Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Time period from 1901 through 2000 of the common era.
The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.
Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.
Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.
The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.
The stage in the first meiotic prophase, following ZYGOTENE STAGE, when CROSSING OVER between homologous CHROMOSOMES begins.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.
A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
The field of biology which deals with the process of the growth and differentiation of an organism.
A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
A state of extreme acute, intense anxiety and unreasoning fear accompanied by disorganization of personality function.
Obsessive, persistent, intense fear of open places.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Persistent and disabling ANXIETY.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.
The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.
An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.
Inorganic salts of phosphoric acid.

CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes. (1/246)

Previously, we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain Fra-1, Fra-2, Jun B, Jun D and c-Jun proteins that bind to the AP-1 DNA binding sequence. Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells. Here, we have detected the CREB family proteins CREB and CREMalpha as additional participants in the AP-1 DNA binding complex in differentiating keratinocytes. AP-1 and CRE DNA binding activity correlated with the induction of CREB, CREMalpha and ATF-1 and CREB phosphorylation at ser133 (ser133 phospho-CREB) in the transition from basal to differentiating keratinocytes, but the activity of a CRE reporter remained unchanged. In contrast, the CRE reporter was activated in the presence of the dominant-negative (DN) CREB mutants, KCREB and A-CREB, proteins that dimerize with CREB family members and block their ability to bind to DNA. The increase in CRE reporter activity in the presence of these mutants suggests that CRE-mediated transcriptional activity is suppressed in keratinocytes through protein-protein interactions involving a factor that dimerizes with the CREB leucine zipper. In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct, transcriptional activity was also increased indicating that a CREB family member binds AP-1 sites and represses AP-1 transcriptional activity as well. Exogenous expression of the transcriptional repressor CREMalpha down-regulated both CRE and AP-1 reporters in keratinocytes suggesting that this factor may contribute to the suppression of AP-1 transcriptional activity observed in differentiating keratinocytes.  (+info)

Regulation of cAMP responsive element binding modulator isoforms in cultured rat ovarian granulosa cells. (2/246)

A pituitary glycoprotein hormone FSH stimulates ovarian granulosa cells to induce ovarian follicular development. In this study we identified rat ovarian genes that were rapidly induced by FSH in the cultured rat granulosa cells by means of subtraction cloning. Complementary DNA clones encoding cAMP responsive element binding modulator (CREM) were identified as one of the FSH inducible genes. Northern blotting and reverse transcription and polymerase chain reaction (RT-PCR) analyses revealed that only the repressor type of CREM gene products, ICER (inducible cAMP early repressor) isoforms, were induced by FSH treatment in cultured rat granulosa cells. The induction of ICER by FSH was mimicked by reagents known to increase intracellular cAMP levels, indicating that the induction is through cAMP and protein kinase A signal transduction system. Induction of ICER was also confirmed as the protein levels. Electrophoretic mobility shift assay of granulosa cell extracts with a radiolabeled double stranded oligonucleotide corresponding to somatostatin cAMP responsive element also revealed that only the ICER proteins were induced by FSH treatment, whereas levels of CREM proteins were nearly constant regardless of the FSH treatment. Our present study demonstrates that FSH-induced and cAMP-mediated induction and attenuation of transcriptional responses by CREM gene products may be a key mechanistic component for the granulosa cell differentiation and proliferation.  (+info)

Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. (3/246)

Neurotransmitter-driven activation of transcription factors is important for control of neuronal and neuroendocrine functions. We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). pCREB accumulates endogenously at the beginning of the dark period and declines during the second half of the night. Concomitant with this decline, the amount of ICER rises. The changing ratio between pCREB and ICER shapes the in vivo dynamics in mRNA and, thus, protein levels of arylalkylamine-N-acetyltransferase, the rate-limiting enzyme of melatonin synthesis. Consequently, a silenced ICER expression in pinealocytes leads to a disinhibited arylalkylamine-N-acetyltransferase transcription and a primarily enhanced melatonin synthesis.  (+info)

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (4/246)

Ubiquitin-mediated proteolysis controls diverse physiological processes in eukaryotes. However, few in vivo targets of the mammalian Cdc34 and Rad6 ubiquitin-conjugating enzymes are known. A yeast-based genetic assay to identify proteins that interact with human Cdc34 resulted in three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog. Transfection assays with mammalian cells demonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIgamma and hATF5. This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription. Consistent with these results, the endogenous ICER protein is elevated in cells which are null for murine Rad6B (mHR6B-/-) or transfected with dominant negative and antisense constructs of human CDC34. Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development. Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regulated manner, with distinctly different patterns for Cdc34 and the Cullin proteins in germ cells. The Cdc34 and Rad6B proteins are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modifications occur. Thus, the stability of specific mammalian transcription factors is the result of complex targeting by multiple ubiquitin-conjugating enzymes and may have an impact on cAMP-inducible gene regulation during both meiotic and mitotic cell cycles.  (+info)

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (5/246)

The p38/stress-activated protein kinase2 (p38/SAPK2) is activated by cellular stress and proinflammatory cytokines. Several transcription factors have been reported to be regulated by p38/SAPK2, and this kinase is involved in the control of expression of various genes. In human Jurkat T-cells, induction of the early growth response gene-1 (egr-1) by anisomycin is completely inhibited by SB203580, a specific inhibitor of p38/SAPK2a and -b. Northern blot and reporter gene experiments indicate that this block is at the level of mRNA biosynthesis. Using mutants of the egr-1 promoter, we demonstrate that a distal cAMP-responsive element (CRE; nucleotides -134 to -126) is necessary to control egr-1 induction by p38/SAPK2. Pull-down assays indicate that phospho-CRE binding protein (CREB) and phospho-activating transcription factor-1 (ATF1) bind to this element in a p38/SAPK2-dependent manner. In response to anisomycin, two known CREB kinases downstream to p38/SAPK2, MAPKAP kinase 2 (MK2) and mitogen- and stress-activated kinase 1 (MSK1), show increased activity. However, in MK2 -/- fibroblasts derived from mice carrying a disruption of the MK2 gene, the phosphorylation of CREB and ATF1 and the expression of egr-1 reach levels comparable with wild type cells. This finding excludes MK2 as an involved enzyme. We conclude that egr-1 induction by anisomycin is mediated by p38/SAPK2 and probably by MSK1. Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene.  (+info)

The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. (6/246)

