Cyclic AMP Response Element-Binding Protein
Phosphorylation
Promoter Regions, Genetic
Transcription, Genetic
Cyclic AMP
Cyclic AMP Response Element Modulator
CREB-Binding Protein
Response Elements
Sterol Regulatory Element Binding Protein 1
Transcription Factors
Activating Transcription Factor 2
DNA-Binding Proteins
Base Sequence
Activating Transcription Factor 1
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Activating Transcription Factors
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
Gene Expression Regulation
Sterol Regulatory Element Binding Protein 2
Cyclic AMP-Dependent Protein Kinases
Nuclear Proteins
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Transcriptional Activation
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Binding Sites
Leucine Zippers
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
Regulatory Sequences, Nucleic Acid
Cells, Cultured
Transfection
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Protein Binding
Sterol Regulatory Element Binding Proteins
Proto-Oncogene Proteins c-fos
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
CCAAT-Enhancer-Binding Proteins
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Gene Products, tax
Colforsin
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Gene Expression Regulation, Enzymologic
Genes, Reporter
G-Box Binding Factors
Enhancer Elements, Genetic
Amino Acid Sequence
Transcription Factor AP-1
Rats, Sprague-Dawley
Proto-Oncogene Proteins c-jun
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
Enzyme Activation
Chloramphenicol O-Acetyltransferase
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Tumor Cells, Cultured
Trans-Activators
DNA Primers
NF-kappa B
Brain-Derived Neurotrophic Factor
ATF-2-binding regulatory element is responsible for the Ly49A expression in murine T lymphoid line, EL-4. (1/3445)
To understand the mechanism of Ly49A-expression and its significance in T-cell differentiation, we analyzed the 5'-flanking region of the Ly49A gene in a search for the Ly49A-regulatory element. Since very few known regulatory elements have been found in this region, presumably a novel regulatory sequence(s) could exist. Accordingly, we defined the 13-bp regulatory element, 5'-ATGACGAGGAGGA-3', restricted to Ly49A-expression in EL-4 cells in comparison with two other representative cell lines tested. This element, designated as EL13, proved to be previously undiscovered by homology search and is highly homologous with several virus DNAs. Using EL13 as a probe we have cloned a cDNA encoding a binding protein to EL13. Its deduced nucleotide sequence revealed that EL13-binding protein is almost identical with rat ATF-2. Although ATF-2 is known to bind to cyclic AMP responsive element (CRE), EL13 shares five out of eight nucleotides with this consensus sequence. Our results suggested that ATF-2 may play an important role via binding to EL13 for the expression of Ly49A. These data will provide useful information for understanding T-cell and NK-cell differentiation in murine immune system. (+info)A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter. (2/3445)
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol synthesis, is a target for negative feedback regulation by cholesterol. When cellular sterol levels are low, the sterol regulatory element-binding proteins (SREBPs) are released from the endoplasmic reticulum membrane, allowing them to translocate to the nucleus and activate SREBP target genes. However, in all SREBP-regulated promoters studied to date, additional co-regulatory transcription factors are required for sterol-regulated activation of transcription. We have previously shown that, in addition to SREBPs, NF-Y/CBF is required for sterol-regulated transcription of HMG-CoA synthase. This heterotrimeric transcription factor has recently been shown to function as a co-regulator in several other SREBP-regulated promoters, as well. In addition to cis-acting sites for both SREBP and NF-Y/CBF, the sterol regulatory region of the synthase promoter also contains a consensus cAMP response element (CRE), an element that binds members of the CREB/ATF family of transcription factors. Here, we show that this consensus CRE is essential for sterol-regulated transcription of the synthase promoter. Using in vitro binding assays, we also demonstrate that CREB binds to this CRE, and mutations within the CRE that result in a loss of CREB binding also result in a loss of sterol-regulated transcription. We further show that efficient activation of the synthase promoter in Drosophila SL2 cells requires the simultaneous expression of all three factors: SREBPs, NF-Y/CBF, and CREB. To date this is the first promoter shown to require CREB for efficient sterol-regulated transcription, and to require two different co-regulatory factors in addition to SREBPs for maximal activation. (+info)CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. (3/3445)
The cyclic AMP response element (CRE) of the rat phosphoenolpyruvate carboxykinase (PEPCK) gene promoter is required for a complete glucocorticoid response. Proteins known to bind the PEPCK CRE include the CRE-binding protein (CREB) and members of the CCAAT/enhancer-binding protein (C/EBP) family. We took two different approaches to determine which of these proteins provides the accessory factor activity for the glucocorticoid response from the PEPCK CRE. The first strategy involved replacing the CRE of the PEPCK promoter/chloramphenicol acetyltransferase reporter plasmid (pPL32) with a consensus C/EBP-binding sequence. This construct, termed pDeltaCREC/EBP, binds C/EBPalpha and beta but not CREB, yet it confers a nearly complete glucocorticoid response when transiently transfected into H4IIE rat hepatoma cells. These results suggest that one of the C/EBP family members may be the accessory factor. The second strategy involved co-transfecting H4IIE cells with a pPL32 mutant, in which the CRE was replaced with a GAL4-binding sequence (pDeltaCREGAL4), and various GAL4 DNA-binding domain (DBD) fusion protein expression vectors. Although chimeric proteins consisting of the GAL4 DBD fused to either CREB or C/EBPalpha are able to confer an increase in basal transcription, they do not facilitate the glucocorticoid response. In contrast, a fusion protein consisting of the GAL4 DBD and amino acids 1-118 of C/EBPbeta provides a significant glucocorticoid response. Additional GAL4 fusion studies were done to map the minimal domain of C/EBPbeta needed for accessory factor activity to the glucocorticoid response. Chimeric proteins containing amino acid regions 1-84, 52-118, or 85-118 of C/EBPbeta fused to the GAL4 DBD do not mediate a glucocorticoid response. We conclude that the amino terminus of C/EBPbeta contains a multicomponent domain necessary to confer accessory factor activity to the glucocorticoid response from the CRE of the PEPCK gene promoter. (+info)CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period. (4/3445)
Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synaptic rearrangement during a postnatal developmental window, the critical period. Here, using transgenic mice carrying a CRE-lacZ reporter, we demonstrate that a calcium- and cAMP-regulated signaling pathway is activated following monocular deprivation. We find that monocular deprivation leads to an induction of CRE-mediated lacZ expression in the visual cortex preceding the onset of physiologic plasticity, and this induction is dramatically downregulated following the end of the critical period. These results suggest that CRE-dependent coordinate regulation of a network of genes may control physiologic plasticity during postnatal neocortical development. (+info)Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. (5/3445)
Platelet-derived growth factor (PDGF) BB, a mitogen that stimulates bone resorption, increases the expression of interleukin-6 (IL-6), a cytokine that induces osteoclast recruitment. The mechanisms involved in IL-6 induction by PDGF BB are poorly understood. We examined the effect of PDGF BB on IL-6 expression in cultures of osteoblasts from fetal rat calvariae (Ob cells). PDGF BB increased IL-6 mRNA and heterogeneous nuclear RNA levels, the rate of transcription, and the activity of base pairs (bp) -2906 to +20 IL-6 promoter fragments transiently transfected into Ob cells. Deletion analysis revealed two responsive regions, one containing an activator protein-1 (AP-1) site located between bp -276 and -257, and a second, less well defined, downstream of -257. Targeted mutations of a cyclic AMP-responsive element (CRE), and nuclear factor-IL-6 and nuclear factor-kappaB binding sites in a bp -257 to +20 IL-6 construct that was transfected into Ob cells, revealed that the CRE also contributed to IL-6 promoter induction by PDGF BB. Electrophoretic mobility shift assay revealed AP-1 and CRE nuclear protein complexes that were enhanced by PDGF BB. Supershift assays revealed binding of Jun and Fos to AP-1 and CRE sequences and binding of activating transcription factor-2 to CRE. In conclusion, PDGF BB induces IL-6 transcription in osteoblasts by regulating nuclear proteins of the AP-1 complex and activating transcription factor-2. (+info)pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. (6/3445)
The cyclin D1 gene is overexpressed in breast tumors and encodes a regulatory subunit of cyclin-dependent kinases that phosphorylate the retinoblastoma protein. pp60(c-src) activity is frequently increased in breast tumors; however, the mechanisms governing pp60(c-src) regulation of the cell cycle in breast epithelium are poorly understood. In these studies, pp60(v-src) induced cyclin D1 protein levels and promoter activity (48-fold) in MCF7 cells. Cyclin D1-associated kinase activity and protein levels were increased in mammary tumors from murine mammary tumor virus-pp60(c-src527F) transgenic mice. Optimal induction of cyclin D1 by pp60(v-src) involved the extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase members of the mitogen-activated protein kinase family. Cyclin D1 promoter activation by pp60(v-src) involved a cAMP response element-binding protein (CREB)/activating transcription factor 2 (ATF-2) binding site. Dominant negative mutants of CREB and ATF-2 but not c-Jun inhibited pp60(v-src) induction of cyclin D1. pp60(v-src) induction of CREB was blocked by the p38 inhibitor SB203580 or by mutation of CREB at Ser133. pp60(v-src) induction of ATF-2 was abolished by the c-Jun N-terminal kinase inhibitor JNK-interacting protein-1 or by mutation of ATF-2 at Thr69 and Thr71. CREB and ATF-2, which bind to a common pp60(v-src) response element, are transcriptionally activated by distinct mitogen-activated protein kinases. Induction of cyclin D1 activity by pp60(v-src) may contribute to breast tumorigenesis through phosphorylation and inactivation of the retinoblastoma protein. (+info)CREB regulates MHC class II expression in a CIITA-dependent manner. (7/3445)
The X2 box of MHC class II promoters is homologous to TRE/CRE elements and is required for expression of MHC class II genes. The X2 box-specific DNA binding activity, X2BP, was purified to homogeneity, sequenced, and identified as CREB. Transient transactivation experiments showed that CREB can cooperate with CIITA to enhance activation of transcription from MHC class II promoters in a dose-dependent manner. Binding of CREB to the class II promoter in vivo was demonstrated by a chromatin immunoprecipitation assay. Additionally, ICER, a dominant inhibitor of CREB function, was found to repress class II expression. These results demonstrate that CREB binds to the X2 box in vivo and cooperates with CIITA to direct MHC class II expression. (+info)Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein. (8/3445)
The long terminal repeat (LTR) of human T-cell leukemia virus type 1 (HTLV-1) has two distinct DNA elements, one copy of TRE2S and three copies of a 21-bp sequence that respond to the viral trans-activator protein, Tax. Either multiple copies of the 21-bp sequence or a combination of one copy each of TRE2S and 21-bp sequence is required for efficient trans activation by Tax. In the trans activation of multiple copies of 21-bp sequence, CREB/ATF protein plays an essential role in forming a complex with Tax. To understand the role of TRE2S in trans activation of one copy of 21-bp sequence, we examined protein binding to the DNA elements by DNA affinity precipitation assay including Gli2 protein binding to TRE2S and CREB protein binding to 21-bp sequence. Binding of CREB to a DNA probe containing both elements, TRE2S-21bp probe, was dependent on Gli2 protein under restricted conditions and was enhanced in a dose-dependent fashion by the binding of Gli2 protein to the same probe. Mutation in either element abolished the efficient binding of CREB. A glutathione S-transferase fusion protein of a fragment of Gli2 was able to bind to CREB. Therefore, Gli2-CREB interaction on the DNA probe is proposed to stabilize CREB binding to DNA. Tax can bind to CREB protein on the DNA; therefore, stabilization of DNA binding of CREB results in more recruitment of Tax onto DNA. Conversely, Tax increased the DNA binding of CREB, although it had almost no effect on the binding of Gli2. These results suggest that Gli2 binds to the DNA element and interacts with CREB, resulting in more recruitment of Tax, which in turn stabilizes DNA binding of CREB. Similar cooperation of the protein binding to TRE2S-21bp probe was also observed in nuclear extract of an HTLV-1-infected T-cell line. Consistent with the Gli2-CREB interaction on the DNA elements, Tax-mediated trans activation was dependent on the size of the spacer between TRE2S and 21-bp sequence. The effective sizes of the spacer suggest that TRE2S in the LTR would cooperate with the second and third copies of the 21-bp sequence and contribute to trans activation of the viral gene transcription. (+info)
The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization, Co...
