Cyclic amp response element binding protein a. Medical search

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.

A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.

Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.

A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.

A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

Established cell cultures that have the potential to propagate indefinitely.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

Nucleic acid sequences involved in regulating the expression of genes.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.

Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.

A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. (1/16)

In this report, we describe the isolation and initial characterization of a Drosophila protein, dCREB-A, that can bind the somatostatin cyclic AMP (cAMP)-responsive element and is capable of activating transcription in cell culture. Sequence analysis demonstrates that this protein is a member of the leucine zipper family of transcription factors. dCREB-A is unusual in that it contains six hydrophobic residue iterations in the zipper domain rather than the four or five commonly found in this group of proteins. The DNA-binding domain is more closely related to mammalian CREB than to the AP-1 factors in both sequence homology and specificity of cAMP-responsive element binding. In embryos, dCREB-A is expressed in the developing salivary gland. A more complex pattern of expression is detected in the adult; transcripts are found in the brain and optic lobe cell bodies, salivary gland, and midgut epithelial cells of the cardia. In females, dCREB-A is expressed in the ovarian columnar follicle cells, and in males, dCREB-A RNA is seen in the seminal vesicle, ejaculatory duct, and ejaculatory bulb. These results suggest that the dCREB-A transcription factor may be involved in fertility and neurological functions. (+info)

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (2/16)

We have identified a Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes. DNA sequence analysis of cDNA clones encoding this protein, box B-binding factor-2 (BBF-2), indicates that it is a member of the CREB/ATF family of transcriptional regulatory proteins. A number of observations suggest that BBF-2 is involved in fat body-specific expression: Mutations that disrupt BBF-2 binding to two different Adh fat body enhancers in vitro decrease the activity of these enhancers in transgenic flies. BBF-2 mRNA is present in all cell types examined, and the protein is present in cells that express ADH. Finally, BBF-2 is a transcriptional activator in Drosophila tissue culture cells. Remarkably, BBF-2 also binds specifically to regulatory elements required for liver-specific expression of the human Adh and rat tyrosine aminotransferase genes. Thus, BBF-2 and the DNA sequence to which it binds may be important components of a tissue-specific regulatory mechanism conserved between Drosophila and man. (+info)

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. (3/16)

Understanding how organs acquire the capacity to perform their respective functions is important for both cell and developmental biology. Here, we have examined the role of early-expressed transcription factors in activating genes crucial for secretory function in the Drosophila salivary gland. We show that expression of genes encoding proteins required for ER targeting and translocation, and proteins that mediate transport between the ER and Golgi is very high in the early salivary gland. This high level expression requires two early salivary gland transcription factors; CrebA is required throughout embryogenesis and Fkh is required only during late embryonic stages. As Fkh is required to maintain late CrebA expression in the salivary gland, Fkh probably works through CrebA to affect secretory pathway gene expression. In support of these regulatory interactions, we show that CrebA is important for elevated secretion in the salivary gland. Additionally, CrebA is required for the expression of the secretory pathway genes in the embryonic epidermis, where CrebA had previously been shown to be essential for cuticle development. We show that zygotic mutations in several individual secretory pathway genes result in larval cuticle phenotypes nearly identical to those of CrebA mutants. Thus, CrebA activity is linked to secretory function in multiple tissues. (+info)

Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. (4/16)

(Fkh) is required to block salivary gland apoptosis, internalize salivary gland precursors, prevent expression of duct genes in secretory cells and maintain expression of CrebA, which is required for elevated secretory function. Here, we characterize two new Fkh-dependent genes: PH4alphaSG1 and PH4alphaSG2. We show through in vitro DNA-binding studies and in vivo expression assays that Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1. PH4alphaSG1 and PH4alphaSG2 encode alpha-subunits of resident ER enzymes that hydroxylate prolines in collagen and other secreted proteins. We demonstrate that salivary gland secretions are altered in embryos missing function of PH4alphaSG1 and PH4alphaSG2; secretory content is reduced and shows increased electron density by TEM. Interestingly, the altered secretory content results in regions of tube dilation and constriction, with intermittent tube closure. The regulation studies and phenotypic characterization of PH4alphaSG1 and PH4alphaSG2 link Fkh, which initiates tube formation, to the maintenance of an open and uniformly sized secretory tube. (+info)

Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2. (5/16)

Direct bacterial conversion of the hemicellulose fraction of hardwoods and crop residues to biobased products depends upon extracellular depolymerization of methylglucuronoxylan (MeGAX(n)), followed by assimilation and intracellular conversion of aldouronates and xylooligosaccharides to fermentable xylose. Paenibacillus sp. strain JDR-2, an aggressively xylanolytic bacterium, secretes a multimodular cell-associated GH10 endoxylanase (XynA1) that catalyzes depolymerization of MeGAX(n) and rapidly assimilates the principal products, beta-1,4-xylobiose, beta-1,4-xylotriose, and MeGAX(3), the aldotetrauronate 4-O-methylglucuronosyl-alpha-1,2-xylotriose. Genomic libraries derived from this bacterium have now allowed cloning and sequencing of a unique aldouronate utilization gene cluster comprised of genes encoding signal transduction regulatory proteins, ABC transporter proteins, and the enzymes AguA (GH67 alpha-glucuronidase), XynA2 (GH10 endoxylanase), and XynB (GH43 beta-xylosidase/alpha-arabinofuranosidase). Expression of these genes, as well as xynA1 encoding the secreted GH10 endoxylanase, is induced by growth on MeGAX(n) and repressed by glucose. Sequences in the yesN, lplA, and xynA2 genes within the cluster and in the distal xynA1 gene show significant similarity to catabolite responsive element (cre) defined in Bacillus subtilis for recognition of the catabolite control protein (CcpA) and consequential repression of catabolic regulons. The aldouronate utilization gene cluster in Paenibacillus sp. strain JDR-2 operates as a regulon, coregulated with the expression of xynA1, conferring the ability for efficient assimilation and catabolism of the aldouronate product generated by a multimodular cell surface-anchored GH10 endoxylanase. This cluster offers a desirable metabolic potential for bacterial conversion of hemicellulose fractions of hardwood and crop residues to biobased products. (+info)

Identification and analysis of two splice variants of human G2A generated by alternative splicing. (6/16)

(+info)

The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. (7/16)

(+info)

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (8/16)

(+info)

January 2012). "Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein ... This precursor protein also includes the oxytocin carrier protein neurophysin I. The inactive precursor protein is ... Oxytocin modulates fear responses by enhancing the maintenance of social memories. Rats that are genetically modified to have a ... In the pituitary gland, oxytocin is packaged in large, dense-core vesicles, where it is bound to neurophysin I as shown in the ...

https://en.wikipedia.org/wiki/Oxytocin

Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... The protein also has a magnesium ion that facilitates binding to DNA. The cAMP response element (CRE) is the response element ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ...

https://en.wikipedia.org/wiki/CREB

Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB ...

https://en.wikipedia.org/wiki/CAMP_responsive_element_modulator

Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ... Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ...

