Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Cyclic AMP Response Element Modulator: Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.CREB-Binding Protein: A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.Response Elements: Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.Sterol Regulatory Element Binding Protein 1: A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Activating Transcription Factor 2: An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Activating Transcription Factor 1: An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Activating Transcription Factors: Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Sterol Regulatory Element Binding Protein 2: A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.Cyclic AMP-Dependent Protein Kinases: A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Leucine Zippers: DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.Regulatory Sequences, Nucleic Acid: Nucleic acid sequences involved in regulating the expression of genes.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Sterol Regulatory Element Binding Proteins: Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.Proto-Oncogene Proteins c-fos: Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.CCAAT-Enhancer-Binding Proteins: A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.Gene Products, tax: Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.G-Box Binding Factors: A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.Enhancer Elements, Genetic: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Transcription Factor AP-1: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Proto-Oncogene Proteins c-jun: Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Chloramphenicol O-Acetyltransferase: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Brain-Derived Neurotrophic Factor: A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. (1/16)

In this report, we describe the isolation and initial characterization of a Drosophila protein, dCREB-A, that can bind the somatostatin cyclic AMP (cAMP)-responsive element and is capable of activating transcription in cell culture. Sequence analysis demonstrates that this protein is a member of the leucine zipper family of transcription factors. dCREB-A is unusual in that it contains six hydrophobic residue iterations in the zipper domain rather than the four or five commonly found in this group of proteins. The DNA-binding domain is more closely related to mammalian CREB than to the AP-1 factors in both sequence homology and specificity of cAMP-responsive element binding. In embryos, dCREB-A is expressed in the developing salivary gland. A more complex pattern of expression is detected in the adult; transcripts are found in the brain and optic lobe cell bodies, salivary gland, and midgut epithelial cells of the cardia. In females, dCREB-A is expressed in the ovarian columnar follicle cells, and in males, dCREB-A RNA is seen in the seminal vesicle, ejaculatory duct, and ejaculatory bulb. These results suggest that the dCREB-A transcription factor may be involved in fertility and neurological functions.  (+info)

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (2/16)

We have identified a Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes. DNA sequence analysis of cDNA clones encoding this protein, box B-binding factor-2 (BBF-2), indicates that it is a member of the CREB/ATF family of transcriptional regulatory proteins. A number of observations suggest that BBF-2 is involved in fat body-specific expression: Mutations that disrupt BBF-2 binding to two different Adh fat body enhancers in vitro decrease the activity of these enhancers in transgenic flies. BBF-2 mRNA is present in all cell types examined, and the protein is present in cells that express ADH. Finally, BBF-2 is a transcriptional activator in Drosophila tissue culture cells. Remarkably, BBF-2 also binds specifically to regulatory elements required for liver-specific expression of the human Adh and rat tyrosine aminotransferase genes. Thus, BBF-2 and the DNA sequence to which it binds may be important components of a tissue-specific regulatory mechanism conserved between Drosophila and man.  (+info)

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. (3/16)

Understanding how organs acquire the capacity to perform their respective functions is important for both cell and developmental biology. Here, we have examined the role of early-expressed transcription factors in activating genes crucial for secretory function in the Drosophila salivary gland. We show that expression of genes encoding proteins required for ER targeting and translocation, and proteins that mediate transport between the ER and Golgi is very high in the early salivary gland. This high level expression requires two early salivary gland transcription factors; CrebA is required throughout embryogenesis and Fkh is required only during late embryonic stages. As Fkh is required to maintain late CrebA expression in the salivary gland, Fkh probably works through CrebA to affect secretory pathway gene expression. In support of these regulatory interactions, we show that CrebA is important for elevated secretion in the salivary gland. Additionally, CrebA is required for the expression of the secretory pathway genes in the embryonic epidermis, where CrebA had previously been shown to be essential for cuticle development. We show that zygotic mutations in several individual secretory pathway genes result in larval cuticle phenotypes nearly identical to those of CrebA mutants. Thus, CrebA activity is linked to secretory function in multiple tissues.  (+info)

Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. (4/16)