The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies - Fingerprint
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Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex | Molecular Brain |...
CAMP-responsive element-binding protein 3-like protein 1 | definition of cAMP-responsive element-binding protein 3-like protein...
CAMP-responsive element-binding protein 3-like protein 4 | definition of cAMP-responsive element-binding protein 3-like protein...
Thiopental Inhibits the Activation of Nuclear Factor κB | Anesthesiology | American Society of Anesthesiologists
Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB...
Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...
Plus it
Cleavage of cyclic AMP-responsive element-binding protein H aggravates myocardial hypoxia reperfusion injury in a hepatocyte...
北京大å¦åŒ»å¦éƒ¨æœºæž„知识库([email protected]): cAMP Responsive Element Binding Protein-1 Is a Transcription Factor of Lysosomal-Associated Protein...
Creb1 - Cyclic AMP-responsive element-binding protein 1 - Rattus norvegicus (Rat) - Creb1 gene & protein
Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription<...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...
Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene...
Volume 11.20 | May 31 - Cell Therapy News
A rice dehydration-inducible SNF1-related protein kinase 2 phosphorylates an abscisic acid responsive element-binding factor...
Relaxin activates peroxisome proliferator-activated receptor γ(PPAR γ)through a pathway involving PPAR γ coactivator 1α (PGC1α)...
Active Motif » TransAM CREB (cyclic AMP response element binding, CREB and Phosphorylated CREB (Ser133) DNA binding ELISAs)
Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum
crebl2 Protein, cAMP responsive element binding protein-like 2 - Creative BioMart
Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning. - Semantic Scholar
Transcription Factor Assisted Loading and Enhancer Dynamics Dictate the Hepatic Fasting Response - Philippine Genome Center
anti-CREB3L1 antibody [C3], C-term | GeneTex
Early Odor Preference Learning in the Rat: Bidirectional Effects of cAMP Response Element-Binding Protein (CREB) and Mutant...
Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide...
Directly Modulating Glucose Homeostasis | Science Signaling
4-PPBP - Wikipedia
JCI -
Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
cAMP Response Element-Binding Protein Is Required for Stress But Not Cocaine-Induced Reinstatement at The University of...
Anti CREB1 Antibody | Bio-Rad Antibodies (formerly AbD Serotec)
Heme Deficiency Interferes with the Ras-Mitogen-activated Protein Kinase Signaling Pathway and Expression of a Subset of...
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...
ICG001/ICG-001/ICG 001/847591-62-2/acesobio supply
Human Gene ATF4 (ENST00000337304.2) Description and Page Index
Impaired proliferation and survival of activated B cells in transgenic mice that express a dominant-negative cAMP-response...
Browsing Chester Medical School by Authors
Targeting the NO/cGMP/CREB Phosphorylation Signaling Pathway in Alzheimers Disease | IntechOpen
THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER
Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of...
Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific,...
The versatile role of MSKs in transcriptional regulation
Transcriptional and posttranslational plasticity and the generation of inflammatory pain | PNAS
Delta-type opioid receptor - DrugBank
Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma |...
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Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality<...
CREB in cognition - Wikipedia
Frontiers | Differences in the Flexibility of Switching Learning Strategies and CREB Phosphorylation Levels in Prefrontal...
CREB
Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly Drosophila Cyclic-AMP response element binding ... The protein also has a magnesium ion that facilitates binding to DNA. The cAMP response element (CRE) is the response element ... "Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene". Nature. 328 (6126): 175-178. Bibcode ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ...
RELA
Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ... Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ...
Activating transcription factor 2
Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (1990). "A cDNA for a human cyclic AMP response element-binding protein which is ... "Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain". EMBO J. 8 (7): 2023-8. ... "Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32". Genomics. 11 ...
ICAM-1
"ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF ... These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate ... The presence of heavy glycosylation and other structural characteristics of ICAM-1 lend the protein binding sites for numerous ... ICAM-1 possesses binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 ...
Lithium (medication)
GSK-3β inhibits the transcription factors β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by ... Lithium was found to increase the basal levels of cyclic AMP but impair receptor coupled stimulation of cyclic AMP production. ... It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP production ... Over a long period of lithium treatment, cyclic AMP and adenylate cyclase levels are further changed by gene transcription ...
Adenovirus early region 1A
The structure of cyclic-AMP response element binding protein (CBP) and E1A complex was determined by NMR. It reveals that CR1 ... Early proteins typically encode non-structural proteins that are necessary for replication, whereas late structural proteins ... "The Structure of the Site on Adenovirus Early Region 1A Responsible for Binding to TATA-binding Protein Determined by NMR ... The fixed structure allows this domain to recognize TATA-binding protein (TBP) and activate transcription of certain genes. The ...
Kaang Bong-kiun
Lee JA, Kim H, Lee YS, Kaang BK (2003). "Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein- ... "AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic ... transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element-binding protein(CREB). ... he found that multiple pulses of serotonin stimulate gene expression that is mediated by the cAMP-response element(CRE). He ...
Lithium (medication)
... β-catenin and cyclic AMP (cAMP) response element binding protein (CREB), by phosphorylation. This results in a decrease in the ... Lithium was found to increase the basal levels of cyclic AMP but impair receptor coupled stimulation of cyclic AMP production.[ ... 72] It is hypothesized that the dual effects of lithium are due to the inhibition of G-proteins that mediate cyclic AMP ... Cyclic AMP secondary messengersEdit. Lithium's therapeutic effects are thought to be partially attributable to its interactions ...
Neural backpropagation
... action potentials have been shown to induce BDNF-dependent phosphorylation of cyclic AMP response element-binding protein (CREB ... This change also affects future integration of signals, leading to at least a short-term response difference between the ... boosting synaptic responses, resetting membrane potential, retrograde actions at synapses and conditional axonal output. ...
Epigenetics of depression
Cyclic-AMP response element-binding protein (CREB), which is thought to be involved in GDNF regulation, associates with the ... cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein ... CREB Binding Protein. Therefore, this antidepressant, by increasing acetylation, works to lessen the HPA response, and as a ... It is thought that this is happening due to an interaction between the response element of GR and the acetyltransferase, ...
Barrel cortex
... calmodulin-dependent protein kinase II (CaMKII) or cyclic-AMP response element binding protein (CREB). In these mice, ... Stimulation of multiple whiskers may produce a response that is equal to the sum of the responses if each whisker was ... In deprived cortex, neuronal responses to spared whiskers are enhanced and responses to deprived whiskers are weakened. These ... with the weakening of deprived response preceding the strengthening of spared response, implying that they have different ...
List of acronyms: C
Cyclic AMP-response Element Binding (protein) CREEP - (a) Committee for the Re-Election of the President, a pejorative nickname ... Cyclic Code Shift Keying CCT - (i) Current Commitments Team CCTT - (i) Close Combat Tactical Trainer cd - (s) Candela Cd - (s) ... Computer Emergency Response Team ces - (s) Czech language (ISO 639-2 code) CESS - (i) Centre for Earth Science Studies (India) ... from the chemical symbols of the two component elements) CUW - (s) Curaçao (ISO 3166 trigram) cv - (s) Chuvash language (ISO ...
Follicle-stimulating hormone receptor
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ... Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins, ...
CREB-binding protein
Parry GC, Mackman N (December 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB ... "cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response ... First isolated as a nuclear protein [Ref] that binds to cAMP-response element-binding protein (CREB), this gene is now known to ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 ( Pt 3) (3): 751-8. doi ...
CAMP responsive element modulator
Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription ... "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB ...
Molecular and epigenetic mechanisms of alcoholism
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat ... exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding ... Pandey, S.C. (2004). The gene transcription factor cyclic AMP responsive element binding protein: role in positive and negative ... cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. Alcohol Clin Exp ...
Nerve growth factor
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor.[7] Phosphorylated CREB ... GO:0001948 protein binding. • metalloendopeptidase inhibitor activity. • nerve growth factor receptor binding. • growth factor ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf.[7] Raf in turn activates ...
Nerve growth factor
... act to phosphorylate the cyclic AMP response element binding protein (CREB) transcription factor.[7] Phosphorylated CREB ... protein binding. • metalloendopeptidase inhibitor activity. • nerve growth factor receptor binding. • growth factor activity. • ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf.[7] Raf in turn activates ... Survival and PCD mechanisms are mediated through adaptor protein binding to the death domain of the p75NTR cytoplasmic tail. ...
CREB5
Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. The product of this ... cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... "Entrez Gene: CREB5 cAMP responsive element binding protein 5". Cumulated Index Medicus. U.S. Department of Health and Human ...
Luteinizing hormone/choriogonadotropin receptor
DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE), which results in the ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... G-protein coupled peptide receptor activity. • G-protein coupled receptor activity. • choriogonadotropin hormone binding. • ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ...
PFKFB3
... and progesterone response element. Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent ... N-terminal structure that secures the binding of fructose-6-phosphate to the active site via interaction with the protein's '2- ... The promoter of PFKFB3 contains binding sites, called hypoxia response elements (HREs), that recruit the binding of hypoxia- ... The PFKFB3 promoter is predicted to contain multiple binding sites, including Sp-1 and AP-2 binding sites. It also contains ...
