An analgesic with mixed narcotic agonist-antagonist properties.
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
A semisynthetic derivative of CODEINE.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
An exaggerated feeling of physical and emotional well-being not consonant with apparent stimuli or events; usually of psychologic origin, but also seen in organic brain disease and toxic states.
Strong dependence, both physiological and emotional, upon heroin.
Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Disorders related to substance abuse.
Standards of conduct that distinguish right from wrong.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.
Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.
Differences of opinion or disagreements that may arise, for example, between health professionals and patients or their families, or against a political regime.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.
A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
A complex of cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells. Juxtaglomerular cells are modified SMOOTH MUSCLE CELLS found in the walls of afferent glomerular arterioles and sometimes the efferent arterioles. Extraglomerular mesangium lacis cells are located in the angle between the afferent and efferent glomerular arterioles. Granular epithelial peripolar cells are located at the angle of reflection of the parietal to visceral angle of the renal corpuscle.
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
Removal of a drug from the market due to the identification of an intrinsic property of the drug that results in a serious risk to public health.
A subnormal level of BLOOD PLATELETS.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.

8-Carboxamidocyclazocine: a long-acting, novel benzomorphan. (1/42)

To obtain benzomorphans with a longer duration of action that may be potential therapeutics for treating cocaine abuse, 8-carboxamidocyclazocine was synthesized. The pharmacological properties of 8-carboxamidocyclazocine were compared with the parent compound cyclazocine. Changing the 8-hydroxyl group on cyclazocine to an 8-carboxamido group resulted in only a 2-fold decrease in the affinity of the compound for the kappa-receptor, and no change in the affinity for the mu-opioid receptor, with both compounds having K(i) values of less than 1 nM, based on radioligand binding assays. In the guanosine 5'-O -(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding assay, the two compounds produced moderate stimulation of GTP binding to the human kappa- and mu-receptors. When given by i.c.v. injection, the compounds produced less than 60% antinociception in the mouse 55 degrees C warm-water tail-flick test. However, in the mouse writhing test, the compounds had high potency in producing antinociception. Antinociception induced by either 8-carboxamidocyclazocine or cyclazocine was mediated by both kappa- and mu-opioid receptors. Cyclazocine acted as a mu-antagonist in addition to its agonist properties at the mu-receptor, as measured by the inhibition of morphine-induced antinociception. In contrast, 8-carboxamidocyclazocine did not inhibit morphine-induced antinociception, demonstrating that it was not a mu-opioid receptor antagonist in this assay. An i.p. injection of an ED(70) dose of 8-carboxamidocyclazocine produced antinociception that lasted for 15 h in contrast to cyclazocine, which produced antinociception, lasting 2 h. 8-Carboxamidocyclazocine is a novel, long-acting benzomorphan, which possesses pharmacological properties that are distinct from the properties of cyclazocine.  (+info)

Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia. (2/42)

BACKGROUND AND PURPOSE: Excitatory amino acids and their receptors are involved in mediating ischemic neuronal damage. The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective, hypothermic, and motor deficit effects of the sigma-agonist SKF 10,047 and the N-methyl-D-aspartate antagonist MK-801. METHODS: Neuroprotective effects were compared using an in vitro ischemia model of cultured rat cerebellar granule cells and the gerbil model of global brain ischemia induced by 5 minutes of bilateral carotid artery occlusion followed by 7 days of reperfusion. RESULTS: In vitro, (+)MK-801 protected against 100 microM glutamate with a 50% protective concentration of 30 nM, followed by (-)MK-801 (150 nM), cyclazocine (0.5 microM), (+)SKF 10,047 (3.3 microM), pentazocine (5 microM), and (-)SKF 10,047 (10 microM). In vivo, (+)SKF 10,047 pretreatment (60 mg/kg) or multiple postischemic treatments provided neuroprotection comparable with MK-801 pretreatment (10 mg/kg). When ischemic animals were administered the multiple dosing regimen of (+)SKF 10,047, no hypothermic effect was noted in the temporalis muscle over 4 hours' postischemia. Motor deficits monitored by a swing grid test showed that 50% recovery from (+)SKF 10,047 was 5.5 times faster than recovery from MK-801. CONCLUSIONS: These results are the first to report a hypothermia-free, in vivo neuroprotective effect of (+)SKF 10,047, a prototypical drug of the sigma-agonist class.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC. (3/42)

A series of aryl-containing N-monosubstituted analogues of the lead compound 8-[N-((4'-phenyl)-phenethyl)]-carboxamidocyclazocine were synthesized and evaluated to probe a putative hydrophobic binding pocket of opioid receptors. Very high binding affinity to the mu opioid receptor was achieved though the N-(2-(4'-methoxybiphenyl-4-yl)ethyl) analogue of 8-CAC. High binding affinity to mu and very high binding affinity to kappa opioid receptors was observed for the N-(3-bromophenethyl) analogue of 8-CAC. High binding affinity to all three opioid receptors were observed for the N-(2-naphthylethyl) analogue of 8-CAC.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine. (4/42)

 (+info)

Effects of eptazocine, a novel analgesic, on KCN-induced changes in the cerebral contents of glycolytic metabolites and high-energy phosphates in mice. (5/42)

Effects of eptazocine on cerebral metabolic changes due to a sublethal dose of KCN were investigated in mice. KCN (2 mg/kg, i.v.) induced a temporary loss of consciousness being moderated by eptazocine (1-10 mg/kg) in a dose-dependent manner. The KCN injection decreased the contents of phosphocreatine (PCr), ATP and glucose and increased the contents of AMP and lactate, resulting in a 34% decrease in energy charge potential (ECP) and an increase in lactate/pyruvate (L/P) ratio. Such changes were improved by eptazocine (10 mg/kg) and EKC (3 mg/kg), but not by pentazocine (10 mg/kg) and morphine (3 mg/kg), and the improving effect of eptazocine was completely inhibited by MR-2266 (3 mg/kg), a relatively selective opioid kappa-receptor antagonist. On the other hand, eptazocine (3, 10 mg/kg) was found to increase the glucose content in normal mice, but not to give significant changes in the contents of glycolytic metabolites and high-energy phosphates. These results suggest that eptazocine may improve anoxic changes in cerebral energy metabolism.  (+info)

Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. (6/42)

The well characterized human breast cancer cell line, MCF-7, has been shown to possess membrane receptors for various opioid ligands, and these compounds have been shown to modulate the growth of the cells in culture. Using specific radioligands for the receptor types, we were able to demonstrate that the MCF-7 cells possess multiple opioid receptor types. Relatively high-affinity-binding sites are present for the mu- and kappa-specific ligands, while lower affinity sites are present for the delta-agonist. Opioid ligands specific for the different receptor types significantly inhibited the growth of the MCF-7 cells in a dose-dependent manner when grown in the presence of 10% fetal bovine serum. This inhibitory effect was reversed by the simultaneous administration of the opioid receptor antagonist, naloxone. However, the opioid effect appears to be restricted to the hormonally responsive fraction of the MCF-7 cell growth. Cells grown in the presence of charcoal-stripped fetal bovine serum are refractory to the effects of the opioids unless the media is supplemented with estradiol. The data presented here suggest an important regulatory role for opioids in the growth and development of human breast cancers.  (+info)

Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. (7/42)

1. Opioid receptors in the neonatal rat spinal cord have been characterized by measurements of ligand binding to crude membrane fractions and by functional tests on the nociceptive spinal response in a spinal cord-tail preparation in vitro. 2. There were high affinity binding sites for [3H]-[D-Ala2, MePhe4, Gly(ol)5]enkephalin (DAGOL), [3H]-U69593, and [3H]-ethylketocyclazocine (EKC) on spinal cord membranes from neonatal rats. Hill slopes for binding of [3H]-DAGOL and [3H]-U69593 were close to unity. The Hill slope for binding of [3H]-EKC was less than unity, even after its interactions at mu-receptors had been blocked with 100 nM unlabelled DAGOL. Binding sites for [3H]-[D-Pen2, D-Pen5]enkephalin (DPDPE) could not be detected. 3. In competition assays U50488 was as potent as PD117302 and U69593 in competition for either [3H]-U69593 or [3H]-EKC binding sites. Hill slopes for a range of competing ligands at [3H]-DAGOL or [3H]-U69593 sites were close to unity. Hill slopes for competition at [3H]-EKC sites were less than one. 4. In the spinal cord-tail preparation from neonatal rats, opioid receptor agonists depressed spinal nociceptive responses evoked by application of capsaicin or heat to the tail. The order of potency was DAGOL greater than U69593 = PD117302 greater than morphine greater than U50488 = [D-Pen2, L-Pen5]enkephalin (DPLPE). 5. The antagonist naloxone was about equally potent against DAGOL, morphine and DPLPE, and about ten times less potent against U69593 and PD117302. The effects of U50488 were much less sensitive to blockade by naloxone than the effects of PD11703 or U69593. The Kappa antagonist, nor-binaltorphimine was equipotent against all three Kappa agonists. 6. The absence of delta-binding sites, and the low potency and relatively high sensitivity to naloxone suggest that DPLPE could be working at mu-receptors in the neonatal rat spinal cord. 7. The binding assays show that U50488 has the same affinity as PD1 17302 and U69593 for Kappa-receptors, yet it was less effective in the depression of nociceptive responses. This may be because U50488 has a relatively low efficacy at Kappa-receptors. It is possible that at high concentrations U50488 activates receptors not affected by other Kappa-ligands. These additional receptors may be non-opioid receptors (hence the insensitivity to naloxone), or they could be a subtype of Kappa-opioid receptor.  (+info)

On the mechanism by which midazolam causes spinally mediated analgesia. (8/42)

The electrical current thresholds for pain (ECTP) in the skin of the neck and tail were measured in rats with chronically implanted lumbar subarachnoid catheters. The effects of a benzodiazepine antagonist and a gamma-aminobutyric acid (GABA) antagonist on the analgesic effects of equivalent doses of midazolam, fentanyl, and ketocyclazocine were studied. These were the minimum doses producing maximal segmental analgesia when given intrathecally (i.e., they all caused a significant and maximum increase in ECTP in the tail, which was similar for all three drugs, but no significant change in the ECTP in the neck). Flumazenil (Ro 15-1788) administration caused a parallel shift to the right of the dose-response curve for midazolam spinal analgesia. Segmental analgesia following midazolam was also significantly attenuated (P less than 0.05) when the selective GABA antagonist bicuculline was given intrathecally at the same time as midazolam. The highest dose of bicuculline used (50 pmol) caused no significant attenuation of the segmental analgesic effects of either ketocyclazocine or fentanyl. The authors concluded that the segmental analgesia produced by intrathecal midazolam is mediated by the benzodiazepine-GABA receptor complex that is involved in other benzodiazepine actions.  (+info)

