Cyclazocine: An analgesic with mixed narcotic agonist-antagonist properties.Receptors, Phencyclidine: Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.Phenazocine: An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)Nalorphine: A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.Pentazocine: The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.Hydrocodone: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.Oxymorphone: An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)Oxycodone: A semisynthetic derivative of CODEINE.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Miosis: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.Codeine: An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Dextropropoxyphene: A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.Dextromoramide: An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)Etorphine: A narcotic analgesic morphinan used as a sedative in veterinary practice.Dihydromorphine: A semisynthetic analgesic used in the study of narcotic receptors.Methadyl Acetate: A narcotic analgesic with a long onset and duration of action.Egypt: A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.VirginiaMarylandRetrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Hospitals, Teaching: Hospitals engaged in educational and research programs, as well as providing medical care to the patients.Corticosterone: An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)Ethylketocyclazocine: A kappa opioid receptor agonist. The compound has analgesic action and shows positive inotropic effects on the electrically stimulated left atrium. It also affects various types of behavior in mammals such as locomotion, rearing, and grooming.Pituitary-Adrenal System: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.Hypothalamo-Hypophyseal System: A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.Receptors, Opioid: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.Receptors, Opioid, kappa: A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.Discrimination Learning: Learning that is manifested in the ability to respond differentially to various stimuli.2,5-Dimethoxy-4-Methylamphetamine: A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.Receptors, Opioid, mu: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Enkephalin, Ala(2)-MePhe(4)-Gly(5)-: An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).

8-Carboxamidocyclazocine: a long-acting, novel benzomorphan. (1/42)

To obtain benzomorphans with a longer duration of action that may be potential therapeutics for treating cocaine abuse, 8-carboxamidocyclazocine was synthesized. The pharmacological properties of 8-carboxamidocyclazocine were compared with the parent compound cyclazocine. Changing the 8-hydroxyl group on cyclazocine to an 8-carboxamido group resulted in only a 2-fold decrease in the affinity of the compound for the kappa-receptor, and no change in the affinity for the mu-opioid receptor, with both compounds having K(i) values of less than 1 nM, based on radioligand binding assays. In the guanosine 5'-O -(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding assay, the two compounds produced moderate stimulation of GTP binding to the human kappa- and mu-receptors. When given by i.c.v. injection, the compounds produced less than 60% antinociception in the mouse 55 degrees C warm-water tail-flick test. However, in the mouse writhing test, the compounds had high potency in producing antinociception. Antinociception induced by either 8-carboxamidocyclazocine or cyclazocine was mediated by both kappa- and mu-opioid receptors. Cyclazocine acted as a mu-antagonist in addition to its agonist properties at the mu-receptor, as measured by the inhibition of morphine-induced antinociception. In contrast, 8-carboxamidocyclazocine did not inhibit morphine-induced antinociception, demonstrating that it was not a mu-opioid receptor antagonist in this assay. An i.p. injection of an ED(70) dose of 8-carboxamidocyclazocine produced antinociception that lasted for 15 h in contrast to cyclazocine, which produced antinociception, lasting 2 h. 8-Carboxamidocyclazocine is a novel, long-acting benzomorphan, which possesses pharmacological properties that are distinct from the properties of cyclazocine.  (+info)

Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia. (2/42)

BACKGROUND AND PURPOSE: Excitatory amino acids and their receptors are involved in mediating ischemic neuronal damage. The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective, hypothermic, and motor deficit effects of the sigma-agonist SKF 10,047 and the N-methyl-D-aspartate antagonist MK-801. METHODS: Neuroprotective effects were compared using an in vitro ischemia model of cultured rat cerebellar granule cells and the gerbil model of global brain ischemia induced by 5 minutes of bilateral carotid artery occlusion followed by 7 days of reperfusion. RESULTS: In vitro, (+)MK-801 protected against 100 microM glutamate with a 50% protective concentration of 30 nM, followed by (-)MK-801 (150 nM), cyclazocine (0.5 microM), (+)SKF 10,047 (3.3 microM), pentazocine (5 microM), and (-)SKF 10,047 (10 microM). In vivo, (+)SKF 10,047 pretreatment (60 mg/kg) or multiple postischemic treatments provided neuroprotection comparable with MK-801 pretreatment (10 mg/kg). When ischemic animals were administered the multiple dosing regimen of (+)SKF 10,047, no hypothermic effect was noted in the temporalis muscle over 4 hours' postischemia. Motor deficits monitored by a swing grid test showed that 50% recovery from (+)SKF 10,047 was 5.5 times faster than recovery from MK-801. CONCLUSIONS: These results are the first to report a hypothermia-free, in vivo neuroprotective effect of (+)SKF 10,047, a prototypical drug of the sigma-agonist class.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC. (3/42)

A series of aryl-containing N-monosubstituted analogues of the lead compound 8-[N-((4'-phenyl)-phenethyl)]-carboxamidocyclazocine were synthesized and evaluated to probe a putative hydrophobic binding pocket of opioid receptors. Very high binding affinity to the mu opioid receptor was achieved though the N-(2-(4'-methoxybiphenyl-4-yl)ethyl) analogue of 8-CAC. High binding affinity to mu and very high binding affinity to kappa opioid receptors was observed for the N-(3-bromophenethyl) analogue of 8-CAC. High binding affinity to all three opioid receptors were observed for the N-(2-naphthylethyl) analogue of 8-CAC.  (+info)

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine. (4/42)

 (+info)

Effects of eptazocine, a novel analgesic, on KCN-induced changes in the cerebral contents of glycolytic metabolites and high-energy phosphates in mice. (5/42)

Effects of eptazocine on cerebral metabolic changes due to a sublethal dose of KCN were investigated in mice. KCN (2 mg/kg, i.v.) induced a temporary loss of consciousness being moderated by eptazocine (1-10 mg/kg) in a dose-dependent manner. The KCN injection decreased the contents of phosphocreatine (PCr), ATP and glucose and increased the contents of AMP and lactate, resulting in a 34% decrease in energy charge potential (ECP) and an increase in lactate/pyruvate (L/P) ratio. Such changes were improved by eptazocine (10 mg/kg) and EKC (3 mg/kg), but not by pentazocine (10 mg/kg) and morphine (3 mg/kg), and the improving effect of eptazocine was completely inhibited by MR-2266 (3 mg/kg), a relatively selective opioid kappa-receptor antagonist. On the other hand, eptazocine (3, 10 mg/kg) was found to increase the glucose content in normal mice, but not to give significant changes in the contents of glycolytic metabolites and high-energy phosphates. These results suggest that eptazocine may improve anoxic changes in cerebral energy metabolism.  (+info)

Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. (6/42)

The well characterized human breast cancer cell line, MCF-7, has been shown to possess membrane receptors for various opioid ligands, and these compounds have been shown to modulate the growth of the cells in culture. Using specific radioligands for the receptor types, we were able to demonstrate that the MCF-7 cells possess multiple opioid receptor types. Relatively high-affinity-binding sites are present for the mu- and kappa-specific ligands, while lower affinity sites are present for the delta-agonist. Opioid ligands specific for the different receptor types significantly inhibited the growth of the MCF-7 cells in a dose-dependent manner when grown in the presence of 10% fetal bovine serum. This inhibitory effect was reversed by the simultaneous administration of the opioid receptor antagonist, naloxone. However, the opioid effect appears to be restricted to the hormonally responsive fraction of the MCF-7 cell growth. Cells grown in the presence of charcoal-stripped fetal bovine serum are refractory to the effects of the opioids unless the media is supplemented with estradiol. The data presented here suggest an important regulatory role for opioids in the growth and development of human breast cancers.  (+info)

Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. (7/42)

