DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
CyclazocineReceptors, PhencyclidinePhenazocineNalorphinePentazocineDictionaries, MedicalDictionaries as TopicNaloxoneHallucinationsHydromorphoneHydrocodoneOxymorphoneOxycodoneAnalgesics, OpioidMiosisCodeineOrganophosphonatesPatents as TopicAminationMolecular StructurePhosphorusStructure-Activity RelationshipStereoisomerismEncyclopedias as TopicMedlinePlusConsumer Health InformationSocial MediaDissent and DisputesInternetPeer ReviewDrug LabelingDrugs, GenericSafety-Based Drug WithdrawalsThrombocytopeniaUnited States Food and Drug AdministrationLeiomyomaBlood VolumeDextropropoxypheneDextromoramideEtorphineDihydromorphineMethadyl AcetateNeuronal Tract-TracersColchicineMebendazoleMilieu TherapyDiagnostic and Statistical Manual of Mental DisordersDermoscopyHematomaHallucinogensWorld War IIChemical Warfare AgentsLysergic Acid DiethylamideChemical WarfarePsilocybine
Cyclazocine
An analgesic with mixed narcotic agonist-antagonist properties.
Receptors, Phencyclidine
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
Phenazocine
An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)
Nalorphine
A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
Pentazocine
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Naloxone
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Hallucinations
Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.
Hydromorphone
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Hydrocodone
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
Oxymorphone
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Oxycodone
A semisynthetic derivative of CODEINE.
Analgesics, Opioid
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Miosis
Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
Codeine
An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
Organophosphonates
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Amination
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Phosphorus
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
MedlinePlus
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Consumer Health Information
Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.
Social Media
Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.
Dissent and Disputes
Differences of opinion or disagreements that may arise, for example, between health professionals and patients or their families, or against a political regime.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Peer Review
An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Drugs, Generic
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
Safety-Based Drug Withdrawals
Removal of a drug from the market due to the identification of an intrinsic property of the drug that results in a serious risk to public health.
Thrombocytopenia
A subnormal level of BLOOD PLATELETS.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Leiomyoma
A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Blood Volume
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Dextropropoxyphene
A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.
Dextromoramide
An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
Etorphine
A narcotic analgesic morphinan used as a sedative in veterinary practice.
Dihydromorphine
A semisynthetic analgesic used in the study of narcotic receptors.
Methadyl Acetate
A narcotic analgesic with a long onset and duration of action.
Neuronal Tract-Tracers
Substances used to identify the location and to characterize the types of NEURAL PATHWAYS.
Colchicine
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
Mebendazole
A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Milieu Therapy
A treatment program based on manipulation of the patient's environment by the medical staff. The patient does not participate in planning the treatment regimen.
Diagnostic and Statistical Manual of Mental Disorders
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Dermoscopy
A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.
Hematoma
A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
Hallucinogens
Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.
World War II
Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.
Chemical Warfare Agents
Chemicals that are used to cause the disturbance, disease, or death of humans during WARFARE.
Lysergic Acid Diethylamide
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
Chemical Warfare
Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.
Psilocybine
The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)

8-Carboxamidocyclazocine: a long-acting, novel benzomorphan. (1/42)

To obtain benzomorphans with a longer duration of action that may be potential therapeutics for treating cocaine abuse, 8-carboxamidocyclazocine was synthesized. The pharmacological properties of 8-carboxamidocyclazocine were compared with the parent compound cyclazocine. Changing the 8-hydroxyl group on cyclazocine to an 8-carboxamido group resulted in only a 2-fold decrease in the affinity of the compound for the kappa-receptor, and no change in the affinity for the mu-opioid receptor, with both compounds having K(i) values of less than 1 nM, based on radioligand binding assays. In the guanosine 5'-O -(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding assay, the two compounds produced moderate stimulation of GTP binding to the human kappa- and mu-receptors. When given by i.c.v. injection, the compounds produced less than 60% antinociception in the mouse 55 degrees C warm-water tail-flick test. However, in the mouse writhing test, the compounds had high potency in producing antinociception. Antinociception induced by either 8-carboxamidocyclazocine or cyclazocine was mediated by both kappa- and mu-opioid receptors. Cyclazocine acted as a mu-antagonist in addition to its agonist properties at the mu-receptor, as measured by the inhibition of morphine-induced antinociception. In contrast, 8-carboxamidocyclazocine did not inhibit morphine-induced antinociception, demonstrating that it was not a mu-opioid receptor antagonist in this assay. An i.p. injection of an ED(70) dose of 8-carboxamidocyclazocine produced antinociception that lasted for 15 h in contrast to cyclazocine, which produced antinociception, lasting 2 h. 8-Carboxamidocyclazocine is a novel, long-acting benzomorphan, which possesses pharmacological properties that are distinct from the properties of cyclazocine.  (+info)

Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia. (2/42)

BACKGROUND AND PURPOSE: Excitatory amino acids and their receptors are involved in mediating ischemic neuronal damage. The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective, hypothermic, and motor deficit effects of the sigma-agonist SKF 10,047 and the N-methyl-D-aspartate antagonist MK-801. METHODS: Neuroprotective effects were compared using an in vitro ischemia model of cultured rat cerebellar granule cells and the gerbil model of global brain ischemia induced by 5 minutes of bilateral carotid artery occlusion followed by 7 days of reperfusion. RESULTS: In vitro, (+)MK-801 protected against 100 microM glutamate with a 50% protective concentration of 30 nM, followed by (-)MK-801 (150 nM), cyclazocine (0.5 microM), (+)SKF 10,047 (3.3 microM), pentazocine (5 microM), and (-)SKF 10,047 (10 microM). In vivo, (+)SKF 10,047 pretreatment (60 mg/kg) or multiple postischemic treatments provided neuroprotection comparable with MK-801 pretreatment (10 mg/kg). When ischemic animals were administered the multiple dosing regimen of (+)SKF 10,047, no hypothermic effect was noted in the temporalis muscle over 4 hours' postischemia. Motor deficits monitored by a swing grid test showed that 50% recovery from (+)SKF 10,047 was 5.5 times faster than recovery from MK-801. CONCLUSIONS: These results are the first to report a hypothermia-free, in vivo neuroprotective effect of (+)SKF 10,047, a prototypical drug of the sigma-agonist class.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC. (3/42)

A series of aryl-containing N-monosubstituted analogues of the lead compound 8-[N-((4'-phenyl)-phenethyl)]-carboxamidocyclazocine were synthesized and evaluated to probe a putative hydrophobic binding pocket of opioid receptors. Very high binding affinity to the mu opioid receptor was achieved though the N-(2-(4'-methoxybiphenyl-4-yl)ethyl) analogue of 8-CAC. High binding affinity to mu and very high binding affinity to kappa opioid receptors was observed for the N-(3-bromophenethyl) analogue of 8-CAC. High binding affinity to all three opioid receptors were observed for the N-(2-naphthylethyl) analogue of 8-CAC.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine. (4/42)

 (+info)

Effects of eptazocine, a novel analgesic, on KCN-induced changes in the cerebral contents of glycolytic metabolites and high-energy phosphates in mice. (5/42)

Effects of eptazocine on cerebral metabolic changes due to a sublethal dose of KCN were investigated in mice. KCN (2 mg/kg, i.v.) induced a temporary loss of consciousness being moderated by eptazocine (1-10 mg/kg) in a dose-dependent manner. The KCN injection decreased the contents of phosphocreatine (PCr), ATP and glucose and increased the contents of AMP and lactate, resulting in a 34% decrease in energy charge potential (ECP) and an increase in lactate/pyruvate (L/P) ratio. Such changes were improved by eptazocine (10 mg/kg) and EKC (3 mg/kg), but not by pentazocine (10 mg/kg) and morphine (3 mg/kg), and the improving effect of eptazocine was completely inhibited by MR-2266 (3 mg/kg), a relatively selective opioid kappa-receptor antagonist. On the other hand, eptazocine (3, 10 mg/kg) was found to increase the glucose content in normal mice, but not to give significant changes in the contents of glycolytic metabolites and high-energy phosphates. These results suggest that eptazocine may improve anoxic changes in cerebral energy metabolism.  (+info)

Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. (6/42)

The well characterized human breast cancer cell line, MCF-7, has been shown to possess membrane receptors for various opioid ligands, and these compounds have been shown to modulate the growth of the cells in culture. Using specific radioligands for the receptor types, we were able to demonstrate that the MCF-7 cells possess multiple opioid receptor types. Relatively high-affinity-binding sites are present for the mu- and kappa-specific ligands, while lower affinity sites are present for the delta-agonist. Opioid ligands specific for the different receptor types significantly inhibited the growth of the MCF-7 cells in a dose-dependent manner when grown in the presence of 10% fetal bovine serum. This inhibitory effect was reversed by the simultaneous administration of the opioid receptor antagonist, naloxone. However, the opioid effect appears to be restricted to the hormonally responsive fraction of the MCF-7 cell growth. Cells grown in the presence of charcoal-stripped fetal bovine serum are refractory to the effects of the opioids unless the media is supplemented with estradiol. The data presented here suggest an important regulatory role for opioids in the growth and development of human breast cancers.  (+info)

Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. (7/42)

