Cyclic AMP Response Element Modulator: Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Response Elements: Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Centrioles: Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.Spermatids: Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.Germ Cells: The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.Pachytene Stage: The stage in the first meiotic prophase, following ZYGOTENE STAGE, when CROSSING OVER between homologous CHROMOSOMES begins.CREB-Binding Protein: A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.Activating Transcription Factor 1: An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Para-Aortic Bodies: Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.3' Flanking Region: The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located.Glyceraldehyde-3-Phosphate Dehydrogenases: Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.Glucosephosphate DehydrogenaseKnowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Glucosephosphate Dehydrogenase Deficiency: A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.Fluphenazine: A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.Chromatin: The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Epilepsy, Absence: A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Rats, Mutant Strains: Rats bearing mutant genes which are phenotypically expressed in the animals.Physicians: Individuals licensed to practice medicine.Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Kluyvera: A genus of gram-negative, facultatively anaerobic bacteria in the family ENTEROBACTERIACEAE. It is found in FOOD; SOIL; and SEWAGE; and is an opportunistic pathogen of humans.Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Waste Water: Contaminated water generated as a waste product of human activity.Ecotoxicology: The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.

CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes. (1/246)

Previously, we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain Fra-1, Fra-2, Jun B, Jun D and c-Jun proteins that bind to the AP-1 DNA binding sequence. Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells. Here, we have detected the CREB family proteins CREB and CREMalpha as additional participants in the AP-1 DNA binding complex in differentiating keratinocytes. AP-1 and CRE DNA binding activity correlated with the induction of CREB, CREMalpha and ATF-1 and CREB phosphorylation at ser133 (ser133 phospho-CREB) in the transition from basal to differentiating keratinocytes, but the activity of a CRE reporter remained unchanged. In contrast, the CRE reporter was activated in the presence of the dominant-negative (DN) CREB mutants, KCREB and A-CREB, proteins that dimerize with CREB family members and block their ability to bind to DNA. The increase in CRE reporter activity in the presence of these mutants suggests that CRE-mediated transcriptional activity is suppressed in keratinocytes through protein-protein interactions involving a factor that dimerizes with the CREB leucine zipper. In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct, transcriptional activity was also increased indicating that a CREB family member binds AP-1 sites and represses AP-1 transcriptional activity as well. Exogenous expression of the transcriptional repressor CREMalpha down-regulated both CRE and AP-1 reporters in keratinocytes suggesting that this factor may contribute to the suppression of AP-1 transcriptional activity observed in differentiating keratinocytes.  (+info)

Regulation of cAMP responsive element binding modulator isoforms in cultured rat ovarian granulosa cells. (2/246)

A pituitary glycoprotein hormone FSH stimulates ovarian granulosa cells to induce ovarian follicular development. In this study we identified rat ovarian genes that were rapidly induced by FSH in the cultured rat granulosa cells by means of subtraction cloning. Complementary DNA clones encoding cAMP responsive element binding modulator (CREM) were identified as one of the FSH inducible genes. Northern blotting and reverse transcription and polymerase chain reaction (RT-PCR) analyses revealed that only the repressor type of CREM gene products, ICER (inducible cAMP early repressor) isoforms, were induced by FSH treatment in cultured rat granulosa cells. The induction of ICER by FSH was mimicked by reagents known to increase intracellular cAMP levels, indicating that the induction is through cAMP and protein kinase A signal transduction system. Induction of ICER was also confirmed as the protein levels. Electrophoretic mobility shift assay of granulosa cell extracts with a radiolabeled double stranded oligonucleotide corresponding to somatostatin cAMP responsive element also revealed that only the ICER proteins were induced by FSH treatment, whereas levels of CREM proteins were nearly constant regardless of the FSH treatment. Our present study demonstrates that FSH-induced and cAMP-mediated induction and attenuation of transcriptional responses by CREM gene products may be a key mechanistic component for the granulosa cell differentiation and proliferation.  (+info)

Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. (3/246)

Neurotransmitter-driven activation of transcription factors is important for control of neuronal and neuroendocrine functions. We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). pCREB accumulates endogenously at the beginning of the dark period and declines during the second half of the night. Concomitant with this decline, the amount of ICER rises. The changing ratio between pCREB and ICER shapes the in vivo dynamics in mRNA and, thus, protein levels of arylalkylamine-N-acetyltransferase, the rate-limiting enzyme of melatonin synthesis. Consequently, a silenced ICER expression in pinealocytes leads to a disinhibited arylalkylamine-N-acetyltransferase transcription and a primarily enhanced melatonin synthesis.  (+info)

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (4/246)