We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs). We isolated two novel CREM isoforms (CREMDeltaQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six known isoforms (CREMtaualpha, CREMalpha, inducible cyclic AMP early repressor (ICER) I, ICER Igamma, CREM-17X, and CREM-17) from rat pancreatic islets and the RINm5F pancreatic beta-cell line. CREM isoforms functioned as efficient transcriptional activators or repressors to modulate insulin promoter activity by binding to all of the insulin CREs. The binding activity of repressors is higher than that of activators and suppressed not only basal activity but also activator-induced activities. Furthermore, CREM activator interacted directly with the transcription factor IID components hTAF(II)130 and TATA box-binding protein (TBP). These results suggest that the activation of the insulin gene transcription by CREM activator is mediated by not only direct binding to the CREs but also by recruiting transcription factor IID to the insulin promoter via its interaction with hTAF(II)130 and TBP. On the other hand, the CREM repressor ICER competitively interrupts the binding of the activators to CREs and does not interact with either TBP or hTAF(II)130; therefore, it might fail to stabilize the basal transcriptional machinery and repress transactivation.  (+info)

A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids. (7/246)

During murine spermatogenesis, beginning in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site. We had shown previously that a 796-bp genomic fragment that flanks the germ cell start site and contains two putative CRE (cyclic AMP-responsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase reporter gene in late pachytene spermatocytes and round spermatids of transgenic mice (N. L. Shaper, A. Harduin-Lepers, and J. H. Shaper, J. Biol. Chem. 269:25165-25171, 1994). We now report that in vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously undescribed 14-bp regulatory element (5'-GCCGGTTTCCTAGA-3') that is distinct from the two CRE-like sequences. This cis element is located 16 bp upstream of the germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (transcriptional activator in late pachytene spermatocytes and round spermatids 1). The presence of the Ets signature binding motif 5'-GGAA-3' on the bottom strand of the TASS-1 sequence (underlined sequence) suggests that TASS-1 is a novel member of the Ets family of transcription factors. Additional transgenic analyses established that an 87-bp genomic fragment containing the TASS-1 regulatory element was sufficient for correct germ cell-specific expression of the beta-galactosidase reporter gene. Furthermore, when the TASS-1 motif was mutated by transversion, within the context of the original 796-bp fragment, transgene expression was reduced 12- to 35-fold in vivo.  (+info)

Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. (8/246)

Rhythmic activity of arylalkylamine N-acetyltransferase (AANAT) determines melatonin synthesis in rat pineal gland. The transcriptional regulation of AANAT involves the activating and inhibiting transcription factors of the cyclic AMP (cAMP)-signaling pathway, cAMP response element-binding protein and inducible cAMP early repressor (ICER), respectively. Activation of this pathway is centered around norepinephrine, stimulating beta(1)-adrenergic receptors, but various other transmitters can modulate melatonin biosynthesis. To compare the transcriptional impact of norepinephrine with that of other neurotransmitters on melatonin synthesis, we determined ICER protein levels in pinealocytes and, in parallel, hormone secretion. The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production. Importantly, ICER protein induction required lower ligand concentrations than the induction of melatonin biosynthesis. Although neuropeptide Y, glutamate, and vasopressin altered norepinephrine-stimulated hormone production without affecting ICER levels, the activation of voltage-gated cation channels increased ICER without affecting hormone synthesis. Sensitivity and versatility of ICER induction in pinealocytes make these neuroendocrine cells a valuable model system in which to study molecular interactions determining a regulated gene expression.  (+info)