1. Opioid receptors in the neonatal rat spinal cord have been characterized by measurements of ligand binding to crude membrane fractions and by functional tests on the nociceptive spinal response in a spinal cord-tail preparation in vitro. 2. There were high affinity binding sites for [3H]-[D-Ala2, MePhe4, Gly(ol)5]enkephalin (DAGOL), [3H]-U69593, and [3H]-ethylketocyclazocine (EKC) on spinal cord membranes from neonatal rats. Hill slopes for binding of [3H]-DAGOL and [3H]-U69593 were close to unity. The Hill slope for binding of [3H]-EKC was less than unity, even after its interactions at mu-receptors had been blocked with 100 nM unlabelled DAGOL. Binding sites for [3H]-[D-Pen2, D-Pen5]enkephalin (DPDPE) could not be detected. 3. In competition assays U50488 was as potent as PD117302 and U69593 in competition for either [3H]-U69593 or [3H]-EKC binding sites. Hill slopes for a range of competing ligands at [3H]-DAGOL or [3H]-U69593 sites were close to unity. Hill slopes for competition at [3H]-EKC sites were less than one. 4. In the spinal cord-tail preparation from neonatal rats, opioid receptor agonists depressed spinal nociceptive responses evoked by application of capsaicin or heat to the tail. The order of potency was DAGOL greater than U69593 = PD117302 greater than morphine greater than U50488 = [D-Pen2, L-Pen5]enkephalin (DPLPE). 5. The antagonist naloxone was about equally potent against DAGOL, morphine and DPLPE, and about ten times less potent against U69593 and PD117302. The effects of U50488 were much less sensitive to blockade by naloxone than the effects of PD11703 or U69593. The Kappa antagonist, nor-binaltorphimine was equipotent against all three Kappa agonists. 6. The absence of delta-binding sites, and the low potency and relatively high sensitivity to naloxone suggest that DPLPE could be working at mu-receptors in the neonatal rat spinal cord. 7. The binding assays show that U50488 has the same affinity as PD1 17302 and U69593 for Kappa-receptors, yet it was less effective in the depression of nociceptive responses. This may be because U50488 has a relatively low efficacy at Kappa-receptors. It is possible that at high concentrations U50488 activates receptors not affected by other Kappa-ligands. These additional receptors may be non-opioid receptors (hence the insensitivity to naloxone), or they could be a subtype of Kappa-opioid receptor.  (+info)

On the mechanism by which midazolam causes spinally mediated analgesia. (8/42)

The electrical current thresholds for pain (ECTP) in the skin of the neck and tail were measured in rats with chronically implanted lumbar subarachnoid catheters. The effects of a benzodiazepine antagonist and a gamma-aminobutyric acid (GABA) antagonist on the analgesic effects of equivalent doses of midazolam, fentanyl, and ketocyclazocine were studied. These were the minimum doses producing maximal segmental analgesia when given intrathecally (i.e., they all caused a significant and maximum increase in ECTP in the tail, which was similar for all three drugs, but no significant change in the ECTP in the neck). Flumazenil (Ro 15-1788) administration caused a parallel shift to the right of the dose-response curve for midazolam spinal analgesia. Segmental analgesia following midazolam was also significantly attenuated (P less than 0.05) when the selective GABA antagonist bicuculline was given intrathecally at the same time as midazolam. The highest dose of bicuculline used (50 pmol) caused no significant attenuation of the segmental analgesic effects of either ketocyclazocine or fentanyl. The authors concluded that the segmental analgesia produced by intrathecal midazolam is mediated by the benzodiazepine-GABA receptor complex that is involved in other benzodiazepine actions.  (+info)

