A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.
A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Established cell cultures that have the potential to propagate indefinitely.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
Nucleic acid sequences involved in regulating the expression of genes.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. (1/16)

In this report, we describe the isolation and initial characterization of a Drosophila protein, dCREB-A, that can bind the somatostatin cyclic AMP (cAMP)-responsive element and is capable of activating transcription in cell culture. Sequence analysis demonstrates that this protein is a member of the leucine zipper family of transcription factors. dCREB-A is unusual in that it contains six hydrophobic residue iterations in the zipper domain rather than the four or five commonly found in this group of proteins. The DNA-binding domain is more closely related to mammalian CREB than to the AP-1 factors in both sequence homology and specificity of cAMP-responsive element binding. In embryos, dCREB-A is expressed in the developing salivary gland. A more complex pattern of expression is detected in the adult; transcripts are found in the brain and optic lobe cell bodies, salivary gland, and midgut epithelial cells of the cardia. In females, dCREB-A is expressed in the ovarian columnar follicle cells, and in males, dCREB-A RNA is seen in the seminal vesicle, ejaculatory duct, and ejaculatory bulb. These results suggest that the dCREB-A transcription factor may be involved in fertility and neurological functions.  (+info)

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (2/16)

We have identified a Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes. DNA sequence analysis of cDNA clones encoding this protein, box B-binding factor-2 (BBF-2), indicates that it is a member of the CREB/ATF family of transcriptional regulatory proteins. A number of observations suggest that BBF-2 is involved in fat body-specific expression: Mutations that disrupt BBF-2 binding to two different Adh fat body enhancers in vitro decrease the activity of these enhancers in transgenic flies. BBF-2 mRNA is present in all cell types examined, and the protein is present in cells that express ADH. Finally, BBF-2 is a transcriptional activator in Drosophila tissue culture cells. Remarkably, BBF-2 also binds specifically to regulatory elements required for liver-specific expression of the human Adh and rat tyrosine aminotransferase genes. Thus, BBF-2 and the DNA sequence to which it binds may be important components of a tissue-specific regulatory mechanism conserved between Drosophila and man.  (+info)

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. (3/16)

Understanding how organs acquire the capacity to perform their respective functions is important for both cell and developmental biology. Here, we have examined the role of early-expressed transcription factors in activating genes crucial for secretory function in the Drosophila salivary gland. We show that expression of genes encoding proteins required for ER targeting and translocation, and proteins that mediate transport between the ER and Golgi is very high in the early salivary gland. This high level expression requires two early salivary gland transcription factors; CrebA is required throughout embryogenesis and Fkh is required only during late embryonic stages. As Fkh is required to maintain late CrebA expression in the salivary gland, Fkh probably works through CrebA to affect secretory pathway gene expression. In support of these regulatory interactions, we show that CrebA is important for elevated secretion in the salivary gland. Additionally, CrebA is required for the expression of the secretory pathway genes in the embryonic epidermis, where CrebA had previously been shown to be essential for cuticle development. We show that zygotic mutations in several individual secretory pathway genes result in larval cuticle phenotypes nearly identical to those of CrebA mutants. Thus, CrebA activity is linked to secretory function in multiple tissues.  (+info)

Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. (4/16)

(Fkh) is required to block salivary gland apoptosis, internalize salivary gland precursors, prevent expression of duct genes in secretory cells and maintain expression of CrebA, which is required for elevated secretory function. Here, we characterize two new Fkh-dependent genes: PH4alphaSG1 and PH4alphaSG2. We show through in vitro DNA-binding studies and in vivo expression assays that Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1. PH4alphaSG1 and PH4alphaSG2 encode alpha-subunits of resident ER enzymes that hydroxylate prolines in collagen and other secreted proteins. We demonstrate that salivary gland secretions are altered in embryos missing function of PH4alphaSG1 and PH4alphaSG2; secretory content is reduced and shows increased electron density by TEM. Interestingly, the altered secretory content results in regions of tube dilation and constriction, with intermittent tube closure. The regulation studies and phenotypic characterization of PH4alphaSG1 and PH4alphaSG2 link Fkh, which initiates tube formation, to the maintenance of an open and uniformly sized secretory tube.  (+info)

Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2. (5/16)

Direct bacterial conversion of the hemicellulose fraction of hardwoods and crop residues to biobased products depends upon extracellular depolymerization of methylglucuronoxylan (MeGAX(n)), followed by assimilation and intracellular conversion of aldouronates and xylooligosaccharides to fermentable xylose. Paenibacillus sp. strain JDR-2, an aggressively xylanolytic bacterium, secretes a multimodular cell-associated GH10 endoxylanase (XynA1) that catalyzes depolymerization of MeGAX(n) and rapidly assimilates the principal products, beta-1,4-xylobiose, beta-1,4-xylotriose, and MeGAX(3), the aldotetrauronate 4-O-methylglucuronosyl-alpha-1,2-xylotriose. Genomic libraries derived from this bacterium have now allowed cloning and sequencing of a unique aldouronate utilization gene cluster comprised of genes encoding signal transduction regulatory proteins, ABC transporter proteins, and the enzymes AguA (GH67 alpha-glucuronidase), XynA2 (GH10 endoxylanase), and XynB (GH43 beta-xylosidase/alpha-arabinofuranosidase). Expression of these genes, as well as xynA1 encoding the secreted GH10 endoxylanase, is induced by growth on MeGAX(n) and repressed by glucose. Sequences in the yesN, lplA, and xynA2 genes within the cluster and in the distal xynA1 gene show significant similarity to catabolite responsive element (cre) defined in Bacillus subtilis for recognition of the catabolite control protein (CcpA) and consequential repression of catabolic regulons. The aldouronate utilization gene cluster in Paenibacillus sp. strain JDR-2 operates as a regulon, coregulated with the expression of xynA1, conferring the ability for efficient assimilation and catabolism of the aldouronate product generated by a multimodular cell surface-anchored GH10 endoxylanase. This cluster offers a desirable metabolic potential for bacterial conversion of hemicellulose fractions of hardwood and crop residues to biobased products.  (+info)

Identification and analysis of two splice variants of human G2A generated by alternative splicing. (6/16)

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The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. (7/16)

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The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (8/16)

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Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating…
TY - JOUR. T1 - The C2H2 transcription factor REGULATOR OF SYMBIOSOME DIFFERENTIATION represses transcription of the secretory pathway gene VAMP721a and promotes symbiosome development in Medicago truncatula. AU - Sinharoy, Senjuti. AU - Torres-Jerez, Ivone. AU - Bandyopadhyay, Kaustav. AU - Kereszt, Attila. AU - Pislariu, Catalina I.. AU - Nakashima, Jin. AU - Benedito, Vagner A.. AU - Kondorosi, Eva. AU - Udvardi, Michael K.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Transcription factors (TFs) are thought to regulate many aspects of nodule and symbiosis development in legumes, although few TFs have been characterized functionally. Here, we describe REGULATOR OF SYMBIOSOME DIFFERENTIATION (RSD) of Medicago truncatula, a member of the Cysteine-2/Histidine-2 (C2H2) family of plant TFs that is required for normal symbiosome differentiation during nodule development. RSD is expressed in a nodule-specific manner, with maximal transcript levels in the bacterial invasion zone. A tobacco (Nicotiana tabacum) ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
ATF2 (pT73/T55) Antibody is a Rabbit Polyclonal antibody against ATF2 (pT73/T55). This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an o
Older research outputs will score higher simply because theyve had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,757 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries ...
Members of the genus Bifidobacterium are commonly found in the gastrointestinal tracts of mammals, including humans, where their growth is presumed to be dependent on various diet- and/or host-derived carbohydrates. To understand transcriptional control of bifidobacterial carbohydrate metabolism, we investigated two genetic carbohydrate utilization clusters dedicated to the metabolism of ... read more raffinose-type sugars and melezitose. Transcriptomic and gene inactivation approaches revealed that the raffinose utilization system is positively regulated by an activator protein, designated RafR. The gene cluster associated with melezitose metabolism was shown to be subject to direct negative control by a LacI-type transcriptional regulator, designated MelR1, in addition to apparent indirect negative control by means of a second LacI-type regulator, MelR2. In silico analysis, DNA-protein interaction, and primer extension studies revealed the MelR1 and MelR2 operator sequences, each of which is ...
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CG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM. ICG 001, a small molecule that down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. ICG001 selectively ind
Drosophila melanogaster Larval cuticle protein 3 (Lcp3) datasheet and description hight quality product and Backed by our Guarantee
NFIL3 (Nuclear Factor, Interleukin 3 Regulated), also called E4BP4 (adenovirus E4 promoter binding protein 4), is an approximately 58 kDa transcription factor of the bZIP (basic leucine zipper) family. It is a transcriptional regulator expressed in T and pro-B lymphocytes and cardiomyocytes, binds IL-3 and promoters as a homodimer, and enhances cell survival. NFIL3 has also been shown to be involved in the development of Innate Lymphoid Cells (ILCs; 1,2). The 462 amino acid (aa) human NFIL3 contains a basic DNA binding domain (aa 73-95), a leucine zipper (aa 96-124), and a transcriptional repression domain (aa 299-363) that is potentially regulated by phosphorylation at Ser301 and Ser353. Within the region used as an immunogen, human NFIL3 shares 83% aa sequence identity with mouse and rat NFIL3 ...
