Cyclohexylamines
Sweetening Agents
Taste qualities of solutions preferred by hamsters. (1/25)
Molecules of diverse chemical structure are sweet to humans and several lines of evidence (genetic, physiological, behavioral) suggest that there may be distinct sweet perceptual qualities. To address how many perceptual categories these molecules elicit in hamsters (Mesocricetus auratus), we studied patterns of generalization of conditioned taste aversions for seven sweeteners: 100 mM sucrose, 320 mM maltose, 32 mM D-phenylalanine, 3.2 mM sodium saccharin, 16 mM calcium cyclamate, 10 mM dulcin and 32 mM sodium m-nitrobenzene sulfonate. Each stimulus was preferred versus water in two-bottle intake tests and stimulated the chorda tympani nerve. For each of seven experimental groups the conditional stimulus (CS) was a sweetener and for the control group the CS was water. Apomorphine.HCl was injected i.p. after a CS was sampled and, after recovery, test stimuli (TS) were presented for 1 h daily. The intake (ml) of each TS consumed by experimental animals was compared with mean TS intake by the control group. Learned aversions for 18/21 stimulus pairs cross-generalized, resulting in a single cluster of generalization patterns for the seven stimuli. Cross-generalization failures (maltose-cyclamate, maltose-sucrose, cyclamate-NaNBS) may be the consequence of particular stimulus features (e.g. salience, cation taste), rather than the absence of a 'sucrose-like' quality. The results are consistent with a single hamster perceptual quality for a diverse set of chemical structures that are sweet to humans. (+info)Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates. (2/25)
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these were metastatic colon carcinoma (rhesus; 500 mg/kg), metastatic hepatocellular carcinoma (cynomolgus; 500 mg/kg), and a small, well differentiated adenocarcinoma of the prostate (cynomolgus; 100 mg/kg). Benign tumors were found at necropsy in three females; these were adenoma of the thyroid gland (rhesus; 100 mg/kg) and two cases of leiomyoma of the uterus (rhesus; 100 mg/kg and 500 mg/kg). No tumors were detected in an age-matched control group of 16 monkeys. Examination of the testes revealed complete testicular atrophy in one of the old cyclamate monkeys, and focal germ cell aplasia (Sertoli-only tubules) in two other cyclamate monkeys. Focal spermatogenic interruption (maturation arrest) at various germ cell levels mixed with normal spermatogenesis was observed in both the cyclamate-treated and the control monkeys, all of which were over 20 years old. Measurements of terminal cyclohexylamine concentrations showed that three of the males dosed with cyclamate at 500 mg/kg were high converters, with plasma concentrations comparable to the levels that produce testicular atrophy in rats. However, only one of the three high converters showed histologic evidence of irregular spermatogenesis. The overall conclusion is that the testicular abnormalities and the sporadic cases of different malignancies found after more than 20 years of dosing do not provide clear evidence of a toxic or carcinogenic effect of sodium cyclamate in monkeys. (+info)Pseudo-streaming potentials in Necturus gallbladder epithelium. I. Paracellular origin of the transepithelial voltage changes. (3/25)
Apparent streaming potentials were elicited across Necturus gallbladder epithelium by addition or removal of sucrose from the apical bathing solution. In NaCl Ringer's solution, the transepithelial voltage (Vms) change (reference, basolateral solution) was positive with sucrose addition and negative with sucrose removal. Bilateral Cl- removal (cyclamate replacement) had no effect on the polarity or magnitude of the Vms change elicited by addition of 100 mM sucrose. In contrast, bilateral Na+ removal (tetramethylammonium [TMA+] replacement) inverted the Vms change (from 2.7 +/- 0.3 to -3.2 +/- 0.2 mV). Replacement of Na+ and Cl- with TMA+ and cyclamate, respectively, abolished the change in Vms. Measurements of cell membrane voltages and relative resistances during osmotic challenges indicate that changes in cell membrane parameters do not explain the transepithelial voltage changes. The initial changes in Vms were slower than expected from concomitant estimates of the time course of sucrose concentration (and hence osmolality) at the membrane surface. Paired recordings of the time courses of paracellular bi-ionic potentials (partial substitution of apical Na+ with tetrabutylammonium [TBA+]) revealed much faster time courses than those produced by sucrose addition, although the diffusion coefficients of sucrose and TBACl are similar. Hyperosmotic and hypoosmotic challenges yielded initial Vms changes at the same rate; thereafter, the voltage increased with hypoosmotic solution and decreased with hyperosmotic solution. These late voltage changes appear to result from changes in width of the lateral intercellular spaces. The early time courses of the Vms changes produced by osmotic challenge are inconsistent with the expectations for water-ion flux coupling in the junctions. We propose that they are pseudo-streaming potentials, i.e., junctional diffusion potentials caused by salt concentration changes in the lateral intercellular spaces secondary to osmotic water flow. (+info)Different functional roles of T1R subunits in the heteromeric taste receptors. (4/25)
The T1R receptors, a family of taste-specific class C G protein-coupled receptors, mediate mammalian sweet and umami tastes. The structure-function relationships of T1R receptors remain largely unknown. In this study, we demonstrate the different functional roles of T1R extracellular and transmembrane domains in ligand recognition and G protein coupling. Similar to other family C G protein-coupled receptors, the N-terminal Venus flytrap domain of T1R2 is required for recognizing sweeteners, such as aspartame and neotame. The G protein coupling requires the transmembrane domain of T1R2. Surprisingly, the C-terminal transmembrane domain of T1R3 is required for recognizing sweetener cyclamate and sweet taste inhibitor lactisole. Because T1R3 is the common subunit in the sweet taste receptor and the umami taste receptor, we tested the interaction of lactisole and cyclamate with the umami taste receptor. Lactisole inhibits the activity of the human T1R1/T1R3 receptor, and, as predicted, blocked the umami taste of l-glutamate in human taste tests. Cyclamate does not activate the T1R1/T1R3 receptor by itself, but potentiates the receptor's response to l-glutamate. Taken together, these findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor. (+info)Artificial sweeteners--do they bear a carcinogenic risk? (5/25)
