Cyclic AMP Response Element Modulator
Cyclic AMP Response Element-Binding Protein
Cyclic AMP
Promoter Regions, Genetic
Repressor Proteins
DNA-Binding Proteins
Response Elements
Transcription, Genetic
Atracurium
Multiple Sclerosis, Relapsing-Remitting
The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Multiple Sclerosis, Chronic Progressive
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
Interferon-beta
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Gene Expression
Spermatogenesis
Centrioles
Spermatids
Pachytene Stage
Testis
Spermatocytes
CREB-Binding Protein
Activating Transcription Factor 1
Transcription Factors
Phosphorylation
Encyclopedias as Topic
Molecular Biology
Developmental Biology
Panic Disorder
A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
Panic
Polymorphism, Single Nucleotide
Models, Genetic
Authorship
Journal Impact Factor
Video Games
3' Flanking Region
Publishing
Glyceraldehyde-3-Phosphate Dehydrogenases
Knowledge Bases
Glucosephosphate Dehydrogenase Deficiency
Glucose-6-Phosphatase
CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes. (1/246)
Previously, we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain Fra-1, Fra-2, Jun B, Jun D and c-Jun proteins that bind to the AP-1 DNA binding sequence. Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells. Here, we have detected the CREB family proteins CREB and CREMalpha as additional participants in the AP-1 DNA binding complex in differentiating keratinocytes. AP-1 and CRE DNA binding activity correlated with the induction of CREB, CREMalpha and ATF-1 and CREB phosphorylation at ser133 (ser133 phospho-CREB) in the transition from basal to differentiating keratinocytes, but the activity of a CRE reporter remained unchanged. In contrast, the CRE reporter was activated in the presence of the dominant-negative (DN) CREB mutants, KCREB and A-CREB, proteins that dimerize with CREB family members and block their ability to bind to DNA. The increase in CRE reporter activity in the presence of these mutants suggests that CRE-mediated transcriptional activity is suppressed in keratinocytes through protein-protein interactions involving a factor that dimerizes with the CREB leucine zipper. In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct, transcriptional activity was also increased indicating that a CREB family member binds AP-1 sites and represses AP-1 transcriptional activity as well. Exogenous expression of the transcriptional repressor CREMalpha down-regulated both CRE and AP-1 reporters in keratinocytes suggesting that this factor may contribute to the suppression of AP-1 transcriptional activity observed in differentiating keratinocytes. (+info)Regulation of cAMP responsive element binding modulator isoforms in cultured rat ovarian granulosa cells. (2/246)
A pituitary glycoprotein hormone FSH stimulates ovarian granulosa cells to induce ovarian follicular development. In this study we identified rat ovarian genes that were rapidly induced by FSH in the cultured rat granulosa cells by means of subtraction cloning. Complementary DNA clones encoding cAMP responsive element binding modulator (CREM) were identified as one of the FSH inducible genes. Northern blotting and reverse transcription and polymerase chain reaction (RT-PCR) analyses revealed that only the repressor type of CREM gene products, ICER (inducible cAMP early repressor) isoforms, were induced by FSH treatment in cultured rat granulosa cells. The induction of ICER by FSH was mimicked by reagents known to increase intracellular cAMP levels, indicating that the induction is through cAMP and protein kinase A signal transduction system. Induction of ICER was also confirmed as the protein levels. Electrophoretic mobility shift assay of granulosa cell extracts with a radiolabeled double stranded oligonucleotide corresponding to somatostatin cAMP responsive element also revealed that only the ICER proteins were induced by FSH treatment, whereas levels of CREM proteins were nearly constant regardless of the FSH treatment. Our present study demonstrates that FSH-induced and cAMP-mediated induction and attenuation of transcriptional responses by CREM gene products may be a key mechanistic component for the granulosa cell differentiation and proliferation. (+info)Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. (3/246)
Neurotransmitter-driven activation of transcription factors is important for control of neuronal and neuroendocrine functions. We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). pCREB accumulates endogenously at the beginning of the dark period and declines during the second half of the night. Concomitant with this decline, the amount of ICER rises. The changing ratio between pCREB and ICER shapes the in vivo dynamics in mRNA and, thus, protein levels of arylalkylamine-N-acetyltransferase, the rate-limiting enzyme of melatonin synthesis. Consequently, a silenced ICER expression in pinealocytes leads to a disinhibited arylalkylamine-N-acetyltransferase transcription and a primarily enhanced melatonin synthesis. (+info)Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (4/246)
Ubiquitin-mediated proteolysis controls diverse physiological processes in eukaryotes. However, few in vivo targets of the mammalian Cdc34 and Rad6 ubiquitin-conjugating enzymes are known. A yeast-based genetic assay to identify proteins that interact with human Cdc34 resulted in three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog. Transfection assays with mammalian cells demonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIgamma and hATF5. This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription. Consistent with these results, the endogenous ICER protein is elevated in cells which are null for murine Rad6B (mHR6B-/-) or transfected with dominant negative and antisense constructs of human CDC34. Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development. Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regulated manner, with distinctly different patterns for Cdc34 and the Cullin proteins in germ cells. The Cdc34 and Rad6B proteins are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modifications occur. Thus, the stability of specific mammalian transcription factors is the result of complex targeting by multiple ubiquitin-conjugating enzymes and may have an impact on cAMP-inducible gene regulation during both meiotic and mitotic cell cycles. (+info)Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (5/246)
