Curcumin
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells. (1/1291)
Curcumin, the yellow pigment of turmeric (Curcuma longa), used commonly as a spice, has been shown to possess anticarcinogenic activity. Curcumin inhibited AK-5 tumor growth and induced apoptosis in AK-5 cells. Curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide Ac-DEVD-CHO. In addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by N-acetyl-L-cysteine. Our studies suggest that the apoptotic process induced by curcumin is the mechanism mediating AK-5 tumor cell death. (+info)Biotransformation of curcumin through reduction and glucuronidation in mice. (2/1291)
Curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. In this study, we investigated the pharmacokinetic properties of curcumin in mice. After i.p. administration of curcumin (0.1 g/kg) to mice, about 2.25 microg/ml of curcumin appeared in the plasma in the first 15 min. One hour after administration, the levels of curcumin in the intestines, spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g, respectively. Only traces (0.41 microg/g) were observed in the brain at 1 h. To clarify the nature of the metabolites of curcumin, the plasma was analyzed by reversed-phase HPLC, and two putative conjugates were observed. Treatment of the plasma with beta-glucuronidase resulted in a decrease in the concentrations of these two putative conjugates and the concomitant appearance of tetrahydrocurcumin (THC) and curcumin, respectively. To investigate the nature of these glucuronide conjugates in vivo, the plasma was analyzed by electrospray. The chemical structures of these metabolites, determined by mass spectrometry/mass spectrometry analysis, suggested that curcumin was first biotransformed to dihydrocurcumin and THC and that these compounds subsequently were converted to monoglucuronide conjugates. Because THC is one of the major metabolites of curcumin, we studied its stability at different pH values. THC was very stable in 0.1 M phosphate buffers of various pH values. Moreover, THC was more stable than curcumin in 0.1 M phosphate buffer, pH 7.2 (37 degrees C). These results, together with previous findings, suggest that curcumin-glucuronoside, dihydrocurcumin-glucuronoside, THC-glucuronoside, and THC are major metabolites of curcumin in vivo. (+info)The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. (3/1291)
BACKGROUND: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder. AIMS: To compare the effect of 20 mg curcumin or placebo on the gall-bladder volume of healthy volunteers. METHODS: A randomized, double blind and crossover design study was carried out in 12 healthy volunteers (seven males and five females). Ultrasonography examination was carried out serially to measure the gall-bladder volume. The data obtained was analysed by paired Student's t-test. RESULTS: The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P > 0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo. CONCLUSION: On the basis of the present findings, it appears that curcumin induces contraction of the human gall-bladder. (+info)Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. (4/1291)
We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7). Treatment with curcumin suppressed CD- and PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2. Curcumin also suppressed the induction of COX-2 mRNA by CD and PMA. Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with CD or PMA and these effects were inhibited by curcumin. Treatment with CD or PMA increased binding of AP-1 to DNA. This effect was also blocked by curcumin. In addition to the above effects on gene expression, we found that curcumin directly inhibited the activity of COX-2. These data provide new insights into the anticancer properties of curcumin. (+info)Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. (5/1291)
Inducible nitric oxide synthase (iNOS) is overexpressed in colonic tumors of humans and also in rats treated with a colon carcinogen. iNOS appear to regulate cyclooxygenase-2 (COX-2) expression and production of proinflammatory prostaglandins, which are known to play a key role in colon tumor development. Experiments were designed to study the inhibitory effects of S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT) a selective iNOS-specific inhibitor, measured against formation of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF). Beginning at 5 weeks of age, male F344 rats were fed experimental diets containing 0 or 50 p.p.m. of PBIT, or 2000 p.p.m. of curcumin (non-specific iNOS inhibitor). One week later, rats were injected s.c. with AOM (15 mg/kg body wt, once weekly for 2 weeks). At 17 weeks of age, all rats were killed, colons were evaluated for ACF formation and colonic mucosa was assayed for isoforms of COX and NOS activities. Both COX and iNOS activities in colonic mucosa of the AOM-treated rats were significantly induced. Importantly, 50 p.p.m. PBIT suppressed AOM-induced colonic ACF formation to 58% (P < 0.0001) and crypt multiplicity containing four or more crypts per focus to 78% (P < 0.0001); it also suppressed AOM-induced iNOS activity. Curcumin inhibited colonic ACF formation by 45% (P < 0.001). These observations suggest that iNOS may play a key regulatory role in colon carcinogenesis. Developing iNOS-specific inhibitors may provide a selective and safe chemopreventive strategy for colon cancer treatment. (+info)Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. (6/1291)
A series of naturally occurring as well as synthetic structural analogs of the dietary constituent curcumin were examined in order to elucidate which portions of the molecule are critical for the ability to induce Phase 2 detoxification enzymes in murine hepatoma cells, and hence to assess the chemoprotective potential of these compounds. Two groups of compounds were studied: classical Michael reaction acceptors such as curcumin and related beta-diketones such as dibenzoylmethane which lack direct Michael reactivity. The presence of two structural elements was found to be required for high inducer potency: (i) hydroxyl groups at ortho-position on the aromatic rings and (ii) the beta-diketone functionality. All curcuminoids elevate the specific activity of quinone reductase in both wild type and mutant cells defective in either the aryl hydrocarbon (Ah) receptor or cytochrome P4501A1 activity. This indicates that neither binding to this receptor, nor metabolic activation by P4501A1 are required for the signaling process originating from this family of electrophiles and ultimately resulting in Phase 2 enzyme induction. (+info)Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. (7/1291)
