Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Taxes: Governmental levies on property, inheritance, gifts, etc.Prescription Fees: The charge levied on the consumer for drugs or therapy prescribed under written order of a physician or other health professional.Philately: Study of stamps or postal markings. It usually refers to the design and commemorative aspects of the stamp.Great BritainGermanyMedicine, Arabic: Traditional Arabic methods used in medicine in the ARAB WORLD.Faculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Physician Assistants: Health professionals who practice medicine as members of a team with their supervising physicians. They deliver a broad range of medical and surgical services to diverse populations in rural and urban settings. Duties may include physical exams, diagnosis and treatment of disease, interpretation of tests, assist in surgery, and prescribe medications. (from http://www.aapa.orglabout-pas accessed 2114/2011)History, 20th Century: Time period from 1901 through 2000 of the common era.Schools, Medical: Educational institutions for individuals specializing in the field of medicine.Biophysics: The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.History, 19th Century: Time period from 1801 through 1900 of the common era.Spin Labels: Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)Polymyxins: Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.Electron Spin Resonance Spectroscopy: A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.Polymyxin B: A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Percussion: Act of striking a part with short, sharp blows as an aid in diagnosing the condition beneath the sound obtained.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Xenon Radioisotopes: Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Bromobenzenes: Derivatives of benzene in which one or more hydrogen atoms on the benzene ring are replaced by bromine atoms.Methyldimethylaminoazobenzene: A very potent liver carcinogen.p-Dimethylaminoazobenzene: A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Receptor, Serotonin, 5-HT1B: A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.Industry: Any enterprise centered on the processing, assembly, production, or marketing of a line of products, services, commodities, or merchandise, in a particular field often named after its principal product. Examples include the automobile, fishing, music, publishing, insurance, and textile industries.Tobacco Industry: The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Crk-Associated Substrate Protein: Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.Food Industry: The industry concerned with processing, preparing, preserving, distributing, and serving of foods and beverages.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.QuinoxalinesDimethylformamideElectrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Estranes: A group of compounds forming the nucleus of the estrogenic steroid family.Cyclic N-Oxides: Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Nitriles: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.

Identification and quantification of cocaine N-oxide: a thermally labile metabolite of cocaine. (1/1205)

In this article, we report the identification and quantitation of cocaine N-oxide (CNO), a thermally labile oxidative metabolite, from both animal and human samples. The concentration of CNO is similar to the concentrations of cocaine in the samples analyzed. The technique used for the determination of CNO in this study is liquid chromatography-electrospray ionization mass spectrometry, which is necessary because CNO is converted to cocaine upon heating. This includes simple heating of aqueous solutions to temperatures in excess of 100 degrees C and analysis by gas chromatography-mass spectrometry (GC-MS), in which CNO is converted to cocaine in the injection port. The thermal conversion of CNO to cocaine is estimated to cause an over-reporting of cocaine levels by 10-20% when using GC-MS.  (+info)

Localization and environment of tryptophans in soluble and membrane-bound states of a pore-forming toxin from Staphylococcus aureus. (2/1205)

The location and environment of tryptophans in the soluble and membrane-bound forms of Staphylococcus aureus alpha-toxin were monitored using intrinsic tryptophan fluorescence. Fluorescence quenching of the toxin monomer in solution indicated varying degrees of tryptophan burial within the protein interior. N-Bromosuccinimide readily abolished 80% of the fluorescence in solution. The residual fluorescence of the modified toxin showed a blue-shifted emission maximum, a longer fluorescence lifetime as compared to the unmodified and membrane-bound alpha-toxin, and a 5- to 6-nm red edge excitation shift, all indicating a restricted tryptophan environment and deeply buried tryptophans. In the membrane-bound form, the fluorescence of alpha-toxin was quenched by iodide, indicating a conformational change leading to exposure of some tryptophans. A shorter average lifetime of tryptophans in the membrane-bound alpha-toxin as compared to the native toxin supported the conclusions based on iodide quenching of the membrane-bound toxin. Fluorescence quenching of membrane-bound alpha-toxin using brominated and spin-labeled fatty acids showed no quenching of fluorescence using brominated lipids. However, significant quenching was observed using 5- and 12-doxyl stearic acids. An average depth calculation using the parallax method indicated that the doxyl-quenchable tryptophans are located at an average depth of 10 A from the center of the bilayer close to the membrane interface. This was found to be in striking agreement with the recently described structure of the membrane-bound form of alpha-toxin.  (+info)

Antioxidative activity of 4-oxy- and 4-hydroxy-nitroxides in tissues and erythrocytes from rats. (3/1205)

AIM: To compare the activities of antioxidation of 4-oxy- and 4-hydroxy-nitroxides in tissues and RBC from rats. METHODS: The homogenates of liver, heart, and kidneys of rats were used to determine malondialdehyde (MDA) formation using TBA colorimetric method. H2O2-caused hemolysis was measured spectrometrically. Superoxide anion from zymosan-stimulated neutrophils of rats was assayed by NBT reduction method. RESULTS: Nitroxide free radicals OTMPO and HTMPO inhibited MDA generation caused by .OH generation system (MIC 10.5 and 21 mumol.L-1, respectively), antagonized hemolysis induced by H2O2 (MIC: 338 and 168 mumol.L-1, respectively), but did not affect O2- formation from activated neutrophils. 1-Hydroxyl compounds OTMPOH and HTMPOH possessed similarly potent antilipoperoxidative activities. But nonfree radical OTMP and HTMP had no effect on peroxidation of tissues. CONCLUSION: Nitroxides exert their antilipoperoxidative effect by specifically scavenging .OH free radicals in biological system. Trapping of .OH free radicals by nitroxides is not by reduction of NO. group in nitroxides. Both NO. group and NOH group are essential active groups.  (+info)

Cycloheximide and 4-OH-TEMPO suppress chloramphenicol-induced apoptosis in RL-34 cells via the suppression of the formation of megamitochondria. (4/1205)

Toxic effects of chloramphenicol, an antibiotic inhibitor of mitochondrial protein synthesis, on rat liver derived RL-34 cell line were completely blocked by a combined treatment with substances endowed with direct or indirect antioxidant properties. A stable, nitroxide free radical scavenger, 4-hydroxy-2,2,6, 6-tetramethylpiperidine-1-oxyl, and a protein synthesis inhibitor, cycloheximide, suppressed in a similar manner the following manifestations of the chloramphenicol cytotoxicity: (1) Oxidative stress state as evidenced by FACS analysis of cells loaded with carboxy-dichlorodihydrofluorescein diacetate and Mito Tracker CMTH2MRos; (2) megamitochondria formation detected by staining of mitochondria with MitoTracker CMXRos under a laser confocal microscopy and electron microscopy; (3) apoptotic changes of the cell detected by the phase contrast microscopy, DNA laddering analysis and cell cycle analysis. Since increases of ROS generation in chloramphenicol-treated cells were the first sign of the chloramphenicol toxicity, we assume that oxidative stress state is a mediator of above described alternations of RL-34 cells including MG formation. Pretreatment of cells with cycloheximide or 4-hydroxy-2,2, 6,6-tetramethylpiperidine-1-oxyl, which is known to be localized into mitochondria, inhibited the megamitochondria formation and succeeding apoptotic changes of the cell. Protective effects of cycloheximide, which enhances the expression of Bcl-2 protein, may further confirm our hypothesis that the megamitochondria formation is a cellular response to an increased ROS generation and raise a possibility that antiapoptotic action of the drug is exerted via the protection of the mitochondria functions.  (+info)

EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction. (5/1205)

The search for effective iron chelating agents was primarily driven by the need to treat iron-loading refractory anemias such as beta-thalassemia major. However, there is a potential for therapeutic use of iron chelators in non-iron overload conditions. Iron can, under appropriate conditions, catalyze the production of toxic oxygen radicals which have been implicated in numerous pathologies and, hence, iron chelators may be useful as inhibitors of free radical-mediated tissue damage. We have developed the orally effective iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and demonstrated that it inhibits iron-mediated oxyradical formation and their effects (e.g. 2-deoxyribose oxidative degradation, lipid peroxidation and plasmid DNA breaks). In this study we further characterized the mechanism of the antioxidant action of PIH and some of its analogs against *OH formation from the Fenton reaction. Using electron paramagnetic resonance (EPR) with 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trap for *OH we showed that PIH and salicylaldehyde isonicotinoyl hydrazone (SIH) inhibited Fe(II)-dependent production of *OH from H2O2. Moreover, PIH protected 2-deoxyribose against oxidative degradation induced by Fe(II) and H2O2. The protective effect of PIH against both DMPO hydroxylation and 2-deoxyribose degradation was inversely proportional to Fe(II) concentration. However, PIH did not change the primary products of the Fenton reaction as indicated by EPR experiments on *OH-mediated ethanol radical formation. Furthermore, PIH dramatically enhanced the rate of Fe(II) oxidation to Fe(III) in the presence of oxygen, suggesting that PIH decreases the concentration of Fe(II) available for the Fenton reaction. These results suggest that PIH and SIH deserve further investigation as inhibitors of free-radical mediated tissue damage.  (+info)

Surface exposure of the methionine side chains of calmodulin in solution. A nitroxide spin label and two-dimensional NMR study. (6/1205)

Binding of calcium to calmodulin (CaM) causes a conformational change in this ubiquitous calcium regulatory protein that allows the activation of many target proteins. Met residues make up a large portion of its hydrophobic target binding surfaces. In this work, we have studied the surface exposure of the Met residues in the apo- and calcium-bound states of CaM in solution. Complexes of calcium-CaM with synthetic peptides derived from the CaM-binding domains of myosin light chain kinase, constitutive nitric-oxide synthase, and CaM-dependent protein kinase I were also studied. The surface exposure was measured by NMR by studying the effects of the soluble nitroxide spin label, 4-hydroxyl-2,2,6, 6-tetramethylpiperidinyl-1-oxy, on the line widths and relaxation rates of the Met methyl resonances in samples of biosynthetically 13C-methyl-Met-labeled CaM. The Met residues move from an almost completely buried state in apo-CaM to an essentially fully exposed state in Ca2+4-CaM. Binding of two Ca2+ to the C-terminal lobe of CaM causes full exposure of the C-terminal Met residues and a partial exposure of the N-terminal Met side chains. Binding of the three target peptides blocks the access of the nitroxide surface probe to nearly all Met residues, although the mode of binding is distinct for the three peptides studied. These data show that calcium binding to CaM controls the surface exposure of the Met residues, thereby providing the switch for target protein binding.  (+info)

Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity. (7/1205)

The periplasmic DMSO reductase from Rhodobacter sphaeroides f. sp. denitrificans has been expressed in Escherichia coli BL21(DE3) cells in its mature form and with the R. sphaeroides or E. coli N-terminal signal sequence. Whereas the R. sphaeroides signal sequence prevents formation of active enzyme, addition of a 6x His-tag at the N terminus of the mature peptide maximizes production of active enzyme and allows for affinity purification. The recombinant protein contains 1.7-1.9 guanines and greater than 0.7 molybdenum atoms per molecule and has a DMSO reductase activity of 3.4-3.7 units/nmol molybdenum, compared with 3.7 units/nmol molybdenum for enzyme purified from R. sphaeroides. The recombinant enzyme differs from the native enzyme in its color and spectrum but is indistinguishable from the native protein after redox cycling with reduced methyl viologen and Me2SO. Substitution of Cys for the molybdenum-ligating Ser-147 produced a protein with DMSO reductase activity of 1.4-1.5 units/nmol molybdenum. The mutant protein differs from wild type in its color and absorption spectrum in both the oxidized and reduced states. This substitution leads to losses of 61-99% of activity toward five substrates, but the adenosine N1-oxide reductase activity increases by over 400%.  (+info)

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. (8/1205)

Amyloid beta (Abeta) peptides play an important role in the pathogenesis of Alzheimer's disease. Free radical generation by Abeta peptides was suggested to be a key mechanism of their neurotoxicity. Reports that neurotoxic free radicals derived from Abeta-(1-40) and Abeta-(25-35) peptides react with the spin trap N-tert-butyl-alpha-phenylnitrone (PBN) to form a PBN/.Abeta peptide radical adduct with a specific triplet ESR signal assert that the peptide itself was the source of free radicals. We now report that three Abeta peptides, Abeta-(1-40), Abeta-(25-35), and Abeta-(40-1), do not yield radical adducts with PBN from the Oklahoma Medical Research Foundation (OMRF). In contrast to OMRF PBN, incubation of Sigma PBN in phosphate buffer without Abeta peptides produced a three-line ESR spectrum. It was shown that this nitroxide is di-tert-butylnitroxide and is formed in the Sigma PBN solution as a result of transition metal-catalyzed auto-oxidation of the respective hydroxylamine present as an impurity in the Sigma PBN. Under some conditions, incubation of PBN from Sigma with Abeta-(1-40) or Abeta-(25-35) can stimulate the formation of di-tert-butylnitroxide. It was shown that Abeta peptides enhanced oxidation of cyclic hydroxylamine 1-hydroxy-4-oxo-2,2,6, 6-tetramethylpiperidine (TEMPONE-H), which was strongly inhibited by the treatment of phosphate buffer with Chelex-100. It was shown that ferric and cupric ions are effective oxidants of TEMPONE-H. The data obtained allow us to conclude that under some conditions toxic Abeta peptides Abeta-(1-40) and Abeta-(25-35) enhance metal-catalyzed oxidation of hydroxylamine derivatives, but do not spontaneously form peptide-derived free radicals.  (+info)

*Organosulfur compounds

S-Oxides and S,S-dioxides of thiocarbonyl compounds[edit]. The S-oxides of thiocarbonyl compounds are known as thiocarbonyl S- ... The most common organosulfur compound present in all petroleum fractions is thiophene (C4H4S), a cyclic and aromatic liquid. In ... A sulfoxide, R−S(O)−R, is the S-oxide of a sulfide ("sulfide oxide"), a sulfone, R−S(O)2−R, is the S,S-dioxide of a sulfide, a ... These compounds are well known with extensive chemistry, e.g., see syn-propanethial-S-oxide and sulfene. ...

*Wolff rearrangement

Small and medium cyclic substrates are constrained in the s-cis conformation. When the α-diazo ketone is in the s-cis ... In this last case, the reaction is sensitive to the transition metal; silver (I) oxide or other Ag(I) catalysts work well and ... Another common use is in ring-contraction methods; if the α-diazo ketone is cyclic, the Wolff rearrangement results in a ring- ... However, for all substrates except cyclic α-diazo ketones that exist solely in the s-cis conformation, products come from a ...

*Curtin-Hammett principle

3.0.CO;2-A. Y. Shvo; E.D. Kaufman (1972). "Configurational and conformational analysis of cyclic amine oxides". Tetrahedron. 28 ... A Curtin-Hammett scenario was invoked to explain selectivity in the syntheses of kapakahines B and F, two cyclic peptides ... a cyclic hexapeptide with an .alpha.-carboline ring system from the marine sponge Cribrochalina olemda". Journal of the ...

*Silicate

The great majority of the silicates are oxides, but hexafluorosilicate ([SiF6]2−) and other anions are also included. " ... Important members are the cyclic and single chain silicates {[SiO3]2−}n and the sheet-forming silicates {[SiO2.5]−}n. Silicates ...

*4-PPBP

... decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP ... 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response ... "Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4- ... "Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 ...

*Paraxanthine

... inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice". ... Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ...

*Pyrithione

Substituted 2-Bromopyridine-N-oxides and Their Conversion to Cyclic Thiohydroxamic Acids". J. Am. Chem. Soc. 72 (10): 4362-4364 ... Another approach involves treating the same starting N-oxide with thiourea to afford pyridyl-2-isothiouronium chloride N-oxide ... Oxidation to the N-oxide can then be undertaken. Pyrithione is found as a natural product in the Allium stipitatum plant, an ... The preparation of pyrithione was first reported in 1950 by Shaw and was prepared by reaction of 2-chloropyridine N-oxide with ...

*Perfluoroether

Thus tetrafluoroethyene oxide and hexafluoropropylene oxide are two of the simplest cyclic perfluoroethers. It is a precursor ... Krytox is a grease generated by the polymerization of hexafluoropropylene oxide. Their chemical formula is F−(CF(CF3)−CF2−O)n− ... More interesting and more useful are the cyclic ethers, especially, the epoxides. ...

*Louis Ignarro

While studying cyclic GMP, Ignarro read a paper by Ferid Murad, who demonstrated that nitric oxide elevates cyclic GMP levels. ... He is the founder of the Nitric Oxide Society, and founder and editor-in-chief of Nitric Oxide Biology and Chemistry.[3] ... Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. ... CIBA Award for Hypertension Research for Discovery of the Roles of Nitric Oxide and Cyclic GMP in Vascular Function. Shared ...

*Nitrosyl chloride

NOCl converts some cyclic amines to the alkenes. For example, aziridine reacts with NOCl to give ethene, nitrous oxide and ... The oxide is converted to caprolactam, a precursor to Nylon-6. Nitrosyl chloride is very toxic and irritating to the lungs, ... Ketenes also add NOCl, giving nitrosyl derivatives: H2C=C=O + NOCl → ONCH2C(O)Cl Propylene oxide reacts with NOCl to give an α- ... NOCl NOCl forms by the direct combination of chlorine and nitric oxide; This reaction reverses above 100 °C. Cl2 + 2 NO → 2NOCl ...

*Jean'ne Shreeve

Gupta, Om Dutt; Kirchmeier, Robert L.; Shreeve, Jean'ne M. (1990). "Reactions of Trifluoroamine Oxide: A Route to Acyclic and ... Cyclic Fluororamines, and N-Nitrosoamines". Journal of the American Chemical Society. 112: 2383. Kitazume, Tomoya; Shreeve, ...

*Phenylsilane

For example, cyclic chiral tertiary phosphine oxides can be reduced to cyclic tertiary phosphines. Phenylsilane can also be ... 4 Phenylsilane can be used to reduce tertiary phosphine oxides to the corresponding tertiary phosphine. P(CH3)3O + PhSiH3 --> P ...

*Riociguat

The first nitric oxide (NO) independent, haem-dependent sGC stimulator, YC-1, a synthetic benzylindazole derivative, was ... NO binds to soluble guanylate cyclase (sGC) and mediates the synthesis of the secondary messenger cyclic guanosine ... Giaid A, Saleh D (July 1995). "Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary ... In healthy individuals nitric oxide (NO) acts as a signalling molecule on vascular smooth muscle cells to induce vasodilation. ...

*PIGF

"Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release". American Journal of ...

*Ether

A cyclic ether and high-boiling solvent (b.p. 101.1 °C). Tetrahydrofuran (THF) A cyclic ether, one of the most polar simple ... Polyethylene oxide (PEO) or polyoxyethylene (POE). Ring-opening polymerization of ethylene oxide. -CH2CH2O-. Carbowax from Dow ... Polypropylene oxide (PPOX) or polyoxypropylene (POP). Anionic ring-opening polymerization of propylene oxide. -CH2CH(CH3)O-. ... Ethylene oxide Also the simplest epoxide. Dimethyl ether An aerosol spray propellant. A potential renewable alternative fuel ...

*CAMK1

Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I". Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide ... Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin- ... 1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597-602. doi:10.1074/ ...

*12-Crown-4

It is a cyclic tetramer of ethylene oxide which is specific for the lithium cation. Its point group is S4. The dipole moment of ...

*CAMK2A

Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein ...

*CAMK4

Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV". Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide ... Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin- ... 1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597-602. doi:10.1074/ ...

*Shewanella woodyi

"Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis inShewanella woodyi". Biochemistry. 51 (10): 2087-2099. doi: ...

*Thromboregulation

"Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane by cyclic GMP-dependent protein kinase ... inhibition of cyclic AMP breakdown by cyclic GMP". Molecular Pharmacology. 37 (5): 671-681. Siess, Wolfgang; Eduardo, Lapetina ... Nitric oxide (NO) stimulates cGMP production and therefore the activation cGMP-dependent protein kinase (G kinase). This kinase ... cAMP, cyclic adenosine monophosphate, phosphorylate messengers via protein kinase A (PKA). These signaling elements include ...