Artificial sweeteners are added to a wide variety of food, drinks, drugs and hygiene products. Since their introduction, the mass media have reported about potential cancer risks, which has contributed to undermine the public's sense of security. It can be assumed that every citizen of Western countries uses artificial sweeteners, knowingly or not. A cancer-inducing activity of one of these substances would mean a health risk to an entire population. We performed several PubMed searches of the National Library of Medicine for articles in English about artificial sweeteners. These articles included 'first generation' sweeteners such as saccharin, cyclamate and aspartame, as well as 'new generation' sweeteners such as acesulfame-K, sucralose, alitame and neotame. Epidemiological studies in humans did not find the bladder cancer-inducing effects of saccharin and cyclamate that had been reported from animal studies in rats. Despite some rather unscientific assumptions, there is no evidence that aspartame is carcinogenic. Case-control studies showed an elevated relative risk of 1.3 for heavy artificial sweetener use (no specific substances specified) of >1.7 g/day. For new generation sweeteners, it is too early to establish any epidemiological evidence about possible carcinogenic risks. As many artificial sweeteners are combined in today's products, the carcinogenic risk of a single substance is difficult to assess. However, according to the current literature, the possible risk of artificial sweeteners to induce cancer seems to be negligible. (+info)Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. (6/25)
The artificial sweetener cyclamate tastes sweet to humans, but not to mice. When expressed in vitro, the human sweet receptor (a heterodimer of two taste receptor subunits: hT1R2 + hT1R3) responds to cyclamate, but the mouse receptor (mT1R2 + mT1R3) does not. Using mixed-species pairings of human and mouse sweet receptor subunits, we determined that responsiveness to cyclamate requires the human form of T1R3. Using chimeras, we determined that it is the transmembrane domain of hT1R3 that is required for the sweet receptor to respond to cyclamate. Using directed mutagenesis, we identified several amino acid residues within the transmembrane domain of T1R3 that determine differential responsiveness to cyclamate of the human versus mouse sweet receptors. Alanine-scanning mutagenesis of residues predicted to line a transmembrane domain binding pocket in hT1R3 identified six residues specifically involved in responsiveness to cyclamate. Using molecular modeling, we docked cyclamate within the transmembrane domain of T1R3. Our model predicts substantial overlap in the hT1R3 binding pockets for the agonist cyclamate and the inverse agonist lactisole. The transmembrane domain of T1R3 is likely to play a critical role in the interconversion of the sweet receptor from the ground state to the active state. (+info)Electrophysiological effects of extracellular ATP on Necturus gallbladder epithelium. (7/25)
The effects of addition of ATP to the mucosal bathing solution on transepithelial, apical, and basolateral membrane voltages and resistances in Necturus gallbladder epithelium were determined. Mucosal ATP (100 microM) caused a rapid hyperpolarization of both apical (Vmc) and basolateral (Vcs) cell membrane voltages (delta Vm = 18 +/- 1 mV), a fall in transepithelial resistance (Rt) from 142 +/- 8 to 122 +/- 7 omega.cm2, and a decrease in fractional apical membrane resistance (fRa) from 0.93 +/- 0.02 to 0.83 +/- 0.03. The rapid initial hyperpolarization of Vmc and Vcs was followed by a slower depolarization of cell membrane voltages and a lumen-negative change in transepithelial voltage (Vms). This phase also included an additional decrease in fRa. Removal of the ATP caused a further depolarization of membrane voltages followed by a hyperpolarization and then a return to control values. fRa fell to a minimum after removal of ATP and then returned to control values as the cell membrane voltages repolarized. Similar responses could be elicited by ADP but not by adenosine. The results of two-point cable experiments revealed that ATP induced an initial increase in cell membrane conductance followed by a decrease. Transient elevations of mucosal solution [K+] induced a larger depolarization of Vmc and Vcs during exposure to ATP than under control conditions. Reduction of mucosal solution [Cl-] induced a slow hyperpolarization of Vmc and Vcs before exposure to ATP and a rapid depolarization during exposure to ATP. We conclude that ATP4- is the active agent and that it causes a concentration-dependent increase in apical and basolateral membrane K+ permeability. In addition, an apical membrane electrodiffusive Cl- permeability is activated by ATP4-. (+info)Potential carcinogenicity of food additives and contaminants. (8/25)
The potential role in carcinogenesis of food additives and contaminants presents a complex problem in terms of assessing the risk to the general public. Long-term testing in laboratory animals is still the most feasible method for determining potential carcinogenicity of various chemicals. The disadvantages encountered in the present methods of animal testing are discussed and a review is made of the current status of particular food additives and contaminants under scrutiny as possible carcinogens. It is suggested that, since it may not be possible to remove all carcinogenic materials from the environment, methods to mitigate or neutralize their harmful effects should be sought. Greater cooperation is called for among food technologists, toxicologists, laboratory researchers, and epidemiologists in the decision-making process regarding the role of possibly carcinogenic additives and contaminants. (+info)Cyclamate - Regulatory Controversy, Does Cyclamate Cause Cancer? - Sweet, Saccharin, Mixture, and Bitter - JRank...