Ubiquitin-mediated proteolysis controls diverse physiological processes in eukaryotes. However, few in vivo targets of the mammalian Cdc34 and Rad6 ubiquitin-conjugating enzymes are known. A yeast-based genetic assay to identify proteins that interact with human Cdc34 resulted in three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog. Transfection assays with mammalian cells demonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIgamma and hATF5. This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription. Consistent with these results, the endogenous ICER protein is elevated in cells which are null for murine Rad6B (mHR6B-/-) or transfected with dominant negative and antisense constructs of human CDC34. Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development. Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regulated manner, with distinctly different patterns for Cdc34 and the Cullin proteins in germ cells. The Cdc34 and Rad6B proteins are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modifications occur. Thus, the stability of specific mammalian transcription factors is the result of complex targeting by multiple ubiquitin-conjugating enzymes and may have an impact on cAMP-inducible gene regulation during both meiotic and mitotic cell cycles.  (+info)

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (5/246)

The p38/stress-activated protein kinase2 (p38/SAPK2) is activated by cellular stress and proinflammatory cytokines. Several transcription factors have been reported to be regulated by p38/SAPK2, and this kinase is involved in the control of expression of various genes. In human Jurkat T-cells, induction of the early growth response gene-1 (egr-1) by anisomycin is completely inhibited by SB203580, a specific inhibitor of p38/SAPK2a and -b. Northern blot and reporter gene experiments indicate that this block is at the level of mRNA biosynthesis. Using mutants of the egr-1 promoter, we demonstrate that a distal cAMP-responsive element (CRE; nucleotides -134 to -126) is necessary to control egr-1 induction by p38/SAPK2. Pull-down assays indicate that phospho-CRE binding protein (CREB) and phospho-activating transcription factor-1 (ATF1) bind to this element in a p38/SAPK2-dependent manner. In response to anisomycin, two known CREB kinases downstream to p38/SAPK2, MAPKAP kinase 2 (MK2) and mitogen- and stress-activated kinase 1 (MSK1), show increased activity. However, in MK2 -/- fibroblasts derived from mice carrying a disruption of the MK2 gene, the phosphorylation of CREB and ATF1 and the expression of egr-1 reach levels comparable with wild type cells. This finding excludes MK2 as an involved enzyme. We conclude that egr-1 induction by anisomycin is mediated by p38/SAPK2 and probably by MSK1. Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene.  (+info)

The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. (6/246)

We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs). We isolated two novel CREM isoforms (CREMDeltaQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six known isoforms (CREMtaualpha, CREMalpha, inducible cyclic AMP early repressor (ICER) I, ICER Igamma, CREM-17X, and CREM-17) from rat pancreatic islets and the RINm5F pancreatic beta-cell line. CREM isoforms functioned as efficient transcriptional activators or repressors to modulate insulin promoter activity by binding to all of the insulin CREs. The binding activity of repressors is higher than that of activators and suppressed not only basal activity but also activator-induced activities. Furthermore, CREM activator interacted directly with the transcription factor IID components hTAF(II)130 and TATA box-binding protein (TBP). These results suggest that the activation of the insulin gene transcription by CREM activator is mediated by not only direct binding to the CREs but also by recruiting transcription factor IID to the insulin promoter via its interaction with hTAF(II)130 and TBP. On the other hand, the CREM repressor ICER competitively interrupts the binding of the activators to CREs and does not interact with either TBP or hTAF(II)130; therefore, it might fail to stabilize the basal transcriptional machinery and repress transactivation.  (+info)

A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids. (7/246)

During murine spermatogenesis, beginning in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site. We had shown previously that a 796-bp genomic fragment that flanks the germ cell start site and contains two putative CRE (cyclic AMP-responsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase reporter gene in late pachytene spermatocytes and round spermatids of transgenic mice (N. L. Shaper, A. Harduin-Lepers, and J. H. Shaper, J. Biol. Chem. 269:25165-25171, 1994). We now report that in vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously undescribed 14-bp regulatory element (5'-GCCGGTTTCCTAGA-3') that is distinct from the two CRE-like sequences. This cis element is located 16 bp upstream of the germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (transcriptional activator in late pachytene spermatocytes and round spermatids 1). The presence of the Ets signature binding motif 5'-GGAA-3' on the bottom strand of the TASS-1 sequence (underlined sequence) suggests that TASS-1 is a novel member of the Ets family of transcription factors. Additional transgenic analyses established that an 87-bp genomic fragment containing the TASS-1 regulatory element was sufficient for correct germ cell-specific expression of the beta-galactosidase reporter gene. Furthermore, when the TASS-1 motif was mutated by transversion, within the context of the original 796-bp fragment, transgene expression was reduced 12- to 35-fold in vivo.  (+info)

Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. (8/246)