*Enone

Cyclic enones can be prepared via the Pauson-Khand reaction. Enones undergo many kinds of reactions. They are electrophilic at ... Some commercially significant enones are produced by condensations of acetone, e.g. mesityl oxide and isophorone. In the Meyer- ...

*Platelet

Palmer RM; Ferrige AG; Moncada S (1987). "Nitric oxide release accounts for the biological activity of endothelium-derived ... Resting platelets maintain active calcium efflux via a cyclic AMP activated calcium pump. Intracellular calcium concentration ... Thrombus formation on an intact endothelium is prevented by nitric oxide, prostacyclin, and CD39. Endothelial cells are ... The intact endothelial lining inhibits platelet activation by producing nitric oxide, endothelial-ADPase, and PGI2 ( ...

*Adrenomedullin

Stimulation by AM of its receptor increases production of both cyclic AMP (cAMP) and nitric oxide. Before the discovery of the ...

*List of phytochemicals in food

Syn-propanethial-S-oxide cut onions. Betacyanins beets, chard, Amaranthus tricolor. betanin isobetanin probetanin neobetanin ... Chlorophyllin Saturated cyclic acids Phytic acid (inositol hexaphosphate) cereals, nuts, sesame seeds, soybeans, wheat, pumpkin ...

*Superalloy

"Characterisation of a cyclic displacement instability for a thermally grown oxide in a thermal barrier coating system". Acta ... This means that the coatings form an outer layer of chromium oxide (chromia), and a secondary aluminum oxide (alumina) layer ... The alumina controls oxidation mechanisms by limiting oxide growth by self-passivating. The yttrium enhances the oxide ... The Al and Cr form oxide layers that passivate the surface and protect the superalloy from further oxidation while B and Y are ...

*Oxazoline

Kobayashi, Shiro; Uyama, Hiroshi (15 January 2002). "Polymerization of cyclic imino ethers: From its discovery to the present ... owing to the large amounts of triphenylphosphine oxide produced, the method is not ideal for large-scale reactions. The use of ...