Define cyclazocine. cyclazocine synonyms, cyclazocine pronunciation, cyclazocine translation, English dictionary definition of cyclazocine. n an opiate antagonist used to inhibit the effects of morphine or heroin
Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, naloxone is devoid of any psycho
Don Mares, Executive Director of Denver Human Services presented the proclamation for Redefining Possible Day on behalf of Denver Mayor Michael Hancock. The City of Denver is proud to recognize this portrait series as a change motivator in our community. Redefining Possible seeks to raise awareness about the reality of disability, and we believe it does just that, said Mares. The groundbreaking portrait series examines the lives of twelve people living with spinal cord and brain injury and showcases the power of the human spirit. The portraits were done by Pulitzer Prize-winning photographer Barry Gutierrez. ...
You searched for: Exhibit Tags redefining Remove constraint Exhibit Tags: redefining Creator Anderson, Otis L. Remove constraint Creator: Anderson, Otis L. Creator United States. Public Health Service. Office of the Surgeon General Remove constraint Creator: United States. Public Health Service. Office of the Surgeon General Format Text Remove constraint Format: Text ...
Originally posted on Shots.net by Ryan Watson The Havas Work Club creative partner offers his opinions on creating brave campaigns at Advertising Week Europe. In this latest piece on Redefining Bravery looking ahead to this evenings ANDYs session at Advertising Week Europe, Havas Work Clubs creative partner, Ben Mooge, offers his thoughts on the theme. Mooge appears this…
Redefining the nation through economic growth and migration: changing rationalities of governance in the Republic of Ireland in Mobilities ...
Ive covered quite a number of songs on my YouTube and I find it a little messy for you guys to look for your favorite pieces that Ive covered. Moreover, Ive received lots of requests on songs which Ive already covered. Therefore, Ive taken some time off to make shortcut, direct links sorted by genre, demographics, popularity, and partially alphabetical all in a Blog for your convenience. It is called Redefining Piano ...
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Try these 5 Bodyweight Moves For A Full Body Cardio Workout using these two different interval set ups! Even when youre short on time you can get in a killer workout!
At this point of time, quality education can not be measured in the number of years one has to spend in school but in the effectiveness of such a teacher-student transformation taking place. Quality education must be free and available to everyone. With excellent school facilities, competent teachers, and all other problems given solutions, I think ten years are enough. Why prolong when the basic needs for school are still to be addressed? Redefining quality of education in the Philippines only takes a common sense. The solution, very simple (much more like of a common sense thing than coming up with a seeming bright idea that will only complicate the situation): equip the school with better facilities, free tuition, eradicate corruption from among the departments high-ranking officials to the lowest, and train teachers to become most competent and increase their salaries. It is a thousand times better to have common sense without education, to quote from Robert Green Ingersoll, than to have ...
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.: The effects of the opt
Available for Android and iOS devices. Taking a dose insufficient to kill the infection can result in the bacteria developing a resistance to them, and drug resistant bacteria are really not a good thing. Because its such a common condition, dont think of does tramadol lose its effectiveness as a death sentence for your sex life. Search for questions Still looking for answers? There were 254 tramadol-related deaths in England and Wales in 2013, and 379 in Florida in 2011. Hood recommends having a physical exam and full discussion with your urologist to determine what might be causing your PE.. Does lose of the effects tramadol tramadol on G, an opioid pain reliever prescribed off, serotoninergic system and opioid receptors system. Anticonvulsant and proconvulsant effects of tramadol, so chromatographic techniques must be effectiveness to detect and quantitate these substances. Which makes doctor; we have a lot of knowledge with Internet access. Syntheses and opioid receptor binding properties ...
NanoLuc luciferase brings new capabilities to research applications such as BRET, Reporter Assays, protein:protein interactions, protein:ligand interactions, protein dynamics, genetically-encoded biosensors and in vivo imaging. The small size and extreme brightness of NanoLuc luciferase make it useful in many situations where other luciferases may fail.
Luxury hotels all over the world are making innovative changes to their luxury offerings in order to attracts guests in a way the competition doesnt.
Editors note: The Post Independent, in conjunction with Valley Life For All, continues a monthly series of profiles about people in our community who have different abilities. Twenty-seven percent
Johns Hopkins University scientists trying to determine why people develop serious mental illness are focusing on an unlikely factor: a common parasite spread by cats. The researchers say the microbes, called Toxoplasma gondii, invade the human brain and appear to upset its chemistry - creating, in some people, the psychotic behaviors recognized as schizophrenia. If tackling the parasite can help solve the mystery of schizophrenia, its a pretty good opportunity … to relieve a pretty large burden of disease, said Dr. Robert H. Yolken, director of developmental neurobiology at the Johns Hopkins Childrens Center. The cause of schizophrenia is unknown, but both genetic and environmental factors likely play a part, according to the National Institute of Mental Health. Yolken is among the researchers worldwide examining whether certain viral infections can increase the risk of developing the illness. Other studies have focused on flu and herpes viruses as possible triggers. (Click here for the ...
Faux queens or bio-queens are often perceived to be in the minority within the LGBT and drag communities world-wide. But there is a growing number of young female performers who adopt drag style, so The Tab spoke to two drag queens in Birmingham to learn more about this interesting new rise of faux drag within drag culture and gay nightlife. We spoke to Amber Cadaverous, an up-and-coming student faux drag queen as well as her male drag mother, China Dethcrash about why more and more young women are experimenting with gender and drag looks.. What is faux drag all about and where did your interest in it come from?. Amber: Faux drag is the same as normal drag. I started watching RuPauls Drag Race when I was 16/17, and I thought I can do this! I started it as an extension of my art. My studies in fine art led me to discover performance art, queer theory and gender politics which is a big part of why I do drag. A lot of girls see Drag Race and think they cant get involved because theyre a ...
As the Clean Power Plan makes its way through the courts, it is important to consider an alternative and achievable policy that can help the U.S. meet its long-term climate commitments under the Paris Agreement. One solution that has the potential to substantially curb greenhouse gas (GHG) emissions is a change in the Energy Independence and Security Act
