A pyridine nucleotide that mobilizes CALCIUM. It is synthesized from nicotinamide adenine dinucleotide (NAD) by ADP RIBOSE CYCLASE.
An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.
A pentose active in biological systems usually in its D-form.
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
A specific subtype of muscarinic receptor that has a high affinity for the drug PIRENZEPINE. It is found in the peripheral GANGLIA where it signals a variety of physiological functions such as GASTRIC ACID secretion and BRONCHOCONSTRICTION. This subtype of muscarinic receptor is also found in neuronal tissues including the CEREBRAL CORTEX and HIPPOCAMPUS where it mediates the process of MEMORY and LEARNING.
An inorganic dye used in microscopy for differential staining and as a diagnostic reagent. In research this compound is used to study changes in cytoplasmic concentrations of calcium. Ruthenium red inhibits calcium transport through membrane channels.
The largest and uppermost of the paravertebral sympathetic ganglia.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A cell line derived from cultured tumor cells.
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
A class of carbohydrates that contains five carbon atoms.
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Somewhat flattened, globular echinoderms, having thin, brittle shells of calcareous plates. They are useful models for studying FERTILIZATION and EMBRYO DEVELOPMENT.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Diseases of plants.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
A part of the embryo in a seed plant. The number of cotyledons is an important feature in classifying plants. In seeds without an endosperm, they store food which is used in germination. In some plants, they emerge above the soil surface and become the first photosynthetic leaves. (From Concise Dictionary of Biology, 1990)
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.

CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose. (1/314)

CD38 is a type II transmembrane glycoprotein that is expressed by many cell types including lymphocytes. Signaling through CD38 on B lymphocytes can mediate B cell activation, proliferation, and cytokine secretion. Additionally, coligation of CD38 and the B cell Ag receptor can greatly augment B cell Ag receptor responses. Interestingly, the extracellular domain of CD38 catalyzes the conversion of NAD+ into nicotinamide, ADP-ribose (ADPR), and cyclic ADPR (cADPR). cADPR can induce intracellular calcium release in an inositol trisphosphate-independent manner and has been hypothesized to regulate CD38-mediated signaling. We demonstrate that replacement of the cytoplasmic tail and the transmembrane domains of CD38 did not impair CD38 signaling, coreceptor activity, or enzyme activity. In contrast, independent point mutations in the extracellular domain of CD38 dramatically impaired signal transduction. However, no correlation could be found between CD38-mediated signaling and the capacity of CD38 to catalyze an enzyme reaction and produce cADPR, ADPR, and/or nicotinamide. Instead, we propose that CD38 signaling and coreceptor activity in vitro are regulated by conformational changes induced in the extracellular domain upon ligand/substrate binding, rather than on actual turnover or generation of products.  (+info)

Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. (2/314)

Ca2+ released from presynaptic and postsynaptic intracellular stores plays important roles in activity-dependent synaptic plasticity, including long-term depression (LTD) of synaptic strength. At Schaffer collateral-CA1 synapses in the hippocampus, presynaptic ryanodine receptor-gated stores appear to mobilize some of the Ca2+ necessary to induce LTD. Cyclic ADP-ribose (cADPR) has recently been proposed as an endogenous activator of ryanodine receptors in sea urchin eggs and several mammalian cell types. Here, we provide evidence that cADPR-mediated signaling pathways play a key role in inducing LTD. We show that biochemical production of cGMP increases cADPR concentration in hippocampal slices in vitro, and that blockade of cGMP-dependent protein kinase, cADPR receptors, or ryanodine-sensitive Ca2+ stores each prevent the induction of LTD at Schaffer collateral-CA1 synapses. A lack of effect of postsynaptic infusion of either cADPR antagonist indicates a probable presynaptic site of action.  (+info)

An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells. (3/314)

Oscillations of Ca2+ in heart cells are a major underlying cause of important cardiac arrhythmias, and it is known that Ca2+-induced release of Ca2+ from intracellular stores (the sarcoplasmic reticulum) is fundamental to the generation of such oscillations. There is now evidence that cADP-ribose may be an endogenous regulator of the Ca2+ release channel of the sarcoplasmic reticulum (the ryanodine receptor), raising the possibility that cADP-ribose may influence arrhythmogenic mechanisms in the heart. 8-Amino-cADP-ribose, an antagonist of cADP-ribose, suppressed oscillatory activity associated with overloading of intracellular Ca2+ stores in cardiac myocytes exposed to high doses of the beta-adrenoreceptor agonist isoproterenol or the Na+/K+-ATPase inhibitor ouabain. The oscillations suppressed by 8-amino-cADP-ribose included intracellular Ca2+ waves, spontaneous action potentials, after-depolarizations, and transient inward currents. Another antagonist of cADP-ribose, 8-bromo-cADP-ribose, was also effective in suppressing isoproterenol-induced oscillatory activity. Furthermore, in the presence of ouabain under conditions in which there was no arrhythmogenesis, exogenous cADP-ribose was found to be capable of triggering spontaneous contractile and electrical activity. Because enzymatic machinery for regulating the cytosolic cADP-ribose concentration is present within the cell, we propose that 8-amino-cADP-ribose and 8-bromo-cADP-ribose suppress cytosolic Ca2+ oscillations by antagonism of endogenous cADP-ribose, which sensitizes the Ca2+ release channels of the sarcoplasmic reticulum to Ca2+.  (+info)

The role of ryanodine receptors in the cyclic ADP ribose modulation of the M-like current in rodent m1 muscarinic receptor-transformed NG108-15 cells. (4/314)

1. The role of cyclic ADP ribose and ryanodine receptors in the inhibition of the M-like current (IK(M,ng)) by acetylcholine was investigated in m1 muscarinic receptor-transformed mouse neuroblastoma-rat glioma hybrid (NG108-15) cells using patch-clamp techniques and calcium microfluorimetry. 2. Acetylcholine (1-100 microM) decreased IK(M,ng) by up to 55 %. Application, via the patch pipette, of the cyclic ADP ribose antagonists 8-amino-cyclic ADP ribose (10-100 microM) and 8-bromo-cyclic ADP ribose (100-1000 microM) reduced this inhibition of IK(M,ng) in a concentration-dependent manner. The half-maximal inhibition concentrations for 8-amino- cyclic ADP ribose and 8-bromo-cyclic ADP ribose were around 40 microM and 1 mM, respectively. 3. Neither of the cyclic ADP ribose antagonists altered the amplitude of IK(M,ng) per se, or the incidence of the concurrent Ca2+-activated K+ current (IIK(Ca)) activation, also mediated by acetylcholine. 4. The ryanodine receptor modulators ryanodine (1-10 microM) and Ruthenium Red (10 microM) did not alter IK(M,ng) amplitude or IK(M,ng) inhibition mediated by acetylcholine. There was a statistically significant increase in the proportion of cells showing outward currents in the presence of Ruthenium Red. 5. Intracellular calcium levels measured with fura-2 microfluorimetry were increased with low concentrations of ryanodine (1 microM), more consistently with caffeine (10 mM), and in almost every case with both bradykinin (300 nM) and acetylcholine (100 microM). Caffeine-, but not bradykinin-evoked responses were abolished by preincubation with ryanodine (10 microM). 6. The fast 'rundown rate' of the M-current recorded in rat superior cervical ganglion cells under whole-cell conditions precluded an investigation of the effects of intracellular dialysis of cyclic ADP ribose. However, when cyclic ADP ribose (5 microM) was applied directly to the cytoplasmic face of inside-out membrane patches excised from rat superior cervical ganglion cells containing M-channels, it had no effect on the main parameters of single channel activity (conductance, mean open time or frequency of opening). 7. These results indicate that cyclic ADP ribose acts on a specific intracellular site to mediate IK(M,ng) inhibition. However, unlike previously established effects of cyclic ADP ribose, the ryanodine receptor is not required, suggesting that another molecular target may be involved. Studies at the single channel level indicate that cyclic ADP ribose may not act directly on the M-channels in inside-out patches.  (+info)

Hydrolysis of NADP+ by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2'-phosphate. (5/314)

CD38 is a multifunctional cell surface ectoenzyme that catalyzes both the synthesis of cyclic ADP-ribose from NAD+ and its hydrolysis to ADP-ribose. In this work, we investigated the metabolism of NADP+ by CD38 expressed on human platelets. Incubation of either platelet membranes or intact cells with NADP+ resulted in the rapid and time-dependent accumulation of ADP-ribose 2'-phosphate that paralleled the consumption of the substrate. However, under the same conditions, synthesis of cyclic ADP-ribose 2'-phosphate was not observed. By immunoprecipitation experiments, we identified CD38 as the enzyme responsible for the observed NADP+ glycohydrolase activity. The lack of detection of cyclic ADP-ribose 2'-phosphate was not due to its rapid hydrolysis, since direct incubation of platelet membranes with cyclic ADP-ribose 2'-phosphate did not result in the formation of ADP-ribose 2'-phosphate. By contrast, the same membrane samples expressed a significant ability to hydrolyze cyclic ADP-ribose to ADP-ribose. The absence of cyclic ADP-ribose 2'-phosphate hydrolase activity was also confirmed using high concentrations of substrate and by analysing both intact Jurkat T-lymphocytes and immunoprecipitated CD38. These results indicate that CD38, which is a multifunctional enzyme towards NAD+, displays exclusively a NADP+ glycohydrolase activity and is unable to catalyze both the synthesis and the hydrolysis of cyclic ADP-ribose 2'-phosphate.  (+info)

Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle. (6/314)