*Peroxy acid

Certain cyclic ketones are converted to the ring-expanded esters using peracids in a Baeyer-Villiger oxidation. They are also ... used for the oxidation of amines and thioethers to amine oxides and sulfoxides. The laboratory applications of the valued ... RCO2H This method is popular for converting cyclic anhydrides to the corresponding monoperoxyacids, for example ...
[150 Pages Report] Check for Discount on 2016 4-Acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl (CAS 14691-89-5) Industry Market Report report by Prof Research. The Global and Chinese 4-Acetylamino-2,2,6,6-...
Both the blood pressure and the renal vasculature of the SHR have an increased responsiveness and sensitivity to the vasodilation produced by scavenging of O2−. Tempol, a membrane-permeable SOD mimetic, normalized MAP and RVR of SHR. Because the antihypertensive response was blocked by NO synthesis inhibition, it must depend on NO. O2− also appears to be important in the longer-term control of blood pressure in SHR. These results suggest that SHR have increased O2− activity that contributes to their hypertension. In these studies, the effect of tempol on RVR may have been secondary to its effect on blood pressure with engagement of renal autoregulation.. O2− is generated and acts both extracellularly and intracellularly, where it can have harmful effects including lipid peroxidation, protein aggregation, and DNA destruction.25 Previous investigators have used scavengers of O2− to reduce inflammation,26 atherosclerosis,27 and ischemia/reperfusion injury.28 Because native SOD has limited ...
We conducted the present study based on our earlier findings that the stable nitroxide tempol when administered i.p. led to radioprotection of murine salivary glands. We have examined the effects of tempol dose, the route of tempol administration, and the timing of tempol administration in this model. In the previous study, the dose used (275 mg/kg tempol) was 75% of the LD50 when administered i.p. Thus, we initially preformed studies to examine the tempol dose dependence of salivary gland radioprotection. We found equivalent irradiation protection of salivary output after tempol doses of 275 and 137.5 mg/kg body weight. There was no significant protection at lower doses.. Next, we evaluated the significance of the time of tempol i.p. administration. Of the three timepoints tested, only administration 10 minutes before irradiation was effective in protecting salivary gland function. Neither administration 5 minutes before irradiation nor 10 minutes after irradiation was useful. We speculate that ...
Up to the interim analysis, patients are randomized to one of the Otamixaban arms or the control arm (UFH + Eptifibatide). Then after interim analysis, patients will be randomized to the continued Otamixaban arm (per Data Monitoring Committee (DMC) decision based on interim analysis results) or the control arm (UFH + Eptifibatide). Except the DMC, all participants will remain blinded to this decision until the end of study.. The total duration of the study period per subject will range between 30 days and 180 days. Study end date being the Day 30 visit of the last randomized patient, follow up will be until Day 180 or study end date whichever comes first. ...
Up to the interim analysis, patients are randomized to one of the Otamixaban arms or the control arm (UFH + Eptifibatide). Then after interim analysis, patients will be randomized to the continued Otamixaban arm (per Data Monitoring Committee (DMC) decision based on interim analysis results) or the control arm (UFH + Eptifibatide). Except the DMC, all participants will remain blinded to this decision until the end of study.. The total duration of the study period per subject will range between 30 days and 180 days. Study end date being the Day 30 visit of the last randomized patient, follow up will be until Day 180 or study end date whichever comes first. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The onset of metastases dramatically changes the prognosis of prostate cancer patients, identifying increased morbidity along with a extreme fall in survival expectancy. capability of prostate tumor cells to migrate in bone tissue marrow also to determine blended osteoblastic/osteolytic lesions. As Srebf1 expected by the achievement of current targeted therapy directed to block bone tissue resorption, an improved knowledge of molecular affinity between prostate tumor and bone tissue microenvironment will permit us to get rid of bone tissue metastasis also to improve prognosis of prostate tumor sufferers. 1. Launch Although just 5% of sufferers identified as having prostate tumor (PCa) possess metastatic disease, a lot more than 60% of these who perish from PCa possess metastases disseminated in faraway sites. In early diagnosed, low quality PCa, the operative, rays, and hormone remedies assure an extended life expectancy. Nevertheless the risk for Otamixaban metastatic disease significantly ...
TY - JOUR. T1 - Blockade of ATP-sensitive potassium channels prevents the attenuation of the exercise pressor reflex by tempol in rats with ligated femoral arteries. AU - Yamauchi, Katsuya. AU - Stone, Audrey J.. AU - Stocker, Sean D.. AU - Kaufman, Marc P.. PY - 2012/8/1. Y1 - 2012/8/1. N2 - We reported previously that tempol attenuated the exercise pressor and muscle mechanoreceptor reflexes in rats whose femoral arteries were ligated, whereas tempol did not attenuate these reflexes in rats whose femoral arteries were freely perfused. Although the mechanism whereby tempol attenuated these reflexes in rats whose femoral artery was ligated was independent of its ability to scavenge reactive oxygen species, its nature remains unclear. An alternative explanation for the tempol-induced attenuation of these reflexes involves ATP-sensitive potassium channels (K Atp) and calcium-activated potassium channels (BK Ca), both of which are opened by tempol. We tested the likelihood of this explanation by ...
The effect of grape seed extract (GSE) on the lipid peroxidation of rat heart mitochondria was studied using the spin trapping agent α-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN) with electron spin resonance (ESR) spectrometer. Two fatty acid spin labels, 5-doxyl-stearic acid (5-DOXYL) and 16-doxyl-stearic acid (16-DOXYL) were used to study the effect of GSE on mitochondrial membrane fluidity. The results showed that the GSE could scavenge the lipid free radicals generated from the mitochondria of rat heart, and protect the mitochondrial membranes damaged by lipid peroxidation. Both the scavenging effect and the protective effect are better in water phase than in lipid phase. And the data indicate that perhaps trimers and other polymers have better scavenging effect on lipid free radicals than monomers.
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We examined whether a nitric oxide scavenger, 2-(4-carboxypheny l)-4,4,5,5-tetramethy l-imidazo line- l-oxy l-3-oxide (carboxy- PTIO), cou ld offer neuroprotective actions and improve cerebra l energy
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What role does tempo training play in achieving fitness goals? Check out this article and get up to speed on the latest tempo training research.
[2,6-Dibromopyridine N-Oxide] [25373-69-7] | Buy and find out price and availability, MSDS, properties of TCIs high quality specialty chemicals.
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The present invention relates to a kind of preparation method of 1,2,3,3 tetramethyl indoles of 6 nitro, with 1,2,3,3 tetramethyl indoles are raw material, using sulfuric acid as solvent, using the nitration mixture of certain concentration as nitrating agent, nitration mixture is added dropwise within a certain period of time and carries out nitration reaction 6 nitros 1,2,3 of generation, 3 tetramethyl indoles, reaction solution is diluted in a certain amount of frozen water and is filtered to remove byproduct, and the reaction solution after filtering obtains 6 nitros 1 by anti-tune, 2,3,3 tetramethyl indoles.Present invention process is simple, product post processing is easy, environmental pollution is small, 6 nitros 1,2 being prepared, 3,3 tetramethyl indoles product quality qualities are high, and stability is good, and obtained product is in addition to it can be used for general applications, the preparation of high-end resin is can be also used for, is a kind of method of suitable
The mechanism of the oxidation of primary and secondary alcohols by the oxoammonium cation derived from 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been investigated computationally at the B3LYP/6-31+G* level, along with free energies of solvation, using a reaction field model. In basic solution, the reaction involves formation of a complex between the alkoxide anion and the oxoammonium cation in a pre-oxidation equilibrium wherein methoxide leads to a much larger formation constant than isopropoxide. The differences in free energy of activation for the rate-determining hydrogen transfer within the pre-oxidation complexes were small; the differences in complex formation constants lead to a larger rate of reaction for the primary alcohol, as is observed experimentally. In acidic solution, rate-determining hydrogen atom transfer from the alcohol to the oxoammonium cation had a large unfavorable free energy change and would proceed more slowly than is observed. A more likely path involves a hydride
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide: partial structure given in first source; endothelium-derived relaxing factor antagonist
The acute oral toxicity of N-Butyl-2,2,6,6-tetramethylpiperidine-4-amine was investigated following administration of a single dose to the rat by gavage. A single group of 3 female animals was dosed at a level of 2000 mg/kg. All animals died within 4 hours of dosing. Reduced activity, hunched posture, lethargy and closed eyes were observed prior to death. An additional group of 3 female animals was then dosed at 300 mg/kg and observed for a period of 14 days. No mortality occurred. Clinical signs included piloerection, reduced activity, hunched posture and semi-closed eyes, which were observed on the day of dosing. Recovery had occurred by Day 2. A group of 3 female animals was subsequently dosed at the same level (300 mg/kg) with the same result. Changes in body weight observed in treated animals were not remarkable. A reduced body weight gain or a body weight loss was noted at the end of the first week of the study, but recovery was observed at the end of the study. No abnormalities were ...
adducts with a higher lifetime. (106cells/mL) were incubated for 10 min at 37 °C in Global Veterinaria, 15 (1): 72-81, 2015 darkness with honey at final concentrations of 2, 5, 10 and complex spectra with an increased intensity of the four- 20% (w/v) for each honey sample and then activated for line ESR signal attributed to the DMPO-OH adducts (sign 30 min at 37 °C once again in darkness with PMA at the Ø spectrum 2in Fig. 1b) and a new signal (sign * spectrum final concentration of 0.8 µM. After activation, the cell 2in Fig 1b). Similar data were obtained with MH, but are suspensions were centrifuged for 10 min (450 g) and the not presented here. When, 5% of NH (w/v) were added to supernatants were collected. To measure the total MPO the complete system, there was no real modification of the released by activated neutrophils in the extra-cellular shape of the ESR signal intensity attributed to DMPO-OH milieu, an original Equine MPO ELISA assay designed by adducts and the new signal as shown ...
Avantis nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are
Structure, properties, spectra, suppliers and links for: (1R,2S,4S,7S,8S,9S,10R,11S,12S,13R,17R,18S)-8,10-Dihydroxy-1,5,9,18-tetramethyl-16,20-dioxahexac.
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Tempo running is a great way to improve your running economy, and make you a better more efficient runner. However, many people do not know how to run a tempo run properly. Oftentimes, they run the tempo to hard leaving them overly tired. Tempo running is something that should be...
Rh(III)-Catalyzed Direct C8-Arylation of Quinoline N-Oxides using Diazonaphthalen-2(1H)-ones: A Practical Approach towards 8-azaBINOL ...
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Fuel cells are disclosed that operate directly on fuel streams comprising tetramethyl orthocarbonate in which tetramethyl orthocarbonate is directly oxidized at the anode and, more particularly, to solid polymer fuel cells operating directly on liquid fuel streams comprising tetramethyl orthocarbonate. Also disclosed are methods relating thereto.
The BIU EPR center is equipped with the state of the art instrumentation .. The equipments that we have can provide the resources necessary for contemporary research of paramagnetic metals (i.e.: Cu(II), Mn(II/III/IV), Fe(II/III) etc), organic radicals, Oxygen and Nitroxide radicals in biology research, oxidative stress, antioxidants, bioinorganic complexes, changes in structure of paramagnetic electrode, identification and structure of paramagnetic nano particles, comparing size of nano particles, protein having paramagnetic atoms and structural biology. The EPR research center allows a number of groups from Chemistry, Physics and Biology from BIU in which several research projects are being performed.. EMX:. We have been using currently the Bruker EMX EPR 100d X-band Spectrometer. This spectrometer is a continuous wave (CW) spectrometer, operating at 9.5 GHz, 30 mm with center of magnetic field at around 3300 G. It can operate between 150 K to 400 K and is been used for spin trap EPR, metal ...
Part I; DNA and Higher Order Cell Systems The effects of a range of nitroxides on the radiation damage routes in frozen aqueous DNA have been studied by comparison with nitroxide free systems. The results show that nitroxides affect the yield of both primary and secondary radicals in this system. The differences between the effects of the nitroxides studied are attributed to steric effects. A range of spin-labelled polyanmionium cations (PACs) have been used to probe the motion of PACs when they are complexed with DNA. The results suggest that PACs experience virtually free movement along the DNA backbone. The effects of one of these spin-labelled PACs on irradiated frozen aqueous DNA have been studied. The results show that constraining the nitroxide group to be close to the DNA by attaching it to a PAC increases the effect of the nitroxide on irradiated DNA at low temperatures. At higher temperatures the spin-labelled PAC is less effective and it is proposed that this is due to less efficient ...
Endothelial dysfunction, in part caused by oxidative inactivation of nitric oxide (NO•) by excess level of O2•-, contributes to various cardiovascular diseases including diabetes (DM). Extracellular superoxide dismutase (ecSOD), a secretory Cu enzyme, is the major antioxidant enzyme against O2•- in the vascular extracellular space. However, role of endogenous ecSOD in diabetic vessels remains unclear. Here we show that specific activity of ecSOD, but not cytosolic Cu/Zn SOD, is decreased by 35% in aortas of streptozotocin (STZ)-induced DM mice. This is associated with significantly increased L-NAME-sensitive O2•- production (P,0.05) and increased 3-nitrotyrosine (3-NT) level, a marker of ONOO-, implicating eNOS uncoupling. Functionally, acetylcholine-induced NO-mediated vasorelaxation is impaired (P,0.05) in mesenteric arteries of DM, which is rescued by SOD mimetic tempol or adenovirus mediated gene transfer of ecSOD. Importantly, supplementation of catalytic cofactor copper (Cu) ...
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with imino or oxy linked to aminoxyl-containing radical to form an amide linkage or an oxycarbonyl linkage at the chain end of biocompatible polymers or copolymers to the aminoxyl-containing radical. Preferred starting material polymers and copolymers are prepared from the hydroxy alkyl carboxylic acid monomers glycolic acid and lactic acid. Preferred aminoxyl-containing radical is 2,2,6,6-tetramethylpiperidine-1-oxy. Product polymers are useful for aminoxyl-containing radical treatment of tumors, and to increase the efficiency of chemotherapy and ionizing radiation therapy of tumors and for the reconstruction of injured, diseased, or aged human blood vessels.
