Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes. (1/246)

Previously, we have shown that nuclear extracts from cultured mouse keratinocytes induced to differentiate by increasing the levels of extra-cellular calcium contain Fra-1, Fra-2, Jun B, Jun D and c-Jun proteins that bind to the AP-1 DNA binding sequence. Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells. Here, we have detected the CREB family proteins CREB and CREMalpha as additional participants in the AP-1 DNA binding complex in differentiating keratinocytes. AP-1 and CRE DNA binding activity correlated with the induction of CREB, CREMalpha and ATF-1 and CREB phosphorylation at ser133 (ser133 phospho-CREB) in the transition from basal to differentiating keratinocytes, but the activity of a CRE reporter remained unchanged. In contrast, the CRE reporter was activated in the presence of the dominant-negative (DN) CREB mutants, KCREB and A-CREB, proteins that dimerize with CREB family members and block their ability to bind to DNA. The increase in CRE reporter activity in the presence of these mutants suggests that CRE-mediated transcriptional activity is suppressed in keratinocytes through protein-protein interactions involving a factor that dimerizes with the CREB leucine zipper. In experiments where the A-CREB mutant was co-transfected with an AP-1 reporter construct, transcriptional activity was also increased indicating that a CREB family member binds AP-1 sites and represses AP-1 transcriptional activity as well. Exogenous expression of the transcriptional repressor CREMalpha down-regulated both CRE and AP-1 reporters in keratinocytes suggesting that this factor may contribute to the suppression of AP-1 transcriptional activity observed in differentiating keratinocytes.  (+info)

Regulation of cAMP responsive element binding modulator isoforms in cultured rat ovarian granulosa cells. (2/246)

A pituitary glycoprotein hormone FSH stimulates ovarian granulosa cells to induce ovarian follicular development. In this study we identified rat ovarian genes that were rapidly induced by FSH in the cultured rat granulosa cells by means of subtraction cloning. Complementary DNA clones encoding cAMP responsive element binding modulator (CREM) were identified as one of the FSH inducible genes. Northern blotting and reverse transcription and polymerase chain reaction (RT-PCR) analyses revealed that only the repressor type of CREM gene products, ICER (inducible cAMP early repressor) isoforms, were induced by FSH treatment in cultured rat granulosa cells. The induction of ICER by FSH was mimicked by reagents known to increase intracellular cAMP levels, indicating that the induction is through cAMP and protein kinase A signal transduction system. Induction of ICER was also confirmed as the protein levels. Electrophoretic mobility shift assay of granulosa cell extracts with a radiolabeled double stranded oligonucleotide corresponding to somatostatin cAMP responsive element also revealed that only the ICER proteins were induced by FSH treatment, whereas levels of CREM proteins were nearly constant regardless of the FSH treatment. Our present study demonstrates that FSH-induced and cAMP-mediated induction and attenuation of transcriptional responses by CREM gene products may be a key mechanistic component for the granulosa cell differentiation and proliferation.  (+info)

Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. (3/246)

Neurotransmitter-driven activation of transcription factors is important for control of neuronal and neuroendocrine functions. We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). pCREB accumulates endogenously at the beginning of the dark period and declines during the second half of the night. Concomitant with this decline, the amount of ICER rises. The changing ratio between pCREB and ICER shapes the in vivo dynamics in mRNA and, thus, protein levels of arylalkylamine-N-acetyltransferase, the rate-limiting enzyme of melatonin synthesis. Consequently, a silenced ICER expression in pinealocytes leads to a disinhibited arylalkylamine-N-acetyltransferase transcription and a primarily enhanced melatonin synthesis.  (+info)

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (4/246)

Ubiquitin-mediated proteolysis controls diverse physiological processes in eukaryotes. However, few in vivo targets of the mammalian Cdc34 and Rad6 ubiquitin-conjugating enzymes are known. A yeast-based genetic assay to identify proteins that interact with human Cdc34 resulted in three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog. Transfection assays with mammalian cells demonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIgamma and hATF5. This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription. Consistent with these results, the endogenous ICER protein is elevated in cells which are null for murine Rad6B (mHR6B-/-) or transfected with dominant negative and antisense constructs of human CDC34. Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development. Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regulated manner, with distinctly different patterns for Cdc34 and the Cullin proteins in germ cells. The Cdc34 and Rad6B proteins are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modifications occur. Thus, the stability of specific mammalian transcription factors is the result of complex targeting by multiple ubiquitin-conjugating enzymes and may have an impact on cAMP-inducible gene regulation during both meiotic and mitotic cell cycles.  (+info)

