A genus of zygomycetous fungi of the family Cunninghamellaceae, order MUCORALES. Some species cause systemic infections in humans.
An order of zygomycetous fungi, usually saprophytic, causing damage to food in storage, but which may cause respiratory infection or MUCORMYCOSIS in persons suffering from other debilitating diseases.
Infection in humans and animals caused by any fungus in the order Mucorales (e.g., Absidia, Mucor, Rhizopus etc.) There are many clinical types associated with infection of the central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an opportunistic infection in patients with a chronic debilitating disease, particularly uncontrolled diabetes, or who are receiving immunosuppressive agents. (From Dorland, 28th ed)
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Tricyclic ethylene-bridged naphthalene derivatives. They are found in petroleum residues and coal tar and used as dye intermediates, in the manufacture of plastics, and in insecticides and fungicides.
Cell wall components constituting a polysaccharide core found in fungi. They may act as antigens or structural substrates.
The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both. It also blocks dopamine receptors.
Infection in humans and animals caused by fungi in the class Zygomycetes. It includes MUCORMYCOSIS and entomophthoramycosis. The latter is a tropical infection of subcutaneous tissue or paranasal sinuses caused by fungi in the order Entomophthorales. Phycomycosis, closely related to zygomycosis, describes infection with members of Phycomycetes, an obsolete classification.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Compounds consisting of two or more fused ring structures.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Organometallic compounds which contain tin and three alkyl groups.
Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.
A group of compounds that are derivatives of the amino acid 2-amino-2-methylpropanoic acid.
A genus in the family Trichocomaceae, order EUROTIALES. The anamorph is ASPERGILLUS.
A dye used as a reagent in the determination of vitamin C.
The body of a fungus which is made up of HYPHAE.
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
The reproductive elements of lower organisms, such as BACTERIA; FUNGI; and cryptogamic plants.
Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.

Biotransformation of doxepin by Cunninghamella elegans. (1/48)

A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform doxepin, a tricyclic antidepressant drug. Doxepin is produced as an 85:15% mixture of the trans- (E) and cis- (Z) forms. After 96 h of incubation in Sabouraud dextrose broth, 28% of the drug was metabolized to 16 metabolites. No change in the trans- (E) and cis- (Z) ratio of doxepin was observed. Metabolites were isolated by reversed phase HPLC and identified by (1)H NMR and mass spectroscopic analysis. The major metabolites were (E)-2-hydroxydoxepin, (E)-3-hydroxydoxepin, (Z)-8-hydroxydoxepin, (E)-2-hydroxy-N-desmethyldoxepin, (E)-3-hydroxy-N-desmethyldoxepin, (E)-4-hydroxy-N-desmethyldoxepin, (Z)- and (E)-8-hydroxy-N-desmethyldoxepin, (E)-N-acetyl-N-desmethyldoxepin, (E)-N-desmethyl-N-formyldoxepin, (E)-N-acetyldidesmethyldoxepin, (E)-and (Z)-doxepin-N-oxide, and (E)- and (Z)-N-desmethyldoxepin. Six of the metabolites produced by C. elegans were essentially similar to those obtained in human metabolism studies, although nine novel metabolites were identified.  (+info)

Fungi from geothermal soils in Yellowstone National Park. (2/48)

Geothermal soils near Amphitheater Springs in Yellowstone National Park were characterized by high temperatures (up to 70 degrees C), high heavy metal content, low pH values (down to pH 2.7), sparse vegetation, and limited organic carbon. From these soils we cultured 16 fungal species. Two of these species were thermophilic, and six were thermotolerant. We cultured only three of these species from nearby cool (0 to 22 degrees C) soils. Transect studies revealed that higher numbers of CFUs occurred in and below the root zone of the perennial plant Dichanthelium lanuginosum (hot springs panic grass). The dynamics of fungal CFUs in geothermal soil and nearby nongeothermal soil were investigated for 12 months by examining soil cores and in situ mesocosms. For all of the fungal species studied, the temperature of the soil from which the organisms were cultured corresponded with their optimum axenic growth temperature.  (+info)

Cunninghamella infection post bone marrow transplant: case report and review of the literature. (3/48)

Cunninghamella spp., in the class Zygomycete and order Mucorales, are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Infections with this group of organisms have been seen most frequently in patients with hematologic malignancy. We describe an allogeneic bone marrow recipient who developed fungal pneumonitis and disseminated fungal dermatitis caused by Cunninghamella spp. To our knowledge, this is the first reported case of Cunninghamella infection in a BMT recipient. The case highlights the mortality associated with opportunistic infections in immunocompromised patients and confirms the risk factors associated with non-candida fungal infections after bone marrow transplantation.  (+info)

Transformation of amoxapine by Cunninghamella elegans. (4/48)

We examined Cunninghamella elegans to determine its ability to transform amoxapine, a tricyclic antidepressant belonging to the dibenzoxazepine class of drugs. Approximately 57% of the exogenous amoxapine was metabolized to three metabolites that were isolated by high-performance liquid chromatography and were identified by nuclear magnetic resonance and mass spectrometry as 7-hydroxyamoxapine (48%), N-formyl-7-hydroxyamoxapine (31%), and N-formylamoxapine (21%). 7-Hydroxyamoxapine, a mammalian metabolite with biological activity, now can be produced in milligram quantities for toxicological evaluation.  (+info)

Cluster of pulmonary infections caused by Cunninghamella bertholletiae in immunocompromised patients. (5/48)

Cunninghamella bertholletiae is a rare cause of pulmonary mucormycosis. We describe a cluster of invasive pulmonary infections caused by C. bertholletiae in 4 immunocompromised patients that occurred during a 2-year period at 1 center. Three of the patients were receiving antifungal prophylaxis with itraconazole. Presenting symptoms were fever unresponsive to antibacterial chemotherapy, hemoptysis, and infiltrates on chest radiograms. Three patients were treated with liposomal amphotericin B. Only 1 patient survived.  (+info)

Microbial hydroxylation of (+/-)- and (-)-(2Z,4E)-5-(1',2'-epoxy-2',6',6'-trimethylcyclohexyl)-3-methyl-2,4-pentadienoi c acid into (+/-)- and (-)-xanthoxin acid by Cunninghamella echinulata. (6/48)

Microbial hydroxylation of (+/-)-(2Z,4E)-5-(1',2'-epoxy-2',6',6'-trimethylcyclohexyl)-3-methyl-2,4-pentadien oic acid (3a) with Cercospora cruenta, a fungus producing (+)-abscisic acid, gave a four-stereoisomeric mixture consisting of (+)- and (-)-xanthoxin acid (4a), and (+)- and (-)-epi-xanthoxin acid (5a) by an HPLC analysis with a chiral column. Screening of the microorganisms capable of oxidizing (+/-)-3a showed that Cunninghamella echinulata stereoselectively oxidized (+/-)-3a to xanthoxin acid (4a) with the some degree of enantioselectivity as (-)-3a to (-)-4a.  (+info)