Project Summary/Abstract Even though Inducible cAMP Early Repressor (ICER) has the functional characteristics of a tumorsuppressor, there is no genetic evidence to demonstrate that ICER is a bona fide tumor suppressor geneproduct. Thus, altered post-translational events might be the cause of the observed abnormalities of ICERprotein expression in cancer cells. On this basis it is hypothesized that in cancer cells, ICER isderegulated by ubiquitination resulting in constitutive proteasomal degradation and/or abnormalsubcellular localization. Finding alternatives to rescue endogenous ICER nuclear expression in malignantcells could lead to the development of novel cancer treatment modalities. Through this project, we will studythe mechanisms and physiological consequences of ICER ubiquitination and subcellular localization. We willuse melanoma as a paradigm for the study. This study will focus on two specific aims.Aim 1. Determine the functional and physiological consequences of ICER ubiquitination ...
3.0.CO;2-B. ISSN 1040-452X. PMID 10824972. Sassone-Corsi, P. (1998-08-01). CREM: a master-switch governing male germ cells differentiation and apoptosis. Seminars in Cell & Developmental Biology. 9 (4): 475-482. doi:10.1006/scdb.1998.0200. ISSN 1084-9521. PMID 9813195. CREM (cAMP responsive element modulator). atlasgeneticsoncology.org. Retrieved 2016-10-16. Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Molecular and Cellular Biology. 20 (22): 8613-22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166 . PMID 11046156. Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 398 (6723): 165-9. doi:10.1038/18237. PMID 10086359. Domschke, K.; Kuhlenbäumer, G.; Schirmacher, A.; Lorenzi, C.; Armengol, L.; DiBella, D.; Gratacos, M.; Garritsen, H. S.; Nöthen, M. M. (2003-02-01). Human nuclear ...
TY - JOUR. T1 - Investigation of Polymorphisms in the CREM Gene in Panic Disorder. AU - Hamilton, Steven P.. AU - Slager, Susan L.. AU - Mayo, David. AU - Heiman, Gary A.. AU - Klein, Donald F.. AU - Hodge, Susan E.. AU - Fyer, Abby J.. AU - Meissman, Myrna M.. AU - Knowles, James A.. PY - 2004/4/1. Y1 - 2004/4/1. N2 - Clinical and animal studies suggest a role for pathways regulated by cyclic-AMP in anxiety. Mouse gene deletion studies, our own linkage findings on chromosome 10, and a recently published genetic association study by Domschke et al. [2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. We have employed a family-based design to investigate the role of DNA sequence variations in the gene for CREM in panic disorder. We have genotyped 613 individuals in 70 panic disorder pedigrees, as well as 42 parent/offspring trials. Subjects were genotyped at two informative single nucleotide polymorphisms (SNPS) and three ...
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CREB activation and CREB-dependent signaling pathways are crucial for neuronal survival. The term ICER (inducible cAMP early repressor) refers to four protein isoforms that are all endogenous, inducible antagonists of CREB. It was previously shown, that all 4 ICER isoforms are induced upon pro-apoptotic treatment, and also that each of them separately evokes neuronal cell death in cortical culture transfected with these genes. The ICER proteins are believed to be strong repressors of Immediate Early Genes, which are involved in cell response to inter- and/or intra-cellular signals. Herein, we have applied the siRNA approach to silence ICER expression. Because ICERs are members of CREM family of proteins, sharing with them the gene sequence, only the small unique region for ICER was selected to design ICER-directed, specifi c siRNA. Indeed, we obtained functional siRNA capable of blocking ICERs but not affecting CREM proteins. With this tool, we have investigated if the ICERs silencing protects ...
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c-Jun enhancement of cyclic adenosine 3,5-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA.
CREB+CREM兔多克隆抗体(ab5803)可与小鼠, 大鼠, 鸡, 人样本反应并经WB, IHC, EMSA, ChIP, ICC/IF实验严格验证,被6篇文献引用并得到2个独立的用户反馈。
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Human granulocytes are characterized by a variety of specific effector functions involved in host defense. Several widely expressed protein kinases have been implicated in the regulation of these effector functions. A polymerase chain reaction- based strategy was used to identify novel granulocyte-specific kinases.Anovel protein kinase complementary DNA with an open reading frame of 357 amino acids was identified with homology ... read more to calciumcalmodulin- dependent kinase I (CaMKI). This has been termed CaMKI-like kinase (CKLiK). Analysis of CKLiK messenger RNA (mRNA) expression in hematopoietic cells demonstrated an almost exclusive expression in human polymorphonuclear leukocytes (PMN). Up-regulation of CKLiK mRNA occurs during neutrophilic differentiation of CD341 stem cells. CKLiK kinase activity was dependent on Ca11 and calmodulin as analyzed by in vitro phosphorylation of cyclic adenosine monophosphate responsive element modulator (CREM). Furthermore, CKLiKtransfected cells treated ...
Asthma is highly prevalent, but current therapies cannot influence the chronic course of the disease. It is thus important to understand underlying early molecular events. In this study, we aimed to use microRNAs (miRNAs) - which are critical regulators of signaling cascades - to identify so far uncharacterized asthma pathogenesis pathways. Therefore, deregulation of miRNAs was assessed in whole lungs from mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI). In silico predicted target genes were confirmed in reporter assays and in house-dust-mite (HDM) induced AAI and primary human bronchial epithelial cells (NHBE) cultured at the air-liquid interface. We identified and validated the transcription factor cAMP-responsive element binding protein (Creb1) and its transcriptional co-activators (Crtc1-3) as targets of miR-17, miR-144, and miR-21. Sec14-like 3 (Sec14l3) - a putative target of Creb1 - was down-regulated in both asthma models and in NHBE cells upon IL13 treatment, while its
Alzheimers disease (AD) is a progressive neurodegenerative disease and the most common form of senile dementia. Recently, scientists have put significant effort into exploring the molecular mechanisms involved in the pathological processes leading to the disease. A vast number of studies have focused on understanding the nitric oxide (NO) signaling pathway, which culminates with the phosphorylation of the transcription factor cAMP-responsive element-binding protein (CREB) through the increase of the second messenger cyclic guanosine monophosphate (cGMP) and activation of cGMP-dependent protein kinase. This book chapter provides an overview of the progress being made in modulating the hippocampal synaptic transmissions, which are critical for learning and memory, by targeting the different components of the NO/cGMP/CREB phosphorylation signaling pathway. Furthermore, a description of recent research on this pathway through the use of phosphodiesterase inhibitors is emphasized.
Hello, everyone, and welcome to this edition of Excelsior Solutions ICER Update. Here is this weeks ICER recap: This week ICER announced the beginning of the
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Spermatogenesis is coordinated by the spatial and temporal expression of many transcriptional and posttranscriptional factors. The cyclic AMP-responsive element modulator (CREM) gene encodes both activator and repressor isoforms that act as transcription factors to regulate spermiogenesis. We found that the testis-expressed paralog of CstF-64, tauCstF-64 (gene symbol Cstf2t), is involved in a polyadenylation site choice switch of Crem mRNA and leads to an overall decrease of the Crem mRNAs that are generated from internal promoters in Cstf2t(-/-) mice. More surprisingly, loss of tauCstF-64 also leads to alternative splicing of Crem exon 4, which contains an important activation domain. Thus, testis-specific CREMtau2 isoform protein levels are reduced in Cstf2t(-/-) mice. Consequently, expression of 15 CREM-regulated genes is decreased in testes of Cstf2t(-/-) mice at 25 days postpartum. These effects might further contribute to the infertility phenotype of these animals. This demonstrates that tauCstF