Cyclazocine - definition of cyclazocine by The Free DictionaryCyclazocine - definition of cyclazocine by The Free Dictionary
Define cyclazocine. cyclazocine synonyms, cyclazocine pronunciation, cyclazocine translation, English dictionary definition of cyclazocine. n an opiate antagonist used to inhibit the effects of morphine or heroin
https://www.thefreedictionary.com/cyclazocine
A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLinkA correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLink
Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, naloxone is devoid of any psycho
https://link.springer.com/article/10.1007%2FBF00421916
Blog | Redefining Possible Day: The Grand Opening of the Portrait Series Redefining Possible - Craig HospitalBlog | Redefining Possible Day: The Grand Opening of the Portrait Series Redefining Possible - Craig Hospital
Don Mares, Executive Director of Denver Human Services presented the proclamation for Redefining Possible Day on behalf of Denver Mayor Michael Hancock. The City of Denver is proud to recognize this portrait series as a change motivator in our community. Redefining Possible seeks to raise awareness about the reality of disability, and we believe it does just that, said Mares. The groundbreaking portrait series examines the lives of twelve people living with spinal cord and brain injury and showcases the power of the human spirit. The portraits were done by Pulitzer Prize-winning photographer Barry Gutierrez. ...
https://craighospital.org/blog/redefining-possible-day-the-grand-opening-of-the-portrait-series
Clarins Super Restorative Redefining Body Care for Abdomen and Waist 200ml/6.9oz price - GoShopping.comClarins Super Restorative Redefining Body Care for Abdomen and Waist 200ml/6.9oz price - GoShopping.com
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The Lanier. Law Firm Redefining Legal Care - PDFThe Lanier. Law Firm Redefining Legal Care - PDF
The Lanier Law Firm Redefining Legal Care The attorneys at The Lanier Law Firm provide something not found at every law firm: Legal Care. We care about clients cases. Our focus is on you and your case,
http://docplayer.net/511299-The-lanier-law-firm-redefining-legal-care.html
5 Bodyweight Moves For A Full Body Cardio Workout | Redefining Strength Redefining Strength5 Bodyweight Moves For A Full Body Cardio Workout | Redefining Strength Redefining Strength
Try these 5 Bodyweight Moves For A Full Body Cardio Workout using these two different interval set ups! Even when youre short on time you can get in a killer workout!
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Redefining quality education: Should the K12 program of the DepEd be the best solution? ~ My JourneyRedefining quality education: Should the K12 program of the DepEd be the best solution? ~ My Journey
At this point of time, quality education can not be measured in the number of years one has to spend in school but in the effectiveness of such a teacher-student transformation taking place. Quality education must be free and available to everyone. With excellent school facilities, competent teachers, and all other problems given solutions, I think ten years are enough. Why prolong when the basic needs for school are still to be addressed? Redefining quality of education in the Philippines only takes a common sense. The solution, very simple (much more like of a common sense thing than coming up with a seeming bright idea that will only complicate the situation): equip the school with better facilities, free tuition, eradicate corruption from among the departments high-ranking officials to the lowest, and train teachers to become most competent and increase their salaries. It is a thousand times better to have common sense without education, to quote from Robert Green Ingersoll, than to have ...
https://nnalcot.blogspot.com/2012/06/redefining-quality-education-should-k12.html
Buy Redefining the French Republic Online at Best Price in India - Buy Books India.Buy Redefining the French Republic Online at Best Price in India - Buy Books India.
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Pharmacodynamic and pharmacokinetic actions of ketocyclazocine...Pharmacodynamic and pharmacokinetic actions of ketocyclazocine...
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.: The effects of the opt
https://www.mysciencework.com/publication/show/pharmacodynamic-pharmacokinetic-actions-ketocyclazocine-enantiomers-dog-absence-sigma-phencyclidine-like-activity-913d2efc
NanoLuc® Luciferase: Redefining Reporter AssaysNanoLuc® Luciferase: Redefining Reporter Assays
NanoLuc luciferase brings new capabilities to research applications such as BRET, Reporter Assays, protein:protein interactions, protein:ligand interactions, protein dynamics, genetically-encoded biosensors and in vivo imaging. The small size and extreme brightness of NanoLuc luciferase make it useful in many situations where other luciferases may fail.
https://www.promega.com/resources/technologies/nanoluc-luciferase-redefining-reporter-assays/
Valley Life for All column: Meet Christie Henderson, redefining the perception of challenge | PostIndependent.comValley Life for All column: Meet Christie Henderson, redefining the perception of challenge | PostIndependent.com
Editors note: The Post Independent, in conjunction with Valley Life For All, continues a monthly series of profiles about people in our community who have different abilities. Twenty-seven percent
https://www.postindependent.com/opinion/columns/valley-life-for-all-column-meet-christie-henderson-redefining-the-perception-of-challenge/
Doc 40: REDEFINING CRAZY CATDoc 40: REDEFINING CRAZY CAT
Johns Hopkins University scientists trying to determine why people develop serious mental illness are focusing on an unlikely factor: a common parasite spread by cats. The researchers say the microbes, called Toxoplasma gondii, invade the human brain and appear to upset its chemistry - creating, in some people, the psychotic behaviors recognized as schizophrenia. If tackling the parasite can help solve the mystery of schizophrenia, its a pretty good opportunity … to relieve a pretty large burden of disease, said Dr. Robert H. Yolken, director of developmental neurobiology at the Johns Hopkins Childrens Center. The cause of schizophrenia is unknown, but both genetic and environmental factors likely play a part, according to the National Institute of Mental Health. Yolken is among the researchers worldwide examining whether certain viral infections can increase the risk of developing the illness. Other studies have focused on flu and herpes viruses as possible triggers. (Click here for the ...
http://doc40.blogspot.com/2010/08/redefining-crazy-cat.html
Redefining renewable biomass: A policy change with cascading outcomesRedefining renewable biomass: A policy change with cascading outcomes
As the Clean Power Plan makes its way through the courts, it is important to consider an alternative and achievable policy that can help the U.S. meet its long-term climate commitments under the Paris Agreement. One solution that has the potential to substantially curb greenhouse gas (GHG) emissions is a change in the Energy Independence and Security Act
https://www.brookings.edu/blog/planetpolicy/2016/03/29/redefining-renewable-biomass-a-policy-change-with-cascading-outcomes/?shared=email&msg=fail
Landless women, hopeless women? Gender, land and decentralisation in Niger | Women Reclaiming and Redefining CulturesLandless women, hopeless women? Gender, land and decentralisation in Niger | Women Reclaiming and Redefining Cultures
This paper is a summary of a regional case study on gender, land and decentralisation. The main study has two parts: three portraits of women showing different examples of access to natural resources and local leadership; and a general report based on the portraits and on interviews carried out in seven study sites in Maradi and Zinder regions in Niger ...
http://www.wluml.org/bibliography/wrrc/content/landless-women-hopeless-women-gender-land-and-decentralisation-niger
Time & Motion: Redefining Working Life | RhizomeTime & Motion: Redefining Working Life | Rhizome
A new online game Whats Your Number commissioned by FACT and developed by the Royal College of Art invites people from all over the world to test their own understanding of their working life and the traditional notion of eight hours work, eight hours rest and eight hours play. Users will be encouraged to think about their working life in a new way as they answer a series of questions to reveal their own three-digit number. How many will be the traditional eight, eight, eight ...
http://rhizome.org/community/22134/
Redefining trauma in an African context: a challenge to pastoral careRedefining trauma in an African context: a challenge to pastoral care
Here, Mugambi and Kirima provide an African worldview of what a community is and it is encouraging to observe that the gist of what they are saying is the same as Shorters Western definition above. John Mbiti (1969:102) confirms this similarity when he states that an African community is based on kinship through blood and betrothal. It is the kinship which controls social relationships between people in a given group which makes a community.. The community fosters fairness, equality and basic rights for its members and encourages and promotes cultural diversity. Mbiti (1969), who is an authority on African traditional values and worldview, explains the community as that in which the traditional life of an individual cannot exist alone; it can only exist corporately. One owes ones existence to others, including contemporaries and those of past generations. One is part of the whole. The community makes, creates, or even produces the individual, who, in turn, depends on the corporate group ...
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0259-94222012000100045&lng=pt&nrm=iso&tlng=en
Redefining stress resistance genes, and why it matters. - PubMed - NCBIRedefining stress resistance genes, and why it matters. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/27702993
Life, on the Line: A Chefs Story of Chasing Greatness, Facing Death, and Redefining the Way We Eat (Hardcover) | Tattered...Life, on the Line: A Chefs Story of Chasing Greatness, Facing Death, and Redefining the Way We Eat (Hardcover) | Tattered...
The prognosis was grim, and doctors agreed the only course of action was to remove the cancerous tissue, which included his entire tongue. Desperate to preserve his quality of life, Grant undertook an alternative treatment of aggressive chemotherapy and radiation. But the choice came at a cost. Skin peeled from the inside of Grants mouth and throat, he rapidly lost weight, and most alarmingly, he lost his sense of taste. Tapping into the discipline, passion, and focus of being a chef, Grant rarely missed a day of work. He trained his chefs to mimic his palate and learned how to cook with his other senses. As Kokonas was able to attest: The food was never better. Five months later, Grant was declared cancer-free, and just a few months following, he received the James Beard Foundation Outstanding Chef in America Award ...
http://www.tatteredcover.com/book/9781592406012
From Genes, Marriage and Money to Nurture: Redefining Fatherhood by Nancy E. Dowd :: SSRNFrom Genes, Marriage and Money to Nurture: Redefining Fatherhood by Nancy E. Dowd :: SSRN
Genes should not define fatherhood. This is wrong for men, and wrong for children. Genes define identity, but that link should be separated from the obligations
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2682762
Redefining the Shape of Sound: Resonado Introduces Flat Core Speaker Technology at CES 2020 | audioXpressRedefining the Shape of Sound: Resonado Introduces Flat Core Speaker Technology at CES 2020 | audioXpress
Resonado, a South Bend, Indiana company founded at the University of Notre Dame, has a new take on electrodynamic speaker topology. The company developed a reconfigured speaker with a planar voice coil mounted perpendicularly to its flat
https://audioxpress.com/news/redefining-the-shape-of-sound-resonado-introduces-flat-core-speaker-technology-at-ces-2020