We have evaluated the chemopreventive effects of curcumin on diethylstilbestrol (DES)-induced tumor promotion of rat mammary glands initiated with radiation. Sixty-four pregnant rats received whole body irradiation with 2.6 Gy gamma-rays from a 60Co source at day 20 of pregnancy and were divided into two groups after weaning. In the control group of 39 rats fed a basal diet and then implanted with a DES pellet for 1 year, 33 (84.6%) developed mammary tumors. Twenty-five rats were fed diet containing 1% curcumin immediately after weaning and received a DES pellet, as for the control. The administration of dietary curcumin significantly reduced the incidence (28.0%) of mammary tumors. Multiplicity and Iball's index of mammary tumors were also decreased by curcumin. Rats fed the curcumin diet showed a reduced incidence of the development of both mammary adenocarcinoma and ER(+)PgR(+) tumors in comparison with the control group. On long-term treatment with curcumin, body weight and ovarian weight were reduced, but liver weight was increased. Compared with the control rats, the curcumin-fed rats showed a significant reduction in serum prolactin, whereas estradiol-17beta and progesterone concentrations were not significantly different between the two groups. Curcumin did not have any effect on the concentration of free cholesterol, cholesterol ester and triglyceride. Feeding of the curcumin diet caused a significant increase in the concentrations of tetrahydrocurcumin, arachidonic acid and eicosapentaenoic acid and a significant decrease in thiobarbituric acid-reactive substance concentration in serum. Whole mounts of the mammary glands showed that curcumin yielded morphologically indistinguishable proliferation and differentiation from the glands of the control rats. These findings suggest that curcumin has a potent preventive activity during the DES-dependent promotion stage of radiation-induced mammary tumorigenesis. (+info)Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. (8/1291)
Curcumin, a natural compound present in turmeric, possessing both anti-inflammatory and antioxidant effects, has been studied vigorously as a chemopreventative in several cancer models. The erbB2/neu gene-encoded p185neu tyrosine kinase is a potent oncoprotein. Overexpression of p185neu in breast cancer is known to be a poor prognostic factor. We investigated the effect of curcumin on p185neu tyrosine kinase and on the growth of breast cancer cell lines. Curcumin dose-dependently inhibited p185neu autophosphorylation and transphosphorylation in vitro and depleted p185neu protein in vivo. It dissociated the binding of p185neu with GRP94 (glucose-regulated protein), a molecular chaperone, and enhanced the depletion of p185neu. The amount of p185neu protein on the cell membrane was drastically decreased after curcumin treatment. These data demonstrated a new mechanism of the anti-tyrosine kinase activity of curcumin. The growth of several breast cancer cell lines was inhibited; the IC50 ranged from 7 to 18 microM, which, however, did not correlate with the expression level of p185neu. Colony formation in the soft agar assay, a hallmark of the transformation phenotype, was preferentially suppressed in p185neu-overexpressing cell lines by 5 microM curcumin (% of control, basal level versus overexpression: 59.3 versus 16.7%; P < 0.001 by Student's t test). Because curcumin effectively inhibited p185neu tyrosine kinase activity by depleting p185neu and potently suppressed the growth of multiple breast cancer cell lines, its therapeutic potential in advanced breast cancer is worthy of further investigation. (+info)
Curcumin
Very little curcumin escapes the GI tract and most is excreted in feces unchanged. If curcumin enters plasma in reasonable ... Hsu, Chih-Hung; Cheng, Ann-Lii (2007). "Clinical Studies with Curcumin". The Molecular Targets and Therapeutic Uses of Curcumin ... curcumin is poorly soluble in water. However, it is easily soluble in organic solvents. Curcumin is used as a complexometric ... and no support has been found for curcumin as a medical treatment. Curcumin has been identified by the U.S. Food and Drug ...
Curcumin synthase
... may also protect Curcuma longa from herbivores to some degree, as curcumin has a distinctively bitter taste: ... Curcumin is a potent antioxidant, as its phenolic structure, highest in activity in curcumin rather than its demethoxylated ... Curcumin syntheses in C. longa have been until recently, the only readily available synthesis method of curcumin. Today, ... CURS2 produces both curcumin and demethoxycurcumin, favoring feruloyl-CoA as a starter, and CURS3 produces curcumin, ...
Turmeric
... curcumin. Turmeric powder has a warm, bitter, black pepper-like flavor and earthy, mustard-like aroma. Curcumin, a bright ... Turmeric and curcumin have been studied in numerous clinical trials for various human diseases and conditions, with no high- ... Curcumin constitutes up to 3.14% of assayed commercial samples of turmeric powder (the average was 1.51%); curry powder ... 2021). "Effects of curcumin supplementation on sport and physical exercise: a systematic review". Critical Reviews in Food ...
Ganugupahad
"turmeric curcumin". Wednesday, 11 January 2017 (Use dmy dates from November 2018, Use Indian English from November 2018, All ...
Lipofuscin
Shen, Li-Rong; Parnell, Laurence D.; Ordovas, Jose M.; Lai, Chao-Qiang (January 2013). "Curcumin and aging". BioFactors. 39 (1 ... Other possible treatments: Centrophenoxine Acetyl-L-carnitine Ginkgo biloba Dimethylethanolamine Curcumin Wet macular ...
Traditional Chinese medicine
Most of its effects have been attributed to curcumin. Research that curcumin shows strong anti-inflammatory and antioxidant ... Gautam, Subhash C.; Gao, Xiaohua; Dulchavsky, Scott (2007). "Immunomodulation by Curcumin". The Molecular Targets and ... Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 595. pp. 321-341. doi: ...
Govindarajan Padmanaban
His team was successful in showing the antimalarial property of Curcumin and its efficacy in combination therapy in 2004. ... "Curcumin for malaria therapy". Biochemical and Biophysical Research Communications. 326 (2): 472-4. doi:10.1016/j.bbrc.2004.11. ...
Derek Lowe (chemist)
Lowe, Derek (12 January 2017). "Curcumin Will Waste Your Time". In the Pipeline. Archived from the original on 6 April 2019. ...
Curcuminoid
Pure chemicals of curcumin and its derivatives are not available in the open market. Commercially available curcumin contains ... Curcumin is mainly produced in industry as a pigment by using turmeric oleoresin as the starting material which curcuminoids ... Curcumin, which shows positive results in most drug discovery assays, is regarded as a false lead that medicinal chemists ... Curcumin is obtained from the root of turmeric. Curcuminoids are soluble in dimethyl sulfoxide (DMSO), acetone and ethanol, but ...
Desmethoxycurcumin
Commercial grade curcumin contains a mixture of curcuminoids (desmethoxycurcumin 10-20%, bisdesmethoxycurcumin 5% or less). Bis ... Curcumin Sotanaphun, U.; Phattanawasin, P.; Sriphong, L. (2009). "Application of Scion image software to the simultaneous ...
Medicinal plants
1-5. Aggarwal, B. B.; Sundaram, C.; Malani, N.; Ichikawa, H. (2007). Curcumin: the Indian solid gold. Advances in Experimental ... Some important phytochemicals, including curcumin, epigallocatechin gallate, genistein and resveratrol are pan-assay ... which contains curcumin. The Chinese pharmacopoeia, the Shennong Ben Cao Jing records plant medicines such as chaulmoogra for ...