The p38/stress-activated protein kinase2 (p38/SAPK2) is activated by cellular stress and proinflammatory cytokines. Several transcription factors have been reported to be regulated by p38/SAPK2, and this kinase is involved in the control of expression of various genes. In human Jurkat T-cells, induction of the early growth response gene-1 (egr-1) by anisomycin is completely inhibited by SB203580, a specific inhibitor of p38/SAPK2a and -b. Northern blot and reporter gene experiments indicate that this block is at the level of mRNA biosynthesis. Using mutants of the egr-1 promoter, we demonstrate that a distal cAMP-responsive element (CRE; nucleotides -134 to -126) is necessary to control egr-1 induction by p38/SAPK2. Pull-down assays indicate that phospho-CRE binding protein (CREB) and phospho-activating transcription factor-1 (ATF1) bind to this element in a p38/SAPK2-dependent manner. In response to anisomycin, two known CREB kinases downstream to p38/SAPK2, MAPKAP kinase 2 (MK2) and mitogen- and stress-activated kinase 1 (MSK1), show increased activity. However, in MK2 -/- fibroblasts derived from mice carrying a disruption of the MK2 gene, the phosphorylation of CREB and ATF1 and the expression of egr-1 reach levels comparable with wild type cells. This finding excludes MK2 as an involved enzyme. We conclude that egr-1 induction by anisomycin is mediated by p38/SAPK2 and probably by MSK1. Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene. (+info)The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. (6/246)
We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs). We isolated two novel CREM isoforms (CREMDeltaQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six known isoforms (CREMtaualpha, CREMalpha, inducible cyclic AMP early repressor (ICER) I, ICER Igamma, CREM-17X, and CREM-17) from rat pancreatic islets and the RINm5F pancreatic beta-cell line. CREM isoforms functioned as efficient transcriptional activators or repressors to modulate insulin promoter activity by binding to all of the insulin CREs. The binding activity of repressors is higher than that of activators and suppressed not only basal activity but also activator-induced activities. Furthermore, CREM activator interacted directly with the transcription factor IID components hTAF(II)130 and TATA box-binding protein (TBP). These results suggest that the activation of the insulin gene transcription by CREM activator is mediated by not only direct binding to the CREs but also by recruiting transcription factor IID to the insulin promoter via its interaction with hTAF(II)130 and TBP. On the other hand, the CREM repressor ICER competitively interrupts the binding of the activators to CREs and does not interact with either TBP or hTAF(II)130; therefore, it might fail to stabilize the basal transcriptional machinery and repress transactivation. (+info)A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids. (7/246)
During murine spermatogenesis, beginning in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site. We had shown previously that a 796-bp genomic fragment that flanks the germ cell start site and contains two putative CRE (cyclic AMP-responsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase reporter gene in late pachytene spermatocytes and round spermatids of transgenic mice (N. L. Shaper, A. Harduin-Lepers, and J. H. Shaper, J. Biol. Chem. 269:25165-25171, 1994). We now report that in vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously undescribed 14-bp regulatory element (5'-GCCGGTTTCCTAGA-3') that is distinct from the two CRE-like sequences. This cis element is located 16 bp upstream of the germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (transcriptional activator in late pachytene spermatocytes and round spermatids 1). The presence of the Ets signature binding motif 5'-GGAA-3' on the bottom strand of the TASS-1 sequence (underlined sequence) suggests that TASS-1 is a novel member of the Ets family of transcription factors. Additional transgenic analyses established that an 87-bp genomic fragment containing the TASS-1 regulatory element was sufficient for correct germ cell-specific expression of the beta-galactosidase reporter gene. Furthermore, when the TASS-1 motif was mutated by transversion, within the context of the original 796-bp fragment, transgene expression was reduced 12- to 35-fold in vivo. (+info)Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. (8/246)
Rhythmic activity of arylalkylamine N-acetyltransferase (AANAT) determines melatonin synthesis in rat pineal gland. The transcriptional regulation of AANAT involves the activating and inhibiting transcription factors of the cyclic AMP (cAMP)-signaling pathway, cAMP response element-binding protein and inducible cAMP early repressor (ICER), respectively. Activation of this pathway is centered around norepinephrine, stimulating beta(1)-adrenergic receptors, but various other transmitters can modulate melatonin biosynthesis. To compare the transcriptional impact of norepinephrine with that of other neurotransmitters on melatonin synthesis, we determined ICER protein levels in pinealocytes and, in parallel, hormone secretion. The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production. Importantly, ICER protein induction required lower ligand concentrations than the induction of melatonin biosynthesis. Although neuropeptide Y, glutamate, and vasopressin altered norepinephrine-stimulated hormone production without affecting ICER levels, the activation of voltage-gated cation channels increased ICER without affecting hormone synthesis. Sensitivity and versatility of ICER induction in pinealocytes make these neuroendocrine cells a valuable model system in which to study molecular interactions determining a regulated gene expression. (+info)
POST-TRANSLATIONAL REGULATION OF INDUCIBLE CAMP EARLY REPRESSOR AND ITS IMPLICATIONS IN CANCER
- Montclair State University
CAMP responsive element modulator - Wikipedia
Investigation of Polymorphisms in the CREM Gene in Panic Disorder<...
Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of...
Lentiviral delivered siRNA against ICER protects primary cortical neurons from apoptosis caused by serum depriviation - Acta...
OriGene - Crem (NM 001110859) Human ORF cDNA Clone
OriGene - CREM (NM 182723) Human ORF cDNA Clone
Recombinant Human CREM protein (ab158197) | Abcam
c-Jun enhancement of cyclic adenosine 3,5-monophosphate response element-dependent transcription induced by transforming...