(Fkh) is required to block salivary gland apoptosis, internalize salivary gland precursors, prevent expression of duct genes in secretory cells and maintain expression of CrebA, which is required for elevated secretory function. Here, we characterize two new Fkh-dependent genes: PH4alphaSG1 and PH4alphaSG2. We show through in vitro DNA-binding studies and in vivo expression assays that Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1. PH4alphaSG1 and PH4alphaSG2 encode alpha-subunits of resident ER enzymes that hydroxylate prolines in collagen and other secreted proteins. We demonstrate that salivary gland secretions are altered in embryos missing function of PH4alphaSG1 and PH4alphaSG2; secretory content is reduced and shows increased electron density by TEM. Interestingly, the altered secretory content results in regions of tube dilation and constriction, with intermittent tube closure. The regulation studies and phenotypic characterization of PH4alphaSG1 and PH4alphaSG2 link Fkh, which initiates tube formation, to the maintenance of an open and uniformly sized secretory tube.  (+info)

Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2. (5/16)

Direct bacterial conversion of the hemicellulose fraction of hardwoods and crop residues to biobased products depends upon extracellular depolymerization of methylglucuronoxylan (MeGAX(n)), followed by assimilation and intracellular conversion of aldouronates and xylooligosaccharides to fermentable xylose. Paenibacillus sp. strain JDR-2, an aggressively xylanolytic bacterium, secretes a multimodular cell-associated GH10 endoxylanase (XynA1) that catalyzes depolymerization of MeGAX(n) and rapidly assimilates the principal products, beta-1,4-xylobiose, beta-1,4-xylotriose, and MeGAX(3), the aldotetrauronate 4-O-methylglucuronosyl-alpha-1,2-xylotriose. Genomic libraries derived from this bacterium have now allowed cloning and sequencing of a unique aldouronate utilization gene cluster comprised of genes encoding signal transduction regulatory proteins, ABC transporter proteins, and the enzymes AguA (GH67 alpha-glucuronidase), XynA2 (GH10 endoxylanase), and XynB (GH43 beta-xylosidase/alpha-arabinofuranosidase). Expression of these genes, as well as xynA1 encoding the secreted GH10 endoxylanase, is induced by growth on MeGAX(n) and repressed by glucose. Sequences in the yesN, lplA, and xynA2 genes within the cluster and in the distal xynA1 gene show significant similarity to catabolite responsive element (cre) defined in Bacillus subtilis for recognition of the catabolite control protein (CcpA) and consequential repression of catabolic regulons. The aldouronate utilization gene cluster in Paenibacillus sp. strain JDR-2 operates as a regulon, coregulated with the expression of xynA1, conferring the ability for efficient assimilation and catabolism of the aldouronate product generated by a multimodular cell surface-anchored GH10 endoxylanase. This cluster offers a desirable metabolic potential for bacterial conversion of hemicellulose fractions of hardwood and crop residues to biobased products.  (+info)

Identification and analysis of two splice variants of human G2A generated by alternative splicing. (6/16)

 (+info)

The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. (7/16)

 (+info)

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (8/16)

 (+info)

*CAMP responsive element modulator

"Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB ...

*RELA

Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ... Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ...

*Activating transcription factor 2

Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (1990). "A cDNA for a human cyclic AMP response element-binding protein which is ... "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain". EMBO J. 8 (7): 2023-8. ... "Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32". Genomics. 11 ...

*ICAM-1

"ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF ... These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate ... The presence of heavy glycosylation and other structural characteristics of ICAM-1 lend the protein binding sites for numerous ... ICAM-1 possesses binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 ...

*C-jun

Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (1990). "A cDNA for a human cyclic AMP response element-binding protein which is ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... Venugopal R, Jaiswal AK (1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated ... c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response ...

*Kaang Bong-kiun

Lee JA, Kim H, Lee YS, Kaang BK (2003). "Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein- ... "AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic ... transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element-binding protein(CREB). ... he found that multiple pulses of serotonin stimulate gene expression that is mediated by the cAMP-response element(CRE). He ...

*Nerve growth factor

... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor. Phosphorylated CREB ... Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. ... This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf. Raf in turn activates the ...