Sodium Cyclamate
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CYCLOHEXYLAMINE ( S KLOHEKS LAM N)
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Cyclamate
Cyclamates and its salts (such as calcium cyclamate, sodium cyclamate, magnesium cyclamate, and potassium cyclamate) are ... FAP 2A3672 Cyclamate (cyclamic acid, calcium cyclamate, and sodium cyclamate) Weihrauch MR, Diehl V (2004). "Artificial ... Cyclamate is approved as a sweetener in at least 130 countries. In the late 1960s, cyclamate was banned in the United Kingdom; ... As cyclamate is stable to heat, it was and is marketed as suitable for use in cooking and baking. In 1966, a study reported ...
Cyclamate sulfohydrolase
Other names in common use include cyclamate sulfamatase, cyclamate sulfamidase, and cyclohexylsulfamate sulfamidase. This ... In enzymology, a cyclamate sulfohydrolase (EC 3.10.1.2) is an enzyme that catalyzes the chemical reaction cyclohexylsulfamate ... Nimura T, Tokieda T, Yamaha T (February 1974). "Partial purification and some properties of cyclamate sulfamatase". J. Biochem ...
Diet drink
Nevertheless, cyclamate remains banned in the US. Recently, two other sweeteners have been used with increasing frequency: ... In 1970, the Food and Drug Administration banned cyclamates in the United States based on the results of a study which found ... Per the Delaney amendment, the FDA immediately announced a ban on cyclamate in food and drink products, to take effect in 1970 ... All of the above products were originally sweetened with cyclamates and saccharin, which soon proved disastrous. In 1969, an ...
Sugar substitute
Cyclamates are used outside the United States, but are prohibited from being used as a sweetener within the United States. The ... In the United States, the Food and Drug Administration banned the sale of cyclamate in 1969 after lab tests in rats involving a ... In Canada, cyclamate is used. Stein, Anne (11 May 2011). "Artificial sweeteners. What's the difference?". Chicago Tribune. ... "Worldwide status of cyclamate". Calorie Control Council. Retrieved 10 January 2018. Lyn O'Brien-Nabors (2011). Alternative ...
Timeline of United States discoveries
Kaufman, Leslie (August 21, 1999). "Michael Sveda, the Inventor Of Cyclamates, Dies at 87". Nobel The New York Times. Retrieved ...
John Mallette
He did research on cholesterol, oral contraceptives and cyclamates. He is the namesake of John Mallette Drive in Nashville, ... According to The Tennessean, he also did "pioneering research into the harmful effects of cyclamates on animals which were ...
Fizzies
At certain times it was sweetened with cyclamates and saccharin. At one point the directions instructed children to add sugar ...
Funny Face (drink mix)
The mix was sweetened with calcium cyclamate. Cyclamates and their salts (including calcium cyclamate and sodium cyclamate) ... Carlos Vincent Domingues; Alex Leybelman; Julie M. Fagan (2014). FDA's Persistent Ban on the Artificial Sweetener Cyclamate ( ... were banned in the United States in 1970; Calcium cyclamate was briefly replaced by saccharin, which proved unpopular, after ...
Iron polymaltose
Chewable tablets: cyclamate, vanillin, fersip, aromatica, excip. pro compr. Drops: conserv.: E217, E219; sucrose, vanillin, ...
Diet Rite
The original formula was sweetened with cyclamate and saccharin. After cyclamate was banned in 1969, it was removed from the ...
Fresca
... was originally sweetened with cyclamates which were banned by the FDA in 1969. They were replaced with saccharin and in ...
2005 Indonesia food scare
Benzoate and cyclamate were commonly used as food additives in Indonesia. Other substances found in the samples, such as borax ... Other food contaminants found by Depok Health agency in elementary schools in 2006 were sodium benzoate, cyclamate and borax ...
Tab (drink)
It was initially sweetened with a mixture of cyclamate and saccharin. After the Food and Drug Administration (FDA) issued a ban ... Studies on laboratory rats during the early 1970s linked high volumes of cyclamate and saccharin with the development of ... on cyclamate in 1969, sodium saccharin was used as the beverage's primary sweetener. ...
Sucralose
In Canada, yellow packets are also associated with SugarTwin's cyclamate sweetener. Citations Merck Index, 11th Edition, 8854. ...
No-Cal
This, coupled with the Food and Drug Administration's ban of cyclamate sweeteners from all U.S. food and drug products in ... Initially it came only in ginger ale, sweetened with sodium cyclamate. Later, root beer and black cherry were added, the latter ...
Herbert L. Ley Jr.
By 1969 there were $1 billion in annual sales of cyclamate. However, by that time some animal studies had shown that very high ... In October 1970, a year after Ley left, the FDA banned cyclamate completely from all food and drug products in the United ... Ley met tremendous opposition from Upjohn.: 17-19 The highest profile issue that Ley had to confront was sodium cyclamate. An ... in connection with the banning of cyclamates because he did what the Secretary told him to do (to not discuss the matter within ...
Saccharin
A 10:1 cyclamate-saccharin blend is common in countries where both these sweeteners are legal; in this blend, each sweetener ... Saccharose Sugar substitute Sodium cyclamate Sucralose Aspartame Neotame Steviol glycoside Xylitol "Saccharin". Pubchem. March ...
Sulfamic acid
Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate. Related compounds are also ...
Sweet'n Low
In Canada, Sweet'n Low is made from sodium cyclamate rather than saccharin. Although saccharin was not allowed as a food ...