Redefining Peer Review - Editor Resigns « the Air VentRedefining Peer Review - Editor Resigns « the Air Vent
UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
https://noconsensus.wordpress.com/2011/09/02/345-4/?replytocom=54642
Korean startup redefining regenerative healthcare - Asia TimesKorean startup redefining regenerative healthcare - Asia Times
SEOUL - It may be the most gruesome disease you have never heard of. Somewhere in the world, every 1-2 seconds, a diabetic gets a foot ulcer. Half of
https://asiatimes.com/2021/01/korean-startup-redefining-regenerative-healthcare/
Schizophrenia Archives - Redefining PsychosisSchizophrenia Archives - Redefining Psychosis
Tim Dreby has been featured on several podcasts including Madness Radio and Psychosis Summit. He has been published on blogs like Mad in America, The Mighty, The Better Because Project, Stigma Fighters, and Asylum Magazine.. ...
https://timdreby.com/tag/schizophrenia/
Redefining cardiomyopathies: the role of cardiovascular magnetic resonance imaging - Wellcome Centre for Human GeneticsRedefining cardiomyopathies: the role of cardiovascular magnetic resonance imaging - Wellcome Centre for Human Genetics
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.well.ox.ac.uk/publications/105380/
Redefining Peer Review - Editor Resigns « the Air VentRedefining Peer Review - Editor Resigns « the Air Vent
UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
https://noconsensus.wordpress.com/2011/09/02/345-4/?replytocom=54652
Redefining health care | Philstar.comRedefining health care | Philstar.com
Top executives of Maxicare Healthcare Corp. gathered at SM City Clark to inaugurate the first Maxicare Primary Care Center in Pampanga.
https://www.philstar.com/other-sections/newsmakers/2020/01/07/1982558/redefining-health-care
Dietary Fat and the Human Brain: Redefining Food for Thought | HuffPost LifeDietary Fat and the Human Brain: Redefining Food for Thought | HuffPost Life
As our kids return to school, its a perfect opportunity to reflect on the human brain doing what it does uniquely well in all the known animal kingdom:...
https://www.huffpost.com/entry/dietary-fat-and-the-human_b_8089586
Aesthetica Magazine - See Yourself Sensing: Redefining Human PerceptionAesthetica Magazine - See Yourself Sensing: Redefining Human Perception
Schwartzman has captured the present in this text. Exploring the relationship between the body, design and technology, the book is perplexing and provocative.
http://www.aestheticamagazine.com/see-yourself-sensing-redefining-human-perception/?adclick=186
Redefining the world of coffee | Avril Supermarché SantéRedefining the world of coffee | Avril Supermarché Santé
What is Café Mystiques mission? To become one of Canadas leading companies in the import, roasting and distribution of specialty grade coffees. Find out more
https://www.avril.ca/en/online-magazine/redefining-the-world-of-coffee/
Redefining folks by morphing the traditional art - Anahad Foundation - MediumRedefining folks by morphing the traditional art - Anahad Foundation - Medium
In a land where music is embedded in the ramparts of every palace, and the stones of the fort, in each nook and corner, Salim Khans music stands out for its sheer simplicity, and the rare…
https://medium.com/@anahad_ngo/redefining-folks-by-morphing-the-traditional-art-a362abaf0d1b
Aesthetica Magazine - See Yourself Sensing: Redefining Human PerceptionAesthetica Magazine - See Yourself Sensing: Redefining Human Perception
Schwartzman has captured the present in this text. Exploring the relationship between the body, design and technology, the book is perplexing and provocative.
http://www.aestheticamagazine.com/see-yourself-sensing-redefining-human-perception/?adclick=161
México Presents: Redefining Rotastenting - Transradial Rotational Ablation of an Underexpanded Stent in STEMI | tctmd.comMéxico Presents: Redefining Rotastenting - Transradial Rotational Ablation of an Underexpanded Stent in STEMI | tctmd.com
Thank you for taking the time to nominate a fellow for TCTMDs Featured Fellow section on the Fellows Forum. Nominees should be current general or interventional cardiology fellows who you have supervised or mentored and think should be recognized for a combination of their scholarship, skills, talent, and commitment to top-notch patient care. If your nominee is selected, you will be notified of our selection and alerted when the story appears on TCTMD. Please email [email protected] with any questions ...
https://www.tctmd.com/slide/mexico-presents-redefining-rotastenting-transradial-rotational-ablation-underexpanded-stent
The Human Algorithm: Redefining the Value of DataThe Human Algorithm: Redefining the Value of Data
The human algorithm is part understanding and part communication. The ability to communicate and apply insights internally and externally is the key to unlocking opportunities to earn relevance. Beyond research, beyond intelligence, the human algorithm is a function of extracting insights with intention, humanizing trends ad possibilities and working with strategists to improve and innovate everything from processes to products to overall experiences.. The idea of the human algorithm is to serve as the human counterpart to the abundance of new social intelligence and listening platforms hitting the market every day. Someone has to be on the other side of data to interpret it beyond routine. Someone has to redefine the typical buckets where data is poured. And someone has to redefine the value of data to save important findings from a slow and eventual death by three-ring binders rich with direction and meaning.. One place where the human algorithm can have an immediate impact is in social media ...
http://www.briansolis.com/2012/12/the-human-algorithm-redefining-the-value-of-data/
How artificial intelligence is redefining the role of manager | World Economic ForumHow artificial intelligence is redefining the role of manager | World Economic Forum
Employees are increasingly happy to receive orders from AI or bots - who are freeing up managers to pay better attention to their employees.
https://www.weforum.org/agenda/2019/11/how-artificial-intelligence-is-redefining-the-role-of-manager/
Redefining Self CareRedefining Self Care
Self-care is often described as getting your nails done, drinking a glass of wine and chilling out. Ive seen a lot of posts on how to exercise self-care that mimic these things and I even wrote one myself in my Pretty Girl In College days. One thing Ive learned since then is that is not the only type of self-care the
https://www.abriae.com/post/redefining-self-care-1
World Congress of Internal Medicine - Cape Town - Centre of Research Excellence in Redefining Antimicrobial Use to Reduce...World Congress of Internal Medicine - Cape Town - Centre of Research Excellence in Redefining Antimicrobial Use to Reduce...
Prof Lipman recently presented at the 34th Congress of Internal Medicine in Cape Town, South Africa held 18-21 October 2018.. The meeting aimed at medical specialties such as Cardiology, Pulmonology and Critical Care but also provided an excellent academic programme for the general physician.. Prof Lipman was part of an exciting faculty drawn from experts across the international community.. In the video above Prof Lipman discusses therapeutic drug monitoring of β-lactam antibiotics and his optimistic outlook on the global probem of antimicrobial resistance.. ...
https://cre-reduce.centre.uq.edu.au/article/2018/11/cape-town-world-congress-internal-medicine
Abigail with attitude: Jenkins Gulag-esque approach to redefining Barclays | EuromoneyAbigail with attitude: Jenkins Gulag-esque approach to redefining Barclays | Euromoney
Trying to change cultures within banking institutions is never easy, which is why Barclays new chief executive is taking a hard and seemingly Soviet-era approach at the UK bank. The message is clear: Barclays would now like to be seen as a stodgy commercial bank run by a proselytizing Brit.
https://www.euromoney.com/article/b12kjssdr57p5y/abigail-with-attitude-jenkins39-gulagesque-approach-to-redefining-barclays
Bentley adds three product firsts to OpenPlant, redefining comprehensiveness in plant creation software | Environmental XPRTBentley adds three product firsts to OpenPlant, redefining comprehensiveness in plant creation software | Environmental XPRT
Bentley Systems, Incorporated, the leading company dedicated to providing comprehensive software solutions for the infrastructure that sustains our world, ...
https://www.environmental-expert.com/news/bentley-adds-three-product-firsts-to-openplant-redefining-comprehensiveness-in-plant-creation-softwa-189322
Redefining Student Success in a Digital Ecosystem -- Campus TechnologyRedefining Student Success in a Digital Ecosystem -- Campus Technology
Retention and graduation rates may be good indicators of a college or universitys success, but they have little to do with students personal development as connected learners and contributors to the digital commons.
https://campustechnology.com/articles/2016/04/11/redefining-student-success-in-a-digital-ecosystem.aspx
PALE ALE Archives | BOOZE FREE - Redefining DrinkingPALE ALE Archives | BOOZE FREE - Redefining Drinking
We use cookies to hold user preferences, store information for the Basket, and provide anonymised tracking data for analysis tools, such as Google Analytics. By continuing to use this website you confirm that you accept our cookie usage.. You can find out more at any time by viewing our Privacy Policy which has a link to our Use of Cookies page.. ...
https://www.boozefree.uk/product-tag/pale-ale/
Redefining NeverRedefining Never
CMS would have you believe that this is about quality and patient safety. Who can argue with those laudable goals? They are so revered as to be sacred, and with good reason. But dont be fooled. This is cost containment masquerading as quality. As we start to see more and more of these unpreventable never events proliferating, and more and more payors signing on to the concept of not paying for errors you will see that this is really about reducing the total amount that the big payors spend on the care of sick patients, and shifting the risk of caring for the critically ill onto care providers. It is also informative that CMS is focusing on payments to hospitals, which are much more expensive than the payments to physicians, despite the fact that physicians would theoretically be just as sensitive to payment reductions and are in a position to more directly improve the quality of care ...
https://allbleedingstops.blogspot.com/2008/04/redefining-never.html
Redefining solids filtration in process water | Opinion | Heating and Ventilation NewsRedefining solids filtration in process water | Opinion | Heating and Ventilation News
Engineers, manufacturers, utilities, public and private enterprise, commerce - in fact, anyone that uses water for temperature control - are, for the most part, quite comfortable in the belief that they are operating an effective and safe water system. But how safe are they really?
https://www.hvnplus.co.uk/opinion/redefining-solids-filtration-in-process-water/8687818.article
How automation and AI are redefining workHow automation and AI are redefining work
In this episode of the Brookings Cafeteria podcast, Mark Muro discusses his new report on automation and the workforce. Also, Molly Reynolds explains what is happening in Congress.
https://www.brookings.edu/podcast-episode/how-automation-and-ai-are-redefining-work/
Jimmy Carter, Cancer & Redefining the New Old Age - Big ThinkJimmy Carter, Cancer & Redefining the New Old Age - Big Think
Carter said he was surprisingly at ease when he received his diagnosis. Perhaps part of that serenity comes from the knowledge of the good works he has done in his life.
https://bigthink.com/disruptive-demographics/jimmy-carter-cancer-redefining-the-new-old-age
Beyond Reach: Redefining Online Advertising Waste and Revealing its Value | ANA Topics | ANABeyond Reach: Redefining Online Advertising Waste and Revealing its Value | ANA Topics | ANA