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (5/246)

The p38/stress-activated protein kinase2 (p38/SAPK2) is activated by cellular stress and proinflammatory cytokines. Several transcription factors have been reported to be regulated by p38/SAPK2, and this kinase is involved in the control of expression of various genes. In human Jurkat T-cells, induction of the early growth response gene-1 (egr-1) by anisomycin is completely inhibited by SB203580, a specific inhibitor of p38/SAPK2a and -b. Northern blot and reporter gene experiments indicate that this block is at the level of mRNA biosynthesis. Using mutants of the egr-1 promoter, we demonstrate that a distal cAMP-responsive element (CRE; nucleotides -134 to -126) is necessary to control egr-1 induction by p38/SAPK2. Pull-down assays indicate that phospho-CRE binding protein (CREB) and phospho-activating transcription factor-1 (ATF1) bind to this element in a p38/SAPK2-dependent manner. In response to anisomycin, two known CREB kinases downstream to p38/SAPK2, MAPKAP kinase 2 (MK2) and mitogen- and stress-activated kinase 1 (MSK1), show increased activity. However, in MK2 -/- fibroblasts derived from mice carrying a disruption of the MK2 gene, the phosphorylation of CREB and ATF1 and the expression of egr-1 reach levels comparable with wild type cells. This finding excludes MK2 as an involved enzyme. We conclude that egr-1 induction by anisomycin is mediated by p38/SAPK2 and probably by MSK1. Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene.  (+info)

The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. (6/246)

We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs). We isolated two novel CREM isoforms (CREMDeltaQ1 and CREMDeltaQ2), which lack one of the glutamine-rich domains, Q1 and Q2 respectively, and six known isoforms (CREMtaualpha, CREMalpha, inducible cyclic AMP early repressor (ICER) I, ICER Igamma, CREM-17X, and CREM-17) from rat pancreatic islets and the RINm5F pancreatic beta-cell line. CREM isoforms functioned as efficient transcriptional activators or repressors to modulate insulin promoter activity by binding to all of the insulin CREs. The binding activity of repressors is higher than that of activators and suppressed not only basal activity but also activator-induced activities. Furthermore, CREM activator interacted directly with the transcription factor IID components hTAF(II)130 and TATA box-binding protein (TBP). These results suggest that the activation of the insulin gene transcription by CREM activator is mediated by not only direct binding to the CREs but also by recruiting transcription factor IID to the insulin promoter via its interaction with hTAF(II)130 and TBP. On the other hand, the CREM repressor ICER competitively interrupts the binding of the activators to CREs and does not interact with either TBP or hTAF(II)130; therefore, it might fail to stabilize the basal transcriptional machinery and repress transactivation.  (+info)

A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids. (7/246)

During murine spermatogenesis, beginning in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site. We had shown previously that a 796-bp genomic fragment that flanks the germ cell start site and contains two putative CRE (cyclic AMP-responsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase reporter gene in late pachytene spermatocytes and round spermatids of transgenic mice (N. L. Shaper, A. Harduin-Lepers, and J. H. Shaper, J. Biol. Chem. 269:25165-25171, 1994). We now report that in vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously undescribed 14-bp regulatory element (5'-GCCGGTTTCCTAGA-3') that is distinct from the two CRE-like sequences. This cis element is located 16 bp upstream of the germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (transcriptional activator in late pachytene spermatocytes and round spermatids 1). The presence of the Ets signature binding motif 5'-GGAA-3' on the bottom strand of the TASS-1 sequence (underlined sequence) suggests that TASS-1 is a novel member of the Ets family of transcription factors. Additional transgenic analyses established that an 87-bp genomic fragment containing the TASS-1 regulatory element was sufficient for correct germ cell-specific expression of the beta-galactosidase reporter gene. Furthermore, when the TASS-1 motif was mutated by transversion, within the context of the original 796-bp fragment, transgene expression was reduced 12- to 35-fold in vivo.  (+info)

Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. (8/246)

Rhythmic activity of arylalkylamine N-acetyltransferase (AANAT) determines melatonin synthesis in rat pineal gland. The transcriptional regulation of AANAT involves the activating and inhibiting transcription factors of the cyclic AMP (cAMP)-signaling pathway, cAMP response element-binding protein and inducible cAMP early repressor (ICER), respectively. Activation of this pathway is centered around norepinephrine, stimulating beta(1)-adrenergic receptors, but various other transmitters can modulate melatonin biosynthesis. To compare the transcriptional impact of norepinephrine with that of other neurotransmitters on melatonin synthesis, we determined ICER protein levels in pinealocytes and, in parallel, hormone secretion. The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production. Importantly, ICER protein induction required lower ligand concentrations than the induction of melatonin biosynthesis. Although neuropeptide Y, glutamate, and vasopressin altered norepinephrine-stimulated hormone production without affecting ICER levels, the activation of voltage-gated cation channels increased ICER without affecting hormone synthesis. Sensitivity and versatility of ICER induction in pinealocytes make these neuroendocrine cells a valuable model system in which to study molecular interactions determining a regulated gene expression.  (+info)

Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". ...
"The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188-99. doi: ...
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP- ... Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ...
Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ...
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... Poo, M.M. (2001). Neurotrophins as synaptic modulators. Nat Rev Neurosci, 2, 24-32 102. Yan, Q.S., Feng, M.J., Yan, S.E. (2005 ... Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ...
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many ... The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'- ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ...
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Small-molecule positive allosteric modulators of the FSHR have been developed. Alfred G. Gilman and Martin Rodbell received the ... For a cell to respond to FSH, only a small percentage (~1%) of receptor sites need to be activated.[citation needed] Cyclic AMP ... The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. ...
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... Hepatitis A 3C protease cleaves NEMO at the Q304 residue; NEMO is a NF-κB essential modulator responsible for activation of ... interferon (IFN) antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating ...
Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic ... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ... Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW (Feb 2009). "Positive allosteric modulators of the metabotropic ... Beqollari D, Kammermeier PJ (Jul 2008). "The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b] ...
... induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a ... "Structural features of subtype-selective EP receptor modulators". Drug Discovery Today. 22 (1): 57-71. doi:10.1016/j.drudis. ... EP2 also activates the a) GSK-3 pathway which regulates cell migratory responses and innate immune responses including pro- ... A 2021 study found that inhibition of myeloid cell EP2 signalling can reverse or prevent an inflammation element of brain- ...
3). In the nucleus the dimer interacts with progesterone hormone response element in the DNA causing upregulation or ... and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor". Molecular and Cellular Biology. ... Phytoprogestogen Selective androgen receptor modulator Selective estrogen receptor modulator Selective glucocorticoid receptor ... Progesterone receptor modulators with unique nonsteroidal structures are currently in the early stages of development (Fig. 5- ...
... growth hormone response element) IGF-1 and IGFBP-3 expression Via THR/THRE (thyroid hormone response element) Angiotensinogen ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... "The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration". Annals of the New York Academy of ... Then, it converts adenosine triphosphate into cyclic AMP, which activates Protein kinase A. PKA leads to protein tyrosine ...