0036] In certain embodiments, sPLA2 inhibitors for use in the current invention are selected from the group consisting of: {9-[(phenyl)methyl]-5-carbamoylcarbazol-4-yl}oxyacetic acid; 9-benzyl-5,7-dimethoxy-1,2,3,4-tetrahydrocarbazole-4-carboxylic acid hydrazide; 9-benzyl-5,7-dimethoxy-1,2,3,4-tetrahydrocarbazole-4-carboxamide; [9-benzyl-4-carbamoyl-7-methoxy-1,2,3,4-tetrahydrocarbazol-5-yl]oxyacetic acid; [9-benzyl-4-carbamoyl-7-methoxycarbazol-5-yl]oxyacetic acid; methyl[9-benzyl-4-carbamoyl-7-methoxycarbazol-5-yl]oxyacetic acid; 9-benzyl-7-methoxy-5-cyanomethyloxy-1,2,3,4-tetrahydrocarbazole-4-carboxa- mide; 9-benzyl-7-methoxy-5-(1H-tetrazol-5-yl-methyl)oxy)-1,2,3,4-tetrahydr- ocarbazole-4-carboxamide; {9-[(phenyl)methyl]-5-carbamoyl-2-methyl-carbazol-4-yl}oxyacetic acid; {9-[(3-fluorophenyl)methyl]-5-carbamoyl-2-methylcarbazol-4-yl}oxyacetic acid; {9-[(3-methylphenyl)methyl]-5-carbamoyl-2-methylcarbazol-4-yl}oxyac- etic acid; {9-[(phenyl)methyl]-5-carbamoyl-2-(4-trifluoromethylphenyl)-car- ...
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Electron paramagnetic resonance (EPR) spectroscopy is an unambiguous method to measure free radicals. The use of selective spin probes...
1226995-21-6|2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)QUINOLINE|A&J Pharmtech Co. Ltd.|2-(tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline
declare variable $timesequence := fn:doc("temp_events.xml"); let $MAX_DIFF := 2 for sliding window $w in $timesequence/stream/event start $s_curr at $s_pos previous $s_prev when ($s_curr/@time ne $s_prev/@time) or (empty($s_prev)) only end next $e_next when $e_next/@time - $s_curr/@time gt $MAX_DIFF return avg( $w/@temp ) %%% declare variable $timesequence := fn:doc("temp_events.xml"); let $SMOOTH_CONST := 0.2 for sliding window $w in $timesequence/stream/event start at $s_pos when true() only end at $e_pos when $e_pos - $s_pos eq 2 return round-half-to-even($SMOOTH_CONST * data($w[3]/@temp) + (1 - $SMOOTH_CONST) * ( $SMOOTH_CONST * data($w[2]/@temp) + (1 - $SMOOTH_CONST) * data($w[1]/@temp) ), 2) %%% declare variable $seq := fn:doc("temp_events.xml"); for sliding window $w in $seq/stream/event start $s_curr when fn:true() only end next $next when $next/@time > $s_curr/@time + 3 return let $avg := fn:avg($w/@temp) where $avg * 2 lt xs:double($next/@temp) or $avg div 2 gt xs:double($next/@temp) ...
2-[4-[4-(6-Carbamoyl-3-methylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid | C20H23N3O3 | CID 44126032 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule n-[(2s)-1-(2-carbamoyl-1,3-thiazolidin-3-yl)-4-methyl-1-oxo-2-pentanyl]-l-prolinamide (C15H26N4O3S) from the PQR.
Structure, properties, spectra, suppliers and links for: 2-Methyl-3-[(2E,7S,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-1,4-naphthoquinone.
MolCore offers CAS No.1375708-04-5, 6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine for your research needs.Find product specific information including MFCD22574004,1375708-04-5 MSDS,Price,Custom Synthesis.
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Electron, Electron Paramagnetic Resonance, Paramagnetic Resonance, Report, Work, Spectroscopy, Crystallin, Lysozyme, Membrane, Spin Labels, Water, Proteins, Cataract, Dissociation, Heat, Shock, ATP, Binding Site, Hydrolysis, Distance
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Krauze A.A.; Odynets A.G.; Verreva A.A.; Germane S.K.; Kozhukhov A.N.; Dubur G.Ya. Synthesis and hepatoprotectant activity of 5-carbamoyl- and 5-acetyl-2-alkylthio-6-methyl-4-aryl-3-cyano-1,4-dihydropyridines. Pharm Chem J 1991, 25(7), 477-481 ...
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Page contains details about bis[4-(9,9-dimethyl-9,10-dihydroacridin-10-yl)phenyl]sulfone-doped 4-diphenylphosphinoylspiro[fluorene-9,9-xanthene] film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
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1,1-dimethyl-1,2,2a,3,4,5-hexahydroacenaphthylene - chemical structural formula, chemical names, chemical properties, synthesis references
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The electrochemical properties of twenty 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives with varying degrees of cytotoxic activity were investigated in dimethylformamide (DMF) using cyclic voltammetry and first derivative cyclic voltammetry. With one exception, the first reduction of these compounds was found to be reversible or quasireversible and is attributed to reduction of the N-oxide moiety to form a radical anion. The second reduction of the diazine ring was found to be irreversible. Compounds containing a nitro group on the 3-phenyl ring also exhibited a reduction process that may be attributed to that group. There was good correlation between molecular structure and reduction potential, with reduction being facilitated by an enhanced net positive charge at the electroactive site created by electron withdrawing substituents. Additionally, the reduction potential was calculated using two common basis sets, 6-31g and lanl2dz, for five of the test molecules. There was a strong
Reports, articles and other documents harvested from the Office of Scientific and Technical Information.. Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.. ...
Preliminary Study on Electron Paramagnetic Resonance(EPR) Signal Properties of Mobile Phone Components for Dose Estimation in Radiation Accident - Radiation accident;Electron spin resonance;Electron paramagnetic resonance;Dosimetry;
2,6-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 269410-25-5 safety info, 2,6-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL chemical safety search, Chemical 2,6-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL safety technical specifications ect.
Structural changes of fibrils and fibril aggregates in the fibre wall were studied after oxidation of the cellulose by 2,2,6,6-tetramethyl-1-piperidinyloxy to high charge densities (highest charge density: 1300 μeq/g). The increase in pore volume was measured by mini-WRV at two different pH levels, and the supramolecular structure in the fibre wall in terms of aggregate size, specific surface area and average pore size was measured by solid state NMR, DVS desorption and BET N2 gas adsorption. A structural change in the arrangement of the fibrils inside the fibril aggregates was observed although the oxidation did not lead to a complete liberation of individual fibrils, i.e. they still exist as an aggregated structure after oxidation. Theoretical estimates suggest that the electrostatic repulsion energy connected with the increase in surface charge of the fibrils can be sufficient to gradually separate the fibrils enough to expose all fibril surfaces to oxidation chemicals.. ...
The biodegradation behavior of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized cellulose fibers (TOCs) suspended in water and TEMPO-oxidized cellulose nanofibrils (TOCNs) dispersed in...
Detail záznamu - Threshold Photoelectron Spectroscopy of the Methyl Radical Isotopomers, CH3, CH2D, CHD2 and CD3: Synergy between VUV Synchrotron Radiation Experiments and Explicitly Correlated Coupled Cluster Calculations - Detail záznamu - Knihovna Akademie věd České republiky
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol chemical properties, What are the chemical properties of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 269409-70-3, What are the physical properties of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol ect.
Shangyu Catsyn Co., Ltd. Cas 14768-15-1,Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)gadolinium(III);GADOLINIUM III 2,2,6,6-TETRAMETHYLHEPTANEDIONATE;GADOLINIUM(III)-DPM;GD(TMHD)3;TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)GADOLINIUM;TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)GADOLINIUM(III);SC11006.
A : U:/TEMP/TEMP/A : U:/TEMP/TEMP/A/Test01.txt, Use of uninitialized value $file in concatenation (.) or string at ... + line 17. D : U:/TEMP/TEMP/D : , C : U:/TEMP/TEMP/C : U:/TEMP/TEMP/C/Test03.txt, Use of uninitialized value $file in concatenation (.) or string at ... + line 17. E : U:/TEMP/TEMP/E : , B : U:/TEMP/TEMP/B : U:/TEMP/TEMP/B/Test02.txt ...
Spin Labels: Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
Tkach, I.; Pornsuwan, S.; Höbartner, C.; Wachowius, F.; Sigurdsson, S.; Baranova, T. Y.; Diederichsen, U.; Sicoli, G.; Bennati, M.: Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation. Physical Chemistry Chemical Physics 15 (10), S. 3433 - 3437 (2013 ...
You are viewing an interactive 3D depiction of the molecule (1s,2r,3s,5s,6s,16e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2s)-2-[methyl(propionyl)amino]propanoate (C35H48ClN3O10) from the PQR.
Record for 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine, CAS Number 944401-55-2, MDL Number MFCD1807255.
html, ,head,,basefont face="Arial",,/head, ,body, ,h2,Temperature Converter,/h2, ,?php if($submit) { // data type conversion setType($temp,"integer"); $myClass = new Java("Temperature"); if($units == "celsius" && $temp != "") { // use the Celsius functions $myClass-,setCelsius($temp); // print result echo $myClass-,getCelsius()," ,sup,o,/sup, Celsius is ",$myClass-,convertCelsiusToFahrenheit($myClass-,getCelsius())," ,sup,o,/sup, Fahrenheit."; } else if($units == "fahrenheit" && $temp != "") { // use the Fahrenheit functions $myClass-,setFahrenheit($temp); // print result echo $myClass-,getFahrenheit() , " ,sup,o,/sup, Fahrenheit is ", $myClass-,convertFahrenheitToCelsius($myClass-,getFahrenheit()) , " ,sup,o,/sup, Celsius."; } else { echo "Please enter a valid temperature and scale"; } } else { ?, ,form action=",? echo $PHP_SELF; ?," method="post", ,input type ="text" name="temp" size="4″ maxlength="4″, ,select name="units", ,option value="celsius",Celsius,/option, ,option ...
Présentation de Daniel Kaplan dans le cadre des Jeudis du Temps organisés par le Bureau des Temps de Rennes, le 17 avril 2014. Sur la base des travaux de le…
Il tempo a Melena del Sur, Cuba per 7,14 giorni, la mappa del tempo, la cronologia meteorologica, il clima orario, il clima, lastronomia, lindice UV, il tempo sui resort, le migliori destinazioni per la ricreazione e molto altro.
Go by feel on your tempos. As Tinman says, your HR Max varies and you have no way of knowing on any given workout what it will be. But your body knows when you are running a tempo too fast cause you get out of breath rather quickly. And...there is a bit of wiggle room on those tempos anyway. If you run one a little too fast or a little too slow on any given day you will still be getting in a solid workout. You seem to be obsessed with precision in your training...just get out and make it happen ...
Go by feel on your tempos. As Tinman says, your HR Max varies and you have no way of knowing on any given workout what it will be. But your body knows when you are running a tempo too fast cause you get out of breath rather quickly. And...there is a bit of wiggle room on those tempos anyway. If you run one a little too fast or a little too slow on any given day you will still be getting in a solid workout. You seem to be obsessed with precision in your training...just get out and make it happen ...
Blog on 2,2,2-Trifluoro-N-4-pyridinyl-acetamide N-Oxide biochemical product: The 2,2,2-Trifluoro-N-4-pyridinyl-acetamide N-Oxide n/a (Catalog #MBS6070459) is a Biochemical and is int...
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Assesses the effects of vehicle age, operational tempo (OPTEMPO), deployment location, and reset on the mission-critical failures and maintenance costs of selected Army vehicle fleets.
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The film reminds us of just how difficult it can be to find ones own tempo amidst radical changes caused by unjust circumstances.
TY - JOUR. T1 - Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. AU - McPhail, D B AU - Hartley, R C AU - Gardner, P T AU - Duthie, G G. PY - 2003/3/12. Y1 - 2003/3/12. N2 - dThere is current interest in the use of naturally occurring flavonoids as antioxidants for the preservation of foods and the prevention of diseases such as atherosclerosis and cancers. To establish the molecular characteristics required for maximum antioxidant activity, electron spin resonance (ESR) spectroscopy has been used to determine the stoichiometry and kinetics of the hydrogen-donating ability of 15 flavonoids and D-alpha-tocopherol to galvinoxyl, a resonance-stabilized, sterically protected aryloxyl radical. The second-order reaction rates, which will be governed by O-H bond dissociation energies, were myricetin , morin , quercetin , fisetin similar to catechin , kaempferol similar to luteolin , rutin , D-alpha-tocopherol , taxifolin , ...
en] The C-phenyl-N-tert-butylnitrone/azobisisobutyronitrile pair is able to impart control to the radical polymerization of n-butyl acrylate as long as a two-step process is implemented, that is, the prereaction of the nitrone and the initiator in toluene at 85 degrees C for 4 h followed by the addition and polymerization of n-butyl acrylate at 110 degrees C. The structure of the in situ formed nitroxide has been established from kinetic and electron spin resonance data. The key parameters (the dissociation rate constant, combination rate constant, and equilibrium constant) that govern the process have been evaluated. The equilibrium constant between the dormant and active species is close to 1.6 x 10(-12) mol L-1 at 110 degrees C. The dissociation rate constant and the activation energy for the C-ON bond homolysis are 1.9 x 10(-3) s(-1) and 122 +/- 15 kJ mol(-1), respectively. The rate constant of recombination between the propagating adical and the nitroxide is as high as 1.2 x 10(9) L mol(-1) ...
0138]Synthesis of 4-[(5-aminopentyl)carbonylamino]-2,2,6,6-tetramethylpiperidine-1-oxyl. Mixture of 1.31 g (10 mM) of 6-aminocaproic acid and 4.5 ml of trifluoroacetic anhydride was heated for 2 h at 80° C. in soldered ampoule. Volatile components of the reaction mixture were evaporated at reduced pressure. The residual liquid consisted mainly of bis-trifluoroacetylated 6-aminocaproic acid. To achieve hydrolysis of mixed anhydride function of this intermediate, 0.25 ml (14 mM) of water was added to it with ice cooling. The solution was left for 1 h at ˜20° C. and after that it was azeotroped with three 10 ml portions of dry benzene. The yield of 6-(trifluoroacetylamino)caproic acid was 2.27 g, mp 83° C. It was dissolved in 10 ml of ethyl acetate and triethylamine (1.39 ml, 10 mM) and ethyl chloroformate (0.96 ml, 10 mM) were added sequentially at ice bath cooling and stirring. After stirring for 20 min at the same cooling, solution of 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (1.71 g, 10 ...
TY - JOUR. T1 - Formation of Superoxide Anion during Ferrous Ion-Induced Decomposition of Linoleic Acid Hydroperoxide under Aerobic Conditions. AU - Kambayashi, Yasuhiro. AU - Tero-Kubota, Shozo. AU - Yamamoto, Yorihiro. AU - Kato, Masashi. AU - Nakano, Minoru. AU - Yagi, Kunio. AU - Ogino, Keiki. PY - 2003/12. Y1 - 2003/12. N2 - We studied the mechanism of formation of oxygen radicals during ferrous ion-induced decomposition of linoleic acid hydroperoxide using the spin trapping and chemiluminescence methods. The formation of the superoxide anion (O2.-) was verified in the present study. The hydroxyl radical is also generated through Fenton type decomposition of hydrogen peroxide produced on disproportionation of O2.-. A carbon-centered radical was detected using 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) as a spin trap. Alkoxyl radical formation is essential for the conversion of linoleic acid hydroperoxide into the peroxyl radical by ferrous ion. It is likely that the ...
Dynamic Nuclear Polarization (DNP) is often achieved by the direct transfer of polarization from electrons to nuclei such as C-13, induced by microwave saturation of the wings of narrow EPR lines of radicals like trityl. In the indirect approach on the other hand, DNP is used to transfer the polarization from the electrons of radicals such as nitroxides that have broad EPR lines to nuclear spins I = H-1, followed by cross-polarization (CP) from I = H-1 to S = C-13 or other nuclei with low gyromagnetic ratios. This approach is particularly attractive for S = N-15, since direct DNP yields modest polarizations P(N-15) , 4% with build-up times that can be as long as tau DNP(N-15) , 2 h. In this paper, we show that CP from H-1 to N-15 at 1.2 K can yield P(N-15) = 25% with iota CP-DNP(N-15) = 10-15 min. After rapid dissolution and transfer to a solution-state NMR spectrometer, a polarization P(N-15) = 20% was observed at 300 K. The longitudinal relaxation times in solution can be as long as T-1(N-15) ...