Charles Buchwalter, SVP, Nielsen Online, and Jon Gibbs, SVP, Nielsen Analytics and Insight, were joined by Jeffrey Holecko, media manager, Kimberly-Clark, to discuss the keys to defining a successful online ad campaign.
http://www.ana.net/miccontent/show/id/s-tv-oct11-nielsen/topic/digitalmarketing
Volume X: Selected Facebook Updates And Tweets Of Chandran K C On Scientific Homeopathy | REDEFINING HOMEOPATHYVolume X: Selected Facebook Updates And Tweets Of Chandran K C On Scientific Homeopathy | REDEFINING HOMEOPATHY
When I say homeopathic drug, I mean ONLY potencies 12c or above, which contain only molecular imprints that act by a homeopathic mechanism of biological action by binding to the specific pathogenic molecules. I do not consider molecular forms (crude and below 12c) of drugs as homeopathic - whether they are single or mixed. They…
https://redefininghomeopathy.com/2015/12/11/volume-x-selected-facebook-updates-and-tweets-of-chandran-k-c-on-scientific-homeopathy/
Redefining Pain - CountercurrentsRedefining Pain - Countercurrents
The word pain literally means a highly unpleasant physical sensation caused by illness or injury. If so, what I experienced during the first 3 months of my treatment was something much more than unpleasant or physical. It was a constant affliction that pervaded from the site of injury ie.my right foot upwards to my head. The most agonising moments were when the pain spread stealthily to your mind causing a numbness and freeze hitherto unknown to me in all the 52 years of my life.Being a person prone to resist and disagree with any kind of discomfort this phase of my life taught me many a hard lesson. It set me wondering if one really had to go through such hard times to realise some simple and obviously handy attributes that make life easier and liveable.But I was chosen by some force to know it the hardest way.. My first experience with intense pain was in the naturopathy centre where I took refuge from the merciless and invasive world of modern medicine that I had such unreasonable ...
https://countercurrents.org/2017/10/27/redefining-pain/
Redefining bioabsorbable DES with MiStent: drug elution beyond polymer presenceRedefining bioabsorbable DES with MiStent: drug elution beyond polymer presence
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https://www.pcronline.com/Cases-resources-images/Resources/Course-videos-slides/2015/Redefining-bioabsorbable-DES-with-MiStent-drug-elution-beyond-polymer-presence
4 Moves To Prevent Low Back Pain | Redefining Strength4 Moves To Prevent Low Back Pain | Redefining Strength
4 Moves To Prevent Low Back Pain - Use these 4 activation exercises to get your abs and glutes working and prevent low back pain!
https://redefiningstrength.com/4-moves-to-prevent-low-back-pain/
Redefining fatal child neglect | Child Family Community AustraliaRedefining fatal child neglect | Child Family Community Australia
|div class=field field-name-body field-type-text-with-summary field-label-hidden||div class=field-items||div class=field-item even property=content:encoded||p|This paper outlines a theoretical framework to underpin the definitions of fatal child neglect and provides an ecological perspective on prevention.|/p| |/div||/div||/div|
https://aifs.gov.au/cfca/publications/redefining-fatal-child-neglect
Malaysia: Ministry bans Islamic state debate in media | Women Reclaiming and Redefining CulturesMalaysia: Ministry bans Islamic state debate in media | Women Reclaiming and Redefining Cultures
Press Statement from the Malaysian Bar Council: Malaysia is a secular State. The statement made by the Deputy Prime Minister in this 50th year of Merdeka that Malaysia has never been a secular state is startling as it ignores the undisputed constitutional history of the country as well as the social contract by which the multi racial and multi-religious people of this nation came together. The Federal Constitution was a carefully thought out, carefully negotiated document that evolved after much debate and discussion. Some historical context is necessary. In 1956, Tunku Abdul Rahman had headed a Merdeka Mission to London to negotiate for independence. The negotiations were conducted by 4 representatives of the Malay Rulers, 4 representatives of the then Alliance Government and representatives of the British Government. The Reid Commission was then appointed to draft a constitution for independent Malaya. The Reid Commission held 118 meetings in Malaya. It met a wide cross-section of people ...
http://www.wluml.org/node/3884
Redefining Cancer: The Breast-Condition Puzzle - NYTimes.comRedefining Cancer: The Breast-Condition Puzzle - NYTimes.com
To the Editor:. As breast cancer continues to pose a major health risk for women, we can ill afford to engage in semantic arguments about what we should call cancer.. A simple name change for ductal carcinoma in situ of the breast should not unravel decades of clinical trial work dealing with its management. Simply put, we cannot predict which lesions will progress (the majority) versus those that are unlikely to progress (a small subset, primarily in older patients).. What the medical community needs is better class prediction based upon a functional understanding of the individual genomic mechanisms involved. Downgrading all ductal carcinoma in situ to indolent lesions of epithelial origin or pre-cancer makes us fear that insurers will stop paying for lifesaving treatments like radiation therapy, anti-estrogen therapy or, on occasion, mastectomies.. It is the physicians responsibility to chart a critical course of treatment for his patients based on each womans circumstances. Our best chance ...
https://mobile.nytimes.com/2013/08/05/opinion/redefining-cancer-the-breast-condition-puzzle.html
Whiplash associated disorders: redefining whiplash and its management by the Quebec Task Force. A critical...Whiplash associated disorders: redefining whiplash and its management by the Quebec Task Force. A critical...
The validity of the conclusions and recommendations of the Quebec Task Force regarding the natural course and epidemiology of whiplash injuries is questionable. This lack of validity stems from the presence of bias, the use of unconventional terminology, and conclusions that are not concurrent with …
https://pubmed.ncbi.nlm.nih.gov/9589544/
REDEFINING HOMEOPATHYREDEFINING HOMEOPATHY
Any substance use as DRUGS are composed of one or more types of simple or complex molecules having their own individual structures and chemical properties. When the drugs enter the living bodies, it is those INDIVIDUAL chemical molecules that act up on different biological target molecules according to their specific affinities, producing conformational changes in…
https://redefininghomeopathy.com/2015/12/11/1535/
Entry Level Clinical Nutrition™-Redefining What We Do In A New Age Of Increased Sickness & Increased Scarcity - Part III - Moss...Entry Level Clinical Nutrition™-Redefining What We Do In A New Age Of Increased Sickness & Increased Scarcity - Part III - Moss...
The Clinical And Metabolic Foundation: The Acute Phase Response - Definition However beautiful the strategy, you should occasionally look at the results -Winston Churchill At the time I first became involved with clinical nutrition, which was 1979 in my dental practice, it was very much in vogue for authors and lecturers in this field to…
https://mnlibrary.blog/2010/02/01/entry-level-clinical-nutrition-redefining-what-we-do-in-a-new-age-of-increased-sickness-increased-scarcity-part-iii/
Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic...Redefining Androgen Receptor Function: Clinical Implications in Understanding Prostate Cancer Progression and Therapeutic...
The current description of the function of the human androgen receptor (AR), as a transcription factor directing androgen responsive gene expression, is limited in scope and thus is unable to account for the varied cellular and physiological transformation observed in the development and progression of prostate cancer (CaP). The chapter will focus on four important aspects of AR and CaP investigations: (1) a description of AR somatic mutations and the perils of AR-directed therapeutics; (2) our characterization of AR protein interactors that have imbued new functional properties for AR linked to prostatic disease; (3) review of the advances made and shortcomings of AR mouse models in describing CaP onset and progression; and (4) speculate as to the mechanisms by which new mutations can originate and initiate disease onset.
https://www.intechopen.com/books/prostate-cancer-leading-edge-diagnostic-procedures-and-treatments/redefining-androgen-receptor-function-clinical-implications-in-understanding-prostate-cancer-progres
Sandor Katz Fermenting Workshop | ReLocavore: Redefining localSandor Katz Fermenting Workshop | ReLocavore: Redefining local
On Jul 22-23 I participated in a Fermenting workshop with Sandor Katz, the author of The Art of Fermentation and Wild Fermentation. Shelburne Farms, just outside Burlington, Vermont hosted the event. If youve been to Shelburne Farms before, we were in the Coach Barn for the event. Over two days we covered the basics of…
https://relocavore.com/2014/07/27/sandor-katz-fermenting-workshop/
Redefining the Engineering Design Process With Computer-Aided Optimization - SAE InternationalRedefining the Engineering Design Process With Computer-Aided Optimization - SAE International
Since the birth of the computer age, the drive to bring products to market faster, better and cheaper has been a shared, unparalleled competitive pressure across every engineering design project, regardless of its size or purpose.While the rapid advances in computer power and technology over the past decade have ushered in such powerful technology drivers as CAD (Computer-Aided Design) and CAE (Computer-Aided Engineering), the greatest engineering design productivity bottleneck for most design projects still remains at the human level ...
http://papers.sae.org/971477/
New book: Redefining Translation and Interpretation in Cultural EvolutionNew book: Redefining Translation and Interpretation in Cultural Evolution
by Olaf Immanuel Seel (Ionian University of Corfu, Greece) Description Culture has a significant influence on the emerging trends in translation and i...
https://www.iatis.org/index.php/news/item/1564-new-book-redefining-translation-and-interpretation-in-cultural-evolution
Yellowstone, Mars, and Redefining LifeYellowstone, Mars, and Redefining Life
Yellowstones hot spring organisms broadened our understanding of life and changed the way scientists thought about the prospects for life on Mars and beyond. - Faye Flam, Philadelphia Inquirer
http://www.philly.com/philly/blogs/evolution/Yellowstone-Mars-and-the-Definition-of-Life.html
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation ConceptRedefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
Abstract Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. A more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. In this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. We describe the age-related upregulation of nuclear factor (NF)-κB signaling, cytokines/chemokines, endoplasmic reticulum (ER) stress, inflammasome, and lipid accumulation. ...
http://www.aginganddisease.org/EN/10.14336/AD.2018.0324
Redefining sustainable development - Stockholm Resilience CentreRedefining sustainable development - Stockholm Resilience Centre
Advances the understanding of complex social-ecological systems with new insights into ecosystem management practices and long-term sustainability
http://www.stockholmresilience.org/research/research-videos/2013-04-05-redefining-sustainable-development.html
Deadbeat or Deadbroke: Redefining Child Support for Poor Fathers by Solangel Maldonado :: SSRNDeadbeat or Deadbroke: Redefining Child Support for Poor Fathers by Solangel Maldonado :: SSRN
This Essay builds on prior work examining the role the law plays in fostering or discouraging nurturing relationships between fathers and children. In Beyond Ec
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=1789894
VM -- Redefining Cloning, Jun 02 ... Virtual MentorVM -- Redefining Cloning, Jun 02 ... Virtual Mentor