Li hing mui
... as cyclamate was found being used. As the dried plum using candyleaf was developed in 1981 by such confectionaries as Uema ...
Sweetness
Saccharin, cyclamate, aspartame, acesulfame potassium, sucralose, alitame, and neotame are commonly used.[citation needed] A ...
Tongaat Hulett
... sodium cyclamate, polydextrose, maltitol and lactitol. It is the exclusive South African agent of Nutrasweet's aspartame and ...
Cyclamic acid
"Quantitative hydrolysis of sodium cyclamate and calcium cyclamate to cyclohexylamine, followed by colorimetric analysis". ... The sodium and calcium salts of cyclamic acid are used as artificial sweeteners under the name cyclamate. Johnson, Darryl E; ...
Glossary of diabetes
Cyclamate a man-made chemical used instead of sugar in low calorie foods and drinks. Banned in the US (due to concerns about ...
7 Up
... government ban of cyclamate sweetener. After reformulation, it was reintroduced as Diet 7 Up in 1970. It was renamed Sugar Free ...
Assugrin
After cyclamate was declared safe for consumption in the mid-1950s, the Hermes Company announced their new product, Assugrin, ... Cyclamate sugar substitute was discovered in 1937 by two American chemists and tested over the subsequent twenty years. ... Assugrin is a brand name for a sugar substitute that is a blend of cyclamate and saccharin. Produced in Switzerland by MCM ... More than a decade later, in 1965, Hermes company came up with a mixture of saccharin and cyclamate. It was later introduced to ...
Rivella
... Blue contains 14 grams of lactose and artificial sweeteners (cyclamate, acesulfame K) instead of refined sugar. This ...
Pillsbury (brand)
When cyclamate was banned, Sweet* 10 and Funny Face were eliminated, resulting in a $4.5 million loss. Both products were re- ... In the 1960s, Pillsbury added Sweet* 10 made with cyclamate, which became the most popular artificial sweetener. In 1964, ...
August 1970
Bars All Cyclamates After Sept. 1", Pittsburgh Press, August 14, 1970, p1 "Cyclamates: House Report Charges Administrative ... Puerto Rico had enacted a no-fault plan in 1969 All diet foods and drinks with sodium cyclamate as an artificial sweetener were ... Bottles and cans of Cyclamate-sweeted diet soft drinks had been banned since January 1, but the sweeteners were still used in ... The United States Food and Drug Administration gave retailers 18 days to sell or remove their remaining stock of the cyclamate- ...
Robert Cade
Other sweeteners were substituted in 1970, when the federal Food and Drug Administration (FDA) banned cyclamate as a potential ... the researchers added lemon juice and cyclamate to the original formula of water, salt, sodium citrate, fructose and ...
Cyclamate Definition & Meaning | Dictionary.com
Cyclamate definition, any of several chemical compounds used as a noncaloric sweetening agent in foods and beverages: banned by ... Words nearby cyclamate. cycasin, cycl-, cyclable, Cyclades, Cycladic, cyclamate, cyclamen, cyclamen aldehyde, cyclamic acid, ... cyclamate. in a sentence. *. About 30 times sweeter than sugar, cyclamate isnt metabolized, making it ideal for people who ... However, when its combined with cyclamate, the bitterness goes away.. The Rise And Fall Of Tab - After Surviving The Sweetener ...
Sodium cyclamate 139-05-9, China Sodium cyclamate 139-05-9 Manufacturers, China Sodium cyclamate 139-05-9 Suppliers -...
... provide Sodium cyclamate 139-05-9 product and the products related with China Sodium cyclamate 139-05-9 - ZhongBaoChem ... China Sodium cyclamate 139-05-9 Suppliers and China Sodium cyclamate 139-05-9 Manufacturers, ... Sodium cyclamate. Category : Food and Feed additives/Food additives. CAS NO : 139-05-9. EC NO : 205-348-9. Molecular Formula : ... Send your inquiry to Sodium cyclamate supplier. Enter your inquiry here and then click Send. Enter between 20 to 3,000 ...
Spectrophotometric determination of cyclamate in soft drinks and desserts: A complementary collaborative study - Fingerprint
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Artificial Sweeteners and Post-Meal Glucose, Hunger Hormones
Sodium Cyclamate (Swetiest) | Distributor Bahan Kimia
HES Indomakmur Gemilang - Sodium Cyclamate (Swetiest),, Sodium cyclamate (sweetener code 952) is an artificial sweetener. It is ... This entry was posted in Product and tagged Chemical Food, Food Ingredients, Industry Food, Sodium Cyclamate (Swetiest). ... Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by the ... It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin ...
IMSEAR at SEARO: Risk Assessments of Cyclamate, Saccharin, Neohesperidine DC, Steviol Glycosides and Neotamefrom Soft Drinks, ...
Risk Assessments of Cyclamate, Saccharin, Neohesperidine DC, Steviol Glycosides and Neotamefrom Soft Drinks, "Saft" and Nectar. ... Risk Assessments of Cyclamate, Saccharin, Neohesperidine DC, Steviol Glycosides and Neotamefrom Soft Drinks, "Saft" and Nectar ... VKM further concludes that among young women who are high consumers of beverages with cyclamate, and 2-year-old children who ... VKM was also requested to compare the current calculated intake of saccharin and cyclamate to the calculated intake reported by ...