CREB + CREM抗体|Abcam中国|Anti-CREB + CREM抗体
CREMĂ DE NOAPTE RESTRUCTURANTĂ | Ecovitalshop
Identification and characterization of CKLiK, a novel granulocyteCa^(++)/calmodulin-dependent kinase
Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma |...
Targeting the NO/cGMP/CREB Phosphorylation Signaling Pathway in Alzheimers Disease | IntechOpen
ICER Update 05.06.19 | Excelsior Solutions
Body Crem Givrine : a fresh floral
TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activ by Petar N Grozdanov, Atia Amatullah et al.
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...
Regulation of T cell hyperactivity in SLE: the negative co-stimulatory molecule PD-1 regulates miR-21 expression in SLE T...
CREM - PrimePCR Assay and Template | Life Science | Bio-Rad
Cremè Fillings | MGP
Learn: Skin System (by icer215) - Memorize.com - Remember and Understand
Kiddy Shop: Au revenit produsele Weleda + un produs nou pentru baie
IDC Events - Western Europe
National Pharmaceutical Council Comments on Revised ICER Value Assessment Framework | National Pharmaceutical Council
Supplement to Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in...
Working with ICER, or around it, on cost-effectiveness estimates - STAT
Cystic Fibrosis: Final Evidence Report - ICER
Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific,...
China Custom-Made, Iml for Plastic Ice Crem Box - China in Mould Label, Heat Transfer
Migraine Patient Input for ICER Report - My Submission ⋆ Golden Graine
The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization, Co...
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anti-CREB3L1 antibody [C3], C-term | GeneTex
Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic...
Active Motif » TransAM CREB (cyclic AMP response element binding, CREB and Phosphorylated CREB (Ser133) DNA binding ELISAs)
Prostate Cancer: Final Report | ICER
Paired mesoderm homeobox protein 2B
crebl2 Protein, cAMP responsive element binding protein-like 2 - Creative BioMart
ICER Atopic Dermatitis Review Prompted By First Biologic :: Scrip
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Boston Medical Center Receives $2.7 Million Grant
Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...
Tissue expression of CREM - Staining in parathyroid gland - The Human Protein Atlas
camp response element -> Attachments -...
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People magazine
TAF4
"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. doi: ...
ATF1
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP- ... Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ...
SPI1
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ...
CAMP responsive element modulator
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
Molecular and epigenetic mechanisms of alcoholism
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... Poo, M.M. (2001). Neurotrophins as synaptic modulators. Nat Rev Neurosci, 2, 24-32 102. Yan, Q.S., Feng, M.J., Yan, S.E. (2005 ... Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ...
CREB
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many ... The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'- ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ...
Follicle-stimulating hormone receptor
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Small-molecule positive allosteric modulators of the FSHR have been developed. Alfred G. Gilman and Martin Rodbell received the ... For a cell to respond to FSH, only a small percentage (~1%) of receptor sites need to be activated.[citation needed] Cyclic AMP ... The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. ...
Luteinizing hormone/choriogonadotropin receptor
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators • GnRH and gonadotropins ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. ...
Picornain 3C
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... Hepatitis A 3C protease cleaves NEMO at the Q304 residue; NEMO is a NF-κB essential modulator responsible for activation of ... interferon (IFN) antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating ...
Metabotropic glutamate receptor 4
Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic ... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW (Feb 2009). "Positive allosteric modulators of the metabotropic ... Beqollari D, Kammermeier PJ (Jul 2008). "The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b] ...
Prostaglandin EP2 receptor
... induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a ... "Structural features of subtype-selective EP receptor modulators". Drug Discovery Today. 22 (1): 57-71. doi:10.1016/j.drudis. ... EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro- ... A 2021 study found that inhibition of myeloid cell EP2 signalling can reverse or prevent an inflammation element of brain- ...
Selective progesterone receptor modulator
3). In the nucleus the dimer interacts with progesterone hormone response element in the DNA causing upregulation or ... and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor". Molecular and Cellular Biology. ... Phytoprogestogen Selective androgen receptor modulator Selective estrogen receptor modulator Selective glucocorticoid receptor ... Progesterone receptor modulators with unique nonsteroidal structures are currently in the early stages of development (Fig. 5- ...
Biochemical cascade
... growth hormone response element) IGF-1 and IGFBP-3 expression Via THR/THRE (thyroid hormone response element) Angiotensinogen ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... "The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration". Annals of the New York Academy of ... Then, it converts adenosine triphosphate into cyclic AMP, which activates Protein kinase A. PKA leads to protein tyrosine ...
Thomas P. Stossel
Manganiello V, Evans WH, Stossel TP, Mason RJ, Vaughan M. The effect of polystyrene beads on cyclic AMP concentration in human ... Mechanical responses of white blood cells. In: Inflammation. Basic Mechanism and Clinical Correlates. J. Gallin, I. Goldstein, ... In: Cytoskeletal Elements and Plasma Membrane Organization, Poste G, Nicolson GL, eds, Elsevier, Amsterdam, 1981; 140-168. 41. ... pGSN is a master regulator-a key immune modulator that balances the inflammatory process to prevent the spread of excess ...
Cannabinoid receptor type 2
"Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally ... immune response. • nociception. • inflammatory response. • negative regulation of inflammatory response. • signal transduction ... Cannabinoid receptor modulators. Receptor. (ligands). CB1. *Agonists (abridged; see here for more): 2-AG ... response to amphetamine. • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger. • ...
Opioid receptor
This activates it, giving it the ability to catalyse substrate phosphorylation.[43] CREB (cAMP response element binding protein ... "Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system". ... which has been shown to be a cellular growth factor modulator with met-enkephalin being the endogenous ligand. This receptor is ... The CREB protein binds to cAMP response elements CRE, and can either increase or decrease the transcription of certain genes. ...