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TY - JOUR. T1 - ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE. T2 - II. COMPARISON WITH OTHER TESTS.. AU - Kaplan, Norman M. PY - 1963/9. Y1 - 1963/9. UR - http://www.scopus.com/inward/record.url?scp=75449131766&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=75449131766&partnerID=8YFLogxK. M3 - Article. C2 - 14064143. AN - SCOPUS:75449131766. VL - 23. SP - 953. EP - 960. JO - Journal of Clinical Endocrinology and Metabolism. JF - Journal of Clinical Endocrinology and Metabolism. SN - 0021-972X. ER - ...
Hox genes control regional identity during segmentation of the vertebrate hindbrain into rhombomeres. A transgenic analysis as used to investigate the upstream mechanisms for regulation of Hoxb-3 in rhombomere (r)5. Enhancers were identified from the promoter sequences of mouse and chick Hoxb-3 sufficient for r5-restricted expression. Sequence comparisons reveal two blocks of similarity (of 19 and 45 base pairs), which each contain in vitro binding sites for the kreisler protein (Kmrl1), a Maf/b-Zip protein expressed in r5 and r6. Kreisler (Krml1) is a member of a distinct basic leucine zipper family with some sequence homology in the basic DNA binding region to fos, jun, CREB and C/EBP. Both kreisler binding sites are required for r5 activity, suggesting that Hoxb-3 is a direct target of kreisler. Multimers of the 19-base-pair (bp) block recreate a Krml1-like pattern in r5/r6, but the 45-bp block mediates expression only in r5. Therefore elements within the 45-bp block restrict the response to ...
TOKYO (AP) - Warning Russia that new economic sanctions are teed up, President Barack Obama accused Moscow of failing to live up to an agreement last week to ease tensions in eastern Ukraine.
Slow morning. It looks overcast but the breeze that still blows through my open window is warm. I have the day ahead of me before I will join my tour for dinner this evening. I make it down for breakfast in the basement of the Nacional - buffet tables of fruit, pastries, meats and cheeses, an…
Whats a transcription factor of the basic helix-loop-helix leucine zipper family doing in the cytoplasm? Sans et al. explored why nearly all of the transcription factor MondoA and its binding partner protein called Mlx is found in the cytoplasm but the protein appears to function as a transcription factor in the nucleus. The authors found that in primary cultures of human muscle or erythroblast cells, MondoA and Mlx were associated with the mitochondria. Inhibition of nuclear shuttling of the proteins with an inhibitor of the CRM1 nuclear export factor caused MondoA (detected by confocal immunofluorescence microscopy) to accumulate in the nucleus. Thus, the authors suspected that MondoA could function to carry signals from the mitochondria to the nucleus. They obtained further circumstantial evidence for such a role from microarray experiments designed to detect genes transcribed in response to MondoA and Mlx. MondoA-Mlx regulated a broad range of targets, which included many genes associated ...
The cover image illustrates the relationship between βHeavy-spectrin (in green) and Coracle (in red) in the tubular Drosophila salivary gland epithelium. βH-spectrin is heavily concentrated at the apical lumenal surface, whereas Coracle is limited to the apical−lateral septate junctions at the cell boundaries. This image was made through a maximum projection of a confocal data stack. The boundary between these two domains is degraded in the absence of the βH-spectrin-binding protein Annexin B9. See Tjota et al. (pp. 2914-2926). ...
Compounds are provided which have the structure |chemistry-cwu id=CHEM-US-00001 st32-name=CHEM-US|1|image id=EMI-C00001 he=59.27985 wi=215.31825 file=US20030130306A1-20030710-C00001.TIF
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... The protein also has a magnesium ion that facilitates binding to DNA. The cAMP response element (CRE) is the response element ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ...
Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ... Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ...
Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (1990). "A cDNA for a human cyclic AMP response element-binding protein which is ... "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain". EMBO J. 8 (7): 2023-8. ... "Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32". Genomics. 11 ...
"ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF ... These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate ... The presence of heavy glycosylation and other structural characteristics of ICAM-1 lend the protein binding sites for numerous ... ICAM-1 possesses binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 ...
GSK-3β inhibits the transcription factors β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by ... Lithium was found to increase the basal levels of cyclic AMP but impair receptor coupled stimulation of cyclic AMP production. ... It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP production ... Over a long period of lithium treatment, cyclic AMP and adenylate cyclase levels are further changed by gene transcription ...
The structure of cyclic-AMP response element binding protein (CBP) and E1A complex was determined by NMR. It reveals that CR1 ... Early proteins typically encode non-structural proteins that are necessary for replication, whereas late structural proteins ... "The Structure of the Site on Adenovirus Early Region 1A Responsible for Binding to TATA-binding Protein Determined by NMR ... The fixed structure allows this domain to recognize TATA-binding protein (TBP) and activate transcription of certain genes. The ...
Lee JA, Kim H, Lee YS, Kaang BK (2003). "Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein- ... "AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic ... transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element-binding protein(CREB). ... he found that multiple pulses of serotonin stimulate gene expression that is mediated by the cAMP-response element(CRE). He ...
... action potentials have been shown to induce BDNF-dependent phosphorylation of cyclic AMP response element-binding protein (CREB ... This change also affects future integration of signals, leading to at least a short-term response difference between the ... boosting synaptic responses, resetting membrane potential, retrograde actions at synapses and conditional axonal output. ...
Cyclic-AMP response element-binding protein (CREB), which is thought to be involved in GDNF regulation, associates with the ... cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein ... CREB Binding Protein. Therefore, this antidepressant, by increasing acetylation, works to lessen the HPA response, and as a ... It is thought that this is happening due to an interaction between the response element of GR and the acetyltransferase, ...
... calmodulin-dependent protein kinase II (CaMKII) or cyclic-AMP response element binding protein (CREB). In these mice, ... Stimulation of multiple whiskers may produce a response that is equal to the sum of the responses if each whisker was ... In deprived cortex, neuronal responses to spared whiskers are enhanced and responses to deprived whiskers are weakened. These ... with the weakening of deprived response preceding the strengthening of spared response, implying that they have different ...
Cyclic AMP-response Element Binding (protein) CREEP - (a) Committee for the Re-Election of the President, a pejorative nickname ... Cyclic Code Shift Keying CCT - (i) Current Commitments Team CCTT - (i) Close Combat Tactical Trainer cd - (s) Candela Cd - (s) ... Computer Emergency Response Team ces - (s) Czech language (ISO 639-2 code) CESS - (i) Centre for Earth Science Studies (India) ... from the chemical symbols of the two component elements) CUW - (s) Curaçao (ISO 3166 trigram) cv - (s) Chuvash language (ISO ...
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ... Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins, ...
Parry GC, Mackman N (December 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB ... "cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response ... First isolated as a nuclear protein [Ref] that binds to cAMP-response element-binding protein (CREB), this gene is now known to ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 ( Pt 3) (3): 751-8. doi ...
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB ...
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ... cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. Alcohol Clin Exp ...
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor. Phosphorylated CREB ... Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. ... This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf. Raf in turn activates the ...
... β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by phosphorylation. This results in a decrease in the ... Lithium was found to increase the basal levels of cyclic AMP but impair receptor coupled stimulation of cyclic AMP production.[ ... 72] It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP ... Cyclic AMP secondary messengersEdit. Lithium's therapeutic effects are thought to be partially attributable to its interactions ...
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor.[7] Phosphorylated CREB ... protein binding. • metalloendopeptidase inhibitor activity. • nerve growth factor receptor binding. • growth factor activity. • ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf.[7] Raf in turn activates ... Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. ...
Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. The product of this ... cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... "Entrez Gene: CREB5 cAMP responsive element binding protein 5". Cumulated Index Medicus. U.S. Department of Health and Human ...
... and progesterone response element. Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent ... N-terminal structure that secures the binding of fructose-6-phosphate to the active site via interaction with the protein's '2- ... The promoter of PFKFB3 contains binding sites, called hypoxia response elements (HREs), that recruit the binding of hypoxia- ... The PFKFB3 promoter is predicted to contain multiple binding sites, including Sp-1 and AP-2 binding sites. It also contains ...
Specifically, estrogen increased cAMP activity and cAMP response element-binding protein phosphorylation in neuroblastoma cells ... modulated by estrogen in both human SK-N-SH neuroblastoma cell cultures as well as in mice through interactions with cyclic AMP ... Additionally, neurotensin gene transcription was blocked in knock-out mice lacking the RIIβ subunit of the protein kinase A ... Neurotensin is synthesized as part of a 169 or 170 amino acid precursor protein that also contains the related neuropeptide ...
7 kb upstream that contains binding sites for cyclic AMP response element-binding protein (CREB), myocyte enhancer factor 2 ( ... a serum response element (SRE; see serum response factor) at ~1.5 kb upstream of the initiation site. a second SRE at ~6.5 kb; ... The common factor for these signaling molecules involves activation of cyclic-AMP and its downstream target protein kinase A ( ... Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively. ...
Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ... is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on ...
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... G-protein coupled peptide receptor activity. • G-protein coupled receptor activity. • choriogonadotropin hormone binding. • ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ...
Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ... Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.". J. ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ...
... cyclic AMP responsive element-binding protein) in this process. Certain synapses on recruited neurons are more likely to ... The transcription factor cAMP response element-binding protein (CREB) is a well-studied mechanism of neuronal memory allocation ... Nguyen, P. V., & Woo, N. H. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...
Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (1999). "The cyclic AMP response element ... CBX5m TATA binding protein, and Transcription initiation protein SPT3 homolog. Yeast TFIID comprises the TATA binding protein ... and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ...
Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The ... These receptors generally function via intracellular second messengers, including cyclic AMP (cAMP), cyclic GMP (cGMP), ... The features of G proteins include GDP/GTP binding, GTP hydrolysis and guanosine nucleotide exchange. When a ligand binds to a ... Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. Because of the relatively ...
