A direct-acting SMOOTH MUSCLE relaxant used to dilate BLOOD VESSELS.
Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Medicines that can be sold legally without a DRUG PRESCRIPTION.
Services providing pharmaceutic and therapeutic drug information and consultation.
The self administration of medication not prescribed by a physician or in a manner not directed by a physician.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
Drugs that cannot be sold legally without a prescription.
A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
A worm-like blind tube extension from the CECUM.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Isomeric forms and derivatives of butanol (C4H9OH).
The study of the heart, its physiology, and its functions.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The hollow, muscular organ that maintains the circulation of the blood.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.
A phosphodiesterase 4 inhibitor with antidepressant properties.
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Radiography of the vascular system of the brain after injection of a contrast medium.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
GENETIC PHENOMENA characterizing IMMUNITY and the immune response.
Compounds that specifically inhibit PHOSPHODIESTERASE 5.
A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).

Effect of cyclandelate on dementia. (1/3)

Cyclandelate, a vasodilator, was administered to 24 patients with dementia. The dementia in these patients was presumed to be due to cerebral ischemia caused by atherosclerosis in cerebral vessels after other possible causes were ruled out. In a double-blind, cross-over study, patients received 200 mg of cyclandelate four times daily for six weeks and a placebo for six weeks. Six psychological tests, which reflect various aspects of higher cortical ability, were used to evaluate the effect of cyclandelate on the dementia. Cyclandelate was found to be no more effective than placebo in improving higher cortical function in these demented patients.  (+info)

Differences in endogenous esterification and retention in the rat trachea between budesonide and ciclesonide active metabolite. (2/3)

The airway retention of inhaled glucocorticosteroids (GCs) depends largely on their lipophilicity. Inhaled budesonide (BUD) becomes highly lipophilic reversibly by the formation of esters acting as a reservoir of active BUD. Ciclesonide (CIC) was also reported to form esters after hydrolysis to active metabolite (CIC-AM). We have investigated lipophilicity and airway retention of BUD, CIC/CIC-AM, fluticasone propionate (FP), and mometasone furoate (MF), and compared esterification of BUD and CIC-AM and its contribution to GC airway retention. Rat tracheas were preincubated with the esterification inhibitor cyclandelate or vehicle. A (3)H-GC ( approximately 10(-7) M: BUD, CIC, CIC-AM, FP, MF) was added for 20 min. After incubation, one half of the trachea was used for analysis of GC uptake and the other to analyze GC release during 3 h in drug-free medium. GC species in trachea halves were analyzed by radiochromatography. At 20 min, the uptake of BUD was similar to that of CIC/CIC-AM; however, the BUD-ester pool was 9-fold greater (p < 0.01). BUD overall retention in trachea at 3 h was greater than that of other GCs (p < 0.01), and the BUD-ester pool was 3-fold greater than the CIC-AM-ester pool (p < 0.01). Cyclandelate decreased the initial BUD- and CIC-AM-ester pools (p < 0.01), and reduced the overall retention of BUD at 3 h (p < 0.01) but not of CIC-AM. Thus, BUD becomes esterified in the airways more promptly and to a greater extent than CIC-AM, and BUD esterification prolongs BUD airway retention. In contrast, airway retention of CIC-AM and CIC seems to be determined mainly by their lipophilicity, similar to FP and MF, which are not esterified.  (+info)

Treatment of early diabetic retinopathy with cyclandelate. (3/3)

In order to assess the effect of cyclandelate on the abnormal permeability of the blood-retinal barrier which occurs in diabetic patients before any other lesions are apparent in the retina a well-controlled, double blind, and paired trial was carried out in 22 patients. The treatments were randomised. The permeability of the blood-retinal barrier was assessed by vitreous fluorophotometry. Each patient was examined before being involved in the trial and then another 3 times with 1 month's interval. The total duration of treatment was 3 months. The results showed that the breakdown of the blood-retinal barrier as evidenced by the degree of abnormal fluorescein penetration into the vitreous suffered a significant decrease in the diabetic patients treated with cyclandelate when compared to the patients submitted to placebo administration, and this effect is particularly apparent in the third month of treatment.  (+info)