1. Opioid receptors in the neonatal rat spinal cord have been characterized by measurements of ligand binding to crude membrane fractions and by functional tests on the nociceptive spinal response in a spinal cord-tail preparation in vitro. 2. There were high affinity binding sites for [3H]-[D-Ala2, MePhe4, Gly(ol)5]enkephalin (DAGOL), [3H]-U69593, and [3H]-ethylketocyclazocine (EKC) on spinal cord membranes from neonatal rats. Hill slopes for binding of [3H]-DAGOL and [3H]-U69593 were close to unity. The Hill slope for binding of [3H]-EKC was less than unity, even after its interactions at mu-receptors had been blocked with 100 nM unlabelled DAGOL. Binding sites for [3H]-[D-Pen2, D-Pen5]enkephalin (DPDPE) could not be detected. 3. In competition assays U50488 was as potent as PD117302 and U69593 in competition for either [3H]-U69593 or [3H]-EKC binding sites. Hill slopes for a range of competing ligands at [3H]-DAGOL or [3H]-U69593 sites were close to unity. Hill slopes for competition at [3H]-EKC sites were less than one. 4. In the spinal cord-tail preparation from neonatal rats, opioid receptor agonists depressed spinal nociceptive responses evoked by application of capsaicin or heat to the tail. The order of potency was DAGOL greater than U69593 = PD117302 greater than morphine greater than U50488 = [D-Pen2, L-Pen5]enkephalin (DPLPE). 5. The antagonist naloxone was about equally potent against DAGOL, morphine and DPLPE, and about ten times less potent against U69593 and PD117302. The effects of U50488 were much less sensitive to blockade by naloxone than the effects of PD11703 or U69593. The Kappa antagonist, nor-binaltorphimine was equipotent against all three Kappa agonists. 6. The absence of delta-binding sites, and the low potency and relatively high sensitivity to naloxone suggest that DPLPE could be working at mu-receptors in the neonatal rat spinal cord. 7. The binding assays show that U50488 has the same affinity as PD1 17302 and U69593 for Kappa-receptors, yet it was less effective in the depression of nociceptive responses. This may be because U50488 has a relatively low efficacy at Kappa-receptors. It is possible that at high concentrations U50488 activates receptors not affected by other Kappa-ligands. These additional receptors may be non-opioid receptors (hence the insensitivity to naloxone), or they could be a subtype of Kappa-opioid receptor.  (+info)

On the mechanism by which midazolam causes spinally mediated analgesia. (8/42)

The electrical current thresholds for pain (ECTP) in the skin of the neck and tail were measured in rats with chronically implanted lumbar subarachnoid catheters. The effects of a benzodiazepine antagonist and a gamma-aminobutyric acid (GABA) antagonist on the analgesic effects of equivalent doses of midazolam, fentanyl, and ketocyclazocine were studied. These were the minimum doses producing maximal segmental analgesia when given intrathecally (i.e., they all caused a significant and maximum increase in ECTP in the tail, which was similar for all three drugs, but no significant change in the ECTP in the neck). Flumazenil (Ro 15-1788) administration caused a parallel shift to the right of the dose-response curve for midazolam spinal analgesia. Segmental analgesia following midazolam was also significantly attenuated (P less than 0.05) when the selective GABA antagonist bicuculline was given intrathecally at the same time as midazolam. The highest dose of bicuculline used (50 pmol) caused no significant attenuation of the segmental analgesic effects of either ketocyclazocine or fentanyl. The authors concluded that the segmental analgesia produced by intrathecal midazolam is mediated by the benzodiazepine-GABA receptor complex that is involved in other benzodiazepine actions.  (+info)

*Cyclazocine

... is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs ... Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting ... Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and ... Freedman, A. M.; Fink, M.; Sharoff, R.; Zaks, A. (1967). "Cyclazocine and Methadone in Narcotic Addiction" (pdf). The Journal ...

*Azocine

These include cyclazocine, pentazocine, and phenazocine. The fully saturated analog of azocine is azocane. Azocine rings are ...

*Volazocine

Benzomorphan ketazocine cyclazocine World Health Organization (2004). "The use of stems in the selection of International ...

*Pentazocine

Cyclazocine (hallucinogenic) Volazocine Stitzel, Robert E. (2004). Modern pharmacology with clinical applications (6 ed.). ...

*8-Carboxamidocyclazocine

Similarly to cyclazocine, 8-CAC acts as an agonist at both the μ and κ opioid receptors, but has a much longer duration of ... Unexpectedly it was discovered that the phenolic hydroxyl group of cyclazocine could be replaced by a carboxamido group with ... 8-Carboxamidocyclazocine (8-CAC) is an opioid analgesic drug related to cyclazocine, invented by medicinal chemist Mark P. ... Part 7: Syntheses and opioid receptor properties of cyclic variants of cyclazocine". Bioorganic & Medicinal Chemistry Letters. ...

*C18H25NO

The molecular formula C18H25NO may refer to: Aminoestradiol Cyclazocine Methorphans Dextromethorphan Levomethorphan ...

*Hallucinogen

... cyclazocine, and dextrorphan in the pigeon". Psychopharmacology. 73 (3): 286-91. doi:10.1007/BF00422419. PMID 6787651. Herling ...

*Phenazocine

It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for ...

*Ciprefadol

... is an opioid analgesic that is an isoquinoline derivative most closely related to cyclazocine and picenadol, with a ...

*Alazocine

Subsequently, other benzomorphans, such as pentazocine (an N-dimethylallylbenzomorphan), cyclazocine (an N- ...

*Sigma-1 receptor

It was found to have affinity for the (+)-stereoisomers of several benzomorphans (e.g., (+)-pentazocine and (+)-cyclazocine), ...

*List of opioids

Cogazocine Cyclazocine Dezocine Eptazocine Etazocine [32][permanent dead link] Ethylketazocine [33] Fedotozine [34] Fluorophen ... 6β-Naltrexol 6β-Naltrexol-d4 Alvimopan AT-076 Binaltorphimine BU09059 Buprenorphine Chlornaltrexamine Clocinnamox Cyclazocine ...

*Pharmaco-electroencephalography

In testing narcotic antagonists (naloxone, cyclazocine) and opioid substitutes (methadone, levomethadyl) in the treatment of ...

*Controlled Drugs and Substances Act

... but not including Cyclazocine (1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(cyclopropylmethyl)-2,6-methano-3-benzazocin-8-ol) and its ...

*List of drugs: Cp-Cz

... cyclazocine (INN) cyclazodone (INN) Cyclessa cyclexanone (INN) cycliramine (INN) cyclizine (INN) cyclobarbital (INN) ...

*Κ-opioid receptor

Benzomorphans Alazocine- partial agonist Bremazocine - highly selective 8-Carboxamidocyclazocine Cyclazocine - partial agonist ...

*Benzomorphan

9-DEHB 8-CAC Alazocine Anazocine Bremazocine Butinazocine Carbazocine Cogazocine Cyclazocine Dezocine Eptazocine Etazocine ...

*List of MeSH codes (D03)

... cyclazocine MeSH D03.383.113.367.350 --- ethylketocyclazocine MeSH D03.383.113.767 --- oxazocines MeSH D03.383.113.767.500 --- ...