"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this ... In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ...
One of the nuclear targets for PKA is the transcriptional control protein CREB (cAMP response element binding protein).[5] In ... By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in Aplysia ganglia under conditions ... By 1980, collaboration with Paul Greengard resulted in demonstration that cAMP-dependent protein kinase, also known as protein ... The Kandel lab then sought to identify proteins that had to be synthesized to convert short-term memories into long-lasting ...
Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their ... Białko CD39 umożliwia rozkład ATP do ADP lub AMP[92]. Drugim istotnym elementem jest cząsteczka CD73, która z kolei przetwarza ... Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. „J Exp Med". 204 (6), s. 1303-1310 ... Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory ...
... p38 mitogen-activated protein kinases (p38 Mpk), and cAMP response element-binding protein (CREB) which when activated ... production of cyclic AMP [cAMP]);[5] e) G proteins types to which they link and activate, i.e. those containing the Gs alpha ... G protein linkage[2]. pathways[2] Prostaglandin DP1 receptor. DP1. PGD2,,PGE2,PGF2α,PGI2=TXA2[6]. relaxant. Gs alpha subunit. ... "Prostanoid receptors - G protein-coupled receptors - IUPHAR/BPS Guide to PHARMACOLOGY". www.guidetopharmacology.org.. ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... Metal/element. *calcium *Calcium-binding protein. *Calmodulin-binding proteins. *copper *Ceruloplasmin. *iron *Iron-binding ... G proteins, second messengers, the enzymes that trigger protein phosphorylation in response to cAMP, and consequent metabolic ... G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside ...
... and were eventually shown to encode components of an intracellular signaling pathway involving cyclic AMP, protein kinase A, ... Calcium binds to proteins such as calmodulin (CaM) and an eye-specific protein kinase C (PKC) known as InaC. These proteins ... interact with other proteins and have been shown to be necessary for shut off of the light response. In addition, proteins ... One approach of inserting foreign genes into the Drosophila genome involves P elements. The transposable P elements, also known ...
In protein synthesis, PKA first directly activates CREB, which binds the cAMP response element, altering the transcription and ... Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase was discovered by ... Cyclic+AMP-Dependent+Protein+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) ... The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts with catalytic subunit and an auto inhibitory ...
Bellamacina CR «The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins». FASEB J., 10, 11, 01 ... Cyclic ADP-Ribose and NAADP: Structure, Metabolism and Functions. Kluwer Academic Publishers, 2002. ISBN 1-40207-281-3. ... és un element clau en el fàrmac isoniazida, que és utilitzat en el tractament de la tuberculosi, una infecció causada pel ... AMP) al fosfat 5' d'un extrem del DNA. Aquest intermediari és seguidament atacat pel grup hidroxil 3' de l'altre extrem de DNA ...
The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger ... In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. ... "Modeling of the human middle ear using the finite-element method". The Journal of the Acoustical Society of America. 111 (3): ... Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a ...
... and adenyl cyclase converts AMP into cyclic AMP (cAMP) thereby down-regulating cAMP-responsive proteins involved in cell ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ... positive regulation of G-protein coupled receptor protein signaling pathway. • immune response. • neuropeptide signaling ... while arrestin-2 inhibits DP2 from further activating heterotrimeric G proteins while also linking DP2 to elements, clathrin ...
... nuclear located protein kinase C and cyclic AMP-dependent protein kinase". Frontiers in Bioscience. 13 (13): 1206-26. doi: ... In addition to serving as a primary component of cellular membranes and binding sites for intra- and intercellular proteins, ... Hunter JE (November 2006). "Dietary trans fatty acids: review of recent human studies and food industry responses". Lipids. 41 ... Protein-lipid interaction. *Phenolic lipid, a class of natural products composed of long aliphatic chains and phenolic rings ...
... cAMP Response Element-Binding) that will bind to the CRE (cAMP Responsive Element). However, this might not occur and, instead ... binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP ... TSH first binds to its receptors which are joined to G proteins, and then induces the activation of the enzyme adenylate ... This ingested iodine is bound to serum proteins, especially to albumins.[citation needed] The rest of the iodine which remains ...
a b c d e f g h i j Shi, Q., Karuppagounder, S. S., Xu, H., Pechman, D., Chen, H., and Gibson, G. E. (2007) Responses of the ... It is an 8 monomer that can be divided into 4 domains; the FAD-binding domain (residues 1-149), the NAD+-binding domain ( ... Cofactor TPP and AMP are shown in cyan and blue, respectively. [17] (B) Diagram of the 12 subunit catalytic core of the cubic ... Declining protein levels were the most evident for the E1k and E2k subunits, when compared to the control. On contrary, as the ...
... cAMP response element-binding protein) to DNA.[37] This reduction causes changes in the expression of critical immunoregulatory ... "Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally ... response to amphetamine. • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger. • ... immune response. • nociception. • inflammatory response. • negative regulation of inflammatory response. • signal transduction ...
As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP.[20] Cyclic AMP ... G-protein coupled receptor binding. • receptor binding. • protein N-terminus binding. Cellular component. • extracellular ... Secretin is released into circulation and/or intestinal lumen in response to low duodenal pH that ranges between 2 and 4.5 ... and the E-box element". Molecular Endocrinology. 18 (7): 1740-55. doi:10.1210/me.2003-0461. PMID 15118068.. ...
These proteins are called actin-binding proteins (ABP) and they are involved in actin's polymerization, depolymerization, ... Together these elements allow a spatially and temporally modulated assembly that defines a cell's response to both internal and ... "Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans". ... The most notable of these proteins are gelsolin and cofilin. These proteins first achieve a cut by binding to an actin monomer ...
The CREB protein binds to cAMP response elements CRE, and can either increase or decrease the transcription of certain genes. ... "Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system". ... This activates it, giving it the ability to catalyse substrate phosphorylation.[43] CREB (cAMP response element binding protein ... G proteins are specialised proteins whereby the nucleotides Guanosine diphosphate (GDP), and Guanosine triphosphate (GTP) bind ...
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... When cGMP binds to the allosteric GAF-B domain of the PDE, it causes conformational change in the protein structure leading to ... Furthermore, PDE2 has been indicated to play a role in inflammatory responses as it has been detected in microvessels, but not ... functional and structural elements of the active sites are very similar. The active site is formed by residues that are highly ...
The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger ... In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. ... Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a ... Koike, Takuji; Wada, Hiroshi; Kobayashi, Toshimitsu (2002). "Modeling of the human middle ear using the finite-element method ...
... "cyclic di-GMP" below). cyclic di-AMP riboswitches (also called ydaO/yuaA) bind the signaling molecule cyclic di-AMP. cyclic di- ... including protein-free binding assays, and metabolite-binding riboswitches were established as a new mechanism of gene ... The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the ... Cobalamin riboswitch (also B12-element), which binds either adenosylcobalamin (the coenzyme form of vitamin B12) or ...
... and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, ... or inhibiting adenylyl cyclase leading to the intracellular increase or decrease of the secondary messenger cyclic AMP. For ... the Gβγ complex associated with a mating factor receptor-coupled G protein in yeast was found to initiate a pheromone response ... The Gβγ complex is an essential element in the GPCR signaling cascade. It has two main states for which it performs different ...
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating Cys172 through ... binding protein, PABP. This disruption of this binding domain results in down regulation of the initiation of cap dependent ... P1 encodes for a proteins (VP1, VP2, VP3, and VP4) that make the capsid proteins. P2 and P3 proteins assist in infectivity of ...
... inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is ... The bacterium contains a surface protein, filamentous haemagglutinin adhesin, which binds to the sulfatides found on cilia of ... This is because B. pertussis inhibits the immune response, so very little mucus is generated in the lungs. A prolonged cough ... The primers used for PCR usually target the transposable elements IS481 and IS1001. Several diagnostic tests are available, ...
... but has no effect on protein kinase C or cyclic AMP-dependent kinase. Mutagenicity does not appear to occur for purified toxins ... When microcystin-LR binds directly to the catalytic center of the PPP enzymes, they block the access of the substrate to the ... These two variable elements are always standard L-amino acids. In microcystin-LR these are leucine and arginine. Eighty ... There is no change in the expression of selected genes involved in the cellular response to DNA damage after a 4-hour exposure ...
Keywords: vascular cognitive impairment, cAMP response element binding protein, cerebral ischamia, neuroprotection ... The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also ... Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of ... Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of ...
Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced ... Cyclic AMP Response Element-Binding Protein/immunology. *Cyclic AMP Response Element-Binding Protein/metabolism* ... We demonstrate cAMP response element (CRE)-binding activity in CNS protein extracts and show that one of the CRE-binding ... cyclic adenosine 3,5-monophosphate (cAMP) response element-binding protein (CREB) are conserved key steps in the molecular ...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... Cyclic AMP response element-binding protein H (CREBH) was identified as a liver-specific bZIP transcription factor [10, 11]. ... The cyclic AMP response element-binding protein H (CREBH) plays important roles in hepatic lipogenesis, fatty acid oxidation, ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ... acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H," ... cAMP responsive element-binding protein H)," Journal of Biological Chemistry, vol. 286, no. 49, pp. 41972-41984, 2011. View at ...
Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ...
Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ...
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ...
... report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements ( ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...
Cyclic AMP Response Element-Binding Protein*Cyclic AMP Response Element-Binding Protein ... "Cyclic AMP Response Element-Binding Protein" by people in this website by year, and whether "Cyclic AMP Response Element- ... Cyclic AMP Response Element Modulator. *Cyclic AMP Response Element-Binding Protein. *Cyclic AMP Response Element-Binding ... "Cyclic AMP Response Element-Binding Protein" is a descriptor in the National Library of Medicines controlled vocabulary ...
Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor- ... the neurogenic potential of EGb 761 and its effect on cAMP response element binding protein (CREB) were examined in a double ... The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to ... CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. ...
The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including interme … ... Cyclic AMP / physiology* * Cyclic AMP Response Element-Binding Protein / physiology * Cyclic AMP-Dependent Protein Kinases / ... owing in large part to the characterization of cyclic AMP-responsive promoter elements, transcription factors that bind them, ... The purpose of this review is to describe the components of the cyclic AMP response unit and to analyze how these components ...
A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... title = "A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol ...
Cyclic AMP Response Element-Binding Protein. Role of CREB in Axon Growth and Regeneration. During development, several ... axon growth by regulation of gene expression via the transcription factor cyclic AMP response element-binding protein (CREB; ... cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding ... and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by ...
Zhang R, Misra V. Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and ... Cyclic-Amp response element binding protein zhangfei (CREBZF) is a novel regulator of various cellular mechanisms such as ... Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal ... Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal ...
Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... stim ulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein ( ...
Cyclic AMP Response Element Binding Protein) ELISA Kit based in Delhi, India ... Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit ... Rat CHD3(Chromodomain Helicase DNA Binding Protein 3) ELISA Kit. *Rat CHD5(Chromodomain Helicase DNA Binding Protein 5) ELISA ... Rat MBP-C/MBL2(Mannma Binding Protein C/Mannan Binding Lectin 2) ELISA Kit ...
Genomic responses initiated by NMDA receptors (NMDARs) are critically dependent on whethe … ... Cyclic AMP Response Element-Binding Protein / metabolism* * Evoked Potentials * Hippocampus / growth & development* ... Genomic responses initiated by NMDA receptors (NMDARs) are critically dependent on whether synaptically or extrasynaptically ... Cyclic AMP Response Element-Binding Protein * Receptors, N-Methyl-D-Aspartate * Bicuculline ...
FIH, factor inhibiting HIF; CBP, cyclic AMP-response element binding protein; HRE, hypoxia response element ... However, in hypoxia, HIF-1α hydroxylation does not occur, stabilizing HIF-1 where it binds to a hypoxia response element ... Assuming an average cerebral tissue partial pressure of O2 (PcO2) of ~ 25 mmHg and lack of O2-binding proteins, the brains O2 ... As an element, oxygen (O) is unique; it is the third most abundant element in the universe after hydrogen and helium, the ...
Cyclic AMP response element-binding protein positively regulates production of IFN-γ by T cells in response to a microbial ... cyclic AMP response element binding protein (CREB), activating transcription factor (ATF)-2 and c-Jun bind to the IFN-γ ... culture filtrate protein of 10 kDa; CREB, cyclic AMP response element binding protein; RD, region of difference. ... Reduced expression of nuclear cyclic adenosine 5′-monophosphate response element-binding proteins and IFN-γ promoter function ...
Discovery of selective inhibitors for cyclic AMP response element-binding protein: a combined ligand and structure-based ... ABT-737 and erufosine combination against castration-resistant prostate cancer: a promising but cell-type specific response ...
cyclic AMP response element binding protein 73 ____ the co activator of CREB ... an example of a response element that binds to heat-specific transcription factors that are produced by elevated temperatures ... d. one transcription activator can bind to the same response element in multiple genes that each have unique promoters and ... a. consists of a single protein with two similar domains. b. Binding of TBP distorts DNA at TATA box. c. binding creates an 80 ...
Cyclic AMP Response Element-Binding Protein. *Culture Media, Conditioned. *Insulin-Like Growth Factor Binding Protein 1 ... G-protein coupled receptor activity - G-protein coupled receptor signaling pathway - Golgi membrane - hormone binding - ... The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5- ... Screening and Identification of a Phage Display Derived Peptide That Specifically Binds to the CD44 Protein Region Encoded by ...
cyclic AMP response element binding protein. **Received April 21, 1998.. *Accepted July 8, 1998. ... Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by ... cAMP-dependent protein kinase. CaMKII. Ca++/CaM-dependent protein kinase II. NADPH. β-nicotinamide dinucleotide phosphate. BH4 ... These results suggest that inhibition of nNOS activity is due to direct binding of the compound to thel-arginine binding site ...
0/Cyclic AMP Response Element-Binding Protein; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 0/SMN Complex Proteins; 0/SMN1 ... Cyclic AMP Response Element-Binding Protein / genetics*. Electromyography. Female. Forearm / innervation*. Genetic ... RNA-Binding Proteins / genetics*. SMN Complex Proteins. Spain. Spinal Cord / pathology. Survival of Motor Neuron 1 Protein. ... protein, human; 0/SMN2 protein, human; 0/Survival of Motor Neuron 1 Protein; 0/Survival of Motor Neuron 2 Protein ...
Cyclic AMP dependent transcription factor ATF 4 antibody. *Cyclic AMP response element binding protein 2 antibody ... Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular ... Protein - Recombinant Human ATF-4 protein (ab109946) SDS-PAGE Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P, WB, ... It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. ...
AP1, activator protein 1; CREB, cyclic AMP response element binding protein; NFκB, nuclear factor κB; NF-Y, nuclear factor Y.. ... Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y ... Cyclic AMP response element binding protein (CREB) TFBMs were significantly less prevalent in promoters of genes overexpressed ... Regulation of asthma-related T-cell cytokines by the cyclic AMP-dependent signalling pathway. Clin Exp Allergy 2000;30:920-6. ...
Cyclic AMP Response Element-Binding Protein. 2. 2011. 558. 0.480. Why? Bone Density Conservation Agents. 2. 2009. 718. 0.470. ... Insulin-Like Growth Factor Binding Protein 3. 2. 2009. 429. 0.120. Why? ...
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... The protein also has a magnesium ion that facilitates binding to DNA. The cAMP response element (CRE) is the response element ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ...
Cyclic AMP response element-binding protein prevents endothelial permeability.... Source: Frontiers in Pharmacology - April 24 ... Gene Ontology Analysis for Drug Targets of the Whole Genome Transcriptome of Human Vascular Endothelial Cells in Response to ... and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. Furthermore, a total of 104 ...
A promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Cyclic AMP Response Element. Known as: CRE, cAMP Response Element A promoter sequence which interacts with CRE binding proteins ... Genes regulated by cyclic AMP-response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell… ( ...
  • CREB phosphorylation involved c-Src-dependent extracellular signal-regulated kinase 1/2 activation, but not protein kinase A,prot ein kinase C,or calmodulin-dependent kinase II,and occurred also in cells transfected with AR or estrogen receptor mutants that do not localize into the nucleus. (unict.it)
  • SAP97 is the mammalian homolog of the Drosophila discs-large tumor suppressor and is a member of the MAGUK (membrane-associated guanylate kinase) family of proteins ( Sheng and Sala, 2001 ). (jneurosci.org)
  • A typical (albeit somewhat simplified) sequence of events is as follows: A signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a second messenger such as cAMP or Ca2+, which in turn activates a protein kinase. (wikipedia.org)
  • This protein kinase translocates to the cell nucleus, where it activates a CREB protein. (wikipedia.org)
  • Findings with a different protein, alpha-CaM kinase II, demonstrated the chemical's ability to erase both short-term and long-term fear memories in a very targeted fashion. (dana.org)
  • Joe Tsien and colleague conditioned fear in mice, and then successfully deleted the fear memories by overexpressing the protein alpha-CaM kinase II. (dana.org)
  • 2 During the embryonic stage, the animals were injected with a DNA molecule that caused their brains (when fully developed) to constantly overexpress a protein called alpha-CaM kinase II. (dana.org)
  • The first kinase identified as being responsible for the phosphorylation of serine 133 is a cAMP-dependent protein kinase (protein kinase A [PKA]), which is activated by an increase in the intracellular cAMP level. (ahajournals.org)
  • 15 This transcription factor is activated by phosphorylation of Ser133 residue, which is typically performed by protein kinase A. 16 However, other protein kinases such as extracellular signal-regulated kinases 1/2 (ERK1/2), p38 mitogen-activated protein kinase (p38MAPK), calmodulin kinase (CaMK), and protein kinase B (PKB) have also been shown to phosphorylate and activate CREB. (ahajournals.org)
  • Utilizing loss- and gain-of-function approaches in cultured epithelia and murine colonoids, we demonstrate that EA elicits prominent CREB phosphorylation through cyclic AMP-independent mechanisms that requires elements of the mitogen-activated protein kinase signaling pathway. (genengnews.com)
  • The solution structure of the complex formed by the phosphorylated kinase-inducible domain (pKID) of CREB with KIX reveals that pKID undergoes a coil-->helix folding transition upon binding to KIX, forming two alpha helices. (rcsb.org)
  • The cAMP-protein kinase A (PKA) pathway is an important intracellular signal transduction cascade that can be activated by a large variety of stimuli. (kuleuven.be)
  • One such transcription factor is the cAMP-regulatory element-binding protein (CREB), which can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, and calcium/calmodulin-dependent kinases and regulates genes whose deregulated expression promotes oncogenesis, including cyclins , Bcl-2 family members, and Egr-1 . (aacrjournals.org)
  • Signal transduction abnormalities in cancer mitogen-activated protein kinase regulation is altered in breast cancer. (jci.org)
  • Hyperexpression of mitogen-activated protein kinase in human breast cancer. (jci.org)
  • Mitogen-activated protein (MAP) kinases act as transducers of extracellular signaling via tyrosine kinase-growth factor receptors and G-protein-linked receptors to elements regulating transcription. (jci.org)