Rhythmic activity of arylalkylamine N-acetyltransferase (AANAT) determines melatonin synthesis in rat pineal gland. The transcriptional regulation of AANAT involves the activating and inhibiting transcription factors of the cyclic AMP (cAMP)-signaling pathway, cAMP response element-binding protein and inducible cAMP early repressor (ICER), respectively. Activation of this pathway is centered around norepinephrine, stimulating beta(1)-adrenergic receptors, but various other transmitters can modulate melatonin biosynthesis. To compare the transcriptional impact of norepinephrine with that of other neurotransmitters on melatonin synthesis, we determined ICER protein levels in pinealocytes and, in parallel, hormone secretion. The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production. Importantly, ICER protein induction required lower ligand concentrations than the induction of melatonin biosynthesis. Although neuropeptide Y, glutamate, and vasopressin altered norepinephrine-stimulated hormone production without affecting ICER levels, the activation of voltage-gated cation channels increased ICER without affecting hormone synthesis. Sensitivity and versatility of ICER induction in pinealocytes make these neuroendocrine cells a valuable model system in which to study molecular interactions determining a regulated gene expression.  (+info)

*CAMP responsive element modulator

Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...

*TAF4

"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. PMC ...

*ATF1

Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP- ... Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ...

*SPI1

Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... Spi-1 (PU.1) 5' UTR regulatory element GRCh38: Ensembl release 89: ENSG00000066336 - Ensembl, May 2017 GRCm38: Ensembl release ...

*Molecular and epigenetic mechanisms of alcoholism

Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... Poo, M.M. (2001). Neurotrophins as synaptic modulators. Nat Rev Neurosci, 2, 24-32 102. Yan, Q.S., Feng, M.J., Yan, S.E. (2005 ... Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ...

*CREB

Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many ... 170-6. ISBN 978-0-87893-697-7. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. ... The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'- ...

*Metabotropic glutamate receptor 4

Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic ... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW (Feb 2009). "Positive allosteric modulators of the metabotropic ... "Discovery of a potent, selective and in vivo active mGluR4 positive allosteric modulator". Probe Reports from the NIH Molecular ...

*Picornain 3C

Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... Hepatitis A 3C protease cleaves NEMO at the Q304 residue; NEMO is a NF-κB essential modulator responsible for activation of ... interferon (IFN) antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating ...

*Nav1.8

"PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP- ... Another modulator of Nav1.8 is the ε isoform of PKC. This isoform is activated by the inflammatory mediator bradykinin and ... which are elements of chronic pain. Nav1.8 knockout mice studies have shown that the channel is associated with inflammatory ... are different from other sensory neurons in that they have a low activating threshold and consequently increase their response ...

*Prostaglandin EP2 receptor

... induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a ... "Structural features of subtype-selective EP receptor modulators". Drug Discovery Today. 22 (1): 57-71. doi:10.1016/j.drudis. ... EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro- ... Kalinski P (2012). "Regulation of immune responses by prostaglandin E2". Journal of Immunology. 188 (1): 21-8. doi:10.4049/ ...

*Selective progesterone receptor modulator

3). In the nucleus the dimer interacts with progesterone hormone response element in the DNA causing upregulation or ... and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor". Molecular and Cellular Biology. ... Phytoprogestogen Selective androgen receptor modulator Selective estrogen receptor modulator Selective glucocorticoid receptor ... Progesterone receptor modulators with unique nonsteroidal structures are currently in the early stages of development (Fig. 5- ...

*Biochemical cascade

... growth hormone response element) IGF-1 and IGFBP-3 expression Via THR/THRE (thyroid hormone response element) Angiotensinogen ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... "The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration". Annals of the New York Academy of ... LXR response element) Expression of ApoE CETP, FAS and LPL Exocrine production of bile salts and other compounds Via LXR /LXRE ...