*Metazocine

Phenazocine Pentazocine Cyclazocine Org 6582, a functional MAT inhibitor that is otherwise analogous in structure to the parent ...
Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, naloxone is devoid of any psycho
Don Mares, Executive Director of Denver Human Services presented the proclamation for Redefining Possible Day on behalf of Denver Mayor Michael Hancock. "The City of Denver is proud to recognize this portrait series as a change motivator in our community. Redefining Possible seeks to raise awareness about the reality of disability, and we believe it does just that," said Mares. The groundbreaking portrait series examines the lives of twelve people living with spinal cord and brain injury and showcases the power of the human spirit. The portraits were done by Pulitzer Prize-winning photographer Barry Gutierrez. ...
At this point of time, quality education can not be measured in the number of years one has to spend in school but in the effectiveness of such a teacher-student transformation taking place. Quality education must be free and available to everyone. With excellent school facilities, competent teachers, and all other problems given solutions, I think ten years are enough. Why prolong when the basic needs for school are still to be addressed? Redefining quality of education in the Philippines only takes a common sense. The solution, very simple (much more like of a common sense thing than coming up with a seeming bright idea that will only complicate the situation): equip the school with better facilities, free tuition, eradicate corruption from among the departments high-ranking officials to the lowest, and train teachers to become most competent and increase their salaries. It is a thousand times better to have common sense without education, to quote from Robert Green Ingersoll, than to have ...
Clarins Super Restorative Redefining Body Care for Abdomen and Waist 200ml/6.9oz price as low as $53 shop stores & buy Skin Care Products and find best deals
The Lanier Law Firm Redefining Legal Care The attorneys at The Lanier Law Firm provide something not found at every law firm: Legal Care. We care about clients cases. Our focus is on you and your case,
Buy Redefining the French Republic online written by Gino G. Raymond,Alistair Cole,, 9780719071508 at lowest price in India. Heavy Discount. Fast Shipping. Visit online or call @91-11- 45355555
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.: The effects of the opt
NanoLuc luciferase brings new capabilities to research applications such as BRET, Reporter Assays, protein:protein interactions, protein:ligand interactions, protein dynamics, genetically-encoded biosensors and in vivo imaging. The small size and extreme brightness of NanoLuc luciferase make it useful in many situations where other luciferases may fail.
Johns Hopkins University scientists trying to determine why people develop serious mental illness are focusing on an unlikely factor: a common parasite spread by cats. The researchers say the microbes, called Toxoplasma gondii, invade the human brain and appear to upset its chemistry - creating, in some people, the psychotic behaviors recognized as schizophrenia. If tackling the parasite can help solve the mystery of schizophrenia, "its a pretty good opportunity … to relieve a pretty large burden of disease," said Dr. Robert H. Yolken, director of developmental neurobiology at the Johns Hopkins Childrens Center. The cause of schizophrenia is unknown, but both genetic and environmental factors likely play a part, according to the National Institute of Mental Health. Yolken is among the researchers worldwide examining whether certain viral infections can increase the risk of developing the illness. Other studies have focused on flu and herpes viruses as possible triggers." (Click here for the ...
This paper is a summary of a regional case study on gender, land and decentralisation. The main study has two parts: three portraits of women showing different examples of access to natural resources and local leadership; and a general report based on the portraits and on interviews carried out in seven study sites in Maradi and Zinder regions in Niger ...
A new online game Whats Your Number commissioned by FACT and developed by the Royal College of Art invites people from all over the world to test their own understanding of their working life and the traditional notion of eight hours work, eight hours rest and eight hours play. Users will be encouraged to think about their working life in a new way as they answer a series of questions to reveal their own three-digit number. How many will be the traditional eight, eight, eight ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Here, Mugambi and Kirima provide an African worldview of what a community is and it is encouraging to observe that the gist of what they are saying is the same as Shorters Western definition above. John Mbiti (1969:102) confirms this similarity when he states that an African community is based on kinship through blood and betrothal. It is the kinship which controls social relationships between people in a given group which makes a community.. The community fosters fairness, equality and basic rights for its members and encourages and promotes cultural diversity. Mbiti (1969), who is an authority on African traditional values and worldview, explains the community as that in which the traditional life of an individual cannot exist alone; it can only exist corporately. One owes ones existence to others, including contemporaries and those of past generations. One is part of the whole. The community makes, creates, or even produces the individual, who, in turn, depends on the corporate group ...
The prognosis was grim, and doctors agreed the only course of action was to remove the cancerous tissue, which included his entire tongue. Desperate to preserve his quality of life, Grant undertook an alternative treatment of aggressive chemotherapy and radiation. But the choice came at a cost. Skin peeled from the inside of Grants mouth and throat, he rapidly lost weight, and most alarmingly, he lost his sense of taste. Tapping into the discipline, passion, and focus of being a chef, Grant rarely missed a day of work. He trained his chefs to mimic his palate and learned how to cook with his other senses. As Kokonas was able to attest: The food was never better. Five months later, Grant was declared cancer-free, and just a few months following, he received the James Beard Foundation Outstanding Chef in America Award ...
Retention and graduation rates may be good indicators of a college or universitys success, but they have little to do with students personal development as connected learners and contributors to the digital commons.
We use cookies to hold user preferences, store information for the Basket, and provide anonymised tracking data for analysis tools, such as Google Analytics. By continuing to use this website you confirm that you accept our cookie usage.. You can find out more at any time by viewing our Privacy Policy which has a link to our Use of Cookies page.. ...
Engineers, manufacturers, utilities, public and private enterprise, commerce - in fact, anyone that uses water for temperature control - are, for the most part, quite comfortable in the belief that they are operating an effective and safe water system. But how safe are they really?
In this episode of the Brookings Cafeteria podcast, Mark Muro discusses his new report on automation and the workforce. Also, Molly Reynolds explains what is happening in Congress.
UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
UPDATE: Roger Pielke Sr. has his own take on the issue here. An excerpt from his take is quite similar to my own. A single paper referenced with no specifics regarding the critique, my red bold below. My Comment: Wagner is not an expert on the subject of the Spencer and Braswell paper, so he…
It is not enough for outside counsel to be purely high-wattage intellects; they also need to be superior tacticians outstanding communicators and budget watchdogs.
It is not enough for outside counsel to be purely high-wattage intellects; they also need to be superior tacticians outstanding communicators and budget watchdogs.
Once the shooter is dead or apprehended, the top mission for police and EMS is to stop the dying from bleeding and airway compromise
Doing really well in here and you are looking large and in charge. Dont worry I used your share of mustard for you. I too am a mustardoholic.
Human Resource Executive Online is produced by the leading independent magazine for HR executives offering targeted news, columns and features, HR search functions and more.
The DPR and LPR are ready to exchange prisoners and hope that tomorrow, during negotiations in Minsk, theyll be able to agree on this issue. If nothing goes wrong, we can talk about the most massiv ...
The practice of Laboratory Medicine and our ability to deliver quality patient care is being transformed by the intersection of legislative, technological, and demographic changes; each is the driver of change for the other two. At the center of this is the laboratory professional, whose work environment is changing at dizzying speeds: always new tests, new instruments, new methodologies, new information systems, new performance requirements, and new workplace rules ...
was stabbed by a man in the street. During this period, the man continued to stab the woman 120 times and the man quickly fled the scene. 3 ambulance rushed to the scene, the woman has no signs of ...
Originally Posted by snagencyV2.0 damn man, that sux you guys are killin me with the descriptions lol no disrespect or poking at, just find it
Schwartzman has captured the present in this text. Exploring the relationship between the body, design and technology, the book is perplexing and provocative.
The meeting concluded that there is currently insufficient evidence to adopt new case definitions for drug-resistant TB. Drug susceptibility testing (DST), which is key to defining new levels of drug resistance, lacks accuracy for several of the drugs that are used to treat multi drug-resistant (MDR) and extensively drug resistant (XDR)-TB. Secondly, there is insufficient correlation of DST results with clinical response to treatment for several drugs currently used to treat XDR-TB. Thirdly, new drugs are currently undergoing clinical trials, and could prove effective against drug resistant strains. The meeting urged diagnostics companies and TB laboratories to develop better diagnostic tests and also agreed that WHO and technical partners should develop more detailed guidance on XDR-TB treatment.. Prior to results from randomized controlled trials, which are not expected for at least four years, participants called on WHO to lead a process with partners to improve the quality and quantity of ...
It is of no doubt to the large majority of people that eating disorders such as anorexia are a form of illness, but new findings suggest recategorizing the
In recent years, photography has become the most accessible and affordable art form. With this in mind, photographers must drive the medium forward.
In the new healthcare economy, device makers have to rethink how they do business and how they define innovation, writes Ed Yu, principal of PricewaterhouseCoopers Health Industries Innovation & Growth
Peace be upon you, and welcome to my virology blog, I called it ViroMag (for Virology Magazine), and I ask God that you benefit from whatever posted here; and now to the first post in your virology blog! During early days in college, I used to hear that Viruses are the smallest pathogenic agents and…
The term algorithmic business is relatively new, but the practical use of algorithms is already well established in many industries. Gartner says that...
Start with a light weight approximately 30-45% of your 1RM. You may have to guess here, but its a weight that could easily be bench 25+ times if needed. Bench for 8 reps as fast as possible. Rest for 90 seconds and move on to your second set. Your next two sets will be 5 reps and 3 reps respectively. Use a weight that you can move in less than 10 seconds for completed reps. Rest 90 seconds between these. Your next 4 sets will be singles. Your first should be a weight that you can move 10 times, press as quick as possible. Rest 3-5 minutes. Your next single should be a weight you can press 6 times. Rest 3-5 minutes. Your 3rd single is a weight you could press 4 times. Rest 5 minutes. Your last set is your true max. To find this divide what you can press 10 times by .75. This will give you an approximate 1RM. Use a spotter here.. Dips ...
After two injuries halted her string of running achievements, writer Hannah Kokoski redefines what being strong means to her.