Neurotensin
Specifically, estrogen increased cAMP activity and cAMP response element-binding protein phosphorylation in neuroblastoma cells ... modulated by estrogen in both human SK-N-SH neuroblastoma cell cultures as well as in mice through interactions with cyclic AMP ... Additionally, neurotensin gene transcription was blocked in knock-out mice lacking the RIIβ subunit of the protein kinase A ... Neurotensin is synthesized as part of a 169 or 170 amino acid precursor protein that also contains the related neuropeptide ...
Activity-regulated cytoskeleton-associated protein
7 kb upstream that contains binding sites for cyclic AMP response element-binding protein (CREB), myocyte enhancer factor 2 ( ... a serum response element (SRE; see serum response factor) at ~1.5 kb upstream of the initiation site. a second SRE at ~6.5 kb; ... The common factor for these signaling molecules involves activation of cyclic-AMP and its downstream target protein kinase A ( ... Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively. ...
CREB1
Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ... is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on ...
Neuronal memory allocation
... cyclic AMP responsive element-binding protein) in this process. Certain synapses on recruited neurons are more likely to ... The transcription factor cAMP response element-binding protein (CREB) is a well-studied mechanism of neuronal memory allocation ... Nguyen, P. V., & Woo, N. H. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...
ATF1
Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ... Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.". J. ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ...
TAF4
Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (1999). "The cyclic AMP response element ... CBX5m TATA binding protein, and Transcription initiation protein SPT3 homolog. Yeast TFIID comprises the TATA binding protein ... and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ...
Hormone receptor
Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The ... These receptors generally function via intracellular second messengers, including cyclic AMP (cAMP), cyclic GMP (cGMP), ... The features of G proteins include GDP/GTP binding, GTP hydrolysis and guanosine nucleotide exchange. When a ligand binds to a ... Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. Because of the relatively ...
CEBPB
"Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene. The protein encoded by this ... In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta ...
Eric Kandel
One of the nuclear targets for PKA is the transcriptional control protein CREB (cAMP response element binding protein).[5] In ... By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in Aplysia ganglia under conditions ... By 1980, collaboration with Paul Greengard resulted in demonstration that cAMP-dependent protein kinase, also known as protein ... The Kandel lab then sought to identify proteins that had to be synthesized to convert short-term memories into long-lasting ...
Limfocyty T regulatorowe, wolna encyklopedia
Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their ... Białko CD39 umożliwia rozkład ATP do ADP lub AMP[92]. Drugim istotnym elementem jest cząsteczka CD73, która z kolei przetwarza ... Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. „J Exp Med". 204 (6), s. 1303-1310 ... Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory ...
Prostaglandin receptor
... p38 mitogen-activated protein kinases (p38 Mpk), and cAMP response element-binding protein (CREB) which when activated ... production of cyclic AMP [cAMP]);[5] e) G proteins types to which they link and activate, i.e. those containing the Gs alpha ... G protein linkage[2]. pathways[2] Prostaglandin DP1 receptor. DP1. PGD2,,PGE2,PGF2α,PGI2=TXA2[6]. relaxant. Gs alpha subunit. ... "Prostanoid receptors - G protein-coupled receptors - IUPHAR/BPS Guide to PHARMACOLOGY". www.guidetopharmacology.org.. ...
G protein
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... Metal/element. *calcium *Calcium-binding protein. *Calmodulin-binding proteins. *copper *Ceruloplasmin. *iron *Iron-binding ... G proteins, second messengers, the enzymes that trigger protein phosphorylation in response to cAMP, and consequent metabolic ... G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside ...
Drosophila melanogaster
... and were eventually shown to encode components of an intracellular signaling pathway involving cyclic AMP, protein kinase A, ... Calcium binds to proteins such as calmodulin (CaM) and an eye-specific protein kinase C (PKC) known as InaC. These proteins ... interact with other proteins and have been shown to be necessary for shut off of the light response. In addition, proteins ... One approach of inserting foreign genes into the Drosophila genome involves P elements. The transposable P elements, also known ...
Protein kinase A
In protein synthesis, PKA first directly activates CREB, which binds the cAMP response element, altering the transcription and ... Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase was discovered by ... Cyclic+AMP-Dependent+Protein+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) ... The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts with catalytic subunit and an auto inhibitory ...
Nicotinamida adenina dinucleòtid - Viquipèdia, l'enciclopèdia lliure
Bellamacina CR «The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins». FASEB J., 10, 11, 01 ... Cyclic ADP-Ribose and NAADP: Structure, Metabolism and Functions. Kluwer Academic Publishers, 2002. ISBN 1-40207-281-3. ... és un element clau en el fà rmac isoniazida, que és utilitzat en el tractament de la tuberculosi, una infecció causada pel ... AMP) al fosfat 5' d'un extrem del DNA. Aquest intermediari és seguidament atacat pel grup hidroxil 3' de l'altre extrem de DNA ...
Transduction (physiology)
The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger ... In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. ... "Modeling of the human middle ear using the finite-element method". The Journal of the Acoustical Society of America. 111 (3): ... Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a ...
Prostaglandin DP2 receptor
... and adenyl cyclase converts AMP into cyclic AMP (cAMP) thereby down-regulating cAMP-responsive proteins involved in cell ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ... positive regulation of G-protein coupled receptor protein signaling pathway. • immune response. • neuropeptide signaling ... while arrestin-2 inhibits DP2 from further activating heterotrimeric G proteins while also linking DP2 to elements, clathrin ...
Lipid
... nuclear located protein kinase C and cyclic AMP-dependent protein kinase". Frontiers in Bioscience. 13 (13): 1206-26. doi: ... In addition to serving as a primary component of cellular membranes and binding sites for intra- and intercellular proteins, ... Hunter JE (November 2006). "Dietary trans fatty acids: review of recent human studies and food industry responses". Lipids. 41 ... Protein-lipid interaction. *Phenolic lipid, a class of natural products composed of long aliphatic chains and phenolic rings ...
Sodium-iodide symporter
... cAMP Response Element-Binding) that will bind to the CRE (cAMP Responsive Element). However, this might not occur and, instead ... binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP ... TSH first binds to its receptors which are joined to G proteins, and then induces the activation of the enzyme adenylate ... This ingested iodine is bound to serum proteins, especially to albumins.[citation needed] The rest of the iodine which remains ...
User:RostyslavZvanych/The a-ketoglutarate dehydrogenase complex in Alzheimer's disease
a b c d e f g h i j Shi, Q., Karuppagounder, S. S., Xu, H., Pechman, D., Chen, H., and Gibson, G. E. (2007) Responses of the ... It is an 8 monomer that can be divided into 4 domains; the FAD-binding domain (residues 1-149), the NAD+-binding domain ( ... Cofactor TPP and AMP are shown in cyan and blue, respectively. [17] (B) Diagram of the 12 subunit catalytic core of the cubic ... Declining protein levels were the most evident for the E1k and E2k subunits, when compared to the control. On contrary, as the ...
Substance dependence
... "cAMP response element binding protein" (CREB).[10] The nucleus accumbens (NAcc) is one brain structure that has been implicated ... "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine ... In the NAcc, CREB is activated by cyclic adenosine monophosphate (cAMP) immediately after a high and triggers changes in gene ... Dependence is defined as an adaptive state that develops in response to repeated drug administration, and is unmasked during ...
Cannabinoid receptor type 2
... cAMP response element-binding protein) to DNA.[37] This reduction causes changes in the expression of critical immunoregulatory ... "Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally ... response to amphetamine. • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger. • ... immune response. • nociception. • inflammatory response. • negative regulation of inflammatory response. • signal transduction ...
Secretin
As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP.[20] Cyclic AMP ... G-protein coupled receptor binding. • receptor binding. • protein N-terminus binding. Cellular component. • extracellular ... Secretin is released into circulation and/or intestinal lumen in response to low duodenal pH that ranges between 2 and 4.5 ... and the E-box element". Molecular Endocrinology. 18 (7): 1740-55. doi:10.1210/me.2003-0461. PMID 15118068.. ...
Actin
These proteins are called actin-binding proteins (ABP) and they are involved in actin's polymerization, depolymerization, ... Together these elements allow a spatially and temporally modulated assembly that defines a cell's response to both internal and ... "Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans". ... The most notable of these proteins are gelsolin and cofilin. These proteins first achieve a cut by binding to an actin monomer ...
Opioid receptor
The CREB protein binds to cAMP response elements CRE, and can either increase or decrease the transcription of certain genes. ... "Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system". ... This activates it, giving it the ability to catalyse substrate phosphorylation.[43] CREB (cAMP response element binding protein ... G proteins are specialised proteins whereby the nucleotides Guanosine diphosphate (GDP), and Guanosine triphosphate (GTP) bind ...
Phosphodiesterase 2
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... When cGMP binds to the allosteric GAF-B domain of the PDE, it causes conformational change in the protein structure leading to ... Furthermore, PDE2 has been indicated to play a role in inflammatory responses as it has been detected in microvessels, but not ... functional and structural elements of the active sites are very similar. The active site is formed by residues that are highly ...
Transduction (physiology)
The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger ... In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. ... Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a ... Koike, Takuji; Wada, Hiroshi; Kobayashi, Toshimitsu (2002). "Modeling of the human middle ear using the finite-element method ...
Riboswitch
... "cyclic di-GMP" below). cyclic di-AMP riboswitches (also called ydaO/yuaA) bind the signaling molecule cyclic di-AMP. cyclic di- ... including protein-free binding assays, and metabolite-binding riboswitches were established as a new mechanism of gene ... The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the ... Cobalamin riboswitch (also B12-element), which binds either adenosylcobalamin (the coenzyme form of vitamin B12) or ...
G beta-gamma complex
... and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, ... or inhibiting adenylyl cyclase leading to the intracellular increase or decrease of the secondary messenger cyclic AMP. For ... the Gβγ complex associated with a mating factor receptor-coupled G protein in yeast was found to initiate a pheromone response ... The Gβγ complex is an essential element in the GPCR signaling cascade. It has two main states for which it performs different ...
Picornain 3C
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... antiviral response. Cys24Ser (C24S) is a homolog of Hepatitis 3C proteinase, is responsible for inactivating Cys172 through ... binding protein, PABP. This disruption of this binding domain results in down regulation of the initiation of cap dependent ... P1 encodes for a proteins (VP1, VP2, VP3, and VP4) that make the capsid proteins. P2 and P3 proteins assist in infectivity of ...
Bordetella pertussis
... inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is ... The bacterium contains a surface protein, filamentous haemagglutinin adhesin, which binds to the sulfatides found on cilia of ... This is because B. pertussis inhibits the immune response, so very little mucus is generated in the lungs. A prolonged cough ... The primers used for PCR usually target the transposable elements IS481 and IS1001. Several diagnostic tests are available, ...