Biotransformation of malachite green by the fungus Cunninghamella elegans. (7/48)

The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.  (+info)

Molecular cloning, expression and characterization of a novel class glutathione S-transferase from the fungus Cunninghamella elegans. (8/48)

The structural gene for glutathione S-transferase (CeGST1-1) in the fungus Cunninghamella elegans was cloned by screening a cDNA library using a degenerate oligonucleotide probe based on the N-terminal sequence of the purified protein. Open reading frame analysis indicated that the cegst1 gene encodes a protein of 210 amino acid residues. The deduced amino acid sequence showed 25% sequence identity with the sequence of the Pi-class GST from Danio rerio (zebrafish). Similarity was also shown with the Alpha-class GST from Fasciola hepatica (liver fluke; 23% identity), the Mu class from Mus musculus (22%) and the Sigma class from Ommastrephes sloani (squid; 21%). Further screening of a cDNA library with the cegst1 gene probe revealed the presence of another GST isoenzyme (CeGST2-2) in this fungus, which shows 84% sequence identity with CeGST1-1 at the amino acid level. Reverse transcription PCR revealed that cegst2 was also expressed at the mRNA level in the fungus C. elegans. Both cegst genes were overexpressed in Escherichia coli using the expression vector pQE51, displaying specific activities with 1-chloro-2,4-dinitrobenzene of 2.04 and 0.75 micromol/min per mg of protein respectively. Both enzymes exhibited a similar substrate specificity and inhibition profile, indicating that CeGST1-1 and CeGST2-2 belong to the same GST class. Mutagenesis analysis revealed that Tyr(10) in the N-terminal region is essential for catalysis of CeGST1-1. We propose from these results that the CeGSTs are novel Gamma-class GSTs and designated as GSTG1-1 and GSTG2-2 respectively.  (+info)