https://en.wikipedia.org/wiki/RELA

The structure of cyclic-AMP response element binding protein (CBP) and E1A complex was determined by NMR. It reveals that CR1 ... Early proteins typically encode non-structural proteins that are necessary for replication, whereas late structural proteins ... "The structure of the site on adenovirus early region 1A responsible for binding to TATA-binding protein determined by NMR ... The fixed structure allows this domain to recognize TATA-binding protein (TBP) and activate transcription of certain genes. The ...

https://en.wikipedia.org/wiki/Adenovirus_early_region_1A

Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (1990). "A cDNA for a human cyclic AMP response element-binding protein which is ... "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain". EMBO J. 8 (7): 2023-8. ... "Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32". Genomics. 11 ...

https://en.wikipedia.org/wiki/Activating_transcription_factor_2

"ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF ... These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate ... The presence of heavy glycosylation and other structural characteristics of ICAM-1 lend the protein binding sites for numerous ... ICAM-1 possesses binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 ...

https://en.wikipedia.org/wiki/ICAM-1

GSK-3β inhibits the transcription factors β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by ... Lithium was found to increase the basal levels of cyclic AMP but impair receptor coupled stimulation of cyclic AMP production. ... It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP production ... Over a long period of lithium treatment, cyclic AMP and adenylate cyclase levels are further changed by gene transcription ...

https://en.wikipedia.org/wiki/Lithium_(medication)

Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later ...

https://en.wikipedia.org/wiki/Transcription_factor_Jun

Lee JA, Kim H, Lee YS, Kaang BK (2003). "Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein- ... "AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic ... transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element-binding protein (CREB). ... he found that multiple pulses of serotonin stimulate gene expression that is mediated by the cAMP-response element (CRE). He ...

https://en.wikipedia.org/wiki/Kaang_Bong-kiun

... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor. Phosphorylated CREB ... Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. ... This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf. Raf in turn activates the ...

https://en.wikipedia.org/wiki/Nerve_growth_factor

... action potentials have been shown to induce BDNF-dependent phosphorylation of cyclic AMP response element-binding protein (CREB ... This change also affects future integration of signals, leading to at least a short-term response difference between the ... boosting synaptic responses, resetting membrane potential, retrograde actions at synapses and conditional axonal output. ...

https://en.wikipedia.org/wiki/Neural_backpropagation

Cyclic-AMP response element-binding protein (CREB), which is thought to be involved in GDNF regulation, associates with the ... cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein ... CREB Binding Protein. Therefore, this antidepressant, by increasing acetylation, works to lessen the HPA response, and as a ... It is thought that this is happening due to an interaction between the response element of GR and the acetyltransferase, ...

https://en.wikipedia.org/wiki/Epigenetics_of_depression

... calmodulin-dependent protein kinase II (CaMKII) or cyclic-AMP response element binding protein (CREB). In these mice, ... Stimulation of multiple whiskers may produce a response that is equal to the sum of the responses if each whisker was ... In deprived cortex, neuronal responses to spared whiskers are enhanced and responses to deprived whiskers are weakened. These ... with the weakening of deprived response preceding the strengthening of spared response, implying that they have different ...

https://en.wikipedia.org/wiki/Barrel_cortex

Cyclic AMP-response Element Binding (protein) CREEP - (a) Committee for the Re-Election of the President, a pejorative nickname ... Cyclic Code Shift Keying CCT - (i) Current Commitments Team CCTT - (i) Close Combat Tactical Trainer cd - (s) Candela Cd - (s) ... Computer Emergency Response Team ces - (s) Czech language (ISO 639-2 code) CESS - (i) Centre for Earth Science Studies (India) ... from the chemical symbols of the two component elements) CUW - (s) Curaçao (ISO 3166 trigram) cv - (s) Chuvash language (ISO ...

https://en.wikipedia.org/wiki/List_of_acronyms:_C

DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ... Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins, ...

https://en.wikipedia.org/wiki/Follicle-stimulating_hormone_receptor

Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ... cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. Alcohol Clin Exp ...

https://en.wikipedia.org/wiki/Molecular_and_epigenetic_mechanisms_of_alcoholism

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. The product of this ... cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... "Entrez Gene: CREB5 cAMP responsive element binding protein 5". Cumulated Index Medicus. U.S. Department of Health and Human ...

https://en.wikipedia.org/wiki/CREB5

7 kb upstream that contains binding sites for cyclic AMP response element-binding protein (CREB), myocyte enhancer factor 2 ( ... a serum response element (SRE; see serum response factor) at ~1.5 kb upstream of the initiation site. a second SRE at ~6.5 kb; ... The common factor for these signaling molecules involves activation of cyclic-AMP and its downstream target protein kinase A ( ... Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively. ...

https://en.wikipedia.org/wiki/Activity-regulated_cytoskeleton-associated_protein

... protein kinase A (PKA) is activated and phosphorylates the transcription factor cAMP Response Element Binding (CREB) protein. ... This ligand binding causes the activation of adenylate cyclase, which causes the creation of cyclic AMP (cAMP). As the ... Somatostatin inhibits glucagon secretion through the activation of SSTR2, a membrane bound protein that when activated causes a ... This protein channel allows zinc to cross the plasma membrane into the cell. When ZnT8 is under-expressed, there is a marked ...

https://en.wikipedia.org/wiki/Alpha_cell

... and progesterone response element. Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent ... N-terminal structure that secures the binding of fructose-6-phosphate to the active site via interaction with the protein's '2- ... The promoter of PFKFB3 contains binding sites, called hypoxia response elements (HREs), that recruit the binding of hypoxia- ... The PFKFB3 promoter is predicted to contain multiple binding sites, including Sp-1 and AP-2 binding sites. It also contains ...

https://en.wikipedia.org/wiki/PFKFB3

Specifically, estrogen increased cAMP activity and cAMP response element-binding protein phosphorylation in neuroblastoma cells ... modulated by estrogen in both human SK-N-SH neuroblastoma cell cultures as well as in mice through interactions with cyclic AMP ... Additionally, neurotensin gene transcription was blocked in knock-out mice lacking the RIIβ subunit of the protein kinase A ... Neurotensin is synthesized as part of a 169 or 170 amino acid precursor protein that also contains the related neuropeptide ...

https://en.wikipedia.org/wiki/Neurotensin

Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ... is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on ...

https://en.wikipedia.org/wiki/CREB1

Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ... Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A." J. ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ...

https://en.wikipedia.org/wiki/ATF1

Lastly, several "cyclic AMP response elements" with sequence TGACGTCA that binds CREB. In humans, a "Z-element" resides 243-292 ... each of which serve as binding sites for distinct regulatory proteins. First, multiple A/T-rich sequences, called "A elements ... These regions are primarily bound by PDX-1, but also Cdx2 and Isl-1. Second, two so-called "C elements" - C1 located 107-118 ... C2 (also called the "pancreatic islet cell enhancer sequence" or "PISCES") is bound by PAX6. Third, an "E element" (two in ...