Minocycline upregulates cyclic AMP response element binding protein an | NDT
Keywords: vascular cognitive impairment, cAMP response element binding protein, cerebral ischamia, neuroprotection ... The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also ... Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of ... Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of ...
Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced...
Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced ... Cyclic AMP Response Element-Binding Protein/immunology. *Cyclic AMP Response Element-Binding Protein/metabolism* ... We demonstrate cAMP response element (CRE)-binding activity in CNS protein extracts and show that one of the CRE-binding ... cyclic adenosine 3,5-monophosphate (cAMP) response element-binding protein (CREB) are conserved key steps in the molecular ...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... Cyclic AMP response element-binding protein H (CREBH) was identified as a liver-specific bZIP transcription factor [10, 11]. ... The cyclic AMP response element-binding protein H (CREBH) plays important roles in hepatic lipogenesis, fatty acid oxidation, ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human ... J. H. Lee, P. Giannikopoulos, S. A. Duncan et al., "The transcription factor cyclic AMP-responsive element-binding protein H ... acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H," ... cAMP responsive element-binding protein H)," Journal of Biological Chemistry, vol. 286, no. 49, pp. 41972-41984, 2011. View at ...
Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human...
Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ... Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human ...
Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta...
Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ... Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta- ...
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene...
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ... Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene ...
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...
... report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements ( ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection ... Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. ...
Cyclic AMP Response Element-Binding Protein | Profiles RNS
Cyclic AMP Response Element-Binding Protein*Cyclic AMP Response Element-Binding Protein ... "Cyclic AMP Response Element-Binding Protein" by people in this website by year, and whether "Cyclic AMP Response Element- ... Cyclic AMP Response Element Modulator. *Cyclic AMP Response Element-Binding Protein. *Cyclic AMP Response Element-Binding ... "Cyclic AMP Response Element-Binding Protein" is a descriptor in the National Library of Medicines controlled vocabulary ...
Cyclic AMP Response Element-Binding Protein | The Chopra Library
Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor- ... the neurogenic potential of EGb 761 and its effect on cAMP response element binding protein (CREB) were examined in a double ... The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to ... CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. ...
A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of...
A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol regulation of ... title = "A role for cyclic AMP response element-binding protein (CREB) but not the highly similar ATF-2 protein in sterol ...
Frontiers | Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling | Frontiers...
Cyclic AMP Response Element-Binding Protein. Role of CREB in Axon Growth and Regeneration. During development, several ... axon growth by regulation of gene expression via the transcription factor cyclic AMP response element-binding protein (CREB; ... cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding ... and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by ...
Differential Expression of Cyclic AMP-Response Element Binding
Protein Zhangfei (CREBZF) in the Mouse...
Zhang R, Misra V. Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and ... Cyclic-Amp response element binding protein zhangfei (CREBZF) is a novel regulator of various cellular mechanisms such as ... Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal ... Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal ...
Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in...
Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in ... stim ulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein ( ...
Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit - Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA...
Cyclic AMP Response Element Binding Protein) ELISA Kit based in Delhi, India ... Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit Rat CREB(Cyclic AMP Response Element Binding Protein) ELISA Kit ... Rat CHD3(Chromodomain Helicase DNA Binding Protein 3) ELISA Kit. *Rat CHD5(Chromodomain Helicase DNA Binding Protein 5) ELISA ... Rat MBP-C/MBL2(Mannma Binding Protein C/Mannan Binding Lectin 2) ELISA Kit ...
Transcriptional regulation by cyclic AMP
The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including interme … ... Cyclic AMP / physiology* * Cyclic AMP Response Element-Binding Protein / physiology * Cyclic AMP-Dependent Protein Kinases / ... owing in large part to the characterization of cyclic AMP-responsive promoter elements, transcription factors that bind them, ... The purpose of this review is to describe the components of the cyclic AMP response unit and to analyze how these components ...
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
Genomic responses initiated by NMDA receptors (NMDARs) are critically dependent on whethe … ... Cyclic AMP Response Element-Binding Protein / metabolism* * Evoked Potentials * Hippocampus / growth & development* ... Genomic responses initiated by NMDA receptors (NMDARs) are critically dependent on whether synaptically or extrasynaptically ... Cyclic AMP Response Element-Binding Protein * Receptors, N-Methyl-D-Aspartate * Bicuculline ...
The quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain | SpringerLink
FIH, factor inhibiting HIF; CBP, cyclic AMP-response element binding protein; HRE, hypoxia response element ... However, in hypoxia, HIF-1α hydroxylation does not occur, stabilizing HIF-1 where it binds to a hypoxia response element ... Assuming an average cerebral tissue partial pressure of O2 (PcO2) of ~ 25 mmHg and lack of O2-binding proteins, the brains O2 ... As an element, oxygen (O) is unique; it is the third most abundant element in the universe after hydrogen and helium, the ...
Current Issue : Anti-Cancer Drugs
GPER | Cancer Genetics Web
Cyclic AMP Response Element-Binding Protein. *Culture Media, Conditioned. *Insulin-Like Growth Factor Binding Protein 1 ... G-protein coupled receptor activity - G-protein coupled receptor signaling pathway - Golgi membrane - hormone binding - ... The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5- ... Screening and Identification of a Phage Display Derived Peptide That Specifically Binds to the CD44 Protein Region Encoded by ...
finals - gene expression Flashcards by Estee C | Brainscape
cyclic AMP response element binding protein 73 ____ the co activator of CREB ... an example of a response element that binds to heat-specific transcription factors that are produced by elevated temperatures ... d. one transcription activator can bind to the same response element in multiple genes that each have unique promoters and ... a. consists of a single protein with two similar domains. b. Binding of TBP distorts DNA at TATA box. c. binding creates an 80 ...
Plus it
cyclic AMP response element binding protein. **Received April 21, 1998.. *Accepted July 8, 1998. ... Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by ... cAMP-dependent protein kinase. CaMKII. Ca++/CaM-dependent protein kinase II. NADPH. β-nicotinamide dinucleotide phosphate. BH4 ... These results suggest that inhibition of nNOS activity is due to direct binding of the compound to thel-arginine binding site ...
Genome-wide transcriptional profiling linked to social class in asthma | Thorax
AP1, activator protein 1; CREB, cyclic AMP response element binding protein; NFκB, nuclear factor κB; NF-Y, nuclear factor Y.. ... Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y ... Cyclic AMP response element binding protein (CREB) TFBMs were significantly less prevalent in promoters of genes overexpressed ... Regulation of asthma-related T-cell cytokines by the cyclic AMP-dependent signalling pathway. Clin Exp Allergy 2000;30:920-6. ...
Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama's disease: clinical,...
0/Cyclic AMP Response Element-Binding Protein; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 0/SMN Complex Proteins; 0/SMN1 ... Cyclic AMP Response Element-Binding Protein / genetics*. Electromyography. Female. Forearm / innervation*. Genetic ... RNA-Binding Proteins / genetics*. SMN Complex Proteins. Spain. Spinal Cord / pathology. Survival of Motor Neuron 1 Protein. ... protein, human; 0/SMN2 protein, human; 0/Survival of Motor Neuron 1 Protein; 0/Survival of Motor Neuron 2 Protein ...
Julie Glowacki, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Eco-friendly disposal of expired anti-tuberculosis drug Isoniazid and its role in the protection of metal
Cyclic AMP response element-binding protein prevents endothelial permeability.... Source: Frontiers in Pharmacology - April 24 ... Gene Ontology Analysis for Drug Targets of the Whole Genome Transcriptome of Human Vascular Endothelial Cells in Response to ... and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. Furthermore, a total of 104 ...
Full text] Neuroprotective effects of edaravone | DDDT
... phosphorylated protein kinase B; CREB, cyclic AMP response element-binding protein. ... 12 The cyclic AMP response element-binding protein (CREB), which promotes continuous plastic changes and establishment of ... while the translocation of CREB binding protein (CBP) to the promoter triggered the expression of protective proteins.12,36-38 ... The protein concentration was detected with a BCA kit, and the same amount of protein was subjected to 12% sodium dodecyl ...
Antibodies Search | ALZFORUM
CREB (cyclic-AMP response element binding protein) phosphorylated and non-phosphorylated forms.. -. ... detects cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP). -. CREB binding protein. Acris Antibodies ... detects cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP). -. CREB binding protein. Acris Antibodies ... detects cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP). -. CREB binding protein. Acris Antibodies ...
GluR1 Controls Dendrite Growth through Its Binding Partner, SAP97 | Journal of Neuroscience
2005) Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. FEBS Lett ... 2002) A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral ... family of proteins (Sheng and Sala, 2001). It has a modular organization with several protein-protein interaction domains (i.e ... GluR1 binds to SAP97, a scaffolding protein that is a component of the postsynaptic density, via its C-terminal 7 aa. We find ...
Cassiae semen: A review of its phytochemistry and pharmacology (Review)
... phosphorylated cyclic AMP response element binding protein; BDNF, brain-derived neurotrophic factor; DA, dopaminergic; MDA, ... properties and the induced upregulated expression of phosphorylated cyclic AMP response element binding protein and brain- ... sterol regulatory element-binding protein-1c, hormone-sensitive lipase and triacylglycerol hydrolase, however, tumor necrosis ... sterol regulatory element-binding protein-1c; HSL, hormone-sensitive lipase; TGH, triacylglycerol hydrolase; FAS, tumor ...