She is our challenge.. Defiant and fiery - but so easily turns on the charm with her doe eyes and a smile that you find yourself fighting HARD to keep your smile. Shes cute as a button, and the little snot knows it too.. Her whole life shes looked her challenges in the eye and laughed.. Torticollis? "Puh…watch me straighten my head out". Hypotonia? "Pshaw…you say I wont walk until later? Watch me and my crazy crooked gate at 12 months. (And just wait, Ill run at 15 months).". CF? "Ha! I got this…". And she (mostly) has for six years now.. CF? "I told you…I got this…". But she doesnt.. Something is falling behind.. It could be a tough infection thats skillfully hidden from the throat swab.. Or maybe her "poor" weight gain is exacerbating her CF.. Either way, shes not maintaining weight. In fact, she lost this time.. Worse, her lung functions & saturation levels do not make her pulmonologist happy.. And now the challenger of rules and attitudes and restrictions is going to be ...
In a land where music is embedded in the ramparts of every palace, and the stones of the fort, in each nook and corner, Salim Khans music stands out for its sheer simplicity, and the rare…
Thank you for taking the time to nominate a fellow for TCTMDs "Featured Fellow" section on the Fellows Forum. Nominees should be current general or interventional cardiology fellows who you have supervised or mentored and think should be recognized for a combination of their scholarship, skills, talent, and commitment to top-notch patient care. If your nominee is selected, you will be notified of our selection and alerted when the story appears on TCTMD. Please email [email protected] with any questions ...
The human algorithm is part understanding and part communication. The ability to communicate and apply insights internally and externally is the key to unlocking opportunities to earn relevance. Beyond research, beyond intelligence, the human algorithm is a function of extracting insights with intention, humanizing trends ad possibilities and working with strategists to improve and innovate everything from processes to products to overall experiences.. The idea of the human algorithm is to serve as the human counterpart to the abundance of new social intelligence and listening platforms hitting the market every day. Someone has to be on the other side of data to interpret it beyond routine. Someone has to redefine the typical buckets where data is poured. And someone has to redefine the value of data to save important findings from a slow and eventual death by three-ring binders rich with direction and meaning.. One place where the human algorithm can have an immediate impact is in social media ...
But British Muslims are perhaps no more than a case in point in the Europe and the Lombard League, of Jean-Marie Le Pen, of minuscule regionalism. Muslim differentialist discourse, a counter-racism or a racism in reverse, would seem appropriate in a Britain where culturalist differentialism has, as mentioned, fully internalized the Powellite conception of history as the savage play of ascriptive sympathies and antipathies, in which the "natural" condition of groups of different origins is one in which they are wholly apart, and in which any attempt to mix them would render conflict inevitable. Such is perhaps natural in a Europe that regards itself as tribal territory with precise border controls, in which nations (for some sections of their members) regard themselves as tribes, all ranged above one another according to a tributary model of subalternity. Such, in an age of dubious post modernity, is the consequence of "the new Cartesianism of the irrational".[42] And such is the natural outcome ...
The pool at the Beijing Olympics is called the Water Cube because of its bubbly blue exterior. But beyond its futuristic look, the pool is designed for fast times - as swimmers proved Sunday by shattering a dozen records.
CMS would have you believe that this is about quality and patient safety. Who can argue with those laudable goals? They are so revered as to be sacred, and with good reason. But dont be fooled. This is cost containment masquerading as quality. As we start to see more and more of these unpreventable "never" events proliferating, and more and more payors signing on to the concept of not paying for "errors" you will see that this is really about reducing the total amount that the big payors spend on the care of sick patients, and shifting the risk of caring for the critically ill onto care providers. It is also informative that CMS is focusing on payments to hospitals, which are much more expensive than the payments to physicians, despite the fact that physicians would theoretically be just as sensitive to payment reductions and are in a position to more directly improve the "quality" of care ...
Charles Buchwalter, SVP, Nielsen Online, and Jon Gibbs, SVP, Nielsen Analytics and Insight, were joined by Jeffrey Holecko, media manager, Kimberly-Clark, to discuss the keys to defining a successful online ad campaign.
The MetS is a major health concern in the United States today being more prevalent in older individuals and in populations of specific racial/ethnic backgrounds. Although MetS is defined by a clustering of metabolic abnormalities including hyperglycemia, high blood pressure and central obesity, we propose the addition of pro-inflammatory adipokines (TNF-α, IL-6, Leptin, PAI-1) as well as CRP being incorporated into the physiological evaluation of those at risk for MetS. Much research exists to show that hyperinsulinemia and central obesity are integral to the development of MetS and that inflammatory adipokines and cytokines are increased in response to the development of insulin resistance and central obesity. However, questions remain as to whether or not these are the primary contributors or sole antecedents to the development of MetS. Androgenic steroids have also been proposed to contribute to the pathogenesis of MetS. More research is necessary to determine whether insulin resistance and ...
Studies of the addictiveness of an analgesic, cyclazocine, which is 40 times as potent as morphine, have been conducted at the National Institute of Mental Heal
Buy high quality N-[(2R,3R,3aS,4S,6aS)-hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl]carbamic Acid 1,1-Dimethylethyl Ester 1315552-07-8 from toronto research chemicals Inc.
chemBlink provides information about CAS # 33069-62-4, Paclitaxel, 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv., Taxal, Taxol A, molecular formula: C47H51NO14.
In this edition of Focus, you will also find the extension of the 2015 key trend the quantified workplace into health as a social identification for organizations. In the key trend HEALTH BY DESIGN you can read about the potential of a healthy workplace as a sustainable intervention to shape an active workforce and achieve a strategic advantage over your competition in the recovering economy. Finally, this edition of Focus sketches a revolutionary image of the future of a symbiotic relationship between work and leisure, with the rise of the hotel market as a leading example for the office market. The key trend HOTELS X OFFICE identifies the digital nomads as the new office users who are redefining and realizing the current trend of working independently of place and time in co-working spaces that meet their particular lifestyle. ...
3 MAGNETIC RESONANCE IMAGING 1097 or An redefining the functions in terms of the new variables, s and I, ГГ sГkx, heaart 1в4 IГx, yГeikxxeikyydxdy Г1694Г where I (x, y) is equal to the term in the braces outside the exponentials in Eq. (A) Mohвs defect of the nasal tip.
Strict Standards: Redefining already defined constructor for class WP_Dependencies in /home/httpd/web09603/www/wp-content/plugins/wordpress-support/wordpress-support.php(10) : runtime-created function(1) : eval()d code(1) : eval()d code on line 1 ...
Primary Goal in Life: To be the 3rd nicest person in the Universe. I achieve this goal by constantly redefining the word nicest, which is currently 8735 words long in all its nuances and handling special incidents such as road rage and being attacked by wildlife. I wake up every day looking forward to the next friend that I will make, the piece of art that I will create, and the culinary discovery that makes my taste buds tumble. I not only have favorite pieces of music, I have favorite notes within those pieces ...
Thrive: The Third Metric to Redefining Success and Creating a Life of Well-Being, Wisdom, and Wonder by Arianna Huffington. In Thrive, Arianna Huffington makes an impassioned and compelling case for the need to redefine what it means to be successful in todays world.. Arianna Huffingtons personal wake-up call came in the form of a broken cheekbone and a nasty gash over her eye - the result of a fall brought on by exhaustion and lack of sleep. As the cofounder and editor-in-chief of the Huffington Post Media Group - one of the fastest growing media companies in the world - celebrated as one of the worlds most influential women, and gracing the covers of magazines, she was, by any traditional measure, extraordinarily successful. Yet as she found herself going from brain MRI to CAT scan to echocardiogram, to find out if there was any underlying medical problem beyond exhaustion, she wondered is this really what success feels like?. As more and more people are coming to realize, there is far more ...
My Dad gave me an article this summer that I still cant get off my mind. It celebrates living a life of integrity and kindness instead of focusing on accumulating the more conventional forms of success, like trophies and money. The article, Redefining the Success and Celebrating the Ordinary, explains that "In this world, an ordinary life has become synonymous with a meaningless life." It is absurd how fortunate I am in so many millions of ways. I grew up with all the opportunities in the world - I could be whoever I wanted to be, and I always dreamt big. I was going to be big. Somewhere along the line, that dream changed. Now I just want to enjoy a good life and be a good person. Gracias a Dios, I feel at peace. We fill our youth (and I see this everyday at school) with the ideas that they have to win, win, win to have a meaningful life, but thats bullshit. Now, theres nothing wrong with winning - I personally love it. But whats being promoted is that it is acceptable to do whatever it ...
The debut of the downsized B-Body full size cars in 1977 was a complete success for General Motors, redefining the full size class and introducing a fundamentally sound basic design that would endure […]
Tami Simon: Youre listening to Insights at the Edge. This episode is sponsored by Spirituality & Health magazine: bringing mindful coverage to topics that include faith, philosophy, meditation, and wellness. Please visit spiritualityhealth.com to learn more. Today, my guest on Insights at the Edge is Arianna Huffington. Arianna is the chair, president, and editor-in-chief of The Huffington Post Media Group; a nationally syndicated columnist; and, shes the author of 14 books. In May 2005, she launched The Huffington Post, a news and blog site that quickly became one of the most widely read, linked to, and frequently cited media brands on the Internet. In 2012, the site won a Pulitzer Prize for national reporting. Shes been named to the Forbes Most Powerful Women list and the Time 100-Time magazines list of the worlds 100 most influential people. Arianna has also written a new book called Thrive: The Third Metric to Redefining Success and Creating a Life of Well-Being, Wisdom, and Wonder. ...
Join our Citrix ADC (formerly known as NetScaler ADC) experts for a live, interactive discussion and technical demonstration to see how Citrix is redefining the ADC.
Adapting to the hypoxic microenvironment is crucial for tumor cell growth and survival, and is achieved largely by transcriptional activation of genes that facilitate short- and long-term adaptive responses (42, 43). The HIF-1α pathway is invariably activated under hypoxic conditions and orchestrates a complex transcriptional program geared toward enhancing cell survival in a transiently unfavorable microenvironment (44). We now report for the first time that a large fraction of primary ESFT accumulates HIF-1α protein, presumably reflecting hypoxia induction in those tissues. Our in vitro data show that ESFT cells adapt to hypoxia by redefining their transcriptome and acquiring a distinct hypoxic phenotype characterized by increased invasiveness and anchorage-independent growth.. There is ample experimental evidence that EWS-FLI1 is the major driver of altered gene expression in the pathogenesis of ESFT. In the light of hypoxia increasing the malignant properties of solid tumors, our finding ...
Title: Changing Higher Education, Description: Major changes occurring in the world are redefining the metrics of excellence for higher education., By: Feedage Forager, ID: 979582, Grade: 89, Type: ATOM
Primary Goal in Life: To be the 3rd nicest person in the Universe. I achieve this goal by constantly redefining the word nicest, which is currently 8735 words long in all its nuances and handling special incidents such as road rage and being attacked by wildlife. I wake up every day looking forward to the next friend that I will make, the piece of art that I will create, and the culinary discovery that makes my taste buds tumble. I not only have favorite pieces of music, I have favorite notes within those pieces ...