Sodium Cyclamate--Arshine Food--Efficient & Professional Supplier of Food Additives
The main function of sodium cyclamate is flavoring, which can help increase the sweetness of various foods. It is often used as ... Sodium Cyclamate. CAS#139-05-9. Sodium cyclamate is a commonly used sweetener, its sweetness is 30 to 40 times that of sucrose ... Sodium cyclamate is widely used in canned fruits, jelly, cold drinks, compound seasonings, jams, preserves, cooked beans and ... The sweetness of Sodium cyclamate appears slower, but lasts for a long time, and the sweetness is relatively pure. It can be ...
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Cyclamate Market : Making Informed Business Decisions by Having Complete Insights of Market 2020 - CoinBlock.Asia - Crypto,...
Sodium cyclamates that is generally known as cyclamate is a common salt. Calcium cyclamate is used in low -sodium and sodium ... Cyclamates are of three types that include cyclamic acid, sodium cyclamate and calcium cyclamate. Cyclamic acid is a white ... In the 1950s, cyclamate was used in diet drinks. This led the cyclamate market to grow rapidly that accounted for 30% sale of ... Cyclamate is approved in more than 100 countries worldwide for use in beverages and food. Cyclamate was initially marketed as ...
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Effects of artificial sweeteners on insulin release and cationic
The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on ... Sodium saccharin (1.0-10.0 mM), sodium cyclamate (5.0-10.0 mM), stevioside (1.0 mM) and acesulfame-K (1.0-15.0 mM), all of ... The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on ...
SciELO - Public Health - Food additives in childhood: a review on consumption and health consequences Food additives in...
Sweeteners: acesulfame K, saccharin, aspartame, cyclamate and sucralose.. Consumption by 2,664 individuals aged 2 to 18 years. ... Sweeteners: acesulfame K, stevia, saccharin, aspartame, cyclamate and sucralose.. Consumption by 250 children between 6 and 12 ... Preservatives: benzoates and sorbates; Sweeteners: cyclamate and saccharin; Dyes: tartrazine and sunset yellow.. Consumption by ... Considering maximum intakes, 0.3% of children exceeded the ADI for saccharin and 0.9% for cyclamate. ...
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Texans will admit to addiction to cold sweet beverages at all meals. Deep South like Louisiana, Mississippi, Alabama, Texas, Arkansas, they almost automatically bring you sweet tea unless you specify.. I have had Texas friends stock their businesses with multiple soda machines full of THEIR favorites, a doctor who kept an ice chest full of Dr. Pepper in his Porsches trunk in case of crisis and many others who did similar "emergency" preparations. I used to pack an entire suitcase with canned Diet Coke or Tab (whichever I was drinking) and ship it on cruises, vacations to Mexico and anywhere I thought they might not have it. I took it with me when I was a floral show designer and stuck it under the design table and sucked it down for the caffeine.. When I had a REALLY tough or fast project, my helpers would pop open TWO diet sodas (see above) and tell me it was a two Coke/Tab job. I lived on them, at least a 12 pack a day or more but diet.. Never knew North Carolina was Pepsi Country until I had ...
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Removal of pharmaceutical compounds, artificial sweeteners, and perfluoroalkyl substances from water using a passive treatment...
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Consumption of non-nutritive sweeteners by pre-schoolers of the food and environment Chilean cohort (FECHIC) before the...
The highest intakes of NNS were observed for Aspartame [2.5 (1.4-3.7) mg/kg per consumer], followed by Sodium Cyclamate [1.6 ( ... Intakes and main dietary sources were described for the six most prevalent NNS in Chile: Sodium Cyclamate, Saccharin, Aspartame ... For each one of them, JECFA established the following ADIs: 0-11 mg/kg body weight/day for Sodium Cyclamate, 0-5 mg/kg body ... The highest intakes of NNS were observed for Aspartame [2.5 (1.4-3.7) mg/kg per consumer], followed by Sodium Cyclamate [1.6 ( ...
SodiumAspartameSaccharin and cyclamateSweetenersArtificial sweetenerSoft drinksBeveragesCyclohexylamine1969FoodSugarDrinksDemandStudiesSafeDietSweetenerArtificialAnalysis of the global Cyclamate marketCyclamic acidGlobal sodium cyclamateSweeteners sodium cyclamateSucroseTimes sweeter than sugarSucarylDiscovered in 1937Sweet'N LowCyclohexylamineTable-top sweetenersSaccharineBladder cancer1996IngredientsDegradationCarcinogenRatsBacteriaDrugsSyntheticIngredientMixtureForecastVitroBeverageMarket
Sodium23
- Sodium cyclamate (sweetener code 952) is an artificial sweetener. (hesig.co.id)
- Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by the sulfonation of cyclohexylamine. (hesig.co.id)
- Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in kerosene) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (hesig.co.id)
- This entry was posted in Product and tagged Chemical Food , Food Ingredients , Industry Food , Sodium Cyclamate (Swetiest) . (hesig.co.id)
- Sodium cyclamate is a commonly used sweetener, its sweetness is 30 to 40 times that of sucrose. (arshinefood.com)
- The sweetness of Sodium cyclamate appears slower, but lasts for a long time, and the sweetness is relatively pure. (arshinefood.com)
- Sodium cyclamate can also be mixed with saccharin to mask the bad taste of saccharin. (arshinefood.com)
- Last week, the EU issued a decision that extends existing anti-dumping duties on sodium cyclamate from China (and Indonesia as well). (chinatrademonitor.com)
- Cyclamates are of three types that include cyclamic acid, sodium cyclamate and calcium cyclamate. (coinblock.asia)