Actions of photoreleased cADP-ribose (cADPR), a novel regulator of calcium-induced calcium release (CICR) from ryanodine-sensitive stores, were investigated in cardiac myocytes. Photoreleased cADPR caused an increase in the magnitude of whole-cell calcium transients studied in mammalian cardiac ventricular myocytes (both guinea-pig and rat) using confocal microscopy). Approx. 15 s was required following photorelease of cADPR for the development of its maximal effect. Photoreleased cADPR also increased the frequency of calcium 'sparks', which are thought to be elementary events which make up the whole-cell calcium transient, and were studied in rat myocytes, but had little or no effect on spark characteristics (amplitude, rise time, decay time and distance to half amplitude). The potentiating effects of photoreleased cADPR on both whole-cell transients and the frequency of calcium sparks were prevented by cytosolic application of the antagonist 8-amino-cADPR (5 microM). These experiments, therefore, provide the first evidence in any cell type for an effect of cADPR on calcium sparks, and are the first to show the actions of photoreleased cADPR on whole-cell calcium transients in mammalian cells. The observations are consistent with the effects of cADPR in enhancing the calcium sensitivity of CICR from the sarcoplasmic reticulum in cardiac ventricular myocytes, leading to an increase in the probability of occurrence of calcium sparks and to an increase in whole-cell calcium transients. The slow time-course for development of the full effect on whole-cell calcium transients might be taken to indicate that the influence of cADPR on CICR may involve complex molecular interactions rather than a simple direct action of cADPR on the ryanodine-receptor channels.  (+info)

CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. (7/314)

The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD(+) to cyclic ADP-ribose (cADPr). The latter gates Ca(2+) release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library. The predicted amino acid sequence displayed 59, 59, and 50% similarity, respectively, to the mouse, rat, and human CD38. In situ RT-PCR revealed intense cytoplasmic staining of osteoclasts, confirming CD38 mRNA expression. Both confocal microscopy and Western blotting confirmed the plasma membrane localization of the CD38 protein. The ADP-ribosyl cyclase activity of osteoclastic CD38 was next demonstrated by its ability to cyclize the NAD(+) surrogate, NGD(+), to its fluorescent derivative cGDP-ribose. We then examined the effects of CD38 on osteoclast function. CD38 activation by an agonist antibody (A10) in the presence of substrate (NAD(+)) triggered a cytosolic Ca(2+) signal. Both ryanodine receptor modulators, ryanodine, and caffeine, markedly attenuated this cytosolic Ca(2+) change. Furthermore, the anti-CD38 agonist antibody expectedly inhibited bone resorption in the pit assay and elevated interleukin-6 (IL-6) secretion. IL-6, in turn, enhanced CD38 mRNA expression. Taken together, the results provide compelling evidence for a new role for CD38/ADP-ribosyl cyclase in the control of bone resorption, most likely exerted via cADPr.  (+info)

Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores. (8/314)

Long-term depression (LTD) of synaptic transmission can be induced by several mechanisms, one thought to involve Ca2+-dependent activation of postsynaptic nitric oxide (NO) synthase and subsequent diffusion of NO to the presynaptic terminal. We used the stable NO donor S-nitroso-N-acetylpenicillamine (SNAP) to study the NO-dependent form of LTD at Schaffer collateral-CA1 synapses in vitro. SNAP (100 microM) enhanced the induction of LTD via a cascade that was blocked by the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoic acid (50 microM), NO guanylyl cyclase inhibitor 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (10 microM), and the PKG inhibitor KT5823 (1 microM). We further show that LTD induced by low-frequency stimulation in the absence of SNAP also is blocked by KT5823 or Rp-8-(4-chlorophenylthio)-guanosine 3',5'-cyclic monophosphorothioate (10 microM), cyclic guanosine 3',5' monophosphate-dependent protein kinase (PKG) inhibitors with different mechanisms of action. Furthermore SNAP-facilitated LTD was blocked when release from intracellular calcium stores was inhibited by ryanodine (10 microM). Finally, two cell-permeant antagonists of the cyclic ADP-ribose binding site on ryanodine receptors also were able to block the induction of LTD. These results support a cascade for induction of homosynaptic, NO-dependent LTD involving activation of guanylyl cyclase, production of guanosine 3',5' cyclic monophosphate and subsequent PKG activation. This process has an additional requirement for release of Ca2+ from ryanodine-sensitive stores, perhaps dependent on the second-messenger cyclic ADP ribose.  (+info)