Cellular signaling with nitric oxide and cyclic guanosine monophosphate.  - PubMed - NCBICellular signaling with nitric oxide and cyclic guanosine monophosphate. - PubMed - NCBI

Cellular signaling with nitric oxide and cyclic guanosine monophosphate.. Martin E1, Davis K, Bian K, Lee YC, Murad F. ... The understanding of the formation and biological actions of nitric oxide (NO) has grown extensively during the past two ... With the discoveries of the biological effects of NO and nitrovasodilators on cyclic guanosine monophosphate, with the ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10709849?dopt=Abstract

The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the...The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the...

The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the ... We investigated the involvement of nitric oxide (NO) in the phosphorylation of cyclic adenosine monophosphate-responsive ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/14622772

Enantioselective addition of cyclic enol silyl ethers to 2-alkenoyl-pyridine-N-oxides catalysed by Cu(II)-bis(oxazoline)...Enantioselective addition of cyclic enol silyl ethers to 2-alkenoyl-pyridine-N-oxides catalysed by Cu(II)-bis(oxazoline)...

Enantioselective addition of cyclic enol silyl ethers to 2-alkenoyl-pyridine-N-oxides catalysed by Cu(II)-bis(oxazoline) ... Asymmetric reactions involving (E)-3-aryl-1-(pyridin-2-yl-N-oxide)prop-2-en-1-ones and cyclic enol silyl ethers show good ...
more infohttps://www.sigmaaldrich.com/catalog/papers/22847937

Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production? |...Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production? |...

Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production?. ... Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production? ... Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production? ... Is Measurement of Cyclic Guanosine Monophosphate in Plasma or Urine Suitable for Assessing In Vivo Nitric Oxide Production? ...
more infohttp://circ.ahajournals.org/content/97/12/1209.full

Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy  -...Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy -...

Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy ... Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy ... Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy ... Electrochemical analysis of nanostructured iron oxides using cyclic voltammetry and scanning electrochemical microscopy. ...
more infohttps://eprints.soton.ac.uk/403546/

Phosphodiesterase type 5 (PDE5) is co-localized with key proteins of the nitric oxide/cyclic GMP signaling in the human prostatePhosphodiesterase type 5 (PDE5) is co-localized with key proteins of the nitric oxide/cyclic GMP signaling in the human prostate

... namely cyclic GMP, the neuronal nitric oxide synthase (nNOS), and cyclic GMP-binding protein kinases type I (cGKI alpha, cGKI ... Hence, the significance of the nitric oxide (NO)/cyclic GMP signaling in the control of the human prostate requires further ... Phosphodiesterase type 5 (PDE5) is co-localized with key proteins of the nitric oxide/cyclic GMP signaling in the human ... less thanbrgreater than less thanbrgreater thanThe findings give hints that the cyclic GMP- and cyclic AMP-dependent signal ...
more infohttp://www.diva-portal.org/smash/record.jsf?pid=diva2:635755

PRIME PubMed | Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic...PRIME PubMed | Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic...

Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathwa were found in PRIME PubMed. ... In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic ... In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic ... TY - JOUR T1 - Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic ...
more infohttps://www.unboundmedicine.com/medline/citation/18789921/Antidepressant_like_effect_of_folic_acid:_Involvement_of_NMDA_receptors_and_L_arginine_nitric_oxide_cyclic_guanosine_monophosphate_pathway_

The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells | Journal of...The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells | Journal of...

nitric oxide. cGMP. cyclic guanylate monophosphate. db cCMP. dibutyryl cyclic cytidine monophosphate. SNAP. s-nitrosos-N-acetyl ... The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells. B. L. ... The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells. B. L. ... The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells. B. L. ...
more infohttp://jpet.aspetjournals.org/content/284/3/929

Nitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process | Plant PhysiologyNitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process | Plant Physiology

Durner J, Wendehenne D, Klessig D (1998) Defense gene induction in tobacco by nitric oxide, cyclic GMP and cyclic ADP-ribose. ... Nitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process. Gabriela Carolina ... Nitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process ... Nitric Oxide and Cyclic GMP Are Messengers in the Indole Acetic Acid-Induced Adventitious Rooting Process ...
more infohttp://www.plantphysiol.org/content/132/3/1241

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent...AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent...

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent ... AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent ... AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent ... AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent ...
more infohttps://mcb.asm.org/content/36/24/3086

Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: Relation to...Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: Relation to...

... and cyclic adenosine monophosphate (cAMP) phosphodiesterases (PDEs) in relation to nitric oxide synthase isoforms and ... Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: Relation to ... Nitric oxide and VIP, mediating biologic signals through cGMP and cAMP, have been assumed to be involved in the control of ... OBJECTIVES: To evaluate the distribution of cyclic guanosine monophosphate (cGMP) ...
more infohttp://liu.diva-portal.org/smash/record.jsf?pid=diva2:353349

Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function:...Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function:...

Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: ... Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: ... Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: ... Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: ...
more infohttp://molpharm.aspetjournals.org/content/49/6/1058

Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of...Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of...

Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of ... Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of ... Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of ... Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Evidence for an effector role of ...
more infohttp://www.biochemj.org/content/287/1/229

HKU Scholars Hub: Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron...HKU Scholars Hub: Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron...

Article: Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide ... Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide Nanoparticles ... Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide Nanoparticles ... and post-monocrystalline iron oxide nanoparticle (MION) gradient echo (GE) cine images. Cyclic changes of MBV in normal mice ...
more infohttp://hub.hku.hk/handle/10722/155236

Receptor-controlled phosphorylation of alpha 1 soluble guanylyl cyclase enhances nitric oxide-dependent cyclic guanosine 5...Receptor-controlled phosphorylation of alpha 1 soluble guanylyl cyclase enhances nitric oxide-dependent cyclic guanosine 5'...

... by increasing nitric oxide (NO) synthase activity in a calcium- and kinase-dependent manner. Here we show that normal and GH(3 ... Receptor-controlled phosphorylation of alpha 1 soluble guanylyl cyclase enhances nitric oxide-dependent cyclic guanosine 5- ... The Role of Cyclic Nucleotides in Pituitary Lactotroph Functions. *Marek Kucka, Ivana Bjelobaba, Melanija Tomić, Stanko S. ... Receptor-controlled phosphorylation of alpha 1 soluble guanylyl cyclase enhances nitric oxide-dependent cyclic guanosine 5- ...
more infohttps://www.semanticscholar.org/paper/Receptor-controlled-phosphorylation-of-alpha-1-in-Kostic-Andric/fee2bc85ac857d0e72db62841336038c2206abab

Role of nitric oxide/cyclic GMP and cyclic AMP in beta3 adrenoceptor-chronotropic response. - Semantic ScholarRole of nitric oxide/cyclic GMP and cyclic AMP in beta3 adrenoceptor-chronotropic response. - Semantic Scholar

This countervailing negative chronotropic nitric oxide-cyclic GMP (NO-cGMP) significantly correlated with the increase on NOS ... On the other hand, the ZD 7114 activity on frequency was enhanced by the inhibition of nitric oxide synthase (NOS) and soluble ... 7114 and ICI 215001 stimulated in a dose-dependent manner the contraction frequency that significantly correlated with cyclic ... Role of nitric oxide/cyclic GMP and cyclic AMP in beta3 adrenoceptor-chronotropic response.. @article{SterinBorda2006RoleON, ...
more infohttps://www.semanticscholar.org/paper/Role-of-nitric-oxide%2Fcyclic-GMP-and-cyclic-AMP-in-Sterin-Borda-Bernabeo/d1623b503f3076b2e41a4ba3f0943a1aec641b19

Faculty Collaboration Database - Mesh term Cyclic N-OxidesFaculty Collaboration Database - Mesh term Cyclic N-Oxides

Mesh term Cyclic N-Oxides. Browse to parent terms:. Heterocyclic Oxides. Description. Heterocyclic compounds in which an oxygen ... 4-Hydroxyaminoquinoline-1-oxide. 4-Nitroquinoline-1-oxide. Triacetoneamine-N-Oxyl. Search for this term in our Faculty Database ... is attached to a cyclic nitrogen.. Browse to child terms:. ...
more infohttps://fcd.mcw.edu/?module=search&func=showTerm&id=68003497

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation...Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation...