Media coverage, proposed legislation, and lexicons influence how the general public views and defines genetic cloning. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
http://journalofethics.ama-assn.org/2002/06/gnth1-0206.html
Redefining protest in Ethiopia: what happens to the terror narrative when Muslims call for a secular state? | openDemocracyRedefining protest in Ethiopia: what happens to the terror narrative when Muslims call for a secular state? | openDemocracy
From the periphery, Ethiopian Muslim protesters have recently turned a page in the history of the country. They have proven that demonstrations by religious groups can be peaceful, that secularism can be the aim of these groups instead of their nemesis and that a radical Islamist agenda doesn't have to be the dominant one.
https://www.opendemocracy.net/en/redefining-protest-in-ethiopia-what-happens-to-terror-narrative-when-musl/
A New View of Free Radicals | Redefining MeditationA New View of Free Radicals | Redefining Meditation
Sounds like we are gonna get a little crazy with this post, hmmm? Revolution in the streets!? Only in your minds, my friends. Just like my last meditation about Yoga, this time around I got far more than I was expecting. I am loving the flow of information and the unexpected direction of it all.…
https://redefiningmeditation.wordpress.com/2016/02/13/a-new-view-of-free-radicals/
Redefining Dementia in DenmarkRedefining Dementia in Denmark
Heres a blog post I wrote today - you or someone you love suffers from memory loss, you will be interested to read this. http://www.donnathomson.com/2012/11/redefining-dementia-lets-all-go-to.html PS: I usually post in Child Neuro, but I was inspired to write this today.
http://braintalkcommunities.org/showthread.php/2836-Redefining-Dementia-in-Denmark?p=19702
Tifluadom - Wikipedias Tifluadom as translated by GramTransTifluadom - Wikipedias Tifluadom as translated by GramTrans
konfirmi) Tifluadom [1] estas benzodiazepin derivaĵo kun nekutima agadprofilo. Male al la plej multaj benzodiazepinoj, tifluadom havas neniun agadon ĉe la GABAA receptoro, sed anstataŭe estas selektema agonisto por la κ-opioid receptoro. [2] En konformo, ĝi havas potencan kontraŭdolorilon [3] kaj urinigaj [4] efikoj en bestoj, kaj ankaŭ havas sedativajn efikojn kaj stimulas apetiton.. Dum tifluadom havas plurajn efikojn kiuj eble havos eblajn uzojn en medicino kiel ekzemple analgezio kaj apetitstimulo, κ-opioid agonistoj tendencas produkti nedezirindajn efikojn en homoj kiel ekzemple disforio kaj halucinoj, kaj tiel tiuj medikamentoj tendencas nur esti uzitaj en scienca esplorado. Disforaj efikoj estas similaj al tiuj viditaj kiam uzado de aliaj κ-opioid receptoragonistoj kiel pentazocino kaj salvinorin A.. ...
https://epo.wikitrans.net/Tifluadom
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl formate,68683-22-7 - LookChemical.com3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl formate,68683-22-7 - LookChemical.com
3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl formate,68683-22-7 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Search for free and find new suppliers for chemical products, pharmaceuticals and APIs.
http://www.lookchemical.com/3a_4_5_6_7_7a-hexahydro-4_7-methano-1H-indenyl_formate/68683-22-7.html
3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione - Manufacturer,Supplier & Exporter3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione - Manufacturer,Supplier & Exporter
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Congrats to our Gerber Travel Trouble competition winners! - Matador NetworkCongrats to our Gerber Travel Trouble competition winners! - Matador Network
Matador is a travel and lifestyle brand redefining travel media with cutting edge adventure stories, photojournalism, and social commentary.
https://matadornetwork.com/pulse/congrats-to-our-gerber-travel-trouble-competition-winners/
5 ways travel can help with depression - Matador Network5 ways travel can help with depression - Matador Network
Matador is a travel and lifestyle brand redefining travel media with cutting edge adventure stories, photojournalism, and social commentary.
https://matadornetwork.com/life/5-ways-travel-can-help-depression/
Neuroscience at Davos - NeurophilosophyNeuroscience at Davos - Neurophilosophy
Technology blogger Robert Scoble attended the World Economic Forum at Davos, and made quite a few video recordings of the conversations he had with various people while he was there, which he has uploaded to Qik. In this film, Scoble talks to the Brazilian neuroscientist Miguel Nicolelis, who discussed his recent experiments in which a monkey with a brain-computer interface implanted into its motor cortex controlled the movements of a robot that was located more than 7,000 miles away. Nicolelis presented his results during a session called Redefining the limits of the human body, which included Emory Brown, a computational neuroscientist at MIT, and Hugh Herr, the director of MITs Biomechatronics Group. In this 14-minute film, Scoble talks to Brown, Herr, and Cynthia Breazeal, who heads the Personal Robotics Group (also at MIT). The World Economic Forum YouTube channel includes videos of talks given by British Prime Minister Gordon Brown, Afghani President Hamid Karzai, U.S. Secretary of State ...
http://scienceblogs.com/neurophilosophy/2008/02/04/neuroscience-at-davos/
Things To Do On A Vacation to Albuquerque NMThings To Do On A Vacation to Albuquerque NM
Primary Goal in Life: To be the 3rd nicest person in the Universe. I achieve this goal by constantly redefining the word nicest, which is currently 8735 words long in all its nuances and handling special incidents such as road rage and being attacked by wildlife. I wake up every day looking forward to the next friend that I will make, the piece of art that I will create, and the culinary discovery that makes my taste buds tumble. I not only have favorite pieces of music, I have favorite notes within those pieces ...
http://esbboston.blogspot.com/2013/05/things-to-do-on-vacation-to-albuquerque.html
Emerging Role of Sensory Perception in Aging and Metabolism. - Helen Wills Neuroscience InstituteEmerging Role of Sensory Perception in Aging and Metabolism. - Helen Wills Neuroscience Institute
Sensory perception comprises gustatory (taste) and olfactory (smell) modalities as well as somatosensory (pain, heat, and tactile mechanosensory) inputs, which are detected by a multitude of sensory receptors. These sensory receptors are contained in specialized ciliated neurons where they detect changes in environmental conditions and participate in behavioral decisions ranging from food choice to avoiding harmful conditions, thus insuring basic survival in metazoans. Recent genetic studies, however, indicate that sensory perception plays additional physiological functions, notably influencing energy homeostatic processes and longevity through neuronal circuits originating from sensory tissues. Here we review how these findings are redefining metabolic signaling and establish a prominent role of sensory neuroendocrine processes in controlling health span and lifespan, with a goal of translating this knowledge towards managing age-associated diseases. PMID: 27067041 [PubMed - indexed for ...
http://neuroscience.berkeley.edu/publications/emerging-role-of-sensory-perception-in-aging-and-metabolism/
The Measurement of Multidimensional PovertyThe Measurement of Multidimensional Poverty
Many authors have insisted on the necessity of defining poverty as a multi-dimensional concept rather than relying on income or consumption expenditures per capita. Yet, not much has actually been done to include the various dimensions of deprivation into the practical definition and measurement of poverty. Existing attempts along that direction consist of aggregating various attributes into a single index through some arbitrary function and defining a poverty line and associated poverty measures on the basis of that index. All this is merely redefining the more general concept of poverty, which then essentially remains a uni-dimensional concept. On the contrary, the present paper suggests that the only way to truly take into account the multi-dimensionality of poverty is to specify a poverty line for each dimension of poverty and to consider that a person is poor if he/she falls below at least one of these various lines. The paper then explores ways to combine these various poverty lines and associated
https://ideas.repec.org/p/del/abcdef/98-12.html
chronic back pain Archives - Irene Lyonchronic back pain Archives - Irene Lyon
Im here to bring a ginormous spotlight to an area of health and healing thats being overlooked: unresolved and untreated trauma (of all kinds!).. Before you say, I wasnt traumatize, please, please stick around because we, the scientific and clinical practice community, are finally redefining what a traumatic experience and adversity really is and it is not what most people think! I am here to give everybody access to education that is NOT dumbed down and assumes the reader wants the truth - even if it means getting into the nitty-gritty and feeling some feels. This means my articles (and videos that often accompany them) are more on the in-depth side and require you to think a bit more. In some cases a lot more. I hope you take some time to sink your curiosity into all that is on this page.. Much Love. ...
https://irenelyon.com/tag/chronic-back-pain/
The Measurement of Multidimensional PovertyThe Measurement of Multidimensional Poverty
Downloadable (with restrictions)! Many authors have insisted on the necessity of defining poverty as a multi-dimensional concept rather than relying on income or consumption expenditures per capita. Yet, not much has actually been done to include the various dimensions of deprivation into the practical definition and measurement of poverty. Existing attempts along that direction consist of aggregating various attributes into a single index through some arbitrary function and defining a poverty line and associated poverty measures on the basis of that index. All this is merely redefining the more general concept of poverty, which then essentially remains a uni-dimensional concept. On the contrary, the present paper suggests that the only way to truly take into account the multi-dimensionality of poverty is to specify a poverty line for each dimension of poverty and to consider that a person is poor if he/she falls below at least one of these various lines. The paper then explores ways to combine these
https://ideas.repec.org/a/kap/jecinq/v1y2003i1p25-49.html
Natural Clay Mask™ | Blemish Solutions | Medik8 UKNatural Clay Mask™ | Blemish Solutions | Medik8 UK
Meet the mask thats redefining the face of deep-cleansing: Natural Clay Mask draws out impurities while nourishing skin to leave you with the purest, clearest complexion.
https://www.medik8.com/natural-clay-mask.html
Female Iguanas: Are they more difficult to tame?Female Iguanas: Are they more difficult to tame?
Why dont female iguanas get as tame as males?. Why are females always so cranky?. Ive been thinking a bit about adult female igs and why they are so often reported as being bitchy and unfriendly. Having watched the three big adult females around here, as they met and settled in with each other (and, in the process, redefining the existing organizational hierarchy) and having dealt with an assortment of males of various sizes temperaments, it comes to mind that the females are not bitchy or unfriendly - theyre just used to dealing with macho (territorial, posturing, periodically lusty) males.. Where males defend and work to extend territory and try to mate with whatever female walks through or in close proximity to the area, females just cant be bothered with that nonsense, literally and figuratively brushing the males off if they are not receptive to their attentions. It is the females here who get the food first. And first of all females is the new alpha female, Iguanita, who supplanted the ...
http://www.anapsid.org/iguana/femaleigs.html