Nicotinic acid-adenine dinucleotide phosphate (NAADP) is a newly described Ca2+-mobilizing nucleotide that appears to target intracellular Ca2+-release channels distinct from those sensitive to inositol trisphosphate or ryanodine/cyclic ADP-ribose. Little, however, is known concerning the regulation of cellular NAADP levels. In the present study, we have characterized the metabolism of NAADP by brain membranes. From HPLC and MS analyses we show that loss of NAADP was associated with the appearance of a major product that is likely to be nicotinic acid-adenine dinucleotide (NAAD), the dephosphorylated form of NAADP. Dephosphorylation of NAADP, but not 3-NAADP, was dramatically attenuated by Ca2+ chelators and stimulated by Ca2+ over a physiological range in a calmodulin-insensitive manner. In contrast, NADP was metabolized predominantly to ADP-ribose phosphate via glycohydrolase activity, although slower Ca2+-dependent dephosphorylation of both NADP and 2-AMP could also be demonstrated. This is the
Cyclic adenosine diphosphate ribose (cADPR) is a potent endogenous calcium-mobilizing agent synthesized from beta-NAD+ by ADP-ribosyl cyclases in sea urchin eggs and in several mammalian cells (Galione, A., and White, A. (1994) Trends Cell Biol. 4, 431 436). Pharmacological studies suggest that cADPR is an endogenous modulator of Ca2+-induced Ca2+ release mediated by ryanodine-sensitive Ca2+ release channels. An unresolved question is whether cADPR can act as a Ca2+-mobilizing intracellular messenger. We show that exogenous application of nitric oxide (NO) mobilizes Ca2+ from intracellular stores in intact sea urchin eggs and that it releases Ca2+ and elevates cADPR levels in egg homogenates. 8-Amino-cADPR, a selective competitive antagonist of cADPR-mediated Ca2+ release, and nicotinamide, an inhibitor of ADP-ribosyl cyclase, inhibit the Ca2+-mobilizing actions of NO, while, heparin, a competitive antagonist of the inositol 1,4,5-trisphosphate receptor, did not affect NO-induced Ca2+ release. Since the
In addition to its well established function in activating Ca(2+) release from the endoplasmic reticulum (ER) through ryanodine receptors (RyR), the second messenger cyclic ADP-ribose (cADPR) also accelerates the activity of SERCA pumps, which sequester Ca(2+) into the ER. Here, we demonstrate a potential physiological role for cADPR in modulating cellular Ca(2+) signals via changes in ER Ca(2+) store content, by imaging Ca(2+) liberation through inositol trisphosphate receptors (IP(3)R) in Xenopus oocytes, which lack RyR. Oocytes were injected with the non-metabolizable analog 3-deaza-cADPR, and cytosolic [Ca(2+)] was transiently elevated by applying voltage-clamp pulses to induce Ca(2+) influx through expressed plasmalemmal nicotinic channels. We observed a subsequent potentiation of global Ca(2+) signals evoked by strong photorelease of IP(3), and increased numbers of local Ca(2+) puffs evoked by weaker photorelease. These effects were not evident with cADPR alone or following cytosolic Ca(2+)
BACKGROUND AND PURPOSE: Recently, a number of mimics of the second messenger cyclic ADP-ribose (cADPR) with replacement of adenosine by inosine were introduced. In addition, various alterations in the molecule ranging from substitutions at C8 of the base up to full replacement of the ribose moieties still retained biological activity. However, nothing is known about the metabolic stability and cellular effects of these novel analogues. EXPERIMENTAL APPROACH: cADPR and the inosine-based analogues were incubated with CD38, ADP-ribosyl cyclase and NAD-glycohydrolase and metabolism was analysed by RP-HPLC. Furthermore, the effect of the analogues on cytokine expression and proliferation was investigated in primary T-lymphocytes and T-lymphoma cells. KEY RESULTS: Incubation of cADPR with CD38 resulted in degradation to adenosine diphosphoribose. ADP-ribosyl cyclase weakly catabolised cADPR whereas NAD-glycohydrolase showed no such activity. In contrast, N1-cyclic inosine 5-diphosphoribose (N1-cIDPR) was not
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) mobilize Ca2+ from two different types of intracellular stores and through completely independent mechanisms. The two Ca2+ messengers are also structurally distinct. cADPR is a cyclic nucleotide derived from NAD, whi …
Clone REA465 recognizes the human CD157 antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as bone marrow stromal antigen 1 (BST-1) or cyclic ADP-ribose hydrolase 2. CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule, which synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, former a second messenger that elicits calcium release from intracellular stores. It is mainly expressed by cells of the myeloid lineage, bone marrow stroma, and vascular endothelium. CD157 is also expressed by ovarian cancer epithelium and by peritoneal mesothelial cells, where it is implicated in tumor dissemination. Further, it is endowed with receptor-like features observed in different cell types and transduces signals by interacting with transmembrane partner molecules, a strategy shared by other GPI-anchored molecules. CD157 is involved in neutrophil polarization, adhesion, and motility and controls
Title: Role of CD38 in Airway Function. VOLUME: 2 ISSUE: 2. Author(s):Bit Na Kang, Alonso G.P. Guedes, K. G. Tirumurugaan, Joseph A. Jude, Deepak A. Deshpande, Reynold A. Panettieri, Yassine Amrani, Frances E. Lund, Timothy F. Walseth and Mathur S. Kannan. Affiliation:Department of Veterinary andBiomedical Sciences, College of Veterinary Medicine, University ofMinnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA.. Keywords:Cyclic ADP-ribose, airway smooth muscle, calcium, cytokines, asthma. Abstract: CD38, a 45-kDa cell surface glycoprotein, is involved in the synthesis of the calcium mobilizing second messenger molecule cyclic ADP-ribose. Cyclic ADP-ribose is known to release calcium from the sarcoplasmic reticulum of airway smooth muscle cells. The pharmacological features of cyclic ADP-ribose-mediated calcium release in airway smooth muscle cells are distinct from those mediated by inositol 1,4,5-trisphosphate and involve activation of ryanodine receptor channels. In airway smooth ...
The human lymphocyte antigen CD38 has been shown to share sequence homology with ADP-ribosyl cyclase, the enzyme that catalyzes the conversion of NAD+ to cyclic ADP-ribose (cADPR), a potent Ca(2+)-mobilizing agent. In this study COS1 cells from African Green Monkey kidney were transiently transfected with CD38 cDNA, inducing expression of authentic CD38 on the cell surface. We demonstrate that CD38 expressed in this manner can convert NAD+ to cADPR in the extracellular medium as assessed by Ca2+ release from sea-urchin egg microsomes.
CD38 is a 42-kilodalton glycoprotein expressed extensively on B and T lymphocytes. CD38 exhibits a structural homology to Aplysia adenosine diphosphate (ADP)-ribosyl cyclase. This enzyme catalyzes the synthesis of cyclic ADP-ribose (cADPR), a metabolite of nicotinamide adenine dinucleotide (NAD +) with calcium-mobilizing activity. A complementary DNA encoding the extracellular domain of murine CD38 was constructed and expressed, and the resultant recombinant soluble CD38 was purified to homogeneity. Soluble CD38 catalyzed the formation and hydrolysis of cADPR when added to NAD+. Purified cADPR augmented the proliferative response of activated murine B cells, potentially implicating the enzymatic activity of CD38 in lymphocyte function ...
Although activation of M2 muscarinic receptors is classically known to inhibit adenylyl cyclase activity (Peralta et al., 1988) or to modify membrane potential by inhibiting Ca2+-activated K+ channel (Kotlikoff et al., 1992), it has been recently proposed that M2 muscarinic receptors may induce Ca2+ signals by activation of the cADPR pathway (White et al., 2003) or by stimulation of a voltage-dependent Ca2+ channel (Cav1.2b) via the phosphatidylinositol 3-kinase/PKC pathway (Callaghan et al., 2004). Activation of the cADPR pathway by ACh in duodenum myocytes is shown by: (1) inhibition of Ca2+ oscillations by application of the cADPR competitive antagonist (8Br-cADPR), (2) inhibition of ACh-induced Ca2+ oscillations by inhibitors of ADP-ribosyl cyclase (ZnCl2, anti-CD38 antibody) and (3) detection of ADP-ribosyl cyclase activity by fluorescence experiments as the enzyme cyclizes NGD+ (non fluorescent) to produce cGDPR, a fluorescent compound (Graeff et al., 1994). This method has been used ...
Ligation of the T-cell receptor/CD3 complex results in global Ca(2+) signals that are essential for T-cell activation. We have recently reported that these global Ca(2+) signals are preceded by localized pacemaker Ca(2+) signals. Here, we demonstrate for the first time for human T cells that an increase in signal frequency of subcellular pacemaker Ca(2+) signals at sites close to the plasma membrane, in the cytosol and in the nucleus depends on the type 3 ryanodine receptor (RyR) and its modulation by cyclic ADP-ribose. The spatial distribution of D-myo-inositol 1,4,5-trisphosphate receptors and RyRs indicates a concerted action of both of these receptors/Ca(2+) channels in the generation of initial pacemaker signals localized close to the plasma membrane. Inhibition or knockdown of RyRs resulted in significant decreases in (1) the frequency of initial pacemaker signals localized close to the plasma membrane, and (2) the frequency of localized pacemaker Ca(2+) signals in the inner cytosol. Moreover,
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell. 2005 Apr 1;18(1):61-9. PMED ID: 15808509. ...
NAADP (nicotinic acid-adenine dinucleotide phosphate), the most potent Ca2+-mobilizing second messenger, is active in a wide range of organisms and cell types. Until now, all NAADP-producing enzymes have been thought to be members of the ADP-ribosyl cyclase family. ADP-ribosyl cyclases exhibit promiscuous substrate selectivity, synthesize a variety of products and are regulated in a limited manner, which may be non-physiological. In the present paper, we report the presence of an enzyme on the surface of sea urchin sperm that exhibits bell-shaped regulation by Ca2+ over a range (EC(50) of 10 nM and IC(50) of 50 microM) that is physiologically relevant. Uniquely, this surface enzyme possesses complete selectivity for nucleotides with a 2-phosphate group and exhibits only base-exchange activity without any detectable cyclase activity. Taken together, these findings indicate that this novel enzyme should be considered as the first true NAADP synthase.
Multiple mechanisms exist for increasing the concentration of intracellular calcium. This Perspective by Lee is one in a series on intracellular calcium release mechanisms and focuses on the calcium store operated by nicotinic acid adenine dinucleotide phosphate (NAADP). The characterization of the NAADP-operated calcium store as separate from the inositol trisphosphate (IP3)-operated and cyclic ADP-ribose (cADPR)-operated calcium stores is discussed. Lee also addresses the role of NAADP in regulating intracellular calcium fluctuations during fertilization and hormonal activation of pancreatic acinar cells.. ...