In type 2 diabetes, chronic hyperglycemia is detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We inves
Results Under basal conditions, freshly isolated T cells from active lupus patients had 2.3-fold higher miR-21 levels compared to healthy T cells. Combined anti-CD3/anti-CD28-stimulation induced higher miR-21 levels in SLE T cells than in controls (mean 4.0-fold vs 1.6-fold, respectively), suggesting aberrant regulation of miR-21 expression in SLE. PD-1 mRNA and miR21 levels correlated with disease activity. There was an inverse correlation between PD-1 mRNA and miR-21 levels in SLE patients (r2=−0.93) suggesting a co-regulation. This was documented by stimulating SLE T cells with anti-CD3/anti-CD28 in the presence or not of PDL1.Ig. PD-1 cross-linking reduced miR-21 levels by 45%. Moreover, silencing of PD-1, using a specific siRNA, was associated with 4.5-fold up-regulation of miR-21. Experiments are underway to elucidate the mechanisms of transcriptional regulation of miR-21 by mediators downstream to PD-1 and to correlate PD-1 genotypes with mir-21 expression.. ...
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Washington, DC, February 1, 2017)-The National Pharmaceutical Council (NPC) commented on the Institute of Clinical and Economic Reviews (ICER) updated value assessment framework, which was released today.. We recognize that developing frameworks is challenging and appreciate that ICER has made significant changes, said NPC President Dan Leonard. We look forward to reviewing the updated framework in greater detail and understanding how these changes could work in practice.. NPC has remained engaged with ICER and offered constructive feedback to improve and evolve its framework. On initial review, ICER appears to have taken steps to improve the transparency and reproducibility of its economic models, formally included patient-centered factors into the framework, and considerably revised its approach to budget impact assessment by incorporating a range of potential product uptake rates and potential prices in its calculations. It also appears that ICER will no longer calculate a value-based ...
Sigrun R. Hofmann, Emil Carlsson, Franz Kapplusch, Ana L. Carvalho, Triantafillos Liloglou, Felix Schulze, Susanne Abraham, Sarah Northey, Susanne Russ, Anna E. A. Surace, Nobuya Yoshida, George C. Tsokos and Christian M. Hedrich ...
An ICER announcement that it will review a new drug can make drugmakers and patient groups worry. There are ways to work with ICER - and alternatives to it.
To ensure that our reports are as useful as possible to our stakeholders, we would like to get a better sense of how they are being used. You will be redirected to the report after answering these brief questions. ...
TY - JOUR. T1 - Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene. AU - Di Rocco, Giuliana. AU - Pennuto, Maria. AU - Illi, Barbara. AU - Canu, Nadia. AU - Filocamo, Gessica. AU - Trani, Eugenia. AU - Rinaldi, Anna Maria. AU - Possenti, Roberta. AU - Mandolesi, Georgia. AU - Sirinian, M. Isabella. AU - Jucker, Richard. AU - Levi, Andrea. AU - Nasi, Sergio. PY - 1997/3. Y1 - 1997/3. N2 - vgf is a neurotrophin response-specific, developmentally regulated gene that codes for a neurosecretory polypeptide. Its transcription in neuronal cells is selectively activated by the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3, which induce survival and differentiation, and not by epidermal growth factor. We studied a short region of the rat vgf promoter which is essential for its regulated expression. A cyclic AMP response element (CRE) within this region is ...
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I wanted to share my response to the ICER patient input questions. I definitely went into a lot of detail. Please do not feel you need write a book.
The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization, Co-Author, (1992) Genomics 13 (4), 974-982 ...
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CREB3L1 antibody [C3], C-term (cAMP responsive element binding protein 3-like 1) for WB. Anti-CREB3L1 pAb (GTX104818) is tested in Human samples. 100% Ab-Assurance.
TY - JOUR. T1 - Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα. AU - Ruppert, Philip M.M.. AU - Park, Jong-Gil. AU - Xu, Xu. AU - Hur, Kyu Yeon. AU - Lee, Ann-Hwee. AU - Kersten, Sander. PY - 2019/3/11. Y1 - 2019/3/11. N2 - Background: Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wild-type, PPARα−/−, CREB3L3−/− and combined PPARα/CREB3L3−/− mice were subjected to a 16-h fast or 4 days of ketogenic diet. Whole genome expression analysis was performed on liver samples. Results: Under conditions of overnight fasting, the effects of PPARα ablation and CREB3L3 ablation on plasma ...
TransAM CREB and TransAM pCREB Kits are DNA-binding ELISAs that quanify the activated transcription factors using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
To ensure that our reports are as useful as possible to our stakeholders, we would like to get a better sense of how they are being used. You will be redirected to the report after answering these brief questions. ...
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016 ...
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
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Addiction Grayken Center for Addiction at Boston Medical Center Cardiology Cardiovascular Center Whitaker Cardiovascular Institute Center for Regenerative Medicine (CReM) George J. Murphy Lab
The Center for Regenerative Medicine (CReM) at Boston Medical Center has been awarded a grant to establish a first-of-its-kind stem cell repository.
TY - JOUR. T1 - Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15. AU - Xie, Fuchun. AU - Fan, Qiuhua. AU - Li, Bingbing X.. AU - Xiao, Xiangshu. PY - 2019/1/1. Y1 - 2019/1/1. N2 - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, we designed an ester prodrug of 666-15 through a long-range O,N-acyl transfer reaction for improved aqueous solubility. Unexpectedly, we discovered a small molecule 11 (653-47) that can potentiate the CREB inhibitory activity of 666-15 although 653-47 alone does not inhibit CREB.. AB - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, ...
Expression of CREM (hCREM-2) in parathyroid gland tissue. Antibody staining with HPA001818 and CAB018352 in immunohistochemistry.
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data a; run; ods graphics on; ods select DensityPanel; proc mcmc data=a stats=none diag=none nmc=10000 outpost=gout plots=density seed=1; parms gamma_3_is2 gamma_001_sc4 igamma_12_sc001 igamma_2_is01; prior gamma_3_is2 ~ gamma(shape=3, iscale=2); prior gamma_001_sc4 ~ gamma(shape=0.01, scale=4); prior igamma_12_sc001 ~ igamma(shape=12, scale=0.01); prior igamma_2_is01 ~ igamma(shape=2, iscale=0.1); model general(0); run; ods graphics off ...
Well i just wanted to take time out and wish everyone Happy Valentines Day. I hope everyone got to have there own special day. My day included my son (hes 4) giving me a valentines card. We made breafast together, and then went out to go shopping. Got alot of good deals for him on clothers as he will be starting school this year. He picked a stuffed animal for me and he picked some Ben 10 watch and accsessories for himself. I went and got my eyes checked and picked up my comntacts, and also dropped off my form for my disabled bus pass. I hope that works out, it will help alot in the long run. Well we came home, stopped and bought some ice crem and balloons and are going to finish the nite with movies. I love my son, hes my great little valentine!!! ...
Université de Rennes 1, CREM, Marsouin. Presentation at the conference organized by the Groupe dIntérêt Scientifique: Culture-Media & Numerique, the Department of studies, forecasting, and statistics (ministry of Culture and Communication) and the Innovation & Regulation in Digital Services Chair (Ecole Polytechnique, Telecom ParisTech and Orange), in Paris, February 8th, 2011. This post is also available in: French ...
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TranspariMED criticizes STAT op-ed for not disclosing pharma funding of authors institute - similar to criticism weve made of STAT op-eds in the past. @transparify @ThinkTankWatch @icer_review https://www.healthnewsreview.org/2021/02/transparency-watchdog-criticizes-stats-non-disclosure-on-pro-pharma-op-ed/ ...