KinaseKINASESPhosphorylationGenesRegulating expression ofAdenosineActivatesCellsResponsive elementCREB-BindingTranscription factor that bindsActivationCellularApoptosisRegulationNucleotideDimersRegulatesInhibitionBasic leucine-zipperBZIP proteinsReceptorsReceptorFamily of proteins includesMoleculeLeucine zipper familyStimulationIntracellularExpressionPathwayDimerizationPromotersSequenceMembraneSerinePutativeCharacterizationRegulatorDownstreamMeSHNeuronsCREB1MediateNuclearPromoter regionMammalianCAMP respons1999RoleModulatorInductionUniProt
Kinase33
- CREB phosphorylation involved c-Src-dependent extracellular signal-regulated kinase 1/2 activation, but not protein kinase A,prot ein kinase C,or calmodulin-dependent kinase II,and occurred also in cells transfected with AR or estrogen receptor mutants that do not localize into the nucleus. (unict.it)
- SAP97 is the mammalian homolog of the Drosophila discs-large tumor suppressor and is a member of the MAGUK (membrane-associated guanylate kinase) family of proteins ( Sheng and Sala, 2001 ). (jneurosci.org)
- Findings with a different protein, alpha-CaM kinase II, demonstrated the chemical's ability to erase both short-term and long-term fear memories in a very targeted fashion. (dana.org)
- Joe Tsien and colleague conditioned fear in mice, and then successfully deleted the fear memories by overexpressing the protein alpha-CaM kinase II. (dana.org)
- 2 During the embryonic stage, the animals were injected with a DNA molecule that caused their brains (when fully developed) to constantly overexpress a protein called alpha-CaM kinase II. (dana.org)
- The solution structure of the complex formed by the phosphorylated kinase-inducible domain (pKID) of CREB with KIX reveals that pKID undergoes a coil-->helix folding transition upon binding to KIX, forming two alpha helices. (rcsb.org)
- The first kinase identified as being responsible for the phosphorylation of serine 133 is a cAMP-dependent protein kinase (protein kinase A [PKA]), which is activated by an increase in the intracellular cAMP level. (ahajournals.org)
- 15 This transcription factor is activated by phosphorylation of Ser133 residue, which is typically performed by protein kinase A. 16 However, other protein kinases such as extracellular signal-regulated kinases 1/2 (ERK1/2), p38 mitogen-activated protein kinase (p38MAPK), calmodulin kinase (CaMK), and protein kinase B (PKB) have also been shown to phosphorylate and activate CREB. (ahajournals.org)
- Utilizing loss- and gain-of-function approaches in cultured epithelia and murine colonoids, we demonstrate that EA elicits prominent CREB phosphorylation through cyclic AMP-independent mechanisms that requires elements of the mitogen-activated protein kinase signaling pathway. (genengnews.com)
- Previous studies have shown a cAMP/protein kinase A-dependent neuroprotective effect of adenosine on glutamate or re-feeding-induced apoptosis in chick retina neuronal cultures. (semanticscholar.org)
- One such transcription factor is the cAMP-regulatory element-binding protein (CREB), which can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, and calcium/calmodulin-dependent kinases and regulates genes whose deregulated expression promotes oncogenesis, including cyclins , Bcl-2 family members, and Egr-1 . (aacrjournals.org)
- Signal transduction abnormalities in cancer mitogen-activated protein kinase regulation is altered in breast cancer. (jci.org)
- Hyperexpression of mitogen-activated protein kinase in human breast cancer. (jci.org)
- Mitogen-activated protein (MAP) kinases act as transducers of extracellular signaling via tyrosine kinase-growth factor receptors and G-protein-linked receptors to elements regulating transcription. (jci.org)
- In spite of persistent activation via phosphorylation, MAP kinase expression is upregulated 5-20-fold and this hyperexpression may be a critical element to initiation as well as the metastatic potential of various forms of human breast cancer. (jci.org)
- Triggered by lipopolysaccharide (LPS), protein kinase A (PKA) specifically phosphorylates serine 276 in the RHD domain in the cytoplasm, controlling NF-κB DNA-binding and oligomerization. (wikipedia.org)
- On the other hand, mitogen and stress-activated kinase 1 (MSK1) are also able to phosphorylate RELA at residue 276 under TNFα induction in the nucleus, increasing NF-κB response at the transcriptional level. (wikipedia.org)
- Phosphorylation of serine 311 by protein kinase C zeta type (PKCζ) serves the same purpose. (wikipedia.org)
- In response to DNA damage, ribosomal subunit kinase-1 (RSK1) also has the ability to phosphorylate RELA at serine 536 in a p53-dependent manner. (wikipedia.org)
- Selective interaction of JNK protein kinase isoforms with transcription factors. (nii.ac.jp)
- In both phases, inhibition of cAMP-dependent protein kinase A (PKA) activity prevented ethanol-induced CRE-mediated luciferase expression. (aspetjournals.org)
- 2015 ) protein kinase activates ATF2 (Bhoumik et al. (springer.com)
- Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression. (springer.com)
- The cAMP-protein kinase A (PKA) pathway is an important intracellular signal transduction cascade that can be activated by a large variety of stimuli. (kuleuven.be)
- Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. (nih.gov)
- 1997) . DAG activates protein kinase C (PKC) (Riedel et al. (supermemo.com)
- 1992b) that leads to increased levels of cAMP that migrates to the cell nucleus, activates protein kinase A (PKA) and triggers gene expression (Hagiwara et al. (supermemo.com)
- Cyclic AMP-dependent protein kinases ( protein kinase A ) are activated by the signal chain coming from the G protein (that was activated by the LHCG-receptor) via adenylate cyclase and cyclic AMP (cAMP). (bionity.com)
- The aim of this study was to determine if estrogens could directly modulate signalling pathways within bladder sensory neurons, such as extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases. (biomedcentral.com)
- Phosphorylation of ATF1 at Ser63 by PKA (cAMP-dependent protein kinase) and related kinases was the only known post-translational regulatory mechanism of ATF1. (biologists.org)
- Here, we found that HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase that phosphorylates Ser198 but not Ser63. (biologists.org)
- Stimulus-coupled activation of ATF1 is induced by growth factors as well as stress-inducing agents, in which ATF1 is phosphorylated at Ser63 located in the kinase-inducible (KID) domain by PKA (cAMP-dependent protein kinase) and several other serine-threonine (Ser-Thr) kinases ( Mayr and Montminy, 2001 ). (biologists.org)
- To better understand the ATF1-mediated ARE regulation, in this study we attempted to find ATF1-interacting proteins by yeast two-hybrid screening and have identified homeodomain-interacting protein kinase 2 (HIPK2) as an ATF1 binding protein. (biologists.org)
KINASES6
- A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. (childrensmercy.org)
- Protein kinases and transcription factors transmit the signals from the external stimuli to the genome, resulting in the modification of gene expression profile of the cells to accommodate to the environmental changes. (ahajournals.org)
- The fact that RELA can be modified by a collection of kinases via phosphorylation at different sites/regions within the protein under different stimulations might suggest a synergistic effect of these modifications. (wikipedia.org)
- Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (reactome.org)
- These protein kinases are present as tetramer with two regulatory units and two catalytic units. (bionity.com)
- These proteins are typically activated through phosphorylation by the indicated upstream kinases. (pubmedcentralcanada.ca)
Phosphorylation16
- Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced phosphorylation. (nih.gov)
- The phosphorylation and the binding to DNA of the nuclear transcription factor, cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) are conserved key steps in the molecular cascade leading to the formation of long-term memory (LTM). (nih.gov)
- Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor/cyclic AMP mechanism. (aspetjournals.org)
- In the present study the effects of NE on the phosphorylation of the cAMP response element-binding protein (CREB) were studied to determine whether CREB phosphorylation might be involved in cAMP signal transduction in this tissue. (aspetjournals.org)
- This antiserum generates a supershifted CREB signal with protein extracts obtained from glands treated with NE (EC50 approximately equal to 10 nM) in organ culture, demonstrating that NE stimulates CREB phosphorylation. (aspetjournals.org)
- 5 On phosphorylation at serine 133, the CREB binding protein (CBP) is recruited to CREB. (ahajournals.org)
- Phosphorylation at these sites enhances NF-κB transcriptional response via tightened binding to transcription coactivators. (wikipedia.org)
- In vivo studies revealed that RELA is also under acetylation modification in the nucleus, which is just as important as phosphorylation as a post-translational modification of proteins. (wikipedia.org)
- We have shown in the NG108-15 neuroblastoma × glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A 2 receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB). (aspetjournals.org)
- However, phosphorylation of CREB is not sufficient to activate cAMP response element (CRE)-mediated gene expression. (aspetjournals.org)
- Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. (kegg.jp)
- 1989 ). The ATF2 protein consists of 505 amino acids, with phosphorylation sites near the C-terminus at serine residues 472 and 480 in the mouse protein and serine residues 490 and 498 in the human protein. (springer.com)
- ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. (springer.com)
- Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. (uniprot.org)
- Upon binding of cAMP to the regulatory units, the catalytic units are released and initiate the phosphorylation of proteins leading to the physiologic action. (bionity.com)
- Immunostaining was also used to examine phosphorylation of cyclic AMP response element binding protein (CREB). (elsevier.com)
Genes26
- The promoter elements of many monocyte-specific genes contain C/EBP binding sites, including macrophage inflammatory protein 1 alpha, tumor necrosis factor alpha ( 32 ), IL-6 ( 6 , 27 , 38 ), and IL-8 ( 27 , 36 ). (asm.org)
- Transcription of many genes is directed by the cAMP/Ca(2+)-responsive element (CRE) and its cognate transcription factor CRE-binding protein (CREB). (aspetjournals.org)
- Sterol regulatory element-binding proteins (SREBPs) activate promoters for key genes of metabolism to keep pace with the cellular demand for lipids. (elsevier.com)
- RNA pol II transcribes all protein coding, snoRNA and snRNA genes d. (brainscape.com)
- Children with asthma from a low SES background showed overexpression of genes regulating inflammatory processes, including those involved in chemokine activity, stress responses and wound responses, compared with children with asthma from a high SES background. (bmj.com)
- 11 12 Another social factor associated with low SES-stress-has been linked to heightened inflammatory responses to allergen challenge in patients with asthma, 13 and decreased expression of genes coding hormonal receptors that regulate inflammation, including the glucocorticoid and β adrenergic receptors. (bmj.com)
- The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. (abcam.com)
- Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. (genecards.org)
- Processed cyclic AMP-responsive element-binding protein 3: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. (genecards.org)
- CREB (cAMP response element-binding protein) [1] is a cellular transcription factor that binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. (wikiversity.org)
- Within the cAMP-responsive element of the somatostatin gene, we observed an 8-base palindrome, 5'-TGACGTCA-3', which is highly conserved in many other genes whose expression is regulated by cAMP. (wikiversity.org)
- Cells change the expression pattern of genes in response to extracellular signals. (ahajournals.org)
- To obtain insights into the molecular mechanisms of this response a systematic genetic screen was performed to identify genes that when overexpressed can induce a starvation-like response in the yeast species Schizosaccharomyces pombe . (asm.org)
- The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes. (wikipedia.org)
- Thus, critical insight into the role of transcription factor activation in cancer arose from studying the regulation of genes in response to cytokines under normal conditions. (aacrjournals.org)