Nicotinamide adenine dinucleotide (NAD+) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD+ and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD+ and NAD+ phosphate metabolites adenosine 5′-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca2+ signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD+ signaling (www.NAD2008.de).. ...
Cadp-ribose/ACM119340535 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS ...
This multiunctional enzyme catalyses both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2-phospho-ADP-ribosyl cyclase/2-phospho-cyclic-ADP-ribose transferase. cf. EC 3.2.2.5, NAD+ glycohydrolase ...
یک تیم از دانشمندان به رهبری دانشگاه ناگویا در ژاپن شناسایی کرده بسیار غیر معمول اتمی پیکربندی در یک تنگستن-بر اساس مواد. تا به حال اتمی پیکربندی کرده و دیده می شود در trihydrogen یک یون وجود دارد که در بین سیستم های ستاره ای در فضا است. یافته های منتشر شده در مجله Nature Communicationsنشان می دهد مطالعات بیشتر می تواند آشکار ترکیبات با جالب خواص الکترونیکی.. اتم را تشکیل می دهند که انسان ها و درختان و جداول آشپزخانه به طور کلی پیوند با یکدیگر با به اشتراک گذاشتن الکترون - فکر می کنم از الکترون ها از اتمی به عنوان چسب زندگی است. دانشگاه ناگویا اعمال فیزیکدان Yoshihiko Okamoto و ...
Kurose Hitomi , Okamoto Mayumi , Shimizu Miyuki , BITO Takaaki , MARCELLE Cristophe , NOJI Sumihare , OHUCHI Hideyo Development, growth & differentiation 47(4), 213-223, 2005-06-01 参考文献35件 被引用文献2件 ...
Viavi Solutions Koji Okamoto discusses how the company is adapting its testing products to meet the challenges of Remote PHY and Fiber Deep.
Okamoto, M., Iguchi, T., Hattori, T., Matsuzaki, S., Koyama, Y., Taniguchi, M., Komada, M., Xie, M. J., Yagi, H., Shimizu, S., Konishi, Y., Omi, M., Yoshimi, T., Tachibana, T., Fujieda, S., Katayama, T., Ito, A., Hirotsune, S., Tohyama, M. & Sato, M., 18-02-2015, In: Journal of Neuroscience. 35, 7, p. 2942-2958 17 p.. 研究成果: Article › 査読 ...
Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be elevated by -NAD+, cADPR, and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the incubation temperature is increased, the [Ca2+]i in hypothalamic neurons is elevated. However, it has not been determined whether OT release is facilitated by heat in vitro or hyperthermia in vivo in combination with cADPR. Furthermore, it has not been examined whether CD38 and TRPM2 exert their functions on OT release during stress or stress-induced hyperthermia in relation to the anxiolytic roles and social behaviors of OT under stress conditions. Here, we report that OT release from the isolated hypothalami of male mice in culture was enhanced by extracellular application of cADPR or increasing the
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success. Significantly, conversion of NADP into the important mammalian second
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The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, ...
A Membrane-bound or cytosolic enzyme that catalyzes the synthesis of Cyclic ADP-Ribose (cADPR) from Nicotinamide Adenine Dinucleotide (NAD). This enzyme generally catalyzes the Hydrolysis of cADPR to ADP-Ribose, as well, and sometimes the synthesis of Cyclic ADP-Ribose 2 phosphate (2-P-cADPR) from NADP ...
As the result of successful collaboration with Dr. K. Mikoshibas laboratory in RIKEN Brain Science Institute, Tokyo, Japan, we found that pancreatic protease activation by alcohol metabolite mainly depends on Ca2+ release via acid store IP3 receptors (Gerasimenko J. et al, PNAS, 2009). Currently there is no specific pharmacological treatment for pancreatitis. However, now our research has identified the critical proteins responsible for the excessive calcium release which is where the problem begins with the possibility to search for specific chemical compounds for the treatment of acute pancreatitis.. I am investigating the action of nicotinic acid adenine dinucleotide phosphate (NAADP), a novel Ca2+ releasing messenger and its role in the induction of pathological processes of exocrine pancreas. Our findings (Gerasimenko J, et al., JCS, 2006) show that the NAADP-sensitive Ca2+ pool is located in the endoplasmic reticulum and in acidic organelles, which are represented by secretory granules, ...
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.
Increasing evidence has indicated that NAD+ and NADH play critical roles not only in energy metabolism, but also in cell death and various cellular functions including regulation of calcium homeostasis and gene expression. It has also been indicated that NAD+ and NADH are mediators of multiple major biological processes including aging. NAD+ and NADH produce the biological effects by regulating numerous NAD+/NADH-dependent enzymes, including dehydrogenases, poly(ADP-ribose) polymerases, Sir2 family proteins (sirtuins), mono(ADP-ribosyl)transferases, and ADP-ribosyl cyclases. Of particular interest, NAD+-dependent generation of ADP-ribose, cyclic ADP-ribose and O-acetyl-ADP-ribose can mediate calcium homeostasis by affecting TRPM2 receptors and ryanodine receptors; and sirtuins and PARPs appear to play key roles in aging, cell death and a variety of cellular functions. It has also been indicated that NADH and NAD+ can be transported across plasma membranes of cells, and that extracellular NAD+ ...
Social Mobilizer Jobs in Pakistan for the month of September 2021. You can find Social Mobilizer Jobs online at JobStock in Pakistan.
Zhumadilov, Kassym; Ivannikov, Alexander; Stepanenko, Valeriy; Zharlyganova, Dinara; Zhumadilov, Zhaxybay; Apsalikov, Kazbek; Toyoda, Shin; Zhumadilova, Anara; Endo, Satoru; Tanaka, Kenichi; Miyazawa, Chuzou; Yamamoto, Masayoshi; Okamoto, Tetsuji; Hoshi, Masaharu; ...
Okamoto, Jun*; Mamiya, Kazutoshi*; Fujimori, Shinichi; Okane, Tetsuo; Saito, Yuji; Muramatsu, Yasuji*; Yoshii, Kenji; Fujimori, Atsushi*; Tanaka, Arata*; Abbate, M.*; et al.. Physical Review B, 71(10), p.104401_1 - 104401_5, 2005/03. ...
Tao Okamoto is a gown wearing diva for the December issue of Numéro China. Photographed by John-Paul Pietrus and styled by Tim Lim, the Japanese model is full of attitude ...
Nicotinic acid adenine dinucleotide phosphate (NAADP) has recently been shown to act as a second messenger controlling intracellular Ca responses in mammalian cells. Many questions remain regarding this signaling pathway, including the role of the ryanodine receptor (RyR) in NAADP-induced Ca transients. Furthermore, the exact metabolic pathway responsible for the synthesis of NAADP in vivo has not been determined. Here, we demonstrate that the NAADP mediated Ca release system is present in human myometrial cells. We also demonstrate that human myometrial cells use the NAADP second messenger system to generate intracellular Ca transients in response to histamine. It has been proposed in the past that the NAADP system in mammalian cells is dependent on the presence of functional RyRs. Here, we observed that the histamine-induced Ca transients are dependent on both the NAADP and inositol 1,4,5-trisphosphate signaling pathways but are independent of RyRs. The enzyme CD38 has been shown to catalyze ...
Mutations in LRRK2 (leucine-rich repeat kinase 2) represent a significant component of both sporadic and familial PD (Parkinsons disease). Pathogenic mutations cluster in the enzymatic domains of LRRK2, and kinase activity seems to correlate with cytotoxicity, suggesting the possibility of kinase-based therapeutic strategies for LRRK2-associated PD. Apart from cytotoxicity, changes in autophagy have consistently been observed upon overexpression of mutant, or knockdown of endogenous, LRRK2. However, delineating the precise mechanism(s) by which LRRK2 regulates autophagy has been difficult. Recent data suggest a mechanism involving late steps in autophagic-lysosomal clearance in a manner dependent on NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive lysosomal Ca2+ channels. In the present paper, we review our current knowledge of the link between LRRK2 and autophagic-lysosomal clearance, including regulation of Ca2+-dependent events involving NAADP.
Tsuchiya, T and Okamoto, K, The relationship between the oxygen consumption of various tissues and the radiosensitivity in mice. I. Oxygen consumption of various tissues in the normal physiological state of mice. (jap.) (1965). Subject Strain Bibliography 1965. 974 ...
The IUPHAR/BPS Guide to Pharmacology. ADP ribose ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Kondo-Ando, M., Seino, Y., Morikawa, R., Negi, K., Todoroki, H., Kawakami, T., Asada, Y., Yoshimoto, R., Tanaka, C., Okamoto, K., Masuda, A., Tomatsu, E., Hiratsuka, I., Yoshino, Y., Maki, W., Kakita, A., Shibata, M., Takayanagi, T., Makino, M., Sugimura, Y. および7人, Asai, S., Ito, A., Ueno, S., Fujiwara, Y., Kuwata, H., Yabe, D. & Suzuki, A., 11-2019, : : Journal of Diabetes and its Complications. 33, 11, 107415.. 研究成果: Article ...
Affiliation:福井大学,学術研究院医学系部門(附属病院部),講師, Research Field:Otorhinolaryngology, Keywords:鼻科学,浸潤,ケモカイン,DEPs,スギ花粉症,内分泌撹乱物質,STAT6,血管新生,IgE,酸化ストレス, # of Research Projects:4, # of Research Products:6, Ongoing Project:遺伝子導入による顔面神経軸索再生の試み
Freitas, H. S., Okamoto, M. M., David Silva, A., Sabino-Silva, R., Furuya, D. T., Souza, M. O. de, & Machado, U. F. (2010). O envolvimento da AKT na regulação da transcrição gênica de GLUT2 e SGLT2 em rim de diabéticos, via insulina e o fator transcricional HNF-3β. In Resumos. São Paulo: FeSBE ...
Freitas, H. S., Okamoto, M. M., David Silva, A., Sabino-Silva, R., Furuya, D. T., Souza, M. O. de, & Machado, U. F. (2010). O envolvimento da AKT na regulação da transcrição gênica de GLUT2 e SGLT2 em rim de diabéticos, via insulina e o fator transcricional HNF-3β. In Resumos. São Paulo: FeSBE ...
Its our favourite excuse to stay in on a Saturday night, but one we might not be able to use this year - ITV are said to be considering postponing the...
Ca 2+ signaling in spermatozoa plays a crucial role during processes such as capacitation and release of the acrosome, but the underlying molecular mechanisms still remain unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca 2+ -releasing second messenger in a variety of cellular processes. The presence of a NAADP synthesizing enzyme in sea urchin sperm has been previously reported, suggesting a possible role of NAADP in sperm Ca 2+ signaling. In this work we used in vitro enzyme assays to show the presence of a novel NAADP synthesizing enzyme in human sperm, and to characterize its sensitivity to Ca 2+ and pH. Ca 2+ fluorescence imaging studies demonstrated that the permeable form of NAADP (NAADP-AM) induces intracellular [Ca 2+ ] increases in human sperm even in the absence of extracellular Ca 2+ . Using LysoTracker®, a fluorescent probe that selectively accumulates in acidic compartments, we identified two such stores in human sperm cells. Their acidic nature was further