PubMed journal article: Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. Download Prime PubMed App to iPhone, iPad, or Android
Cunninghamella bertholletiae is a species of zygomycetous fungi in the order Mucorales. It is found globally, with increased prevalence in Mediterranean and subtropical climates. It typically displays a saprotrophic lifestyle, and is found in a wide variety of ecological niches, including soil, fruits, vegetables, nuts, crops, and human and animal waste. Although infections are still rare, C. betholletiae is emerging as an opportunistic human pathogen, predominantly in immunocompromised people, leukemia patients, and people with uncontrolled diabetes. Cunninghamella bertholletiae infections are often highly invasive, and can be more difficult to treat with antifungal drugs than infections with other species of the Mucorales, making prompt and accurate recognition and diagnosis of mycoses caused by this fungus an important medical concern. Cunninghamella bertholletiae grows as a mold. Individual cells appear hyaline, but masses of fungi are darker in colour. Colonies initially appear white, and ...
FIG. 4. Proton NMR spectrum (500 MHz) of the major phenanthrene metabolite formed from phenanthrene by C. elegans, shown with resonance assignments. - Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.
Tributyltin (TBT) is one of the most deleterious compounds introduced into natural environment by humans. The ability of Cunninghamella echinulata to degrade tributyltin (TBT) (5 mg l-1) as well as the effect of the xenobiotic on fungal amino acids composition and proteins profile were examined. C. echinulata removed 91% of the initial biocide concentration and formed less hazardous compounds dibutyltin (DBT) and monobutyltin (MBT). Moreover, the fungus produced a hydroxylated metabolite (TBTOH), in which the hydroxyl group was bound directly to the tin atom. Proteomics analysis showed that in the presence of TBT, the abundances of 22 protein bands were changed and the unique overexpressions of peroxiredoxin and nuclease enzymes were observed. Determination of free amino acids showed significant changes in the amounts of 19 from 23 detected metabolites. A parallel increase in the level of selected amino acids such as betaine, alanine, aminoisobutyrate or proline and peroxiredoxin enzyme in ...
Tributyltin (TBT) is one of the most deleterious compounds introduced into natural environment by humans. The ability of Cunninghamella echinulata to degrade tributyltin (TBT) (5 mg l-1) as well as the effect of the xenobiotic on fungal amino acids composition and proteins profile were examined. C. echinulata removed 91% of the initial biocide concentration and formed less hazardous compounds dibutyltin (DBT) and monobutyltin (MBT). Moreover, the fungus produced a hydroxylated metabolite (TBTOH), in which the hydroxyl group was bound directly to the tin atom. Proteomics analysis showed that in the presence of TBT, the abundances of 22 protein bands were changed and the unique overexpressions of peroxiredoxin and nuclease enzymes were observed. Determination of free amino acids showed significant changes in the amounts of 19 from 23 detected metabolites. A parallel increase in the level of selected amino acids such as betaine, alanine, aminoisobutyrate or proline and peroxiredoxin enzyme in ...
Members of this genus are often used in studies investigating the metabolism of drugs, because these species metabolize a wide range of drugs in manners similar to mammalian enzyme systems.[5] Many species are also capable of oxidizing polycyclic aromatic hydrocarbons, a class of stable organic molecules that tends to persist in the environment and contains many known carcinogenic and mutagenic compounds.[6]. The presence of a cytochrome P-450 has been demonstrated in C. bainieri.[7]. ...
The Scientific World Journal is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board is divided into 81 subject areas that are covered within the journals scope.
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View Notes - chap18studyguide from BIO bsc2010 at FSU. Chapter 18 The Genetics of Viruses and Bacteria Study Guide Overview: Microbial Model Systems Viruses and bacteria are the simplest biological
Study Flashcards On Microbial Models: The Genetics of Viruses and Bacteria (vocabulary) at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
This MassBank Record with Accession BML01473 contains the MS2 mass spectrum of 5-Methoxyflavanone with the InChIKey YLLFUILNISGLHO-UHFFFAOYSA-N.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Teknisk-naturvetenskapliga fakulteten, Biologiska sektionen, Institutionen för ekologi och evolution. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Teknisk-naturvetenskapliga fakulteten, Biologiska sektionen, Institutionen för ekologi och evolution, Limnologi. Limnologi. (Microbial Ecology) ...
The study of calcium phosphate coatings, in particular hydroxyapatite for applications on metal implants, has increased in order to improve the interaction between the tissue and the implant. In this work, calcium phosphate thin films were deposited by rf-sputtering and rf-magnetron sputtering techniques over Si and Ti substrates. For the films deposited by rf-sputtering the target was pressed at 2,5x103 kg and sintered at 600° C for 1 h. For the films deposited by rf-magnetron sputtering the target was pressed in the range of 1,5x103 kg to 3,5x103 kg and sintered in the range of RT (room temperature) to 750° C for 1 h. The chemical structure, composition and morphology of the coatings were evaluated using X-ray diffraction (XRD), infrared transmission (FTIR), scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), thickness measurements and bioactivity evaluation over biologic fluid in vitro (SBF) procedures on the sample were made. The purpose of this work was evaluate the ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01) PAR-10-208. NCI
Microbial transformation of hydrocarbons. II. Growth constants and cell composition of microbial cells derived from |em|n|/em|-alkanes | F. Wagner; Th. Kleemann; W. Zahn | download | BookSC. Download books for free. Find books
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol h(-1) (mg of cells)-1. Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cyt ...
A zigomicose (mucormicose) é uma infecção rara, mas altamente invasiva, causada por fungos da ordem Mucorales (gêneros Rhizopus, Mucor, Rhizomucor, Absidia, Apophysomyces, Saksenaea, Cunninghamella, Cokeromyces e Syncephalastrum). Esse tipo de infecção é usualmente associado a doenças hematológicas, cetoacidose diabética e transplante de órgãos. A apresentação clínica mais frequente é a mucormicose rinocerebral, com ou sem envolvimento pulmonar. A zigomicose pulmonar ocorre mais frequentemente em pacientes com neutropenia profunda e prolongada e pode se apresentar como infiltrado lobar ou segmentar, nódulos isolados, lesões cavitárias, hemorragia ou infarto. As manifestações clínicas e radiológicas são na maioria dos casos indistinguíveis daquelas associadas com aspergilose invasiva. Este artigo descreve as características gerais da zigomicose pulmonar, com ênfase no diagnóstico laboratorial, e ilustra a morfologia de algumas lesões ...
chemBlink provides information about CAS # 480-37-5, Pinostrobin, (S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one, 5-Hydroxy-7-methoxyflavanone, 5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one, molecular formula: C16H14O4.