*Epigenetics of depression

Cyclic-AMP Response Element Binding Protein (CREB), which is thought to be involved in GDNF regulation, associates with the ... CREB Binding Protein. Therefore, this antidepressant, by increasing acetylation, works to lessen the HPA response, and as a ... It is thought that this is happening due to an interaction between the response element of GR and the acetyltransferase, ... Furthermore, the methylation of the promoter region results in a decrease in recruitment of the CREB-Binding Protein (CBP), ...

*Barrel cortex

... calmodulin-dependent protein kinase II (CaMKII) or cyclic-AMP response element binding protein (CREB). In these mice, ... Stimulation of multiple whiskers may produce a response that is equal to the sum of the responses if each whisker was ... In deprived cortex, neuronal responses to spared whiskers are enhanced and responses to deprived whiskers are weakened. These ... with the weakening of deprived response preceding the strengthening of spared response, implying that they have different ...

*CREB

Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... 170-6. ISBN 978-0-87893-697-7. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. ... The protein also has a magnesium ion that facilitates binding to DNA. The cAMP response element (CRE) is the response element ... CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP ...

*Activity-regulated cytoskeleton-associated protein

7 kb upstream that contains binding sites for cyclic AMP response element-binding protein (CREB), myocyte enhancer factor 2 ( ... a serum response element (SRE; see serum response factor) at ~1.5 kb upstream of the initiation site. a second SRE at ~6.5 kb; ... The common factor for these signaling molecules involves activation of cyclic-AMP and its downstream target protein kinase A ( ... Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively. ...

*Molecular and epigenetic mechanisms of alcoholism

Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ... cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. Alcohol Clin Exp ...

*CREB-binding protein

Parry GC, Mackman N (December 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB ... "cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response ... First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 (3): 751-8. doi:10.1042 ...

*Follicle-stimulating hormone receptor

DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ... Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins, ...

*CREB5

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. The product of this ... cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... "Entrez Gene: CREB5 cAMP responsive element binding protein 5". Human CREB5 genome location and CREB5 gene details page in the ...

*PFKFB3

... and progesterone response element. Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent ... N-terminal structure that secures the binding of fructose-6-phosphate to the active site via interaction with the protein's '2- ... The promoter of PFKFB3 contains binding sites, called hypoxia response elements (HREs), that recruit the binding of hypoxia- ... The PFKFB3 promoter is predicted to contain multiple binding sites, including Sp-1 and AP-2 binding sites. It also contains ...

*CREB1

Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ... is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by ...

*CREB/ATF bZIP transcription factor

"Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element". FEBS Lett. 580 (1): 58-62 ... Akhova O, Bainbridge M, Misra V (2005). "The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus ... CREB/ATF bZIP transcription factor is a protein that in humans is encoded by the CREBZF gene. GRCh38: Ensembl release 89: ... "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman". J. Biol. Chem. 280 (15 ...

*Neuronal memory allocation

... cyclic AMP responsive element-binding protein) in this process. Certain synapses on recruited neurons are more likely to ... The transcription factor cAMP response element-binding protein (CREB) is a well-studied mechanism of neuronal memory allocation ... Nguyen, P. V., & Woo, N. H. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...

*ATF1

Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ... Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A". J. ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ...

*TAF4

Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (1999). "The cyclic AMP response element ... CBX5m TATA binding protein, and Transcription initiation protein SPT3 homolog. Yeast TFIID comprises the TATA binding protein ... and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ...

*Hormone receptor

heir response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The ... These receptors generally function via intracellular second messengers, including cyclic AMP (cAMP), cyclic GMP (cGMP), ... Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. Because of the relatively ... A hormone receptor is a receptor molecule that binds to a specific hormone. Hormone receptors are a wide family of proteins ...

*CEBPB

"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this ... In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ...

*Eric Kandel

One of the nuclear targets for PKA is the transcriptional control protein CREB (cAMP response element binding protein). In ... By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in Aplysia ganglia under conditions ... By 1980, collaboration with Paul Greengard resulted in demonstration that cAMP-dependent protein kinase, also known as protein ... The Kandel lab then sought to identify proteins that had to be synthesized to convert short-term memories into long-lasting ...