Nerve growth factor
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor.[7] Phosphorylated CREB ... Negative allosteric modulators: VM-902A. *Kinase inhibitors: Altiratinib. *AZD-6918. *CE-245677 ... "Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease". JAMA Neurology. 72 (10): 1139-47. ...
Prostaglandin receptor
... production of cyclic AMP [cAMP]);[5] e) G proteins types to which they link and activate, i.e. those containing the Gs alpha ... and cAMP response element-binding protein (CREB) which when activated phosphorylate and thereby influence the activity of key ... Prostanoid signaling modulators. Receptor. (ligands). DP (D2). DP1. *Agonists: Prostaglandin D2 ...
Prostaglandin DP2 receptor
... and adenyl cyclase converts AMP into cyclic AMP (cAMP) thereby down-regulating cAMP-responsive proteins involved in cell ... immune response. • neuropeptide signaling pathway. • calcium-mediated signaling. • negative regulation of male germ cell ... DP2 activation also stimulates eosinophils and basophils to release the many pro-allergic elements of their granules to the ... Receptor/signaling modulators. Leukotriene signaling modulators. Nuclear receptor modulators. Retrieved from "https://en. ...
Cyclic AMP Response Element Modulator
Summary Report | CureHunter
Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP Response Element Modulator. Subscribe to New Research on Cyclic AMP Response Element Modulator ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... cAMP Responsive Element Modulator; cAMP-Responsive Element Modulator ...
Supplement to Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in...
Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T...
... which can bind the cyclic AMP response element binding (CREB) and cyclic AMP response element modulator (CREM) transcription ... Estrogen Upregulates Cyclic AMP Response Element Modulator α Expression and Downregulates Interleukin-2 Production by Human T ... We previously showed that the expression of the transcriptional repressor cyclic AMP response element modulator α (CREMα) is ... 2005) The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM ...
Cyclic AMP Response Element Modulator | Profiles RNS
"Cyclic AMP Response Element Modulator" by people in this website by year, and whether "Cyclic AMP Response Element Modulator" ... Cyclic AMP Response Element Modulator. *Cyclic AMP Response Element-Binding Protein. *Cyclic AMP Response Element-Binding ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... "Cyclic AMP Response Element Modulator" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ...
The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha ...
In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with...
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene...
Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser- ... of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements ( ... Cyclic AMP Response Element Modulator * DNA / metabolism * DNA, Complementary * DNA-Binding Proteins / genetics ... Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser- ...
Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic...
The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to ... Mice overexpressing cyclic AMP-responsive element modulator α (CREMα) in T cells are characterised by enhanced production of ... The cyclic AMP (cAMP)-responsive element modulator (CREM) belongs to the family of basic leucine zipper transcription factors. ... Antisense cyclic adenosine 5-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic ...
Viemann D[au] - PubMed - NCBI
The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. ... Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses ... Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor ... H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response. ...
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice | JCB
cyclic AMP response element modulator. ESC. embryonic stem cell. IAP. intracisternal A particle. IMC. inter-mitochondrial ... Cyclic adenosine monophosphate response element modulator (CREM) and TRF2, key transcription factors for spermiogenesis, are ... The phenotype of these mutants is similar to that of the mutant for cAMP response element modulator (CREM), a master ... P element-induced wimpy testis. Q-PCR. quantitative PCR. ROSI. round spermatid injection. sDMA. symmetric dimethylated arginine ...
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...
The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We ... Cyclic AMP Response Element Modulator / drug effects, metabolism*. DNA Fragmentation. Diabetes Mellitus, Experimental / ... 0/CREBBP protein, human; 0/Crebbp protein, rat; 0/Insulin; 0/Ubiquitin; 135844-64-3/Cyclic AMP Response Element Modulator; 50- ... The cAMP-responsive element?binding protein (CREB) is a transcription factor that binds to the cAMP response element within the ...
Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus
K. Tenbrock, V. C. Kyttaris, M. Ahlmann et al., "The cyclic AMP response element modulator regulates transcription of the TCR ... Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus. Qian Guo ... V. C. Kyttaris, Y. Wang, Y.-T. Juang, A. Weinstein, and G. C. Tsokos, "CAMP response element modulator α expression in patients ... T. Rauen, K. Benedyk, Y.-T. Juang et al., "A novel intronic cAMP response element modulator (CREM) promoter is regulated by ...
Table of Contents - November 01, 2005, 175 (9) | The Journal of Immunology
The Cyclic AMP Response Element Modulator Regulates Transcription of the TCR ζ-Chain Klaus Tenbrock, Vasileios C. Kyttaris, ... Osteopontin Is Not Required for the Development of Th1 Responses and Viral Immunity Brian Abel, Stefan Freigang, Martin F. ... Distinct Regulation of H2-M3-Restricted Memory T Cell Responses in Lymph Node and Spleen Alexander Ploss, Ingrid Leiner and ... Cutting Edge: Early IFN-γ Signaling Directly Enhances Primary Antiviral CD4+ T Cell Responses Jason K. Whitmire, Nicola Benning ...
CAMP responsive element modulator - Wikipedia
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
Frontiers | Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal...
2012). Cyclic AMP response element modulator-1 (CREM-1) involves in Neuronal Apoptosis after Traumatic brain injury. J. Mol. ... Zick, Y., Eisenstein, M., Goren, R. A., Hadari, Y. R., Levy, Y., and Ronen, D. (2004). Role of galectin-8 as a modulator of ... The phase contrast images in the panel illustrate the response of PC12 cells on PLL after applying a hyperosmotic shock (15 min ... We were able to dissect potential nanotopography-sensitive key elements regulated within a mechanotransductive sequence, ...