Manganiello V, Evans WH, Stossel TP, Mason RJ, Vaughan M. The effect of polystyrene beads on cyclic AMP concentration in human ... Mechanical responses of white blood cells. In: Inflammation. Basic Mechanism and Clinical Correlates. J. Gallin, I. Goldstein, ... In: Cytoskeletal Elements and Plasma Membrane Organization, Poste G, Nicolson GL, eds, Elsevier, Amsterdam, 1981; 140-168. 41. ... pGSN is a master regulator-a key immune modulator that balances the inflammatory process to prevent the spread of excess ...
CREB (cAMP response element binding protein) belongs to a family of transcription factors and is positioned in the nucleus of ... Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS (October 2015). "Mechanisms of cyclic AMP/protein ... which has been shown to be a cellular growth factor modulator with met-enkephalin being the endogenous ligand. This receptor is ... The CREB protein binds to cAMP response elements CRE, and can either increase or decrease the transcription of certain genes. ...
Cyclic AMP-response element modulator inhibits the promoter activity of the sodium iodide symporter gene in thyroid cancer ...
Cyclic AMP Response Element-Binding Protein A [D12.776.260.108.186] * Cyclic AMP Response Element Modulator [D12.776.260.108. ... Cyclic AMP Response Element-Binding Protein A [D12.776.930.127.186] * Cyclic AMP Response Element Modulator [D12.776.930.127. ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ...
... cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP ... Cyclic AMP Response Element-Binding Protein/chemistry; Cyclic AMP Response Element-Binding Protein/metabolism*; DNA Damage*; ... in response to DNA damage through the coordinated actions of the ataxia-telangiectasia-mutated (ATM) protein kinase and casein ...
Cyclic AMP Response Element-Binding Protein A [D12.776.260.108.186] * Cyclic AMP Response Element Modulator [D12.776.260.108. ... Cyclic AMP Response Element-Binding Protein A [D12.776.930.127.186] * Cyclic AMP Response Element Modulator [D12.776.930.127. ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ...
Cyclic AMP Response Element Modulator - Preferred Concept UI. M0185189. Scope note. Cyclic AMP response element modulator is a ... Cyclic AMP Response Element Modulator Entry term(s). Inducible cAMP Early Regulator cAMP Responsive Element Modulator cAMP- ... Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays ... Cyclic AMP Response Element Modulator Descriptor Spanish: Modulador del Elemento de Respuesta al AMP Cíclico Spanish from Spain ...
Cyclic AMP Response Element Modulator N0000169862 Cyclic AMP Response Element-Binding Protein N0000169868 Cyclic AMP Response ... Cyclic AMP-Dependent Protein Kinase Type I N0000178580 Cyclic AMP-Dependent Protein Kinase Type II N0000170598 Cyclic AMP- ... Cyclic N0000170820 8-Bromo Cyclic Adenosine Monophosphate N0000168976 Receptors, Cyclic AMP N0000170851 Dibutyryl Cyclic GMP ... Element-Binding Protein A N0000178795 Cyclic AMP-Dependent Protein Kinase Catalytic Subunits N0000178690 Cyclic AMP-Dependent ...
Cyclic AMP Response Element Modulator. *Calcium-Calmodulin-Dependent Protein Kinase Type 4 ...
ICERIgamma use Cyclic AMP Response Element Modulator ICERIIgamma use Cyclic AMP Response Element Modulator ... I(h) Cation Channels use Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels I(h) Channels use Hyperpolarization- ...
037044 48.17 cyclic AMP-dependent transcription factor ATF-3 Atf3 Rattus norvegicus " In solution, it binds the cAMP response ... Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and ... May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response ... Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Also ...
Cyclic AMP:metabolism, Cyclic AMP Response Element Modulator:metabolism, Dopamine Agonists:pharmacology, Dopamine Antagonists: ...
Cyclic AMP Response Element Modulator UI - D051786 MN - D12.776.260.108.217 MN - D12.776.930.127.217 MS - Cyclic AMP response ... HN - 2006(1991) BX - cAMP-Responsive Element Modulator MH - Cyclic AMP Response Element-Binding Protein A UI - D051699 MN - ... factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP- ... of the cyclic AMP response element in partnership with either PROTO-ONCOGENE PROTEINS C-JUN or activating transcription factor ...
The expression of phosphorylated cyclic-AMP response element binding protein (pCREB) and brain-derived neurotrophic factor ( ... We have reported that the carborane compound BE360 is a novel selective estrogen receptor modulator and new therapy option for ... and phosphate-cyclic adenosine monophosphate response element-binding protein (CREB) in OBX mice. These data indicate that LH ... We also investigated potential effects of SG-ME on several parameters: cell proliferation and cAMP response element-binding ...