This has profound consequences for the regulation of local cyclic nucleotide and hence cardiac β-adrenergic signaling. ... We therefore tested the hypothesis that PMCA4 has a key structural role in tethering neuronal nitric-oxide synthase to a highly ... Surprisingly, in PMCA4(-/-), over 36% of membrane-associated neuronal nitric-oxide synthase (nNOS) protein and activity was ... is a regulator of neuronal nitric-oxide synthase, the physiological consequence of this regulation is unclear. ...
more infohttps://www.dpag.ox.ac.uk/publications/237823

Synthesis of cadmium oxide and carbon nanotube based nanocomposites and their use as a sensing interface for xanthine detection...Synthesis of cadmium oxide and carbon nanotube based nanocomposites and their use as a sensing interface for xanthine detection...

Cyclic voltammetric measurement and testing of xanthine biosensor. The cyclic voltammogram (CV) of XOD/CdO-NPs/c-MWCNT/Au ... 7 Cyclic voltammograms of: (a) bare Au electrode, (b) CdO-NPs/c-MWCNT/Au electrode, (c) XOD/CdO-NPs/c-MWCNT/Au electrode in pH ... The cyclic voltammogram of the CdO-NPs/c-MWCNT/Au electrode identified an oxidation peak at −290 mV (curve b). MWCNT is used as ... Cyclic voltammetry response of XOD/CdO-NPs/c-MWCNT modified Au electrode. A method is described for the construction of an ...
more infohttps://pubs.rsc.org/en/content/articlehtml/2015/ra/c5ra00050e

Nitric oxide in control of luminescence from hatchetfish (Argyropelecus hemigymnus) photophores | Journal of Experimental...Nitric oxide in control of luminescence from hatchetfish (Argyropelecus hemigymnus) photophores | Journal of Experimental...

dibutyrylguanosine 5′,5′-cyclic monophosphate. cGMP. cyclic guanosine monophosphate. Δ. TLmaxTLmax (control preparations)-TLmax ... inducible nitric oxide synthase. IR. immunoreactivity. Lmax. maximal light emission NO nitric oxide NOS nitric oxide synthase ... endothelial nitric oxide synthase. eNOS-LI IR. endothelial nitric oxide synthase-like immunoreactivity. iNOS. ... NOS-LI IR nitric oxide synthase like immunoreactivity nNOS neuronal nitric oxide synthase nNOS-LI IR neuronal nitric oxide ...
more infohttps://jeb.biologists.org/content/208/15/2951?ijkey=895bc9606d561a00c3f7b26e67a7e1a1168a94ee&keytype2=tf_ipsecsha

Nitric oxide in control of luminescence from hatchetfish (Argyropelecus hemigymnus) photophores | Journal of Experimental...Nitric oxide in control of luminescence from hatchetfish (Argyropelecus hemigymnus) photophores | Journal of Experimental...

dibutyrylguanosine 5′,5′-cyclic monophosphate. cGMP. cyclic guanosine monophosphate. Δ. TLmaxTLmax (control preparations)-TLmax ... inducible nitric oxide synthase. IR. immunoreactivity. Lmax. maximal light emission NO nitric oxide NOS nitric oxide synthase ... endothelial nitric oxide synthase. eNOS-LI IR. endothelial nitric oxide synthase-like immunoreactivity. iNOS. ... NOS-LI IR nitric oxide synthase like immunoreactivity nNOS neuronal nitric oxide synthase nNOS-LI IR neuronal nitric oxide ...
more infohttps://jeb.biologists.org/content/208/15/2951?ijkey=30abcae892fc65c3bd6c9fa207e1f1f3769da8d4&keytype2=tf_ipsecsha

Holdings: The Neuroanatomy of Nitric Oxide-Cyclic GMP...Holdings: The Neuroanatomy of Nitric Oxide-Cyclic GMP...

The Neuroanatomy of Nitric Oxide-Cyclic GMP Signaling in the Locust: Functional Implications for Sensory Systems Recent studies ... have investigated the source and target neurons for the diffusible neuronal messenger molecule nitric oxide (NO) in the nervous ...
more infohttp://library.mpifg.de/Record/JST007806213

The Nature of Surface Oxides on Corrosion-Resistant Nickel Alloy Covered by Alkaline WaterThe Nature of Surface Oxides on Corrosion-Resistant Nickel Alloy Covered by Alkaline Water

Cyclic Voltammetry. The cyclic voltammogram presented in Fig. ​Fig.22 shows the surface processes occurring on alloy C22 in ... For the oxide film formed at −0.1 V, the content of Cr-oxide is higher in the outer layer of the film, which was ~51% formed in ... However, for the oxide films formed at −0.5 and 0.26 V, this dual-layered structure was not observed. And the Ni-oxides were ... The depth profile for the oxide films on C22 by AES (not shown here) showed more Cr-oxide was formed in 0.1 M KOH, which is ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC2893917/

Dexamethasone Up-Regulates a Constitutive Nitric Oxide Synthase in Cerebellar Astrocytes but Not in Granule Cells in Culture -...Dexamethasone Up-Regulates a Constitutive Nitric Oxide Synthase in Cerebellar Astrocytes but Not in Granule Cells in Culture -...

Treatment of rat cerebellar astrocyte-enriched primary cultures with dexamethasone enhances the nitric oxide-dependent cyclic ... Stimulation of cyclic GMP formation by the calcium ionophore A23187 is similarly enhanced. In contrast, cyclic GMP accumulation ... A. Law, J. ODonnell, S. Gauthier, R. Quirion, Neuronal and inducible nitric oxide synthase expressions and activities in the ... Marco Colasanti, Tiziana Persichini, Nitric oxide: an inhibitor of NF-κB/Rel system in glial cells, Brain Research Bulletin, ...
more infohttp://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.1995.64010447.x/full

Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development | Molecular Neurodegeneration |...Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development | Molecular Neurodegeneration |...