*ATF5

... cAMP response-element binding protein (CREB) family. ATF5 transcripts and protein are expressed in a wide variety of tissues, ... Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP- ... "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol ... "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of ...

*Riboswitch

... "cyclic di-GMP" below). cyclic di-AMP riboswitches (also called ydaO/yuaA) bind the signaling molecule cyclic di-AMP. cyclic di- ... including protein-free binding assays, and metabolite-binding riboswitches were established as a new mechanism of gene ... The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the ... Cobalamin riboswitch (also B12-element), which binds either adenosylcobalamin (the coenzyme form of vitamin B12) or ...
Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating…
TY - JOUR. T1 - The C2H2 transcription factor REGULATOR OF SYMBIOSOME DIFFERENTIATION represses transcription of the secretory pathway gene VAMP721a and promotes symbiosome development in Medicago truncatula. AU - Sinharoy, Senjuti. AU - Torres-Jerez, Ivone. AU - Bandyopadhyay, Kaustav. AU - Kereszt, Attila. AU - Pislariu, Catalina I.. AU - Nakashima, Jin. AU - Benedito, Vagner A.. AU - Kondorosi, Eva. AU - Udvardi, Michael K.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Transcription factors (TFs) are thought to regulate many aspects of nodule and symbiosis development in legumes, although few TFs have been characterized functionally. Here, we describe REGULATOR OF SYMBIOSOME DIFFERENTIATION (RSD) of Medicago truncatula, a member of the Cysteine-2/Histidine-2 (C2H2) family of plant TFs that is required for normal symbiosome differentiation during nodule development. RSD is expressed in a nodule-specific manner, with maximal transcript levels in the bacterial invasion zone. A tobacco (Nicotiana tabacum) ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
ATF2 (pT73/T55) Antibody is a Rabbit Polyclonal antibody against ATF2 (pT73/T55). This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an o
Older research outputs will score higher simply because theyve had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,757 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries ...
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CG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM. ICG 001, a small molecule that down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. ICG001 selectively ind
TY - JOUR. T1 - ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE. T2 - II. COMPARISON WITH OTHER TESTS.. AU - Kaplan, Norman M. PY - 1963/9. Y1 - 1963/9. UR - http://www.scopus.com/inward/record.url?scp=75449131766&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=75449131766&partnerID=8YFLogxK. M3 - Article. C2 - 14064143. AN - SCOPUS:75449131766. VL - 23. SP - 953. EP - 960. JO - Journal of Clinical Endocrinology and Metabolism. JF - Journal of Clinical Endocrinology and Metabolism. SN - 0021-972X. ER - ...
Hox genes control regional identity during segmentation of the vertebrate hindbrain into rhombomeres. A transgenic analysis as used to investigate the upstream mechanisms for regulation of Hoxb-3 in rhombomere (r)5. Enhancers were identified from the promoter sequences of mouse and chick Hoxb-3 sufficient for r5-restricted expression. Sequence comparisons reveal two blocks of similarity (of 19 and 45 base pairs), which each contain in vitro binding sites for the kreisler protein (Kmrl1), a Maf/b-Zip protein expressed in r5 and r6. Kreisler (Krml1) is a member of a distinct basic leucine zipper family with some sequence homology in the basic DNA binding region to fos, jun, CREB and C/EBP. Both kreisler binding sites are required for r5 activity, suggesting that Hoxb-3 is a direct target of kreisler. Multimers of the 19-base-pair (bp) block recreate a Krml1-like pattern in r5/r6, but the 45-bp block mediates expression only in r5. Therefore elements within the 45-bp block restrict the response to ...
TOKYO (AP) - Warning Russia that new economic sanctions are teed up, President Barack Obama accused Moscow of failing to live up to an agreement last week to ease tensions in eastern Ukraine.
Slow morning. It looks overcast but the breeze that still blows through my open window is warm. I have the day ahead of me before I will join my tour for dinner this evening. I make it down for breakfast in the basement of the Nacional - buffet tables of fruit, pastries, meats and cheeses, an…
Whats a transcription factor of the basic helix-loop-helix leucine zipper family doing in the cytoplasm? Sans et al. explored why nearly all of the transcription factor MondoA and its binding partner protein called Mlx is found in the cytoplasm but the protein appears to function as a transcription factor in the nucleus. The authors found that in primary cultures of human muscle or erythroblast cells, MondoA and Mlx were associated with the mitochondria. Inhibition of nuclear shuttling of the proteins with an inhibitor of the CRM1 nuclear export factor caused MondoA (detected by confocal immunofluorescence microscopy) to accumulate in the nucleus. Thus, the authors suspected that MondoA could function to carry signals from the mitochondria to the nucleus. They obtained further circumstantial evidence for such a role from microarray experiments designed to detect genes transcribed in response to MondoA and Mlx. MondoA-Mlx regulated a broad range of targets, which included many genes associated ...
Compounds are provided which have the structure |chemistry-cwu id=CHEM-US-00001 st32-name=CHEM-US|1|image id=EMI-C00001 he=59.27985 wi=215.31825 file=US20030130306A1-20030710-C00001.TIF

Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...

Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... Cyclic AMP response element-binding protein H (CREBH) was identified as a liver-specific bZIP transcription factor [10, 11]. ... The cyclic AMP response element-binding protein H (CREBH) plays important roles in hepatic lipogenesis, fatty acid oxidation, ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ...
more infohttps://www.hindawi.com/journals/bmri/2013/892491/

CAMP responsive element modulator - WikipediaCAMP responsive element modulator - Wikipedia

"Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB ...
more infohttps://en.wikipedia.org/wiki/CAMP_responsive_element_modulator

Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene...Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene...

Cyclic AMP Response Element-Binding Protein Response Elements Genes Vascular Endothelial Growth Factor Receptor-1 ... it is shown that cAMP response element binding protein (CREB) and nuclear factor-kappaB (NF-kappaB)-related antigens bind ... it is shown that cAMP response element binding protein (CREB) and nuclear factor-kappaB (NF-kappaB)-related antigens bind ... it is shown that cAMP response element binding protein (CREB) and nuclear factor-kappaB (NF-kappaB)-related antigens bind ...
more infohttps://moh-it.pure.elsevier.com/en/publications/nuclear-factor-kappab-and-camp-response-element-binding-protein-m

Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...

Xie, F, Fan, Q, Li, BX & Xiao, X 2019, Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)- ... Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15. ... Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15 ... Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15 ...
more infohttps://ohsu.pure.elsevier.com/en/publications/discovery-of-a-synergistic-inhibitor-of-camp-response-element-bin

Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription<...Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription<...

cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the pathogenesis and ... abstract = "cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the ... N2 - cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the ... AB - cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the ...
more infohttps://ohsu.pure.elsevier.com/en/publications/design-synthesis-and-biological-evaluation-of-regioisomers-of-666

Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients | SpringerLinkEffect of treatment on serum brain-derived neurotrophic factor levels in depressed patients | SpringerLink

Roseboom PH, Klein DC (1995) Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation, ... Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat ... Thome J, Saka N, Shin K, Steffen C, Zhang YJ, Impey S, Storm D, Duman RS (2000) cAMP response element-mediated gene ... primary role of a beta-adrenergic receptor/cyclic AMP mechanism. Mol Pharmacol 47:439-449PubMedGoogle Scholar ...
more infohttps://link.springer.com/article/10.1007%2Fs00406-005-0578-6

OriGene - Crem (NM 001110859) Human ORF cDNA CloneOriGene - Crem (NM 001110859) Human ORF cDNA Clone

Mouse cAMP responsive element modulator (Crem), transcript variant 1 available for purchase from OriGene - Your Gene Company. ... where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either ... Lenti-ORF clone of CREM (Myc-DDK-tagged)-Human cAMP responsive element modulator (CREM), transcript variant 4. $580. 8 weeks. ... Lenti-ORF clone of CREM (Myc-DDK-tagged)-Human cAMP responsive element modulator (CREM), transcript variant 5. $580. 8 weeks. ...
more infohttp://www.origene.com/Mouse_ORF/MR224371.aspx