  • In spite of persistent activation via phosphorylation, MAP kinase expression is upregulated 5-20-fold and this hyperexpression may be a critical element to initiation as well as the metastatic potential of various forms of human breast cancer. (jci.org)
  • Selective interaction of JNK protein kinase isoforms with transcription factors. (nii.ac.jp)
  • In both phases, inhibition of cAMP-dependent protein kinase A (PKA) activity prevented ethanol-induced CRE-mediated luciferase expression. (aspetjournals.org)
  • 2015 ) protein kinase activates ATF2 (Bhoumik et al. (springer.com)
  • Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression. (springer.com)
  • Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. (nih.gov)
  • 1997) . DAG activates protein kinase C (PKC) (Riedel et al. (supermemo.com)
  • 1992b) that leads to increased levels of cAMP that migrates to the cell nucleus, activates protein kinase A (PKA) and triggers gene expression (Hagiwara et al. (supermemo.com)
  • NGF can drive the expression of genes such as bcl-2 by binding to the Tropomyosin receptor kinase A , which stimulates the proliferation and survival of the target neuron. (wikipedia.org)
  • Cyclic AMP-dependent protein kinases ( protein kinase A ) are activated by the signal chain coming from the G protein (that was activated by the LHCG-receptor) via adenylate cyclase and cyclic AMP (cAMP). (bionity.com)
  • The aim of this study was to determine if estrogens could directly modulate signalling pathways within bladder sensory neurons, such as extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases. (biomedcentral.com)
  • A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. (childrensmercy.org)
  • The following genes encode CREB or CREB-like proteins: CREB1 (CREB1) CREB2 renamed ATF4 (ATF4) CREB3 (CREB3) CREB5 (CREB5) CREB3L1 (CREB3L1) CREB3L2 (CREB3L2) CREB3L3 (CREB3L3) CREB3L4 (CREB3L4) CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases on the Serine 133 residue. (wikipedia.org)
  • Protein kinases and transcription factors transmit the signals from the external stimuli to the genome, resulting in the modification of gene expression profile of the cells to accommodate to the environmental changes. (ahajournals.org)
  • Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (reactome.org)
  • These protein kinases are present as tetramer with two regulatory units and two catalytic units. (bionity.com)
  • These proteins are typically activated through phosphorylation by the indicated upstream kinases. (pubmedcentralcanada.ca)
  • The promoter elements of many monocyte-specific genes contain C/EBP binding sites, including macrophage inflammatory protein 1 alpha, tumor necrosis factor alpha ( 32 ), IL-6 ( 6 , 27 , 38 ), and IL-8 ( 27 , 36 ). (asm.org)
  • Transcription of many genes is directed by the cAMP/Ca(2+)-responsive element (CRE) and its cognate transcription factor CRE-binding protein (CREB). (aspetjournals.org)
  • Sterol regulatory element-binding proteins (SREBPs) activate promoters for key genes of metabolism to keep pace with the cellular demand for lipids. (elsevier.com)
  • RNA pol II transcribes all protein coding, snoRNA and snRNA genes d. (brainscape.com)
  • Children with asthma from a low SES background showed overexpression of genes regulating inflammatory processes, including those involved in chemokine activity, stress responses and wound responses, compared with children with asthma from a high SES background. (bmj.com)
  • 11 12 Another social factor associated with low SES-stress-has been linked to heightened inflammatory responses to allergen challenge in patients with asthma, 13 and decreased expression of genes coding hormonal receptors that regulate inflammation, including the glucocorticoid and β adrenergic receptors. (bmj.com)
  • It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. (wikipedia.org)
  • The activated CREB protein then binds to a CRE region, and is then bound to by CBP (CREB-binding protein), which coactivates it, allowing it to switch certain genes on or off. (wikipedia.org)
  • Cyclic AMP regulates the expression of a number of genes through a conserved promoter element, the CRE1. (semanticscholar.org)
  • The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes. (wikipedia.org)
  • The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. (genecards.org)
  • Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. (genecards.org)
  • Processed cyclic AMP-responsive element-binding protein 3: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. (genecards.org)
  • CREB (cAMP response element-binding protein) [1] is a cellular transcription factor that binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. (wikiversity.org)
  • Within the cAMP-responsive element of the somatostatin gene, we observed an 8-base palindrome, 5'-TGACGTCA-3', which is highly conserved in many other genes whose expression is regulated by cAMP. (wikiversity.org)
  • Cells change the expression pattern of genes in response to extracellular signals. (ahajournals.org)
  • To obtain insights into the molecular mechanisms of this response a systematic genetic screen was performed to identify genes that when overexpressed can induce a starvation-like response in the yeast species Schizosaccharomyces pombe . (asm.org)
  • Thus, critical insight into the role of transcription factor activation in cancer arose from studying the regulation of genes in response to cytokines under normal conditions. (aacrjournals.org)
  • Previously, we used P -element mutagenesis and quantitative trait locus (QTL) mapping in Drosophila to identify candidate genes affecting resistance to starvation stress, and variation in resistance to starvation stress between the Oregon-R (Ore) and 2b strains. (biomedcentral.com)
  • Nearly 50% of P -element insertions in 160 genes with altered transcript abundance during starvation stress had mutational effects on starvation tolerance. (biomedcentral.com)
  • Typical enhancers of viral or cellular genes are approximately 100 to 400 bp long and contain several transcription factor binding sites. (asm.org)
  • We show here that ethanol exposure causes a striking increase in CRE- and CREB-mediated gene expression in cells transfected with luciferase reporter genes and that PKA and CREB are required for this response. (aspetjournals.org)
  • CREB triggers a gene expression cascade with a group of IEGs coding for transcription factors such as zif/268, c-fos, c-jun, junB, and junD that in turn lead to transcription of late effector genes coding for proteins critical for establishing long-term memory (Abraham et al. (supermemo.com)
  • These results suggest that, in addition to its role as a transcription factor for the expression of replication genes, Mcm1 may influence the local structure of replication origins by direct binding. (labome.org)
  • MicroRNAs originate from inter-and intragenic sites including introns of protein-coding genes and their own specific gene loci. (pubmedcentralcanada.ca)
  • DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE) which results in the activation of genes . (bionity.com)
  • NGF can drive the expression of genes such as bcl-2 by binding to the TrkA receptor , which stimulates the proliferation and survival of the target neuron. (wikipedia.org)
  • Alberini and M.D./Ph.D. student Stephen M. Taubenfeld suspected that CREB protein depends on certain consolidation-related genes from within the region of the brain known as the hippocampus (injuries to this area often result in amnesia). (brownalumnimagazine.com)
  • Next, she says, is figuring which genes the protein switches on. (brownalumnimagazine.com)
  • C/EBP proteins are all members of the b-ZIP family of transcription factors and share a highly homologous carboxy terminus that contains the basic and leucine zipper protein domains. (asm.org)
  • Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. (childrensmercy.org)
  • Our understanding of cyclic AMP signaling in the nucleus has expanded considerably over the past decade, owing in large part to the characterization of cyclic AMP-responsive promoter elements, transcription factors that bind them, and signal-dependent coactivators that mediate target gene induction. (nih.gov)
  • Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors. (ksdb.org)
  • ESAT-6 decreased IFN-γ transcription and reduced expression of the transcription factors, ATF-2 and c-Jun, which normally bind to the IFN-γ proximal promoter and stimulate mRNA expression. (jimmunol.org)
  • Nuclear factor-κB and activator protein 1 are relatively well-studied redox-sensitive transcription factors involved in the various aspects of the cardiovascular disease process. (ahajournals.org)
  • Although transcription factors have not been a central focus of drug development, recent advances suggest that CREB and other such proteins may be worthwhile targets for cancer therapy. (aacrjournals.org)
  • Since normal cells are relatively insensitive to inhibition of these proteins due to redundancies in normal signaling pathways, inhibitors of these transcription factors hold the potential for having a very high therapeutic index. (aacrjournals.org)
  • Hai T. The ATF transcription factors in cellular adaptive responses. (springer.com)
  • Hai T, Hartman MG. The molecular biology and nomenclature of the ATF/CREB family of transcription factors: ATF proteins and homeostasis. (springer.com)
  • Transcription factors 1: bZIP proteins. (springer.com)
  • These fragments contained, among other sites, binding sites for AP-1 and CREB transcription factors. (asm.org)
  • CCAAT/enhancer binding proteins (C/EBPs) are six-member family (α to ζ) of transcription factors. (nature.com)
  • AP1 proteins also dimerize efficiently with other transcription factors, including some that are not members of the bZIP family 193 . (pubmedcentralcanada.ca)
  • Hepatocyte nuclear factor 4 α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H," Hepatology , vol. 48, no. 4, pp. 1242-1250, 2008. (hindawi.com)
  • OBJECTIVE: The present study assessed the role of striatal CREB1 and its coactivator CREB-binding protein (CBP) in behavioural responses to psychostimulants. (isharonline.org)
  • Abnormalities of a protein that interacts with the KID domain of CREB, the CREB-binding protein, (CBP) is associated with Rubinstein-Taybi syndrome. (wikipedia.org)
  • 5 On phosphorylation at serine 133, the CREB binding protein (CBP) is recruited to CREB. (ahajournals.org)
  • Researchers led by Salvatore Oddo at the University of Texas in San Antonio found that plying Alzheimer's disease model mice with CREB binding protein (CBP) rescued learning in these mice without altering Aβ or tau levels. (alzforum.org)
  • Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). (genecards.org)
  • 5′-AMP is rapidly converted to adenosine (via surface-expressed CD73), and adenosine liberated in this fashion directly activates surface adenosine A 2B receptors ( 4 , 7 , 10 ) and promotes endothelial barrier function through elevation of intracellular cAMP ( 4 , 11 ). (jimmunol.org)
  • MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). (kegg.jp)
  • Upon binding LH externally to the membrane, a transduction of the signal takes place that activates the G protein that is bound to the receptor internally. (bionity.com)
  • With LH attached, the receptor shifts conformation and thus mechanically activates the G protein, which detaches from the receptor and activates the cAMP system. (bionity.com)
  • The phosphorylation and the binding to DNA of the nuclear transcription factor, cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) are conserved key steps in the molecular cascade leading to the formation of long-term memory (LTM). (nih.gov)
  • Adenosine-3',5'-cyclic monophosphate (cyclic AMP) is a second messenger that plays an important role in intracellular regulation. (biovendor.com)
  • [2] CREB was first described in 1987 as a cyclic adenosine monophosphate (cAMP)-responsive transcription factor regulating the somatostatin gene. (wikiversity.org)
  • During episodes of inflammation, multiple cell types release adenine nucleotides in the form of ATP, ADP, 5′-AMP, and adenosine. (jimmunol.org)
  • Extracellular 5′-AMP is metabolized to adenosine by surface-expressed 5′-ectonucleotidase (CD73). (jimmunol.org)
  • Initial experiments revealed that adenosine and adenosine analogues induce CD73 mRNA (RT-PCR), surface expression (immunoprecipitation of surface biotinylated CD73), and function (HPLC analysis of etheno-AMP conversion to ethenoadenosine) in a time- and concentration-dependent fashion. (jimmunol.org)
  • For instance, in epithelia and endothelia, cell surface CD73 converts AMP into adenosine, which when released can activate seven-transmembrane-spanning adenosine receptors ( 3 , 4 ) or can be internalized through dipyridamole-sensitive carriers ( 5 ). (jimmunol.org)
  • We have shown in the NG108-15 neuroblastoma × glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A 2 receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB). (aspetjournals.org)
  • The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism," Nature Medicine , vol. 17, no. 7, pp. 812-815, 2011. (hindawi.com)
  • Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H)," Journal of Biological Chemistry , vol. 286, no. 49, pp. 41972-41984, 2011. (hindawi.com)
  • The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including intermediary metabolism, cellular proliferation, and neuronal signaling, by altering basic patterns of gene expression. (nih.gov)
  • We now show that,in prostate cancer cells,stim ulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein (CREB) activation. (unict.it)
  • This protein binds to the cAMP-response element and regulates cell proliferation. (genecards.org)
  • Activating transcription factor 2 (ATF2) down-regulates hepatitis B virus X promoter activity by the competition for the activating protein 1 binding site and the formation of the ATF2-Jun heterodimer. (springer.com)
  • Thus, HIV-1 LTR ATF/CREB binding site sequence variation may modulate cellular signaling at the viral promoter through the C/EBP pathway. (asm.org)
  • The function of CREB can be modulated via a signalling pathway resulting from the binding of serotonin and noradrenaline to post-synaptic G-protein coupled receptors. (wikipedia.org)
  • The expression of mBDNF/TrkB/PI3K pathway-related proteins was detected by Western blot and quantitative reverse transcription-polymerase chain reaction (q-RT PCR). (dovepress.com)
  • Differences in transcriptional responses to the PKA pathway and other CREB-regulating stimuli between cells, tissues, and even organisms can be partially attributed to the presence of different CREB isoforms. (kuleuven.be)
  • MicroRNAs exert network-level effects on gene expression because each can target multiple transcripts that encode proteins in the same pathway or single targets in multiple pathways. (pubmedcentralcanada.ca)
  • Although transcriptional mechanisms responsible for these effects are not fully understood, it is recognized that transcriptional factor cAMP response element binding protein (CREB) mediates PTH signaling in osteoblasts, and that there is a communication between the PTH-CREB pathway and the BMP2 signaling pathway, which is important for osteoblast differentiation and bone formations. (nih.gov)
  • These findings, in conjunction with putative cAMP response elements (CREs) in the BMP2 promoter, led us to hypothesize that the PTH-CREB pathway could be a positive regulator of BMP2 transcription in osteoblasts. (nih.gov)
  • Analysis of DNA-binding activity by EMSA identified a functional role for CD73 cAMP response element and, moreover, indicated that multiple cAMP agonists induce transcriptional activation of functional CD73. (jimmunol.org)
  • cAMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1), members of the CREB/ATF family, have been implicated in cAMP- and calcium-induced transcriptional activation. (elsevier.com)
  • Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. (semanticscholar.org)
  • Activator protein 1 (AP1) 1 , 2 functions in almost all areas of eukaryotic cellular behaviour, from cell cycle proliferation and development to stress response and apoptosis. (pubmedcentralcanada.ca)
  • As the induction of apoptosis by diverse exogenous signals is dependent on the elevation of intracellular Ca 2+ , the purpose of this study was to determine the role of CREB and its associated proteins in apoptosis using KCREB. (elsevier.com)
  • Additionally, sequence variation at C/EBP site I, which lies immediately upstream of the distal nuclear factor kappa B site and immediately downstream of a binding site for activating transcription factor (ATF)/cyclic AMP response element binding protein (CREB), has been shown to affect HIV-1 long terminal repeat (LTR) activity. (asm.org)
  • CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. (wikipedia.org)
  • Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins located on human chromosome 2q32 and was discovered by Maekawa et al. (springer.com)
  • The mammalian AP1 proteins are homodimers and heterodimers composed of proteins from the Jun (JUN, JUNB and JUND) and Fos (FOS, FOSB, FRA1 and FRA2) families, and the closely related activating transcription factor (Atf and Creb) subfamily and the Maf subfamily 5 . (pubmedcentralcanada.ca)
  • Most importantly, sequence variation at the ATF/CREB binding site affected basal LTR activity as well as LTR function following interleukin-6 stimulation, a treatment that leads to increases in C/EBP activation. (asm.org)
  • We have used the chromatin immunoprecipitation (ChIP) technique coupled with a transient complementation assay in Drosophila SL2 cells to directly compare the ability of two members of the CREB/ATF family to function as co-regulatory proteins for SREBP-dependent activation of the HMG-CoA reductase promoter. (elsevier.com)
  • We evaluated the effects of ESAT-6 and its molecular chaperone, culture filtrate protein of 10 kDa (CFP10), on the capacity of human T cells to produce IFN-γ and proliferate in response to TCR activation. (jimmunol.org)
  • ESAT-6, but not CFP10, bound to T cells and inhibited expression of early activation markers without reducing activation of ZAP70. (jimmunol.org)
  • In particular, following activation, polymorphonuclear leukocytes release larger quantities of 5′-AMP. (jimmunol.org)
  • Ebrahimian T, Dierick F, Simon D, Heidari M, Orthwein A, Mann KK, Lehoux S. FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response. (harvard.edu)
  • HER-2/neu overexpression resulted in the induction and activation of CREB protein in vitro and in vivo , whereas short hairpin RNA (shRNA)-mediated inhibition of HER-2/neu correlated with downregulated CREB activity. (aacrjournals.org)
  • Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. (kegg.jp)
  • When the researchers looked directly at the hippocampus, they found that normal animals averaged a 152 percent increase in CREB protein activation, but CREB levels in the forgetful animals were flat. (brownalumnimagazine.com)
  • Recent observations have shown two CCAAT/enhancer binding protein (C/EBP) binding sites to be critically important for efficient human immunodeficiency virus type 1 (HIV-1) replication within cells of the monocyte/macrophage lineage, a cell type likely involved in transport of the virus to the brain. (asm.org)
  • Additional studies indicated that these two C/EBP binding sites were required for replication of an infectious HIV-1 molecular clone in the U-937 cell line as well as in primary cells of the monocyte/macrophage lineage. (asm.org)
  • While C/EBP proteins are expressed in many human tissues, high levels of C/EBP mRNA and protein expression are limited to only a few cell types, including cells of the myeloid lineage. (asm.org)
  • Some of these putative co-regulatory proteins are members of transcription factor families that all bind to the same DNA sequence elements in vitro and are often expressed in the same cells. (elsevier.com)
  • This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. (cancerindex.org)
  • Growth suppression of lung cancer cells by targeting cyclic AMP response element-binding protein. (semanticscholar.org)
  • We analyzed bioinformatics data and identified three TFs, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), cyclic AMP response element binding protein (CREB), and hypoxia-inducible factor-1α (HIF-1α), that are highly active in tumor cells. (biomedcentral.com)
  • Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH (2011) The role of colorectal cancer stem cells in metastatic disease and therapeutic response. (springer.com)
  • Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (FC epsilonRI) on the surface of mast cells with multivalent allergens results in the release of both pre-formed and newly generated mediators, and in the manifestation of allergic symptoms. (jci.org)
  • Kang Y, Chen CR, Massague J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. (springer.com)
  • Pinto M, Howell R. Concomitant quantification of targeted drug delivery and biological response in individual cells. (labome.org)
  • We had previously shown that the bLZip domain-containing transcription factor, Zhangfei/CREBZF inhibits the growth and the unfolded protein response (UPR) in cells of the D-17 canine osteosarcoma (OS) line and that the effects of Zhangfei are mediated by it stabilizing the tumour suppressor protein p53. (biomedcentral.com)
  • MicroRNAs function at a posttranscriptional level to fine-tune protein levels in cells. (pubmedcentralcanada.ca)
  • This has the effect of promoting degradation or inhibiting translational efficiency, leading to overall lower protein levels in cells ( 6 ). (pubmedcentralcanada.ca)
  • In rod cells, 11- cis -retinal binds to a protein called opsin to form the visual pigment rhodopsin (also known as visual purple). (oregonstate.edu)