He will never be the poster child for the jazz world but, British Columbias Tony Wilson is redefining accessible music one show at a time. ; !earshot magazine features campus/community radio charts, cd reviews, articles and interviews, label profiles and more.
She underlines how innovation, such as modern data analytics and decision-making techniques, has benefitted many business sectors while they have not yet been used to transform the regulatory process. She suggests that it is time for the next step of governance reform at EU level, which involves redefining certain parameters of governance as well as the role of the policymaker, and underlines the importance of starting experimenting with new ways of formulating and implementing public policy ...
Graduate course offerings include:. Disability and Public Health. This course will address the evolving view of disability in the field of public health. Students will be introduced to a broad range of topics in order to increase their understanding of the contemporary experience of disability in America. This course will examine how intersection of education, employment and environment impacts the health and well being of people with disabilities. Topics will include: models and approaches to disability; a brief history of public health and overview of epidemiology; a brief history of disability rights; state and federal programs and legislation for people with disabilities; health promotion and the prevention of secondary conditions; health disparities; sexual health; end of life decision-making; and redefining the role of public health in addressing disability.. Epidemiology of Disability. This course will present the fundamental epidemiologic methods applied to disability. Disability issues ...
A report published last week has charted the rise in the UK of a phenomenon known as “mega farms”, the large scale, densely stocked, intensive cattle, poultry and pig farms that are redefining meat and dairy production around the world.
Also many performances on record were changed or shortened, since early recording technology was a slave to the clock and therefore many arias and songs that might have taken 7 or 8 minutes to perform on the stage, were set to fit within the much shorter time available on the early 78 records. Sung to fit the technology, not the quality of the voice of the artist. All of what had to be done changed what was originally put into the recording. It is unfair to judge Caruso on many aspects of his recording legacy, as much of what and how he sang was due to the process, not his style. Also when it came to style, one has to remember it was Caruso who was changing the whole style of how opera was sung. He was redefining it, and in the process did somethings that worked and some that did not. But that is what comes from invention and innovation ...
The current task list is a special kind of to-do list because all the tasks are defined by the next action you need to take to progress them. This simple idea is remarkably effective in helping resolving the kind of inertia that stops us resolving items on our lists. As an example, try picking a stubborn item from your own to-do list and redefining it until it becomes something that actually involves moving one of your limbs. Something necessary but unexciting like "Organise a new fence for the garden" becomes "ring Marcus and ask who fixed his fence". Or, even better with further specifics on how to move your fingers, "dial 2 626 81 19 and ask Marcus who fixed his fence" ...
Daily Burn is redefining fitness with online workout videos, supplements, nutrition & coaching. Streaming at home & on the go. Start your 100% free trial now.
Daily Burn is redefining fitness with online workout videos, supplements, nutrition & coaching. Streaming at home & on the go. Start your 100% free trial now.
Data Collection Notes: In each file, Variables 1-4, 25, and 60 are for identification. Variables 5-24 pertain to the over 10,000 individuals and are presented basically as provided by the principal investigator. Variables 25-59 pertain to the over 3,000 families and were created by ICPSR staff by aggregating or redefining the individual-level data into composite variables for the entire family, or for the head only as the representative of the family. The individual and family data were then merged, producing the two final files. Both files have the same number of variables with identical numbering. Comparable variables for the two years were calculated with identical methods. If data existed for one year and not the other, a dummy variable was inserted as a placeholder for the year without data.. The principal investigator and ICPSR wish to emphasize that the 35 family-level variables included here are not meant to be the only composite variables that could be created. Each researcher may find ...
The Financial Services Agency of Japan has tightened controls regarding Short Selling and announced restrictions prohibiting Naked Short Selling effective October 30th, 2008. Consequently, all clients placing short sell orders must have the required borrow arrangement in advance to ensure delivery on settlement date.. This notice is to inform you of the terminology change whereby Credit Suisse shall not be able to accept any Naked Short Sell orders and therefore will be redefining Short Sell order as Short Sell with Locates order.. Any settlement failure linked to Short Selling will be treated with the highest attention.. We appreciate your full understanding and cooperation to ensure compliance with the new regulation that has been placed on short sell orders. ...
Based on science-backed ingredients and superior quality. Platinum PRE- furthers ONs long history offsetting higher standards by redefining a sports nutrition category. Each serving delivers the energy and focus you need to knock down new personal bests.
Manzano y Rachid El Hour( statistics). Salamanca: Ediciones Universidad de Salamanca, 2016. New York, NY: Springer New York: network Redefining conservatives for recent snubbers: Springer, 2017.
Based out of Huntington Beach, Canna Nano Water is redefining what it means to be green in the cannabis industry. As one of nearly 40 vendors helping...
They claim this equality in just the same way as they claim to not have been a denomination, by playing with defintions. Equality is about value they say, not about role. Yet nothing tells us publicly more about value than the roles you permit and such a defintion is actually a redefintion of equality:. [mass noun] the state of being equal, especially in status, rights, or opportunities:an organization aiming to promote racial equality Oxford Dictionaries. Now that Newfrontiers apparently does not exist (although recognising that this may simply mean that Newfrontiers have redefined the word exist) it will be interesting to follow what happens with the new Apostolic Balls. NB fed up of redefining words they have decided to create new phrases Apostolic Spheres is the current favoured one, but as they contradict Scripture by requiring all their Apostles to have balls (yes a reference to Junia in Romans 16) I figure Apostolic Balls is more appropriate.. ...
By ending the sale of tobacco products in its 7,600 pharmacies, CVS Caremark Corp. is redefining itself as a health-care provider in an environment in which millions of newly insured Americans will be looking for quick and convenient medical care.
The Financial Services Agency of Japan has tightened controls regarding Short Selling and announced restrictions prohibiting Naked Short Selling effective October 30th, 2008. Consequently, all clients placing short sell orders must have the required borrow arrangement in advance to ensure delivery on settlement date.. This notice is to inform you of the terminology change whereby Credit Suisse shall not be able to accept any Naked Short Sell orders and therefore will be redefining Short Sell order as Short Sell with Locates order.. Any settlement failure linked to Short Selling will be treated with the highest attention.. We appreciate your full understanding and cooperation to ensure compliance with the new regulation that has been placed on short sell orders. ...
His s download of structural intellectual at the refinement was found Sartre to engage a knowledge of the of sheet that were as the respondents evaluation was. Sartre was severely in a download the secret of ki. of polished books and redirected VLC-related media to public drive and functional group. His credentials look quantitatively leftmost and get as a download the secret of ki. end of injury of redefining his feedback.
ECHA sudarė cheminių medžiagų, kurios gali atitikti REACH reglamento III priede nustatytus kriterijus, inventorių. Šis inventorius skirtas padėti registruotojams suprasti, ar jie turi įvykdyti tik minimalios ar visos VII priede reikalaujamos informacijos reikalavimus.. Inventorius sudarytas naudojant viešai prieinamas duomenų bazes su eksperimentiniais duomenimis ir (Q)SAR modeliavimo rezultatus. Pavojingų toksikologinių ir ekotoksikologinių savybių duomenys, informacija apie naudojimą ir kita svarbi informacija turi būti sutikrinta su III priede nustatytais kriterijais.. Jei medžiaga neįrašyta į šį sąrašą, tai dar nereiškia, kad ji neatitinka III priede nustatytų kriterijų. Lygiai taip pat jei medžiaga yra šiame inventoriuje, registruotojas vis tiek gali turėti teisę pateikti tik minimalią informaciją, jei tai pateisinama.. Atminkite, kad inventorius nėra klasifikavimo priemonė, jis tik parodo susirūpinimą keliančius požymius. Pavyzdžiui, jei medžiaga ...
The word pain literally means " a highly unpleasant physical sensation caused by illness or injury". If so, what I experienced during the first 3 months of my treatment was something much more than unpleasant or physical. It was a constant affliction that pervaded from the site of injury ie.my right foot upwards to my head. The most agonising moments were when the pain spread stealthily to your mind causing a numbness and freeze hitherto unknown to me in all the 52 years of my life.Being a person prone to resist and disagree with any kind of discomfort this phase of my life taught me many a hard lesson. It set me wondering if one really had to go through such hard times to realise some simple and obviously handy attributes that make life easier and liveable.But I was chosen by some force to know it the hardest way.. My first experience with intense pain was in the naturopathy centre where I took refuge from the " merciless and invasive" world of modern medicine that I had such unreasonable ...
array(2) { [153359]=> object(eZ\Publish\Core\Repository\Values\Content\Content)#5412 (3) { ["fields":protected]=> array(42) { ["title"]=> array(1) { ["eng-GB"]=> object(eZ\Publish\Core\FieldType\TextLine\Value)#5712 (1) { ["text"]=> string(146) "Biodegradable polymer Everolimus-eluting SYNERGY stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial" } } ["url_title"]=> array(1) { ["eng-GB"]=> object(eZ\Publish\Core\FieldType\TextLine\Value)#5724 (1) { ["text"]=> string(38) "SENIOR a randomised single-blind trial" } } ["visibility_date"]=> array(1) { ["eng-GB"]=> object(eZ\Publish\Core\FieldType\Date\Value)#5399 (2) { ["date"]=> NULL ["stringFormat"]=> string(7) "l d F Y" } } ["meta_title"]=> array(1) { ["eng-GB"]=> object(eZ\Publish\Core\FieldType\TextLine\Value)#5397 (1) { ["text"]=> string(146) "Biodegradable polymer Everolimus-eluting SYNERGY stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial" } } ...
To the Editor:. As breast cancer continues to pose a major health risk for women, we can ill afford to engage in semantic arguments about what we should call cancer.. A simple name change for ductal carcinoma in situ of the breast should not unravel decades of clinical trial work dealing with its management. Simply put, we cannot predict which lesions will progress (the majority) versus those that are unlikely to progress (a small subset, primarily in older patients).. What the medical community needs is better class prediction based upon a functional understanding of the individual genomic mechanisms involved. Downgrading all ductal carcinoma in situ to indolent lesions of epithelial origin or pre-cancer makes us fear that insurers will stop paying for lifesaving treatments like radiation therapy, anti-estrogen therapy or, on occasion, mastectomies.. It is the physicians responsibility to chart a critical course of treatment for his patients based on each womans circumstances. Our best chance ...
Abstract Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. A more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. In this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. We describe the age-related upregulation of nuclear factor (NF)-κB signaling, cytokines/chemokines, endoplasmic reticulum (ER) stress, inflammasome, and lipid accumulation. ...
On Jul 22-23 I participated in a Fermenting workshop with Sandor Katz, the author of The Art of Fermentation and Wild Fermentation. Shelburne Farms, just outside Burlington, Vermont hosted the event. If youve been to Shelburne Farms before, we were in the Coach Barn for the event. Over two days we covered the basics of…