TAF4 - Wikipedia
Frontiers | Sex Hormones in Acquired Immunity and Autoimmune Disease | Immunology
Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ... This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health and ...
Memory Deficits and Transcription Factor Activity Following Traumatic Brain Injury | IntechOpen
124 - Wu, X., et al., Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain ... early growth response (Egr) factor protein, nuclear factor kappa B (NF-κB) protein, and cAMP response element-binding (CREB) ... 43 - Cernak, I., et al., Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma ... 125 - Sandhir, R. and N.E. Berman, Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury ...
IJMS | Free Full-Text | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females | HTML
Moulton, V.R.; Holcomb, D.R.; Zajdel, M.C.; Tsokos, G.C. Estrogen upregulates cyclic AMP response element modulator alpha ... In vitro-activated human lupus T cells express normal estrogen receptor proteins which bind to the estrogen response element. ... Yeh, Y.C.; Yen, H.R.; Jiang, R.S.; Wang, R.C.; Huang, W.C.; Chen, S.C.; Lin, B.S.; Liang, K.L. Dose-response relationship of ... Sex Hormone Influences on the Induction of CD4+ T Cell-Mediated Immune Responses. CD4+ T helper (Th) cells are the major T cell ...
Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. - PubMed - NCBI
... of downstream targets including dopamine and cyclic-AMP regulated phosphoprotein of 32 kDa and cyclic-AMP-response element ... Ivermectin, an allosteric modulator of P2X4Rs, significantly affected dopamine and cyclic AMP regulated phosphoprotein of 32 ... Ivermectin (IVM), a positive modulator of P2X4Rs, enhanced levodopa (L-DOPA)-induced motor behavior. These studies highlight ...
Staff Profile - Faculty of Medical Sciences - Newcastle University
The switch in alternative splicing of cyclic AMP-response element modulator protein CREMτ2α (activator) to CREMα (repressor) in ... Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2 ... The role of cAMP-response element binding (CREB) and modulator (CREMα and CREMτ2α) proteins. Journal of Molecular Endocrinology ... Can cobalt from metal-on-metal joints activate human TLR4 and cause an inflammatory response?. Bone and Joint Journal 2014, 96- ...
Botanicals as Modulators of Neuroplasticity: Focus on BDNF
Y. Xu, C. Cui, C. Pang, Y. Christen, and Y. Luo, "Restoration of impaired phosphorylation of cyclic AMP response element- ... age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding ... Botanicals as Modulators of Neuroplasticity: Focus on BDNF. Enrico Sangiovanni, Paola Brivio, Mario DellAgli, and Francesca ... D. Miyazawa, Y. Yasui, K. Yamada, N. Ohara, and H. Okuyama, "Regional differences of the mouse brain in response to an α- ...
Testicular Signaling: Team Work in Sperm Production | Springer for Research & Development
cAMP-response element. CREB. Cyclic AMP-responsive element-binding protein 1. CREM. cAMP-responsive element modulators ... Scobey MJ, Bertera S, Somers JP et al (2001) Delivery of a cyclic adenosine 3′,5′-monophosphate response element-binding ... Kangasniemi M, Kaipia A, Mali P et al (1990) Modulation of basal and FSH-dependent cyclic AMP production in rat seminiferous ... Fix C, Jordan C, Cano P, Walker WH (2004) Testosterone activates mitogen-activated protein kinase and the cAMP response element ...
Investigation of Polymorphisms in the CREM Gene in Panic Disorder<...
Cyclic AMP Response Element Modulator * Panic Disorder * Genes * Haplotypes * Single Nucleotide Polymorphism ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ... 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. ...
KEGG BRITE: KEGG Orthology (KO) - Ailuropoda melanoleuca (giant panda)
... cyclic AMP-dependent transcription factor ATF-6 beta K09052 CREM; cAMP response element modulator K09053 ATF1; activating ... 100477711 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 100465448 CREB3L3; cyclic AMP-responsive element- ... 100472104 CREB3; cyclic AMP-responsive element-binding protein 3 100470867 CREB3L1; cyclic AMP-responsive element-binding ... cyclic AMP-responsive element-binding protein 1 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ...
WikiGenes - Response Elements
No maternal behavior phenotype was present in mice with a null mutation of the cyclic AMP response element modulator (Crem) ... The cyclic AMP response element (CRE) is found in many cellular genes regulated by cyclic AMP, and similar elements are present ... A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in ... Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior. Jin, S.H., Blendy, J.A., Thomas ...
KEGG BRITE: KEGG Orthology (KO) - Homo sapiens (human)
... cyclic AMP-dependent transcription factor ATF-6 beta K09052 CREM; cAMP response element modulator K09053 ATF1; activating ... cyclic AMP-responsive element-binding protein 1 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ... cyclic AMP-responsive element-binding protein 3 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09048 CREB3; ... cyclic AMP-responsive element-binding protein 3 K09048 CREB3; cyclic AMP-responsive element-binding protein 3 K09049 ATF6B; ...
Protocols and Video Articles Authored by Ronglih Liao (Translated to Russian)
Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... cyclic AMP-response element binding protein (CREB)-mediated G6PD transcription. In vivo, infusion of aldosterone decreased ... In response to the alpha-adrenergic agonist phenylephrine, they show marked attenuation in the hypertrophic response compared ... Parasympathetic Response in Chick Myocytes and Mouse Heart is Controlled by SREBP The Journal of Clinical Investigation. Jan, ...
