dependent kinase 4 (CDK4). (humpath.com)
  • This gene encodes two proteins, p16 and p14ARF, which are transcribed from the same second and third exons but alternative first exons: p16 from exon 1α and ARF from exon 1β. (wikipedia.org)
  • the interaction inhibits cyclin D- CDK4 kinase activity. (sdsc.edu)
  • the interaction promotes the assembly of the cyclin D- CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4 (PubMed:9106657). (rcsb.org)
  • Forms a ternary complex composed of cyclin D, CDK4 and CDKN1B . (rcsb.org)
  • CDKN1B (Cyclin Dependent Kinase Inhibitor 1B) is a Protein Coding gene. (genecards.org)
  • Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1 . (rcsb.org)
  • At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. (rcsb.org)
  • The Cyclin-Dependent Protein Kinase Inhibitor Set controls the biological activity of Cyclin-Dependent Protein Kinase. (merckmillipore.com)
  • Recent work exploring p21 activation in response to DNA damage at a single-cell level have demonstrated that pulsatile p53 activity leads to subsequent pulses of p21, and that the strength of p21 activation is cell cycle phase dependent. (wikipedia.org)
  • Furthermore, LNO(2) triggered nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation and activation of the antioxidant-responsive element-driven transcriptional activity via impairing Kelch-like ECH-associating protein 1 (Keap1)-mediated negative control of Nrf2 activity in VSMCs. (biomedsearch.com)
  • Trichocyalides A and B, new inhibitors of alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblasts, produced by Trichoderma sp. (nii.ac.jp)
  • Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. (plantphysiol.org)
  • Methods and Results- Balloon injury of rat carotid arteries resulted in a sustained increase in arginase activity in the vessel wall and the induction of arginase I protein in both the media and neointima of injured vessels. (ahajournals.org)
  • Substantial arginase I protein and arginase activity was also detected in rat cultured aortic VSMCs. (ahajournals.org)
  • The discovery that Bcr/Abl is required for the pathogenesis of chronic myelogenous leukemia (CML) and that the tyrosine kinase activity of ABL is essential for Bcr/Abl-mediated transformation made the ABL kinase an attractive target for clinical intervention ( 1 ). (aacrjournals.org)
  • The activity of these kinases depends on their association with a family of positive regulatory protein subunits known as cyclins during the cell cycle. (asm.org)
  • CASP-3 cleavage of RAD51 results in a functional decrease in RAD51 strand exchange activity and inhibition of caspase 3 activity increases RAD51 protein levels. (creativebiomart.net)
  • The four major regulatory inputs affecting CDK activity are the binding of positive cofactors (i.e., cyclins), negative regulators (i.e. (plantcell.org)
  • Interestingly, hinokitiol induced promoter activity of p21 and p21 protein expression in VSMCs. (termedia.pl)
  • It is the physiological inhibitor of MDM2, an E3 ubiquitin ligase controlling the activity and stability of P53, and loss of P14ARF activity may have a similar effect as loss of P53. (wikipedia.org)
  • The cell type-dependent different EBV latent gene expression patterns appear to be determined by the cellular epigenetic machinery and similarly viral oncoproteins recruit epigenetic regulators in order to deregulate the cellular gene expression profile resulting in several human cancers. (mdpi.com)
  • The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. (thermofisher.com)
  • CDK inhibitors: cell cycle regulators and beyond. (springer.com)
  • Li Y, Jenkins CW, Nichols MA, Xiong Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21 . (wikipedia.org)
  • 2012). Long noncoding RNAs can contribute to p53-dependent transcriptional responses (Huarte et al. (wikipathways.org)
  • 2012). Two polo-like kinases, PLK2 and PLK3, are direct transcriptional targets of TP53. (wikipathways.org)
  • Surprisingly, mouse (but not human) Stat5a overexpression led to upregulation of cyclins D1-3 and cdk4, as well as their nuclear translocation, all of which are associated with β-cell cycle entry. (diabetesjournals.org)
  • Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein. (nih.gov)
  • When the combined expression of p27 and cyclin D1 was related to survival, patients with high levels of p27, regardless of their cyclin D1 status, did well, whilst those with low p27 had a poor outcome. (ox.ac.uk)
  • LNO(2) upregulated the expression of Nrf2 protein levels, but not mRNA levels, in VSMCs. (biomedsearch.com)
  • The upregulation of p21 was controlled by p53 expression in HepG2 but not in Hep3B despite upregulation of Bax protein in both cell lines. (hindawi.com)
  • In the lung, it regulates the expression of surfactant protein A, surfactant protein B, surfactant protein C, and Clara cell secretory protein. (redorbit.com)