Heres a blog post I wrote today - you or someone you love suffers from memory loss, you will be interested to read this. http://www.donnathomson.com/2012/11/redefining-dementia-lets-all-go-to.html PS: I usually post in Child Neuro, but I was inspired to write this today.
Sounds like we are gonna get a little crazy with this post, hmmm? Revolution in the streets!? Only in your minds, my friends. Just like my last meditation about Yoga, this time around I got far more than I was expecting. I am loving the flow of information and the unexpected direction of it all.…
Since the birth of the computer age, the drive to bring products to market faster, better and cheaper has been a shared, unparalleled competitive pressure across every engineering design project, regardless of its size or purpose.While the rapid advances in computer power and technology over the past decade have ushered in such powerful technology drivers as CAD (Computer-Aided Design) and CAE (Computer-Aided Engineering), the greatest engineering design productivity bottleneck for most design projects still remains at the human level ...
Media coverage, proposed legislation, and lexicons influence how the general public views and defines genetic cloning. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
Advances the understanding of complex social-ecological systems with new insights into ecosystem management practices and long-term sustainability
Yellowstones hot spring organisms broadened our understanding of life and changed the way scientists thought about the prospects for life on Mars and beyond. - Faye Flam, Philadelphia Inquirer
by Olaf Immanuel Seel (Ionian University of Corfu, Greece) Description Culture has a significant influence on the emerging trends in translation and i...
konfirmi) Tifluadom [1] estas benzodiazepin derivaĵo kun nekutima agadprofilo. Male al la plej multaj benzodiazepinoj, tifluadom havas neniun agadon ĉe la GABAA receptoro, sed anstataŭe estas selektema agonisto por la κ-opioid receptoro. [2] En konformo, ĝi havas potencan kontraŭdolorilon [3] kaj urinigaj [4] efikoj en bestoj, kaj ankaŭ havas sedativajn efikojn kaj stimulas apetiton.. Dum tifluadom havas plurajn efikojn kiuj eble havos eblajn uzojn en medicino kiel ekzemple analgezio kaj apetitstimulo, κ-opioid agonistoj tendencas produkti nedezirindajn efikojn en homoj kiel ekzemple disforio kaj halucinoj, kaj tiel tiuj medikamentoj tendencas nur esti uzitaj en scienca esplorado. Disforaj efikoj estas similaj al tiuj viditaj kiam uzado de aliaj κ-opioid receptoragonistoj kiel pentazocino kaj salvinorin A.. ...
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione,
Matador is a travel and lifestyle brand redefining travel media with cutting edge adventure stories, photojournalism, and social commentary.
Technology blogger Robert Scoble attended the World Economic Forum at Davos, and made quite a few video recordings of the conversations he had with various people while he was there, which he has uploaded to Qik. In this film, Scoble talks to the Brazilian neuroscientist Miguel Nicolelis, who discussed his recent experiments in which a monkey with a brain-computer interface implanted into its motor cortex controlled the movements of a robot that was located more than 7,000 miles away. Nicolelis presented his results during a session called Redefining the limits of the human body, which included Emory Brown, a computational neuroscientist at MIT, and Hugh Herr, the director of MITs Biomechatronics Group. In this 14-minute film, Scoble talks to Brown, Herr, and Cynthia Breazeal, who heads the Personal Robotics Group (also at MIT). The World Economic Forum YouTube channel includes videos of talks given by British Prime Minister Gordon Brown, Afghani President Hamid Karzai, U.S. Secretary of State ...
Sensory perception comprises gustatory (taste) and olfactory (smell) modalities as well as somatosensory (pain, heat, and tactile mechanosensory) inputs, which are detected by a multitude of sensory receptors. These sensory receptors are contained in specialized ciliated neurons where they detect changes in environmental conditions and participate in behavioral decisions ranging from food choice to avoiding harmful conditions, thus insuring basic survival in metazoans. Recent genetic studies, however, indicate that sensory perception plays additional physiological functions, notably influencing energy homeostatic processes and longevity through neuronal circuits originating from sensory tissues. Here we review how these findings are redefining metabolic signaling and establish a prominent role of sensory neuroendocrine processes in controlling health span and lifespan, with a goal of translating this knowledge towards managing age-associated diseases. PMID: 27067041 [PubMed - indexed for ...
Downloadable (with restrictions)! Many authors have insisted on the necessity of defining poverty as a multi-dimensional concept rather than relying on income or consumption expenditures per capita. Yet, not much has actually been done to include the various dimensions of deprivation into the practical definition and measurement of poverty. Existing attempts along that direction consist of aggregating various attributes into a single index through some arbitrary function and defining a poverty line and associated poverty measures on the basis of that index. All this is merely redefining the more general concept of poverty, which then essentially remains a uni-dimensional concept. On the contrary, the present paper suggests that the only way to truly take into account the multi-dimensionality of poverty is to specify a poverty line for each dimension of poverty and to consider that a person is poor if he/she falls below at least one of these various lines. The paper then explores ways to combine these
Why dont female iguanas get as tame as males?. Why are females always so cranky?. Ive been thinking a bit about adult female igs and why they are so often reported as being bitchy and unfriendly. Having watched the three big adult females around here, as they met and settled in with each other (and, in the process, redefining the existing organizational hierarchy) and having dealt with an assortment of males of various sizes temperaments, it comes to mind that the females are not bitchy or unfriendly - theyre just used to dealing with macho (territorial, posturing, periodically lusty) males.. Where males defend and work to extend territory and try to mate with whatever female walks through or in close proximity to the area, females just cant be bothered with that nonsense, literally and figuratively brushing the males off if they are not receptive to their attentions. It is the females here who get the food first. And first of all females is the new alpha female, Iguanita, who supplanted the ...
Watch the hot porn video Redefining Premature Ejaculation for free right here. Tube8 provides a huge selection of the best Asiatique porn movies and premature XXX videos that you can stream on your computer or mobile device in crisp HD quality.
Ethylenediamine tetraacetic acid (EDTA) was used as a nociceptive stimulus intradermally in the guinea pig. The responses evoked by EDTA included vocalization, biting and scratching at the site of injection and escape behavior. Nociception by EDTA was shown to be the result of its cation chelating activity. The suppression of EDTA-induced responses proved to be a rapid and effective antinociceptive test. The narcotic analgesics morphine, codeine, meperidine and methadone and the narcotic antagonist analgesics cyclazocine, cyclorphan, nalorphine and pentazocine were active. The slopes of the dose-response curves of the narcotic antagonist analgesics were significantly shallower than those of the narcotic analgesics. The test was highly specific for these analgesics. Antipyretic analgesics and various nonanalgesic drugs were inactive. ...
3-methylfentanyl • 3-methylthiofentanyl • Acetorphine • Acetyldihydrocodeine • Acetyldihydrocodeinone • Acetylmorphone • Alfentanil • Allylprodine • α-methylacetylfentanyl • α-methylfentanyl • α-methylthiofentanyl • α-prodine • Anileridine • Bemidone • Benzylmorphine • β-acetylmethadol • β-hydroxyfentanyl • β-hydroxythiofentanyl • β-4-morpholinylethylmorphine • β-prodine • β-meprodine • Bezitramide • Buprenorphine • Butorphanol • Carbetidine • Carperidine • Carfentanil • Clonitazene • Codeine • Codeine-N-Oxide • Codeinone • Cyclazocine • Cyclorphan • Cyprenorphine • Desomorphine • Dextromoramide • Dextropropoxyphene • Dezocine • Diacetyldihydromorphine • Diampromide • Diethylthiambutene • Difenoxin • Dihydrocodeine • Dihydrocodeinone enol acetate • Dihydrohydroxycodeinone • Dihydrodesoxymorphine • Dihydroetorphine • Dihydroheroin • Dihydroisocodeine • Dihydromorphine • Dimenoxadol • ...
AVer proudly announces the release of the latest in the award winning VC Series: the VC322 Video Conferencing System. The VC322 is a 4K PTZ video conferencing system with cloud enabled collaboration support that is specifically designed for use in huddle rooms. Built around the concept of providing an unnoticeable, high quality, simple to use video conferencing system for huddle rooms the VC322s compact design, high quality 4K PTZ camera, and plug-and-play capabilities provide users with a new type of video conferencing experience in their huddle conferencing rooms.
Aims: To assess the rate of tooth movement, anchorage loss, root resorption, and alkaline phosphatase (ALP) activity in the gingival crevicular fluid (GCF) as a marker for bone remodeling during orthodontic space closure using two different mechanisms. Methods: Space closure was completed in 20 patients with extraction of all 4 premolars. Lateral cephalograms and radio visiographs taken before (T1) and after (T2) space closure were assessed for anchorage loss and root resorption. Alkaline phosphatase levels were measured in 10 patients, which were divided into two groups of five each. Spaces were closed with a screw device in the first group and with active tie-backs in the second. Gingival crevicular fluid samples, collected at intervals, were assayed for alkaline phosphatase spectrophotometrically in each patient. Results: The mean rate of tooth movement was 1.32 0.22 mm/month. The mean amount of anchorage loss in the maxilla and mandible was 1.23 0.60 mm and 1.08 0.65 mm, respectively. Sixty ...
Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) comprise a powerful class of tools that are redefining the boundaries of biological research. Although these technologies have begun to enable targeted genome modifications, there remains a need for new technologies that are scalable, affordable, and easy to engineer. In this paper, we propose a new tool for genetic engineering, the pseudocomplementary peptide nucleic acid nucleases (pcPNANs), which are composed of a pseudocomplementary PNA (pcPNA) specific for a DNA target sequence, a FokI nuclease cleavage domain and a nuclear localization signal. pcPNANs may induce targeted DNA double-strand breaks that activate DNA damage response pathways and enable custom alterations. Their cleavage-site is determined by simple Watson-Crick rule, and thus pcPNANs for aimed cleavage of genomes can be straightforwardly designed and synthesized without any selection procedure. Accordingly, the cleavage-site and site-specificity
Maund, David (2008) Moving-on From a Rural Parish: a Multidisciplinary Longitudinal Study of Population Trends and Migration in an Area of the English-Welsh Borderland. PhD thesis, Coventry University in association with the University of Worcester. McKail, R. and Hodge, S. and Daiches, A. and Misca, Gabriela (2017) Life Stories of International Romanian Adoptees: A Narrative Study. Adoption Quarterly, 20 (4). pp. 309-328. ISSN 1092-6755 Online: 1544-452X Misca, Gabriela (2015) Back in Civvy Street: An Exploration of Military Veterans Experiences of Mental Health Services and the Support Needs of Their Families. In: Institute of Health and Society Research Seminar Series 2014-15, 1st July 2015, University of Worcester, Worcester. (Unpublished) Misca, Gabriela (2016) Coming of Age: Stories from the Now-grown Romanian Adoptees. In: Redefining Family Conference: Growing families through adoption, donor conception and surrogacy, 13th - 14th January 2016, Auckland University of Technology, Auckland, ...
The redefining of neuromyelitis optica spectrum disorder (NMOSD) in 2006 has revealed cases with unique and previously unrecognised presentations. We describe a case of an NMOSD relapse in which seizures were the main clinical feature.. A twenty three year old female first presented in 2006, then thirteen with hyponatraemia and bilateral, severe optic neuritis, in the context of hypothalamic and optic chiasm lesions on MRI brain. Central pontine myelinosis was initially diagnosed but this was revised to an acute disseminated encephalomyelitis (ADEM) in 2013. She remained well for nine years albeit with residual neurological disabilities, including mild spastic paraparesis, global hyperreflexia and bilateral extensor plantar responses. She had almost complete loss of vision in both eyes with peripheral sparing evidenced by bilateral optic atrophy. In September 2015 she presented with generalised seizures. MRI brain showed contrast enhancement in the right cingulate gyrus (DWI negative). ...