- Typical enhancers of viral or cellular genes are approximately 100 to 400 bp long and contain several transcription factor binding sites. (asm.org)
- We show here that ethanol exposure causes a striking increase in CRE- and CREB-mediated gene expression in cells transfected with luciferase reporter genes and that PKA and CREB are required for this response. (aspetjournals.org)
- CREB triggers a gene expression cascade with a group of IEGs coding for transcription factors such as zif/268, c-fos, c-jun, junB, and junD that in turn lead to transcription of late effector genes coding for proteins critical for establishing long-term memory (Abraham et al. (supermemo.com)
- These results suggest that, in addition to its role as a transcription factor for the expression of replication genes, Mcm1 may influence the local structure of replication origins by direct binding. (labome.org)
- Previously, we used P -element mutagenesis and quantitative trait locus (QTL) mapping in Drosophila to identify candidate genes affecting resistance to starvation stress, and variation in resistance to starvation stress between the Oregon-R (Ore) and 2b strains. (biomedcentral.com)
- Nearly 50% of P -element insertions in 160 genes with altered transcript abundance during starvation stress had mutational effects on starvation tolerance. (biomedcentral.com)
- MicroRNAs originate from inter-and intragenic sites including introns of protein-coding genes and their own specific gene loci. (pubmedcentralcanada.ca)
- DNA in the cell nucleus binds to phosphorylated proteins through the cyclic AMP response element (CRE) which results in the activation of genes . (bionity.com)
- ATF1 and CREB control transcription of many target genes through homo- or heterodimerization within the family or with other b-zip transcription factors on the sequences related to an AP1 or cAMP-response element ( Mayr and Montminy, 2001 ). (biologists.org)
- Alberini and M.D./Ph.D. student Stephen M. Taubenfeld suspected that CREB protein depends on certain consolidation-related genes from within the region of the brain known as the hippocampus (injuries to this area often result in amnesia). (brownalumnimagazine.com)
- Next, she says, is figuring which genes the protein switches on. (brownalumnimagazine.com)
Regulating expression of1
- Hepatocyte nuclear factor 4 α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H," Hepatology , vol. 48, no. 4, pp. 1242-1250, 2008. (hindawi.com)
Adenosine7
- [2] CREB was first described in 1987 as a cyclic adenosine monophosphate (cAMP)-responsive transcription factor regulating the somatostatin gene. (wikiversity.org)
- During episodes of inflammation, multiple cell types release adenine nucleotides in the form of ATP, ADP, 5′-AMP, and adenosine. (jimmunol.org)
- Extracellular 5′-AMP is metabolized to adenosine by surface-expressed 5′-ectonucleotidase (CD73). (jimmunol.org)
- Initial experiments revealed that adenosine and adenosine analogues induce CD73 mRNA (RT-PCR), surface expression (immunoprecipitation of surface biotinylated CD73), and function (HPLC analysis of etheno-AMP conversion to ethenoadenosine) in a time- and concentration-dependent fashion. (jimmunol.org)
- For instance, in epithelia and endothelia, cell surface CD73 converts AMP into adenosine, which when released can activate seven-transmembrane-spanning adenosine receptors ( 3 , 4 ) or can be internalized through dipyridamole-sensitive carriers ( 5 ). (jimmunol.org)
- 5′-AMP is rapidly converted to adenosine (via surface-expressed CD73), and adenosine liberated in this fashion directly activates surface adenosine A 2B receptors ( 4 , 7 , 10 ) and promotes endothelial barrier function through elevation of intracellular cAMP ( 4 , 11 ). (jimmunol.org)
- Adenosine-3',5'-cyclic monophosphate (cyclic AMP) is a second messenger that plays an important role in intracellular regulation. (biovendor.com)
Activates4
- Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). (genecards.org)
- MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). (kegg.jp)
- Upon binding LH externally to the membrane, a transduction of the signal takes place that activates the G protein that is bound to the receptor internally. (bionity.com)
- With LH attached, the receptor shifts conformation and thus mechanically activates the G protein, which detaches from the receptor and activates the cAMP system. (bionity.com)
Cells27
- Recent observations have shown two CCAAT/enhancer binding protein (C/EBP) binding sites to be critically important for efficient human immunodeficiency virus type 1 (HIV-1) replication within cells of the monocyte/macrophage lineage, a cell type likely involved in transport of the virus to the brain. (asm.org)
- Additional studies indicated that these two C/EBP binding sites were required for replication of an infectious HIV-1 molecular clone in the U-937 cell line as well as in primary cells of the monocyte/macrophage lineage. (asm.org)
- While C/EBP proteins are expressed in many human tissues, high levels of C/EBP mRNA and protein expression are limited to only a few cell types, including cells of the myeloid lineage. (asm.org)
- Some of these putative co-regulatory proteins are members of transcription factor families that all bind to the same DNA sequence elements in vitro and are often expressed in the same cells. (elsevier.com)
- We have used the chromatin immunoprecipitation (ChIP) technique coupled with a transient complementation assay in Drosophila SL2 cells to directly compare the ability of two members of the CREB/ATF family to function as co-regulatory proteins for SREBP-dependent activation of the HMG-CoA reductase promoter. (elsevier.com)
- Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors. (ksdb.org)
- We now show that,in prostate cancer cells,stim ulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein (CREB) activation. (unict.it)
- This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. (cancerindex.org)
- We evaluated the effects of ESAT-6 and its molecular chaperone, culture filtrate protein of 10 kDa (CFP10), on the capacity of human T cells to produce IFN-γ and proliferate in response to TCR activation. (jimmunol.org)
- ESAT-6, but not CFP10, bound to T cells and inhibited expression of early activation markers without reducing activation of ZAP70. (jimmunol.org)
- Since normal cells are relatively insensitive to inhibition of these proteins due to redundancies in normal signaling pathways, inhibitors of these transcription factors hold the potential for having a very high therapeutic index. (aacrjournals.org)
- Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH (2011) The role of colorectal cancer stem cells in metastatic disease and therapeutic response. (springer.com)
- Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (FC epsilonRI) on the surface of mast cells with multivalent allergens results in the release of both pre-formed and newly generated mediators, and in the manifestation of allergic symptoms. (jci.org)
- For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells. (wikipedia.org)
- Kang Y, Chen CR, Massague J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. (springer.com)
- We analyzed bioinformatics data and identified three TFs, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), cyclic AMP response element binding protein (CREB), and hypoxia-inducible factor-1α (HIF-1α), that are highly active in tumor cells. (biomedcentral.com)
- Differences in transcriptional responses to the PKA pathway and other CREB-regulating stimuli between cells, tissues, and even organisms can be partially attributed to the presence of different CREB isoforms. (kuleuven.be)
- Pinto M, Howell R. Concomitant quantification of targeted drug delivery and biological response in individual cells. (labome.org)
- We had previously shown that the bLZip domain-containing transcription factor, Zhangfei/CREBZF inhibits the growth and the unfolded protein response (UPR) in cells of the D-17 canine osteosarcoma (OS) line and that the effects of Zhangfei are mediated by it stabilizing the tumour suppressor protein p53. (biomedcentral.com)
- MicroRNAs function at a posttranscriptional level to fine-tune protein levels in cells. (pubmedcentralcanada.ca)
- This has the effect of promoting degradation or inhibiting translational efficiency, leading to overall lower protein levels in cells ( 6 ). (pubmedcentralcanada.ca)
- In rod cells, 11- cis -retinal binds to a protein called opsin to form the visual pigment rhodopsin (also known as visual purple). (oregonstate.edu)
- The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1. (freepatentsonline.com)
- We have previously demonstrated that quenching of CREB-associated proteins in metastatic melanoma cells by a dominant-negative CREB (KCREB) that is mutated within its DNA-binding decreased their radiation resistance, and their tumorigenic and metastatic potential in nude mice. (elsevier.com)
- We did not observe any changes in Bcl-2 or Bcl-2-related proteins (Bcl-x, Bax, and Bad) in control or KCREB-transfected cells before or after treatment with Tg. (elsevier.com)
- Collectively, these data indicate that CREB and its associated proteins act as survival factors for human melanoma cells, and hence contribute to the acquisition of the malignant phenotype. (elsevier.com)
- A) ALP activity in C2C12 cells, treated with PTH at 0 to 200 nM for 24 hours, was measured with normalization by cell proteins. (nih.gov)
Responsive element6
- The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism," Nature Medicine , vol. 17, no. 7, pp. 812-815, 2011. (hindawi.com)
- Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H)," Journal of Biological Chemistry , vol. 286, no. 49, pp. 41972-41984, 2011. (hindawi.com)
- RATIONALE: The transcription factor cAMP responsive element-binding protein 1 (CREB1) has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. (isharonline.org)
- CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. (genecards.org)
- cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. (wikipedia.org)
- The cyclic (c)AMP responsive element binding protein (CREB) plays a key role in many cellular processes, including differentiation, proliferation, and signal transduction. (aacrjournals.org)
CREB-Binding2
- OBJECTIVE: The present study assessed the role of striatal CREB1 and its coactivator CREB-binding protein (CBP) in behavioural responses to psychostimulants. (isharonline.org)
- Researchers led by Salvatore Oddo at the University of Texas in San Antonio found that plying Alzheimer's disease model mice with CREB binding protein (CBP) rescued learning in these mice without altering Aβ or tau levels. (alzforum.org)
Transcription factor that binds1
- This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. (wikipedia.org)
Activation11
- Most importantly, sequence variation at the ATF/CREB binding site affected basal LTR activity as well as LTR function following interleukin-6 stimulation, a treatment that leads to increases in C/EBP activation. (asm.org)
- vi) electrolyte and temperature rebalance, (vii) increased production of reactive oxygen species (ROS) and reactive oxygen nitrogen species (RONS), vii) activation of the sympatho-adreno-medullary and hypothalamus-pituitary-adrenal (HPA) axes, which results in the release of stress hormones into these circulatory system (reviewed by Clark and Mach, 2016 ) as well as systemic inflammation and immune responses ( Mach and Fuster-Botella, in press ). (frontiersin.org)
- In particular, following activation, polymorphonuclear leukocytes release larger quantities of 5′-AMP. (jimmunol.org)
- Analysis of DNA-binding activity by EMSA identified a functional role for CD73 cAMP response element and, moreover, indicated that multiple cAMP agonists induce transcriptional activation of functional CD73. (jimmunol.org)
- RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation. (wikipedia.org)
- RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (wikipedia.org)
- Ebrahimian T, Dierick F, Simon D, Heidari M, Orthwein A, Mann KK, Lehoux S. FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response. (harvard.edu)
- HER-2/neu overexpression resulted in the induction and activation of CREB protein in vitro and in vivo , whereas short hairpin RNA (shRNA)-mediated inhibition of HER-2/neu correlated with downregulated CREB activity. (aacrjournals.org)
- cAMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1), members of the CREB/ATF family, have been implicated in cAMP- and calcium-induced transcriptional activation. (elsevier.com)
- When the researchers looked directly at the hippocampus, they found that normal animals averaged a 152 percent increase in CREB protein activation, but CREB levels in the forgetful animals were flat. (brownalumnimagazine.com)