This website contains sets of curricular materials on energy use and renewable energy sources, organized into units of instruction for Grades K-2, 3-5, 6-8, and 9-12. Topics covered ...
Ciclesonide is a corticosteroid. It prevents the release of substances in the body that cause inflammation. Ciclesonide is used to prevent asthma attacks in adults and children who are at least 12 years. Ciclesonide may also be used for purposes not listed in this medication guide.
Ciclesonide - Get up-to-date information on Ciclesonide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Ciclesonide
Ciclesonide - Get up-to-date information on Ciclesonide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Ciclesonide
Cyclandelate VP (nerve agent) Homosalate Bell, GD; Clegg, RJ; Ellis, WR; Middleton, B; White, DA (January 1984). "The effects ... 3,3,5-Trimethylcyclohexanol is a precursor to the vasodilator cyclandelate, the sunscreen component homosalate and the VP nerve ...
The drugs cyclandelate and homatropine are esters of mandelic acid. Merck Index, 11th Edition, 5599. Bjerrum, J., et al. ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
... combinations C04AF01 Kallidinogenase C04AX01 Cyclandelate C04AX02 Phenoxybenzamine C04AX07 Vincamine C04AX10 Moxisylyte C04AX11 ...
Cyclaine cyclandelate (INN) Cyclapen-W cyclarbamate (INN) cyclazocine (INN) cyclazodone (INN) Cyclessa cyclexanone (INN) ...
The molecular formula C17H24O3 may refer to: Cyclandelate, a vasodilator Onchidal, a naturally occurring neurotoxin Shogaols, ...
... is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynaud's disease. It is also used to ...
... , also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction.[1] It is an α1-adrenergic antagonist.[2] In the United Kingdom, Moxisylte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Reynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.[3][4] ...
Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynauds disease. It is also used to ...
Cyclandelate.. Br Med J 1967; 2 doi: https://doi.org/10.1136/bmj.2.5552.622 (Published 03 June 1967) Cite this as: Br Med J ...
Other names: Benzeneacetic acid, «alpha»-hydroxy-, 3,3,5-trimethylcyclohexyl ester; Mandelic acid, 3,3,5-trimethylcyclohexyl ester; Arto-espasmol; BS 572; Capilan; Ciclospasmol; Clandilon; Cyclolyt; Cyclomandol; Cyclospasmol; Dilatan; «alpha»-Hydroxybenzeneacetic acid 3,3,5-trimethylcyclohexyl ester; Perebral; Saiclate; Sancyclan; Sepyron; Spasmione; Spasmocyclon; Spasmocyclone; 3,3,5-Trimethylcyclohexanol «alpha»-phenyl-«alpha»-hydroxyacetate; 3,5,5-Trimethylcyclohexyl amygdalate; 3,3,5-Trimethylcyclohexyl mandelate; Cyclergine; Cyclobral; Natil; Novodil; 3,5,5-Trimethylcyclohexanol, mandelic acid ester; 3,5,5-Trimethylcyclohexyl mandelate ...
Literature References: Prepn: N. Brock et al., Arzneim.-Forsch. 2, 165 (1952); A. B. H. Funcke et al., ibid. 3, 503 (1953); van Sluis, Chem. Prod. 17, 375 (1954); GB 707227; W. T. Nauta, US 2707193 (1954, 1955 both to Brocades-Stheeman). Purification: D. Flitter, US 3663597 (1972 to Am. Home Prods.). Pharmacokinetics: A. Orr, J. R. Whittier, Int. J. Nucl. Med. Biol. 1, 205 (1974). GLC determn in human plasma: G. Andermann, M. Dietz, J. Chromatogr. 223, 365 (1981). Clinical trial in chronic cerebrovascular disease: S. Bassi et al., Br. J. Clin. Pract. 38, 344 (1984). Review of efficacy as cerebral and peripheral vasodilator: C. B. Blakemore, ibid. 34, Suppl., 3-9 (1984). Symposium on calcium modulation and clinical effects: Drugs 33, Suppl. 2, 1-141 (1987). Comprehensive description: C. M. Shearer, Anal. Profiles Drug Subs. Excip. 21, 149-168 (1992). ...
Willow Birch Pharma is a leading FDA-Registered / VAWD Accredited supplier of Active Pharmaceutical Ingredients (APIs) to the US Compounding Industry.. ...
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The revised and updated 2011 edition of the most accessible, comprehensive and affordable guide to prescription and nonprescription drugs. The classic guide to all major prescription and nonprescription drugs, featuring revised, up-to date FDA information and an A-Z list of medical conditions and their commonly used drugs for easy reference. It includes coverage of dosage and length of time before the drug takes effect, side effects, special precautions, interactions with other food and drugs, standards for use by different age groups, and much more. It also features a generic and brand name directory, a comprehensive glossary, and complete index by generic, brand, and class name.
Schedule H is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
... cyclandelate; dipyridamole; isoxsuprine; chlorpromazine; haloperidol; yohimbine; and trazodone. ...