This paper is a summary of a regional case study on gender, land and decentralisation. The main study has two parts: three portraits of women showing different examples of access to natural resources and local leadership; and a general report based on the portraits and on interviews carried out in seven study sites in Maradi and Zinder regions in Niger ...
A new online game Whats Your Number commissioned by FACT and developed by the Royal College of Art invites people from all over the world to test their own understanding of their working life and the traditional notion of eight hours work, eight hours rest and eight hours play. Users will be encouraged to think about their working life in a new way as they answer a series of questions to reveal their own three-digit number. How many will be the traditional eight, eight, eight ...
In this series of live, 1-hour CME/CE-certified meetings, expert faculty members will present an overview of CRPC and the current treatment landscape with an emphasis on interactive, case vignettes to highlight choice of therapy, toxicity management, and key issues in the multidisciplinary management of different clinical presentations of patients with CRPC in the VHA system.. The goal of this activity is to improve the multidisciplinary care of and education to veterans with CRPC regarding effective treatment options, including newer oral therapies in order to improve clinical outcomes. ...
Imagine if every building in an urban neighborhood has a gasoline-powered generator running to produce electricity instead of relying on an electrical grid from the local utility company. Maybe every balcony in a high-rise building has a little generator churning away to charge cell phones and power TVs. Would that seem odd? Why are so many heating systems single-unit sized? When thinking of district energy applications and energy transfer pipe, normally a large city comes to mind. District steam systems in New York City and . . .
Here, Mugambi and Kirima provide an African worldview of what a community is and it is encouraging to observe that the gist of what they are saying is the same as Shorters Western definition above. John Mbiti (1969:102) confirms this similarity when he states that an African community is based on kinship through blood and betrothal. It is the kinship which controls social relationships between people in a given group which makes a community.. The community fosters fairness, equality and basic rights for its members and encourages and promotes cultural diversity. Mbiti (1969), who is an authority on African traditional values and worldview, explains the community as that in which the traditional life of an individual cannot exist alone; it can only exist corporately. One owes ones existence to others, including contemporaries and those of past generations. One is part of the whole. The community makes, creates, or even produces the individual, who, in turn, depends on the corporate group ...
The prognosis was grim, and doctors agreed the only course of action was to remove the cancerous tissue, which included his entire tongue. Desperate to preserve his quality of life, Grant undertook an alternative treatment of aggressive chemotherapy and radiation. But the choice came at a cost. Skin peeled from the inside of Grants mouth and throat, he rapidly lost weight, and most alarmingly, he lost his sense of taste. Tapping into the discipline, passion, and focus of being a chef, Grant rarely missed a day of work. He trained his chefs to mimic his palate and learned how to cook with his other senses. As Kokonas was able to attest: The food was never better. Five months later, Grant was declared cancer-free, and just a few months following, he received the James Beard Foundation Outstanding Chef in America Award ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
SRC supports the U.S. government and our allies with services that ensure mission success. With more than 60 years of experience and reputation for solving the impossible, we are ready tackle the most challenging problems with relentless determination and deep roots in engineering, information, science and technology.
I co-hosted a dialogue recently sponsored by Net Impact. Our group at the Table4Twelve program was diverse and represented a decent cross-section of who works in tech. Yet, I left feeling uneasy. As someone whos benefited from my model minority-ness, I continue to ask myself what can I do to change the equation for others?…
There is increased call for inclusion and diversity in architecture. This London exhibition profiles five female architects and urban designers at the forefront of their profession.
American Heritages collection features Gettysburg, a medium style with a UV Cured Urethane finish, for floor and wall applications with rich dual designer tones.
Sustainable. Locally Grown. Humane. Family Farmed. These are the principles that Open Farm lives and works by. By redefining whats important as a company, Open Farm is redefining pet food. Open Farm is a Canadian family-run business that believes the best ingredients are grown and raised by farmers who respect the lan
Carter said he was surprisingly at ease when he received his diagnosis. Perhaps part of that serenity comes from the knowledge of the good works he has done in his life.
The MetS is a major health concern in the United States today being more prevalent in older individuals and in populations of specific racial/ethnic backgrounds. Although MetS is defined by a clustering of metabolic abnormalities including hyperglycemia, high blood pressure and central obesity, we propose the addition of pro-inflammatory adipokines (TNF-α, IL-6, Leptin, PAI-1) as well as CRP being incorporated into the physiological evaluation of those at risk for MetS. Much research exists to show that hyperinsulinemia and central obesity are integral to the development of MetS and that inflammatory adipokines and cytokines are increased in response to the development of insulin resistance and central obesity. However, questions remain as to whether or not these are the primary contributors or sole antecedents to the development of MetS. Androgenic steroids have also been proposed to contribute to the pathogenesis of MetS. More research is necessary to determine whether insulin resistance and ...
Charles Buchwalter, SVP, Nielsen Online, and Jon Gibbs, SVP, Nielsen Analytics and Insight, were joined by Jeffrey Holecko, media manager, Kimberly-Clark, to discuss the keys to defining a successful online ad campaign.
Transforming Teaching and Learning in Higher Education: Towards a Socially Just Pedagogy in a Global Context, Springer , Palgrave Critical University Studies, p.175-190 (2017 ...
Engineers, manufacturers, utilities, public and private enterprise, commerce - in fact, anyone that uses water for temperature control - are, for the most part, quite comfortable in the belief that they are operating an effective and safe water system. But how safe are they really?
Trying to change cultures within banking institutions is never easy, which is why Barclays new chief executive is taking a hard and seemingly Soviet-era approach at the UK bank. The message is clear: Barclays would now like to be seen as a stodgy commercial bank run by a proselytizing Brit.
CMS would have you believe that this is about quality and patient safety. Who can argue with those laudable goals? They are so revered as to be sacred, and with good reason. But dont be fooled. This is cost containment masquerading as quality. As we start to see more and more of these unpreventable never events proliferating, and more and more payors signing on to the concept of not paying for errors you will see that this is really about reducing the total amount that the big payors spend on the care of sick patients, and shifting the risk of caring for the critically ill onto care providers. It is also informative that CMS is focusing on payments to hospitals, which are much more expensive than the payments to physicians, despite the fact that physicians would theoretically be just as sensitive to payment reductions and are in a position to more directly improve the quality of care ...
UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
In this episode of the Brookings Cafeteria podcast, Mark Muro discusses his new report on automation and the workforce. Also, Molly Reynolds explains what is happening in Congress.
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UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
Retention and graduation rates may be good indicators of a college or universitys success, but they have little to do with students personal development as connected learners and contributors to the digital commons.
Bentley Systems, Incorporated, the leading company dedicated to providing comprehensive software solutions for the infrastructure that sustains our world, ...
The pool at the Beijing Olympics is called the Water Cube because of its bubbly blue exterior. But beyond its futuristic look, the pool is designed for fast times - as swimmers proved Sunday by shattering a dozen records.
Prof Lipman recently presented at the 34th Congress of Internal Medicine in Cape Town, South Africa held 18-21 October 2018.. The meeting aimed at medical specialties such as Cardiology, Pulmonology and Critical Care but also provided an excellent academic programme for the general physician.. Prof Lipman was part of an exciting faculty drawn from experts across the international community.. In the video above Prof Lipman discusses therapeutic drug monitoring of β-lactam antibiotics and his optimistic outlook on the global probem of antimicrobial resistance.. ...
Self-care is often described as getting your nails done, drinking a glass of wine and chilling out. Ive seen a lot of posts on how to exercise self-care that mimic these things and I even wrote one myself in my Pretty Girl In College days. One thing Ive learned since then is that is not the only type of self-care the
When I say homeopathic drug, I mean ONLY potencies 12c or above, which contain only molecular imprints that act by a homeopathic mechanism of biological action by binding to the specific pathogenic molecules. I do not consider molecular forms (crude and below 12c) of drugs as homeopathic - whether they are single or mixed. They…
The word pain literally means a highly unpleasant physical sensation caused by illness or injury. If so, what I experienced during the first 3 months of my treatment was something much more than unpleasant or physical. It was a constant affliction that pervaded from the site of injury ie.my right foot upwards to my head. The most agonising moments were when the pain spread stealthily to your mind causing a numbness and freeze hitherto unknown to me in all the 52 years of my life.Being a person prone to resist and disagree with any kind of discomfort this phase of my life taught me many a hard lesson. It set me wondering if one really had to go through such hard times to realise some simple and obviously handy attributes that make life easier and liveable.But I was chosen by some force to know it the hardest way.. My first experience with intense pain was in the naturopathy centre where I took refuge from the merciless and invasive world of modern medicine that I had such unreasonable ...
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4 Moves To Prevent Low Back Pain - Use these 4 activation exercises to get your abs and glutes working and prevent low back pain!
|div class=field field-name-body field-type-text-with-summary field-label-hidden||div class=field-items||div class=field-item even property=content:encoded||p|This paper outlines a theoretical framework to underpin the definitions of fatal child neglect and provides an ecological perspective on prevention.|/p| |/div||/div||/div|
Press Statement from the Malaysian Bar Council: Malaysia is a secular State. The statement made by the Deputy Prime Minister in this 50th year of Merdeka that Malaysia has never been a secular state is startling as it ignores the undisputed constitutional history of the country as well as the social contract by which the multi racial and multi-religious people of this nation came together. The Federal Constitution was a carefully thought out, carefully negotiated document that evolved after much debate and discussion. Some historical context is necessary. In 1956, Tunku Abdul Rahman had headed a Merdeka Mission to London to negotiate for independence. The negotiations were conducted by 4 representatives of the Malay Rulers, 4 representatives of the then Alliance Government and representatives of the British Government. The Reid Commission was then appointed to draft a constitution for independent Malaya. The Reid Commission held 118 meetings in Malaya. It met a wide cross-section of people ...
This session aims to foster collective reflection on different challenges and opportunities of youth-adult collaboration in community-engaged research. It draws on our decade-long experiences in action-research projects with young people in Montreal. We will share insights from our most recent work with a group of youth co-researchers, which explore issues related to the impacts of the COVID-19 pandemic, as part of a longitudinal study on children growing up with cities.. Issues to be discussed include: the ethics of collaboration; figuring out appropriate types of supportive roles for adults; and more broadly, the multiple benefits of involving youth as co-researchers from the perspective of community youth development and urban planning, as well as for different sectors including schools, municipalities and community organizations.. ...
To the Editor:. As breast cancer continues to pose a major health risk for women, we can ill afford to engage in semantic arguments about what we should call cancer.. A simple name change for ductal carcinoma in situ of the breast should not unravel decades of clinical trial work dealing with its management. Simply put, we cannot predict which lesions will progress (the majority) versus those that are unlikely to progress (a small subset, primarily in older patients).. What the medical community needs is better class prediction based upon a functional understanding of the individual genomic mechanisms involved. Downgrading all ductal carcinoma in situ to indolent lesions of epithelial origin or pre-cancer makes us fear that insurers will stop paying for lifesaving treatments like radiation therapy, anti-estrogen therapy or, on occasion, mastectomies.. It is the physicians responsibility to chart a critical course of treatment for his patients based on each womans circumstances. Our best chance ...
The success of the Call of Duty franchise gave the games industry a reason to celebrate, said Jason Rohrer, the indie developer behind such experimental games like Between, speaking at the Gamasutra-attended Montreal International Games Summit.. With tens of millions of units sold and billions of dollars generated, Call of Duty has led game advocates to point out just how big and mainstream interactive entertainment has become.. But when you compare unit sales of even the biggest games to a recent hit film like Avatar, games still pale in comparison. And when population and monetary inflation is taken into account, games look even worse -- Rohrer did his own number crunching and determined Gone with the Wind had about 1 billion viewers when the world population was only 2 billion people.. He wasnt trying to take the wind out of the games industrys sails, but he was just pointing out that We cant celebrate our conquest of the mainstream quite yet.. Rohrer referred to writer Tom Bissell, ...