*Opioid receptor

CREB (cAMP response element binding protein) belongs to a family of transcription factors and is positioned in the nucleus of ... Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS (October 2015). "Mechanisms of cyclic AMP/protein ... which has been shown to be a cellular growth factor modulator with met-enkephalin being the endogenous ligand. This receptor is ... The CREB protein binds to cAMP response elements CRE, and can either increases of decreases the transcription of certain genes ...
3.0.CO;2-B. ISSN 1040-452X. PMID 10824972. Sassone-Corsi, P. (1998-08-01). "CREM: a master-switch governing male germ cells differentiation and apoptosis". Seminars in Cell & Developmental Biology. 9 (4): 475-482. doi:10.1006/scdb.1998.0200. ISSN 1084-9521. PMID 9813195. "CREM (cAMP responsive element modulator)". atlasgeneticsoncology.org. Retrieved 2016-10-16. Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology. 20 (22): 8613-22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166 . PMID 11046156. Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165-9. doi:10.1038/18237. PMID 10086359. Domschke, K.; Kuhlenbäumer, G.; Schirmacher, A.; Lorenzi, C.; Armengol, L.; DiBella, D.; Gratacos, M.; Garritsen, H. S.; Nöthen, M. M. (2003-02-01). "Human nuclear ...
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c-Jun enhancement of cyclic adenosine 3,5-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA.
CREB+CREM兔多克隆抗体(ab5803)可与小鼠, 大鼠, 鸡, 人样本反应并经WB, IHC, EMSA, ChIP, ICC/IF实验严格验证,被6篇文献引用并得到2个独立的用户反馈。
CREMĂ DE NOAPTE RESTRUCTURANTĂ CU CELULE STEM 50 ML Caracteristici: Un produs antiage concentrat, perfect pentru noapte, ce utilizează tehnologia
Human granulocytes are characterized by a variety of specific effector functions involved in host defense. Several widely expressed protein kinases have been implicated in the regulation of these effector functions. A polymerase chain reaction- based strategy was used to identify novel granulocyte-specific kinases.Anovel protein kinase complementary DNA with an open reading frame of 357 amino acids was identified with homology ... read more to calciumcalmodulin- dependent kinase I (CaMKI). This has been termed CaMKI-like kinase (CKLiK). Analysis of CKLiK messenger RNA (mRNA) expression in hematopoietic cells demonstrated an almost exclusive expression in human polymorphonuclear leukocytes (PMN). Up-regulation of CKLiK mRNA occurs during neutrophilic differentiation of CD341 stem cells. CKLiK kinase activity was dependent on Ca11 and calmodulin as analyzed by in vitro phosphorylation of cyclic adenosine monophosphate responsive element modulator (CREM). Furthermore, CKLiKtransfected cells treated ...
Alzheimers disease (AD) is a progressive neurodegenerative disease and the most common form of senile dementia. Recently, scientists have put significant effort into exploring the molecular mechanisms involved in the pathological processes leading to the disease. A vast number of studies have focused on understanding the nitric oxide (NO) signaling pathway, which culminates with the phosphorylation of the transcription factor cAMP-responsive element-binding protein (CREB) through the increase of the second messenger cyclic guanosine monophosphate (cGMP) and activation of cGMP-dependent protein kinase. This book chapter provides an overview of the progress being made in modulating the hippocampal synaptic transmissions, which are critical for learning and memory, by targeting the different components of the NO/cGMP/CREB phosphorylation signaling pathway. Furthermore, a description of recent research on this pathway through the use of phosphodiesterase inhibitors is emphasized.
Spermatogenesis is coordinated by the spatial and temporal expression of many transcriptional and posttranscriptional factors. The cyclic AMP-responsive element modulator (CREM) gene encodes both activator and repressor isoforms that act as transcription factors to regulate spermiogenesis. We found that the testis-expressed paralog of CstF-64, tauCstF-64 (gene symbol Cstf2t), is involved in a polyadenylation site choice switch of Crem mRNA and leads to an overall decrease of the Crem mRNAs that are generated from internal promoters in Cstf2t(-/-) mice. More surprisingly, loss of tauCstF-64 also leads to alternative splicing of Crem exon 4, which contains an important activation domain. Thus, testis-specific CREMtau2 isoform protein levels are reduced in Cstf2t(-/-) mice. Consequently, expression of 15 CREM-regulated genes is decreased in testes of Cstf2t(-/-) mice at 25 days postpartum. These effects might further contribute to the infertility phenotype of these animals. This demonstrates that tauCstF
In type 2 diabetes, chronic hyperglycemia is detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We inves
Results Under basal conditions, freshly isolated T cells from active lupus patients had 2.3-fold higher miR-21 levels compared to healthy T cells. Combined anti-CD3/anti-CD28-stimulation induced higher miR-21 levels in SLE T cells than in controls (mean 4.0-fold vs 1.6-fold, respectively), suggesting aberrant regulation of miR-21 expression in SLE. PD-1 mRNA and miR21 levels correlated with disease activity. There was an inverse correlation between PD-1 mRNA and miR-21 levels in SLE patients (r2=−0.93) suggesting a co-regulation. This was documented by stimulating SLE T cells with anti-CD3/anti-CD28 in the presence or not of PDL1.Ig. PD-1 cross-linking reduced miR-21 levels by 45%. Moreover, silencing of PD-1, using a specific siRNA, was associated with 4.5-fold up-regulation of miR-21. Experiments are underway to elucidate the mechanisms of transcriptional regulation of miR-21 by mediators downstream to PD-1 and to correlate PD-1 genotypes with mir-21 expression.. ...
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Learn Skin System facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