- Sodium cyclamate and calcium cyclamate has similar physical properties as that of cyclamic acid, which is freely soluble in water but partially soluble in benzene, chloroform and diethyl ether. (coinblock.asia)
- Sodium and calcium cyclamates are used as non-sweeteners. (coinblock.asia)
- Sodium cyclamates that is generally known as cyclamate is a common salt. (coinblock.asia)
- Calcium cyclamate is used in low -sodium and sodium free products. (coinblock.asia)
- Sodium and calcium cyclamates are produced in Western Europe, Argentina, Indonesia, Germany and Brazil. (coinblock.asia)
- Cyclamic acid is produced in Japan, Spain, Taiwan and the U.S. Due to potential health concerns, sodium cyclamate was banned in the U.S. Currently cyclamate is under reapproval due to its safe use in other countries. (coinblock.asia)
- EMAILWIRE.COM, January 03, 2017 ) In this report, we analyze the Sodium Cyclamate industry from two aspects. (emailwire.com)
- Sodium-cyclamate (139059), tryptophan (153946), and amobarbital (57432) showed ambiguous or weakly positive results. (cdc.gov)
- The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on pancreatic beta cells. (greenmedinfo.com)
- Sodium saccharin (1.0-10.0 mM), sodium cyclamate (5.0-10.0 mM), stevioside (1.0 mM) and acesulfame-K (1.0-15.0 mM), all of which display a bitter taste, augmented insulin release from islets incubated in the presence of 7.0 mM D-glucose. (greenmedinfo.com)
- 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
- Intakes and main dietary sources were described for the six most prevalent NNS in Chile: Sodium Cyclamate, Saccharin, Aspartame, Acesulfame Potassium, Sucralose, and Steviol glycosides. (biomedcentral.com)
- Fabrication du Chlorate de Soude par Electrolyse du Chlorure de Sodium avec Anodes en Graphite (Manufacturing of Soda Chlorate by Electrolysis of Sodium Chloride with Graphite Anodes). (epa.gov)
- Potential Role of Bioactivation in Tumor Promotion: Indirect Evidence from Effects of Phenol, Sodium Cyclamate and Their Metabolites on Metabolic Cooperation In vitro. (epa.gov)
Aspartame5
- Cyclamate was banned in 1969, and no other artificial sweetener would work on cereal without tasting nasty (like saccharin) until aspartame came out in the early 80s. (mrbreakfast.com)
- Demand for mature HIS-cyclamate, saccharin, and aspartame-is flat or declining in North America and Western Europe although consumption continues to increase in Asia, the Middle East, and Africa. (spglobal.com)
- Market for low-calorie foods is segmented on the basis of product types into sucralose, aspartame, stevia, saccharin, and cyclamate. (grandviewresearch.com)
- A new Nordic study shows that wastewater from sewage treatment plants contains the sweeteners aspartame, sucralose and cyclamate, and there are actually no rules on how much of these substances a plant can discharge. (sciencenordic.com)
- Aspartame, sucralose and cyclamate are synthetic substances. (sciencenordic.com)
Saccharin and cyclamate3
- VKM was also requested to compare the current calculated intake of saccharin and cyclamate to the calculated intake reported by VKM in 2007 (the VKM report «Impact on health when sugar is replaced with intense sweeteners in soft drinks, "saft" and nectar») when possible (VKM, 2007). (who.int)
- Due to possible differences in the calculation, it was not possible to compare the current calculated intake of saccharin and cyclamate to the calculated intake reported by VKM in 2007. (who.int)
- Mixture of saccharin and cyclamate that had synergistic sweetening properties and improved taste was then sold for use as special dietary food. (coinblock.asia)
Sweeteners6
- A salt or ester containing the group C 6 H 12 NO 3 S. Some cyclamates were formerly used as artificial sweeteners. (dictionary.com)
- the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (hesig.co.id)
- For all age groups in all scenarios, the intake of the sweeteners cyclamate, saccharin, neohesperidine DC, steviol glycosides and neotame was below their respective established ADI values. (who.int)
- VKM concludes that there is no major health concern related to the intake of the sweeteners cyclamate, saccharin, neohesperidine DC, steviol glycosides and neotame from the beverage categories included in this risk assessment per today. (who.int)
- Some studies show using artificial sweeteners like cyclamates in your beverages or food may increase your sensitivity to light. (life123.com)
- For example, sugar trade groups funded research that later turned out to be spurious, including studies showing that artificial sweeteners called cyclamates are unhealthy, and that people could use a vaccine to prevent cavities. (psmag.com)
Artificial sweetener1
- Albany, NY - ( SBWIRE ) - 04/17/2019 - Cyclamate, discovered in 1937 is an artificial sweetener that is approximately 30 times as sweet as sugar. (coinblock.asia)
Soft drinks2
- IMSEAR at SEARO: Risk Assessments of Cyclamate, Saccharin, Neohesperidine DC, Steviol Glycosides and Neotamefrom Soft Drinks, "Saft" and Nectar. (who.int)
- This led the cyclamate market to grow rapidly that accounted for 30% sale of soft drinks. (coinblock.asia)
Beverages5
- VKM further concludes that among young women who are high consumers of beverages with cyclamate, and 2-year-old children who are high consumers of beverages with steviol glycosides, the estimated intake approaches the ADI values. (who.int)
- Cyclamate is approved in more than 100 countries worldwide for use in beverages and food. (coinblock.asia)
- Cyclamates are primarily used in the food and beverages industry. (coinblock.asia)
- Strong demand from the food and beverages industry is expected to drive the cyclamate market worldwide. (coinblock.asia)
- By the time Dad started bringing diet beverages into the house after his surgery in 1977, cyclamate had disappeared and had been replaced by saccharin. (103gbfrocks.com)
Cyclohexylamine1