Active Motif » TransAM CREB (cyclic AMP response element binding, CREB and Phosphorylated CREB (Ser133) DNA binding ELISAs)Active Motif » TransAM CREB (cyclic AMP response element binding, CREB and Phosphorylated CREB (Ser133) DNA binding ELISAs)

TransAM CREB and TransAM pCREB Kits are DNA-binding ELISAs that quanify the activated transcription factors using a method that ... Cyclic AMP Response Element-Binding (CREB) protein is critical in a variety of cellular processes such as cell proliferation, ... TransAM CREB and TransAM pCREB Kits provide everything needed to study activated Cyclic AMP Response Element Binding (CREB), ... Both phosphorylation at Ser133 and the binding of coactivator CBP (CREB-binding protein) are required to induce CREB-mediated ...
more infohttp://www.activemotif.jp/catalog/192/transam-creb-pcreb

Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...

Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ... acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H," ... cAMP responsive element-binding protein H)," Journal of Biological Chemistry, vol. 286, no. 49, pp. 41972-41984, 2011. View at ...
more infohttps://www.hindawi.com/journals/bmri/2013/892491/ref/

Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human...Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human...

Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ...
more infohttps://jvi.asm.org/content/75/4/1842?ijkey=b70e35753a95ccf8a7ccfbee49b930b0e54eba6c&keytype2=tf_ipsecsha

Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene...Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene...

Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ...
more infohttp://molpharm.aspetjournals.org/content/47/6/1112?ijkey=f57d00757d2925a7aa5b7959df46805804181fdf&keytype2=tf_ipsecsha

Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta...Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta...

Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ...
more infohttp://molpharm.aspetjournals.org/content/47/3/439

Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...

... report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements ( ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...
more infohttps://www.semanticscholar.org/paper/Mitochondrial-cyclic-AMP-response-element-binding-Lee-Kim/33f24fbed87b7159e66af9edc651c7da51fd52f8

Cyclic AMP Response Element-Binding Protein | The Chopra LibraryCyclic AMP Response Element-Binding Protein | The Chopra Library

Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor- ... the neurogenic potential of EGb 761 and its effect on cAMP response element binding protein (CREB) were examined in a double ... The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to ... CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. ...
more infohttp://isharonline.org/tags/cyclic-amp-response-element-binding-protein

Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit - Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA...Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit - Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA...

Cyclic AMP Response Element Binding Protein) ELISA Kit based in Delhi, India ... Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit ... Rat CHD3(Chromodomain Helicase DNA Binding Protein 3) ELISA Kit. *Rat CHD5(Chromodomain Helicase DNA Binding Protein 5) ELISA ... Rat MBP-C/MBL2(Mannma Binding Protein C/Mannan Binding Lectin 2) ELISA Kit ...
more infohttp://www.srgroupchemical.com/rat-creb-cyclic-amp-response-element-binding-protein-elisa-kit-4472778.html

Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in...Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in...

Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... stim ulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein ( ...
more infohttps://www.iris.unict.it/handle/20.500.11769/318458

Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced...Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced...

Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced ... Cyclic AMP Response Element-Binding Protein/immunology. *Cyclic AMP Response Element-Binding Protein/metabolism* ... We demonstrate cAMP response element (CRE)-binding activity in CNS protein extracts and show that one of the CRE-binding ... cyclic adenosine 3,5-monophosphate (cAMP) response element-binding protein (CREB) are conserved key steps in the molecular ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12956721?dopt=Abstract

Frontiers | Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling | Frontiers...Frontiers | Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling | Frontiers...

Cyclic AMP Response Element-Binding Protein. Role of CREB in Axon Growth and Regeneration. During development, several ... axon growth by regulation of gene expression via the transcription factor cyclic AMP response element-binding protein (CREB; ... cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding ... and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by ...
more infohttps://www.frontiersin.org/articles/10.3389/fnmol.2012.00003/full

finals - gene expression Flashcards by Estee C | Brainscapefinals - gene expression Flashcards by Estee C | Brainscape

cyclic AMP response element binding protein 73 ____ the co activator of CREB ... an example of a response element that binds to heat-specific transcription factors that are produced by elevated temperatures ... d. one transcription activator can bind to the same response element in multiple genes that each have unique promoters and ... a. consists of a single protein with two similar domains. b. Binding of TBP distorts DNA at TATA box. c. binding creates an 80 ...
more infohttps://www.brainscape.com/flashcards/finals-gene-expression-4548148/packs/6223664

The quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain | SpringerLinkThe quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain | SpringerLink

FIH, factor inhibiting HIF; CBP, cyclic AMP-response element binding protein; HRE, hypoxia response element ... However, in hypoxia, HIF-1α hydroxylation does not occur, stabilizing HIF-1 where it binds to a hypoxia response element ... Assuming an average cerebral tissue partial pressure of O2 (PcO2) of ~ 25 mmHg and lack of O2-binding proteins, the brains O2 ... As an element, oxygen (O) is unique; it is the third most abundant element in the universe after hydrogen and helium, the ...
more infohttps://link.springer.com/article/10.1186%2Fs42234-018-0014-7

Current Issue : Anti-Cancer DrugsCurrent Issue : Anti-Cancer Drugs

Discovery of selective inhibitors for cyclic AMP response element-binding protein: a combined ligand and structure-based ... ABT-737 and erufosine combination against castration-resistant prostate cancer: a promising but cell-type specific response ...
more infohttps://journals.lww.com/anti-cancerdrugs/pages/currenttoc.aspx

GPER | Cancer Genetics WebGPER | Cancer Genetics Web

Cyclic AMP Response Element-Binding Protein. *Culture Media, Conditioned. *Insulin-Like Growth Factor Binding Protein 1 ... G-protein coupled receptor activity - G-protein coupled receptor signaling pathway - Golgi membrane - hormone binding - ... The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5- ... Screening and Identification of a Phage Display Derived Peptide That Specifically Binds to the CD44 Protein Region Encoded by ...
more infohttp://www.cancerindex.org/geneweb/GPER.htm

Genome-wide transcriptional profiling linked to social class in asthma | ThoraxGenome-wide transcriptional profiling linked to social class in asthma | Thorax

AP1, activator protein 1; CREB, cyclic AMP response element binding protein; NFκB, nuclear factor κB; NF-Y, nuclear factor Y.. ... Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y ... Cyclic AMP response element binding protein (CREB) TFBMs were significantly less prevalent in promoters of genes overexpressed ... Regulation of asthma-related T-cell cytokines by the cyclic AMP-dependent signalling pathway. Clin Exp Allergy 2000;30:920-6. ...
more infohttps://thorax.bmj.com/content/64/1/38?ijkey=80ef4692de676d47c5f9aa5e843b78bf2c752598&keytype2=tf_ipsecsha

Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayamas disease: clinical,...Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama's disease: clinical,...

0/Cyclic AMP Response Element-Binding Protein; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 0/SMN Complex Proteins; 0/SMN1 ... Cyclic AMP Response Element-Binding Protein / genetics*. Electromyography. Female. Forearm / innervation*. Genetic ... RNA-Binding Proteins / genetics*. SMN Complex Proteins. Spain. Spinal Cord / pathology. Survival of Motor Neuron 1 Protein. ... protein, human; 0/SMN2 protein, human; 0/Survival of Motor Neuron 1 Protein; 0/Survival of Motor Neuron 2 Protein ...
more infohttp://www.biomedsearch.com/nih/Investigation-role-SMN1-SMN2-haploinsufficiency/17850955.html

Ras Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics - PubMedRas Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics - PubMed

The activation of the extracellular signal-regulated kinases 1 and 2 (ERK1,2) and cAMP response element-binding protein (CREB)- ... Cyclic AMP Response Element-Binding Protein / metabolism Actions. * Search in PubMed * Search in MeSH ... The activation of the extracellular signal-regulated kinases 1 and 2 (ERK1,2) and cAMP response element-binding protein (CREB)- ... Protein Kinases in the Photic Signaling of the Mammalian Circadian Clock. Alessandro MS, Golombek DA, Chiesa JJ. Alessandro MS ...
more infohttps://pubmed.ncbi.nlm.nih.gov/25762011/
  • Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. (springer.com)
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