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Washington, DC, February 1, 2017)-The National Pharmaceutical Council (NPC) commented on the Institute of Clinical and Economic Reviews (ICER) updated value assessment framework, which was released today.. "We recognize that developing frameworks is challenging and appreciate that ICER has made significant changes," said NPC President Dan Leonard. "We look forward to reviewing the updated framework in greater detail and understanding how these changes could work in practice.". NPC has remained engaged with ICER and offered constructive feedback to improve and evolve its framework. On initial review, ICER appears to have taken steps to improve the transparency and reproducibility of its economic models, formally included patient-centered factors into the framework, and considerably revised its approach to budget impact assessment by incorporating a range of potential product uptake rates and potential prices in its calculations. It also appears that ICER will no longer calculate a value-based ...
An ICER announcement that it will review a new drug can make drugmakers and patient groups worry. There are ways to work with ICER - and alternatives to it.
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TY - JOUR. T1 - Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene. AU - Di Rocco, Giuliana. AU - Pennuto, Maria. AU - Illi, Barbara. AU - Canu, Nadia. AU - Filocamo, Gessica. AU - Trani, Eugenia. AU - Rinaldi, Anna Maria. AU - Possenti, Roberta. AU - Mandolesi, Georgia. AU - Sirinian, M. Isabella. AU - Jucker, Richard. AU - Levi, Andrea. AU - Nasi, Sergio. PY - 1997/3. Y1 - 1997/3. N2 - vgf is a neurotrophin response-specific, developmentally regulated gene that codes for a neurosecretory polypeptide. Its transcription in neuronal cells is selectively activated by the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin 3, which induce survival and differentiation, and not by epidermal growth factor. We studied a short region of the rat vgf promoter which is essential for its regulated expression. A cyclic AMP response element (CRE) within this region is ...
China Custom-Made, Iml for Plastic Ice Crem Box, Find details about China in Mould Label, Heat Transfer from Custom-Made, Iml for Plastic Ice Crem Box - Taizhou City Liyang Package Co., Ltd.
I wanted to share my response to the ICER patient input questions. I definitely went into a lot of detail. Please do not feel you need write a book.
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Illumax whitening crem how long to beied - . The idea behind a colon cleanse process is to eliminate the toxins which have built up in your digestive system.
CREB3L1 antibody [C3], C-term (cAMP responsive element binding protein 3-like 1) for WB. Anti-CREB3L1 pAb (GTX104818) is tested in Human samples. 100% Ab-Assurance.
TY - JOUR. T1 - Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα. AU - Ruppert, Philip M.M.. AU - Park, Jong-Gil. AU - Xu, Xu. AU - Hur, Kyu Yeon. AU - Lee, Ann-Hwee. AU - Kersten, Sander. PY - 2019/3/11. Y1 - 2019/3/11. N2 - Background: Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wild-type, PPARα−/−, CREB3L3−/− and combined PPARα/CREB3L3−/− mice were subjected to a 16-h fast or 4 days of ketogenic diet. Whole genome expression analysis was performed on liver samples. Results: Under conditions of overnight fasting, the effects of PPARα ablation and CREB3L3 ablation on plasma ...
TransAM CREB and TransAM pCREB Kits are DNA-binding ELISAs that quanify the activated transcription factors using a method that is faster and more sensitive than gelshift, without radioactivity and gels.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016 ...
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
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Addiction Grayken Center for Addiction at Boston Medical Center Cardiology Cardiovascular Center Whitaker Cardiovascular Institute Center for Regenerative Medicine (CReM) George J. Murphy Lab
TY - JOUR. T1 - Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15. AU - Xie, Fuchun. AU - Fan, Qiuhua. AU - Li, Bingbing X.. AU - Xiao, Xiangshu. PY - 2019/1/1. Y1 - 2019/1/1. N2 - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, we designed an ester prodrug of 666-15 through a long-range O,N-acyl transfer reaction for improved aqueous solubility. Unexpectedly, we discovered a small molecule 11 (653-47) that can potentiate the CREB inhibitory activity of 666-15 although 653-47 alone does not inhibit CREB.. AB - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, ...
Expression of CREM (hCREM-2) in parathyroid gland tissue. Antibody staining with HPA001818 and CAB018352 in immunohistochemistry.
data a; run; ods graphics on; ods select DensityPanel; proc mcmc data=a stats=none diag=none nmc=10000 outpost=gout plots=density seed=1; parms gamma_3_is2 gamma_001_sc4 igamma_12_sc001 igamma_2_is01; prior gamma_3_is2 ~ gamma(shape=3, iscale=2); prior gamma_001_sc4 ~ gamma(shape=0.01, scale=4); prior igamma_12_sc001 ~ igamma(shape=12, scale=0.01); prior igamma_2_is01 ~ igamma(shape=2, iscale=0.1); model general(0); run; ods graphics off ...
Well i just wanted to take time out and wish everyone Happy Valentines Day. I hope everyone got to have there own special day. My day included my son (hes 4) giving me a valentines card. We made breafast together, and then went out to go shopping. Got alot of good deals for him on clothers as he will be starting school this year. He picked a stuffed animal for me and he picked some Ben 10 watch and accsessories for himself. I went and got my eyes checked and picked up my comntacts, and also dropped off my form for my disabled bus pass. I hope that works out, it will help alot in the long run. Well we came home, stopped and bought some ice crem and balloons and are going to finish the nite with movies. I love my son, hes my great little valentine!!! ...
Université de Rennes 1, CREM, Marsouin. Presentation at the conference organized by the "Groupe dIntérêt Scientifique: Culture-Media & Numerique", the Department of studies, forecasting, and statistics (ministry of Culture and Communication) and the "Innovation & Regulation in Digital Services" Chair (Ecole Polytechnique, Telecom ParisTech and Orange), in Paris, February 8th, 2011. This post is also available in: French ...