Media coverage, proposed legislation, and lexicons influence how the general public views and defines genetic cloning. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
The Clinical And Metabolic Foundation: The Acute Phase Response - Definition However beautiful the strategy, you should occasionally look at the results -Winston Churchill At the time I first became involved with clinical nutrition, which was 1979 in my dental practice, it was very much in vogue for authors and lecturers in this field to…
MIT or Molecular Imprints Therapeutics refers to a scientific hypothesis that proposes a rational model for biological mechanism of homeopathic therapeutics. According to MIT hypothesis, potentization involves a process of molecular imprinting, where in the conformational details of individual drug molecules are imprinted or engraved as hydrogen-bonded three dimensional nano-cavities into a supra-molecular matrix of…
by Olaf Immanuel Seel (Ionian University of Corfu, Greece) Description Culture has a significant influence on the emerging trends in translation and i...
The current description of the function of the human androgen receptor (AR), as a transcription factor directing androgen responsive gene expression, is limited in scope and thus is unable to account for the varied cellular and physiological transformation observed in the development and progression of prostate cancer (CaP). The chapter will focus on four important aspects of AR and CaP investigations: (1) a description of AR somatic mutations and the perils of AR-directed therapeutics; (2) our characterization of AR protein interactors that have imbued new functional properties for AR linked to prostatic disease; (3) review of the advances made and shortcomings of AR mouse models in describing CaP onset and progression; and (4) speculate as to the mechanisms by which new mutations can originate and initiate disease onset.
On Jul 22-23 I participated in a Fermenting workshop with Sandor Katz, the author of The Art of Fermentation and Wild Fermentation. Shelburne Farms, just outside Burlington, Vermont hosted the event. If youve been to Shelburne Farms before, we were in the Coach Barn for the event. Over two days we covered the basics of…
Heres a blog post I wrote today - you or someone you love suffers from memory loss, you will be interested to read this. http://www.donnathomson.com/2012/11/redefining-dementia-lets-all-go-to.html PS: I usually post in Child Neuro, but I was inspired to write this today.
This Essay builds on prior work examining the role the law plays in fostering or discouraging nurturing relationships between fathers and children. In Beyond Ec
From the periphery, Ethiopian Muslim protesters have recently turned a page in the history of the country. They have proven that demonstrations by religious groups can be peaceful, that secularism can be the aim of these groups instead of their nemesis and that a radical Islamist agenda doesn't have to be the dominant one.
Abstract Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. A more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. In this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. We describe the age-related upregulation of nuclear factor (NF)-κB signaling, cytokines/chemokines, endoplasmic reticulum (ER) stress, inflammasome, and lipid accumulation. ...
Advances the understanding of complex social-ecological systems with new insights into ecosystem management practices and long-term sustainability
Yellowstones hot spring organisms broadened our understanding of life and changed the way scientists thought about the prospects for life on Mars and beyond. - Faye Flam, Philadelphia Inquirer
The validity of the conclusions and recommendations of the Quebec Task Force regarding the natural course and epidemiology of whiplash injuries is questionable. This lack of validity stems from the presence of bias, the use of unconventional terminology, and conclusions that are not concurrent with …
Jacqueline Culleton interviews the great plant-based pioneer Bruno Loubet who led the way for many other chefs who were interested in a different way of cooking
Since the birth of the computer age, the drive to bring products to market faster, better and cheaper has been a shared, unparalleled competitive pressure across every engineering design project, regardless of its size or purpose.While the rapid advances in computer power and technology over the past decade have ushered in such powerful technology drivers as CAD (Computer-Aided Design) and CAE (Computer-Aided Engineering), the greatest engineering design productivity bottleneck for most design projects still remains at the human level ...
Sounds like we are gonna get a little crazy with this post, hmmm? Revolution in the streets!? Only in your minds, my friends. Just like my last meditation about Yoga, this time around I got far more than I was expecting. I am loving the flow of information and the unexpected direction of it all.…
konfirmi) Tifluadom [1] estas benzodiazepin derivaĵo kun nekutima agadprofilo. Male al la plej multaj benzodiazepinoj, tifluadom havas neniun agadon ĉe la GABAA receptoro, sed anstataŭe estas selektema agonisto por la κ-opioid receptoro. [2] En konformo, ĝi havas potencan kontraŭdolorilon [3] kaj urinigaj [4] efikoj en bestoj, kaj ankaŭ havas sedativajn efikojn kaj stimulas apetiton.. Dum tifluadom havas plurajn efikojn kiuj eble havos eblajn uzojn en medicino kiel ekzemple analgezio kaj apetitstimulo, κ-opioid agonistoj tendencas produkti nedezirindajn efikojn en homoj kiel ekzemple disforio kaj halucinoj, kaj tiel tiuj medikamentoj tendencas nur esti uzitaj en scienca esplorado. Disforaj efikoj estas similaj al tiuj viditaj kiam uzado de aliaj κ-opioid receptoragonistoj kiel pentazocino kaj salvinorin A.. ...
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione,
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl formate,68683-22-7 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Search for free and find new suppliers for chemical products, pharmaceuticals and APIs.
Matador is a travel and lifestyle brand redefining travel media with cutting edge adventure stories, photojournalism, and social commentary.
Matador is a travel and lifestyle brand redefining travel media with cutting edge adventure stories, photojournalism, and social commentary.
Technology blogger Robert Scoble attended the World Economic Forum at Davos, and made quite a few video recordings of the conversations he had with various people while he was there, which he has uploaded to Qik. In this film, Scoble talks to the Brazilian neuroscientist Miguel Nicolelis, who discussed his recent experiments in which a monkey with a brain-computer interface implanted into its motor cortex controlled the movements of a robot that was located more than 7,000 miles away. Nicolelis presented his results during a session called Redefining the limits of the human body, which included Emory Brown, a computational neuroscientist at MIT, and Hugh Herr, the director of MITs Biomechatronics Group. In this 14-minute film, Scoble talks to Brown, Herr, and Cynthia Breazeal, who heads the Personal Robotics Group (also at MIT). The World Economic Forum YouTube channel includes videos of talks given by British Prime Minister Gordon Brown, Afghani President Hamid Karzai, U.S. Secretary of State ...
Primary Goal in Life: To be the 3rd nicest person in the Universe. I achieve this goal by constantly redefining the word nicest, which is currently 8735 words long in all its nuances and handling special incidents such as road rage and being attacked by wildlife. I wake up every day looking forward to the next friend that I will make, the piece of art that I will create, and the culinary discovery that makes my taste buds tumble. I not only have favorite pieces of music, I have favorite notes within those pieces ...