A Membrane-bound or cytosolic enzyme that catalyzes the synthesis of Cyclic ADP-Ribose (cADPR) from Nicotinamide Adenine Dinucleotide (NAD). This enzyme generally catalyzes the Hydrolysis of cADPR to ADP-Ribose, as well, and sometimes the synthesis of Cyclic ADP-Ribose 2 phosphate (2-P-cADPR) from NADP ...
Antony Giuseppe Galione (born 1963) FRS FMedSci is professor of Pharmacology and Wellcome Trust Senior Investigator in the Department of Pharmacology at the University of Oxford. Galione was educated at Felsted School in Essex and Trinity College, Cambridge where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985 followed by a PhD in 1989 for research on calcium signalling in the blowfly salivary gland supervised by Michael Berridge. Galiones research investigates calcium signalling. He established the concept of multiple calcium mobilising messengers which link cell surface stimuli to release of internal calcium stores, and identified their target two-pore channels (TPCs) and organelles. This has enhanced our understanding of how calcium as a ubiquitous cellular regulator may control a myriad of cellular processes with precision. He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals, and that ...
A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging in intact sea-urchin eggs.
Game Republic (Folklore) founder Yoshiki Okamoto is a game development legend, having created titles such as Time Pilot, 1942, and Street Fighter II -
TY - JOUR. T1 - Potential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. AU - Guedes, Alonso Gp. AU - Rude, Elaine P.. AU - Kannan, Mathur S.. PY - 2013/9. Y1 - 2013/9. N2 - Objective: To investigate the CD38/cADPR signaling pathway as possible underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. Animals: Thirty-two C57BL/6 mice of both sexes. Methods: Wild-type (WT) and CD38-knockout (CD38-/-) mice received medetomidine (50 μg kg-1) or a similar volume of 0.9% NaCl (control) by intraperitoneal (IP) injection (each group n = 8). The mice were euthanized 45 minutes later with sodium pentobarbital IP and blood was sampled via cardiac puncture. Insulin and glucose concentrations were measured by radioimmunoassay and by the oxygen rate method, respectively. Data were analyzed with anova and Bonferroni post hoc (5% significance) and are shown as mean ± SD. Results: Plasma ...
Affiliation:島根大学,医学部,准教授, Research Field:Pathological medical chemistry,Hematology,Cardiovascular medicine,Emergency medicine,Urology, Keywords:血管内皮細胞,トロンボモジュリン,炎症,ギャップ結合,コネキシン,プロテインCインヒビター,プロテインC,活性化プロテインC,プロテインS,血液凝固, # of Research Projects:14, # of Research Products:122, Ongoing Project:腹部臓器大網乳班が分泌するトレロソームが敗血症による免疫麻痺を引き起こす
東京大学大学院新領域創成科学研究科 国際交流室の公式サイト。国際交流室の紹介、入試情報など。
Celebrity is a fickle thing. Some who have it prefer to hide - the Kevin Spaceys, Dave Chapelles and Doris Days of the world - while others seem to relish the spotlight - the Kanye Wests, Joseph…
Keiko Okamoto, Norihito Emura, Hajime Sato, Yuki Fukatsu, Mitsuru Saito, Chie Tanaka, Yukako Morita, Kayo Nishimura, Eriko Kuramoto, Dong Xu Yin, Kazuharu Furutani, Makoto Okazawa, Yoshihisa Kurachi, Takeshi Kaneko, Yoshinobu Maeda, Takashi Yamashiro, Kenji Takada, Hiroki Toyoda and Youngnam Kang ...
The Robert and Donna Heider Engineering Scholarship is available to full - time undergraduate students enrolled in the University of Missouri-St. Louis/Washington University joint engineering progr...
... is a multifunctional enzyme that catalyzes the synthesis of ADP ribose (ADPR) (97%) and cyclic ADP-ribose (cADPR) (3%) ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15". Cytogenetics and Cell Genetics. 69 (1-2): 38-9. doi: ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ...
Like its mechanistic cousins, IP3 and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca2+ ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ... In contrast to IP3 and cyclic ADP-ribose which predominantly mobilize Ca2+ from the neutral and abundant endoplasmic reticulum ... Cyclic ADP-ribose IP3 Clapper, David L.; Walseth, Timothy F.; Dargie, Peter J.; Lee, Hon Cheung (1987). "Pyridine Nucleotide ...
... as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP- ... Poly(ADP-ribosyl)ation is carried out by the poly(ADP-ribose) polymerases. The poly(ADP-ribose) structure is involved in the ... Another function of this coenzyme in cell signaling is as a precursor of cyclic ADP-ribose, which is produced from NAD+ by ADP- ... ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP-ribosylation, or the transferral of ...
SARM1 catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. SARM1 activation locally ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ...
"Release of Ca2+ from individual plant vacuoles by both InsP3 and cyclic ADP-ribose". Science. 268 (5211): 735-737. Bibcode: ...
... that catalyze the formation of nicotinamide and adenosine diphosphate ribose (ADPR) or cyclic ADP-ribose (cADPR) from NAD+. ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ...
Galione established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals, and ... modulation by cyclic ADP-ribose". Science. 253 (5024): 1143-1146. doi:10.1126/science.1909457. PMID 1909457. S2CID 43565315. ...
Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, Yonekura H, Okamoto H (February 1997). "Cyclic ADP-ribose binds to ...
Physiological agonist: Cyclic ADP-ribose can act as a physiological gating agent. It has been suggested that it may act by ... In heart and pancreas cells, another second messenger (cyclic ADP-ribose) takes part in the receptor activation. The localized ...
Cyclic ADP-Ribose and NAADP: Structure, Metabolism and Functions. Kluwer Academic Publishers, 2002. ISBN 1-40207-281-3. ... La poli-ADP-ribosilació té lloc gràcies a l'acció de les poli(ADP-ribosa) polimerases.[53][50] L'estructura poli(ADP-ribosa) ... 53,0 53,1 Burkle A «Poly(ADP-ribose). The most elaborate metabolite of NAD+». FEBS J., 272, 18, 2005, pàg. 4576-89. DOI: ... 50,0 50,1 Diefenbach J, Bürkle A «Introduction to poly(ADP-ribose) metabolism». Cell. Mol. Life Sci., 62, 7-8, 2005, pàg. 721- ...
An example of this reaction can be seen in the cyclization cyclic ADP ribose, which is an important molecule for intracellular ... Since sugars are present in the structure of nucleic acids, with a ribose sugar present in RNA and a deoxyribose present in the ...
NAD+ is converted into cyclic ADP ribose (cADPR), a second messenger which interacts with ryanodine receptors (RyR) on the ... "Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in ...
Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2) at the PDBe-KB. Ortolan E, Vacca P, Capobianco A, et al. (2003). " ... or cyclic ADP-ribose (cADPR) from NAD+, although CD157 is a much weaker catalyst than CD38. cADPR is required for regulation of ... Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene ... CD157 and CD38 are both members of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of nicotinamide and ...
... as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP- ... ADP-ribosyl)ation is carried out by the poly(ADP-ribose) polymerases.[54][57] The poly(ADP-ribose) structure is involved in the ... Another function of this coenzyme in cell signaling is as a precursor of cyclic ADP-ribose, which is produced from NAD+ by ADP- ... is also consumed in ADP-ribose transfer reactions. For example, enzymes called ADP-ribosyltransferases add the ADP-ribose ...
Lee HC (2002). Cyclic ADP-Ribose and NAADP: Structure, Metabolism and Functions. Kluwer Academic Publishers. ISBN 1-4020-7281-3 ...
... o-acetyl-adp-ribose MeSH D09.408.620.569.070.125.195 - cyclic adp-ribose MeSH D09.408.620.569.070.125.600 - poly adenosine ... ribose MeSH D09.546.627.867 - xylose MeSH D09.546.627.885 - xylulose MeSH D09.546.894.200 - dihydroxyacetone MeSH D09.546. ... diphosphate ribose MeSH D09.408.620.569.200 - cytidine diphosphate diglycerides MeSH D09.408.620.569.400 - guanosine ... adenosine diphosphate ribose MeSH D09.408.620.569.070.125.040 - ...
... is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR ... Lee HC (2011). "Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling". Science China Life Sciences. 54 ... Adenosine diphosphate ADP-ribosylation Ribose Braidy N, Berg J, Clement J, Sachdev P (2019). "Role of Nicotinamide Adenine ... September 2004). "TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) ...
... is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP- ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15". Cytogenetics and Cell Genetics. 69 (1-2): 38-9. doi: ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ...
... as many TIR domain-containing proteins from bacteria and archaea can degrade NAD+ into the products nicotinamide and ADP-ribose ... ADPR) (or cyclic-ADPR). Ig-like domain is the part of receptor which is located extracellulary. There are minimal homologies in ...
... and cyclic-ADP ribose. ADP-ribose is a protein-glycating agent, and excess levels of ADP-ribose in the cell can cause non- ... Other common names for ADP-ribose diphosphatase include ADP-ribose pyrophosphatase and ADPRase. ADP-ribose is commonly referred ... ADP-ribose diphosphatase, in particular, hydrolyzes ADP-ribose into AMP and D-ribose 5-phosphate, both of which are ... "Human placenta hydrolases active on free ADP-ribose: an ADP-sugar pyrophosphatase and a specific ADP-ribose pyrophosphatase". ...
Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ... "Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase". ... Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups ... NAADP IP3 ADP-ribose Lee HC, Walseth TF, Bratt GT, Hayes RN, Clapper DL (1989). "Structural determination of a cyclic ...
... o-acetyl-adp-ribose MeSH D13.695.827.708.070.125.195 - cyclic adp-ribose MeSH D13.695.827.708.070.125.600 - poly adenosine ... o-acetyl-adp-ribose MeSH D13.695.667.138.124.070.125.195 - cyclic adp-ribose MeSH D13.695.667.138.180 - adenosine monophosphate ... o-acetyl-adp-ribose MeSH D13.695.827.068.124.070.125.195 - cyclic adp-ribose MeSH D13.695.827.068.180 - adenosine monophosphate ... cyclic cmp MeSH D13.695.462.275 - cyclic gmp MeSH D13.695.462.275.325 - dibutyryl cyclic gmp MeSH D13.695.462.300 - cyclic imp ...
During the late 1980s, ADP-ribosyl cyclases, which catalyze the addition of cyclic-ADP-ribose groups to proteins, were ... ADP-ribose) glycohydrolase, an enzyme that hydrolyses poly(ADP-ribose) to produce free ADP-ribose. Studies have shown poly-ADP- ... mono-ADP ribosylation and poly-ADP ribosylation. Mono-ADP ribosyltransferases commonly catalyze the addition of ADP-ribose to ... Poly-(ADP-ribose) polymerases (PARPs) are found mostly in eukaryotes and catalyze the transfer of multiple ADP-ribose molecules ...
ADP-ribose/poly(ADP-ribose)-binding or ADP-ribose 1''-phosphate phosphatase activities and cyclic nucleotide phosphodiesterase ...
Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine ... The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of four nucleoside ...