CAMP responsive element modulator - WikipediaCAMP responsive element modulator - Wikipedia

Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
more infohttps://en.wikipedia.org/wiki/CAMP_responsive_element_modulator

Cyclic AMP Response Element Modulator
     Summary Report | CureHunterCyclic AMP Response Element Modulator Summary Report | CureHunter

Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP Response Element Modulator. Subscribe to New Research on Cyclic AMP Response Element Modulator ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... cAMP Responsive Element Modulator; cAMP-Responsive Element Modulator ...
more infohttp://www.curehunter.com/public/keywordSummaryD051786.do

Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T...Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T...

... which can bind the cyclic AMP response element binding (CREB) and cyclic AMP response element modulator (CREM) transcription ... Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T ... We previously showed that the expression of the transcriptional repressor cyclic AMP response element modulator α (CREMα) is ... 2005) The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM ...
more infohttps://rd.springer.com/article/10.2119%2Fmolmed.2011.00506

The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha ...The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha ...

... The transcription factor cAMP-response element modulator (CREM) protein, plays a major role in cAMP-responsive gene regulation ... of CREM spliced variants is likely to have important ramifications on the regulation of downstream cAMP-response element- ...
more infohttp://repository.cshl.edu/22724/

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice | JCBTDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice | JCB

cyclic AMP response element modulator. ESC. embryonic stem cell. IAP. intracisternal A particle. IMC. inter-mitochondrial ... Cyclic adenosine monophosphate response element modulator (CREM) and TRF2, key transcription factors for spermiogenesis, are ... The phenotype of these mutants is similar to that of the mutant for cAMP response element modulator (CREM), a master ... P element-induced wimpy testis. Q-PCR. quantitative PCR. ROSI. round spermatid injection. sDMA. symmetric dimethylated arginine ...
more infohttp://jcb.rupress.org/content/192/5/781

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...

The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We ... Cyclic AMP Response Element Modulator / drug effects, metabolism*. DNA Fragmentation. Diabetes Mellitus, Experimental / ... 0/CREBBP protein, human; 0/Crebbp protein, rat; 0/Insulin; 0/Ubiquitin; 135844-64-3/Cyclic AMP Response Element Modulator; 50- ... The cAMP-responsive element?binding protein (CREB) is a transcription factor that binds to the cAMP response element within the ...
more infohttp://www.biomedsearch.com/nih/Degradation-cAMP-responsive-element-binding/19223597.html

Viemann D[au] - PubMed - NCBIViemann D[au] - PubMed - NCBI

The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. ... Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses ... Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor ... H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Viemann+D%5Bau%5D&dispmax=50

Frontiers | Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal...Frontiers | Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal...

2012). Cyclic AMP response element modulator-1 (CREM-1) involves in Neuronal Apoptosis after Traumatic brain injury. J. Mol. ... Zick, Y., Eisenstein, M., Goren, R. A., Hadari, Y. R., Levy, Y., and Ronen, D. (2004). Role of galectin-8 as a modulator of ... The phase contrast images in the panel illustrate the response of PC12 cells on PLL after applying a hyperosmotic shock (15 min ... We were able to dissect potential nanotopography-sensitive key elements regulated within a mechanotransductive sequence, ...
more infohttps://www.frontiersin.org/articles/10.3389/fncel.2017.00417/full

Memory Deficits and Transcription Factor Activity Following Traumatic Brain Injury | IntechOpenMemory Deficits and Transcription Factor Activity Following Traumatic Brain Injury | IntechOpen

124 - Wu, X., et al., Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain ... early growth response (Egr) factor protein, nuclear factor kappa B (NF-κB) protein, and cAMP response element-binding (CREB) ... 43 - Cernak, I., et al., Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma ... 125 - Sandhir, R. and N.E. Berman, Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury ...
more infohttps://www.intechopen.com/books/traumatic-brain-injury/memory-deficits-and-transcription-factor-activity-following-traumatic-brain-injury/

acute promyelocytic leukemia childhood 2005:2010[pubdate] *count=100 - BioMedLib™ search engineacute promyelocytic leukemia childhood 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Cyclic AMP Response Element-Binding Protein; 135844-64-3 / Cyclic AMP Response Element Modulator; EC 2.7.11.24 / Extracellular ... MeSH-major] Cyclic AMP Response Element Modulator / genetics. Gene Expression Regulation, Leukemic. Leukemia, Promyelocytic, ... Arsenic trioxide (ATO) has been studied in adults with newly diagnosed or relapsed APL with excellent response rates both when ... However, further well-designed case-control studies are necessary to determine the treatment response and prognosis in ...
more infohttp://www.bmlsearch.com/?kwr=acute+promyelocytic+leukemia+childhood+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Frontiers | Sex Hormones in Acquired Immunity and Autoimmune Disease | ImmunologyFrontiers | Sex Hormones in Acquired Immunity and Autoimmune Disease | Immunology

Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02279/full

IJMS  | Free Full-Text | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females | HTMLIJMS | Free Full-Text | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females | HTML

Moulton, V.R.; Holcomb, D.R.; Zajdel, M.C.; Tsokos, G.C. Estrogen upregulates cyclic AMP response element modulator alpha ... In vitro-activated human lupus T cells express normal estrogen receptor proteins which bind to the estrogen response element. ... Yeh, Y.C.; Yen, H.R.; Jiang, R.S.; Wang, R.C.; Huang, W.C.; Chen, S.C.; Lin, B.S.; Liang, K.L. Dose-response relationship of ... Sex Hormone Influences on the Induction of CD4+ T Cell-Mediated Immune Responses. CD4+ T helper (Th) cells are the major T cell ...
more infohttps://www.mdpi.com/1422-0067/19/6/1554/htm

Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus ErythematosusCyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus

K. Tenbrock, V. C. Kyttaris, M. Ahlmann et al., "The cyclic AMP response element modulator regulates transcription of the TCR ... Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus. Qian Guo ... V. C. Kyttaris, Y. Wang, Y.-T. Juang, A. Weinstein, and G. C. Tsokos, "CAMP response element modulator α expression in patients ... T. Rauen, K. Benedyk, Y.-T. Juang et al., "A novel intronic cAMP response element modulator (CREM) promoter is regulated by ...
more infohttps://www.hindawi.com/journals/jir/2015/906086/ref/

Staff Profile - Faculty of Medical Sciences - Newcastle UniversityStaff Profile - Faculty of Medical Sciences - Newcastle University

The switch in alternative splicing of cyclic AMP-response element modulator protein CREMτ2α (activator) to CREMα (repressor) in ... Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2 ... The role of cAMP-response element binding (CREB) and modulator (CREMα and CREMτ2α) proteins. Journal of Molecular Endocrinology ... Can cobalt from metal-on-metal joints activate human TLR4 and cause an inflammatory response?. Bone and Joint Journal 2014, 96- ...
more infohttps://www.ncl.ac.uk/medicalsciences/contact/team/profile/alisontyson-capper.html

Biology - Research Output
     - Montclair State UniversityBiology - Research Output - Montclair State University

Nuclear response to cyclic AMP: Central role of transcription factor CREM (cyclic-AMP-responsive-element modulator). Lalli, E ... Cell cycle regulation of cyclin A gene expression by the cyclic AMP- responsive transcription factors CREB and CREM. Desdouets ... Complexity and versatility of the transcriptional response to cAMP. Delmas, V., Molina, C., Lalli, E., de Groot, R., Foulkes, N ... Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response ...
more infohttps://researchwith.montclair.edu/en/organisations/biology/publications/?ordering=publicationYearThenTitle&descending=false

TAF4 - WikipediaTAF4 - Wikipedia

"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. PMC ...
more infohttps://en.wikipedia.org/wiki/TAF4

Protocols and Video Articles Authored by Ronglih Liao (Translated to Russian)Protocols and Video Articles Authored by Ronglih Liao (Translated to Russian)

Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... cyclic AMP-response element binding protein (CREB)-mediated G6PD transcription. In vivo, infusion of aldosterone decreased ... In response to the alpha-adrenergic agonist phenylephrine, they show marked attenuation in the hypertrophic response compared ... Parasympathetic Response in Chick Myocytes and Mouse Heart is Controlled by SREBP The Journal of Clinical Investigation. Jan, ...
more infohttps://www.jove.com/author/Ronglih_Liao?language=Russian

WikiGenes - G6PD - glucose-6-phosphate dehydrogenaseWikiGenes - G6PD - glucose-6-phosphate dehydrogenase

Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Wolf, S.F., ... Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis. Wilmanski, J ... To assess the responses of the Alzheimers brain to possible oxidative challenges, we assayed for glutathione, glucose-6- ...
more infohttps://www.wikigenes.org/e/gene/e/2539.html

Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in...Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in...

Autonomic cardiovascular responses to P + SOA at ambient PM2.5 levels were pronounced among MetS rats and indicated blunted ... Among ND rats, P + SOA decreased HRV only on day 1 and did not significantly alter BRS despite overall hypertensive responses ... Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction ... it is also possible a higher dose might elicit blunted responses per our hypothesized dose-response relationship. Consequently ...
more infohttps://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-017-0196-2

Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic...Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic...