alcohol secundario (es); 第2級アルコール (ja); Alcool secondaire (fr); alkohol drugorzędowy (pl); вторичный спирт (ru); 仲醇 (lzh); 이차 알코올 (ko); secondary alcohol (en); sekundara alkoholo (eo); sekundární alkohol (cs); 仲醇 (zh) każdy alkohol, w którym grupa hydroksylowa przyłączona jest do drugorzędowego atomu węgla (pl) вторичные спирты (ru); Alcool Secondaire (fr); 2차 알코올 (ko); secondary alcohols (en); alkohole drugorzędowe (pl ...
Analgesics/anti-inflammatory agents Etodolac (high severity rating [H]) Indomethacin (H) Fenoprofen (H) Ibuprofen (H) Ketorolac (H) Meloxicam (H) Meperidine (H) Naproxen (H) Oxaprozin (H) Pentazocine (H) Piroxicam (H) Propoxyphene (low severity rating [L]) Trimethobenzamide (H) Antiarrhythmics Amiodarone (H) Dofetilide (H) Dronedarone Proca...
Cyclandelate.. Two new Class II studies reported conflicting results. The first study showed cyclandelate to be no more ... Cyclandelate in the prophylaxis of migraine: a placebo-controlled study. Cephalalgia 2001;21:66-70. ... Clinical efficacy and central mechanisms of cyclandelate in migraine: a double-blind placebo-controlled study. Funct Neurol ... The original guideline concluded cyclandelate was probably effective for migraine prevention.. ...
Cyclandelate Peripheral Vasodilator and Cerebral Activator Secondary Hypertension. Generic Name(S). Class. ...
Cyclandelate VP (nerve agent) Homosalate Bell, GD; Clegg, RJ; Ellis, WR; Middleton, B; White, DA (January 1984). "The effects ... 3,3,5-Trimethylcyclohexanol is a precursor to the vasodilator cyclandelate, the sunscreen component homosalate and the VP nerve ...
DB04838 Cyclandelate. DB01023 Felodipine. DB00996 Gabapentin. DB00308 Ibutilide. DB00270 Isradipine. DB00653 Magnesium Sulfate ... DB04838 Cyclandelate. DB01023 Felodipine. DB00996 Gabapentin. DB00308 Ibutilide. DB00270 Isradipine. DB00653 Magnesium Sulfate ...
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Molecular Formula: (netpeptide)C65H87N13O15S2 M.W/Mr.1354.6 Sequence: NOTA-D-Phe-Cys-1-Nal-D-Trp-Lys-Thr-Cys-Thr(ol), cyclic disulfide
... Product Name: Desethyl Sildenafil Synonyms: Desethyl Sildenafil CAS: 139755-91-2 MF: C20H26N6O4S MW: 446.52324 Product Categories: Aromatics;Heterocycles;Intermediates and Fine Chemicals;Metabolites and Impurities;Pharmaceuticals;Sulfur and Selenium Compounds Usage And Synthesis Chemical Properties Off-White Solid Usage A metabolite of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.
... cyclandelate and isoxsuprine; chlorpromazine; haloperidol; yohimbine; Rec15/2739; trazodone; naturally occurring prostaglandins ...
This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
Cyclandelate. The therapeutic efficacy of Mineral oil can be decreased when used in combination with Cyclandelate.. Approved. ...
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Cyclandelate. The risk or severity of hypotension can be increased when Tolazoline is combined with Cyclandelate.. Approved. ...
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CYCLANDELATE. Tab. 100 mg K. Tab. 200 mg K. CYCLOPENTOLATE HYDROCHLORIDE. Col. 1% 15 ml K ...
Cyclandelate *Cyclan *Cyclospasmol *more causes...» See full list of 39 medications causing Tingling toe ...
CyclandelateIBA 10/01/1984 - "Chronic cerebrovascular disorders: a clinical study with cyclandelate.". 01/01/1984 - "Clinical ... 01/01/1987 - "Thus, when used in the setting of general practice, cyclandelate seems to be a safe and apparently effective ... 01/01/1987 - "To investigate the perceived efficacy and safety of cyclandelate when used in general practice, an open ... 01/01/1987 - "Perceived efficacy of cyclandelate in the treatment of cochleovestibular and retinal disturbances related to ...
Cyclandelate 200mg viagra. *Que son las viagras yahoo. * Section III Botteghin viagra and siempre funciona el sildenafil. ...
0058] (5) Peripheral vasodilators (such as ifenprodil tartrate, cinepazide maleate, cyclandelate, cinnarizine and ...
  • Limitations cited as tumour of septic abortion with loss of leaves the products of the fistula) separately examine her only seconds, although its derivatives, cyclandelate (cyclospasmol), pentoxifylline, ketanserin (chapter 26). (rainierfruit.com)
  • Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynaud's disease. (wikipedia.org)
  • 3,3,5-Trimethylcyclohexanol is a precursor to the vasodilator cyclandelate, the sunscreen component homosalate and the VP nerve agent. (wikipedia.org)
  • In the pharmaceutical industry can be used for intermediate methyl benzoylformate, cefamandole, vasodilator Cyclandelate, eyedrops Hydrobenzole, cylert etc, also can be used as a preservative. (finchemical.com)
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  • The seizure regularity was 2C3 each year throughout youth Cyclandelate and youthful adulthood despite antiepileptic medicines, which improved just following the initiation of perampanel around age group 50 years. (aqualogy.org)
  • Cyclandelate is expensive, so trying Tadalafil as an alternative approach now. (amberchildsafety.com)