Burkle A (2005). "Poly(ADP-ribose). The most elaborate metabolite of NAD+". FEBS J. 272 (18): 4576-89. PMID 16156780. doi: ... Guse AH (2004). "Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)". Curr. Med. Chem. 11 (7 ... A ADP-ribosilación implica quer a adición dun só grupo ADP-ribosa (mono-ADP-ribosilación) quer a transferencia de ADP-ribosa ás ... ADP-ribosil)ación lévana a cabo as poli(ADP-ribosa) polimerases.[53][56] A estrutura da poli-(ADP-ribosa) está implicada na ...
ADP-ribose) glycohydrolase EC 3.2.1.144: 3-deoxyoctulosonase EC 3.2.1.145: galactan 1,3-b-galactosidase EC 3.2.1.146: b- ... cyclic-GMP phosphodiesterase EC 3.1.4.36: now with EC 3.1.4.43 EC 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase EC 3.1 ... Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase EC 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase EC 3.6.1.55: 8-oxo- ... ADP-ribose diphosphatase EC 3.6.1.14: adenosine-tetraphosphatase EC 3.6.1.15: nucleoside-triphosphatase EC 3.6.1.16: CDP- ...
Like most sugars, ribose exists as a mixture of cyclic forms in equilibrium with its linear form, and these readily ... Metabolically-important species that include phosphorylated ribose include ADP, ATP, coenzyme A, and NADH. cAMP and cGMP serve ... Ribokinase catalyzes the conversion of d-ribose to d-ribose 5-phosphate. Once converted, d-ribose-5-phosphate is available for ... Supplemental d-ribose can bypass part of the pentose phosphate pathway, an energy-producing pathway, to produce d-ribose-5- ...
Song D, Sakamoto S, Taniguchi T (2002). "Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ... Goodin JL, Rutherford CL (2003). "Characterization of human ribosomal S3a gene expression during adenosine 3':5' cyclic ...
AMP does not have the high energy phosphoanhydride bond associated with ADP and ATP. AMP can be produced from ADP: 2 ADP → ATP ... AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes ... AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine; it is an ester of phosphoric acid and the ... Though the γ-subunit can bind AMP/ADP/ATP, only the binding of AMP/ADP results in a conformational shift of the enzyme protein ...
response to organic cyclic compound. • regulation of double-strand break repair via homologous recombination. • DNA metabolic ... Poly ADP ribose polymerase. *Nucleotide excision repair/ERCC *XPA. *XPB. *XPC. *XPD/ERCC2 ...
ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners". J. Biol. Chem. 278 (41): 39265-8. doi:10.1074/jbc. ... response to organic cyclic compound. • negative regulation of cyclin-dependent protein serine/threonine kinase activity. • ...
... contains a thymine base joined to a ribose pentose sugar. ...
PARP14 encoding protein Poly(ADP-ribose) polymerase family member 14. *PCCB: propionyl Coenzyme A carboxylase, beta polypeptide ... ARPP-21: Cyclic AMP-regulated phosphoprotein, 21 kDa. *AZI2: encoding protein 5-azacytidine-induced protein 2 ...
... is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. ... Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine ...
1⁄2 NADH + cyt cox + ADP + Pi ⇌ ​1⁄2 NAD+ + cyt cred + ATP. which directly implies this equation:. [. c. y. t. c. r. e. d. ]. [ ... In terms of its structure, ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar (ribose ... cyclic AMP, which is involved in triggering calcium signals by the release of calcium from intracellular stores.[24] This form ... ATP hydrolyses to ADP and phosphate. Living cells maintain the ratio of ATP to ADP at a point ten orders of magnitude from ...
Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ... inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice". ...
Essayan DM (2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555 ...
ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ... a sugar backbone attached to adenine and two phosphate groups bonded to the 5 carbon atom of ribose. The diphosphate group of ... Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is ... that ADP is used (GTP + ADP → GDP + ATP).[9] ... ADP in the blood is converted to adenosine by the action of ...
It is a cyclic ether and a monoterpenoid.. Eucalyptol is also known by a variety of synonyms: 1,8-cineol, 1,8-cineole, ... ADP-ribose. *BCTC. *Calcium (intracellular). *Cold. *Coolact P. *Cooling Agent 10. *CPS-369 ...
Ribose. ADP-ribosyltransferase. *NAD+:diphthamide ADP-ribosyltransferase *Diphtheria toxin. *Pseudomonas exotoxin. *NAD(P)+: ... First discovered in Gram-negative bacteria, both Cyclic AMP (cAMP) and cAMP Receptor Protein (CRP) function in sucrose ... Conversely, ADP would likely stimulate sucrose phosphorylase to increase levels of ATP. Further research on the subject would ... Through a series of reactions, glucose-6-phosphate can be converted into ribose-5-phosphate, which is used for a variety of ...
The Syntheses of Sulphones, Sulphoxides and Cyclic Sulphides. Chichester UK: John Wiley & Sons. pp. 112-6. ISBN 978-0-471-93970 ... ADP-ribose. *BCTC. *Calcium (intracellular). *Cold. *Coolact P. *Cooling Agent 10. *CPS-369 ...
Ribose. ADP-ribosyltransferase. *NAD+:diphthamide ADP-ribosyltransferase *Diphtheria toxin. *NAD(P)+:arginine ADP- ... cyclic AMP (cAMP) to more than 100-fold over normal and over-activates cytosolic PKA. These active PKA then phosphorylate the ... The CTA1 fragment catalyses ADP-ribosylation of the Gs alpha subunit (Gαs) proteins using NAD. The ADP-ribosylation causes the ... The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) ...
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... Cleavage of the ribose and N-methylation yields 7-methylxanthosine. 7-Methylxanthosine in turn is the precursor to theobromine ... Theobromine is weaker in both its inhibition of cyclic nucleotide phosphodiesterases and its antagonism of adenosine receptors. ...
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ...
Category:EC 3.5.2 (In cyclic amides) *Beta-lactamase (EC 3.5.2.6) ... EC 6.2.1.5: Succinate--CoA ligase (ADP-forming). *EC 6.2.1.6: ... D-ribose pyranase EC 5.5.1.22 Steroid Delta Isomerase Category:EC 5.99 (other isomerases)Edit. *Category:EC 5.99.1 * ... Category:EC 3.5.4 (In cyclic amidines) *Adenosine deaminase (EC 3.5.4.4) ...
ADP + a phosphoprotein. Thus, the two substrates of this enzyme are ATP and a protein, whereas its two products are ADP and ... which was a general EC number for any enzyme that phosphorylates proteins while converting ATP to ADP (i.e., ATP:protein ... 3',5'-cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
... cyclic AMP receptor - cyclic AMP receptor protein - cyclic AMP-responsive DNA-binding protein - cyclic electron flow - Cyclic ... ribose - ribosomal protein - ribosomal protein S6 kinase - ribosome - RNA - RNA virus - RNA-binding protein - RNA-directed DNA ... ADP) - adenosine monophosphate (AMP) - adenosine triphosphate (ATP) - adenovirus - adrenergic receptor - adrenodoxin - aequorin ... nucleotide - cyclic peptide - cyclin - cyclin A - cyclin B - cyclin E - cyclin-dependent kinase - cycloleucine - cyclosporin - ...
DNA is defined by containing 2'-deoxy-ribose nucleic acid while RNA is defined by containing ribose nucleic acid. In some ... Ribonucleotides can be converted to cyclic adenosine monophosphate (cyclic AMP) to regulate hormones in organisms as well. In ... dATP and dGTP are synthesized from ADP and GDP, respectively. They are first reduced by RNR and then phosphorylated by ... The pathway begins with the conversion of Ribose-5-Phosphate(R5P) to phosphoribosyl pyrophosphate (PRPP) by enzyme ribose- ...
Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced ... This shows cyclic variations in oxygenation implying dynamic regulation of the metabolic symbiosis between lactate-producing ... Ribose-5-phosphate acts as an intermediate for the production of nucleotides thus providing a connection between glycolysis and ... Pyruvate kinase is shown to convert phosphoenolpyruvate to pyruvate forming ATP from ADP. Along with phospho-fructokinase 1, ...
Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ... "Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase". ... Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups ... NAADP IP3 ADP-ribose Lee HC, Walseth TF, Bratt GT, Hayes RN, Clapper DL (1989). "Structural determination of a cyclic ...
Buy Cyclic ADP-Ribose and NAADP by Hon Cheung Lee from Waterstones today! Click and Collect from your local Waterstones or get ... Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions (Paperback). Hon Cheung Lee (author) Sign in to write a ... we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose ... regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of ...
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca(2+) messengers derived from NAD ... Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.. Lee HC1. ... Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP- ...
Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and ... Keywords: Adenine Dinucleotide Phosphate; Cyclic ADP-ribose; D-myo-inositol 1,4,5-trisphosphate; Guanosine triphosphate; ... cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). This review concentrates on (i) receptor- ... mediated formation of cADPR by ADP-ribosyl cyclases, (ii) intracellular and extracellular effects of cADPR in a variety of cell ...
Calcium signaling: Nuclear Reaction Makes Cyclic ADP Ribose Message Subject. (Your Name) has forwarded a page to you from ... Ryanodine receptors, which function as calcium channels activated by binding of cyclic ADP ribose (cADPr), are present in ... now report that ADP-ribose cyclase or CD38, the membrane-associated enzyme that generates cADPr from nicotinamide adenine ... A new function for CD38/ADP-ribosyl cyclase in nuclear calcium homeostasis. Nature Cell Biol. 1: 409-414. [Online Journal] ...
cADPR is a cyclic nucleotide derived from NAD, whi … ... Cyclic ADP-ribose (cADPR) and nicotinic acid adenine ... A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP Biol Chem. Jul-Aug 1999;380(7 ... Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) mobilize Ca2+ from two different types of ... cADPR is a cyclic nucleotide derived from NAD, while NAADP is a linear metabolite of NADP. Systems responsive to these two ...
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second ...
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. Details. Name. ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. Synonyms. ... Cyclic ADP-ribose hydrolase 2. Gene Name. BST1. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0002471,ADP-ribosyl cyclase/ ... lcl,BSEQ0010864,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1) ... Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger ...
Cyclic ADP-Ribose and NAADP: A Story of Two Calcium Messengers; H.C. Lee. ADP-Ribosyl Cyclases: A Family of cADPR and NAADP ... Cyclic ADP-Ribose and Vasomotor Response; P.L. Li, et al. Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic ... Pharmacology of Cyclic ADP-Ribose and NAADP Synthesis and Properties of Analogs; T.F. Walseth, H.C. Lee. Separate but ... The CD38-Cyclic ADP-Ribose Signal System in Pancreatic beta-Cells. The Discovery and Biological Significance of a Novel Signal ...