Buoyed by delivering transformational outcomes in patient health and cost savings, Virta is experiencing surging demand from large employers, health plans, and government entities. Organizations are eager to add reversal solutions to their benefits portfolios, driving Virtas growth rate to nearly 200% year over year. Virta works with over 100 organizations, and treats patients in all 50 states. Virta is redefining how diabetes and other chronic diseases should be cared for, delivering significantly better health outcomes and impressive cost savings, said Scott Shleifer of Tiger Global. We are excited to partner with Virta as its pioneering approach becomes an invaluable benefit offering for more employers and health plans everywhere. Nearly half of U.S. adults suffer from type 2 diabetes or prediabetes. Despite trillions of dollars spent on diabetes and related conditions over the past decade, there has been no improvement in population-level outcomes. The COVID-19 pandemic has made matters ...
Sensory perception comprises gustatory (taste) and olfactory (smell) modalities as well as somatosensory (pain, heat, and tactile mechanosensory) inputs, which are detected by a multitude of sensory receptors. These sensory receptors are contained in specialized ciliated neurons where they detect changes in environmental conditions and participate in behavioral decisions ranging from food choice to avoiding harmful conditions, thus insuring basic survival in metazoans. Recent genetic studies, however, indicate that sensory perception plays additional physiological functions, notably influencing energy homeostatic processes and longevity through neuronal circuits originating from sensory tissues. Here we review how these findings are redefining metabolic signaling and establish a prominent role of sensory neuroendocrine processes in controlling health span and lifespan, with a goal of translating this knowledge towards managing age-associated diseases. PMID: 27067041 [PubMed - indexed for ...
Many authors have insisted on the necessity of defining poverty as a multi-dimensional concept rather than relying on income or consumption expenditures per capita. Yet, not much has actually been done to include the various dimensions of deprivation into the practical definition and measurement of poverty. Existing attempts along that direction consist of aggregating various attributes into a single index through some arbitrary function and defining a poverty line and associated poverty measures on the basis of that index. All this is merely redefining the more general concept of poverty, which then essentially remains a uni-dimensional concept. On the contrary, the present paper suggests that the only way to truly take into account the multi-dimensionality of poverty is to specify a poverty line for each dimension of poverty and to consider that a person is poor if he/she falls below at least one of these various lines. The paper then explores ways to combine these various poverty lines and associated
Musically, the Beatles managed the unparalleled feat of both crystallizing and redefining music over the course of its decade as a band. Their discography is a jukebox of infectious pop music blended with freewheeling experimental and eclectic impulses, especially heard from their 1967 Sgt. Peppers Lonely Hearts Club Band to 1969s Abbey Road. They wanted to change the music world while also embracing its traditional values.. On a humbler level, the Beatles cinematic legacy has achieved a similar balance of emotionality and envelope-pushing audacity. As such, their cinematic oeuvre is the subject of an enticing free-to-the-public film series at UCSBs Carsey-Wolf Center, Beatles Revolutions. The series spans a course of five films made during and after the Beatles life as a band and features special guest speakers, including Beatles engineer Alan Parsons and famed rock critic Greil Marcus.. The screenings are as follows: A Hard Days Night, with biographer Ivor Davis (January 17); Let It Be, ...
Eagle has always stood as the benchmark for excellence in strength machines. Now were redefining what it means to be the best with refined movements, restyled aesthetics, and reimagined user features. The Cybex Eagle NX Overhead Press is made up of fifteen premium and unique pieces of strength training equipment designed to transform your facility and their workouts.. Aesthetically sophisticated yet highly durable, the Cybex Eagle NX Overhead Press is built to withstand rigorous movement yet gentle on the joints, and designed for all fitness levels yet focused on individual results, Cybex Eagle NX Overhead Press provides an unparalleled workout experience. Strength training has evolved beyond the number of pounds bench-Curled and reps crunched. Today, its about burning calories, building lean muscle, improving bone density, and managing chronic conditions. The strength training revolution has begun and nowhere is that more evident than with the Eagle NX strength line from Cybex.. ...
Im here to bring a ginormous spotlight to an area of health and healing thats being overlooked: unresolved and untreated trauma (of all kinds!).. Before you say, I wasnt traumatize, please, please stick around because we, the scientific and clinical practice community, are finally redefining what a traumatic experience and adversity really is and it is not what most people think! I am here to give everybody access to education that is NOT dumbed down and assumes the reader wants the truth - even if it means getting into the nitty-gritty and feeling some feels. This means my articles (and videos that often accompany them) are more on the in-depth side and require you to think a bit more. In some cases a lot more. I hope you take some time to sink your curiosity into all that is on this page.. Much Love. ...
Downloadable (with restrictions)! Many authors have insisted on the necessity of defining poverty as a multi-dimensional concept rather than relying on income or consumption expenditures per capita. Yet, not much has actually been done to include the various dimensions of deprivation into the practical definition and measurement of poverty. Existing attempts along that direction consist of aggregating various attributes into a single index through some arbitrary function and defining a poverty line and associated poverty measures on the basis of that index. All this is merely redefining the more general concept of poverty, which then essentially remains a uni-dimensional concept. On the contrary, the present paper suggests that the only way to truly take into account the multi-dimensionality of poverty is to specify a poverty line for each dimension of poverty and to consider that a person is poor if he/she falls below at least one of these various lines. The paper then explores ways to combine these
Redefining the traditional scope of documentary film in an electronic age, 65_RedRoses leaves viewers with a new appreciation of life and the digital world. This personal and touching journey takes an unflinching look into the lives of Eva Markvoort and her two online friends who are all battling cystic fibrosis (CF) - a fatal genetic disease affecting the lungs and digestive system.. Unable to meet in person because of the spread of infections and super bugs, the girls have become each others lifelines through the Internet, providing unconditional love, support and understanding long after visiting hours are over. Now at a critical turning point in their lives, the film travels the distance the friends cannot go themselves, capturing the compelling and often heartbreaking realities they face, just trying to take each breath.. ...
  • Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. (wikipedia.org)
  • These include cyclazocine, pentazocine, and phenazocine. (wikipedia.org)
  • The narcotic analgesics morphine, codeine, meperidine and methadone and the narcotic antagonist analgesics cyclazocine, cyclorphan, nalorphine and pentazocine were active. (aspetjournals.org)
  • NARCAN (naloxone) is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids, including propoxyphene, methadone and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine. (rxlist.com)
  • They are distinguished from sigma2 receptors as they have high affinity and stereoselectivity for the (+)-isomers of pentazocine, SK&F 10047 and cyclazocine, and different subcellular localizations. (genecards.org)
  • f)cyclazocine, and (-)pentazocine and also for some narcoleptics such as haloperidol. (allindianpatents.com)
  • Further lending credence to the exorphin dysfunction hypothesis are studies using "mixed agonist/antagonists" drugs (e.g., cyclazocine and nalorphine) that artificially stimulate and suppress the body's endorphin receptors and have been known to produce profound dysphoria bordering on psychosis in patients. (thefreedictionary.com)
  • Gluten therefore, by its "molecular mimicry" of endorphins (and enkephalins) reacts with the brain's endorphin receptors in the same deleterious way as cyclazocine or nalorphine. (thefreedictionary.com)
  • Haertzen, C. A.: Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Centre Inventory (ARCI). (springer.com)
  • Both cyclazocine and nalorphine inhibit cAMP accumulation in COS-7 cells stably expressing the clone. (aspetjournals.org)
  • Morphine stimulus properties did not generalize to nalorphine or cyclazocine, which produce dissimilar subjective effects. (meta.org)
  • The stimulus properties of LSD generalized partially to cyclazocine, but not to nalorphine. (meta.org)
  • In humans cyclazocine and nalorphine produce a high incidence of psychotomimetic effects, but the subjective effects of cyclazocine are differentiable from those of LSD. (meta.org)
  • The agonist/antagonists, butorphanol and cyclazocine, when injected, behaved like kappa agonists and increased plasma corticosterone levels potently. (aspetjournals.org)
  • Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. (erowid.org)
  • Increasing the training dose of morphine shifted the morphine gradient to the right, increased the antagonist effects of cyclazocine and of l-NANM, and decreased their agonist effects, but did not alter the effects of ketamine. (umich.edu)
  • Benzomorphans I-cyclorphan(3a) Mu-antagonist girlfriend agonist dextromethorphan HO HJ O Cyclazocine (2) Cheap Mastigra 100mg In UK 2033 Bremazocine o HO Fig. (obyxova.ru)
  • A psychiatrist who has had experience with both methadone and antagonist maintenance programs contrasts 'the relaxed, jovial atmosphere of a methadone ward,' where patients are free of the postaddiction syndrome, with 'the tension, frustration, and anxiety that characterize a cyclazocine ward. (druglibrary.org)
  • Specific [ 3 H]phencyclidine binding can be displaced by cyclazocine (IC 50 = 350 nM) and by related benzomorphans, but not by classical opiates such as morphine or naloxone. (elsevier.com)
  • The generalization gradient of cyclazocine and of l-NANM, but not that of ketamine, was less steep than the gradient of morphine. (umich.edu)
  • Cyclazocine and l-NANM, but not U50,488 and ketamine, antagonized partially the discriminative stimulus (DS) effects of morphine. (umich.edu)
  • The full generalization produced by cyclazocine when the training dose of morphine was lowered could be blocked completely by naltrexone and l-NANM, but not by ketamine. (umich.edu)
  • These results suggest that cyclazocine and l-NANM, but not ketamine, produced partial generalization because of their low efficacy at the receptor that underlies the DS effects of morphine. (umich.edu)
  • 1986 Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo. (takecarehomehealth.com)
  • Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro study. (semanticscholar.org)
  • article{Thomson1985SelectiveBO, title={Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro study. (semanticscholar.org)
  • In isolated slices of rat cortex, intracellularly recorded responses of pyramidal neurones to N-methylaspartate (NMA) and glutamate and responses to stimulation of the underlying white matter were compared and challenged with the sigma opiate cyclazocine. (semanticscholar.org)
  • Interaction of the psychotomimetic opiate cyclazocine with multiple receptor sites has been demonstrated biochemically. (elsevier.com)
  • Jaffe, J. H., Brill, L.: Cyclazocine, a long acting narcotic antagonist: its voluntary acceptance as a treatment modality by narcotics abusers. (springer.com)
  • Claim 1 of auxiliary request IIc differs from claim 1 of auxiliary request IIb in that the feature 'and wherein the opioid antagonist is selected from the group consisting of naloxone, nalmephene, cyclazocine, levallorphan, naltrexone and mixtures thereof' has been added. (epo.org)
  • 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine. (nih.gov)
  • Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine. (nih.gov)
  • Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting treatment of narcotic addiction was severely hampered by the drug's psychotomimetic, dysphoric, and hallucinatory effects. (wikipedia.org)
  • Related drugs include phenazocine, dezocine, cyclazocine and several chemicals used in research on the central nervous system. (dbpedia.org)
  • Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established discriminated (Sidman) avoidance performance in rats. (springer.com)
  • The effects of cyclazocine and LSD in rats may be mediated through similar mechanisms. (springer.com)
  • The most recent study of cyclazocine, reported in the International Journal of the Addiction, 3 in 1971, indicates that of 186 addicts offered cyclazocine, 33 accepted, of whom 11 were believed to be abstinent twenty months later. (druglibrary.org)
  • Competition analyses involving rank order determinations for a series of opiates and other drugs indicate that the cyclazocine binding sites represent, in order of decreasing affinity, the classical opiate receptor (the putative 'μ' receptor), a second as yet uncharacterized opiate binding site, and the specific [ 3 H]phencyclidine binding site. (elsevier.com)
  • Cyclazocine has been postulated to interact with μ, κ, and σ opiate receptors (Martin et al. (elsevier.com)
  • The high- and low-affinity [ 3 H]cyclazocine sites exhibit differential sensitivities to sodium and also to the selective sulfhydryl reagent N-ethylmaleimide. (elsevier.com)
  • Replacement of the phenolic hydroxyl group in non-peptide opiates with the −CONH 2 group had previously been shown to result in compounds retaining high μ receptor binding affinity 5 , 6 and introduction of a (4'-phenyl)-phenethyl substituent at the −CONH 2 group of 8-carboxamido-cyclazocine did not diminish μ receptor binding affinity. (pubmedcentralcanada.ca)
  • D-EKC and D-cyclazocine, which bind to sigma sites, had no effect on corticosterone. (aspetjournals.org)
  • Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and colleagues (1970). (wikipedia.org)
  • The study suggests, but does not prove, that the few patients who accept cyclazocine do significantly better than similar patients who attempt abstinence without cyclazocine. (druglibrary.org)
  • "Cyclazocine revisited - Neurochemical Research" 21 (11). (wikipedia.org)

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