https://en.wikipedia.org/wiki/Insulin_regulatory_sequence

... cyclic AMP responsive element-binding protein) in this process. Certain synapses on recruited neurons are more likely to ... The transcription factor cAMP response element-binding protein (CREB) is a well-studied mechanism of neuronal memory allocation ... Nguyen, P. V., & Woo, N. H. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...

https://en.wikipedia.org/wiki/Neuronal_memory_allocation

Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (1999). "The cyclic AMP response element ... CBX5m TATA binding protein, and Transcription initiation protein SPT3 homolog. Yeast TFIID comprises the TATA binding protein ... and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ...

https://en.wikipedia.org/wiki/TAF4

Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The ... These receptors generally function via intracellular second messengers, including cyclic AMP (cAMP), cyclic GMP (cGMP), ... The features of G proteins include GDP/GTP binding, GTP hydrolysis and guanosine nucleotide exchange. When a ligand binds to a ... Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. Because of the relatively ...

https://en.wikipedia.org/wiki/Hormone_receptor

... and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)". Cancer Research. 62 (12): 3428- ... He was among the pioneers to implicate the unfolded protein response (UPR) in acquired endocrine resistance and in regulating ... the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate". Cancer Research. 72 (6): ... "Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible ...

https://en.wikipedia.org/wiki/Robert_Clarke_(academic)

"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this ... In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ...

https://en.wikipedia.org/wiki/CEBPB

The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ... Calcium first binds to calmodulin to form CaM. CaM will then bind to the CNG channel and close it, stopping the sodium and ... The effect of this negative feedback response inhibits the neuron from further activation when another odor molecule is ... AC with 0 elements, Chemoreceptor cells, Olfactory system, Neurons, Signal transduction). ...

https://en.wikipedia.org/wiki/Olfactory_receptor_neuron

The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger ... In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. ... Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a ... Koike, Takuji; Wada, Hiroshi; Kobayashi, Toshimitsu (2002). "Modeling of the human middle ear using the finite-element method ...

https://en.wikipedia.org/wiki/Transduction_(physiology)

... "cyclic di-GMP" below). cyclic di-AMP riboswitches (also called ydaO/yuaA) bind the signaling molecule cyclic di-AMP. cyclic di- ... including protein-free binding assays, and metabolite-binding riboswitches were established as a new mechanism of gene ... The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the ... Cobalamin riboswitch (also B12-element), which binds either adenosylcobalamin (the coenzyme form of vitamin B12) or ...

https://en.wikipedia.org/wiki/Riboswitch

... and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, ... or inhibiting adenylyl cyclase leading to the intracellular increase or decrease of the secondary messenger cyclic AMP. For ... the Gβγ complex associated with a mating factor receptor-coupled G protein in yeast was found to initiate a pheromone response ... The Gβγ complex is an essential element in the GPCR signaling cascade. It has two main states for which it performs different ...

https://en.wikipedia.org/wiki/G_beta-gamma_complex

... cyclic AMP). Some protein hormones also interact with intracellular receptors located in the cytoplasm or nucleus by an ... Most hormones initiate a cellular response by initially binding to either cell membrane associated or intracellular receptors. ... a crucial element in regulating the metabolic rate. Autocrine signaling Adipokine Cytokine Hepatokine Endocrine disease ... An example of the usage of hormone-binding proteins is in the thyroxine-binding protein which carries up to 80% of all ...

https://en.wikipedia.org/wiki/Hormone

Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating Cys172 through ... binding protein, PABP. This disruption of this binding domain results in down regulation of the initiation of cap dependent ... P1 encodes for a proteins (VP1, VP2, VP3, and VP4) that make the capsid proteins. P2 and P3 proteins assist in infectivity of ...

https://en.wikipedia.org/wiki/Picornain_3C

... inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is ... The bacterium contains a surface protein, filamentous haemagglutinin adhesin, which binds to the sulfatides found on cilia of ... This is because B. pertussis inhibits the immune response, so very little mucus is generated in the lungs. A prolonged cough ... The primers used for PCR usually target the transposable elements IS481 and IS1001. Several diagnostic tests are available, ...

https://en.wikipedia.org/wiki/Bordetella_pertussis

... but has no effect on protein kinase C or cyclic AMP-dependent kinase. Mutagenicity does not appear to occur for purified toxins ... When microcystin-LR binds directly to the catalytic center of the PPP enzymes, they block the access of the substrate to the ... These two variable elements are always standard L-amino acids. In microcystin-LR these are leucine and arginine. more than 250 ... There is no change in the expression of selected genes involved in the cellular response to DNA damage after a 4-hour exposure ...

https://en.wikipedia.org/wiki/Microcystin-LR

Then, it converts adenosine triphosphate into cyclic AMP, which activates Protein kinase A. PKA leads to protein tyrosine ... growth hormone response element) IGF-1 and IGFBP-3 expression Via THR/THRE (thyroid hormone response element) Angiotensinogen ... One example of a protein that binds to adaptor proteins and become activated is PLC that is very important in the lymphocyte ... "Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ...

https://en.wikipedia.org/wiki/Biochemical_cascade

... and adenyl cyclase converts AMP into cyclic AMP (cAMP) thereby down-regulating cAMP-responsive proteins involved in cell ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ... Venet F, Lepape A, Debard AL, Bienvenu J, Bohé J, Monneret G (December 2004). "The Th2 response as monitored by CRTH2 or CCR3 ... DP2 activation also stimulates eosinophils and basophils to release the many pro-allergic elements of their granules to the ...

https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor

September 2011). "Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR". ... and thereby the production of the second messenger molecule cyclic AMP), and positively influenced inwardly rectifying ... Similar responses are produced when introduced in alternative methods, only in a more concentrated form than what is naturally ... and certain neuronal elements of the peripheral or central nervous systems (2011). The existence of additional cannabinoid ...

https://en.wikipedia.org/wiki/Cannabinoid_receptor

... most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response. Proteins ... Some of them create second messengers such as cyclic AMP and IP3, the latter controlling the release of intracellular calcium ... Many adaptor proteins and enzymes activated as part of signal transduction possess specialized protein domains that bind to ... has been shown to be a critical element in the plant immune response to signal molecules from bacterial pathogens and plant ...

https://en.wikipedia.org/wiki/Signal_transduction

... though it can also bind phosphothreonine proteins and unphosphorylated proteins. By extension, 14-3-3 proteins are involved in ... Chow CW, Davis RJ (January 2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Molecular and Cellular ... Surfactant is an important element in the maintenance of lung and respiratory functions. A lack of surfactant is closely ... Furthermore, 14-3-3ζ may regulate glucose receptor trafficking in response to insulin levels through its interaction with IRS1 ...

https://en.wikipedia.org/wiki/YWHAZ

... amoeba Dictyostelium discoideum is useful to researchers because they consistently exhibit chemotaxis in response to cyclic AMP ... For a cell to move, it is necessary to bring a fresh supply of "feet" (proteins called integrins, which attach a cell to the ... In addition, cytoskeletal elements are able to interact extensively and intimately with a cell's plasma membrane. Other ... aggregates of a surface molecule are cross-linked with a fluorescent antibody or when small beads become artificially bound to ...