"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. doi: ...
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP- ... Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ...
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ...
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... Poo, M.M. (2001). Neurotrophins as synaptic modulators. Nat Rev Neurosci, 2, 24-32 102. Yan, Q.S., Feng, M.J., Yan, S.E. (2005 ... Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ...
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many ... The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'- ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ...
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Small-molecule positive allosteric modulators of the FSHR have been developed. Alfred G. Gilman and Martin Rodbell received the ... For a cell to respond to FSH, only a small percentage (~1%) of receptor sites need to be activated.[citation needed] Cyclic AMP ... The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. ...
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators • GnRH and gonadotropins ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. ...
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... Hepatitis A 3C protease cleaves NEMO at the Q304 residue; NEMO is a NF-κB essential modulator responsible for activation of ... interferon (IFN) antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating ...
Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic ... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW (Feb 2009). "Positive allosteric modulators of the metabotropic ... Beqollari D, Kammermeier PJ (Jul 2008). "The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b] ...
... induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a ... "Structural features of subtype-selective EP receptor modulators". Drug Discovery Today. 22 (1): 57-71. doi:10.1016/j.drudis. ... EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro- ... A 2021 study found that inhibition of myeloid cell EP2 signalling can reverse or prevent an inflammation element of brain- ...
3). In the nucleus the dimer interacts with progesterone hormone response element in the DNA causing upregulation or ... and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor". Molecular and Cellular Biology. ... Phytoprogestogen Selective androgen receptor modulator Selective estrogen receptor modulator Selective glucocorticoid receptor ... Progesterone receptor modulators with unique nonsteroidal structures are currently in the early stages of development (Fig. 5- ...
... growth hormone response element) IGF-1 and IGFBP-3 expression Via THR/THRE (thyroid hormone response element) Angiotensinogen ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... "The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration". Annals of the New York Academy of ... Then, it converts adenosine triphosphate into cyclic AMP, which activates Protein kinase A. PKA leads to protein tyrosine ...
Manganiello V, Evans WH, Stossel TP, Mason RJ, Vaughan M. The effect of polystyrene beads on cyclic AMP concentration in human ... Mechanical responses of white blood cells. In: Inflammation. Basic Mechanism and Clinical Correlates. J. Gallin, I. Goldstein, ... In: Cytoskeletal Elements and Plasma Membrane Organization, Poste G, Nicolson GL, eds, Elsevier, Amsterdam, 1981; 140-168. 41. ... pGSN is a master regulator-a key immune modulator that balances the inflammatory process to prevent the spread of excess ...
"Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally ... immune response. • nociception. • inflammatory response. • negative regulation of inflammatory response. • signal transduction ... Cannabinoid receptor modulators. Receptor. (ligands). CB1. *Agonists (abridged; see here for more): 2-AG ... response to amphetamine. • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger. • ...
This activates it, giving it the ability to catalyse substrate phosphorylation.[43] CREB (cAMP response element binding protein ... "Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system". ... which has been shown to be a cellular growth factor modulator with met-enkephalin being the endogenous ligand. This receptor is ... The CREB protein binds to cAMP response elements CRE, and can either increase or decrease the transcription of certain genes. ...
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor.[7] Phosphorylated CREB ... Negative allosteric modulators: VM-902A. *Kinase inhibitors: Altiratinib. *AZD-6918. *CE-245677 ... "Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease". JAMA Neurology. 72 (10): 1139-47. ...
... production of cyclic AMP [cAMP]);[5] e) G proteins types to which they link and activate, i.e. those containing the Gs alpha ... and cAMP response element-binding protein (CREB) which when activated phosphorylate and thereby influence the activity of key ... Prostanoid signaling modulators. Receptor. (ligands). DP (D2). DP1. *Agonists: Prostaglandin D2 ...
... and adenyl cyclase converts AMP into cyclic AMP (cAMP) thereby down-regulating cAMP-responsive proteins involved in cell ... immune response. • neuropeptide signaling pathway. • calcium-mediated signaling. • negative regulation of male germ cell ... DP2 activation also stimulates eosinophils and basophils to release the many pro-allergic elements of their granules to the ... Receptor/signaling modulators. Leukotriene signaling modulators. Nuclear receptor modulators. Retrieved from "https://en. ...
Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP Response Element Modulator. Subscribe to New Research on Cyclic AMP Response Element Modulator ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... cAMP Responsive Element Modulator; cAMP-Responsive Element Modulator ...
Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis. Sigrun R. ...
... which can bind the cyclic AMP response element binding (CREB) and cyclic AMP response element modulator (CREM) transcription ... Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T ... We previously showed that the expression of the transcriptional repressor cyclic AMP response element modulator α (CREMα) is ... 2005) The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM ...
"Cyclic AMP Response Element Modulator" by people in this website by year, and whether "Cyclic AMP Response Element Modulator" ... Cyclic AMP Response Element Modulator. *Cyclic AMP Response Element-Binding Protein. *Cyclic AMP Response Element-Binding ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... "Cyclic AMP Response Element Modulator" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ...
... The transcription factor cAMP-response element modulator (CREM) protein, plays a major role in cAMP-responsive gene regulation ... of CREM spliced variants is likely to have important ramifications on the regulation of downstream cAMP-response element- ...
Cyclic AMP Response Element Modulator * Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ... The potentially relevant genes that were elevated (15% to 28%) were P protein, LCK, cAMP responsive element modulator, IL-7 ...
Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser- ... of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements ( ... Cyclic AMP Response Element Modulator * DNA / metabolism * DNA, Complementary * DNA-Binding Proteins / genetics ... Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser- ...
The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to ... Mice overexpressing cyclic AMP-responsive element modulator α (CREMα) in T cells are characterised by enhanced production of ... The cyclic AMP (cAMP)-responsive element modulator (CREM) belongs to the family of basic leucine zipper transcription factors. ... Antisense cyclic adenosine 5-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic ...
The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. ... Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses ... Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor ... H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response. ...