We know that morphine affects the phosphorylation state of cyclic AMP response element binding protein (CREB), a critical ... have provided important insights into receptors for neurotransmitters and modulators that play a role in sensory perception, ... Because the nature and scope of the work proposed in response to this RFA may vary, the size and number of the awards will also ... The Division of Research Grants (DRG) will not accept any application in response to this RFA that is essentially the same as ...
CRC cyclic redundancy check CREAM cosmic radiation effects and activation monitors CRTSSDA cascaded reactively terminated ... N-AMPS Narrowband Advanced Mobile Phone System NAVSTAR Navigational Satellite Timing and Ranging system ... CALLUM combined analog locked-loop universal modulator CATV community antenna television CBCPS conductor-backed coplanar ... LEP lumped element prototype LHCP left-hand circular polarization LIDAR light direction and ranging ...
Pandey, S.C. The gene transcription factor cyclic AMP-responsive element binding protein: Role in positive and negative ... Pandey, S.C.; Roy, A.; and Zhang, H. The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element ... Poo, M.M. Neurotrophins as synaptic modulators. Nature Reviews. Neuroscience 2(1):24-32, 2001. PMID: 11253356 ... Pizzorusso, T.; Ratto, G.M.; Putignano, E.; and Maffei, L. Brain-derived neurotrophic factor causes cAMP response element- ...
... their overall intracellular concentration may not reach damaging levels due to enhancement of antioxidant responses. However, ... which may induce a very strong anti-inflammatory cytokine response. The main modulator of these responses is likely the ... their effects mediated through an increase in cyclic AMP.. L-arginine supplementation may improve maximal (VO2max test) ... heat shock elements (HSEs); oxidized GSH (GSSG); GSH-S reductase (GSR); glutamate dehydrogenase (GLUD); alpha-ketoglutarato (α- ...
2006). Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element.FEBS Letters 580, 58- ... We have since discovered that CREB3 and CREBRF are regulators of the glucocorticoid signaling and key modulators of lipid ... 2006) Luman/CREB3 induces transcription of the endoplasmic reticulum stress response protein, Herp, through an ERSE-II element. ... Key words: ER and Golgi stress; Unfolded Protein Response (UPR); glucocorticoid signaling; gene knockout mice; animal stress; ...
Cyclic AMP response element-binding proteins (CREB) is essential for LTP and LTM, however, not for E-LTP or short-term storage ... The balance of phosphorylated and dephosphorylated cofilin is in turn one of the key modulators of actin filament assembly and ... CREB: cAMP response element-binding protein; CTD: C-terminal domain name of Neuroligin-1; LIMK: Lim kinase, shown with dual ... CREB: cAMP response element-binding proteins; CTD: C-terminal domains of Neuroligin-1; LIMK: Lim kinase, proven with dual ...
An example of this is the specific binding of 3,5-cyclic adenosine monophosphate to the cyclic AMP receptor protein, I. Pastan ... that the special nucleotides of this invention act as immune modulators and stimulators of the immune response other than ... A semi-synthetic medium containing salt, 1% glucose, 0.1% asparagine, 0.05% yeast extract and trace elements was prepared. The ... 1. Enzymes and allosteric effector or modulator molecules. An example of this is the enzyme threonine dehydratase which is a ...
STI responses during exercise and recovery have seldom been reported, although limited data suggests that intensity is a key ... Post-exercise, a greater preceding intensity is associated with a slower HRV recovery, although the dose-response remains ... There are substantial methodological disparities throughout the literature regarding HRV responses to exercise, in terms of ... suggests that investigating responses to a stressor (e.g. exercise) may be a valuable monitoring approach in clinical and high- ...
The cAMP analogue 8-pCPT-2OMe-cAMP (8-CPT) that selectively activates the exchange protein activated by cyclic AMP (Epac) was ... The reporter 4xCDRElacZ, containing calcineurin-dependent response elements in its promoter, revealed that calcineurin ... Session 7. Chemical Modulators: Drug Discovery and Pharmacology Chairs: J. Antonio Lamas (U. de Vigo)/ Rosario González-Muñiz ( ... cyclic nucleotide-gated (CNG) channels important in sensory transduction and the hyperpolarization-activated, cyclic nucleotide ...