EF-24
... is a compound that is a synthetic analogue of curcumin, a bioactive phytochemical from turmeric. Curcumin has antioxidant ... EF-24 was developed to try to improve upon these properties, and has been found to be around 10x more potent than curcumin and ... He Y, Li W, Hu G, Sun H, Kong Q (2018). "Bioactivities of EF24, a Novel Curcumin Analog: A Review". Frontiers in Oncology. 8: ... Li W, He Y, Zhang R, Zheng G, Zhou D (January 2019). "The curcumin analog EF24 is a novel senolytic agent". Aging. 11 (2): 771- ...
History of herbalism
ISBN 978-0-323-02998-8. Aggarwal, Bharat B.; Sundaram, Chitra; Malani, Nikita; Ichikawa, Haruyo (2007). "Curcumin: The Indian ... Solid Gold". The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine ...
Miriam Rossi (chemist)
Rossi identified the bioactivity of curcumin. At Vassar College, Rossi supervised Cathy Drennan, and has continued to act as ... She has investigated several biological molecules, including quercetin, curcumin and resveratrol. ...
Dibenzoylmethane
It is also found in Curcumin. These occurrences have led to investigations into the medicinal properties of this class of ...
Rubrocurcumin
... is a red-colored dye that is formed by the reaction of curcumin and borates. The reaction of curcumin with ... Spicer, G. S.; Strickland, J. D. H. (1952). "Compounds of Curcumin and Boric Acid. Part II. The Structure of Rubrocurcumin". ... In rubrocurcumin, one molecule of curcumin is replaced with oxalate compared to rosocyanine. Complexes with boron such as ...
List of 5α-reductase inhibitors
Curcumin, the principal curcuminoid of turmeric. Dodder (Cuscuta reflexa) Eastern arborvitae, northern whitecedar (Thuja ... "Inhibitory Effect of Curcumin on Testosterone Induced Benign Prostatic Hyperplasia Rat Model". BMC Complementary and ... "Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors". Medicinal Chemistry Research. 26 (7): 1550-1556. ... curcumin, and myristoleic acid". Archives of Dermatological Research. 293 (4): 200-5. doi:10.1007/s004030000203. PMID 11380153 ...
Turmerone
Obulesu, Magisetty (2021). "Health benefits of turmeric: Emphasis on anticancer activity". Turmeric and Curcumin for ...
Traumatic brain injury
Liu Y, Dargusch R, Maher P, Schubert D (May 2008). "A broadly neuroprotective derivative of curcumin". Journal of ...
Alternative cancer treatments
Curcumin is a component of turmeric. It is under preliminary research for therapeutic potential but according to Cancer ...
Monoamine oxidase inhibitor
Naturally occurring RIMAs in plants Curcumin (selectivity for MAO-A and reliability of research on curcumin are disputed) ... Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA (March 2017). "The Essential Medicinal Chemistry of Curcumin". ... Kulkarni SK, Bhutani MK, Bishnoi M (December 2008). "Antidepressant activity of curcumin: involvement of serotonin and dopamine ...
Drug discovery
Baker M (9 January 2017). "Deceptive curcumin offers cautionary tale for chemists". Nature. 541 (7636): 144-145. doi:10.1038/ ...
Reagent
Many natural products, such as curcumin, are hits in almost any assay in which they are tested, are not useful tool compounds, ... Baker, Monya (9 January 2017). "Deceptive curcumin offers cautionary tale for chemists". Nature. 541 (7636): 144-145. Bibcode: ...
List of phytochemicals in food
Pinosylvin Curcumin (Oxidizes to vanillin) turmeric, mustard. Ellagitannins Punicalagins tea, berries. Castalagins Vescalagins ...
Nutritional immunology
It was demonstrated that curcumin can modulate immunity in many ways, mainly via regulation and inhibition of transcription ... "Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?: ... Immunomodulatory and anti-inflammatory effects of curcumin". Journal of Cellular Physiology. 233 (2): 830-848. doi:10.1002/jcp. ...
GSK-3
Curcumin also has chemo preventative and anti-cancer effects.[citation not found], and it has been shown to attenuate oxidative ... Curcumin, which Is a constituent of turmeric spice, has flavoring and coloring properties. It has two symmetrical forms: enol ( ... Curcumin's mechanism of action is anti-inflammatory; it inhibits the nuclear transcriptional activator kappa B (NF-KB) that is ... February 2005). "Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo ...
Zingiberaceae
"Turmeric and curcumin: Biological actions and medicinal applications". Current Science. 87 (1): 44-53. JSTOR 24107978. Sass et ...
Bisdemethoxycurcumin
Curcumin Desmethoxycurcumin T. K. Lim (11 February 2016). Edible Medicinal and Non-Medicinal Plants: Volume 12 Modified Stems, ... Bisdemethoxycurcumin is a curcuminoid found (along with the curcuminoids curcumin and demethoxycurcumin) in turmeric (Curcuma ...
Avadhesha Surolia
Curcumin and its designed analogs are being developed as experimental therapeutics for these diseases and cancer. His findings ... Mishra S, Karmodiya K, Surolia N; Surolia A (2008). "Synthesis and exploration of novel curcumin analogues as anti-malarial ... He has demonstrated the potential of common dietary components - curcumin and green tea catechins as anti-cancer and ... "Curcumin recognizes a unique binding site of tubulin". Journal of Medicinal Chemistry. 54 (18): 6183-6196. doi:10.1021/ ...
Ulcerative colitis
The effect of curcumin therapy alone on quiescent ulcerative colitis is unknown. Treatments using cannabis or cannabis oil are ... Curcumin (turmeric) therapy, in conjunction with taking the medications mesalamine or sulfasalazine, may be effective and safe ... Kumar S, Ahuja V, Sankar MJ, Kumar A, Moss AC (October 2012). "Curcumin for maintenance of remission in ulcerative colitis". ... December 2006). "Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled ...
Verdure Sciences self-affirms GRAS status for Longvida curcumin
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Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway
LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells. ... Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway. *Download PDF Copy ... Tags: Aging, Cancer, Cell, Cell Death, Colon Cancer, Colorectal, Colorectal Cancer, Curcumin, Gene, Metastasis, MicroRNA, ... With curcumin, weve found a substance with which we could intervene in the signal cascade beneath p53 by activating miR-34, ...
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Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat
Bioavailability is enhanced with a curcumin-phosphatidylcholine complex. ... To study pharmacokinetic properties of curcumin, a fast sensitive assay method was developed to determine curcumin and its ... Substances : Curcumin : CK(5598) : AC(2788), Phosphatidylcholine : CK(112) : AC(24). Additional Keywords : Bioavailability : CK ... Complex formation resulted in an obvious increase in bioavailability of curcumin in rat in vivo according to the assay by above ...