  • In turn, activated p53 enhanced protein expression of cyclin-dependent kinase inhibitors p16 and p21. (aacrjournals.org)
  • Moreover, treatment of VSMCs with BEC or L-OHNA, or knockdown of arginase I protein, arrested cells in the G 0 /G 1 phase of the cell cycle and induced the expression of the cyclin-dependent protein kinase inhibitor, p21. (ahajournals.org)
  • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. (wikipedia.org)
  • This compound has been reported to inhibit a number of p53-dependent processes in vitro , including UV-induced, p53-dependent β-gal expression, UV-induced cyclin G, p21, and MDM-2 protein expression ( 17 ). (aacrjournals.org)
  • We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N -acetylcysteine blunted xanthohumol-induced events. (aacrjournals.org)
  • Importantly, the levels of hypoxia-induced CSC-sphere formation and Id2 expression were successfully attenuated by treatment with a Wnt/β-catenin-signaling inhibitor. (nature.com)
  • Rather it led to decreased expression of GATA1 protein. (bloodjournal.org)
  • As GATA1 protein is protected by nuclear HSP70, we examined the effects of p19 INK4d knockdown on HSP70 and found that p19 INK4d knockdown led to decreased expression of HSP70 and its nuclear localization. (bloodjournal.org)
  • Expression of a recombinant Sp1 mutant (K703A), which could not be acetylated, resulted in increased expression of the lipoxygenase (12-LOX) gene [ 3 ] whilst treatment with HDAC inhibitors attenuated the expression of COX-2 in HT29 cells and IGFBP3 in CaCo2 cells [ 5 , 6 ]. (pubmedcentralcanada.ca)
  • Inhibition of cysteine proteinases and proteosome by Ras, Ran and cyclin. (nii.ac.jp)
  • Cdc2 kinase or cdk5, a member of cyclin-dependent protein kinases, phosphorylates a Ser/Thr site immediately followed by a proline which acts as the substrate specificity determinant. (nii.ac.jp)
  • Vesicular transport protein (Swiss Prot. (bio.net)
  • protein kinase Cdc28p (Swiss Prot. (bio.net)
  • P24A protein (unknown function) (Swiss Prot. (bio.net)
  • DnaJ protein homolog (Swiss Prot. (bio.net)
  • Choline kinase (Swiss Prot. (bio.net)
  • Publications] Tokui, T.: 'Enhancement of smooth muscle contraction with protein phosphatase inhibitor 1 :activation of inhibitor 1 by cGMP-dependent protein kinase. (nii.ac.jp)
  • [6] Specifically it contains a Cy1 motif in the N-terminal half, and weaker Cy2 motif in the C-terminal domain that allow it to bind CDK in a region that blocks its ability to complex with cyclins and thus prevent CDK activation. (wikipedia.org)
  • Activation of an alfalfa cyclin-dependent kinase inhibitor by calmodulin-like domain protein kinase. (umu.se)
  • 1992 ) Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. (biologists.org)
  • 1996 ) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. (biologists.org)
  • Apoptotic cell death induced by activation of the Fas/Fas-L system requires a multistep cascade of biochemical events: the trimerization of Fas receptor induced by Fas-L stimulates the formation of a death-inducing signaling complex, which consists of the adapter protein FADD and the protease FLICE/caspase-8. (aspetjournals.org)
  • Interestingly, cyclin D2-in contrast to its abundance and essential presence for rodent β-cell proliferation ( 13 - 15 )-is either absent or present at very low levels in human β-cells ( 16 - 19 ). (diabetesjournals.org)
  • A variant of signal regulatory protein alpha (SIRPa) that antagonizes the human cell surface antigen CD47, with potential phagocytosis-inducing, immunostimulating and antineoplastic activities. (cancer.gov)
  • MRE treatment induced apoptotic effects to HepG2 cells in a caspase-dependent manner and via upregulating p53/p21 and PCNA. (hindawi.com)
  • Lucilactaene, a New Cell Cycle Inhibitor in p53-Transfected Cancer Cells, Produced by a Fusarium sp. (nii.ac.jp)
  • All but the p53-null cells displayed p53 protein accumulation in a time-dependent manner on noscapine treatment. (aacrjournals.org)
  • Transferrin family proteins are highly abundant and plays important role in transport and storage of iron in cells and tissues. (jcancer.org)
  • Taken together our data suggest a mechanistic model for the chemopreventive actions of butyrate in colon epithelial cells, and provide new insight into the differential activities some classes of HDAC inhibitors. (pubmedcentralcanada.ca)
  • Cyclic peptides which represent the site of histone or vimentin were effectively phosphorylated by cdc2 kinase. (nii.ac.jp)
  • Publications] Ando, S.: 'Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5' J.Biochem.122. (nii.ac.jp)
  • Indeed, in Schizosaccharomyces pombe , the Mcm proteins that are essential for DNA replication in the mitotic cell cycle are not required for premeiotic DNA replication ( F orsburg and H odson 2000 ). (genetics.org)