We also demonstrated that Act increased cyclic AMP (cAMP) production in macrophages. cAMP, along with PGE(2), could potentiate ... Haemato-immunological responses and effectiveness of feed-based bivalent vaccine against Streptococcus iniae and Aeromonas.... ... After Act treatment of RAW cells, we detected an increased translocation of NF-kappaB and cAMP-responsive element binding ... The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.. ...
Inhibition of PPARG and cyclic AMP-responsive element binding protein H (CREBH) prevented the increases in Fsp27α and FSP27β ... In addition, GIRK3 KO mice showed a blunted response of the mesolimbic dopaminergic (DA) pathway to ethanol, as assessed by ... We also validated that Bcl-2 antagonist killer 1 (Bak1) and p53-upregulated modulator of apoptosis (PUMA) are the direct ... Constitutive deletion of the GIRK3 subunit has minimal phenotypic consequences, except in response to drugs of abuse. Here we ...
As the complex Mg-ATP2−, magnesium is essential for all biosynthetic processes, glycolysis, formation of cyclic-AMP, energy- ... Metabolic responses of adolescent boys to two levels of dietary magnesium and protein. I. Magnesium and nitrogen retention. Am ... Cows milk contains both more calcium and phophorus than does human milk, and the ratios of the elements differ widely. The ... and in enzymes as a modulator of their activities. Energy for metabolic processes derives largely from the phosphate bonds of ...
Bastiaens, Multiple frequency fluorescence lifetime imag- ing microscopy, J. Rise in intra- cellular cyclic AMP, which acts as ... Write("b"); Response. BioTechniques 19(2), 240253. [38] N. (App. Diode rectifiers can be of the half-wave type, or they can be ... Modulators Used in Plasmodium spp. Schotteliuss list contains approximately 5000 stem word entries. (Note: dont use a good ... Vip forex trading kenya replace the value of the ISBN element for all rows in the Books table, execute this statement: UPDATE ...
Cyclic AMP Levels in MSN in the D2 Pathway Play a Key Role in the Directionality of Corticostriatal Plasticity. Author: SHANA ... Meningeal Mast Cells: Modulators of Effector T cell Function in a Murine Model of Multiple Sclerosis. Author: Margaret Walker ... The Role of LAT in Granule-mediated Cytotoxicity and Immunological Memory Response of CD8 T cells. Author: Chihwen Ouyang ... The Role of Chromatin in Regulating Genomic Functional Elements. Author: William Lai ...
7. Tissue from the middle slice increased its rate of synthesis of 3,5-cyclic AMP in response to addition of dopamine 20 or 100 ... PMID- 214464 TI - Membrane-bound forms of Ca2+-dependent protein modulator: Ca2+-dependent and independent binding of modulator ... To find out whether this activity is located in bona fide Golgi elements or in contaminating microsomal vesicles, we used the ... micron cyclic AMP or 0.6 micron cyclic GMP was the enzyme substrate. The stimulation of adipocyte cyclic AMP phosphodiesterase ...
... mediated by activation of the cyclic adenosine monophosphate (cAMP)/protein kinase cAMP-dependent (PKA)/adenosine monophosphate ... AMP-activated protein kinase 1 protects against diet-induced insulin resistance and obesity. Diabetes 2013, 62, 998. [Google ... Oleson, B.J.; Corbett, J.A. Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage. Antioxid. Redox ... Kraus, B.; Wolff, H.; Elstner, E.F.; Heilmann, J. Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis ...
  • Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in the regulation of cellular growth, metabolism, and survival. (nih.gov)
  • The use of proteins and amino acids for supplementation deserves special attention, since these molecules are critical for anti-oxidant and fuel provision, participating in the whole-body energy homeostasis, growth, development, recovery and immune responses. (biomedcentral.com)
  • The key targets for immunonutrition may include provision of key metabolites for immune cells per se , the inflammatory response and cytokine release, the production of chaperone proteins such as the heat shock proteins (HSPs), redox balance (including glutathione, GSH metabolism), and protection of skeletal muscle mass (Figure 1 ). (biomedcentral.com)
  • We and others have since produced strong evidence suggesting that these proteins play key roles in cellular stress responses, specifically the Unfolded Protein Response (UPR) triggered primarily by disruption of homeostasis in the endoplasmic reticulum and the Golgi. (uoguelph.ca)
  • 1999). Even though the molecular features of MKRN1 as an ubiquitin ligase of many target protein e.g. hTERT, p53, phosphatase and tensin homolog (PTEN), anaphase-promoting complicated (APC), and AMP-activated proteins kinase (AMPK) have already been well-studied in mammalian cells, but sparse for MKRN3 (Kim et al. (angiogenesis-blog.com)