Background: Since androgen-androgen receptor (AR) axis is the main stream for development and progression of prostate cancer, androgen-deprivation therapy (ADT) is conducted as a first line hormonal therapy using medical castration, such as LH-RH agonists, LH-RH antagonist, and antiandrogen for advanced PCa. After an initial response to ADT, however, PCa eventually loses responsiveness to ADT and progresses into castration-resistant prostate cancer (CRPC). Prevention of the development of castration-resistant from hormone-naïve prostate cancer is an important issue in maintaining the quality of life of the patients. We explored the effect of 2-hydroxyflavanone on proliferation and androgen responsiveness using prostate cancer cell lines.. Materials and Methods: To investigate the effect of 2 -hydroxyflavanone on proliferation, prostate cancer cells were treated with 2-hydroxyflavanone. Androgen-responsiveness in LNCaP cells was confirmed by luciferase assay after transfection of luciferase ...
Øjeblikket, er du ser job oplysninger om den Assistant Professor Microbial Metabolite Signaling arbejdspladser stillingsopslag og karriere på Denmark JobsCenter hjemmeside. Læs omhyggeligt arbejdspladser ansøger, job specifikationer og arbejdspladser kvalifikationer, før du anvender de Assistant Professor Microbial Metabolite Signaling job.
Omics group organizes Microbial Transformations national symposiums, conferences across the globe in association with popular Microbial Transformations associations and companies. OMICS group planned its conferences, and events in america, europe, middle east and asia pacific. locations which are popular with international conferences, symposiums and events are china, canada, dubai, uae, france, spain, india, australia, italy, germany, singapore, malaysia, brazil, south korea, san francisco, las vegas, san antonio, omaha, orlando, raleigh, santa clara, chicago, philadelphia, baltimore, united kingdom, valencia, dubai, beijing, hyderabad, bengaluru and mumbai
Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical
Harman Singha stars in one of Indias first sci-fi shows, A.I.SHA, which is in its second season now. As usual, Raghu and Harman addressed the audience in a post-episode video and made an exciting announcement.. One of the commenters said that A.I.SHA deserves to be on Netflix. Raghu commented that Netflix was cool, but they were very happy with Arre. At the end of the conversation, Harman announced Arre will soon have some superhero series too. This is definitely good news for fans of web-series. It is been a while that India has a homegrown superhero.. Netflix became immensely popular after it became home to Marvel superheroes like Jessica Jones, Daredevil, Luke Cage and others. It is interesting to see that an Indian writer announce that a digital platform will soon have superhero shows.. More power to Harman and Arre!. ...
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CBS News Streams Popular Network Programs into Millions of Cars with Aha by HARMAN CBS Evening News, 60 Minutes, Face the Nation, World News Roundup and more are now available as audio stations PALO ALTO, Calif.--(BUSINESS WIRE)-- AhaTM by
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Clayton, W.D., Vorontsova, M.S., Harman, K.T. and Williamson, H. (2006 onwards) GrassBase - The Online World Grass Flora. Triticum. Published online. Accessed 24 Sept. 2013 ...
Ive been pretty happy with my system, which is an old setup consisting of a Quad 44/405-II, Celestion 300s, and a never Harman Kardon HDCD player,
Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognised potential in drug discovery. Herein, the methanol extract of Matricaria recutita L. (German chamomile) and its decoction and infusion (the most consumed preparations of this herb) were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation; the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (non-tumour cells). All the samples revealed antioxidant properties. The decoction exhibited no antitumour activity (GI(50),400 μg/mL) which could indicate that this bioactivity might be related to compounds (including phenolic compounds) that were not extracted or that were ...
MORALES, GLAUCO et al. CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3 ,4 -trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS. J. Chil. Chem. Soc., June 2009, vol.54, no.2, p.105-107. ISSN 0717- ...
Scott Harman has spent several years supporting Democratic candidates for office. But he wanted his own change for years. Now, Harman is taking on Republican incumbent state Sen. Bryan Simonaire in District 31.
Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through die …
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) has been established at the Faculty of Health Sciences, University of Copenhagen to conduct basic research on metabolism (www.metabol.ku.dk). The Center, which consists of six scientific sections and a number of international research satellites, was established through a DKK 885 million unrestricted grant from the Novo Nordisk Foundation. We are a center of excellence where talented researchers and experienced laboratory technicians is bringing scientific discoveries from the laboratory to the society in an effort to tackle some of todays biggest challenges - diabetes and obesity. We are proud of the outstanding discoveries made by the Center, and we are committed to the translation of this knowledge into novel approaches to patient care. The position is in the Section for Metabolic Receptology headed by Scientific Director Thue W. Schwartz and in the Group of Professor Fredrik Bäckhed. The research in this Group is ...
By taking the EC solution as a reference, we evaluated MM and ECA kinetics for their abilities to represent several differently configured enzyme-substrate reaction networks. In applying the ECA and MM kinetics to microbial models of different complexities, we found (i) both the ECA and MM kinetics accurately reproduced the EC solution when multiple microbes are competing for a single substrate; (ii) ECA outperformed MM kinetics in reproducing the EC solution when a single microbe is feeding on multiple substrates; (iii) the MM kinetics failed, while the ECA kinetics succeeded, in reproducing the EC solution when multiple consumers (i.e., microbes and mineral surfaces) were competing for multiple substrates. We then applied the EC and ECA kinetics to a guild based C-only microbial litter decomposition model and found that both approaches successfully simulated the commonly observed (i) two-phase temporal evolution of the decomposition dynamics; (ii) final asymptotic convergence of the ...
OBJECTIVE-We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS-With two parallel approaches-a fat body-specific green fluorescent protein enhancer trap screen in D. melanogaster and expression profiling of developing murine fat tissues-we identified Atf4 as expressed in invertebrate and vertebrate metabolic tissues. We assessed the functional relevance of the evolutionarily conserved expression by analyzing Atf4 mutant flies and Atf4 mutant mice for possible metabolic phenotypes. RESULTS-Flies with insertions at the Atf4 locus have reduced fat content, increased starvation sensitivity, and lower levels of circulating carbohydrate. Atf4 null mice are also lean, and they resist age-related and diet-induced, obesity. Atf4 null mice have increased energy expenditure potentially accounting for the lean phenotype. Atf4 null mice are hypoglycemic, even before substantial changes in fat content, indicating that ...
Harman Kardon has departed from its austere design language on occasion and come up with some questionable aesthetic results, but its latest compact stereo system sports the clean and classic lines for which H/K is famed.
Harman International Industries, Incorporated (NYSE:HAR) announced the acquisition of Wavemakers Inc. located in Vancouver, British Columbia.
Top ⭐ 15 reasons for AKG K514 MKII vs Harman Kardon CL: 1. Highest frequency: 20000 vs 20000 2. Lowest frequency: 16 vs 16 3. Weight: 190 vs 195 4. Impedance: 32 vs 32