... we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose ... regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of ... ADP_Ribose_and_NAADP.html?hl=es&id=UfUpyJZW0roC&utm_source=gb-gplus-shareCyclic ADP-Ribose and NAADP. ... Cyclic ADP-Ribose and NAADP: Structures, Metabolism, and Functions. editado por Hon Cheung Lee ...
... or ADP-ribose-evoked TRPM2 activity is robustly potentiated at elevated temperatures. We also show that, even though cyclic ADP ... TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion EMBO J. 2006 May 3;25(9):1804-15. ... ribose (cADPR) does not activate TRPM2 at 25 degrees C, co-application of heat and intracellular cADPR dramatically potentiates ...
In CICR in the heart, both cyclic ADP-ribose (cADP-ribose) and Ca2+ cooperatively activate type-II ryanodine receptors to ... Hashii, M., Minabe, Y. and Higashida, H., 2000, Cyclic ADP-ribose potentiates Ca2+ elevation and Ca2+ entry via L-type voltage- ... Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Asai, K. and Kato, T., 2001, Cyclic ADP-ribose as a potential second ... 2002) Sympathetic Potentiation of Cyclic ADP-Ribose Formation in Rat Cardiac Myocytes. In: Nagatsu T., Nabeshima T., McCarty R ...
... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ...
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15. Cytogenetics and Cell Genetics. 69. 38-39 (1995). *. ... Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) ... Publications] S.Takasawa: Cyclic ADP-ribose in β cells. Science. 262. 585-585 (1993). *. Related Report. 1993 Annual Research ... Publications] S.TAKASAWA: Cyclic ADP-ribose in insulin secretion from pancreatic β cells. Science. 259. 370-373 (1993). *. ...
... cyclic adenosine diphosphate-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP+). In HIV-1-infected ... primary human astrocytes and measured CD38 expression using real-time polymerase chain reaction and CD38 function by ADP- ... CD38/Cyclic ADP-Ribose Regulates Astrocyte Calcium Signaling: Implications for Neuroinflammation and HIV-1-Associated Dementia ... article{Banerjee2008CD38CyclicAR, title={CD38/Cyclic ADP-Ribose Regulates Astrocyte Calcium Signaling: Implications for ...
However, unlike most other members, SpARC4 shows a remarkable preference for producing cyclic ADP-ribose over nicotinic acid ... the ADP-ribosyl cyclases. Not all ADP-ribosyl cyclases have been identified, and how production of different messengers is ... Here, we report the cloning and characterization of a novel ADP-ribosyl cyclase (SpARC4) from the sea urchin, a key model ... Like several other members of the ADP-ribosyl cyclase superfamily, SpARC4 is a glycoprotein targeted to the plasma membrane via ...
These approaches allow the synthesis of analogs with stable linkages between N1 of adenine and the northern ribose (or ... Hydrolysis resistant analogs were generated by replacing the southern ribose with a carbocyclic structure or by replacing the ... hydroxyl group of the southern ribose for activity. ... Cyclic ADP-ribose (cADPR) is a signaling molecule that has been ... analogs was synthesized by a chemo-enzymatic approach that took advantage of the broad substrate specificity of Aplysia ADP- ...
Title: Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling ... Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and ... Andreas H. Guse, " Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca ... Keywords: Cyclic ADP-ribose, Nicotinic Acid, Adenine Dinucleotide Phosphate, Novel Regulators, Nuclear Localization, Guanosine ...
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ADP-ribose 1"-2" cyclic phosphate is a strong basic compound (based on its pKa). ADP-ribose 1"-2" cyclic phosphate exists in ... ADP-ribose 1"-2" cyclic phosphate , also known as ADP ribose 1,2-phosphate, belongs to the class of organic compounds known ... ADP-Ribose 1"-2" cyclic phosphoric acid. *{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(5R)-2 ... ADP-ribose 1"-2" cyclic phosphate." Science 261:206-208.8392224 *Shull, N. P., Spinelli, S. L., Phizicky, E. M. (2005). "A ...
... Academic Article ... This enzyme catalyzes the synthesis of cyclic ADP-ribose (cADPR), a metabolite of nicotinamide adenine dinucleotide (NAD +) ... CD38 exhibits a structural homology to Aplysia adenosine diphosphate (ADP)-ribosyl cyclase. ...
Such membrane impermeance of other charged intracellular messengers (including cyclic AMP, inositol 1,4,5-trisphosphate and ... Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative ... Synthesis and use of cell-permeant cyclic ADP-ribose. Rosen D., Bloor-Young D., Squires J., Parkesh R., Waters G., Vasudevan SR ... Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative ...
... the enzyme that catalyzes the conversion of NAD+ to cyclic ADP-ribose (cADPR), a potent Ca(2+)-mobilizing agent. In this study ... The human lymphocyte antigen CD38 has been shown to share sequence homology with ADP-ribosyl cyclase, ... ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1, Adenosine Diphosphate Ribose, Animals, Antigens, CD, Antigens, Differentiation, ... the enzyme that catalyzes the conversion of NAD+ to cyclic ADP-ribose (cADPR), a potent Ca(2+)-mobilizing agent. In this study ...
Cyclic ADP-ribose (cADPr) is a potent Ca2+-mobilizing natural compound (Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N ... Adenosine Diphosphate Ribose, Calcium, Cyclic ADP-Ribose, Fluorescent Dyes, Fura-2, Humans, Jurkat Cells, Microinjections, ... Cyclic ADP-ribose (cADPr) is a potent Ca2+-mobilizing natural compound (Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N ...
... Mol Cell. 2005 Apr 1;18( ... Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels 4/1/2005 ...
cyclic ADP ribose;. PMCA,. plasma membrane Ca2+ pump;. SERCA,. ER/SR Ca2+ pump;. NCX,. Na+/Ca2+ exchanger;. LTP,. long-term ... and cyclic ADP ribose (cADPr). cADPr is assumed to act on channels that are also called ryanodine receptors and that are ... The process was an alternative to ADP phosphorylation in the usage of respiratory energy. Provided that the amount accumulated ... the metabolism of cyclic nucleotides, and the activity of type A K+ channels. Most NCSs are N-terminally myristoylated. After ...
Cyclic ADP ribose; PARPs: Poly ADP-ribose polymerases. ...
Nitric oxide signalling often operates in mammalian cells through cyclic GMP (cGMP)- and cyclic ADP ribose (cADPR)-dependent ... cyclic ADP ribose; cGMP, cyclic GMP; GPX, glutathione peroxidase; GSNO, S-nitroso-L-glutathione; GST, glutathione S-transferase ... Cyclic ADP ribose has been implicated as another second messenger for NO signalling in animals, acting in a cGMP-dependent ... and cyclic ADP-ribose. Proc Natl Acad Sci USA 95: 10328-10333.. *CrossRef , ...
keywords = "3-deaza-cyclic ADP-ribose, Calcium release, Cyclic ADP-ribose, cADPR", ... a potent and stable analog of cyclic ADP-ribose. Together they form a unique fingerprint. * Cyclic ADP-Ribose Chemical ... Cyclic 3-deaza-adenosine diphosphoribose: a potent and stable analog of cyclic ADP-ribose. Biochimica et Biophysica Acta - ... Cyclic 3-deaza-adenosine diphosphoribose : a potent and stable analog of cyclic ADP-ribose. / Wong, Long; Aarhus, Robert; ...
... it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of spe ... Cyclic ADP-ribose, NAD hydrolysis and ADP-ribose synthesis. * Front Matter Pages 227-227 ... ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in ... protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the ...
  • Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N1) of the same adenine base (whose position N9 has the glycosidic bond to the other ribose). (wikipedia.org)
  • The N1-glycosidic bond to adenine is what distinguishes cADPR from ADP-ribose (ADPR), the non-cyclic analog. (wikipedia.org)
  • cADPR is produced from nicotinamide adenine dinucleotide (NAD+) by ADP-ribosyl cyclases (EC 3.2.2.5) as part of a second messenger system. (wikipedia.org)
  • cADPR and ADPR are synthesized from NAD+ by the bifunctional ectoenzymes of the CD38 family (also includes the GPI-anchored CD157 and the specific, monofunctional ADP ribosyl cyclase of the mollusc Aplysia). (wikipedia.org)
  • In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. (waterstones.com)
  • The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. (waterstones.com)
  • Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca(2+) messengers derived from NAD and NADP, respectively. (nih.gov)
  • Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. (nih.gov)
  • Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide. (ingentaconnect.com)
  • Release from intracellular Ca 2+ stores is accomplished by the small molecular compounds D-myo-inositol 1,4,5-trisphosphate (InsP 3 ), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). (ingentaconnect.com)
  • This review concentrates on (i) receptor-mediated formation of cADPR by ADP-ribosyl cyclases, (ii) intracellular and extracellular effects of cADPR in a variety of cell types, and (iii) cADPR in the nucleus. (ingentaconnect.com)
  • Ryanodine receptors, which function as calcium channels activated by binding of cyclic ADP ribose (cADPr), are present in nuclear membranes with their ligand binding sites facing the nucleoplasm. (sciencemag.org)
  • now report that ADP-ribose cyclase or CD38, the membrane-associated enzyme that generates cADPr from nicotinamide adenine dinucleotide (NAD+), is present in the inner nuclear membrane, with its catalytic region on the nucloplasmic side. (sciencemag.org)
  • Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) mobilize Ca2+ from two different types of intracellular stores and through completely independent mechanisms. (nih.gov)
  • cADPR is a cyclic nucleotide derived from NAD, while NAADP is a linear metabolite of NADP. (nih.gov)
  • Despite their functional and structural differences, cADPR and NAADP are sibling messengers synthesized by a single enzyme, ADP-ribosyl cyclase. (nih.gov)
  • We also show that, even though cyclic ADP-ribose (cADPR) does not activate TRPM2 at 25 degrees C, co-application of heat and intracellular cADPR dramatically potentiates TRPM2 activity. (nih.gov)
  • Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. (frontiersin.org)
  • Previously, we showed that the intracellular free calcium concentration ([Ca 2+ ] i ) that seems to trigger OT release can be elevated by β-NAD + , cADPR, and ADP in mouse oxytocinergic neurons. (frontiersin.org)
  • CD38 is a 45-kD ectoenzyme involved in the synthesis of potent calcium (Ca2+)-mobilizing agents, cyclic adenosine diphosphate-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP+). (semanticscholar.org)
  • Cyclic ADP-ribose (cADPR) is a signaling molecule that has been shown to regulate calcium mobilization from intracellular stores in a wide variety of biological systems. (ox.ac.uk)
  • The first generation of cADPR analogs was synthesized by a chemo-enzymatic approach that took advantage of the broad substrate specificity of Aplysia ADP-ribosyl cyclase. (ox.ac.uk)