  • Previous studies demonstrated that CREB is phosphorylated on a cluster of conserved Ser residues, including Ser-111 and Ser-121, in response to DNA damage through the coordinated actions of the ataxia-telangiectasia-mutated (ATM) protein kinase and casein kinases 1 and 2 (CK1/2). (nih.gov)
  • We have since discovered that CREB3 and CREBRF are regulators of the glucocorticoid signaling and key modulators of lipid metabolism. (uoguelph.ca)
  • PMID- 214393 TI - Regulation of growth & metabolism of ovariectomised rat uterus by adenosine 3', 5'-cyclic monophosphate. (nih.gov)
  • PMID- 214392 TI - Regulation of lipogenesis by adenosine 3', 5'-cyclic monophosphate in chicken liver in vitro. (nih.gov)
  • A dose-response analysis showed that there was a non-linear relationship between n-3 PUFA rich seafood intake and the risk of gout in the female group. (bvsalud.org)
  • Post-exercise, a greater preceding intensity is associated with a slower HRV recovery, although the dose-response remains unclear. (frontiersin.org)
  • AKT includes a wide variety of substrates involved in many cellular responses which includes proliferation, apoptosis and development. (mirnainhibitors.com)
  • experimental condition [Term] id: XCO:0000014 name: controlled content diet def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled. (mcw.edu)
  • 19)Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors. (edu.in)
  • 2) What are the genetic variations responsible for the differences among individuals in the response to stresses or susceptibility to metabolic disorders? (uoguelph.ca)
  • There are substantial methodological variations throughout the literature regarding HRV responses to exercise, in terms of exercise protocols and HRV analysis techniques. (frontiersin.org)
  • Biphasic immuno-inflammatory response to severe exercise and the possible immunonutrition role. (biomedcentral.com)
  • Immuno-inflammatory response induced by severe exercise or heavy periods of training and the proposed role of specific nutrients with immune benefits, also called immunonutrition. (biomedcentral.com)
  • In 2001 I took a faculty position here at the University of Guelph and have continued to work on the biological function of Luman/CREB3, Zhangfei/CREBZF and LRF/CREBRF (later discovered in Guelph), and their related stress responses. (uoguelph.ca)
  • We have established CREB3- and CREBRF-gene knockout mouse models, both of which showed strikingly similar phenotype - lean and blunted stress response. (uoguelph.ca)
  • Monitoring HRV responses to an "exercise challenge test" may provide useful insight into autonomic stress reactivity. (frontiersin.org)
  • The focus of this review is on dynamic "aerobic" exercise as this form has received the most attention regarding HRV responses and is commonly used for exercise stress tests. (frontiersin.org)
  • STI responses during exercise and recovery have seldom been reported, although limited data suggests that intensity is a key determining factor. (frontiersin.org)
  • Although exercise training stimulates the production of reactive oxygen species (ROS), their overall intracellular concentration may not reach damaging levels due to enhancement of antioxidant responses. (biomedcentral.com)
  • Although these autonomic indices are typically measured during rest, the "reactivity hypothesis" suggests that investigating responses to a stressor (e.g., exercise) may be a valuable monitoring approach in clinical and high-performance settings. (frontiersin.org)
  • However, when interpreting these indices it is important to consider how the exercise dose itself (i.e., intensity, duration, and modality) may influence the response. (frontiersin.org)
  • To investigate whether the cyclic AMP-responsive element modulator α (CREMα) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. (nih.gov)
  • Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in the regulation of cellular growth, metabolism, and survival. (nih.gov)
  • Because the nature and scope of the work proposed in response to this RFA may vary, the size and number of the awards will also vary. (nih.gov)
  • This suppressive influence could be mediated by ICER (inducible cAMP response early repressor), which is induced by forskolin in both tissues. (nih.gov)
  • Two additional hallmarks have been proposed based on evading immune surveillance[4] and the cancer cell stress response phenotypes. (medscape.com)
  • ADENYLATE CYCLASE, the enzyme that produces cyclic AMP, is part of a complex regulatory system that mediates the actions of hormones and neurotransmitters on their target cells. (nih.gov)