  • The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1. (freepatentsonline.com)
  • We have previously demonstrated that quenching of CREB-associated proteins in metastatic melanoma cells by a dominant-negative CREB (KCREB) that is mutated within its DNA-binding decreased their radiation resistance, and their tumorigenic and metastatic potential in nude mice. (elsevier.com)
  • We did not observe any changes in Bcl-2 or Bcl-2-related proteins (Bcl-x, Bax, and Bad) in control or KCREB-transfected cells before or after treatment with Tg. (elsevier.com)
  • Collectively, these data indicate that CREB and its associated proteins act as survival factors for human melanoma cells, and hence contribute to the acquisition of the malignant phenotype. (elsevier.com)
  • A) ALP activity in C2C12 cells, treated with PTH at 0 to 200 nM for 24 hours, was measured with normalization by cell proteins. (nih.gov)
  • In addition, CREB-1 homodimers bind to the ATF/CREB site and recruit C/EBP dimers to their cognate weak binding sites. (asm.org)
  • The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. (bionity.com)
  • The different AP1 dimers bind to DNA with varying affinities and differ in their transactivation efficiencies 8 , 15 . (pubmedcentralcanada.ca)
  • Jun proteins can form stable dimers that bind to the AP1 DNA recognition element 5′-TGAC/GTCA-3′ (also known as TPA response element (TRE)) based on their ability to mediate transcriptional induction in response to the phorbol ester tumour promoter TPA 2 , 15 . (pubmedcentralcanada.ca)
  • Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced phosphorylation. (nih.gov)
  • To induce axon extension, the cellular machinery at the nerve growth cone controls the assembly of cytoskeletal proteins and membrane components into new axons. (frontiersin.org)
  • CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. (wikipedia.org)
  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. (wikipedia.org)
  • Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. (genecards.org)
  • Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. (genecards.org)
  • CREB was originally isolated as a gene regulatory protein that bound to the CRE site of the somatostatin gene promoter region in response to an increase in the cellular cAMP level. (ahajournals.org)
  • ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component? (springer.com)
  • The cyclic (c)AMP responsive element binding protein (CREB) plays a key role in many cellular processes, including differentiation, proliferation, and signal transduction. (aacrjournals.org)
  • These results indicate that SSRP1 is a novel cellular protein involved in LANA-dependent DNA replication. (labome.org)
  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. (uniprot.org)
  • Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus:5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. (hmdb.ca)
  • Their effects are particularly important for reducing "noise" and conferring precision to cellular protein levels, particularly for low-abundance targets ( 7 , 8 ). (pubmedcentralcanada.ca)
  • This inherently diverse composition of AP1 complexes and their central role in transcriptional regulation places AP1 complexes at a functional epicenter for pathological signal relay in disease, particularly in the context of malignant cellular transformation in which AP1 proteins are often deregulated by oncoprotein signalling 4 - 6 . (pubmedcentralcanada.ca)
  • Sequence analysis suggested that putative CREBH response element (CREBHRE) is located in the human APOA5 promoter region and is highly conserved in both human and rodent. (hindawi.com)
  • A promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in the cell. (semanticscholar.org)
  • Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding . (genecards.org)
  • Each species' promoter contains a cAMP/response element (CRE) 1 consensus sequence ( [7] ) upstream of a TATA box. (wikiversity.org)
  • fnx1 + encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins. (asm.org)
  • 1987 ). However, it was later found that, instead of a single polypeptide, many polypeptides can bind to the sequence (Hai et al. (springer.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription. (aspetjournals.org)
  • These results suggest that inhibition of nNOS activity is due to direct binding of the compound to the l -arginine binding site of the synthase. (aspetjournals.org)
  • In vitro studies showed that SVP conditioned medium stimulates endothelial tube formation and reduces myofibroblast differentiation, through inhibition of Ras-GTPase activating protein and methyl-CpG-binding protein 2, which are validated miR-132 targets. (ahajournals.org)
  • Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. (nih.gov)
  • After stable binding, other proteins may be recruited to the RISC, which promotes degradation or translational inhibition ( 13 ). (pubmedcentralcanada.ca)
  • In fact, C/EBP proteins are intimately involved in the regulation of myelocytic/monocytic gene expression. (asm.org)
  • Axon growth requires the coordinated regulation of gene expression in the neuronal soma, local protein translation in the axon, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. (frontiersin.org)
  • The results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation (p (cancerindex.org)
  • Addiction has been conceptualized as a cyclic process of impairment in self-regulation. (frontiersin.org)
  • Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. (semanticscholar.org)
  • Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP. (biovendor.com)
  • cAMP response element binding protein (CREB) has been implicated in the regulation of VSMC growth and motility in response to thrombin and angiotensin II. (ahajournals.org)
  • cAMP-response element-binding protein (CREB) belongs to the basic leucine-zipper family of transcriptional factors that were shown to play an important role in gene regulation, particularly in response to cAMP. (ahajournals.org)
  • This review will mainly focus on the presence and regulation of CREB proteins in insects. (kuleuven.be)
  • Here, we characterize, for the first time, a CREB1-like protein in the central nervous system (CNS) of Lymnaea, a model system used widely for the study of the fundamental mechanisms of learning and memory. (nih.gov)
  • We demonstrate cAMP response element (CRE)-binding activity in CNS protein extracts and show that one of the CRE-binding proteins is recognized by a polyclonal antibody raised to mammalian (human) CREB1. (nih.gov)
  • Moreover, phospho-CREB1-specific immunoreactivity is increased significantly in protein extracts of the CNS by forskolin, an activator of adenylate cyclase. (nih.gov)
  • Significantly, classical food-reward conditioning increases phospho-CREB1 immunoreactivity in Lymnaea CNS protein extracts. (nih.gov)
  • This work establishes the expression of a highly conserved functional CREB1-like protein in the CNS of Lymnaea and opens the way for a detailed analysis of the role of CREB proteins in LTM formation in this model system. (nih.gov)
  • RATIONALE: The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. (isharonline.org)
  • In response to drug exposure, CREB1 is phosphorylated in the striatum, a structure that is critically involved in reward-related learning. (isharonline.org)
  • The binding of LH (or CG) to the receptor shifts the equilibrium between active and inactive receptors. (bionity.com)
  • Kerppola TK, Curran T. Selective DNA bending by a variety of bZIP proteins. (childrensmercy.org)
  • Moreover, it was shown that CREBH directly regulated human APOA5 gene expression by binding to a unique CREBHRE located in the proximal human APOA5 promoter region, using 5′-deletion and mutagenesis of human APOA5 promoter analysis and chromatin immunoprecipitation assay. (hindawi.com)
  • CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression," Nucleic Acids Research , vol. 29, no. 10, pp. 2154-2162, 2001. (hindawi.com)
  • Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. (semanticscholar.org)
  • SMA is caused by a mutation of the survival-of-motor-neuron 1 (SMN1) gene, leading to a quantitative defect in the survival-motor-neuron (SMN) protein expression. (isharonline.org)
  • The purpose of this review is to describe the components of the cyclic AMP response unit and to analyze how these components cooperate to induce target gene expression in response to hormonal stimulation. (nih.gov)
  • Confocal imaging analysis indicated that the protein expression of CREBZF in seminiferous tubule remained low until postnatal day (PD) 14, and was dramatically increased in PD 21. (ksdb.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. (cancerindex.org)
  • Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. (genecards.org)
  • Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression. (genecards.org)
  • CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. (wikiversity.org)
  • Serial 5′ deletions and site-directed mutagenesis of IL-6 promoter along with chromatin immunoprecipitation using anti-CREB antibodies showed that cAMP response element is essential for 15(S)-HETE-induced IL-6 expression. (ahajournals.org)
  • Adenovirus-mediated transduction of 15-lipoxygenase 2 (15-LOX2) caused increased production of 15-HETE in VSMCs and enhanced IL-6 expression, SMC migration from media to intimal region, and neointima formation in response to arterial injury. (ahajournals.org)
  • Reverse transcription polymerase chain reaction, western blotting and cell transfection were applied for the measurement of mRNA, protein expression and activity. (biomedcentral.com)
  • Adaptive responses, including changes in gene expression in neurons, are thought to account for some of these complex behavioral abnormalities. (aspetjournals.org)
  • However, phosphorylation of CREB is not sufficient to activate cAMP response element (CRE)-mediated gene expression. (aspetjournals.org)
  • Coexpression of a dominant-negative CREB construct blocked ethanol-stimulated CRE-luciferase expression, further suggesting that CREB is required for this response. (aspetjournals.org)
  • Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. (usf.edu)
  • To establish a mechanistic link between HER-2/neu-mediated transformation and CREB protein expression and function, in vitro models of HER-2/neu-overexpressing and HER-2/neu-negative/silenced counterparts as well as human mammary carcinoma lesions with defined HER-2/neu status were used. (aacrjournals.org)
  • Expression profiling in ALL: We are examining gene expression profiles in acute lymphoblastic leukemia in response to chemotherapeutic agents. (stanford.edu)
  • Guo Y, Breeden L, Zarbl H, Preston B, Eaton D. Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. (labome.org)
  • The CCAAT enhancer binding protein beta (C/EBP-β) increased the expression of miR-16 after I/R injury. (nature.com)