  • This enzyme catalyzes the synthesis of cyclic ADP-ribose (cADPR), a metabolite of nicotinamide adenine dinucleotide (NAD +) with calcium-mobilizing activity. (uab.edu)
  • Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). (ox.ac.uk)
  • The human lymphocyte antigen CD38 has been shown to share sequence homology with ADP-ribosyl cyclase, the enzyme that catalyzes the conversion of NAD+ to cyclic ADP-ribose (cADPR), a potent Ca(2+)-mobilizing agent. (ox.ac.uk)
  • Cyclic 3-deaza-adenosine diphosphoribose (3-deaza-cADPR), an analog of cyclic adenosine diphosphoribose (cADPR) was synthesized. (unthsc.edu)
  • In 1992 the enzymatic activity of CD38 was discovered, having the capacity to synthesize the calcium-releasing second messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). (wikipedia.org)
  • CD38 is a multifunctional enzyme that catalyzes the synthesis of ADP ribose (ADPR) (97%) and cyclic ADP-ribose (cADPR) (3%) from NAD+. (wikipedia.org)
  • Like CD38, CD157 is a member of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of cADPR from NAD+, although CD157 is a much weaker catalyst than CD38. (wikipedia.org)
  • Native human HL-60 cells do not express CD38, a multifunctional ectoenzyme, which generates cyclic ADP-ribose (cADPR), a potent calcium mobilizer. (unige.it)
  • Because cyclic ADP-ribose (cADPR) regulates ryanodine receptors and is synthesized from beta-NAD(+), we investigated the regulation by beta-NADH of cADPR synthesis and metabolism and the role of cADPR in hypoxic pulmonary vasoconstriction. (ox.ac.uk)
  • Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. (genome.jp)
  • Concomitantly, a family of ectocellular enzymes, the ADP-ribosyl cyclases (ARCs), has emerged as being able to change their enzymatic mode from one of nucleotide cyclization in formation of cADPR to a base-exchange reaction in the generation of NAADP. (biologists.org)
  • CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. (thermofisher.com)
  • CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD + to ADP-ribose in addition to synthesis of NAADP from NADP+. (wikipedia.org)
  • A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate. (semanticscholar.org)
  • Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate are ubiquitous calcium-mobilizing messengers produced by the same family of multifunctional enzymes, the ADP-ribosyl cyclases. (semanticscholar.org)
  • Such membrane impermeance of other charged intracellular messengers (including cyclic AMP, inositol 1,4,5-trisphosphate and nicotinic acid adenine dinucleotide phosphate) and fluorescent dyes (including fura-2 and fluorescein) has been overcome by synthesizing masked analogs (prodrugs), which are passively permeant and hydrolyzed to the parent compound inside cells. (ox.ac.uk)
  • CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. (wikipedia.org)
  • Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. (ox.ac.uk)
  • Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). (novusbio.com)
  • CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a transmembrane glycoprotein found on the surface of some immune cells including plasma cells, activated or immature T and B cells, monocytes, and natural killer cells. (creative-biogene.com)
  • Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. (nih.gov)
  • Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. (nii.ac.jp)
  • These approaches allow the synthesis of analogs with stable linkages between N1 of adenine and the northern ribose (or surrogate) that are not possible with the enzymatic strategy. (ox.ac.uk)
  • Synthesis and use of cell-permeant cyclic ADP-ribose. (ox.ac.uk)
  • In CICR in the heart, both cyclic ADP-ribose (cADP-ribose) and Ca 2+ cooperatively activate type-II ryanodine receptors to release Ca 2+ . (springer.com)
  • Hypoxia stimulates Ca2+ release from intracellular stores in astrocytes via cyclic ADP ribose-mediated activation of ryanodine receptors. (ox.ac.uk)
  • Hypoxic activation of ryanodine receptors requires formation of cyclic ADP ribose, since hypoxic Ca(2+) mobilization was fully prevented by nicotinamide (which inhibits ADP ribosyl cyclase) or by 8-Br-cADP ribose, an antagonist of cyclic ADP ribose. (ox.ac.uk)
  • Our results demonstrate for the first time the involvement of cyclic ADP ribose in hypoxic modulation of Ca(2+) signalling in the central nervous system, and suggest that this modulator of ryanodine receptors may play a key role in the function of astrocytes under conditions of fluctuating O(2) levels. (ox.ac.uk)
  • As duodenum myocytes expressed the three subtypes of ryanodine receptors, an antisense strategy revealed that the ryanodine receptor subtype 2 alone was required to initiate the Ca 2+ oscillations induced by acetylcholine and also by cyclic adenosine diphosphoribose and rapamycin (a compound that induced uncoupling between 12/12.6 kDa FK506-binding proteins and ryanodine receptors). (biologists.org)
  • A unified mechanism of catalysis is also proposed, which takes into consideration the crystallographic structure of ADP-ribosyl cyclase and accounts for its novel multi-functionality. (nih.gov)
  • Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K: Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (drugbank.ca)
  • CD38 exhibits a structural homology to Aplysia adenosine diphosphate (ADP)-ribosyl cyclase. (uab.edu)
  • Ecto-form NADase activity induced by retinoic acid(RA)in HL-60 cells is due to CD38, which has an amino acid sequence homologous to Aplysia ADP-ribosyl cyclase. (nii.ac.jp)
  • CD38, an ADP ribosyl cyclase, is a 45 kDa type II transmembrane protein having a short N-terminal cytoplasmic domain and a long C-terminal extracellular domain, expressed on the surface of various cells including macrophages, lymphocytes, and pancreatic β cells. (springer.com)
  • Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. (springer.com)
  • ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite. (springer.com)
  • 5. Itoh M, Ishihara K, Tomizawa H, Tanaka H, Kobune Y, Ishikawa J, Kaisho T and Hirano T. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. (sciencegateway.org)
  • Belongs to the ADP-ribosyl cyclase family. (abcam.com)
  • Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. (nature.com)
  • Stimulation of ADP-ribosyl cyclase activity by acetylcholine was evaluated in permeabilized cells by measuring the production of cyclic guanosine diphosphoribose (a fluorescent compound), which resulted from the cyclization of nicotinamide guanine dinucleotide. (biologists.org)
  • Not all ADP-ribosyl cyclases have been identified, and how production of different messengers is achieved is incompletely understood. (semanticscholar.org)
  • The ADP-ribosyl cyclases--the current evolutionary state of the ARCs. (semanticscholar.org)
  • Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites. (humpath.com)
  • Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP-ribose. (ox.ac.uk)
  • Role of cyclic ADP-ribose in signal transduction in airway cells. (nii.ac.jp)
  • In addition, some roles of newly identified calcium mobilizing second messenger cyclic ADP-ribose was studied in these cells. (nii.ac.jp)
  • Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. (rcsb.org)
  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. (drugbank.ca)
  • ADP-ribose 1"-2" cyclic phosphate , also known as ADP ribose 1'',2''-phosphate, belongs to the class of organic compounds known as purine nucleotide sugars. (ymdb.ca)
  • ADP-ribose 1"-2" cyclic phosphate is a strong basic compound (based on its pKa). (ymdb.ca)
  • ADP-ribose 1"-2" cyclic phosphate exists in all eukaryotes, ranging from yeast to humans. (ymdb.ca)
  • Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. (genecards.org)
  • this pathway results in production of a mature tRNA in which the phosphodiester bond linking the 5′‐ and 3′‐half molecules is derived from the 2′-3′ cyclic phosphate generated by the splicing endonuclease. (els.net)
  • 1993) An NAD derivative produced during transfer RNA splicing: ADP‐ribose 1″‐2″ cyclic phosphate. (els.net)
  • However, no information on the concentration of cADP-ribose after β-adrenoceptor stimulation has yet been reported (Figure 2). (springer.com)
  • Publications] S.Takasawa,K.Nata et al: 'Cyclic ADP-ribose in insulin secretion from pancreatic beta-cells. (nii.ac.jp)
  • Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. (abcam.com)
  • Furthermore, we show that the calcium and chemotactic responses of leukocytes are not dependent on poly-ADP-ribose polymerase 1 (PARP-1), another potential source of ADPR in some leukocytes. (jimmunol.org)
  • The nucleosides each contain a ribose ring, one with adenine attached to the first carbon atom (the 1' position) and the other with nicotinamide at this position. (wikipedia.org)
  • The CD38-Cyclic ADP-Ribose Signal System in Pancreatic beta-Cells. (wisepress.com)
  • Medicinal chemistry and pharmacology of cyclic ADP-ribose. (ox.ac.uk)
  • Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W. The pharmacology of CD38/NADase: an emerging target in cancer and diseases of aging. (nature.com)
  • Inhibition of cyclic adenosine diphosphoribose-induced Ca 2+ oscillations, after rapamycin treatment, confirmed that both compounds interacted with the ryanodine receptor subtype 2. (biologists.org)
  • Our findings show for the first time that the M2 muscarinic receptor activation triggered Ca 2+ oscillations in duodenum myocytes by activation of the cyclic adenosine diphosphoribose/FK506-binding protein/ryanodine receptor subtype 2 signalling pathway. (biologists.org)
  • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. (genecards.org)
  • beta-NAD(+)- or ADP-ribose-evoked TRPM2 activity is robustly potentiated at elevated temperatures. (nih.gov)
  • Analogs synthesized by this approach provided useful structure-activity information, including the importance of the 8-position of the adenine in determining agonistic or antagonistic activity and of the 3'-hydroxyl group of the southern ribose for activity. (ox.ac.uk)
  • Hydrolysis resistant analogs were generated by replacing the southern ribose with a carbocyclic structure or by replacing the adenine ring with 7-deaza- or 3-deaza-adenine. (ox.ac.uk)
  • a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction. (ox.ac.uk)
  • This cardiostimulant effect is mediated by an increase in Ca 2+ permeability resulted from cyclic AMP-dependent phosphorylation of voltage-gated ion channels (Figure 1). (springer.com)
  • Hashii, M., Minabe, Y. and Higashida, H., 2000, Cyclic ADP-ribose potentiates Ca 2+ elevation and Ca 2+ entry via L-type voltage-activated Ca 2+ channels in NG108-15 neuronal cells. (springer.com)
  • We show that the model successfully recapitulates the cyclic variations in H + , K + , Cl − , and Mal concentrations in the cytosol and vacuole known for guard cells. (plantphysiol.org)
  • Cyclic ADP-ribose modulated Ca2+ release channels for activation by physiological Ca2+ entry in Bullfrog. (nii.ac.jp)