Plus it
... the cyclic AMP (cAMP) response element (CRE)-binding protein (CREB) family, which includes ATF1, CREB1, and the cAMP response ... element modulator (CREM; ref. 24). Both ATF1 ( 25) and CREB1 ( 26) are expressed ubiquitously, whereas CREM ( 27) is highly ... Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 1988; 242: 1430-3. ... Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human ...
WikiGenes - G6PD - glucose-6-phosphate dehydrogenase
Aldosterone decreased G6PD expression by increasing expression of the cyclic AMP-response element modulator (CREM) to inhibit ... Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Wolf, S.F., ... Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis. Wilmanski, J ... To assess the responses of the Alzheimers brain to possible oxidative challenges, we assayed for glutathione, glucose-6- ...
CREMCREBAdenosine monophosphateProteinsGenesTranscriptionPhosphorylationNucleotidePromotersTranscriptionalRegulatesPhosphodiesteraseProtein kinaseExtracellularDopamineInduciblePhysiologicalCAMP-responsive elementPromoter activitySystemic Lupus ErythemReceptorsPathwaysCellularBDNFImmuneExpressionEndogenousSequencesSignaling pathwayMetabolismInhibitionDiseasesRegulatoryEnzymesInhibitorInflammatoryDifferencesDifferential
CREM20
- 2003: Am J Med Genet 117B:70-78] suggest that the cAMP responsive element modulator (CREM) may be involved in panic disorder. (curehunter.com)
- We previously showed that the expression of the transcriptional repressor cyclic AMP response element modulator α (CREMα) is increased in SLE T cells and contributes to reduced IL-2 production. (springer.com)
- The IL-2 promoter defines a consensus CRE site at position -180, which can bind the cyclic AMP response element binding (CREB) and cyclic AMP response element modulator (CREM) transcription factors. (springer.com)
- The transcription factor cAMP-response element modulator (CREM) protein, plays a major role in cAMP-responsive gene regulation. (cshl.edu)
- Furthermore we have recently reported that this change in the expression of CREM spliced variants is likely to have important ramifications on the regulation of downstream cAMP-response element-responsive target genes involved in uterine activity during gestation. (cshl.edu)
- Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. (nih.gov)
- The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to increased IL-17 expression in patients with autoimmune disorders. (bmj.com)
- Unexpectedly, our study indicates that CREMα transgenic T cells shift chronic inflammation in Nemo Δhepa livers towards a protective Treg response. (bmj.com)
- Mice overexpressing cyclic AMP-responsive element modulator α (CREMα) in T cells are characterised by enhanced production of interleukin 17 (IL-17), IL-21 and IL-22 as well as retinoid receptor-related orphan receptor gamma-t (RORγT), and have increased inflammatory response. (bmj.com)
- Cyclic adenosine monophosphate response element modulator (CREM) and TRF2, key transcription factors for spermiogenesis, are expressed in Tdrd5 -deficient round spermatids, but their targets, including Prm1 / Prm2 / Tnp1 , are severely down-regulated, which indicates the importance of IMC/CB-mediated regulation for postmeiotic gene expression. (rupress.org)
- A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus," Journal of Biological Chemistry , vol. 286, no. 37, pp. 32366-32372, 2011. (hindawi.com)
- C. M. Hedrich, T. Rauen, and G. C. Tsokos, "cAMP-responsive element modulator (CREM) α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus," The Journal of Biological Chemistry , vol. 286, no. 50, pp. 43429-43436, 2011. (hindawi.com)
- cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. (wikipedia.org)
- The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009) CAMP responsive element modulator has been shown to interact with FHL5. (wikipedia.org)
- The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes. (wikipedia.org)
- Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. (beds.ac.uk)
- Three transcription factors, including cAMP response element-binding protein (CREB), cAMP response element modulator (CREM), and activating transcription factor 1 (ATF1), can be phosphorylated by PKA and subsequently bind to cAMP response elements (CRE) in gene promoters, generally to activate gene transcription ( Sands and Palmer, 2008 ). (elifesciences.org)
- Transcriptional responses to increased cAMP occur through activation of the cAMP response element-binding protein (CREB), cAMP response element modulator (CREM), and activating transcription factor 1 (ATF1) ( 9 ). (sciencemag.org)
- To investigate whether the cyclic AMP-responsive element modulator α (CREMα) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. (cdc.gov)
- 9 CAMP Responsive Element Modulator (CREM) Kits ELISA de 4 fabricants sont disponibles sur www.anticorps-enligne.fr. (anticorps-enligne.fr)
CREB5
- The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. (biomedsearch.com)
- CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. (wikipedia.org)
- Transcription factor cyclic AMP response element-binding protein (CREB) in embryonic cortical neurons is an important modulator of Brain-derived neurotrophic factor (BDNF) induced gene expression. (bvsalud.org)
- The PKA signaling pathway plays an important role in protein secretion through the activation of cAMP, in fluid secretion through the elevation of intracellular calcium and in the activation of cAMP response element-binding protein (CREB), which is involved in these signaling cascades. (elsevier.com)
- Here, we identify acetyl-lysine competitive inhibitors targeting the bromodomains of coactivators CREB (cyclic-AMP response element binding protein) binding protein (CBP) and E1A binding protein of 300 kDa (EP300) as potent enhancers of reprogramming. (nature.com)
Adenosine monophosphate3
- Signaling through the cyclic adenosine monophosphate-dependent protein kinase [protein kinase A (PKA)] is an important and widely studied area of signal transduction research. (sciencemag.org)
- The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in numerous processes and is widely regarded as the "classical" second messenger signaling pathway. (sciencemag.org)
- Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. (drugbank.ca)
Proteins3