- Cyclamates are produced from cyclohexylamine that is obtained by reduction of aniline through the process of sulfonation. (coinblock.asia)
19691
- This was due to the use of Pillsbury s Sweet 10 formula, based on cyclamates, which were banned by the FDA in 1969. (wesclark.com)
Food1
- Cyclamate, a classic example, was banned for use in food in the US following studies in the 1960s showing its role in causing bladder cancer in rats. (mintel.com)
Sugar1
- About 30 times sweeter than sugar, cyclamate isn't metabolized, making it ideal for people who need to avoid sugar. (dictionary.com)
Drinks1
- In the 1950's, cyclamate was used in diet drinks. (coinblock.asia)
Demand3
- Growing pharmaceutical industry is also expected to boost demand for cyclamates in near future, given cyclamates have wide applications in pharmaceutical industry to manufacture various drugs. (coinblock.asia)
- Concerns over potential side effects of cyclamate and carcinogenic factors such as bladder cancer in humans are expected to hamper the growth of cyclamate market in the near future.Europe and Asia Pacific are expected to boost demand for cyclamate as cyclamate is consumed on a large scale in this region. (coinblock.asia)
- As cyclamate is not approved in the U.S. due to its potential health concerns, America's is anticipated to experience sluggish demand for cyclamate in the near future. (coinblock.asia)
Studies1
- See more studies on cyclamate and. (naturalnews.com)
Safe1
- Safety concerns have led to cyclamates being banned in the United States and other countries, though the European Union recognizes them as safe. (hesig.co.id)
Diet2
- When diet sodas came into popularity in the 1950s, we all began drinking cyclamate. (103gbfrocks.com)
- Nevermind a human would need to consume over 350 cans of diet soda containing cyclamate a day to expose themselves to the same risk the rats faced in their experiment to see similar effects. (mintel.com)
Sweetener12
- It is less expensive than most of the sweetener thus, there is a high demand for sodium cyclamate as it is commercially used as an artificial sweetener to improve the quality of the food & beverages products. (maximizemarketresearch.com)
- Cyclamate remains banned in the U.S. since its incarceration in the 1970s, despite being available in over 55 countries, including Canada (although only as a tabletop sweetener). (askmen.com)
- Sodium cyclamate (sweetener code 952) is an artificial sweetener. (hesig.co.id)
- In 1969, the Food and Drug Administration banned the sweetener cyclamate after lab studies indicated that large doses of the sweetener led to bladder cancer in animals. (science20.com)
- Sodium cyclamate is the sodium salt of cyclamic acid and it is an artificial sweetener 30-50 times sweeter than sucrose. (wiseguyreports.com)
- Based on animal studies, the U.S. Food and Drug Administration and other countries have banned just one type of artificial sweetener: cyclamates. (memorialhermann.org)
- It was initially developed to compensate for sugar shortages during the first world war, but took off in the 1960s when its taste was found to be improved by blending it with another artificial sweetener, cyclamate, discovered in 1937. (chemistryworld.com)
- There is a excellent precedent for this: the fact that Richard Nixon in 1969 ordered that the FDA rescind the approval for another proven carcinogenic artificial sweetener, Cyclamates. (rense.com)
- The relationship between artificial sweetener consumption and cancer risk is a controversial one, going back to the 1970s when (sweetener) cyclamate was banned for being linked to bladder cancer in rats -- although this was never shown to be the case in humans," said James Brown, a biomedical scientist at Britain's Aston University. (france24.com)
- Popular in the early 60s and banned as a food additive by 1969 the advertisement history of the no calorie, sugar free sweetener called Sucaryl (Cyclamate) was short lived. (rubylane.com)
- This SUCOFIN - Table-Top Sweetener is marketed by B& B Import (German Company).This SUCOFIN - Table-Top Sweetener 1 sweetener tablet contains 40mg of cyclamates and 4mg of saccharin's, and its sweetness is equivalent of 1 cube of sugar (4.4g). (doordelivery.pk)
- The classic KANDISIN sweetener is based on saccharin and cyclamate. (piccantino.com)
Artificial6
- Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. (nih.gov)
- While Tab contained two artificial sweeteners - saccharin and cyclamate - cyclamate was the more important of the two. (science20.com)
- Polinizacion artificial en olivo. (urv.es)
- Over the years the Delaney clause has triggered regulatory action against a number of chemicals, including food colors and the artificial sweeteners cyclamate and saccharin. (acsh.org)
- Artificial sweeteners were seen to cause cancer in rats in the past, however neither cyclamate, nor saccharin, the most commonly used artificial sweeteners are seen to cause cancer in human beings. (onlinecancerguide.com)
- Cyclamates are among the first artificial sweeteners used in diet drinks. (detox-foods.co.uk)
Analysis of the global Cyclamate market1
- The objective of the report is to present a comprehensive analysis of the global Cyclamate market including all the stakeholders of the industry. (maximizemarketresearch.com)
Cyclamic acid1
- Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by the sulfonation of cyclohexylamine. (hesig.co.id)
Global sodium cyclamate5
- By Type, in 2019, the global sodium cyclamate segment was xx% and it is estimated to reach USD$ XX Mn by 2027. (maximizemarketresearch.com)
- Kenneth Research released a report on the Global Sodium Cyclamate Market that consists of a detailed analysis and industry insights for the forecast period, i.e. 2022-2031. (techtodaynewspaper.com)