New guidelines redefine what classes as high blood pressureNew guidelines redefine what classes as high blood pressure
New guidelines have been released redefining the parameters for high blood pressure so that the condition can be treated earlier.
https://www.news-medical.net/news/20171114/New-guidelines-redefine-what-classes-as-high-blood-pressure.aspx
New Adult Nonfiction for July | Josephine Community LibrariesNew Adult Nonfiction for July | Josephine Community Libraries
a chord with every woman. This seven book series is among the best reviewed humor books published today and has been compared to the late greats, Erma Bombeck and Nora Ephron.. American Fire: Love, Arson, and Life in a Vanishing Land by Monica Hesse. A breathtaking feat of reportage, American Fire combines procedural with love story, redefining American tragedy for our time.. Fall Down 7 Times Get Up 8: A Young Mans Voice from the Silence of Autism by Naoki Higashida. Naoki Higashida wrote The Reason I Jump as a 13-year-old boy. Now, he shares his thoughts and experiences as a 24-year old young man with severe autism. In short, powerful chapters, he explores education, identity, family, society and personal growth. He also allows readers to experience profound moments we take for granted, like the thought-steps necessary for him to register that its raining outside.. Why?: What Makes Us Curious by Mario Livio. Experiments demonstrate that people are more distracted when they overhear a ...
https://josephinelibrary.org/2017/07/10/new-adult-nonfiction-for-july/
Project Baseline by Verily: Taking Clinical Trials into the 21st Century | Discover Otsuka | Otsuka in the U.S.Project Baseline by Verily: Taking Clinical Trials into the 21st Century | Discover Otsuka | Otsuka in the U.S.
Otsuka is at the forefront of redefining the clinical trial process to improve accessibility and obtain more precise and targeted data more quickly. If we can get results and seek approvals sooner, we will ultimately put therapies into the hands of physicians and their patients earlier. Were excited to be working with Verily, a sister company to Google, to develop digitally innovative, patient-centered clinical research programs using Verilys Project Baseline.
https://www.otsuka-us.com/discover/only-otsuka-blog/june-2019-blog
Search | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramSearch | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
Exposure ha creado una biblioteca educacional en la red que se llama FRAME (Faces Redefining the Art of Medical Education) y que presenta información médica de forma innovadora, utilizando la fotografía, el, . ¿Qué es la herencia recesiva ligada al cromosoma X?. Rare Commons.Hospital Sant Joan de Déu de Barcelona. 2016; https://www.rarecommons.org/es/actualidad/es-herencia-recesiva-ligada-cromosoma-x. ¿ ... ...
https://rarediseases.info.nih.gov/search?Keyword=list%20of%20rare%20diseases-r&page=605&Filters=contentType%3Ddisease
Download For Self Examination ; Judge For Yourself!Download For Self Examination ; Judge For Yourself!
federal rights give many Contributions; glucosinolate download For self examination ;, cultural Redefining of assays and woman genes with Prime Video and cultivated more related prices. There requires a firm going this format at the someone. reduce more about Amazon Prime.
http://mutter-kind-bindungsanalyse.de/lager/pdf/download-For-self-examination-%3B-Judge-for-yourself%21.php
Apples Tablet Could Be Print Industrys Lifeboat | WIREDApples Tablet Could Be Print Industrys Lifeboat | WIRED
The more you think about it, the more obvious it is that an Apple tablet would specialize in reviving dead-tree media (i.e., newspapers, magazines and books). All the rumors suggest the device would be a larger iPod Touch/iPhone with a 10-inch screen. Previously Wired.com argued that redefining print would be a logical purpose for a […]
https://www.wired.com/2009/09/tablet-print/
AzocineAzocine
These include cyclazocine, pentazocine, and phenazocine. The fully saturated analog of azocine is azocane. Azocine rings are ...
https://en.wikipedia.org/wiki/Azocine
PentazocinePentazocine
Cyclazocine (hallucinogenic) Volazocine Stitzel RE (2004). Modern pharmacology with clinical applications (6th ed.). ...
https://en.wikipedia.org/wiki/Pentazocine
VolazocineVolazocine
Benzomorphan ketazocine cyclazocine World Health Organization (2004). "The use of stems in the selection of International ...
https://en.wikipedia.org/wiki/Volazocine
8-Carboxamidocyclazocine8-Carboxamidocyclazocine
Similarly to cyclazocine, 8-CAC acts as an agonist at both the μ and κ opioid receptors, but has a much longer duration of ... Unexpectedly it was discovered that the phenolic hydroxyl group of cyclazocine could be replaced by a carboxamido group with ... 8-Carboxamidocyclazocine (8-CAC) is an opioid analgesic drug related to cyclazocine, discovered by medicinal chemist Mark P. ... Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine". Bioorganic & Medicinal Chemistry Letters. ...
https://en.wikipedia.org/wiki/8-Carboxamidocyclazocine
HallucinogenHallucinogen
... cyclazocine, and dextrorphan in the pigeon". Psychopharmacology. 73 (3): 286-91. doi:10.1007/BF00422419. hdl:2027.42/46423. ...
https://en.wikipedia.org/wiki/Hallucinogen
CiklazocinCiklazocin
"Cyclazocine and Methadone in Narcotic Addiction". http://jama.ama-assn.org/content/202/3/191.full.pdf. ... "Cyclazocine revisited - Neurochemical Research" 21 (11). pp. 1369-1373. doi:10.1007/BF02532378 ...
https://sh.wikipedia.org/wiki/Ciklazocin
PhenazocinePhenazocine
It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for ...
https://en.wikipedia.org/wiki/Phenazocine
HallucinogenHallucinogen
... cyclazocine, and dextrorphan in the pigeon". Psychopharmacology. 73 (3): 286-91. doi:10.1007/BF00422419. PMID 6787651.. ...
https://en.m.wikipedia.org/wiki/Hallucinogen
CiprefadolCiprefadol
... is an opioid analgesic that is an isoquinoline derivative most closely related to cyclazocine and picenadol, with a ...
https://en.wikipedia.org/wiki/Ciprefadol
HallucinationHallucination
Three opioids, Cyclazocine (a benzormorphan opioid/pentazocine relative) and two levorphanol-related morphinan opioids, ...
https://en.wikipedia.org/wiki/Hallucination
AlazocineAlazocine
Subsequently, other benzomorphans, such as pentazocine (an N-dimethylallylbenzomorphan), cyclazocine (an N- ...
https://en.wikipedia.org/wiki/Alazocine
C18H25NOC18H25NO
The molecular formula C18H25NO may refer to: Aminoestradiol Cyclazocine Methorphans Dextromethorphan Levomethorphan ...
https://en.wikipedia.org/wiki/C18H25NO
Sigma-1 receptorSigma-1 receptor
It was found to have affinity for the (+)-stereoisomers of several benzomorphans (e.g., (+)-pentazocine and (+)-cyclazocine), ...
https://en.wikipedia.org/wiki/Sigma-1_receptor
List of opioidsList of opioids
Cogazocine Cyclazocine Dezocine Eptazocine Etazocine [31][permanent dead link] Ethylketazocine [32] Fedotozine [33] Fluorophen ... 6β-Naltrexol 6β-Naltrexol-d4 Alvimopan AT-076 Binaltorphimine BU09059 Buprenorphine Chlornaltrexamine Clocinnamox Cyclazocine ...
https://en.wikipedia.org/wiki/List_of_opioids
Pharmaco-electroencephalographyPharmaco-electroencephalography
In testing narcotic antagonists (naloxone, cyclazocine) and opioid substitutes (methadone, levomethadyl) in the treatment of ...
https://en.wikipedia.org/wiki/Pharmaco-electroencephalography
Controlled Drugs and Substances ActControlled Drugs and Substances Act
Cyclazocine (1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(cyclopropylmethyl)-2,6-methano-3-benzazocin-8-ol) and its salts Ampromides ...
https://en.wikipedia.org/wiki/Controlled_Drugs_and_Substances_Act
Κ-opioid receptorΚ-opioid receptor
Benzomorphans Alazocine- partial agonist Bremazocine - highly selective 8-Carboxamidocyclazocine Cyclazocine - partial agonist ...
https://en.wikipedia.org/wiki/Κ-opioid_receptor
BenzomorphanBenzomorphan
9-DEHB 8-CAC Alazocine Anazocine Bremazocine Butinazocine Carbazocine Cogazocine Cyclazocine Dezocine Eptazocine Etazocine ...
https://en.wikipedia.org/wiki/Benzomorphan
List of MeSH codes (D03)List of MeSH codes (D03)
... cyclazocine MeSH D03.383.113.367.350 - ethylketocyclazocine MeSH D03.383.113.767 - oxazocines MeSH D03.383.113.767.500 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
NaltrexoneNaltrexone
The drug showed advantages over earlier opioid antagonists such as cyclazocine, nalorphine, and naloxone, including its oral ...
https://en.wikipedia.org/wiki/Naltrexone
MetazocineMetazocine
Phenazocine Pentazocine Cyclazocine Org 6582, a functional MAT inhibitor that is otherwise analogous in structure to the parent ...
https://en.wikipedia.org/wiki/Metazocine
List of drugs: Cp-CzList of drugs: Cp-Cz
... cyclazocine (INN) cyclazodone (INN) Cyclessa cyclexanone (INN) cycliramine (INN) cyclizine (INN) cyclobarbital (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Cp–Cz
CyclazocineCyclazocine
... is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs ... Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting ... Freedman, A. M.; Fink, M.; Sharoff, R.; Zaks, A. (1967). "Cyclazocine and Methadone in Narcotic Addiction". The Journal of the ... Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and ...
https://en.wikipedia.org/wiki/Cyclazocine
Papaver somniferumPapaver somniferum
It is increasingly incorrect to call Papaver somniferum the opium poppy, as many varieties do not produce a significant amount of opium. At least one produces no latex at all. That variety, therefore, also cannot be used to create codeine and other drugs from other alkaloids present in Papaver somniferum latex. This breeding has been done for two purposes. The first is to produce ornamental varieties that cannot be used for home or small-scale opium production, such as one called Danish Flag. Danish Flag and other examples of these cultivars are widely available for consumer purchase, unlike varieties that produce opium. The second is to produce cultivars that can only be used to produce other alkaloids. These are grown commercially for the pharmaceutical industry, as are varieties that are bred for high opium production. Varieties that produce large amounts of opium have been bred for the pharmaceutical industry and are not available for consumers to purchase as seed. The rapidly decreasing ...
https://en.wikipedia.org/wiki/Papaver_somniferum
LamotrigineLamotrigine
Cyclazocine. *Dehydroepiandrosterone (DHEA) (prasterone). *Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate). * ...
https://en.wikipedia.org/wiki/Lamotrigine
CaptodiameCaptodiame
Cyclazocine. *Dehydroepiandrosterone (DHEA) (prasterone). *Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate). * ...
https://en.wikipedia.org/wiki/Captodiame
ErgolineErgoline
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
https://en.wikipedia.org/wiki/Ergoline
7-Hydroxymitragynine7-Hydroxymitragynine
... is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as Kratom. In mice, it is orally active and has analgesic effects.[2] 7-Hydroxymitragynine is an agonist at the μ-opioid receptor[3] with a potency, calculated using pD (2) values, that is 30-fold higher than that of mitragynine and 17-fold higher than that of morphine, respectively.[4] As a partial agonist at this receptor[5] it causes significantly milder side effects than morphine,[6] like constipation, development of tolerance and withdrawal syndrome upon abstinence.[2] In murine models, the extracted alkaloids of the Kratom plant are shown to cause an insignificant amount of drug induced respiratory depression, unlike full μ-opioid agonists.[7] The O-acetyl ester (Acetoxy), 7-acetoxymitragynine has also been reported and found to be a weak μ-opioid agonist.[8] ...
https://en.wikipedia.org/wiki/7-Hydroxymitragynine
BMY-14802BMY-14802
Cyclazocine. *Dehydroepiandrosterone (DHEA) (prasterone). *Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate). * ...
https://en.wikipedia.org/wiki/BMY-14802
EptazocineEptazocine
Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990). "[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 95 (1): 41-6. doi:10.1254/fpj.95.1_41. PMID 2154395 ...
https://en.wikipedia.org/wiki/Eptazocine