As the first alternate in The Players Championship field, Brian Harman had to figure there was a pretty good chance hed be teeing it up at TPC Sawgrass this week. So he showed up on Thursday morning and hung around … Continue reading →
Driving, or being driven in, a Maserati is a uniquely rousing experience. So its only fitting that the vehicle has an audio system always perfectly in tune with the mood - whether youre driving hard or soaking up the miles on the trip of a lifetime. This comes in the shape of new premium audio systems from worldclass audio innovator Harman Kardon - tailor-made for the interiors of the GranTurismo. The system features AuraVox sound tuning and Harman Kardon sound processing technologies. These are exceptionally advanced packages that deliver distortion-free and detail-rich listening enjoyment in all four seats. As for the styling, advanced technology allows the powerful speakers to be exceptionally compact so they integrate seamlessly with each interior. There is also, of course, the inimitably elegant yet hi-tech look of the Harman Kardon brand to enjoy .. ...
SCH 351448, a microbial metabolite produced from the fermentation broth of a Micromonospora sp., was undergoing preclinical investigation with Schering Plough
Microoganisms are distributed across every ecosystem, and microbial transformations are fundamental to the operation of the biosphere. Microbial ecology is the study of this interaction between microorganisms and their environment, and arguably…
I just ran the tests again with 1 million iterations of the loop. The results are more inline with what you are describing. Here are the results:
Portable, powerful and ready to party, the JBL PartyBox On-The-Go and PartyBox 310 are here. Designed for the ultimate mobile party, the new speakers pair powerful JBL Pro Sound with a light show that syncs to the music,...
Clayton, W.D., Vorontsova, M.S., Harman, K.T. and Williamson, H. (2006 onwards) GrassBase - The Online World Grass Flora. Secale. Published online. Accessed 26 Sept. 2013 ...
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The present book is a collection of twenty different articles from across the globe divided into four basic themes of microbial fertilizers, microbial metabolites, microbes in health and microbial fuels. The first chapter discusses removal of undesirable compounds from soil by a process called rhizoremediation. Sustainability of the ecosystem is greatly needed, which is pertinently covered in the first sub-theme of this volume. The second sub-theme of this collection focuses on diverse types of microbial metabolites with chapters on biosurfactants, carotenoids, organic acids, antibiotics and biosensors, each of which is important and significant in its own way. The third sub-theme of the book is enriched by a discussion on microbes in health with four chapters, each explaining probiotics, direct fed microbials (DFMs), the role of microbes in the production of vaccines, and survival mechanisms of human pathogenic fungi. The chapter on probiotics elucidates the role of microbiota in development of ...
The Program in Microbiology and Molecular Genetics (MMG) provides training in the study of microorganisms as well as in the use of microbial models to investigate basic problems in molecular genetics. The program is designed not only for students interested in academic careers in teaching and research, but also for those interested in careers in related aspects of medicine and industry. Research training is offered in bacterial genetics and physiology, microbial development, molecular biology of viruses and bacterial pathogens, mechanisms of bacterial and viral pathogenesis, molecular biology of gene regulation, antibiotic resistance, antiviral and vaccine development. ...
Harman shows how, within the most miniscule of worlds, Darlington sought answers to the biggest questions -- how species originate, how variation occurs. But Darlington did not stop there: Chromosomes held untold, dark truths about man and his culture. This conviction led once-famed Darlington down a path of rebuke, isolation, and finally obscurity.
Just wanted to throw some info out there if it can possibly help anyone… Ive been using my Harman for about 2 months now, and the last 5 weeks or so things have gone pretty well (after cleaning out the back of my stove). I still get mild back-puffing from time to time, so I wanted to describe our specific situation and what has helped us with it. When I say mild back-puffing, what I mean is that all of the sudden well hear the whuff noise and see a plume of smoke arise from our stove. Nothing very violent, no doors being blown off or anything even close to that. It seems to happen when we rush things along too quickly as were getting the fire going. Specifically, when we start to add bigger pieces, we still have the damper open to promote the transitioning of those pieces from phase 1 burning (flaming), to phase 2 burning (glowing). Thats oversimplifying it, but hopefully you know what I mean. When we shut the damper too early, when the wood hasnt fully transitioned to phase 2, we ...
Just wanted to throw some info out there if it can possibly help anyone… Ive been using my Harman for about 2 months now, and the last 5 weeks or so things have gone pretty well (after cleaning out the back of my stove). I still get mild back-puffing from time to time, so I wanted to describe our specific situation and what has helped us with it. When I say mild back-puffing, what I mean is that all of the sudden well hear the whuff noise and see a plume of smoke arise from our stove. Nothing very violent, no doors being blown off or anything even close to that. It seems to happen when we rush things along too quickly as were getting the fire going. Specifically, when we start to add bigger pieces, we still have the damper open to promote the transitioning of those pieces from phase 1 burning (flaming), to phase 2 burning (glowing). Thats oversimplifying it, but hopefully you know what I mean. When we shut the damper too early, when the wood hasnt fully transitioned to phase 2, we ...
CES 2020, LAS VEGAS - JANUARY 6, 2020 - HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is announcing its entry into the gaming...
MCL applicants should only apply for either the Harman or Faculty Scholar RFA, not both. If applicant applies for both mechanisms, their application may not be accepted.. Letter of Intent: Submit your letter of intent (LOI) with biosketch and other support page at the following link below, per the application instructions. You do not need to submit your LOI via your RPM.. ...
Building upon the legacy of one of the most successful microphone families in the world, AKG by Harman has introduced the C314 dual-diaphragm condenser micropho
Brian Harman had two eagles in a 6-under 65 that gave him a one-stroke lead after three rounds of the John Deere Classic on Saturday.
Aug 27 - There are no signs of a slowdown in luxury sales in China with consumers still buying high-end car brands like BMW, Porsche and Audi, according to Harman CEO, Dinesh Paliwal.}
Chronic disease. The highest form of cyclical development Aspergillius niger is Bakterium tuberkulosis. This bacterium is responsible for the transition to a chronic form of the disease. Its activation and growth are the result of frequent use of antibiotics or antifungal agents. Modern immunosuppressive drugs (antibiotics, corticoids and t'd ') are a common cause of microbial transformation in the so-called CWD - forms: bacteria without cell walls. This applies to Mycobacterium tuberculosis ...
If youre hosting this Thanksgiving, and even if youre not, check out these creative ideas for making your home warm and inviting.
2017 PARCLE GROUP SRL - PLAYBOY, PLAYMATE, PLAYMATE OF THE MONTH, PLAYMATE OF THE YEAR, RABBIT HEAD DESIGN AND FEMLIN DESIGN ARE TRADEMARKS OF AND USED UNDER LICENSE FROM PLAYBOY ENTERPRISES INTERNATIONAL, INC.. ...