- Remarkably, 5-HT4 receptor agonists are also reported to induce neurogenesis in hippocampus as well as enteric system through the activation of cyclic AMP response element binding protein in rodents. (scirp.org)
Cellular12
- Thus, HIV-1 LTR ATF/CREB binding site sequence variation may modulate cellular signaling at the viral promoter through the C/EBP pathway. (asm.org)
- To induce axon extension, the cellular machinery at the nerve growth cone controls the assembly of cytoskeletal proteins and membrane components into new axons. (frontiersin.org)
- The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including intermediary metabolism, cellular proliferation, and neuronal signaling, by altering basic patterns of gene expression. (nih.gov)
- Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. (genecards.org)
- Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. (genecards.org)
- CREB was originally isolated as a gene regulatory protein that bound to the CRE site of the somatostatin gene promoter region in response to an increase in the cellular cAMP level. (ahajournals.org)
- Hai T. The ATF transcription factors in cellular adaptive responses. (springer.com)
- ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component? (springer.com)
- These results indicate that SSRP1 is a novel cellular protein involved in LANA-dependent DNA replication. (labome.org)
- Their effects are particularly important for reducing "noise" and conferring precision to cellular protein levels, particularly for low-abundance targets ( 7 , 8 ). (pubmedcentralcanada.ca)
- Activator protein 1 (AP1) 1 , 2 functions in almost all areas of eukaryotic cellular behaviour, from cell cycle proliferation and development to stress response and apoptosis. (pubmedcentralcanada.ca)
- This inherently diverse composition of AP1 complexes and their central role in transcriptional regulation places AP1 complexes at a functional epicenter for pathological signal relay in disease, particularly in the context of malignant cellular transformation in which AP1 proteins are often deregulated by oncoprotein signalling 4 - 6 . (pubmedcentralcanada.ca)
Apoptosis1
- As the induction of apoptosis by diverse exogenous signals is dependent on the elevation of intracellular Ca 2+ , the purpose of this study was to determine the role of CREB and its associated proteins in apoptosis using KCREB. (elsevier.com)
Regulation7
- In fact, C/EBP proteins are intimately involved in the regulation of myelocytic/monocytic gene expression. (asm.org)
- Axon growth requires the coordinated regulation of gene expression in the neuronal soma, local protein translation in the axon, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. (frontiersin.org)
- The results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation (p (cancerindex.org)
- cAMP response element binding protein (CREB) has been implicated in the regulation of VSMC growth and motility in response to thrombin and angiotensin II. (ahajournals.org)
- cAMP-response element-binding protein (CREB) belongs to the basic leucine-zipper family of transcriptional factors that were shown to play an important role in gene regulation, particularly in response to cAMP. (ahajournals.org)
- Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP. (biovendor.com)
- This review will mainly focus on the presence and regulation of CREB proteins in insects. (kuleuven.be)
Nucleotide1
- An unusual result was that the conserved nucleotide at position 6 did not significantly affect in vitro binding of the complex. (labome.org)
Dimers4
- In addition, CREB-1 homodimers bind to the ATF/CREB site and recruit C/EBP dimers to their cognate weak binding sites. (asm.org)
- The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. (bionity.com)
- The different AP1 dimers bind to DNA with varying affinities and differ in their transactivation efficiencies 8 , 15 . (pubmedcentralcanada.ca)
- Jun proteins can form stable dimers that bind to the AP1 DNA recognition element 5′-TGAC/GTCA-3′ (also known as TPA response element (TRE)) based on their ability to mediate transcriptional induction in response to the phorbol ester tumour promoter TPA 2 , 15 . (pubmedcentralcanada.ca)
Regulates3
- This protein binds to the cAMP-response element and regulates cell proliferation. (genecards.org)
- Activating transcription factor 2 (ATF2) down-regulates hepatitis B virus X promoter activity by the competition for the activating protein 1 binding site and the formation of the ATF2-Jun heterodimer. (springer.com)
- Their results revealed that the circulating protein growth differentiation factor 11 (GDF11), which regulates the growth of spinal and olfactory (smell) receptors, is produced abundantly in young mice, but production drops off with age. (jax.org)
Inhibition5
- Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription. (aspetjournals.org)
- These results suggest that inhibition of nNOS activity is due to direct binding of the compound to the l -arginine binding site of the synthase. (aspetjournals.org)
- In vitro studies showed that SVP conditioned medium stimulates endothelial tube formation and reduces myofibroblast differentiation, through inhibition of Ras-GTPase activating protein and methyl-CpG-binding protein 2, which are validated miR-132 targets. (ahajournals.org)
- Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. (nih.gov)
- After stable binding, other proteins may be recruited to the RISC, which promotes degradation or translational inhibition ( 13 ). (pubmedcentralcanada.ca)
Basic leucine-zipper3
- Since CREB is a basic leucine zipper (bZip) protein, other insect members of this important family of transcriptional regulators will be briefly discussed as well. (kuleuven.be)
- The dimeric combinations and transcriptional activity observed in vivo are largely influenced by the tissue-specific expression patterns of the individual proteins, and importantly by their specific activating mechanisms and post-translational modifications that facilitate their individual ability to dimerize with other basic leucine zipper (bZIP) domain proteins. (pubmedcentralcanada.ca)
- AP1 constituent proteins are structurally distinguished by a basic leucine zipper (bZIP) domain that is composed of leucine zipper and basic domains. (pubmedcentralcanada.ca)
BZIP proteins2
- Kerppola TK, Curran T. Selective DNA bending by a variety of bZIP proteins. (childrensmercy.org)
- Transcription factors 1: bZIP proteins. (springer.com)
Receptors1
- The binding of LH (or CG) to the receptor shifts the equilibrium between active and inactive receptors. (bionity.com)
Receptor10
- X. Prieur, H. Coste, and J. C. RodrÃguez, "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor- α and contains a novel farnesoid X-activated receptor response element," Journal of Biological Chemistry , vol. 278, no. 28, pp. 25468-25480, 2003. (hindawi.com)
- This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. (cancerindex.org)
- Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. (cancerindex.org)
- Ultrasound-targeted microbubble destruction of calcium channel subunit α 1D siRNA inhibits breast cancer via G protein-coupled receptor 30. (cancerindex.org)
- Further analysis revealed that EA signals through the G protein-coupled receptor GPR31 to promote induction of FosB, NR4A1, and DUSP1. (genengnews.com)
- Allegra CJ, Rumble RB, Hamilton SR, Mangu PB, Roach N, Hantel A, Schilsky RL (2016) Extended RAS gene mutation testing in metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy: American Society of Clinical Oncology provisional clinical opinion update 2015. (springer.com)
- microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia. (springer.com)
- The luteinizing hormone/choriogonadotropin receptor ( LHCGR ), also lutropin/choriogonadotropin receptor ( LCGR ) is a transmembrane receptor that interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). (bionity.com)
- Total dopaminergic receptor binding parameter, B max showed an increase in cerebral cortex and decrease in the cerebellum of diabetic rats. (biomedcentral.com)
- In various cell based and animal models, partial 5-HT4 receptor agonists are demonstrated to promote the release of soluble amyloid precursor protein alpha and block the release of amyloid beta peptide offering suitable candidates as disease modification agents. (scirp.org)
Family of proteins includes1
- The C/EBP family of proteins includes at least eight different proteins, many of which are important activators of transcription. (asm.org)
Molecule1
- 2018 ). Thus, we can thank our (dying) lucky stars, the burning crucibles that convert hydrogen and helium into heavier elements for our O 2 , the molecule that made our world, our brains and us. (springer.com)
Leucine zipper family2
- This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. (abcam.com)
- Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins located on human chromosome 2q32 and was discovered by Maekawa et al. (springer.com)
Stimulation2
- The purpose of this review is to describe the components of the cyclic AMP response unit and to analyze how these components cooperate to induce target gene expression in response to hormonal stimulation. (nih.gov)
- Moreover, microRNA-132 (miR-132) was constitutively expressed and secreted by SVPs and remarkably upregulated, together with its transcriptional activator cyclic AMP response element-binding protein, on stimulation by H/S or vascular endothelial growth factor B. We next investigated if SVP-secreted miR-132 acts as a paracrine activator of cardiac healing. (ahajournals.org)
Intracellular3
- The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. (cancerindex.org)
- ATF1 is a transcriptional repressor of ferritin H, the major intracellular iron storage gene, through an ARE (antioxidant-responsive element). (biologists.org)
- Ferritin is the major intracellular iron storage protein comprising 24 subunits of H and L forms ( Theil, 2003 ). (biologists.org)
Expression30
- This work establishes the expression of a highly conserved functional CREB1-like protein in the CNS of Lymnaea and opens the way for a detailed analysis of the role of CREB proteins in LTM formation in this model system. (nih.gov)
- Moreover, it was shown that CREBH directly regulated human APOA5 gene expression by binding to a unique CREBHRE located in the proximal human APOA5 promoter region, using 5′-deletion and mutagenesis of human APOA5 promoter analysis and chromatin immunoprecipitation assay. (hindawi.com)
- CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression," Nucleic Acids Research , vol. 29, no. 10, pp. 2154-2162, 2001. (hindawi.com)
- Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. (semanticscholar.org)
- SMA is caused by a mutation of the survival-of-motor-neuron 1 (SMN1) gene, leading to a quantitative defect in the survival-motor-neuron (SMN) protein expression. (isharonline.org)
- Confocal imaging analysis indicated that the protein expression of CREBZF in seminiferous tubule remained low until postnatal day (PD) 14, and was dramatically increased in PD 21. (ksdb.org)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- ESAT-6 decreased IFN-γ transcription and reduced expression of the transcription factors, ATF-2 and c-Jun, which normally bind to the IFN-γ proximal promoter and stimulate mRNA expression. (jimmunol.org)
- The expression of mBDNF/TrkB/PI3K pathway-related proteins was detected by Western blot and quantitative reverse transcription-polymerase chain reaction (q-RT PCR). (dovepress.com)
- Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. (genecards.org)
- Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression. (genecards.org)
- CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. (wikiversity.org)
- Serial 5′ deletions and site-directed mutagenesis of IL-6 promoter along with chromatin immunoprecipitation using anti-CREB antibodies showed that cAMP response element is essential for 15(S)-HETE-induced IL-6 expression. (ahajournals.org)
- Adenovirus-mediated transduction of 15-lipoxygenase 2 (15-LOX2) caused increased production of 15-HETE in VSMCs and enhanced IL-6 expression, SMC migration from media to intimal region, and neointima formation in response to arterial injury. (ahajournals.org)
- Adaptive responses, including changes in gene expression in neurons, are thought to account for some of these complex behavioral abnormalities. (aspetjournals.org)
- Coexpression of a dominant-negative CREB construct blocked ethanol-stimulated CRE-luciferase expression, further suggesting that CREB is required for this response. (aspetjournals.org)
- Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. (usf.edu)