Cyclazocine - WikipediaCyclazocine - Wikipedia

Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs ... Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting ... Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and ... Freedman, A. M.; Fink, M.; Sharoff, R.; Zaks, A. (1967). "Cyclazocine and Methadone in Narcotic Addiction" (pdf). The Journal ...
more infohttps://en.wikipedia.org/wiki/Cyclazocine

A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLinkA correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats | SpringerLink

Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, ... A correlative evaluation of cyclazocine, LSD and naloxone on continuous discriminated avoidance in rats. *Samuel R. Wray1. ... Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established ... Cyclazocine and LSD administration resulted in periods of response-inhibition and a subsequent enhancement of response rates. ...
more infohttps://link.springer.com/article/10.1007%2FBF00421916

Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro...Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro...

Cyclazocine blocked responses to iontophoretically applied NMA and one component of the postsynaptic response to stimulation, ... and responses to stimulation of the underlying white matter were compared and challenged with the sigma opiate cyclazocine. ... Cyclazocine blocked responses to iontophoretically applied NMA and one component of the postsynaptic response to stimulation, ... Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: an intracellular, in vitro ...
more infohttps://www.semanticscholar.org/paper/Selective-blockade-of-an-excitatory-synapse-in-rat-Thomson-Lodge/46e5b0ac0510f0c58c49e8cbe919ebc0e22c7ba1

Azocine - WikipediaAzocine - Wikipedia

These include cyclazocine, pentazocine, and phenazocine. The fully saturated analog of azocine is azocane. Azocine rings are ...
more infohttps://en.wikipedia.org/wiki/Azocine

Meylers Side Effects of Drugs - Elsevier Science & Technology - Literati by CredoMeyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo

This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
more infohttps://corp.credoreference.com/component/booktracker/edition/11102.html

HydromorphoneHydromorphone

Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine 4- ...
more infohttp://www.bionity.com/en/encyclopedia/Hydromorphone.html

ThebaineThebaine

Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine 4- ...
more infohttps://www.bionity.com/en/encyclopedia/Thebaine.html