I was first introduced to valerian as a sleeping aid. Ive never personally used it as Ive been functioning as a perfect morning bird/night owl hybrid for years, but we had some family members struggling with sleep and valerian is something that popped up in research. Theres a little more than sleep associated with valerian…
In this edition of The Wired Practice, Ron Harman King lays down the 4 commandments for confronting bad PR coverage, including dont hide & act with empathy.
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Janet Munro.....Jennie Jones John Stride.....Bob Williams Anne Cunningham.....Ella Alan Badel.....Karl Denny Vanda Godsell..... ...
Cunninghamella elegans, a fungal model organism of the mammalian metabolism, can be used to study the naringenin sulfation. ... Ibrahim AR (January 2000). "Sulfation of naringenin by Cunninghamella elegans". Phytochemistry. 53 (2): 209-12. doi:10.1016/ ...
Fungi like Cunninghamella elegans can be used as a microbial model of mammalian drug metabolism thereby reducing the need for ... Joanna D. Moody; Donglu Zhang; Thomas M. Heinze; Carl E. Cerniglia (2000). "Transformation of amoxapine by Cunninghamella ... Furosemide glucoside formation using the fungus Cunninghamella elegans". Drug Metabolism and Disposition. 21 (2): 259-267. PMID ... "Inducible nature of the steroid 11-hydroxylases in spores of Cunninghamella elegans (Lendner)". Journal of Basic Microbiology. ...
"Biotransformation of Cinobufagin by Cunninghamella elegans" (PDF). The Journal of Antibiotics. 60 (4): 261-264. doi:10.1038/ja. ...
"Metabolism of metolachlor by the fungus Cunninghamella elegans". Arch. Environ. Contam. Toxicol. 32 (2): 117-125. doi:10.1007/ ...
"Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans". The Journal of Steroid ...
... demethylation followed by sulfation occur in model organism Cunninghamella elegans. Sakuranetin on home.ncifcrf.gov Sakuranetin ... "O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans". Chemical & Pharmaceutical Bulletin. 51 ( ...
Cunninghamella species are commonly encountered in forest soils, dung, and nuts from the tropics. Species can be isolated using ... According to Benny and Alexopoulos, the family only contains the genus Cunninghamella. However, other (recent) authors have ...
The fungus Cunninghamella elegans is also able to degrade synthetic phenolic compounds like bisphenol A. Portulaca oleracea ... "Biodegradation of bisphenol A and its halogenated analogues by Cunninghamella elegans ATCC36112". Biodegradation. 21 (6): 989- ...
More research on this fungal species; Cunninghamella japonica, and others, is likely to appear in the near future. The recent ...
The model fungus Cunninghamella elegans produces, in the case of the biodegradation of phenanthrene, a glucoside conjugate of 1 ... "Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans". Applied and ...
Cunninghamella elegans is a candidate for use as a model for mammalian drug metabolism. Plant cytochrome P450s are involved in ...
Generally, species in the Mucor, Rhizopus, Absidia, and Cunninghamella genera are most often implicated. The disease is often ...
obtained the 28-O-β-D-glucopyranoside of betulinic acid by microbial transformation with Cunninghamella species, while Baglin ...
Cunninghamella elegans is a candidate for use as a model for mammalian drug metabolism. ...
... for instance Cunninghamella elegans UCP 542). List of Jesuit sites Foundation Day "Relatório de Administração" (in Portuguese ...
... and Cunninghamella elegans and their detection in urine samples". Analytical and Bioanalytical Chemistry. 411 (16): 3561-3579. ...
Cunninghamella elegans on seenmudel imetajate ravimite metabolismi uurimiseks.[10]. *Neurospora crassat ehk oranži ... Transformation of Amoxapine by Cunninghamella elegans Applied Environmetal Microbiology. 2000 August; 66(8): 3646-3649 ...
... cunninghamella MeSH B05.975.550.480 - mortierella MeSH B05.975.550.500 - mucor MeSH B05.975.550.750 - phycomyces MeSH B05.975. ...
... a moth species found in North America Cunninghamella intermedia, a fungus species Cyclopia intermedia, the honeybush, a plant ...
... a species Family Cunninghamellaceae Cunninghamella elegans, a species found in soil and also used as a model of mammalian ... elegans Cucullaea elegans Cucullanus elegans Culeolus elegans Culex elegans Cumingia elegans Cuneolina elegans Cunninghamella ...
... a plant community Cunninghamella A18, a fungus strain A18, one of the Encyclopaedia of Chess Openings codes for the English ...
... a tree species Cunninghamella africana, a fungus species Carissa africana, a synonym for Carissa spinarum, the conkerberry or ...
... a plant used in traditional Native American medicine Cunninghamella polymorpha, a pin mold This disambiguation page lists ...
... a mold species in the genus Curvularia Cunninghamella clavata, a soil fungus species This disambiguation page lists articles ...
Absidia padenii Absidia repens Backusella circina Circinella umbellata Cokeromyces recurvatus Cunninghamella echinulata ...
... a species of yeast Cunninghamella echinulata var. antarctica, a subspecies of fungus Deschampsia antarctica, a flowering plant ...
... a plant subspecies Cunninghamella elegans elegans, a fungus subspecies Cymatoderma elegans elegans, a fungus subspecies ...
... binarieae R.Y.Zheng 2001 Cunninghamella blakesleeana Cunninghamella candida Yosh.Yamam. 1929 Cunninghamella ... Mantri 1966 Cunninghamella multiverticillata R.Y.Zheng & G.Q. Chen 2001 Cunninghamella phaeospora Boedijn 1959 Cunninghamella ... ex Blakeslee 1905 Cunninghamella elegans Lendn. 1905 Cunninghamella homothallica Komin. & Tubaki 1952 Cunninghamella intermedia ... Cunninghamella is a genus of fungi in the order Mucorales, and the family Cunninghamellaceae. The genus was circumscribed by ...
... is a fungal species in the genus Cunninghamella. It is an asexually reproducing fungus and a ... Cunninghamella echinulata grown in yeast extract broth, trypticase soy medium or peptone broth at a pH of 8 yielded 0 μg/ml of ... Cunninghamella echinulata is a saprotrophic resident of the soils in warmer regions of the world, particularly those enriched ... Cunninghamella echinulata reproduces asexually and solely via yellow-brown, spiny, single-spored sporangioles that, due to the ...
"Synonymy: Cunninghamella Matr". Species Fungorum. CAB International. Retrieved 2015-09-21.. *^ Cunninghamella at the US ... Cunninghamella africana". Annales Mycologici (in French). 1: 45-60.. *^ "Species Fungorum (version 26th August 2015). In: ... Cunninghamella is a genus of fungi in the order Mucorales, and the family Cunninghamellaceae.[2] The genus was circumscribed by ... Asha S, Vidyavathi M (2009). "Cunninghamella--a microbial model for drug metabolism studies--a review". Biotechnol. Adv. 27 (1 ...
Cunninghamella echinulata is a fungal species in the genus Cunninghamella. It is an asexually reproducing fungus and a ... Cunninghamella echinulata grown in yeast extract broth, trypticase soy medium or peptone broth at a pH of 8 yielded 0 μg/ml of ... Cunninghamella echinulata is a saprotrophic resident of the soils in warmer regions of the world, particularly those enriched ... Cunninghamella echinulata reproduces asexually and solely via yellow-brown, spiny, single-spored sporangioles that, due to the ...
Biotransformation of doxepin by Cunninghamella elegans. Download Prime PubMed App to iPhone, iPad, or Android ... "Biotransformation of Doxepin By Cunninghamella Elegans." Drug Metabolism and Disposition: the Biological Fate of Chemicals, vol ... A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform ... TY - JOUR T1 - Biotransformation of doxepin by Cunninghamella elegans. AU - Moody,J D, AU - Freeman,J P, AU - Cerniglia,C E, PY ...