- This definitely shows how the market is trying to recover back and this will have a direct impact on the Healthcare/ICT/Chemical/Energy industries, creating a huge demand for Global Sodium Cyclamate Market products. (techtodaynewspaper.com)
- The 'Global Sodium Cyclamate Market Outlook 2018-2023' offers detailed coverage of sodium cyclamate industry and presents main market trends. (techtodaynewspaper.com)
- According to Gen Consulting Company, global sodium cyclamate market is projected to grow at a CAGR of 2.3% during the forecast period 2021-2027. (wiseguyreports.com)
Sweeteners sodium cyclamate1
- Ingredients of the prepared beverage: Water, sugar, citric acid, coloring concentrate of lemon and safflower flowers, flavoring, sweeteners sodium cyclamate and acesulfame-K, preservative potassium sorbate, acidity regulator trisodium citrate, color Food Blue-5. (germanshop24.com)
Sucrose1
- Dalderup,L.M. and Visser,W. 1971 Influence of extra sucrose, fats, protein and of c clamate in daily, fogd en life-span of rats. (nih.gov)
Times sweeter than sugar2
- About 30 times sweeter than sugar, cyclamate isn't metabolized, making it ideal for people who need to avoid sugar. (science20.com)
- Cyclamates 30 times sweeter than sugar, but some studies showed that it causes bladder cancer in animals, thus is banned in U.S. (diethealthclub.com)
Sucaryl1
- Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in kerosene) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (hesig.co.id)
Discovered in 19372
- Discovered in 1937, cyclamate was first marketed in 1949, and banned by the FDA as potentially harmful in 1970. (britannica.com)
- Kirsch wanted to create a soda for diabetics and people with cardiovascular problems, so he used cyclamate , which was discovered in 1937 by a graduate student working at a University of Illinois chemistry lab after he licked some of the substance and found that it tasted sweet. (science20.com)
Sweet'N Low1
- Cyclamates (Sugar Twin, Sweet'N Low) can be used to flavor both cold and hot beverages. (rosschocolates.ca)
Cyclohexylamine3
- Cyclamates are produced from cyclohexylamine which is obtained by the reduction of aniline by sulfonation. (maximizemarketresearch.com)
- The primary concern was that it could be toxic to some individuals who appear to metabolize cyclamate to cyclohexylamine. (classmonkeys.com)
- A plausible but alarming analogy might be drawn between cyclamate, or its conversion product, cyclohexylamine and the industrial carcinogen, 2-naphthylamine (iv). (nih.gov)
Table-top sweeteners3
- In this work, a simple method based on anthocyanins degradation by nitrite ion was used to determine cyclamate in table-top sweeteners. (edu.mx)
- The method was applied for determination of cyclamate in table-top sweeteners and the results were compared with the official method (AOAC 957.09). (edu.mx)
- Cyclamate and saccharin are sugar substitutes used in table top sweeteners. (healthlinkbc.ca)
Saccharine1
- Recherche de la saccharine, de la dulcine et du cyclamate dans le vin par chromatographie en couche mince. (urv.es)
Bladder cancer1
- No studies have appeared to date that can set an upper limit to the chronic risk of bladder cancer in man from the consumption of cyclamates. (nih.gov)
19961
- 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
Ingredients1
- This entry was posted in Product and tagged Chemical Food , Food Ingredients , Industry Food , Sodium Cyclamate (Swetiest) . (hesig.co.id)
Degradation1
- Cyclamate degradation in mammals and in vitro. (nih.gov)
Carcinogen1
- However, cyclamate-containing bacteria in the intestines may convert cyclamate to cyclohexamine, a carcinogen that may cause cancer. (maximizemarketresearch.com)
Rats1
- Back in 2000, the manufacturer of cyclamate submitted a petition for its re-approval into the U.S. on the grounds that the prior ban was due to an old study on rats from which results have not since been reproduced. (askmen.com)
Bacteria1
- Gut bacteria and the metabolism of cyclamate in the rat. (nih.gov)
Drugs1
- In addition, cyclamate is used for the manufacturing of drugs also, with the growth in the pharmaceutical industry is likely to boost the market growth. (maximizemarketresearch.com)
Synthetic1
- The observation that synthetic sweeteners (saccharin, I could find no reference to cyclamate) enhance appetite in satiated animals (Valenstein, 1967) has just begun to provoke more detailed behavioral studies. (nih.gov)
Ingredient1
- Cyclamate is an unapproved ingredient. (fda.gov)
Mixture1
- the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (hesig.co.id)
Forecast2
- Global Cyclamate Market is expected to grow at a CAGR of 4.7% during the forecast period. (maximizemarketresearch.com)
- The market research gives historical and forecast market size, demand, end-use details, price trends, and company shares of the leading sodium cyclamate producers to provide exhaustive coverage of the market for sodium cyclamate. (techtodaynewspaper.com)
Vitro1
- Potential Role of Bioactivation in Tumor Promotion: Indirect Evidence from Effects of Phenol, Sodium Cyclamate and Their Metabolites on Metabolic Cooperation In vitro. (epa.gov)
Beverage1
- Forty-nine women consumed a beverage containing 60 mg of cyclamate. (nih.gov)
Market3
- Global Cyclamate Market is expected to reach US$ 390.31 Mn by2027. (maximizemarketresearch.com)
- Consumer awareness towards health and increasing patients of diabetic patients has led to increasing demand for the cyclamate market. (maximizemarketresearch.com)
- The report also helps in understanding global Cyclamate market dynamics, structure by analyzing the market segments and project global Cyclamate market clear representation of competitive analysis of key players by price, financial position, by detection and equipment portfolio, growth strategies, and regional presence in the global Cyclamate market make the report investor's guide. (maximizemarketresearch.com)