cyclic AMP response element modulator. ESC. embryonic stem cell. IAP. intracisternal A particle. IMC. inter-mitochondrial ... Cyclic adenosine monophosphate response element modulator (CREM) and TRF2, key transcription factors for spermiogenesis, are ... The phenotype of these mutants is similar to that of the mutant for cAMP response element modulator (CREM), a master ... P element-induced wimpy testis. Q-PCR. quantitative PCR. ROSI. round spermatid injection. sDMA. symmetric dimethylated arginine ...
The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We ... Cyclic AMP Response Element Modulator / drug effects, metabolism*. DNA Fragmentation. Diabetes Mellitus, Experimental / ... 0/CREBBP protein, human; 0/Crebbp protein, rat; 0/Insulin; 0/Ubiquitin; 135844-64-3/Cyclic AMP Response Element Modulator; 50- ... The cAMP-responsive element?binding protein (CREB) is a transcription factor that binds to the cAMP response element within the ...
K. Tenbrock, V. C. Kyttaris, M. Ahlmann et al., "The cyclic AMP response element modulator regulates transcription of the TCR ... Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus. Qian Guo ... V. C. Kyttaris, Y. Wang, Y.-T. Juang, A. Weinstein, and G. C. Tsokos, "CAMP response element modulator α expression in patients ... T. Rauen, K. Benedyk, Y.-T. Juang et al., "A novel intronic cAMP response element modulator (CREM) promoter is regulated by ...
The Cyclic AMP Response Element Modulator Regulates Transcription of the TCR ζ-Chain Klaus Tenbrock, Vasileios C. Kyttaris, ... Osteopontin Is Not Required for the Development of Th1 Responses and Viral Immunity Brian Abel, Stefan Freigang, Martin F. ... Distinct Regulation of H2-M3-Restricted Memory T Cell Responses in Lymph Node and Spleen Alexander Ploss, Ingrid Leiner and ... Cutting Edge: Early IFN-γ Signaling Directly Enhances Primary Antiviral CD4+ T Cell Responses Jason K. Whitmire, Nicola Benning ...
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
2012). Cyclic AMP response element modulator-1 (CREM-1) involves in Neuronal Apoptosis after Traumatic brain injury. J. Mol. ... Zick, Y., Eisenstein, M., Goren, R. A., Hadari, Y. R., Levy, Y., and Ronen, D. (2004). Role of galectin-8 as a modulator of ... The phase contrast images in the panel illustrate the response of PC12 cells on PLL after applying a hyperosmotic shock (15 min ... We were able to dissect potential nanotopography-sensitive key elements regulated within a mechanotransductive sequence, ...
"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. doi: ...
Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ...
124 - Wu, X., et al., Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain ... early growth response (Egr) factor protein, nuclear factor kappa B (NF-κB) protein, and cAMP response element-binding (CREB) ... 43 - Cernak, I., et al., Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma ... 125 - Sandhir, R. and N.E. Berman, Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury ...
Moulton, V.R.; Holcomb, D.R.; Zajdel, M.C.; Tsokos, G.C. Estrogen upregulates cyclic AMP response element modulator alpha ... In vitro-activated human lupus T cells express normal estrogen receptor proteins which bind to the estrogen response element. ... Yeh, Y.C.; Yen, H.R.; Jiang, R.S.; Wang, R.C.; Huang, W.C.; Chen, S.C.; Lin, B.S.; Liang, K.L. Dose-response relationship of ... Sex Hormone Influences on the Induction of CD4+ T Cell-Mediated Immune Responses. CD4+ T helper (Th) cells are the major T cell ...
... of downstream targets including dopamine and cyclic-AMP regulated phosphoprotein of 32 kDa and cyclic-AMP-response element ... Ivermectin, an allosteric modulator of P2X4Rs, significantly affected dopamine and cyclic AMP regulated phosphoprotein of 32 ... Ivermectin (IVM), a positive modulator of P2X4Rs, enhanced levodopa (L-DOPA)-induced motor behavior. These studies highlight ...
The switch in alternative splicing of cyclic AMP-response element modulator protein CREMτ2α (activator) to CREMα (repressor) in ... Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2 ... The role of cAMP-response element binding (CREB) and modulator (CREMα and CREMτ2α) proteins. Journal of Molecular Endocrinology ... Can cobalt from metal-on-metal joints activate human TLR4 and cause an inflammatory response?. Bone and Joint Journal 2014, 96- ...
Y. Xu, C. Cui, C. Pang, Y. Christen, and Y. Luo, "Restoration of impaired phosphorylation of cyclic AMP response element- ... age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding ... Botanicals as Modulators of Neuroplasticity: Focus on BDNF. Enrico Sangiovanni, Paola Brivio, Mario DellAgli, and Francesca ... D. Miyazawa, Y. Yasui, K. Yamada, N. Ohara, and H. Okuyama, "Regional differences of the mouse brain in response to an α- ...
cAMP-response element. CREB. Cyclic AMP-responsive element-binding protein 1. CREM. cAMP-responsive element modulators ... Scobey MJ, Bertera S, Somers JP et al (2001) Delivery of a cyclic adenosine 3′,5′-monophosphate response element-binding ... Kangasniemi M, Kaipia A, Mali P et al (1990) Modulation of basal and FSH-dependent cyclic AMP production in rat seminiferous ... Fix C, Jordan C, Cano P, Walker WH (2004) Testosterone activates mitogen-activated protein kinase and the cAMP response element ...
Cyclic AMP Response Element Modulator * Panic Disorder * Genes * Haplotypes * Single Nucleotide Polymorphism ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ...
... cyclic AMP-dependent transcription factor ATF-6 beta K09052 CREM; cAMP response element modulator K09053 ATF1; activating ... 100477711 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 100465448 CREB3L3; cyclic AMP-responsive element- ... 100472104 CREB3; cyclic AMP-responsive element-binding protein 3 100470867 CREB3L1; cyclic AMP-responsive element-binding ... cyclic AMP-responsive element-binding protein 1 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ...
No maternal behavior phenotype was present in mice with a null mutation of the cyclic AMP response element modulator (Crem) ... The cyclic AMP response element (CRE) is found in many cellular genes regulated by cyclic AMP, and similar elements are present ... A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in ... Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior. Jin, S.H., Blendy, J.A., Thomas ...
... cyclic AMP-dependent transcription factor ATF-6 beta K09052 CREM; cAMP response element modulator K09053 ATF1; activating ... cyclic AMP-responsive element-binding protein 1 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ... cyclic AMP-responsive element-binding protein 3 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ... cyclic AMP-responsive element-binding protein 3 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09049 ATF6B; ...
Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... cyclic AMP-response element binding protein (CREB)-mediated G6PD transcription. In vivo, infusion of aldosterone decreased ... In response to the alpha-adrenergic agonist phenylephrine, they show marked attenuation in the hypertrophic response compared ... Parasympathetic Response in Chick Myocytes and Mouse Heart is Controlled by SREBP The Journal of Clinical Investigation. Jan, ...
... the cyclic AMP (cAMP) response element (CRE)-binding protein (CREB) family, which includes ATF1, CREB1, and the cAMP response ... element modulator (CREM; ref. 24). Both ATF1 ( 25) and CREB1 ( 26) are expressed ubiquitously, whereas CREM ( 27) is highly ... Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 1988; 242: 1430-3. ... Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human ...
Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Wolf, S.F., ... Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis. Wilmanski, J ... To assess the responses of the Alzheimers brain to possible oxidative challenges, we assayed for glutathione, glucose-6- ...
  • 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. (curehunter.com)
  • We previously showed that the expression of the transcriptional repressor cyclic AMP response element modulator α (CREMα) is increased in SLE T cells and contributes to reduced IL-2 production. (springer.com)
  • The IL-2 promoter defines a consensus CRE site at position -180, which can bind the cyclic AMP response element binding (CREB) and cyclic AMP response element modulator (CREM) transcription factors. (springer.com)