- cAMP is synthesized from adenosine triphosphate (ATP) by adenylyl cyclase and is broken down to 5′ AMP by a class of proteins known as phosphodiesterases (PDEs) ( 1 , 2 ). (sciencemag.org)
- DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE) which results in the activation of genes . (bionity.com)
- c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes. (childrensmercy.org)
Genes3
- The potentially relevant genes that were elevated (15% to 28%) were P protein, LCK, cAMP responsive element modulator, IL-7 receptor, matrix metalloproteinase-19, M130 antigen, and peptidyl-prolyl isomerase. (nih.gov)
- Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). (nih.gov)
- All primers pairs of the tested genes showed Inhibitors,Modulators,Libraries a similar amplification efficiency to the one used for the ACTIN gene which was used as reference. (inhibitorlibraries.com)
Transcription7
- Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. (curehunter.com)
- The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain," Journal of Immunology , vol. 175, no. 9, pp. 5975-5980, 2005. (hindawi.com)
- This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. (wikipedia.org)
- Besides the CRE elements, each TRE sequence includes an E box as a target sequence for the AP4 transcription factor. (biomedcentral.com)
- AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). (drugbank.ca)
- They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN. (uchicago.edu)
- Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. (uniprot.org)
Phosphorylation3
- post-synaptic markers including dopamine receptors and phosphorylation of downstream targets including dopamine and cyclic-AMP regulated phosphoprotein of 32 kDa and cyclic-AMP-response element binding protein in different parts of the striatum. (nih.gov)
- Ivermectin, an allosteric modulator of P2X4Rs, significantly affected dopamine and cyclic AMP regulated phosphoprotein of 32 kDa and extracellular regulated kinase1/2 phosphorylation in the striatum. (nih.gov)
- Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. (drugbank.ca)
Nucleotide4
- Principally, cAMP exerts its function through three major targets − cAMP-dependent protein kinase A (PKA), cyclic nucleotide-gated ion channels (CNGCs), and exchange protein directly activated by cAMP (Epac). (elifesciences.org)
- cAMP has three direct intracellular targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). (sciencemag.org)
- CNGCs, nonselective cation channels that open upon cyclic nucleotide binding, are particularly important in the olfactory and visual systems ( 3 ). (sciencemag.org)
- Studies have shown that mice fed a nucleotide-free diet have both impaired humoral and cellular immune responses. (drugbank.ca)
Promoters2
- This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). (beds.ac.uk)
- Dioxin is thought to exert its biological and toxicological effects primarily by binding to the aryl hydrocarbon receptor (AhR, dioxin receptor) followed by nuclear translocation and binding to dioxin-responsive elements (DREs) in gene promoters (reviewed by Beischlag et al. (thefreelibrary.com)
Transcriptional1
- Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus," The Journal of Biological Chemistry , vol. 286, no. 3, pp. 1795-1801, 2011. (hindawi.com)
Regulates1
- FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. (umassmed.edu)
Phosphodiesterase1
- The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. (bionity.com)
Protein kinase2
- 25-Dihydroxyvitamin D3 injection also abolished the effects of exercise on the consummate end-products of brain-derived neurotrophic factor action, i.e. cyclic AMP response element-binding protein and synapsin I, and modulated phosphorylated calmodulin protein kinase II, a signal transduction cascade downstream to brain-derived neurotrophic factor action that is important for learning and memory. (unboundmedicine.com)
- Cyclic AMP-dependent protein kinases ( protein kinase A ) are activated by the signal chain coming from the G protein (that was activated by the LHCG-receptor) via adenylate cyclase and cyclic AMP (cAMP). (bionity.com)
Extracellular2
- The transduction of extracellular signals to intracellular responses is one of the most important and complicated aspects of cellular life. (sciencemag.org)
- The presence of intracellular kinase inhibitor Belinostat Ca2 is required for E2 mediated dopamine efflux Although we have controlled for dopamine flux specifi cally through the DAT through the use of DAT and nore pinephrine selective transporter inhibitors, the addition of these inhibitors does not account for the possibility of exocytotic release of dopamine which is dependent on extracellular Inhibitors,Modulators,Libraries Ca2. (inhibitorlibraries.com)
Dopamine2
- However, the prior emptying Inhibitors,Modulators,Libraries of intracel lular stores of Ca2 with thapsigargin did reverse E2 medi ated dopamine efflux. (inhibitorlibraries.com)
- Vesicular Inhibitors,Modulators,Libraries release of dopamine is not involved in E2 mediated dopamine efflux We then further examined the mechanisms involved in the E2 induced movement of dopamine to the outside of PC12 cells. (inhibitorlibraries.com)
Inducible1
- Finally, we found that PGE2 stimulated the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs, thus providing mechanistic insight into how PGE2 signaling down-modulates RALDH. (ox.ac.uk)
Physiological1
- adenosine is an important endogenous physiological modulator of heart function. (physiology.org)
CAMP-responsive element1
- Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. (biomedsearch.com)
Promoter activity1
- We investigated the effects of mutating these -170 CRE and -150 CCAAT elements on the promoter activity regulated by three different modulators previously known to act through CRE: ATF-2, cAMP and E1a. (sussex.ac.uk)
Systemic Lupus Erythem1
- This review focuses on the role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus. (frontiersin.org)
Receptors2
- The production of retinoic acid (RA) by dendritic cells (DCs) is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors, such as α4β7 and CCR9, upon T and B cell activation. (ox.ac.uk)
- Cyclic AMP (cAMP), the second messenger, converts the binding of ligands with many different G-protein coupled receptors (GPCRs, also known as seven-transmembrane domain receptors) into various biological activities ( Sutherland, 1970 ). (elifesciences.org)