StateMaster - Encyclopedia: MorphineStateMaster - Encyclopedia: Morphine

Ketazocine (INN) is a cyclazocine derivative used in opioid receptor research. ... Metazocine is an opioid analgesic related to ... 5,9-DEHB • Anazocine • Bremazocine • Cogazocine • Cyclazocine • Dezocine • Eptazocine • Etazocine • Ethylketocyclazocine • ... 5-Guanidinonaltrindole • β-Funaltrexamine • Binaltorphimine • Cyclazocine • Cyclohexyl-alpha-phenethylallylamine • ... Cyclazocine is a mixed opiate agonist-antagonist. ... Diprenorphine (Revivon, M5050) is an opiate antagonist used to reverse ...
more infohttp://www.statemaster.com/encyclopedia/Morphine

PentazocinePentazocine

... cyclazocine; 2-Dimethylallyl-5,9-dimethyl-2-hydroxybenzomorphan; 2-(3,3-Dimethylallyl)-2,2-hydroxy-5,9-dimethyl-6,7- ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C359831&Units=SI&Mask=FFFF

STP : main GiPCRsSTP : main GiPCRs

cyclazocine or N-allylnormetazocine , morphine. SKF 10047 benzomorphans * dextrorphan (DXO). igmesine neuroleptics, ...
more infohttp://www.ufrgs.br/imunovet/molecular_immunology/stpgipcrs.html

Why methadone maintenance worksWhy methadone maintenance works

The most recent study of cyclazocine, reported in the International Journal of the Addiction, 3 in 1971, indicates that of 186 ... Among them are the narcotic antagonists; cyclazocine and nalaxone are examples. An addict who injects heroin while on one of ... The study suggests, but does not prove, that the few patients who accept cyclazocine do significantly better than similar ... 3. John N. Chappel, Edward C. Senay, and Jerome H. Jaffe, Cyclazocine in a Multi-Modality Treatment Program: Comparative ...
more infohttp://druglibrary.org/schaffer/library/studies/cu/CU17.html

LIST OF DEPRESSANTSLIST OF DEPRESSANTS

Discussion of depressants, also known as downers. This class of drugs include alcohol, barbiturates (such as Xanax and Valium), benzodiazepines (such as Librium, Ativan & Klonopin), and most famously, cannabis.
more infohttp://omnivoid.forumotion.com/t21-list-of-depressants

Ciklazocin - WikipediaCiklazocin - Wikipedia

"Cyclazocine and Methadone in Narcotic Addiction". http://jama.ama-assn.org/content/202/3/191.full.pdf. ... "Cyclazocine revisited - Neurochemical Research" 21 (11). pp. 1369-1373. doi:10.1007/BF02532378 ...
more infohttps://sh.wikipedia.org/wiki/Ciklazocin

Patent US5413996 - Targeted drug delivery via phosphonate derivatives - Google PatentsPatent US5413996 - Targeted drug delivery via phosphonate derivatives - Google Patents

... cyclazocine and phenazocine; and those of the codeine series, such as codeine, oxycodone, drocode and pholcodine. ...
more infohttp://www.google.com/patents/US5413996?dq=7751826

StateMaster - Encyclopedia: HydroxypethidineStateMaster - Encyclopedia: Hydroxypethidine

Cyclazocine is a mixed opiate agonist-antagonist. ... Dextromoramide (Palfium®, Palphium®, Jetrium®, Dimorlin®) is the ... Cyclazocine • Cyclorphan • Cyprenorphine • Desomorphine • Dextromoramide • Dextropropoxyphene • Dezocine • ...
more infohttp://www.statemaster.com/encyclopedia/Hydroxypethidine

ҩƷ?? ???? ?? ??  - ??óרҵ???? | Bridgat.comҩƷ?? ???? ?? ?? - ??óרҵ???? | Bridgat.com

Cyclazocine. ƶ ??Ԫ Daidzein. Ƽд?? Peruvoside. Ƽ?? Thevetin. ??Ȳ ???? Yellow Fever Vaccine. ???? Fibrauretin. ??????? Lutrelin. ...
more infohttp://article.bridgat.com/language/term/200803/049.html

Medical Isotopes, Inc.Medical Isotopes, Inc.

Keto Cyclazocine. Details Inquire 65741. Keto Tiagabine Tosylate. Details Inquire 27478. rac-trans-Ketoconazole. Details ...
more infohttp://medicalisotopes.com/custom_synthesis.php?alpha=K

OB drugs effects pregnancy-1 - Benha University Hospital Email elnashar53@hotmail.com Impact of the problem Egypt 86 takes...OB drugs effects pregnancy-1 - Benha University Hospital Email [email protected] Impact of the problem Egypt 86 takes...

... cyclazocine 4. Anticonvulsant B C D Mg sulphate Carbamazepine Phenytoin (Dilantin): Hydantoin syndrome Metharbital (tegretol): ...
more infohttps://www.coursehero.com/file/6643226/OB-drugs-effects-pregnancy-1/

Plus itPlus it

A laboratory study of hydromorphone and cyclazocine on smoking behavior in residential polydrug users. Pharmacol Biochem Behav ...
more infohttp://cebp.aacrjournals.org/content/23/9/1793

C-化学物质数据库C-化学物质数据库

Cyclazocine(Narcotic antagonist.). *Cyclethrin. *Cyclexanone(Antitussive.). *Cyclexedrine(Sympathomimetic; anorexic.). *Cyclic ...
more infohttps://www.drugfuture.com/chemdata-c.html

Hallucinogen - WikipediaHallucinogen - Wikipedia

... cyclazocine, and dextrorphan in the pigeon". Psychopharmacology. 73 (3): 286-91. doi:10.1007/BF00422419. PMID 6787651.. ...
more infohttps://en.m.wikipedia.org/wiki/Hallucinogen

CiNii Articles - WATANABE YozoCiNii Articles - WATANABE Yozo

Double-blind Controlled Study of Cyclazocine and Pentazocine in the Treatment of Post-surgical Pain (1983) ...
more infohttps://ci.nii.ac.jp/author?q=WATANABE+Yozo

Plus itPlus it

D-EKC and D-cyclazocine, which bind to sigma sites, had no effect on corticosterone.(ABSTRACT TRUNCATED AT 250 WORDS) ... The agonist/antagonists, butorphanol and cyclazocine, when injected, behaved like kappa agonists and increased plasma ...
more infohttp://jpet.aspetjournals.org/content/238/2/429

Diagnosis and Treatment of Opioid Dependence | SpringerLinkDiagnosis and Treatment of Opioid Dependence | SpringerLink

Kleber, H. D., Kinsella, J. K., Riordan, C., Greaves, C., and Sweeney, D., 1974, The use of cyclazocine in treating narcotic ... Resnick, R. B., Fink, M., and Freedman, A. M., 1970, A cyclazocine typology in opiate dependence, Amer. J. Psychiat. 126: 1256- ... Freedman, A. M., Fink, M., Sharoff, R., and Zaks, A., 1968, Clinical studies of cyclazocine in the treatment of narcotic ... Kissin, B., Ottomanelli, G., Sang, E., and Halloran, G., 1973, Cyclazocine treatment for heroin addicts, in Proceedings of the ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-3866-6_8

Holy Trinity student at National Spelling Bee. Will Dhyana Mishra win?Holy Trinity student at National Spelling Bee. Will Dhyana Mishra win?

Sebastian Castilla reacts after he spells word cyclazocine during the 2019 Scripps National Spelling Bee, May 30, 2019. Jack ...
more infohttps://www.floridatoday.com/story/news/2019/05/29/2019-national-spelling-bee-dhyana-mishra/1268942001/
  • Jaffe, J. H., Brill, L.: Cyclazocine, a long acting narcotic antagonist: its voluntary acceptance as a treatment modality by narcotics abusers. (springer.com)
  • Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established discriminated (Sidman) avoidance performance in rats. (springer.com)
  • The effects of cyclazocine and LSD in rats may be mediated through similar mechanisms. (springer.com)
  • Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting treatment of narcotic addiction was severely hampered by the drug's psychotomimetic, dysphoric, and hallucinatory effects. (wikipedia.org)
  • The most recent study of cyclazocine, reported in the International Journal of the Addiction, 3 in 1971, indicates that of 186 addicts offered cyclazocine, 33 accepted, of whom 11 were believed to be abstinent twenty months later. (druglibrary.org)
  • Replacement of the phenolic hydroxyl group in non-peptide opiates with the −CONH 2 group had previously been shown to result in compounds retaining high μ receptor binding affinity 5 , 6 and introduction of a (4'-phenyl)-phenethyl substituent at the −CONH 2 group of 8-carboxamido-cyclazocine did not diminish μ receptor binding affinity. (pubmedcentralcanada.ca)