Associations of Cunninghamella with chemical compounds. *Cunninghamella elegans grown on Sabouraud dextrose broth in the ... Metabolism of naphthalene by Cunninghamella elegans [13].. *The metabolism of phenanthrene by the fungus Cunninghamella elegans ... Biotransformation of malachite green by the fungus Cunninghamella elegans [9].. *The filamentous fungus Cunninghamella elegans ... Disease relevance of Cunninghamella. *The mutagenic activity of ethyl acetate extracts of culture medium from Cunninghamella ...
The etiological agent was diagnosed to be,i, Cunninghamella bertholletiae,/i,, a fungus pertaining to the order Mucorales ( ... This case demonstrates the association of onychomycosis with,i, Cunninghamella bertholletiae,/i, in an immune competent ... Cunninghamella spp. can be found at the lab as environmental contaminants [4]. However, an isolate of C. bertholletiae from any ... Onychomycosis due to Cunninghamella bertholletiae in an Immunocompetent Male from Central India,. Case Reports in Infectious ...
Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. Download Prime PubMed App to iPhone, iPad, or ... Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana.. *Transformation of verapamil by Cunninghamella ... "Biotransformation of Pantoprazole By the Fungus Cunninghamella Blakesleeana." Xenobiotica; the Fate of Foreign Compounds in ... TY - JOUR T1 - Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. AU - Xie,Z Y, AU - Huang,H H, AU - ...
sp,O60037,6PGD_CUNEL 6-phosphogluconate dehydrogenase, decarboxylating OS=Cunninghamella elegans OX=4853 GN=6-PGD PE=2 SV=1 ... Cunninghamella elegans. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names ...
... Shuwahida ... "Strategic Feeding of Ammonium and Metal Ions for Enhanced GLA-Rich Lipid Accumulation in Cunninghamella bainieri 2A1," The ...
... was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17α-pregn-4-en-20-yn-3-one-10β,17β-diol (2), 19-nor- ...
In this research study, a strain of Cunninghamella elegans (UCP 596) was isolated from mangrove sediments to metabolize an ... Eukaryotic organisms, such as Cunninghamella elegans, grow on DBT by forming DBT-5-oxide and DBT-5-dioxide, but biphenyl is not ... Suggestion for metabolic pathway used by Cunninghamella elegans (UCP 596) to remove the sulfur from the DBT inserted into the ... In this research study, a strain of Cunninghamella elegans (UCP 596) was isolated from mangrove sediments to metabolize an ...
Furosemide glucoside formation using the fungus Cunninghamella elegans. Message Subject (Your Name) has forwarded a page to you ... Furosemide glucoside formation using the fungus Cunninghamella elegans.. M Hezari and P J Davis ... Furosemide glucoside formation using the fungus Cunninghamella elegans.. M Hezari and P J Davis ... Furosemide glucoside formation using the fungus Cunninghamella elegans.. M Hezari and P J Davis ...
Our report describes an unusual case of rhinofacial zygomycosis due to Cunninghamella sp. in an immunocompetent patient, who ... An unusual presentation of rhinofacial zygomycosis due to Cunninghamella sp. in an immunocompetent patient: a case report and ... Our report describes an unusual case of rhinofacial zygomycosis due to Cunninghamella sp. in an immunocompetent patient, who ...
In vitro metabolic systems consisting of the fungi Cunninghamella elegans and Cunninghamella blakesleeana were incubated with ... Cunninghamella blakesleeana, Cunninghamella elegans, Doping Control, Drug Metabolites, Glucuronide Production, Mass ... S4 and S24 by the fungi Cunninghamella elegans and Cunninghamella blakesleeana was investigated. The detected metabolites were ... The discovery that the fungus Cunninghamella elegans formed large amounts of glucosides led to the idea that they could be used ...
All three metal ions also affected GLA production by Cunninghamella sp. 2A1 with Zn2+ having the most profound effect with an ... This study reports the critical concentration of each metal ion for optimal lipid and GLA production by Cunninghamella sp. 2A1. ... CuSO4.5H2O and MnSO4.5H2O on lipid and GLA production by Cunninghamella sp. 2A1 were studied in submerged culture fermentation ... All three metal ions also affected GLA production by Cunninghamella sp. 2A1 with Zn2+ having the most profound effect with an ...
Rights & permissionsfor article Biotransformation of metoprolol by the fungus ,i,Cunninghamella blakesleeana,/i, . Opens in a ...
The ability of Cunninghamella echinulata to degrade tributyltin (TBT) (5 mg l-1) as well as the effect of the xenobiotic on ...
The CYPome of the model xenobiotic-biotransforming fungus Cunninghamella elegans *William Palmer-Brown ... Rights & permissionsfor article The CYPome of the model xenobiotic-biotransforming fungus ,i,Cunninghamella elegans,/i, . Opens ...
One comment suggested adding Zygomycetes (specifically, Mucor, Rhizopus, Absidia, and Cunninghamella) to the list of qualifying ...
Our earlier paper had established the fact that new soil fungi known as Cunninghamella blakesleeana is potent enough to produce ... Our earlier paper had established the fact that new soil fungi known as Cunninghamella blakesleeana is potent enough to produce ... Our earlier paper had established the fact that new soil fungi known as Cunninghamella blakesleeana is potent enough to produce ... SSF was carried using the pure culture of Cunninghamella blakesleeana KP780148.1 with wheat bran as substrate. Initial ...
Full text: Available Index: LILACS (Americas) Main subject: Bromhexine / Cunninghamella Limits: Animals Language: English ... The role of CYP3A4 enzyme in metabolism of bromhexine and the presence of these enzymes in Cunninghamella species was confirmed ... Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleea Biotransformation of bromhexine by ... We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for ...
Fungal metabolism of acenaphthene by Cunninghamella elegans. Identification of metabolites from the degradation of fluoranthene ... A study was conducted on the in vitro metabolism of N-substituted phenothiazines by Cunninghamella elegans (C. elegans). The ... Fungal metabolism of acenaphthene by Cunninghamella elegans. Article Abstract:. Acenaphthene, a polycyclic aromatic hydrocarbon ... The metabolic pathway of acenaphtene degradation by Cunninghamella elegans was elucidated. The results showed that acenaphthene ...
... ... The mircrobiological transformation of progesterone by a local isolate of Cunninghamella echiiiulata using a laboratory ... hydroxylation of pregesterone by cunninghamella echinulata on a laboratory fermentor scale.pdf (281.2Kb) ...
Inoculum for a local isolate of oleaginus fungi, Cunninghamella bainieri 2A1 was developed by establishing the inoculum types, ... Inoculum development for lipid and gamma linoenic asid production by Cunninghamella bainieri2A1) ... Inoculum development for lipid and gamma linoenic asid production by Cunninghamella bainieri2A1). Sains Malaysiana, 41 (4). pp ...
Microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153 Microbial transformation of buflomedil by ... The microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153 was studied, as well as a microbial model ... Experiments were conducted to screen the capabilities of four strains of Cunninghamella species to transform buflomedil, in ... Adult , Animals , Biotransformation , Chromatography, High Pressure Liquid , Cunninghamella , Metabolism , Dogs , Female , ...
Mechanism of reversal of inhibition of endogenous respiration in Cunninghamella echinulata by intermediate-chain-length fatty ...
Microbiological processes were used for chitin and chitosan production with Cunninghamella elegans UCP/WFCC 0542 grown in ...