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Turmeric Curcumin Science (Updated 2023)
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Discovering Curcumin's Brain Benefits - - Life Extension
Curcumin has been shown to boost a signaling factor that is vital to retaining cognitive skills. ... New research findings show that curcumin can reduce anxiety and depression. ... Clues as to why curcumin was so effective can be found in an earlier study in which taking just 80 mg of curcumin per day for ... Curcumin is well known for its anti-inflammatory and oxidative stress-fighting properties.22 More recently, curcumin has been ...
Molecules | Free Full-Text | ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in...
Newer curcumin derivatives are being explored to overcome limitations of curcumin like low bioavailability, stability, and side ... Results: ST09 shows an approximate 100-fold higher potency than curcumin, its parent compound, on breast tumor cell lines MCF-7 ... In this study, the synthesis of ST09, a novel curcumin derivative, and its antiproliferative, cytotoxic, and migrastatic ... Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. ...
Curcumin isn't anticatabolic at all it's anabolic
But if this animal study confirms that curcumin really has anabolic qualities, we wont be complaining. ... Curcumin is perhaps the most interesting supplement being written about by scientists right now. True, hardly any research has ... Curcumin inhibits conversion of amino acids into glucose 05.05.2011. Curcumins modest kidney-stone factor 26.03.2011. Curcumin ... So curcumins mechanism is not the usual anticatabolic one. The figure above shows how it apparently does work: curcumin boosts ...
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New Curcumin Extract Found to Counteract Inflammation at the Genetic Level | Press Releases
New Curcumin Extract Found to Counteract Inflammation at the Genetic Level ... New Curcumin Extract Found to Counteract Inflammation at the Genetic Level Details TotalHealth Editors ... Elevated levels of BDMC to 30 per cent is showing dramatic results in the enhancing the efficacy of curcumins anti- ... Cavaleris research has proven for the first time how the modified curcumin extract targets and neutralizes a key protein ...
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. | Scholars@Duke
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. ... ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate ... Curcumin, a known antagonist of TNFα in multiple cell types and tissues, was chemically modified and conjugated to a thermally ... When injected proximal to the sciatic nerve in mice via intramuscular (i.m.) injection, ELP-curcumin conjugates underwent a ...
Curcumin inhibits HATs and related gene expression in the neuropathic pain
Researchers have found that using the HAT inhibitor curcumin in rat model of neuropathic pain prevents the activity regulated ... Interestingly, the group also observed a similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord after curcumin ... A research team from China investigated how curcumin works to treat neuropathic pain, and found that it prevents the activity ... Delving into the epigenome, ChIP analysis revealed that curcumin works in a dose-dependent manner to reduce the recruitment the ...
Anti-inflammatory Properties of Curcumin May Be Useful for Treating the Deleterious Effects of CCL4 on Liver and Spleen
The CCL4-curcumin group, intraperitoneally injected with CCL4 (0.1 mL kg 1) and curcumin (200 mg kg 1) was intragastrically ... The third group (CCL4-curcumin group) intragastrically received curcumin (200 mg kg 1) prior 3 days of CCL4 treatment. ... Effect of CCL4 and curcumin on IL-1, IL-6 and TNF-α mRNA expression, measured using real time PCR in BALB/c mice liver. Data ... Effect of CCL4 and curcumin on IL-1, IL-6 and TNF-α mRNA expression, measured using real time PCR in BALB/c mice spleen. Data ...
Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA...
Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell ... Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/beta-catenin negative feedback loop. Stem cell ... Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species. BMC cancer. ... curcumin inhibits EMT and migration of breast CSCs by promoting the E-cadherin/β-catenin negative feedback loop [13]. Curcumin ...
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The result of this clinical trial is also a good confirmation of systemic effect of Curcumin C3 Complex®. ... This study investigated the lipid lowering activity of curcumin in obese individuals. Thirty participants received curcuminoids ... Serum triglycerides were significantly reduced following curcumin supplementation (first period 105.7 -, 95.1 mg/dL, and second ... reported that Sabinsas Curcumin C3 Complex® led to a significant reduction in serum triglycerides concentration in a ...
CURCUMIN ADMINISTRATION ACCELERATES WOUND REPAIR AND REGENERATION IN THE EXCISION WOUND OF MICE EXPOSED TO DIFFERENT DOSES OF...
... whereas curcumin pretreatment inhibited this decline significantly. Our study demonstrates that curcumin pretreatment ... CURCUMIN ADMINISTRATION ACCELERATES WOUND REPAIR AND REGENERATION IN THE EXCISION WOUND OF MICE EXPOSED TO DIFFERENT DOSES OF ... Curcumin or diferuloylmethane is an active principle present in the turmeric, which gives a characteristic flavor and yellow ... whereas curcumin administration prior to fractionated irradiation resulted in a significant rise in the wound contraction and ...
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Vimerson Health Turmeric Curcumin may help increase your joints lubrication to assist with a smoother joint functionbility*; It ... Turmeric Curcumin with Bioperine Joint Pain Relief. Anti-Inflammatory, Antioxidant Supplement with 10 milligrams of Black ... COMMON NAMES: There are many different ways people try to spell or pronounce Turmeric Curcumin; Here are some common ... WHY CHOOSE US: Discomfort in your joints? Vimerson Health Turmeric Curcumin may help increase your joints lubrication to assist ...
Natural remedies for Crohn's: Supplements, oils, and more
Curcumin. According to research, curcumin, which is the active ingredient in turmeric, may help reduce inflammation. ... Researchers found that more than half of those taking curcumin were in remission by 4 weeks, compared with none in the control ... Lang, A., et al. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative ... Researchers compared the results from the participants taking curcumin capsules and mesalamine, which helps reduce inflammation ...
Curcumin | Diabetes Relief
CURCUMIN: 8 Reasons to Use It. Sep 19, 2018 , Everyday Wellness. We at Diabetes Relief are helping our patients to maximize the ... Here we share eight reasons to use curcumin, from www.greenmedinfo.com, a fantastic site of Dr. Sayer Ji, from an article by ... In prior newsletters we have told you of the benefits of curcumin, the source of turmeric, one of the most-studied natural ...