The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to ... Mice overexpressing cyclic AMP-responsive element modulator α (CREMα) in T cells are characterised by enhanced production of ... The cyclic AMP (cAMP)-responsive element modulator (CREM) belongs to the family of basic leucine zipper transcription factors. ... Antisense cyclic adenosine 5-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic ...
more infohttps://gut.bmj.com/content/66/5/908

Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans. - Radcliffe...Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans. - Radcliffe...

Finally, we found that PGE2 stimulated the expression of the inducible cyclic AMP early repressor, which appears to directly ... modulating this pathway may prove a novel means to control the development of gut-tropic immune responses. ... is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors ... Animals, Cell Differentiation, Cell Line, Cyclic AMP Response Element Modulator, Dendritic Cells, Dinoprostone, Granulocyte- ...
more infohttps://www.rdm.ox.ac.uk/publications/127200

Botanicals as Modulators of Neuroplasticity: Focus on BDNFBotanicals as Modulators of Neuroplasticity: Focus on BDNF

Y. Xu, C. Cui, C. Pang, Y. Christen, and Y. Luo, "Restoration of impaired phosphorylation of cyclic AMP response element- ... age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding ... Botanicals as Modulators of Neuroplasticity: Focus on BDNF. Enrico Sangiovanni, Paola Brivio, Mario DellAgli, and Francesca ... D. Miyazawa, Y. Yasui, K. Yamada, N. Ohara, and H. Okuyama, "Regional differences of the mouse brain in response to an α- ...
more infohttps://www.hindawi.com/journals/np/2017/5965371/

WikiGenes - Response ElementsWikiGenes - Response Elements

No maternal behavior phenotype was present in mice with a null mutation of the cyclic AMP response element modulator (Crem) ... The cyclic AMP response element (CRE) is found in many cellular genes regulated by cyclic AMP, and similar elements are present ... A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in ... Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior. Jin, S.H., Blendy, J.A., Thomas ...
more infohttps://www.wikigenes.org/e/mesh/e/18779.html

Items where Year is 2005 - CSHL Scientific Digital RepositoryItems where Year is 2005 - CSHL Scientific Digital Repository

The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha ... Iijima-Ando, K., Wu, P., Drier, E. A., Iijima, K., Yin, J. C. P. (July 2005) cAMP-response element-binding protein and heat- ... Herbst, A., Hemann, M. T., Tworkowski, K. A., Salghetti, S. E., Lowe, S. W., Tansey, W. P. (February 2005) A conserved element ... Zhao, Z. Y., Fang, L., Chen, N. S., Johnsen, R. C., Stein, L., Baillie, D. L. (November 2005) Distinct regulatory elements ...
more infohttp://repository.cshl.edu/view/year/2005.html

Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response...Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response...

Cyclic AMP/physiology. *Cyclic AMP Response Element Modulator. *DNA-Binding Proteins/genetics* ... cAMP-responsive element modulator (CREM) expression is tissue specific and developmentally regulated. Here we report that CREM ... The kinetic of expression is characteristic of an early response gene. The induction is transient and cell specific, does not ... ICER binds to these elements and thereby represses the activity of its own promoter, thus constituting a negative ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8252624
  • Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus," The Journal of Biological Chemistry , vol. 286, no. 3, pp. 1795-1801, 2011. (hindawi.com)
  • This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus. (frontiersin.org)
  • ICER binds to these elements and thereby represses the activity of its own promoter, thus constituting a negative autoregulatory loop. (nih.gov)
  • We and others have shown that SLE T cells display decreased capacity to produce IL-2, a cytokine crucial to the development of cytotoxic responses, regulatory T-cell function and activation-induced cell death (13). (springer.com)
  • The production of retinoic acid (RA) by dendritic cells (DCs) is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors, such as α4β7 and CCR9, upon T and B cell activation. (ox.ac.uk)
  • In general, these effects have resulted in adult females inducing a more efficient humoral-based immune response upon pathogen challenge, whereas males tend to mount a less efficient immune response [ 1 , 2 ]. (mdpi.com)
  • The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. (hindawi.com)
  • Periodontal and systemic responses in various mice models of experimental periodontitis: respective roles of inflammation duration and Porphyromonas gingivalis infection. (labome.org)
  • The insulin secretion in response to glucose and the insulin content were preserved in human islets exposed to high glucose and loaded with the peptide. (biomedsearch.com)
  • The presence of intracellular kinase inhibitor Belinostat Ca2 is required for E2 mediated dopamine efflux Although we have controlled for dopamine flux specifi cally through the DAT through the use of DAT and nore pinephrine selective transporter inhibitors, the addition of these inhibitors does not account for the possibility of exocytotic release of dopamine which is dependent on extracellular Inhibitors,Modulators,Libraries Ca2. (inhibitorlibraries.com)
  • Vesicular Inhibitors,Modulators,Libraries release of dopamine is not involved in E2 mediated dopamine efflux We then further examined the mechanisms involved in the E2 induced movement of dopamine to the outside of PC12 cells. (inhibitorlibraries.com)
  • The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. (hindawi.com)