https://en.wikipedia.org/wiki/Cell_migration

... p38 mitogen-activated protein kinases (p38 Mpk), and cAMP response element-binding protein (CREB) which when activated ... production of cyclic AMP [cAMP]); e) G proteins types to which they link and activate, i.e. those containing the Gs alpha ... which binds and responds to PGH2 and TXA2 equally well. All of the prostanoid receptors are G protein-coupled receptors ... They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at ...

https://en.wikipedia.org/wiki/Prostaglandin_receptor

DCC and UNC-5 proteins mediate netrin-1 responses. The UNC-5 protein is mainly involved in signaling repulsion. DCC, which is ... "Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning". Nature. 423 (6943): 990-5 ... Netrins 1, 3, and 4 are secreted proteins, whereas G1 and G2 are membrane bound proteins tethered by Glycophosphatidylinositol ... and integral proteins α6β4 and α3β1. These elements in the extracellular matrix are responsible for epithelial cell adhesion ...

https://en.wikipedia.org/wiki/Netrin

As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP. Cyclic AMP acts ... Secretin is released into circulation and/or intestinal lumen in response to low duodenal pH that ranges between 2 and 4.5 ... Also, the secretion of secretin is increased by the products of protein digestion bathing the mucosa of the upper small ... and the E-box element". Molecular Endocrinology. 18 (7): 1740-55. doi:10.1210/me.2003-0461. PMID 15118068. Lu Y, Owyang C (2009 ...

https://en.wikipedia.org/wiki/Secretin

In protein synthesis, PKA first directly activates CREB, which binds the cAMP response element (CRE), altering the ... AMP-activated protein kinase). Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent ... and a domain to bind the regulatory subunit. The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts ... In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP ( ...

https://en.wikipedia.org/wiki/Protein_kinase_A

... glucagon activates a cyclic AMP pathway; this results in Protein Kinase A, Protein Kinase C, or AMP-activated Protein Kinase ... Each variant differs in their primary tissue of expression, response to protein kinase regulation, and ratio of kinase/ ... The PFK-2 domain appears to be closely related to the superfamily of mononucleotide binding proteins including adenylate ... "An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and ...

https://en.wikipedia.org/wiki/Phosphofructokinase_2

... has recently received special attention as this protein, by associating with the specific nucleotide sequence (GGN repeats) and ... several important cellular and viral proteins regulates crucial biological events such as transcription, repli … ... The single-stranded DNA and RNA binding protein, Puralpha, ... Cyclic AMP Response Element-Binding Protein * DNA-Binding ... The single-stranded DNA and RNA binding protein, Puralpha, has recently received special attention as this protein, by ...

https://pubmed.ncbi.nlm.nih.gov/11169980/?dopt=Abstract

... disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of ... disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of ... disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of ... disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of ...

https://koreauniv.pure.elsevier.com/en/publications/activation-of-cannabinoid-receptor-type-1-cb1r-disrupts-hepatic-i

Cyclic AMP Response Element-Binding Protein. EN. dc.subject. Gene Deletion. EN. ... We examined the deletion of the survival motor neuron [‎SMN]‎ and neuronal apoptosis inhibitory protein [‎NAIP]‎ genes in ...

https://extranet.who.int/iris/restricted/handle/10665/118823?show=full

DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response Element-Binding Protein. ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Proto-Oncogene Protein pp60(c-src). Proto-Oncogene Proteins pp60(c-src). ... Proto-Oncogene Protein c-kit. Proto-Oncogene Proteins c-kit. ... Heat-Shock Proteins 90. HSP90 Heat-Shock Proteins. I-kappa B. I ...

https://decs.bvs.br/I/rep_i2006.htm

Cyclic AMP Response Element-Binding Protein/genetics, Diet, High-Fat, Hyperlipoproteinemias/metabolism, Inflammation/metabolism ... The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, ... The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, ... The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, ...

https://pure.qub.ac.uk/en/publications/crebh-mediates-metabolic-inflammation-to-hepatic-vldl-overproduct

... this model has been modified in response to work showing that postsynaptic differentiation can develop in the absence of ... regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein ... bone morphogenic protein 4 [175,176], and, through the intermediation of their dedicated binding proteins, insulin growth ... Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell ...

https://www.mdpi.com/2073-4409/8/11/1448

Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis ... Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis ... inhibitor rolipram on behavior depend on cyclic AMP-response element binding protein (CREB)-mediated neurogenesis in the ... Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling ...

https://www.semanticscholar.org/paper/Protective-effects-of-a-green-tea-polyphenol%2C-of-in-Ding-Ma/58b83064eb0a0606b456240aba936c8b912ab453?p2df

Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response ... element binding protein- and NF-kappa B-responsive genes. ... transcription of cyclic AMP response element binding protein- ... inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- ... and of RSK2 in mammalian cells and suppressed the phosphorylation of RSK2 substrates cAMP response element binding protein ( ...

https://go.drugbank.com/articles/A18155

Recent advances in protein structure determination and drug development have allowed for generation of highly specific PI3Kγ ... cyclic AMP-response element binding protein)/YAP (yes-associated protein) signaling. Arterioscler. Thromb. Vasc. Biol. 39, e91- ... Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. ... A class of highly selective inhibitors bind to an active state of PI3Kgamma. Nat. Chem. Biol. 15, 348-357 (2019). ...

https://www.nature.com/articles/s41577-022-00701-8?error=cookies_not_supported&code=4987ecc9-1ccb-4768-a869-d89b279df0f4

Chronic ethanol administration decreases phosphorylation of cyclic AMP response element binding protein in granule cells of rat ... Pandey, S.C. The gene transcription factor cyclic AMP-responsive element binding protein: Role in positive and negative ... Pandey, S.C.; Roy, A; Zhang, H.; and Xu, T. Partial deletion of the cAMP response element-binding protein gene promotes alcohol ... acetylation and thus chromatin remodeling may be regulated involves a protein called cyclic-AMP responsive-element binding ( ...

https://pubs.niaaa.nih.gov/publications/arcr343/293-305.htm

... influx via L-type calcium channels activates the SRC/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 ... leading to opposing influences on cAMP response element-binding protein. J Neurosci 25:5066-5078. ... and E2 may affect posttranslational modifications and protein-protein interactions to modulate channel function (Davare and ... 2001) Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Proc Natl Acad Sci U S A 98: ...

https://www.jneurosci.org/content/29/19/6058

Cyclic AMP Response Element-Binding Protein/physiology*. *Mesencephalon/physiology*. *Neurons/cytology*. *Phosphorylation ... The cAMP Response Element-Binding protein (CREB) is a transcription factor important for neuronal survival, differentiation and ...

https://zfin.org/ZDB-PUB-070614-18

Cyclic AMP response element-binding protein A; CrebA. $45.00 Even-skipped. Segmentation protein even-skipped ...