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Active ingredient in turmericShown that curcuminCurcumaSupplementationEffects of curcuminSuggest that curcuminTurmeric and curcuminProperties of curcuminBioavailability of curcuminDietaryCurcuminoidsDiferuloylmethaneRegular curcuminBioperineOxidative stress1,000 mgPathwaysVitroTherapeuticOleoresinDemethoxycurcumin2023AntioxidantExtractExtractsSignaling pathwayMiceBoostsNatural pigmentMechanismColorectal cancerConcentrationsInflammation2019BDNFInduceDerivativeSupplementsCapsulesComplexEfficacyInflammatoryProteinSignificantly reducedSpecificallyTumorAnticancerRatsResearchersFindingsHealth supplementAnabolicVascularCognitiveFoundProminent
Active ingredient in turmeric3
- The active ingredient in turmeric is curcumin . (solgar.com)
- Numerous studies have shown that curcumin, the active ingredient in turmeric, has positive effects on many parts of the body, including the digestive system, joints, brain, and organs. (adustyframe.com)
- Curcumin is the primary active ingredient in turmeric. (ironmagazine.com)
Shown that curcumin4
- Animal studies going back nearly five years have shown that curcumin supplementation reduces depressive-like behaviors in established models of depression. (lifeextension.com)
- In addition to these clinical benefits, research has shown that curcumin influences several salivary, urinary, and blood biomarkers of oxidative stress and inflammation. (lifeextension.com)
- Our previous studies have shown that curcumin could enhance radiosensitization in NPC by variant pathways through the regulation of different coding- or noncoding-RNAs [ 9 ]. (jcancer.org)
- Current studies have shown that curcumin exerts prominent inhibitory effects on various cancer stem cells through different pathways. (jcancer.org)
Curcuma8
- High Quality Curcumin extract Powder Product Name: Curcumin extract Other Name: Turmeric yellow, Diferuloylmethane Botanical Origin : Curcuma longa L. Appearance: Yellow to orange powder. (21food.com)
- 1: Specialized manfacturer 2: R&D team and cooperates closely 3: Free Sample available for your test Product detail showing English name: Curcumin Extract Latin name: Curcuma longa Linn Orginal p. (21food.com)
- 1.Curcuma Extract 2.Curcumin 90%,95% 3.GMP&BV Certificates 4.Free sample about 10g 5.MOQ:1KG GMP Certified Manufacturer High Quality Curcumin Extract Details: 1.Product Name Curcuma Extract 2.Lat. (21food.com)
- curcuma longa extract supplier from India Curcumin Extract 95% Features:- 1.High Quality Product 2.Made from Natural Source. (21food.com)
- curcuma longa extract supplier from India TURMERIC, CURCUMIN EXTRACT BENEFITS Turmeric herb (Curcuma longa) is a plant nat. (21food.com)
- Full Spectrum Curcumin (Polysorbate 80 (emulsifier), Turmeric Extract (Curcuma longa) [rhizome]), Vegetable Cellulose. (solgar.com)
- Enhansa is a proprietary blend of curcuminoids derived from the rhizomes of Curcuma longa (Curcumin). (ageofautism.com)
- Curcumin (CUR), a natural bioactive compound extracted from a traditional Chinese medicinal herb turmeric ( Curcuma longa ), has been reported to exhibit potent antitumor activities against different types of cancer, including NPC in both in vivo and in vitro models [ 8 ]. (jcancer.org)
Supplementation3
- The figure below shows that exercise increased carotid arterial compliance, and that curcumin supplementation boosted this effect significantly. (ironmagazine.com)
- Interestingly, curcumin supplementation of CCL 4 treated group decreased expression of inflammatory markers as well as improved antioxidant status and histoarchitecture in liver and spleen. (scialert.net)
- A placebo-controlled, randomized double-blind clinical trial published in Phytotherapy Research titled Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial (Mohammadi et al, 2012) reported that Sabinsa's Curcumin C 3 Complex ® led to a significant reduction in serum triglycerides concentration in a randomized crossover clinical trial. (sabinsa.com)
Effects of curcumin2
- We will test the hypothesis that the products of oxidative transformation are mediators of pharmacological effects of curcumin. (nih.gov)
- We investigated the effects of curcumin ingestion and aerobic exercise training on flow-mediated dilation as an indicator endothelial function in postmenopausal women. (ironmagazine.com)
Suggest that curcumin2
- Small clinical studies suggest that curcumin from turmeric is helpful for indigestion, ulcerative colitis, certain liver conditions such as non-alcoholic fatty liver disease (NAFLD), rheumatoid arthritis and osteoarthritis, seasonal allergies, as well as depression, and may have benefit in some precancerous conditions. (consumerlab.com)
- These observations suggest that curcumin may improve muscle recovery and differentiation/regeneration processes. (ergo-log.com)
Turmeric and curcumin4
- Find the Best Turmeric and Curcumin Supplements & Spices. (consumerlab.com)
- What are turmeric and curcumin? (consumerlab.com)
- Turmeric and curcumin are not well absorbed on their own and it's generally best to take turmeric/curcumin with food containing some fat in order to increase absorption. (consumerlab.com)
- Despite being a crucial element in boosting overall health, turmeric and curcumin may not easily absorb into the body better than other plant-based extracts. (adustyframe.com)
Properties of curcumin2
- To study pharmacokinetic properties of curcumin, a fast sensitive assay method was developed to determine curcumin and its metabolite tetrahydrocurcumin in rat plasma. (greenmedinfo.com)
- Cavaleri's research has proven for the first time how the modified curcumin extract targets and neutralizes a key protein central in the regulation of inflammation, while significantly enhancing the efficacy of the anti-inflammatory properties of curcumin. (totalhealthmagazine.com)
Bioavailability of curcumin2
- Complex formation resulted in an obvious increase in bioavailability of curcumin in rat in vivo according to the assay by above LC/MS/MS method. (greenmedinfo.com)
- In counterbalance, the high metabolic instability and poor systemic bioavailability of curcumin limit its therapeutic efficacy in human. (nih.gov)
Dietary5
- Curcumin is one of several curcuminoid compounds found in turmeric that give turmeric its color and antioxidant and anti-inflammatory properties, making turmeric root powders and extracts useful as dietary supplements (see What It Is ). (consumerlab.com)
- Turmeric Curcumin Plus is an organic dietary supplement designed to support the health of joints and muscles, improve the conditions of the immune system, and relieve varying degrees of discomfort and pain with antioxidant and anti-inflammatory properties. (adustyframe.com)
- The purpose of this study was to examine the antioxidant, anti-inflammatory and anti-amyloidogenic properties of dietary curcumin, and its metabolite tetrahydrocurcumin (TC). (nih.gov)
- and 3) to understand how these stem cell regulating pathways may be regulated by dietary components, including curcumin and sulforaphane. (nih.gov)