- Reverse transcription polymerase chain reaction, western blotting and cell transfection were applied for the measurement of mRNA, protein expression and activity. (biomedcentral.com)
- To establish a mechanistic link between HER-2/neu-mediated transformation and CREB protein expression and function, in vitro models of HER-2/neu-overexpressing and HER-2/neu-negative/silenced counterparts as well as human mammary carcinoma lesions with defined HER-2/neu status were used. (aacrjournals.org)
- Expression profiling in ALL: We are examining gene expression profiles in acute lymphoblastic leukemia in response to chemotherapeutic agents. (stanford.edu)
- Guo Y, Breeden L, Zarbl H, Preston B, Eaton D. Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. (labome.org)
- The CCAAT enhancer binding protein beta (C/EBP-β) increased the expression of miR-16 after I/R injury. (nature.com)
- The ChIP and luciferase promoter assay indicated that about −1.0 kb to −0.5 kb upstream of miR-16 genome promoter region containing C/EBP-β binding motif transcriptionally regulated miR-16 expression. (nature.com)
- No studies investigating the function of C/EBP-β in the kidney have been reported except for the ER stress induced renal C/EBP-β and the suppression of NF-κB-dependent gene expression in response to LPS in mice 17 . (nature.com)
- T0901317, a synthetic LXR ligand, decreased AT1R mRNA and protein expression with a peak reduction at 6 hours and 12 hours of incubation, respectively. (ahajournals.org)
- 3,4 Expression of these ABC proteins is increased by LXR agonists. (ahajournals.org)
- We tested the hypothesis that queen mandibular pheromone (QMP) causes changes in gene expression in the brain of the adult worker honey bee, and that these changes can be correlated to the downstream behavioral responses induced by QMP. (pnas.org)
- MicroRNAs exert network-level effects on gene expression because each can target multiple transcripts that encode proteins in the same pathway or single targets in multiple pathways. (pubmedcentralcanada.ca)
- 20. The expression system of claim 1, wherein the neuron-specific regulatory element is the synapsin promoter as set forth in FIG. 8 beginning at position 7 and ending at position 488. (freepatentsonline.com)
- Radioreceptor binding assays and gene expression was done in the cerebral cortex and cerebellum of male Wistar rats using specific ligands and probes. (biomedcentral.com)
Pathway3
- Although transcriptional mechanisms responsible for these effects are not fully understood, it is recognized that transcriptional factor cAMP response element binding protein (CREB) mediates PTH signaling in osteoblasts, and that there is a communication between the PTH-CREB pathway and the BMP2 signaling pathway, which is important for osteoblast differentiation and bone formations. (nih.gov)
- These findings, in conjunction with putative cAMP response elements (CREs) in the BMP2 promoter, led us to hypothesize that the PTH-CREB pathway could be a positive regulator of BMP2 transcription in osteoblasts. (nih.gov)
- Using genome-wide microarray analysis of the hippocampus combined with Ingenuity Pathway Analysis (IPA), they identified a potential factor, cyclic AMP response element binding protein (CREB), that may be involved. (jax.org)
Dimerization4
- Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. (childrensmercy.org)
- bZIP contains the basic region and the leucine zipper important for DNA binding and dimerization, respectively. (ahajournals.org)
- RHD is involved in DNA binding, dimerization and NF-κB/REL inhibitor interaction. (wikipedia.org)
- One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity. (springer.com)
Promoters3
- Two other members of this family of proteins, chromogranin B and secretogranin II (also known as chromogranin C), contain similar CRE and TATA homologies in their proximal gene promoters (8, 9). (wikiversity.org)
- The term ATF was first used in 1987 to refer to a putative polypeptide with the activity to bind to the sites on the adenovirus E2, E3, and E4 promoters with sequences similar to the consensus TGACGT(C/A)(G/A) (Lee et al. (springer.com)
- Like D-17, the three cell lines expressed p53 proteins that were capable of activating promoters with p53 response elements on their own, and synergistically with Zhangfei. (biomedcentral.com)
Sequence7
- Sequence analysis suggested that putative CREBH response element (CREBHRE) is located in the human APOA5 promoter region and is highly conserved in both human and rodent. (hindawi.com)
- Additionally, sequence variation at C/EBP site I, which lies immediately upstream of the distal nuclear factor kappa B site and immediately downstream of a binding site for activating transcription factor (ATF)/cyclic AMP response element binding protein (CREB), has been shown to affect HIV-1 long terminal repeat (LTR) activity. (asm.org)
- Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding . (genecards.org)
- Each species' promoter contains a cAMP/response element (CRE) 1 consensus sequence ( [7] ) upstream of a TATA box. (wikiversity.org)
- fnx1 + encodes a protein with sequence similarity to the proton-driven plasma membrane transporters from the multidrug resistance group of the major facilitator superfamily of proteins. (asm.org)
- 1987 ). However, it was later found that, instead of a single polypeptide, many polypeptides can bind to the sequence (Hai et al. (springer.com)
- Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
Membrane2
- Single-pass type II membrane protein. (abcam.com)
- Ecto-5′-nucleotidase (CD73) is a membrane-bound glycoprotein that functions to hydrolyze extracellular nucleotides into bioactive nucleoside intermediates ( 2 ). (jimmunol.org)
Serine1
- For example, CBP and p300 binding to RELA are enhanced when serine 276 or 311 is phosphorylated. (wikipedia.org)
Putative1
- In this study, we observed the existence of a putative "megaplasmid," multiple copies of ribosomal RNA operons, and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. (medworm.com)
Characterization2
- Our understanding of cyclic AMP signaling in the nucleus has expanded considerably over the past decade, owing in large part to the characterization of cyclic AMP-responsive promoter elements, transcription factors that bind them, and signal-dependent coactivators that mediate target gene induction. (nih.gov)
- This chapter makes a journey about CMS2 tumour characterization, their conventional treatment, and how modulation of Wnt signalling or immune response may be applied to CRC therapy. (springer.com)
Regulator1
- Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. (biovendor.com)
Downstream3
- Downstream elements d. (brainscape.com)
- We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70. (jimmunol.org)
- The diagram shows an overview of the four core promoter elements B recognition element (BRE), TATA box , initiator element (Inr), and downstream promoter element (DPE), with their respective consensus sequences and their distance from the transcription start site . (wikiversity.org)
MeSH1
- Cyclic AMP Response Element-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Neurons2
- Here we report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome. (semanticscholar.org)
- Other research demonstrated that the protein CREB can help pinpoint the neurons linked to a particular memory. (dana.org)
CREB15
- Here, we characterize, for the first time, a CREB1-like protein in the central nervous system (CNS) of Lymnaea, a model system used widely for the study of the fundamental mechanisms of learning and memory. (nih.gov)
- We demonstrate cAMP response element (CRE)-binding activity in CNS protein extracts and show that one of the CRE-binding proteins is recognized by a polyclonal antibody raised to mammalian (human) CREB1. (nih.gov)
- Moreover, phospho-CREB1-specific immunoreactivity is increased significantly in protein extracts of the CNS by forskolin, an activator of adenylate cyclase. (nih.gov)
- Significantly, classical food-reward conditioning increases phospho-CREB1 immunoreactivity in Lymnaea CNS protein extracts. (nih.gov)
- In response to drug exposure, CREB1 is phosphorylated in the striatum, a structure that is critically involved in reward-related learning. (isharonline.org)
Mediate1
- The primary function attributed to endothelial CD73 has been catabolism of extracellular nucleotides, although CD73 may also mediate lymphocyte binding under some circumstances ( 8 ). (jimmunol.org)
Nuclear7
- Transcriptional activators include C/EBP α ( 4 ), C/EBP β (nuclear factor interleukin-6), (IL-6) ( 2 , 9 , 12 , 40 ), C/EBP δ ( 42 ), C/EBP ɛ ( 44 ), and C/EBP-related protein 1 (CRP-1) ( 42 ). (asm.org)
- Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y and increased nuclear factor κB transcriptional signalling mediated these effects. (bmj.com)
- The cAMP response element binding protein (CREB) is a ubiquitously expressed nuclear transcription factor that is activated by various extracellular stimuli. (ahajournals.org)
- Nuclear factor-κB and activator protein 1 are relatively well-studied redox-sensitive transcription factors involved in the various aspects of the cardiovascular disease process. (ahajournals.org)
- The cAMP response element (CRE) binding protein (CREB) is a nuclear transcription factor and is ubiquitously expressed. (ahajournals.org)
- Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. (wikipedia.org)
- In vertebrates, the best-characterized nuclear targets of PKA are the cyclic AMP response element-binding (CREB) proteins. (kuleuven.be)
Promoter region1
- We also showed that CREB binds to IGF-IR promoter region and identified the relevant CREB-binding site at the 5â ²-untranslated region fragment of IGF-IR promoter. (unict.it)
Mammalian2
- Lam L, Bresnick E. Identity of the beta-globin locus control region binding protein HS2NF5 as the mammalian homolog of the notch-regulated transcription factor suppressor of hairless. (labome.org)
- The mammalian AP1 proteins are homodimers and heterodimers composed of proteins from the Jun (JUN, JUNB and JUND) and Fos (FOS, FOSB, FRA1 and FRA2) families, and the closely related activating transcription factor (Atf and Creb) subfamily and the Maf subfamily 5 . (pubmedcentralcanada.ca)
CAMP respons3
- The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also pivotal in the switch from short-term to long-term memory. (dovepress.com)
- CREB was detected using gel mobility-shift analysis with the radiolabeled Ca2+/cAMP response element of the c-fos promoter. (aspetjournals.org)
- The cloned CD73 gene promoter bears a cAMP response element (CRE) 3 ( 12 ), which is one of the consensus DNA motifs that regulate transcription through the cAMP-dependent coactivator CRE binding protein (CREB) ( 13 ). (jimmunol.org)
19992
- 1999 ). Because the consensus ATF binding site is the same as the cAMP responsive element (CRE) (Montminy and Bilezsikjian 1987 ) and because ATF1 is 75% similar. (springer.com)
- A paper in the April 1999 Nature Neuroscience coauthored by the assistant professor of neuroscience indicates that a protein called CREB may provide links to the past. (brownalumnimagazine.com)
Role10
- Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established. (semanticscholar.org)
- On the other hand, mitochondria, particularly mitochondrial ROS production, have a crucial role in regulating the gut microbiota via modulating intestinal barrier function and mucosal immune responses. (frontiersin.org)
- More than a decade ago, research had already begun to illuminate the vital role of specific proteins in memory storage. (dana.org)
- It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. (abcam.com)
- This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. (genecards.org)
- Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). (genecards.org)
- Isoform 2 plays a role in the unfolded protein response (UPR). (genecards.org)
- Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). (genecards.org)
- Hannila SS, Filbin MT. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. (biovendor.com)
- Role of cyclic AMP response element binding protein in human leukemias. (biovendor.com)
Modulator1
- The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009) CAMP responsive element modulator has been shown to interact with FHL5. (wikipedia.org)
Induction2
- In each SREBP-regulated promoter, at least one ubiquitous co-regulatory factor that binds to a neighboring recognition site is also required for efficient gene induction. (elsevier.com)
- Subsequent studies revealed that similar exposure conditions increase surface protein through transcriptional induction of CD73. (jimmunol.org)
UniProt1
- p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)