https://dshb.biology.uiowa.edu/custitem16/Rabbit-IgG/custitem34/Drosophila,Sheep

Cyclic-AMP response element-binding protein (CREB) is a protein that regulates gene transcription and is involved in synaptic ... Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult ... significantly decreased the expression levels of both BDNF and cAMP/PKA/phosphorylated cAMP response element-binding protein ( ... Several metal-labeled antibodies bind specific proteins on a tissue slice, and then the tissue is ablated by a laser to produce ...

https://www.researchsquare.com/article/rs-22724/v1

... cyclic AMP response element binding protein,and glycogen synthase kinase 3beta but did not alter extracellular signal-regulated ... kinase, mitogen-activated protein kinase/extracellular signal-regulated kinase, or c-Jun amino-terminal kinase. Thus, direct ...

https://www.healthpartners.com/knowledgeexchange/display/document-rn19523

... inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- ... Cyclic AMP and the heat shock response in Chinese hamster ovary cells. Biochem Biophys Res Commun. 1985 Jan 31; 126(2):911-6. ... Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain. Mol Cell Biol. ... Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in ...

https://connects.catalyst.harvard.edu/Profiles/display/Person/34376

... effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein- ... Ontogeny of rolipram-sensitive, low-K(m), cyclic AMP-specific phosphodiesterase in rat brain. Brain Res Dev Brain Res. 1999; ... Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. ... Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures. Brain Res Dev Brain ...

https://pharmacy.buffalo.edu/content/pharmacy/faculty-staff/faculty-profile.html?ubit=jod

... activities in primary neurons and Caenorhabditis elegans expressing an expanded polyglutamine tract of the huntingtin protein. ... Following dose response curve-dependent selection, we identified the flavonoid luteolin as a primary hit. Further validation in ... Cyclic AMP response element-binding protein. CRC:. Concentration response curve. ER:. Endoplasmic reticulum ... The neuronal-specific protein NeuN, the presynaptic protein synaptophysin, and postsynaptic density protein 95 (PSD95) showed ...

https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00979-5

Cyclic AMP Response Element-Binding Protein 19% 24 引文斯高帕斯（Scopus） ... Vasopressin inhibits endotoxin binding in activated macrophages. Chang, Y. Y., Yang, C. H., Wang, S. C., Kao, M. C., Tsai, P. S ... activator protein-1 and promotes cell mineralisation. Liao, M. H., Tai, Y-T., Cherng, Y-G., Liu, S. H., Chang, Y. A., Lin, P. I ... Genistein induces oestrogen receptor-α gene expression in osteoblasts through the activation of mitogen-activated protein ...

https://tmu.pure.elsevier.com/zh/organisations/department-of-anesthesiology-2/publications/?ordering=publicationYearThenTitle&descending=true&page=6

Ma W, Quirion R: Increased phosphorylation of cyclic AMP response element-binding protein (CREB) in the superficial dorsal horn ... cAMP response element binding protein (pCREB). We chose this marker because of its importance in regulation of many proteins ... 1. Phosphorylated cAMP response element protein (pCREB) immunostaining in dorsal horn of normal and partial sciatic nerve- ... 1. Phosphorylated cAMP response element protein (pCREB) immunostaining in dorsal horn of normal and partial sciatic nerve- ...

https://pubs.asahq.org/anesthesiology/article/98/3/748/40686/Clonidine-induced-Neuronal-Activation-in-the

... extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta ... Protein. You will find the best prices and fastest shipping worldwide on your Supplement needs from our warehouse store. ...

https://www.bestpricenutrition.com/collections/supplements-seen-on-tv/products/solaray-gotu-kola-450mg-100-caps-1

Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic ... the cyclic adenosine monophosphate response element-binding protein, b) serum response element, c) nuclear factor of activated ... the cyclic adenosine monophosphate response element-binding protein, b) serum response element, c) nuclear factor of activated ... Activator protein (AP)‐1, cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), nuclear factor of ...

https://erj.ersjournals.com/content/21/5/759

Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation ... An initial estimator for models with scale parameter when binary response data are observed. Hirai, Y., 1999, In: 岡山大学教育学部研究収録. ... A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei. Hitsuda, T. ...

https://okayama.pure.elsevier.com/en/organisations/faculty-of-education/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=title&descending=true&page=68

... dioxin suppresses contextual fear conditioning-accompanied activation of cyclic AMP response element-binding protein in the ... Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice. ... A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in ... A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose- ...

http://endocrinedisruption.com/interactive-tools/critical-windows-of-development/scientific-references

... with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding ... Plasmids expressing Maltose Binding Protein (MBP)-tagged BRCA2 and KD BRCA2 constructs have been previously described (28, 29 ... Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated ... aiding in the PARPi response. This may explain why RG108 was not able to increase cell response to PARPi. In addition, ROS are ...

https://aacrjournals.org/clincancerres/article/24/13/3163/80952/An-Effective-Epigenetic-PARP-Inhibitor-Combination

Oligodendroglial cyclic AMP response element‐binding protein: A member of the CREB family of transcription factors. Sato‐Bigbee ... is an ATPase containing multiple members of a nucleotide-binding protein family. DeMartino, G. N., Moomaw, C. R., Zagnitko, O. ... PA28 activator protein forms regulatory caps on proteasome stacked rings. Gray, C. W., Slaughter, C. A. & DeMartino, G. N., Feb ... Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Mao, C. A. N., Gan, L. & ...

https://augusta.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2011&publicationYear=2013&publicationYear=2014&publicationYear=2015&publicationYear=2016&publicationYear=2017&publicationYear=2018&publicationYear=2019&publicationYear=2020&format=&nofollow=true&ordering=publicationYearThenTitle&descending=true&page=895

Human Cyclic AMP response element binding protein,CREB ELISA Kit. 634€. Human Cyclic AMP-dependent transcription factor ATF-2, ... Human Cyclic AMP-dependent transcription factor ATF-6,ATF-6 ELISA Kit. 634€ ...

http://usachinabio.com/catalogue/178339-bioassay?page=23

Cyclic AMP Response Element-Binding Protein Entry term(s). CREB Protein Cyclic AMP Responsive DNA Binding Protein Cyclic AMP- ... DNA-Binding Protein, Cyclic AMP-Responsive cAMP Response Element Binding Protein cAMP Response Element-Binding Protein ... DNA-Binding Protein, Cyclic AMP-Responsive. cAMP Response Element Binding Protein. cAMP Response Element-Binding Protein. ... CREB Protein. Cyclic AMP Responsive DNA Binding Protein. Cyclic AMP-Responsive DNA-Binding Protein. DNA Binding Protein, Cyclic ...