- We demonstrate here that curcumin (diferuloylmethane), a dietary polyphenol, at nanomolar concentrations specifically restores cigarette smoke extract (CSE)- or oxidative stress-impaired HDAC2 activity and corticosteroid efficacy in vitro with an EC(50) of approximately 30 nM and 200 nM, respectively. (nih.gov)
Curcuminoids5
- The typical daily dose ranges from 500 mg to 2,000 mg of curcuminoids (most of which is curcumin) from turmeric extracts (see Dosage ), which can often be as much as 95% curcuminoids. (consumerlab.com)
- Turmeric spice powder is much less concentrated - only about 3% curcuminoids- yet some turmeric supplements are just turmeric spice placed in capsules, offering much lower amounts of curcumin than supplements made from turmeric extracts. (consumerlab.com)
- Among supplements that passed testing, we identified our Top Pick -- which provided curcumin at one of the lowest costs and includes a bioavailability enhancer to boost the amount of curcuminoids making it into your bloodstream. (consumerlab.com)
- Curcumin 95 is a concentrate of 95% curcuminoids, which are powerful antioxidants found in the spice turmeric root. (needs.com)
- It is the specific ratio of curcuminoids, along with the specialized method of extraction, which allows for the unique benefits of Enhansa as compared to other Curcumin products. (ageofautism.com)
Diferuloylmethane1
- Curcumin or diferuloylmethane is an active principle present in the turmeric, which gives a characteristic flavor and yellow color to different cuisines. (hilarispublisher.com)
Regular curcumin3
- Superior absorption versus regular curcumin! (solgar.com)
- According to the manufacturer the body absorbs this form of curcumin better than regular curcumin. (ironmagazine.com)
- Regular curcumin ingestion and aerobic exercise may be effective lifestyle modifications for minimizing and reversing the loss of carotid arterial compliance with advancing age in women. (ironmagazine.com)
Bioperine3
- If you can't always take turmeric or curcumin with food, see Absorption and Bioavailability to learn about bioavailability enhancement with ingredients such as BCM-95, C3 (which includes the black pepper extract, piperine, branded as Bioperine), CurcuWin, Longvida, Meriva, NovaSol, and Theracurmin. (consumerlab.com)
- Its formulation contains an impressive blend of these high-quality ingredients: turmeric extract, its active ingredient curcumin, and the highly acclaimed BioPerine(r) compound. (adustyframe.com)
- At the same 1,000 mg /day dose, curcumin enhanced with bioperine reduced the symptoms of anxiety among a group of obese subjects with depression and anxiety. (lifeextension.com)
Oxidative stress5
- Curcumin is well known for its anti-inflammatory and oxidative stress-fighting properties. (lifeextension.com)
- Curcumin, long recognized for its ability to fight both oxidative stress and inflammation, has recently emerged as a leading brain health-promoting supplement. (lifeextension.com)
- This data suggested that curcumin protect the liver and spleen from acute CCL 4 induced injury in a rodent model by suppressing hepatic and splenic oxidative stress expression levels of inflammatory markers. (scialert.net)
- Purpose: To explore the role and mechanism of curcumin (Cur) in reducing oxidative stress damage in rats with nephrolithiasis induced by ethylene glycol (EG). (bvsalud.org)
- Conclusion: Curcumin could reduce the oxidative stress damage caused by EG-induced kidney stones. (bvsalud.org)
1,000 mg1
- For example, taking 1,000 mg a day of a bioavailable curcumin has been found to be more effective than placebo at improving mood-related symptoms on standard depression scales. (lifeextension.com)
Pathways1
- The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/β-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-κB) and signal transducers and activators of transcription (STATs). (nih.gov)
Vitro2
- Although a large number of in vitro targets of curcumin have been identified, the precise chemical-molecular mechanism(s) of its biological activities have not been elucidated. (nih.gov)
- ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFα-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin. (duke.edu)
Therapeutic7
- The concept of oxidative activation could result in a new paradigm of understanding the structure and function of curcumin with important implications for its clinical application as a therapeutic CAM agent. (nih.gov)
- This discovery is significant because it means curcumin pharmacology can now be more precisely targeted for therapeutic results. (totalhealthmagazine.com)
- Overall, these results show a neat little epigenetic mechanism where curcumin exerts a therapeutic role (in a dose dependent manner) in the treatment of neuropathic pain by down-regulating a HAT, which leads to the repression of key activity dependent pain inducing target genes. (epigenie.com)
- Therefore, curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity and spleenotoxicity. (scialert.net)
- Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities against various types of aggressive and recurrent cancers. (nih.gov)
- Of great therapeutic interest, the selective delivery of synthetic analogs or nanotechnology-based formulations of curcumin to tumors, alone or in combination with other anticancer drugs, may improve their chemopreventive and chemotherapeutic efficacies against cancer progression and relapse. (nih.gov)
- Our study demonstrates that curcumin pretreatment accelerated healing of irradiated wound and could be a substantial therapeutic strategy in the management of irradiated wounds. (hilarispublisher.com)
Oleoresin2
- Genetic Toxicity Evaluation of Turmeric, Oleoresin (Curcumin) in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
- Home » Chemical Effects in Biological Systems (CEBS) » Genetic Toxicity Evaluation of Turmeric, Oleoresin (Curcumin) in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Demethoxycurcumin1
- Curcumin Description: Turmeric is produced by grinding the rhizomes of the perennial herb.The colorings responsible for the bright yellow hue of turmeric are the pigments curcumin,demethoxycurcumin a. (21food.com)
20231
- 2023). Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis. (news-medical.net)
Antioxidant3
- Abstract: Curcumin, a polyphenol isolated from the plant turmeric, is recognized for its antioxidant, anti-inflammatory and anti-tumorigenic bioactivities. (nih.gov)
- Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. (jcancer.org)
- Biochemical and gene chip analysis indicated that curcumin at concentrations up to 1 muM propagates its effect via antioxidant-independent mechanisms associated with the phosphorylation-ubiquitin-proteasome pathway. (nih.gov)
Extract9
- Hongda USP Curcumin Extraction Plant Curcumin Extract 95% New Exhibtion Welcome your visit at STAND 7H52 in FI Europe&Ni Dec. 3th-5th. (21food.com)