The list of effects of nitric oxide that are independent of cyclic GMP formation is also growing at a rapid rate. For example, ... Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development. ... There have been and will continue to be many opportunities from nitric oxide and cyclic GMP march to develop novel and ... Recognition of additional molecular targets in the areas of nitric oxide and cyclic GMP research will continue to promote drug ...
more infohttps://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-7-S1-L1
  • It is also useful as a metallurgical reducing agent , because at high temperatures it reduces many metal oxides to the elemental metal. (britannica.com)
  • Transition metal oxides have been extensively investigated these years. (nature.com)
  • Described herein are inks and coating compositions comprising semiconductor metal oxides and composites thereof, which are natural environmentally sustainable materials that may be recycled and/or reused indefinitely. (sumobrain.com)
  • Semiconductor metal oxides offer an alternative to relatively more toxic, non-sustainable, photo and heat-degrading, migrating traditional photoinitiator agents used in actinic radiation curable compositions. (sumobrain.com)
  • The semiconductor metal oxides and composites thereof absorb visible or UV-light as photocatalysts and/or semiconductors, or absorb electron beam radiation, forming radicals for radical events such as polymerization reactions and color enhancement events. (sumobrain.com)
  • 1,2 Metal oxides and nitrides, such as TiO 2 , Fe 2 O 3 , WO 3 , BiVO 4 , and Ta 3 N 5 , have been extensively studied as promising photoanodes for water oxidation owing to their low cost and good chemical stability in appropriate electrolytes. (rsc.org)
  • The metal oxides and metals on Si can not only improve the stability of Si photoanodes, but also serve as the oxygen evolution catalyst. (rsc.org)
  • However, in many cases, the performance of a photoanode including photovoltage, photocurrent and stability, is sensitive to the thickness of the metal oxides or metals. (rsc.org)
  • Electrochemical impedance spectroscopic (EIS) and Mott-Schottky (M-S) methods were used to determine the density and mobility of charge carriers in the passive oxide layer to understand the nature of the surface oxides and how these affect the corrosion resistance of C22 nickel alloy covered by alkaline water. (pubmedcentralcanada.ca)
  • Electrochemical Impedance Spectroscopy (EIS) study of a fully-modeled 3D solid oxide fuel cell (SOFC). (comsol.com)
  • The administration of 7-nitroindazole (25 and 50 mg/kg, i.p., a specific neuronal nitric oxide synthase (nNOS) inhibitor) or methylene blue (20 mg/kg, i.p., direct inhibitor of both nitric oxide synthase and soluble guanylate cyclase) in combination with a sub-effective dose of folic acid (1 nmol/site, i.c.v.) reduced the immobility time in the FST as compared with either drug alone. (unboundmedicine.com)
  • METHODS: Immunohistochemical techniques were applied to sectioned specimens of the human vaginal wall to evaluate the presence of the PDE isoenzymes 3, 4, 5, and 10 in relation to neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and VIP. (diva-portal.org)
  • Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. (ox.ac.uk)
  • Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent ATPase 4 (PMCA4) is a regulator of neuronal nitric-oxide synthase, the physiological consequence of this regulation is unclear. (ox.ac.uk)
  • We therefore tested the hypothesis that PMCA4 has a key structural role in tethering neuronal nitric-oxide synthase to a highly compartmentalized domain in the cardiac cell membrane. (ox.ac.uk)
  • The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intra. (nih.gov)
  • less thanbrgreater than less thanbrgreater thanIn the smooth muscle portion of the transition zone, immunosignals specific for the PDE5 were found co-localized with cyclic GMP, cGKI alpha, and cGKI, as well as with the cyclic cAMP-binding protein kinase A. Smooth muscle bundles were seen innervated by slender varicose nerves characterized by the expression of nNOS. (diva-portal.org)
  • We show here that K-Ras is a substrate for cyclic GMP-dependent protein kinases (PKGs). (asm.org)
  • K-Ras phosphorylation by PKG2 is triggered by activation of AMP-activated protein kinase (AMPK) and requires endothelial nitric oxide synthase and soluble guanylyl cyclase. (asm.org)
  • Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: inhibitory role mediated by cyclic GMP-dependent protein kinase. (aspetjournals.org)
  • Cyclic GMP, in turn, can activate cyclic GMP-dependent protein kinase (PKG) and can cause smooth muscles and blood vessels to relax, decrease platelet aggregation, alter neuron function, etc. (biomedcentral.com)
  • Some of these reactions result in the oxidation of nitric oxide to nitrite and nitrate to terminate the effect, while other reactions can lead to altered protein structure function and/or catalytic capacity. (biomedcentral.com)
  • The authors review what is known about the deleterious effects of sickling on the genitourinary tract and how the role of cyclic nucleotides signaling and protein kinases may help understand the pathophysiology underlying these manifestations and develop novel therapies in the setting of urogenital disorders in sickle cell disease. (hindawi.com)
  • This paper focuses on how previous, sometimes poorly explained, clinical observations of urogenital disorders in patients with SCD relate to more recent discoveries on the role of cyclic nucleotides and protein kinases in the pathophysiology of sickle vaso-occlusion. (hindawi.com)
  • The effects of cyclic nucleotides to suppress PKG-Iα promoter activity were attenuated by a specific cAMP-dependent protein kinase (PKA) inhibitor. (elsevier.com)
  • and also interacts with several important synaptic proteins, including synaptic GTPase-activating protein, neuroligins, or nitric oxide (NO) synthase (NOS), which might mediate trans-synaptic signaling ( Kim and Sheng, 2004 ) for synapse formation or stabilization. (rupress.org)
  • Enantioselective addition of cyclic enol silyl ethers to 2-alkenoyl-pyridine-N-oxides catalysed by Cu(II)-bis(oxazoline) complexes. (sigmaaldrich.com)
  • Asymmetric reactions involving (E)-3-aryl-1-(pyridin-2-yl-N-oxide)prop-2-en-1-ones and cyclic enol silyl ethers show good yields and excellent enantioselectivities (up to 99.9 % ee) when catalysed by bis(oxazoline)-Cu(II) complexes. (sigmaaldrich.com)
  • Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide. (biochemj.org)
  • Inhibition of islet glucose oxidation appears to be mediated by nitric oxide since both NMMA and cycloheximide prevent IL-1 beta-induced inhibition of glucose oxidation. (biochemj.org)
  • The inhibition of nitric oxide production, as well as the blockade of N-methyl-D-aspartate receptors, has been reported to prevent the induction of hippocampal long-term potentiation and learning and memory formation in vivo, although the effects of inhibitors of nitric oxide synthase are still controversial. (fujita-hu.ac.jp)
  • Hamet P, Pang SC, Tremblay J. Atrial natriuretic factor-induced egression of cyclic guanosine monophosphate in cultured vascular smooth muscle and endothelial cells. (ahajournals.org)
  • Nitric oxide (NO) is a potent endogenous vasodilator and has shown to inhibit key processes of atherosclerosis like monocyte adhesion, platelet aggregation, and vascular smooth muscle cell proliferation. (clinicaltrials.gov)
  • Cyclic nucleotides have been thought of as second messengers in various tissues, including platelets and vascular smooth muscle cells. (ahajournals.org)
  • A Biomimetic Route to Lignin Model Compounds via Silver (I) Oxide Oxidation. (degruyter.com)
  • 6 h) and concentration-dependent manner (half-maximal effect at 1 n M ). Stimulation of cyclic GMP formation by the calcium ionophore A23187 is similarly enhanced. (wiley.com)
  • For example, calcium carbonate (CaCO 3 ) produces carbon dioxide and calcium oxide (CaO). (britannica.com)
  • A Spermatid Factor Inhibits Cyclic AMP and Calcium Signaling in Sertoli but Not Leydig Cells. (elsevier.com)
  • The inhibitory effects of both N(G)- nitro-L-arginine methyl ester and dizocilpine on their behavior were completely reversed by 8-bromo-cyclic GMP. (fujita-hu.ac.jp)
  • N(G)-Nitro-L-arginine methyl ester and 7-nitro indazole reduced cyclic GMP levels in the cerebral cortex/hippocampus and cerebellum, and the suppressive effect of N(G)- nitro-L-arginine methyl ester on cyclic GMP levels in the cerebral cortex/hippocampus was reversed by co-treatment with L-arginine. (fujita-hu.ac.jp)
  • Cyclic AMP levels in the brain were not affected by treatment with either dizocilpine, N(G)-nitro-L-arginine methyl ester, or 7-nitro indazole. (fujita-hu.ac.jp)
  • Xanthine oxidase (XOD) extracted from bovine milk was immobilized covalently via N -ethyl- N ′-(3-dimethylaminopropyl)carbodiimide (EDC) and N -hydroxy succinimide (NHS) chemistry onto cadmium oxide nanoparticles (CdO)/carboxylated multiwalled carbon nanotube (c-MWCNT) composite film electrodeposited on the surface of an Au electrode. (rsc.org)
  • Thus, it can be suggested that a stable proportion of Ni(II)/Ni(III) oxides-hydroxides was obtained on the electrode surfaces. (scirp.org)
  • After the first announcement of commercialization of tin dioxide (SnO 2 ) as a negative electrode of lithium-ion batteries, this transition metal oxide anode has received much concern. (pubmedcentralcanada.ca)
  • Some of the methods to regulate either nitric oxide formation metabolism, or function have been in clinical use for more than a century, as with the use of organic nitrates and nitroglycerin in angina pectoris that was initiated in the 1870s. (biomedcentral.com)
  • Current and future research will undoubtedly expand the clinician's therapeutic armamentarium to manage a number of important diseases by perturbing nitric oxide formation and metabolism. (biomedcentral.com)
  • Iron-nitrosyl complex-formation by islets confirms that IL-1 beta induces the generation of nitric oxide by islets, and provides evidence indicating that nitric oxide mediates destruction of iron-sulphur clusters of iron-containing enzymes. (biochemj.org)
  • These results also suggest that nitric oxide mediates IL-1 beta-induced inhibitory effects on the pancreatic beta-cell by functioning as an effector molecule responsible for the destruction of iron-sulphur centres of iron-containing proteins, resulting in an impairment of mitochondrial function. (biochemj.org)
  • Acid-catalyzed positive photoresist compositions which are imageable with 193 nm radiation and are developable to form photoresist structures of high resolution and high etch resistance are enabled by the use of a combination of cyclic olefin polymer, photosensitive acid generator and a hydrophobic non-steroidal. (google.com.au)
  • The cyclic olefin polymers preferably contain i) cyclic olefin units having polar functional moieties, ii) cyclic olefin units having acid labile moieties that inhibit solubility in aqueous alkaline solutions. (google.com.au)
  • Cyclic tetramers of some olefin oxides. (alfa.com)
  • Carbon forms two well-known oxides, carbon monoxide , CO, and carbon dioxide , CO 2 . (britannica.com)
  • For example, copper (II) oxide, CuO, and iron (III) oxide, Fe 2 O 3 , are both reduced to the metal by carbon monoxide. (britannica.com)
  • Nitric oxide can function as an intracellular messenger, an antacoid, a paracrine substance, a neurotransmitter, or as a hormone that can be carried to distant sites for effects. (biomedcentral.com)
  • The Nitric Oxide-Cyclic GMP Signal Transduction System for Intracellular and Intercellular Communication. (elsevier.com)
  • The key component is the complexing agent, which comprises a C 3 -C 5 aliphatic alcohol a cyclic, bidentate compound selected from lactams and lactones. (google.es)
  • We report a deposition of the tin oxide/hydroxide nanostructured layer by the potentiodynamic method from acidic nitrate solutions directly over the substrate, equipped with multiple strip electrodes which is employed as a gas-analytical multisensor array chip. (mdpi.com)
  • Special potential scan programs were designed for cyclic voltammetric development of β-NiOOH or γ-NiOOH/ β-NiOOH mixtures on the surface of nickel or nickel-chromium (80:20) alloy electrodes in NaOH 0.10 M. The programs consisted on changing the anodic or cathodic switching limit to facilitate the chemical reactions taking place either between Ni(II) hydroxides or between Ni(III) oxides-hydroxides. (scirp.org)
  • A nickel alloy with high chrome and molybdenum content was found to form a highly resistive and passive oxide layer. (pubmedcentralcanada.ca)
  • The donor density and mobility of ions in the oxide layer has been determined as a function of the electrical potential when alkaline water layers are on the alloy surface in order to account for the relative inertness of the nickel alloy in corrosive environments. (pubmedcentralcanada.ca)
  • The stability is often attributed to the inertness of the oxides that form on the nickel alloys. (pubmedcentralcanada.ca)
  • Examples of systems that may be studied include lead-acid batteries, lithium-ion batteries, nickel metal-hydride batteries, solid oxide fuel cells (SOFCs), direct-methanol fuel cells (DMFCs), and proton exchange membrane fuel cells (PEMFCs). (comsol.com)
  • The methods include reacting a polyalkylene oxide such as polyethylene glycol with a t-butyl haloacetate in the presence of a base followed by treatment with an acid such as trifluoroacetic acid. (google.com)
  • 2. The method of claim 1, wherein said polyalkylene oxide is polyethylene glycol. (google.com)
  • Photosynthetic electron flux allocation, stomatal conductance, and the activities of key enzymes involved in photosynthesis were investigated in Rumex K-1 leaves to better understand the role of nitric oxide (NO) in photoprotection under osmotic stress caused by polyethylene glycol. (springer.com)
  • Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biological processes. (biomedcentral.com)
  • Cyclic GMP has been proposed to regulate axonal development, but the molecular and cellular mechanisms underlying the formation of axon branches are not well understood. (jneurosci.org)
  • Recent studies have investigated the source and target neurons for the diffusible neuronal messenger molecule nitric oxide (NO) in the nervous system of the locust. (mpifg.de)
  • Fe{sub 2.25}W{sub 0.75}O{sub 4}/reduced graphene oxide (RGO) composites were prepared for application of novel bifunctional photocatalyst via simple one-pot hydrothermal method, employing graphene oxide (GO), Na{sub 2}WO{sub 4}, FeSO{sub 4} and sodium dodecyl benzene sulfonate (SDBS) as the precursors. (osti.gov)