https://decs.bvsalud.org/en/ths/resource/?id=30748

Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. (semanticscholar.org)
NSAIDs inhibited the activity of purified RSK2 kinase in vitro and of RSK2 in mammalian cells and suppressed the phosphorylation of RSK2 substrates cAMP response element binding protein (CREB) and I-kappa B alpha in vivo. (drugbank.com)
The cAMP Response Element-Binding protein (CREB) is a transcription factor important for neuronal survival, differentiation and plasticity. (zfin.org)
Activator protein (AP)‐1, cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), nuclear factor of activated T‐cells (NFAT), nuclear factor (NF)‐κB, the serum response element (SRE) complex and signal transducer and activator of transcription (STAT) are all known to be involved in proliferation and/or inflammation and have been implicated in the inflammatory state causing asthma and related airway diseases 8 . (ersjournals.com)
cAMP-response element binding protein (CREB) is a nuclear transcription factor activated by multiple extracellular signals including growth factors and hormones. (elsevier.com)
These extracellular cues activate CREB through phosphorylation at Ser133 by various protein serine/threonine kinases. (elsevier.com)
Once phosphorylated, it promotes its association with transcription coactivators CREB-binding protein (CBP) and its paralog p300 to activate CREB-dependent gene transcription. (elsevier.com)
We also investigated the effects of acupuncture stimulation at GV20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) in the hippocampus. (biomedcentral.com)
Acupuncture stimulation at GV20 significantly alleviated memory-associated decreases in the levels of choline acetyltransferase (ChAT), BDNF and CREB proteins in the hippocampus. (biomedcentral.com)
Phosphorylation of CREB to pCREB (phosphorylated cyclic AMP response element binding protein) is increased after predator stress in fear circuitry, including in the right lateral column of the PAG (periaqueductal gray). (mun.ca)
Increasing CREB expression in right PAG was anxiogenic in the elevated plus maze, had no effect on risk assessment, and increased acoustic startle response while delaying startle habituation. (mun.ca)
The AP-1 activity binds efficiently to both AP-1 and activating transcription factor (ATF)/cAMP response element binding protein (CREB)-binding sites present in E1A-inducible promoters and presumably plays a role in the transcriptional activation of adenovirus genes by E1A proteins and cAMP. (princeton.edu)
Signalling pathway inhibitors were used to examine the roles of Rho, PKA, the cAMP response element binding protein (CREB) and NF-κB on the PGE 2 stimulated up-regulation of Nurr1. (arizona.edu)
Using primary cultures of ovarian granulosa cells from gonadotropin-primed immature rats, we have recently discovered that pituitary FSH and ovarian cytokine transforming growth factor beta 1 (TGFβ1) induce calcineurin-mediated dephosphorylation-activation of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC2) to modulate the expression of Star, Cyp11a1, and Hsd3b leading to increased production of progesterone. (nycu.edu.tw)
It is known that the ovary-specific Cyp19a1 PII-promoter contains crucial response elements for CREB and nuclear receptor NR5A subfamily liver receptor homolog 1 (LRH1/NR5A2) and steroidogenic factor 1 (SF1/NR5A1), and that the Nr5a2 promoter also has a potential CREB-binding site. (nycu.edu.tw)
In addition, FSH and TGFβ1 increased CRTC2 binding to the Cyp19a1 PII-promoter and Nr5a2 promoter at 24 h, with CREB bound constitutively. (nycu.edu.tw)
As the figure shows, MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). (cusabio.com)

Evidence is provided to support the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol-3 kinase/ protein kinase B (PI3K/AKT) pathways in EGCG-mediated protection against corticosterone-induced neuron injuries. (semanticscholar.org)
Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. (drugbank.com)
Our findings indicate that ribosomal S6 kinase 2 (RSK2), a 90-kDa ribosomal S6 kinase with a critical role as an effector of the RAS-mitogen-activated protein kinase pathway and a regulator of immediate early gene transcription is a target for inhibition by the NSAIDs. (drugbank.com)
Intranasal delivery of insulin was associated with greater preservation of the phosphatidylinositol 3-kinase signaling pathway involving Akt, cyclic AMP response element binding protein,and glycogen synthase kinase 3beta but did not alter extracellular signal-regulated kinase, mitogen-activated protein kinase/extracellular signal-regulated kinase, or c-Jun amino-terminal kinase. (healthpartners.com)
In summary, extracellular signal-regulated kinase activation is required for many transcription factor responses to lysophosphatidic acid and epidermal growth factor, however it is not synergistic. (ersjournals.com)
One key proliferative signalling mediator is the extracellular signal-regulated kinase (ERK), a member of the mitogen-activation protein kinase (MAPK) family, and both LPA and EGF signal through ERK in many cell types 6 , 7 . (ersjournals.com)
Serum/glucticocorticoid kinase (SGK) phosphorylates SRF at serine residue 103 in response to multiple upstream stimuli (Tyan et al, 2008). (reactome.org)
Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. (uni-freiburg.de)
The objective of this study was to determine whether the increased AKT or MAPK kinase-1/2 (MEK1/2) activity observed in endometriotic stromal cells (OSIS) from ovarian endometriomas influences levels of PR protein. (webpediatrica.com)
Provided the limited precedent, collection of a suitable collection to screen a fresh class of focus on, such as for example an inositol phosphate kinase, is certainly a critical element of the complete HTS technique. (immune-source.com)
For the existing research we posited the fact that even more hydrophobic nucleotide-binding site of the inositol phosphate kinase would provide a possibly even more tractable focus on [23]. (immune-source.com)

HASM cells grown in vitro proliferate in response to a variety of stimuli, including G protein-coupled receptor (GPCR) agonists as well as peptide growth factors acting via receptor tyrosine kinases (RTKs) 1 , 2 . (ersjournals.com)
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. (bvsalud.org)
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. (uni-freiburg.de)
Activation of extracellular signal-regulated kinases, NF-kappa B, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia. (uchicago.edu)
Kinases can cause posttranslational modifications of the progesterone receptor (PR) to influence cellular localization and protein stability. (webpediatrica.com)
Our selection of a collection was influenced with the recognition the fact that substrate binding storage compartments of inositol phosphate kinases are extremely electropositive buy Protopanaxatriol [7,8,21,22]. (immune-source.com)
Using the nucleotide-binding sites of proteins TNR kinases specifically at heart as drug-targets, several chemical libraries have already been curated that consist of substances either knownor forecasted and purified to homogeneity [8]. (immune-source.com)

The locus of Rubinstein-Taybi syndrome is located on band 16p13.3, which includes a gene encoding a binding protein for cyclic adenosine monophosphate-response element binding protein (CBP) (CREBBP or CBP gene) that is responsible for the phenotype of Rubinstein-Taybi syndrome. (medscape.com)

Xu Y, Cao Z, Khan I, Luo Y. Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. (bestpricenutrition.com)
A selective increase in phosphorylation of cyclic AMP response element-binding protein in hippocampal CA1 region of male, but not female, rats following contextual fear and passive avoidance conditioning. (bvsalud.org)
Recent studies have demonstrated that light induces the expression of Fos and phosphorylation of the cyclic-AMP response element-binding protein in the rodent suprachiasmatic nuclei, the location of a master circadian pacemaker in mammals, suggesting that these transcription factors may mediate the effects of light on the circadian clock. (elsevier.com)
The purpose of this study was to determine the effects of aging upon light-induced phase-shifting of circadian locomotor activity rhythms, Fos protein expression and cyclic-AMP response element-binding protein phosphorylation in the suprachiasmatic nuclei. (elsevier.com)
Aging was also associated with a deficit in cyclic-AMP response element-binding protein phosphorylation by light. (elsevier.com)
Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR) , tyrosinase-related protein 1 (TYRP1) , and dopachrome tautomerase (DCT) , which produce melanin. (cusabio.com)