- Product: Curcumin ,Turmeric Root extract Source Of Plant : Turmeric Root Description : Curcumin is extracted from turmeric root, is regarded as the most development value of edible natural pigment by. (21food.com)
- 1.Pharmaceutical raw materials curcumin extract 95% 2. (21food.com)
- Pharmaceutical raw materials 3.100% natural Curcumin Pharmaceutical raw materials curcumin extract 95% Turmeric Curcumin Powder is a kind of ora. (21food.com)
- Turmeric extract supplier, curcumin 95% powder, curcumin 95% powder extract. (21food.com)
- These statements are based on a human study of NovaSOL® curcumin in comparison with native curcumin extract, using an object measure (metabolite analysis). (solgar.com)
- Based on a human study of NovaSOL® curcumin in comparison with native curcumin extract, using an objective measure (metabolite analysis). (solgar.com)
- Support your wellness journey today with Solgar® Full Spectrum Curcumin Liquid Extract Softgels. (solgar.com)
- Vancouver, CANADA, October 5, 2016 - New biomedical research released today jointly by The Rhema Group and Biologic Pharmamedical, has shown that a trace component of the standard curcumin extract, bisdemethoxycurcumin (BDMC), is proven to be up to 7X more potent on a key anti-inflammatory target than the curcumin extract itself. (totalhealthmagazine.com)
Extracts1
- This new pointed pharmacological research on curcumin reveals that although BDMC exists in extremely low concentrations in standardized curcumin extracts -between 0.5 to 1.5 per cent - it can play a key role in therapy if it is raised to 30 per cent. (totalhealthmagazine.com)
Signaling pathway2
- LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells. (news-medical.net)
- A team led by Heiko Hermeking, Professor of Experimental and Molecular Pathology at LMU, has now demonstrated in cell cultures and in a mouse model that curcumin, a natural substance found in the spice turmeric, can bridge this silenced protective mechanism by activating an alternative, specific signaling pathway that induces the expression of miR-34. (news-medical.net)
Mice6
- We have discovered a novel, previously unrecognized oxidative transformation of curcumin, and we have detected abundant levels of the oxidative metabolites in plasma and intestinal mucosa after oral administration of curcumin to mice. (nih.gov)
- When injected proximal to the sciatic nerve in mice via intramuscular (i.m.) injection, ELP-curcumin conjugates underwent a thermally triggered soluble-insoluble phase transition, leading to in situ formation of a depot that released curcumin over 4days post-injection and decreased plasma AUC 7-fold. (duke.edu)
- A full-thickness dermal excision wound was created on the shaved dorsum of mice orally administered or not with 100 mg/kg body weight of curcumin before partial body exposure to 10, 20 or 40 Gy given as 2 Gy/day for 5, 10 or 20 days. (hilarispublisher.com)
- Fractionated irradiation of mice caused a dose dependent delay in the wound contraction and prolonged wound healing time, whereas curcumin administration prior to fractionated irradiation resulted in a significant rise in the wound contraction and curtailed mean wound healing time. (hilarispublisher.com)
- Fractionated irradiation reduced the synthesis of collagen, DNA and nitric oxide in the regenerating wounds at different post-irradiation times, whereas treatment of mice with curcumin before irradiation elevated the synthesis of collagen, DNA and nitric oxide significantly. (hilarispublisher.com)
- Curcumin was administered chronically to aged Tg2576 mice, or acutely LPS treated wild type mice. (nih.gov)
Boosts3
- The figure above shows how it apparently does work: curcumin boosts the production of the anti-suicide protein XIAP during the R10 phase. (ergo-log.com)
- Curcumin has an anabolic/anticatabolic effect in muscle tissue, it inhibits the conversion of amino acids into energy, it protects the prostate against androgens, boosts the blood vessel widening effect of NO - and may also possibly slow the rate at which your hair turns grey. (ironmagazine.com)
- How curcumin boosts the effects of exercise the Japanese researchers don't know. (ironmagazine.com)
Natural pigment1
- Curcumin, the natural pigment that gives the spice turmeric its yellow color, has increasingly come under the scientific spotlight in recent years, with studies investigating its potential health benefits. (nutraingredients-usa.com)
Mechanism4
- Specifically, we will analyze the mechanism of inhibition of reduced and oxidized IKKß by electrophilic and nucleophilic curcumin metabolites, the mechanism of induction of DNA cleavage by topoisomerase II, and protein and DNA adduct formation by the quinone methide intermediate. (nih.gov)
- In Specific Aim 2 we will identify the products and intermediates of oxidative transformation of curcumin and determine their mechanism of formation. (nih.gov)
- The figure below shows that curcumin had no effect on the uibiquitin-proteasome complex, a mechanism that steers the muscle-protein breakdown machinery. (ergo-log.com)
- This enhancement fortifies the mechanism by which curcumin can inhibit nuclear, MSK1, a facilitative kinase protein central to the inflammatory process," says Cavaleri. (totalhealthmagazine.com)
Colorectal cancer3
- Using genetically-modified human colorectal cancer cell lines, the researchers have now demonstrated that curcumin increases the production of so-called reactive oxygen species (ROS) in tumor cells. (news-medical.net)
- We were also able to confirm in our mouse model that the curcumin-induced expression of miR-34 suppresses the metastasis of colorectal cancer cells into the lung. (news-medical.net)
- Curcumin suppresses metastasis in colorectal cancer (CRC) by modulating crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment, at least in part by the mediation of transforming growth factor-β (TGF-β) and epithelial-mesenchymal transition (EMT) [ 11 ]. (jcancer.org)
Concentrations1
- The biochemical test results showed that the urea (Ur), creatinine (Cr), uric acid (UA), inorganic phosphorus and Ca2+ concentrations in urine decreased after being treated with curcumin. (bvsalud.org)
Inflammation2
- Hidden deep in the plant's bright yellow roots is an extraordinarily powerful compound called curcumin that has the unique ability to block an enzyme that causes inflammation, while combatting free radical damage to highly sensitive vital organs like your brain and heart. (bartonpublishing.com)
- In both the acute (LPS) and chronic inflammation model (Tg2576), TC and curcumin similarly reduced interleukin-1β. (nih.gov)
20191
- 2019 Curcumin is from Jiang Ke, Araceae in the roots of cert. (21food.com)
BDNF3
- Curcumin has been shown, in preclinical and animal studies, to promote the activity of brain-derived neurotropic factor (BDNF) , a vital signaling factor that promotes the growth and strengthening of nerve networks vital to retaining cognitive and memory skills. (lifeextension.com)