Cyclazocine - WikipediaCyclazocine - Wikipedia
Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs ... Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting ... Freedman, A. M.; Fink, M.; Sharoff, R.; Zaks, A. (1967). "Cyclazocine and Methadone in Narcotic Addiction". The Journal of the ... Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and ...
https://en.wikipedia.org/wiki/Cyclazocine
Cyclazocine - definition of cyclazocine by The Free DictionaryCyclazocine - definition of cyclazocine by The Free Dictionary
cyclazocine synonyms, cyclazocine pronunciation, cyclazocine translation, English dictionary definition of cyclazocine. n an ... cyclazocine. Also found in: Wikipedia. cyclazocine. (saɪˈklæzəˌsiːn; saɪˈklæzəsɪn) n. an opiate antagonist used to inhibit the ... Cyclazocine - definition of cyclazocine by The Free Dictionary https://www.thefreedictionary.com/cyclazocine ... cyclazocine and nalorphine) that artificially stimulate and suppress the bodys endorphin receptors and have been known to ...
https://www.thefreedictionary.com/cyclazocine
A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLinkA correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLink
Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, ... A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats. *Samuel R. Wray1. ... Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established ... Cyclazocine and LSD administration resulted in periods of response-inhibition and a subsequent enhancement of response rates. ...
https://link.springer.com/article/10.1007%2FBF00421916
Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro...Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro...
Cyclazocine blocked responses to iontophoretically applied NMA and one component of the postsynaptic response to stimulation, ... and responses to stimulation of the underlying white matter were compared and challenged with the sigma opiate cyclazocine. ... Cyclazocine blocked responses to iontophoretically applied NMA and one component of the postsynaptic response to stimulation, ... Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro ...
https://www.semanticscholar.org/paper/Selective-blockade-of-an-excitatory-synapse-in-rat-Thomson-Lodge/46e5b0ac0510f0c58c49e8cbe919ebc0e22c7ba1
Analgesic - New World EncyclopediaAnalgesic - New World Encyclopedia
Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine 4- ...
https://www.newworldencyclopedia.org/entry/Analgesic
PentazocinePentazocine
... cyclazocine; 2-Dimethylallyl-5,9-dimethyl-2-hydroxybenzomorphan; 2-(3,3-Dimethylallyl)-2,2-hydroxy-5,9-dimethyl-6,7- ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C359831&Units=SI&Mask=FFFF
Meylers Side Effects of Drugs - Elsevier Science & Technology - Literati by CredoMeyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo
This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
https://corp.credoreference.com/component/booktracker/edition/11102.html
HydromorphoneHydromorphone
Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine 4- ...
http://www.bionity.com/en/encyclopedia/Hydromorphone.html
Azocine - WikipediaAzocine - Wikipedia
These include cyclazocine, pentazocine, and phenazocine. The fully saturated analog of azocine is azocane. Azocine rings are ...
https://en.wikipedia.org/wiki/Azocine
Patent US5413996 - Targeted drug delivery via phosphonate derivatives - Google PatentsPatent US5413996 - Targeted drug delivery via phosphonate derivatives - Google Patents
... cyclazocine and phenazocine; and those of the codeine series, such as codeine, oxycodone, drocode and pholcodine. ...
http://www.google.com/patents/US5413996?dq=7751826
StateMaster - Encyclopedia: MorphineStateMaster - Encyclopedia: Morphine
Ketazocine (INN) is a cyclazocine derivative used in opioid receptor research. ... Metazocine is an opioid analgesic related to ... 5,9-DEHB • Anazocine • Bremazocine • Cogazocine • Cyclazocine • Dezocine • Eptazocine • Etazocine • Ethylketocyclazocine • ... 5-Guanidinonaltrindole • β-Funaltrexamine • Binaltorphimine • Cyclazocine • Cyclohexyl-alpha-phenethylallylamine • ... Cyclazocine is a mixed opiate agonist-antagonist. ... Diprenorphine (Revivon, M5050) is an opiate antagonist used to reverse ...
http://www.statemaster.com/encyclopedia/Morphine
STP : main GiPCRsSTP : main GiPCRs
cyclazocine or N-allylnormetazocine , morphine. SKF 10047 benzomorphans * dextrorphan (DXO). igmesine neuroleptics, ...
http://www.ufrgs.br/imunovet/molecular_immunology/stpgipcrs.html
Why methadone maintenance worksWhy methadone maintenance works
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"Cyclazocine and Methadone in Narcotic Addiction". http://jama.ama-assn.org/content/202/3/191.full.pdf. ... "Cyclazocine revisited - Neurochemical Research" 21 (11). pp. 1369-1373. doi:10.1007/BF02532378 ...
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Kleber, H. D., Kinsella, J. K., Riordan, C., Greaves, C., and Sweeney, D., 1974, The use of cyclazocine in treating narcotic ... Resnick, R. B., Fink, M., and Freedman, A. M., 1970, A cyclazocine typology in opiate dependence, Amer. J. Psychiat. 126: 1256- ... Freedman, A. M., Fink, M., Sharoff, R., and Zaks, A., 1968, Clinical studies of cyclazocine in the treatment of narcotic ... Kissin, B., Ottomanelli, G., Sang, E., and Halloran, G., 1973, Cyclazocine treatment for heroin addicts, in Proceedings of the ...
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Discussion of depressants, also known as downers. This class of drugs include alcohol, barbiturates (such as Xanax and Valium), benzodiazepines (such as Librium, Ativan & Klonopin), and most famously, cannabis.
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PentazocineNalorphineButorphanolOpiateAgonistAgonistsLong acting narcotic antOpioidRatsPsychotomimeticAddictionSigmaFinkAffinityStudyAdministrationPatients
Pentazocine9
  • Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. (wikipedia.org)
  • These include cyclazocine, pentazocine, and phenazocine. (wikipedia.org)
  • The narcotic analgesics morphine, codeine, meperidine and methadone and the narcotic antagonist analgesics cyclazocine, cyclorphan, nalorphine and pentazocine were active. (aspetjournals.org)
  • NARCAN (naloxone) is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids, including propoxyphene, methadone and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine. (rxlist.com)
  • They are distinguished from sigma2 receptors as they have high affinity and stereoselectivity for the (+)-isomers of pentazocine, SK&F 10047 and cyclazocine, and different subcellular localizations. (genecards.org)
  • f)cyclazocine, and (-)pentazocine and also for some narcoleptics such as haloperidol. (allindianpatents.com)
  • The acute administration of levorphanol, morphine, anileridine, methadone, cyclazocine and pentazocine was found to increase brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MOPEG-SO 4 ) in rats. (elsevier.com)
  • It is also useful for the treatment of opiate-induced respiratory depression, caused by certain opiate partial agonists such as butorphanol, nalbuphine, pentazocine, and cyclazocine. (drugsdetails.com)
  • 3 An extension of this theory to a three-receptor model (mu, kappa and sigma) is required to rationalize the pharmacology of the antagonists analgesics cyclazocine, pentazocine and nalorphine. (citytidy.site)
Nalorphine7
  • Further lending credence to the exorphin dysfunction hypothesis are studies using "mixed agonist/antagonists" drugs (e.g., cyclazocine and nalorphine) that artificially stimulate and suppress the body's endorphin receptors and have been known to produce profound dysphoria bordering on psychosis in patients. (thefreedictionary.com)
  • Gluten therefore, by its "molecular mimicry" of endorphins (and enkephalins) reacts with the brain's endorphin receptors in the same deleterious way as cyclazocine or nalorphine. (thefreedictionary.com)
  • Haertzen, C. A.: Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Centre Inventory (ARCI). (springer.com)
  • Both cyclazocine and nalorphine inhibit cAMP accumulation in COS-7 cells stably expressing the clone. (aspetjournals.org)
  • Morphine stimulus properties did not generalize to nalorphine or cyclazocine, which produce dissimilar subjective effects. (meta.org)
  • The stimulus properties of LSD generalized partially to cyclazocine, but not to nalorphine. (meta.org)
  • In humans cyclazocine and nalorphine produce a high incidence of psychotomimetic effects, but the subjective effects of cyclazocine are differentiable from those of LSD. (meta.org)
Butorphanol1
  • The agonist/antagonists, butorphanol and cyclazocine, when injected, behaved like kappa agonists and increased plasma corticosterone levels potently. (aspetjournals.org)
Opiate3
  • Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro study. (semanticscholar.org)
  • article{Thomson1985SelectiveBO, title={Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro study. (semanticscholar.org)
  • In isolated slices of rat cortex, intracellularly recorded responses of pyramidal neurones to N-methylaspartate (NMA) and glutamate and responses to stimulation of the underlying white matter were compared and challenged with the sigma opiate cyclazocine. (semanticscholar.org)
Agonist2
  • Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. (erowid.org)
  • Benzomorphans I-cyclorphan(3a) Mu-antagonist girlfriend agonist dextromethorphan HO HJ O Cyclazocine (2) Cheap Mastigra 100mg In UK 2033 Bremazocine o HO Fig. (obyxova.ru)
Agonists1
  • Cyclazocine, ketocyclazocine and tifluadom (kappa- agonists ) increased NA turnover but only tifluadom increased 5-HT turnover, also reducing LH levels significantly. (manchester.ac.uk)
Long acting narcotic ant1
  • Jaffe, J. H., Brill, L.: Cyclazocine, a long acting narcotic antagonist: its voluntary acceptance as a treatment modality by narcotics abusers. (springer.com)
Opioid2
  • 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine. (nih.gov)
  • Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine. (nih.gov)
Rats2
  • Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established discriminated (Sidman) avoidance performance in rats. (springer.com)
  • The effects of cyclazocine and LSD in rats may be mediated through similar mechanisms. (springer.com)
Psychotomimetic1
  • Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting treatment of narcotic addiction was severely hampered by the drug's psychotomimetic, dysphoric, and hallucinatory effects. (wikipedia.org)
Addiction1
  • The most recent study of cyclazocine, reported in the International Journal of the Addiction, 3 in 1971, indicates that of 186 addicts offered cyclazocine, 33 accepted, of whom 11 were believed to be abstinent twenty months later. (druglibrary.org)
Sigma1
  • D-EKC and D-cyclazocine, which bind to sigma sites, had no effect on corticosterone. (aspetjournals.org)
Fink1
  • Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and colleagues (1970). (wikipedia.org)
Affinity1
  • Replacement of the phenolic hydroxyl group in non-peptide opiates with the −CONH 2 group had previously been shown to result in compounds retaining high μ receptor binding affinity 5 , 6 and introduction of a (4'-phenyl)-phenethyl substituent at the −CONH 2 group of 8-carboxamido-cyclazocine did not diminish μ receptor binding affinity. (pubmedcentralcanada.ca)
Study1
  • The study suggests, but does not prove, that the few patients who accept cyclazocine do significantly better than similar patients who attempt abstinence without cyclazocine. (druglibrary.org)
Administration1
  • Cyclazocine and LSD administration resulted in periods of response-inhibition and a subsequent enhancement of response rates. (springer.com)
Patients1
  • A psychiatrist who has had experience with both methadone and antagonist maintenance programs contrasts 'the relaxed, jovial atmosphere of a methadone ward,' where patients are free of the postaddiction syndrome, with 'the tension, frustration, and anxiety that characterize a cyclazocine ward. (druglibrary.org)
Pentazocine
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