Gene categorization showed that most of the differentially expressed genes are involved in oxidative stress response, and pathway analysis further revealed that Nrf2-mediated oxidative stress pathway is the top of the ITC-modulated signaling pathway. (researchgate.net)
Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3α (HIF3α), peroxisome proliferator-activated receptor alpha (PPARα), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS. (biomedcentral.com)
E1A proteins and cAMP work in synergy to activate several of these genes. (princeton.edu)
Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)

The single-stranded DNA and RNA binding protein, Puralpha, has recently received special attention as this protein, by associating with the specific nucleotide sequence (GGN repeats) and/or several important cellular and viral proteins regulates crucial biological events such as transcription, replication, and cell proliferation. (nih.gov)

Specifically, overexpression of CREBH significantly induced mRNA and protein expression of apoB in McA-7777 cells. (qub.ac.uk)
Activation of CREBH in inflammation enhances mRNA and protein expression of apoB. (qub.ac.uk)
We evaluated receptor mRNA and protein expression levels and effects of octreotide, pasireotide, and cabergoline on ACTH secretion by cultured human corticotroph adenoma cells. (webpediatrica.com)
Real-time PCR and Western blotting were used to assess mRNA and protein expression of cartonectin. (webpediatrica.com)

The number of cells in superficial and deep dorsal horn laminae at the L4-L5 level immunostained for phosphorylated cAMP response element binding protein (pCREB) were quantified. (asahq.org)

2 Cerebral ischemia can trigger inflammatory responses, including the activation of microglia, macrophages, neutrophils, and dendritic cells. (researchsquare.com)

Additionally, luteolin treatment improved mitochondrial and locomotory activities in primary neurons and Caenorhabditis elegans expressing an expanded polyglutamine tract of the huntingtin protein. (biomedcentral.com)

This has involved the study of noradrenergic mechanisms in the actions of antidepressant drugs and of cyclic nucleotide phosphodiesterases as potential targets for novel antidepressant, anxiolytic, and memory-enhancing drugs. (buffalo.edu)
He is a member of a number of scientific and professional societies, including the American Society for Pharmacology and Experimental Therapeutics and the Society for Neuroscience, is a Fellow of the American College of Neuropsychopharmacology, and chaired the Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases. (buffalo.edu)
Activation of the inhibitory guanine nucleotide-binding protein and of ERK signalling pathways were required for most transcription factor responses to LPA. (ersjournals.com)

The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, enhances very-low-density lipoprotein (VLDL) assembly and secretion by upregulating apolipoprotein B (apoB) expression and contributes to metabolic inflammation-associated hyperlipoproteinemia induced by TNFα, lipopolysaccharides (LPS), and high-fat diet (HFD) in mice. (qub.ac.uk)
This novel finding establishes CREBH as the first transcription factor that regulates apoB expression on the transcriptional level and the subsequent VLDL biosynthesis in response to metabolic inflammation. (qub.ac.uk)

The regulatory protein of the human neurotropic virus, JCV, T-antigen, which interacts with Puralpha, decreased transcriptional activity of the Puralpha promoter. (nih.gov)
CBP and EP300 are ubiquitously expressed homologous proteins that act as transcriptional co-activators. (medscape.com)

BACKGROUND AND PURPOSE Prostaglandin E 2 (PGE 2 ) stimulation of the G protein-coupled prostanoid EP 1 receptor was found to up-regulate the expression of Nur-related factor 1 (Nurr1) (NR4A2), a transcription factor in the NR4A subfamily of nuclear receptors. (arizona.edu)
Ovarian granulosa cells treated with FSH displayed increased aromatase protein at 24 h post-treatment, which subsided by 48 h, while TGFβ1 acting through its type 1 receptor augmented the action of FSH with a greater and longer effects. (nycu.edu.tw)

A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. (lykon.de)

Aging is associated with a variety of alterations in circadian rhythms, including changes in the response to environmental stimuli. (elsevier.com)

This protein functions to integrate both calcium and cAMP signals. (bvsalud.org)
We now demonstrate that the transcription factor AP-1 is modestly induced by cAMP in S49 cells and induced to significantly higher levels by cAMP in the presence of E1A proteins. (princeton.edu)
Cytoplasmic levels of c-fos and junB mRNAs are rapidly increased by cAMP, and the induction is substantially stronger in the presence of E1A protein. (princeton.edu)

In the sevoflurane anesthetized neonatal rat model, treatment with HPD reduced neuronal degeneration, hippocampal inflammation, and improvised memory, learning, and cognitive responses by modulating the PI3/Akt/PTEN and NF-κB signaling pathways. (semanticscholar.org)

Basidiocarps of A. hygrometricus are rich in proteins, carbohydrates, minerals, crude fibre and essential amino acids with lower concentration of fat. (fulltxt.org)
4 Edible mushrooms are low calorie-low fat food supplement with generous amount of proteins, carbohydrates, vitamins, minerals amino acids 5 and dietary fibre. (fulltxt.org)

The EP300 gene on band 22q13 encodes a protein, p300, that is highly similar to CREBBP. (medscape.com)

Finally, real-time polymerase chain reaction (PCR) and Western blotting confirmed the gene expression and protein products of the major targets by ITCs. (researchgate.net)

While agrin was initially postulated to be the inductive molecule that initiates synaptogenesis, this model has been modified in response to work showing that postsynaptic differentiation can develop in the absence of innervation, and that synapses can form in transgenic mice in which the agrin gene is ablated. (mdpi.com)

Basidiocarp of this macrofungi contains considerable amount of carbohydrate, protein, fibre, minerals, vitamins, essential amino acids and very minute concentration of fat. (fulltxt.org)

HASM cells show increased mitogenesis in response to LPA, a GPCR mitogen, and to epidermal growth factor (EGF), an RTK growth factor. (ersjournals.com)
Interestingly, HASM cells treated with LPA together with EGF show a strikingly synergistic stimulation of mitogenesis, much greater than the sum of the responses to the two agents alone 4 , 5 . (ersjournals.com)
In histopathological examinations (toluidine blue (T.B.), major basic protein (MBP), CD4, IL-4, IL-5, eotaxin, TARC and IgE), the wasabi rhizome-containing HR-AD diet (5% and 10%) significantly reduced the number of positive stained cells. (researchgate.net)
Here, we found that coffee ingredients, namely caffeine and theobromine, decreased the protein level of CLDN2 in human lung adenocarcinoma-derived A549 cells. (bvsalud.org)
In a protein-stability assay using cycloheximide, CLDN2 protein levels decreased faster in caffeine-treated cells than in vehicle-treated cells. (bvsalud.org)
Inhibiting AKT with MK-2206 or MEK1/2 with U0126 for 24 hours in the absence of R5020 increased total and nuclear PRA and PRB protein levels in OSIS but not in eutopic endometrial stromal cells from disease-free patients from disease-free patients. (webpediatrica.com)

Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein. (uchicago.edu)

Co-expression of JCV T-antigen and Puralpha had no significant effect on the suppression of Puralpha gene transcription by either protein. (nih.gov)
There were no statistically significant differences in sst 5 and D 2 R mRNA expression or in sst 2 , sst 5 , and D 2 R protein expression between both groups of corticotroph adenomas. (webpediatrica.com)
Whether sustained normocortisolism induced by medical therapy induces re-expression of functional sst 2 protein in corticotroph adenomas and whether this increases the ACTH-lowering potency of octreotide remains to be established. (webpediatrica.com)

These data indicate that there are dramatic changes in light-activated molecular responses in the suprachiasmatic nuclei of old hamsters, and suggest that these molecular changes may underlie age-related changes in the effects of light on the circadian clock system. (elsevier.com)

Rapid activation of Rho was observed in response to LPA but not to EGF. (ersjournals.com)
Activation of activator protein‐1 is synergistic, and Rho activation by lysophosphatidic acid is required for synergism in both activator protein‐1 activation and mitogenesis. (ersjournals.com)

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response. (bu.edu)

Young (three to four months) and old (18-22 months) male golden hamsters free-running in constant darkness were exposed to 5-min monochromatic light pulses of different irradiance levels, at circadian time 19, after which either steady-state phase shifts of locomotor activity rhythms were measured, or else immunocytochemistry for Fos or for phospho-cyclic-AMP response element-binding protein was performed. (elsevier.com)
Herein, we demonstrate that FSHCTGFβ1 increased LRH1 and SF1 protein levels, and their binding to the Cyp19a1 PII-promoter evidenced, determined by chromatin immunoprecipitation analysis. (nycu.edu.tw)

To ameliorate this issue, interest is continuing to grow in rendering screening process more efficient, with the curation and program of smaller, concentrated libraries that focus on proteins households with functionally or chemically related binding sites [17]. (immune-source.com)
Such ligand-binding sites will be expected and then be successfully occupied by polar substances that usually do not easily combination cell buy Protopanaxatriol membranes, hence possibly deeming inositol phosphate binding storage compartments to become undruggable [23]. (immune-source.com)

Application of DNA-based tests for diagnosis of spinal muscular atrophy in Saudi Arabia (extranet.who.int)

CREBH mediates metabolic inflammation to hepatic VLDL overproduction and hyperlipoproteinemia<... (pure.qub.ac.uk)

Cells | Free Full-Text | Nerve, Muscle, and Synaptogenesis (mdpi.com)

PDF] Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis... (semanticscholar.org)

The role of PI3Kγ in the immune system: new insights and translational implications | Nature Reviews Immunology (nature.com)

Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response... (go.drugbank.com)

Publications | National Institute on Alcohol Abuse and Alcoholism | Update on the Genetics of Alcoholism (pubs.niaaa.nih.gov)

ZFIN Publication: Dworkin et al., 2007 (zfin.org)

Antineuroinflammatory effects of dl-3-n-butylphthalide conferred by stimulation of Foxp3 and Ki-67 in an ischemic stroke model ... (researchsquare.com)

Mary Stevenson | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)

Tony Wyss-Coray, PhD's Profile | Stanford Profiles (profiles.stanford.edu)

Anatomy3

Organisms1

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes18

Information Science3

A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. (1/16)

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (2/16)

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. (3/16)

Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. (4/16)

Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2. (5/16)

Identification and analysis of two splice variants of human G2A generated by alternative splicing. (6/16)

The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. (7/16)

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (8/16)

Cyclic AMP Response Element-Binding Protein

Phosphorylation

Promoter Regions, Genetic

Transcription, Genetic

Cyclic AMP

Cyclic AMP Response Element Modulator

CREB-Binding Protein

Response Elements

Sterol Regulatory Element Binding Protein 1

Transcription Factors

Activating Transcription Factor 2

DNA-Binding Proteins

Base Sequence

Activating Transcription Factor 1

Molecular Sequence Data

Activating Transcription Factors

Gene Expression Regulation

Sterol Regulatory Element Binding Protein 2

Cyclic AMP-Dependent Protein Kinases

Nuclear Proteins

RNA, Messenger

Transcriptional Activation

Cell Line

Signal Transduction

Binding Sites

Leucine Zippers

Regulatory Sequences, Nucleic Acid

Cells, Cultured

Transfection

DNA

Protein Binding

Sterol Regulatory Element Binding Proteins

Proto-Oncogene Proteins c-fos

CCAAT-Enhancer-Binding Proteins

Gene Products, tax

Colforsin

Gene Expression Regulation, Enzymologic

Genes, Reporter

G-Box Binding Factors

Enhancer Elements, Genetic

Amino Acid Sequence

Transcription Factor AP-1

Rats, Sprague-Dawley

Proto-Oncogene Proteins c-jun

Enzyme Activation

Chloramphenicol O-Acetyltransferase

Mitogen-Activated Protein Kinases

Tumor Cells, Cultured

Trans-Activators

DNA Primers

NF-kappa B

Brain-Derived Neurotrophic Factor

A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. (1/16)

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. (2/16)

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. (3/16)

Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. (4/16)

Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2. (5/16)

Identification and analysis of two splice variants of human G2A generated by alternative splicing. (6/16)

The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. (7/16)

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (8/16)

TWSG1 / Tsg antibody | acris-antibodies.com

The C<sub>2</sub>H<sub>2</sub> transcription factor REGULATOR OF SYMBIOSOME DIFFERENTIATION represses transcription of the...

Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...

Pjdr2 0824 - Glycoside hydrolase family 16 precursor - Paenibacillus sp. (strain JDR-2) - Pjdr2 0824 gene & protein

ATF2 (pT73/T55) Antibody | Abbexa Ltd

Altmetric - Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

Transcription of two adjacent carbohydrate utilization gene clusters in Bifidobacterium breve UCC2003 is controlled by LacI-...

PPT - Best Melbourne Massage Therapy Center PowerPoint Presentation - ID:7291953

Ophthalmic Devices & Solutions | kanchan eye instruments(Odhav Ahmedabad),| obisindia

ICG001/ICG-001/ICG 001/847591-62-2/acesobio supply

Drosophila melanogaster Larval cuticle protein 3 (Lcp3) GENTAUR-58b386129b20e | Gentaursearch

Mouse NFIL3/E4BP4 Alexa Fluor® 750-conjugated Antibody (IC8888S) | Bio-Techne

Dr. Howard Budner & Associates Optometrists - Optometrist in Fairfax, VA US

ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE: II. COMPARISON WITH OTHER TESTS.<...

Interactive Fly, Drosophila

Obama: New sanctions against Russia are teed up

Cuba! An eight-day home stay tour of Western Cuba - Day 2 | WeStCoaSTGiRL

Custom News App - New

Mitochondrial Signals for the Nucleus | Science Signaling

Journal of Cell Science