- Curcumin stimulates production of an essential growth factor, BDNF , that promotes new connections ( neuronal plasticity ) between brain cells. (lifeextension.com)
- Interestingly, the group also observed a similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord after curcumin treatment. (epigenie.com)
Induce2
- There were already indications in the literature that curcumin can induce miR-34, but there was no systematic investigation of the phenomenon before now. (news-medical.net)
- Researchers are finding that curcumin can reduce anxiety/depression, promote neurite growth and induce brain plasticity. (lifeextension.com)
Derivative1
- The major final product is a dioxygenated cyclopentadione derivative of curcumin. (nih.gov)
Supplements4
- If taking with just water, using a bioavailability-enhanced formula may increase the absorption (see the Best Way to Take Curcumin and Turmeric Supplements for details). (consumerlab.com)
- Turmeric/curcumin supplements are generally safe, but gastrointestinal side effects may occur with higher doses and they can cause problems for people with gallbladder disease, kidney stones, or those taking blood-thinning or blood-sugar-lowering medications. (consumerlab.com)
- I also began to search for organic superfood supplements - one thing led to another, and I found Turmeric Curcumin Plus, one that would eventually change my life for the better. (adustyframe.com)
- There's no healthy aging without a healthy brain, so brain-protecting curcumin should be on every serious person's "A-list" of essential supplements. (lifeextension.com)
Capsules1
- One 40mg Solgar Licaps™ = dozens of 100mg curcumin capsules! (solgar.com)
Complex3
- Bioavailability is enhanced with a curcumin-phosphatidylcholine complex. (greenmedinfo.com)
- Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. (greenmedinfo.com)
- Phospholipid complex of the natural compound curcumin was prepared in order to improve its bioavailability. (greenmedinfo.com)
Efficacy1
- Novel curcumin formulations may also be used to reverse drug resistance, eradicate the total cancer cell mass and improve the anticarcinogenic efficacy of the current anti-hormonal and chemotherapeutic treatments for patients with various aggressive and lethal cancers. (nih.gov)
Inflammatory4
- Curcumin is a potent anti-inflammatory herb that has been demonstrated to protect against a host of degenerative conditions. (lifeextension.com)
- They speculate that curcumin blocks the effect of the inflammatory protein TNF-alpha, but have no data to back this up. (ironmagazine.com)
- Curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. (ironmagazine.com)
- Curcumin (CUR) is the main ingredient of turmeric, has been confirmed to possess anti-inflammatory and anti-oxidative characteristics. (scialert.net)
Protein6
- Curcumin treatment increased muscle XIAP protein levels during reloading above basal levels", the researchers conclude. (ergo-log.com)
- Curcumin attenuates the malignant potential of glioblastoma stem cells by induction of reactive oxygen species (ROS) and activation of the mitogen-activated protein kinase (MAPK) pathway [ 10 ]. (jcancer.org)
- These data indicate that the dienone bridge present in curcumin, but not in TC, is necessary to reduce plaque deposition and protein oxidation in an Alzheimer's model. (nih.gov)
- Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis. (nih.gov)
- CSE caused a reduction in HDAC2 protein expression that was restored by curcumin. (nih.gov)
- This decrease in HDAC2 protein expression was reversed by curcumin even in the presence of cycloheximide, a protein synthesis inhibitor. (nih.gov)
Significantly reduced1
- In addition, reverse transcription polymerase chain reaction (PCR) detection and immunohistochemical results indicated that the osteopontin (OPN) in the kidney was significantly reduced after curcumin treatment. (bvsalud.org)
Specifically1
- Specifically, curcumin and its derivatives protect DNA against oxidative damage induced by reactive oxygen species. (needs.com)
Tumor2
- In addition, curcumin made tumor cells more sensitive to the chemotherapeutic substance 5-FU by means of miR-34. (news-medical.net)
- Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the 'hsa_circRNA_102115'-'hsa-miR-335-3p'-'MAPK1' interaction network. (jcancer.org)
Anticancer1
- Purpose: Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. (mdpi.com)
Rats1
- Methods: Thirty male rats were divided into normal control, model, positive (10% potassium citrate), Cur-10 (10 mg/kg curcumin) and Cur-20 (20 mg/kg curcumin) groups. (bvsalud.org)
Researchers4
- This process of rejuvenation is helped not only by training, but also by taking curcumin [structural formula shown here], researchers at the University of Tsukuba in Japan discovered. (ironmagazine.com)
- Japanese researchers recently published studies in which they studied the effect of curcumin on the blood vessels of post-menopausal women. (ironmagazine.com)
- On this occasion the researchers also had a group of women that took curcumin but did not exercise. (ironmagazine.com)
- Curcumin ingestion alone increases arterial compliance in postmenopausal women", the researchers conclude. (ironmagazine.com)
Findings1
- New research findings show that curcumin can reduce anxiety and depression. (lifeextension.com)
Health supplement1
- Turmeric Curcumin Plus is just one of many health supplement products manufactured by Vita Balance, Inc., a US-based company. (adustyframe.com)
Anabolic1
- But if this animal study confirms that curcumin really has anabolic qualities, we won't be complaining. (ergo-log.com)
Vascular2
- Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. (ironmagazine.com)
- Histological examination revealed a reduction in the collagen deposition, fibroblast and vascular densities after fractionated irradiation, whereas curcumin pretreatment inhibited this decline significantly. (hilarispublisher.com)
Cognitive2
- Turmeric/curcumin may improve cognitive function in healthy older adults, but little benefit has been found in people with Alzheimer's disease. (consumerlab.com)
- From cognitive capabilities to dynamic movements, Turmeric Curcumin Plus guarantees that you'll still be able to live your best life even as you grow in age. (adustyframe.com)
Found3
- With curcumin, we've found a substance with which we could intervene in the signal cascade beneath p53 by activating miR-34,' says Hermeking. (news-medical.net)
- 22 More recently, curcumin has been found to favorably affect two critical processes that are at the core of learning and memory. (lifeextension.com)
- A research team from China investigated how curcumin works to treat neuropathic pain, and found that it prevents the activity regulated expression of certain pain causing genes. (epigenie.com)
Prominent1
- The oxidative transformation of curcumin is rapid, prominent, and gives rise to novel metabolites via reactive intermediates, including a quinone methide and a spiro-epoxide intermediate. (nih.gov)