  • The transcription factor cAMP-response element modulator (CREM) protein, plays a major role in cAMP-responsive gene regulation. (cshl.edu)
  • Furthermore we have recently reported that this change in the expression of CREM spliced variants is likely to have important ramifications on the regulation of downstream cAMP-response element-responsive target genes involved in uterine activity during gestation. (cshl.edu)
  • Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. (nih.gov)
  • The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to increased IL-17 expression in patients with autoimmune disorders. (bmj.com)
  • Unexpectedly, our study indicates that CREMα transgenic T cells shift chronic inflammation in Nemo Δhepa livers towards a protective Treg response. (bmj.com)
  • Mice overexpressing cyclic AMP-responsive element modulator α (CREMα) in T cells are characterised by enhanced production of interleukin 17 (IL-17), IL-21 and IL-22 as well as retinoid receptor-related orphan receptor gamma-t (RORγT), and have increased inflammatory response. (bmj.com)
  • Cyclic adenosine monophosphate response element modulator (CREM) and TRF2, key transcription factors for spermiogenesis, are expressed in Tdrd5 -deficient round spermatids, but their targets, including Prm1 / Prm2 / Tnp1 , are severely down-regulated, which indicates the importance of IMC/CB-mediated regulation for postmeiotic gene expression. (rupress.org)
  • A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus," Journal of Biological Chemistry , vol. 286, no. 37, pp. 32366-32372, 2011. (hindawi.com)
  • C. M. Hedrich, T. Rauen, and G. C. Tsokos, "cAMP-responsive element modulator (CREM) α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus," The Journal of Biological Chemistry , vol. 286, no. 50, pp. 43429-43436, 2011. (hindawi.com)
  • cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. (wikipedia.org)
  • The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009) CAMP responsive element modulator has been shown to interact with FHL5. (wikipedia.org)
  • The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes. (wikipedia.org)
  • Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. (beds.ac.uk)
  • Three transcription factors, including cAMP response element-binding protein (CREB), cAMP response element modulator (CREM), and activating transcription factor 1 (ATF1), can be phosphorylated by PKA and subsequently bind to cAMP response elements (CRE) in gene promoters, generally to activate gene transcription ( Sands and Palmer, 2008 ). (elifesciences.org)
  • Transcriptional responses to increased cAMP occur through activation of the cAMP response element-binding protein (CREB), cAMP response element modulator (CREM), and activating transcription factor 1 (ATF1) ( 9 ). (sciencemag.org)
  • To investigate whether the cyclic AMP-responsive element modulator α (CREMα) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. (cdc.gov)
  • 9 CAMP Responsive Element Modulator (CREM) Kits ELISA de 4 fabricants sont disponibles sur www.anticorps-enligne.fr. (anticorps-enligne.fr)
  • The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. (biomedsearch.com)
  • CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. (wikipedia.org)
  • Transcription factor cyclic AMP response element-binding protein (CREB) in embryonic cortical neurons is an important modulator of Brain-derived neurotrophic factor (BDNF) induced gene expression. (bvsalud.org)
  • The PKA signaling pathway plays an important role in protein secretion through the activation of cAMP, in fluid secretion through the elevation of intracellular calcium and in the activation of cAMP response element-binding protein (CREB), which is involved in these signaling cascades. (elsevier.com)
  • Here, we identify acetyl-lysine competitive inhibitors targeting the bromodomains of coactivators CREB (cyclic-AMP response element binding protein) binding protein (CBP) and E1A binding protein of 300 kDa (EP300) as potent enhancers of reprogramming. (nature.com)
  • Signaling through the cyclic adenosine monophosphate-dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. (sciencemag.org)
  • The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in numerous processes and is widely regarded as the "classical" second messenger signaling pathway. (sciencemag.org)
  • Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. (drugbank.ca)
  • cAMP is synthesized from adenosine triphosphate (ATP) by adenylyl cyclase and is broken down to 5′ AMP by a class of proteins known as phosphodiesterases (PDEs) ( 1 , 2 ). (sciencemag.org)
  • DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE) which results in the activation of genes . (bionity.com)
  • c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes. (childrensmercy.org)
  • The potentially relevant genes that were elevated (15% to 28%) were P protein, LCK, cAMP responsive element modulator, IL-7 receptor, matrix metalloproteinase-19, M130 antigen, and peptidyl-prolyl isomerase. (nih.gov)
  • Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). (nih.gov)
  • All primers pairs of the tested genes showed Inhibitors,Modulators,Libraries a similar amplification efficiency to the one used for the ACTIN gene which was used as reference. (inhibitorlibraries.com)
  • Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. (curehunter.com)
  • The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain," Journal of Immunology , vol. 175, no. 9, pp. 5975-5980, 2005. (hindawi.com)
  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. (wikipedia.org)
  • Besides the CRE elements, each TRE sequence includes an E box as a target sequence for the AP4 transcription factor. (biomedcentral.com)
  • AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). (drugbank.ca)
  • They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN. (uchicago.edu)
  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. (uniprot.org)
  • post-synaptic markers including dopamine receptors and phosphorylation of downstream targets including dopamine and cyclic-AMP regulated phosphoprotein of 32 kDa and cyclic-AMP-response element binding protein in different parts of the striatum. (nih.gov)
  • Ivermectin, an allosteric modulator of P2X4Rs, significantly affected dopamine and cyclic AMP regulated phosphoprotein of 32 kDa and extracellular regulated kinase1/2 phosphorylation in the striatum. (nih.gov)
  • Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. (drugbank.ca)
  • Principally, cAMP exerts its function through three major targets − cAMP-dependent protein kinase A (PKA), cyclic nucleotide-gated ion channels (CNGCs), and exchange protein directly activated by cAMP (Epac). (elifesciences.org)
  • cAMP has three direct intracellular targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). (sciencemag.org)
  • CNGCs, nonselective cation channels that open upon cyclic nucleotide binding, are particularly important in the olfactory and visual systems ( 3 ). (sciencemag.org)
  • Studies have shown that mice fed a nucleotide-free diet have both impaired humoral and cellular immune responses. (drugbank.ca)
  • This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). (beds.ac.uk)
  • Dioxin is thought to exert its biological and toxicological effects primarily by binding to the aryl hydrocarbon receptor (AhR, dioxin receptor) followed by nuclear translocation and binding to dioxin-responsive elements (DREs) in gene promoters (reviewed by Beischlag et al. (thefreelibrary.com)
  • Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus," The Journal of Biological Chemistry , vol. 286, no. 3, pp. 1795-1801, 2011. (hindawi.com)
  • FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. (umassmed.edu)
  • The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. (bionity.com)
  • 25-Dihydroxyvitamin D3 injection also abolished the effects of exercise on the consummate end-products of brain-derived neurotrophic factor action, i.e. cyclic AMP response element-binding protein and synapsin I, and modulated phosphorylated calmodulin protein kinase II, a signal transduction cascade downstream to brain-derived neurotrophic factor action that is important for learning and memory. (unboundmedicine.com)