  • The ChIP and luciferase promoter assay indicated that about −1.0 kb to −0.5 kb upstream of miR-16 genome promoter region containing C/EBP-β binding motif transcriptionally regulated miR-16 expression. (nature.com)
  • No studies investigating the function of C/EBP-β in the kidney have been reported except for the ER stress induced renal C/EBP-β and the suppression of NF-κB-dependent gene expression in response to LPS in mice 17 . (nature.com)
  • T0901317, a synthetic LXR ligand, decreased AT1R mRNA and protein expression with a peak reduction at 6 hours and 12 hours of incubation, respectively. (ahajournals.org)
  • 3,4 Expression of these ABC proteins is increased by LXR agonists. (ahajournals.org)
  • We tested the hypothesis that queen mandibular pheromone (QMP) causes changes in gene expression in the brain of the adult worker honey bee, and that these changes can be correlated to the downstream behavioral responses induced by QMP. (pnas.org)
  • The dimeric combinations and transcriptional activity observed in vivo are largely influenced by the tissue-specific expression patterns of the individual proteins, and importantly by their specific activating mechanisms and post-translational modifications that facilitate their individual ability to dimerize with other basic leucine zipper (bZIP) domain proteins. (pubmedcentralcanada.ca)
  • 20. The expression system of claim 1, wherein the neuron-specific regulatory element is the synapsin promoter as set forth in FIG. 8 beginning at position 7 and ending at position 488. (freepatentsonline.com)
  • Radioreceptor binding assays and gene expression was done in the cerebral cortex and cerebellum of male Wistar rats using specific ligands and probes. (biomedcentral.com)
  • All of these beneficial effects are associated with an induction of intracellular cAMP levels and phosphorylated cAMP response element-binding protein expression in nucleus, which both attenuated by adenine 9-β-d-arabinofuranoside, an adenylate cyclase inhibitor. (elsevier.com)
  • An unusual result was that the conserved nucleotide at position 6 did not significantly affect in vitro binding of the complex. (labome.org)
  • X. Prieur, H. Coste, and J. C. Rodríguez, "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor- α and contains a novel farnesoid X-activated receptor response element," Journal of Biological Chemistry , vol. 278, no. 28, pp. 25468-25480, 2003. (hindawi.com)
  • Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor/cyclic AMP mechanism. (aspetjournals.org)
  • This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. (cancerindex.org)
  • Ultrasound-targeted microbubble destruction of calcium channel subunit α 1D siRNA inhibits breast cancer via G protein-coupled receptor 30. (cancerindex.org)
  • Further analysis revealed that EA signals through the G protein-coupled receptor GPR31 to promote induction of FosB, NR4A1, and DUSP1. (genengnews.com)
  • Allegra CJ, Rumble RB, Hamilton SR, Mangu PB, Roach N, Hantel A, Schilsky RL (2016) Extended RAS gene mutation testing in metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy: American Society of Clinical Oncology provisional clinical opinion update 2015. (springer.com)
  • microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia. (springer.com)
  • Survival occurs when recruited cytoplasmic adaptor proteins facilitate signal transduction through tumor necrosis factor receptor members such as TRAF6 , which results in the release of nuclear factor κB ( NF-κB ) transcription activator. (wikipedia.org)
  • The luteinizing hormone/choriogonadotropin receptor ( LHCGR ), also lutropin/choriogonadotropin receptor ( LCGR ) is a transmembrane receptor that interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). (bionity.com)
  • Total dopaminergic receptor binding parameter, B max showed an increase in cerebral cortex and decrease in the cerebellum of diabetic rats. (biomedcentral.com)
  • Here we report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome. (semanticscholar.org)
  • Other research demonstrated that the protein CREB can help pinpoint the neurons linked to a particular memory. (dana.org)
  • The C/EBP family of proteins includes at least eight different proteins, many of which are important activators of transcription. (asm.org)
  • 2018 ). Thus, we can thank our (dying) lucky stars, the burning crucibles that convert hydrogen and helium into heavier elements for our O 2 , the molecule that made our world, our brains and us. (springer.com)
  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. (genecards.org)
  • Moreover, microRNA-132 (miR-132) was constitutively expressed and secreted by SVPs and remarkably upregulated, together with its transcriptional activator cyclic AMP response element-binding protein, on stimulation by H/S or vascular endothelial growth factor B. We next investigated if SVP-secreted miR-132 acts as a paracrine activator of cardiac healing. (ahajournals.org)
  • In the present study the effects of NE on the phosphorylation of the cAMP response element-binding protein (CREB) were studied to determine whether CREB phosphorylation might be involved in cAMP signal transduction in this tissue. (aspetjournals.org)
  • The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. (cancerindex.org)
  • The diagram shows an overview of the four core promoter elements B recognition element (BRE), TATA box , initiator element (Inr), and downstream promoter element (DPE), with their respective consensus sequences and their distance from the transcription start site . (wikiversity.org)
  • Vaccine development hinges on understanding the molecular mechanisms of the host-pathogen interaction, particularly those that affect T cell responses, because this is believed to be pivotal for controlling M. tuberculosis infection. (jimmunol.org)
  • By the mid-1990s, studies had already suggested a basic difference in the molecular mechanisms of short-term versus long-term memories: The latter required new protein synthesis, while the former did not. (dana.org)
  • Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. (wikipedia.org)
  • cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. (wikipedia.org)
  • CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. (genecards.org)
  • The DNA binding of CREB is mediated via its basic leucine zipper domain (bZIP domain) as depicted in the image. (wikipedia.org)
  • Since CREB is a basic leucine zipper (bZip) protein, other insect members of this important family of transcriptional regulators will be briefly discussed as well. (kuleuven.be)
  • AP1 constituent proteins are structurally distinguished by a basic leucine zipper (bZIP) domain that is composed of leucine zipper and basic domains. (pubmedcentralcanada.ca)
  • Two other members of this family of proteins, chromogranin B and secretogranin II (also known as chromogranin C), contain similar CRE and TATA homologies in their proximal gene promoters (8, 9). (wikiversity.org)
  • The term ATF was first used in 1987 to refer to a putative polypeptide with the activity to bind to the sites on the adenovirus E2, E3, and E4 promoters with sequences similar to the consensus TGACGT(C/A)(G/A) (Lee et al. (springer.com)
  • Like D-17, the three cell lines expressed p53 proteins that were capable of activating promoters with p53 response elements on their own, and synergistically with Zhangfei. (biomedcentral.com)
  • 1989 ). The ATF2 protein consists of 505 amino acids, with phosphorylation sites near the C-terminus at serine residues 472 and 480 in the mouse protein and serine residues 490 and 498 in the human protein. (springer.com)
  • The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating the protein into functional NGF. (wikipedia.org)
  • 1989 ). These proteins were collectively called the ATF family of proteins. (springer.com)
  • The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009) CAMP responsive element modulator has been shown to interact with FHL5. (wikipedia.org)
  • In this study, we observed the existence of a putative "megaplasmid," multiple copies of ribosomal RNA operons, and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. (medworm.com)
  • This chapter makes a journey about CMS2 tumour characterization, their conventional treatment, and how modulation of Wnt signalling or immune response may be applied to CRC therapy. (springer.com)
  • bZIP contains the basic region and the leucine zipper important for DNA binding and dimerization, respectively. (ahajournals.org)
  • One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity. (springer.com)
  • Transcriptional activators include C/EBP α ( 4 ), C/EBP β (nuclear factor interleukin-6), (IL-6) ( 2 , 9 , 12 , 40 ), C/EBP δ ( 42 ), C/EBP ɛ ( 44 ), and C/EBP-related protein 1 (CRP-1) ( 42 ). (asm.org)
  • Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y and increased nuclear factor κB transcriptional signalling mediated these effects. (bmj.com)
  • The cAMP response element binding protein (CREB) is a ubiquitously expressed nuclear transcription factor that is activated by various extracellular stimuli. (ahajournals.org)
  • The cAMP response element (CRE) binding protein (CREB) is a nuclear transcription factor and is ubiquitously expressed. (ahajournals.org)
  • In vertebrates, the best-characterized nuclear targets of PKA are the cyclic AMP response element-binding (CREB) proteins. (kuleuven.be)
  • Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism. (semanticscholar.org)
  • We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70. (jimmunol.org)
  • Downstream elements d. (brainscape.com)
  • A partial cross is observed against CREM-1 protein. (alzforum.org)
  • The CREM bound to the -180 site of the IL-2 promoter to repress its transcription. (wikipedia.org)
  • Cyclic AMP Response Element-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Hannila SS, Filbin MT. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. (biovendor.com)
  • The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also pivotal in the switch from short-term to long-term memory. (dovepress.com)
  • CREB was detected using gel mobility-shift analysis with the radiolabeled Ca2+/cAMP response element of the c-fos promoter. (aspetjournals.org)
  • The cloned CD73 gene promoter bears a cAMP response element (CRE) 3 ( 12 ), which is one of the consensus DNA motifs that regulate transcription through the cAMP-dependent coactivator CRE binding protein (CREB) ( 13 ). (jimmunol.org)
  • Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins leading to the physiologic action. (bionity.com)
  • The primary function attributed to endothelial CD73 has been catabolism of extracellular nucleotides, although CD73 may also mediate lymphocyte binding under some circumstances ( 8 ). (jimmunol.org)
  • Moreover, a recent study showed that CREBH could bind to its unique response element (CREBHRE) in the target gene promoter to modulate transcription [ 10 , 12 ]. (hindawi.com)
  • Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of alcoholism. (isharonline.org)