Pathways4
- Clinical and animal studies suggest a role for pathways regulated by cyclic-AMP in anxiety. (elsevier.com)
- Although the different levels of dietary fish and vegetable oils involved in this study affected the expression of some transcripts, the immune-related pathways and functions activated by the antiviral response of salmon MLCs in both groups were comparable overall. (biomedcentral.com)
- RLR-, TLR-, MAPK- and IFN-associated pathways) activated by the antiviral response of salmon MLCs. (biomedcentral.com)
- Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. (umassmed.edu)
Cellular1
- Abnormal T cells orchestrate responses of multiple cellular components of the immune system either directly or through secretion of cytokines. (springer.com)
BDNF2
- The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. (hindawi.com)
- The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. (hindawi.com)
Immune15
- Women have stronger immune responses to infections and vaccination than men. (frontiersin.org)
- Paradoxically, the stronger immune response comes at a steep price, which is the high incidence of autoimmune diseases in women. (frontiersin.org)
- Besides gender, sex hormones contribute to the development and activity of the immune system, accounting for differences in gender-related immune responses. (frontiersin.org)
- Intriguingly, the same immune response shifts during pregnancy to "tolerate" the foreign fetus and prevent rejection. (frontiersin.org)
- There is evidence that there are differences in the immune response in the male seahorse during the parental vs. mating phases with improved immunity during the parental stage ( 1 , 2 ). (frontiersin.org)
- A "side-effect" of the stronger immune response is the higher propensity for developing autoimmune disease. (frontiersin.org)
- Sex hormones not only control the reproductive system, but also regulate the development, and function of the immune response. (frontiersin.org)
- Innate and adaptive, humoral and cell-mediated immune responses are impacted by hormones, and dysregulation of these mechanisms contribute to immune-mediated diseases including autoimmune disease ( 3 - 9 ). (frontiersin.org)
- It has been known for some time that sex hormones influence the function and activity of the immune system and likely contribute to the sex-based differences in immune-mediated disease responses. (mdpi.com)
- In general, these effects have resulted in adult females inducing a more efficient humoral-based immune response upon pathogen challenge, whereas males tend to mount a less efficient immune response [ 1 , 2 ]. (mdpi.com)
- Given the role of PGE2 in regulating the development of RA-producing DCs, modulating this pathway may prove a novel means to control the development of gut-tropic immune responses. (ox.ac.uk)
- A heterodimeric cytokine that plays a role in innate and adaptive immune responses. (harvard.edu)
- Fatty acids, notably polyunsaturated fatty acids (PUFAs), play an important role in innate immune responses and the functions of immune cells (e.g. (biomedcentral.com)
- AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. (drugbank.ca)
- Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvation-induced immunosuppression, the enhancement of T-cell maturation and function, the enhancement of natural killer cell activity, the improvement of delayed cutaneous hypersensitivity, helping resistance to such infectious agents as Staphylococcus aureus and Candida albicans, and finally the modulation of T-cell responses toward type 1 CD4 helper lymphocytes or Th1 cells. (drugbank.ca)
Expression4
- These findings underscore the importance of PTHrP in response to growth plate irradiation and show the novel finding of a decrease in Bax expression with amifostine pretreatment. (labome.org)
- Furthermore, the maturation of clock function seems to correlate with the appearance of rhythmic expression of these positive elements of the clock feedback loop. (uni-heidelberg.de)
- The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1. (freepatentsonline.com)
- 20. The expression system of claim 1, wherein the neuron-specific regulatory element is the synapsin promoter as set forth in FIG. 8 beginning at position 7 and ending at position 488. (freepatentsonline.com)
Endogenous1
- A tumor-specific endogenous repetitive element is induced by herpesviruses. (harvard.edu)
Sequences1
- Twelve unique SNPs for these LTR sequences localized in regulatory and non-regulatory elements were identified. (biomedcentral.com)
Signaling pathway1
- AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. (drugbank.ca)
Metabolism2
- We infused 1,25-dihydroxyvitamin D3, a modulator of energy metabolism, directly into the hippocampus during 3 days of voluntary wheel running and measured its effects on brain-derived neurotrophic factor-mediated synaptic plasticity. (unboundmedicine.com)
- Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity. (unboundmedicine.com)
Inhibition1
- but dependent on inhibition of serum response element (SRE) activity. (ecologicalsgardens.com)
Diseases1
- Aims Cyclic AMP inhibits vascular clean muscle cell (VSMC) proliferation which is important in the aetiology of numerous vascular diseases. (ecologicalsgardens.com)
Regulatory1
- We and others have shown that SLE T cells display decreased capacity to produce IL-2, a cytokine crucial to the development of cytotoxic responses, regulatory T-cell function and activation-induced cell death (13). (springer.com)
Enzymes1
- Chromatin-modifying enzymes as modulators of reprogramming. (nature.com)
Inhibitor1
- CCPA reduced this response by 47%, an action inhibited by the PLC inhibitor U-73122 and 8-cyclopentyl-1,3-dipropylxanthine. (physiology.org)
Inflammatory1
- LPLI also suppresses the inflammatory response of LPS-induced inflammation of stem cells. (ncku.edu.tw)
Differences1
- These data provide additional evidence that oligodendrogenesis is differentially regulated in white matter and gray matter and implicate PLP/DM20 as a modulator of these differences. (labome.org)
Differential1
- Thus, differential maturation of key elements of the medaka clock mechanism depends on the developmental stage and the presence of the chorion. (uni-heidelberg.de)