  • Cyclic AMP-dependent protein kinases ( protein kinase A ) are activated by the signal chain coming from the G protein (that was activated by the LHCG-receptor) via adenylate cyclase and cyclic AMP (cAMP). (bionity.com)
  • The transduction of extracellular signals to intracellular responses is one of the most important and complicated aspects of cellular life. (sciencemag.org)
  • The presence of intracellular kinase inhibitor Belinostat Ca2 is required for E2 mediated dopamine efflux Although we have controlled for dopamine flux specifi cally through the DAT through the use of DAT and nore pinephrine selective transporter inhibitors, the addition of these inhibitors does not account for the possibility of exocytotic release of dopamine which is dependent on extracellular Inhibitors,Modulators,Libraries Ca2. (inhibitorlibraries.com)
  • However, the prior emptying Inhibitors,Modulators,Libraries of intracel lular stores of Ca2 with thapsigargin did reverse E2 medi ated dopamine efflux. (inhibitorlibraries.com)
  • Vesicular Inhibitors,Modulators,Libraries release of dopamine is not involved in E2 mediated dopamine efflux We then further examined the mechanisms involved in the E2 induced movement of dopamine to the outside of PC12 cells. (inhibitorlibraries.com)
  • Finally, we found that PGE2 stimulated the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs, thus providing mechanistic insight into how PGE2 signaling down-modulates RALDH. (ox.ac.uk)
  • adenosine is an important endogenous physiological modulator of heart function. (physiology.org)
  • Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. (biomedsearch.com)
  • We investigated the effects of mutating these -170 CRE and -150 CCAAT elements on the promoter activity regulated by three different modulators previously known to act through CRE: ATF-2, cAMP and E1a. (sussex.ac.uk)
  • This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus. (frontiersin.org)
  • The production of retinoic acid (RA) by dendritic cells (DCs) is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors, such as α4β7 and CCR9, upon T and B cell activation. (ox.ac.uk)
  • Cyclic AMP (cAMP), the second messenger, converts the binding of ligands with many different G-protein coupled receptors (GPCRs, also known as seven-transmembrane domain receptors) into various biological activities ( Sutherland, 1970 ). (elifesciences.org)
  • Clinical and animal studies suggest a role for pathways regulated by cyclic-AMP in anxiety. (elsevier.com)
  • Although the different levels of dietary fish and vegetable oils involved in this study affected the expression of some transcripts, the immune-related pathways and functions activated by the antiviral response of salmon MLCs in both groups were comparable overall. (biomedcentral.com)
  • RLR-, TLR-, MAPK- and IFN-associated pathways) activated by the antiviral response of salmon MLCs. (biomedcentral.com)
  • Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. (umassmed.edu)
  • Abnormal T cells orchestrate responses of multiple cellular components of the immune system either directly or through secretion of cytokines. (springer.com)
  • The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. (hindawi.com)
  • The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. (hindawi.com)
  • Women have stronger immune responses to infections and vaccination than men. (frontiersin.org)
  • Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women. (frontiersin.org)
  • Besides gender, sex hormones contribute to the development and activity of the immune system, accounting for differences in gender-related immune responses. (frontiersin.org)
  • Intriguingly, the same immune response shifts during pregnancy to "tolerate" the foreign fetus and prevent rejection. (frontiersin.org)
  • There is evidence that there are differences in the immune response in the male seahorse during the parental vs. mating phases with improved immunity during the parental stage ( 1 , 2 ). (frontiersin.org)
  • A "side-effect" of the stronger immune response is the higher propensity for developing autoimmune disease. (frontiersin.org)
  • Sex hormones not only control the reproductive system, but also regulate the development, and function of the immune response. (frontiersin.org)
  • Innate and adaptive, humoral and cell-mediated immune responses are impacted by hormones, and dysregulation of these mechanisms contribute to immune-mediated diseases including autoimmune disease ( 3 - 9 ). (frontiersin.org)
  • It has been known for some time that sex hormones influence the function and activity of the immune system and likely contribute to the sex-based differences in immune-mediated disease responses. (mdpi.com)
  • In general, these effects have resulted in adult females inducing a more efficient humoral-based immune response upon pathogen challenge, whereas males tend to mount a less efficient immune response [ 1 , 2 ]. (mdpi.com)
  • Given the role of PGE2 in regulating the development of RA-producing DCs, modulating this pathway may prove a novel means to control the development of gut-tropic immune responses. (ox.ac.uk)
  • A heterodimeric cytokine that plays a role in innate and adaptive immune responses. (harvard.edu)
  • Fatty acids, notably polyunsaturated fatty acids (PUFAs), play an important role in innate immune responses and the functions of immune cells (e.g. (biomedcentral.com)
  • AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. (drugbank.ca)
  • Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvation-induced immunosuppression, the enhancement of T-cell maturation and function, the enhancement of natural killer cell activity, the improvement of delayed cutaneous hypersensitivity, helping resistance to such infectious agents as Staphylococcus aureus and Candida albicans, and finally the modulation of T-cell responses toward type 1 CD4 helper lymphocytes or Th1 cells. (drugbank.ca)
  • These findings underscore the importance of PTHrP in response to growth plate irradiation and show the novel finding of a decrease in Bax expression with amifostine pretreatment. (labome.org)
  • Furthermore, the maturation of clock function seems to correlate with the appearance of rhythmic expression of these positive elements of the clock feedback loop. (uni-heidelberg.de)
  • The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1. (freepatentsonline.com)
  • 20. The expression system of claim 1, wherein the neuron-specific regulatory element is the synapsin promoter as set forth in FIG. 8 beginning at position 7 and ending at position 488. (freepatentsonline.com)
  • A tumor-specific endogenous repetitive element is induced by herpesviruses. (harvard.edu)
  • Twelve unique SNPs for these LTR sequences localized in regulatory and non-regulatory elements were identified. (biomedcentral.com)
  • AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. (drugbank.ca)
  • We infused 1,25-dihydroxyvitamin D3, a modulator of energy metabolism, directly into the hippocampus during 3 days of voluntary wheel running and measured its effects on brain-derived neurotrophic factor-mediated synaptic plasticity. (unboundmedicine.com)
  • Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity. (unboundmedicine.com)
  • Aims Cyclic AMP inhibits vascular clean muscle cell (VSMC) proliferation which is important in the aetiology of numerous vascular diseases. (ecologicalsgardens.com)
  • We and others have shown that SLE T cells display decreased capacity to produce IL-2, a cytokine crucial to the development of cytotoxic responses, regulatory T-cell function and activation-induced cell death (13). (springer.com)
  • Chromatin-modifying enzymes as modulators of reprogramming. (nature.com)
  • CCPA reduced this response by 47%, an action inhibited by the PLC inhibitor U-73122 and 8-cyclopentyl-1,3-dipropylxanthine. (physiology.org)
  • LPLI also suppresses the inflammatory response of LPS-induced inflammation of stem cells. (ncku.edu.tw)
  • These data provide additional evidence that oligodendrogenesis is differentially regulated in white matter and gray matter and implicate PLP/DM20 as a modulator of these differences. (labome.org)
  • Thus, differential maturation of key elements of the medaka clock mechanism depends on the developmental stage and the presence of the chorion. (uni-heidelberg.de)