Cunninghamella echinulata. [78]. Quercetin 3-O-β-d-glucopyranoside. Isorhamnetin 3-O-β-d-glucopyranoside Cunninghamella elegans ... Cunninghamella elegans and Cunninghamella echinulata are known to be capable of glycosylating phenolic compounds [63,67,68,81 ... Cunninghamella blakesleeana [66], Streptomyces fulvissimus [2], and Mucor ramannianus [80]. Rutin incubated with Cunninghamella ... Zi, J.; Valiente, J.; Zeng, J.; Zhan, J. Metabolism of quercetin by Cunninghamella elegans ATCC 9245. J. Biosci. Bioeng. 2011, ...
Cunninghamella spp. 5 (6.5) 4 (14.3) 9 (8.6) Lichtheimia spp.† 3 (3.9) 0 3 (2.9) Apophysomyces spp. 1 (1.3) 0 1 (1.0) ...
Cunninghamella echinulata. A filamentous fungus generally found in soil and plant material in subtropical and Mediterranean ... Cunninghamella Species. (2007, January 1). Retrieved November 11, 2014, from http://www.doctorfungus.org/Thefungi/ ... cunninghamella.php. Fungi and Mycology. (2007, January 1). Retrieved November 11, 2014, from http://www.doctorfungus.org/ ...
  • ex Blakeslee 1905 Cunninghamella elegans Lendn. (wikipedia.org)
  • A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform doxepin, a tricyclic antidepressant drug. (unboundmedicine.com)
  • TY - JOUR T1 - Biotransformation of doxepin by Cunninghamella elegans. (unboundmedicine.com)
  • To investigate the biotransformation of pantoprazole, a proton-pump inhibitor, by filamentous fungus and further to compare the similarities between microbial transformation and mammalian metabolism of pantoprazole, four strains of Cunninghamella (C. blakesleeana AS 3.153, C. echinulata AS 3.2004, C. elegans AS 3.156, and AS 3.2028) were screened for the ability to catalyze the biotransformation of pantoprazole. (unboundmedicine.com)
  • In this research study, a strain of Cunninghamella elegans (UCP 596) was isolated from mangrove sediments to metabolize an organosulfur dibenzothiophene (DBT) compound in the concentrations of 0.5 and 1 mM and transform to DBT sulfone (DBT-5-dioxide), followed by dibenzothiophene 5,5-dioxide and 2-hydroxybiphenyl metabolites, thus suggesting the use of the "4S" metabolic pathway. (intechopen.com)
  • Furosemide glucoside formation using the fungus Cunninghamella elegans. (aspetjournals.org)
  • The diuretic furosemide (Lasix) was metabolized by the fungus Cunninghamella elegans (ATCC 36112) to the phase II conjugate, furosemide acyl glucoside. (aspetjournals.org)
  • In vitro metabolic systems consisting of the fungi Cunninghamella elegans and Cunninghamella blakesleeana were incubated with bupivacaine and bupivacaine-d 9 . (diva-portal.org)
  • The metabolism of bupivacaine and the selective androgen receptor modulators (SARMs) S1, S4 and S24 by the fungi Cunninghamella elegans and Cunninghamella blakesleeana was investigated. (diva-portal.org)
  • Fungal metabolism of acenaphthene by Cunninghamella elegans. (readabstracts.com)
  • The metabolic pathway of acenaphtene degradation by Cunninghamella elegans was elucidated. (readabstracts.com)
  • A study was conducted on the in vitro metabolism of N-substituted phenothiazines by Cunninghamella elegans (C. elegans). (readabstracts.com)
  • Figure 4 from Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. (semanticscholar.org)
  • Stereoselective metabolism of anthracene and phenanthrene by the fungus Cunninghamella elegans. (semanticscholar.org)
  • This study examines the in vitro metabolism of EG-018 and its 5F-analogue EG-2201 by means of comparing three different in vitro models: pooled human liver microsomes, cytochrome P450 isoenzymes, and a fungal approach utilizing the filamentous fungus Cunninghamella elegans LENDNER, which is known for its ability to mimic human biotransformation of xenobiotics. (dshs-koeln.de)
  • Although fungal incubation with Cunninghamella elegans yielded an additional three EG-018 and four EG-2201 metabolites not observed after microsomal incubation, metabolites generated by Cunninghamella elegans were in good correlation with those generated by microsomal incubations. (dshs-koeln.de)
  • NCE312, Neptunomonas naphthovorans, and the fungus Cunninghamella elegans . (ethz.ch)
  • Others include Mucor species, Cunninghamella bertholletiae , Apophysomyces species, and Lichtheimia (formerly Absidia ) species. (cdc.gov)
  • Mucormicosis is a fungal opportunistic infection produced by various species of Mucorales , such as Rhizopus, Mucor, Cunninghamella and Absidia . (scielo.cl)
  • In descending order, the other genera with mucormycosis-causing species include Mucor , Cunninghamella , Apophysomyces , Lichtheimia (formerly Absidia ), Saksenaea , Rhizomucor , and other species. (medscape.com)
  • Invasive zygomycosis is a well-defined clinical syndrome associated with fungi in the genera Rhizopus, Mucor, Absidia, Rhizomucor , and Cunninghamella. (thefreedictionary.com)
  • 1929 Cunninghamella clavata R.Y.Zheng & G.Q.Chen 1998 Cunninghamella echinulata (Thaxt. (wikipedia.org)
  • Cunninghamella echinulata is a fungal species in the genus Cunninghamella. (wikipedia.org)
  • Cunninghamella echinulata is a member of the family, Cunninghamellaceae (phylum Mucoromycota). (wikipedia.org)
  • Cunninghamella echinulata reproduces asexually and solely via yellow-brown, spiny, single-spored sporangioles that, due to the nature of the sporangiospore being retained within the sporangium, appear to have a two-layered outer wall. (wikipedia.org)
  • Cunninghamella echinulata and other species of Cunninghamellaceae can be selectively grown on Czapek's solution agar, a property unique to this family of the Mucorales. (wikipedia.org)
  • Cunninghamella echinulata is able to grow on orange rind and assimilate carbohydrates into necessary biomolecules, where the fermented peel does not exhibit appreciable discolouration or odour. (wikipedia.org)
  • Cunninghamella echinulata grown in yeast extract broth, trypticase soy medium or peptone broth at a pH of 8 yielded 0 μg/ml of breakdown products from the metabolism of rac-mexiletine. (wikipedia.org)
  • In order to achieve the highest quantity of GLA, Cunninghamella echinulata grows preferentially on nitrogen-depleted media with a C/N (carbon:nitrogen) molar ratio of 169. (wikipedia.org)
  • The ability of Cunninghamella echinulata to degrade tributyltin (TBT) (5 mg l-1) as well as the effect of the xenobiotic on fungal amino acids composition and proteins profile were examined. (lodz.pl)
  • The etiological agent was diagnosed to be Cunninghamella bertholletiae , a fungus pertaining to the order Mucorales (subdivision Mucoromycotina) and known for some of the invasive lesions among immunocompromised patients. (hindawi.com)
  • This case demonstrates the association of onychomycosis with Cunninghamella bertholletiae in an immune competent individual, not reported so far. (hindawi.com)
  • Cunninghamella bertholletiae (order Mucorales, subdivision Mucoromycotina) is a saprophytic, ubiquitous fungus found in soil [ 1 ]. (hindawi.com)
  • 5 Other examples include Rhizomucor species, Syncephalastrum species, Cunninghamella bertholletiae , Apophysomyces, Lichtheimia (formerly Absidia ) , Saksenaea, and Rhizomucor . (cdc.gov)
  • Decreased susceptibility to amphotericin B was noted with Cunninghamella bertholletiae . (asm.org)
  • Cunninghamella is a genus of fungi in the order Mucorales , and the family Cunninghamellaceae . (wikipedia.org)
  • This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. (diva-portal.org)
  • Our earlier paper had established the fact that new soil fungi known as Cunninghamella blakesleeana is potent enough to produce lovastatin significantly. (researchsquare.com)
  • Inoculum for a local isolate of oleaginus fungi, Cunninghamella bainieri 2A1 was developed by establishing the inoculum types, age and size for growth, lipid and gamma linolenic acid (GLA) production. (ukm.my)
  • A filamentous fungi Cunninghamella blakesleeana transformed albendazole to three metabolites in significant quantities. (ebscohost.com)
  • As of 2015[update], Index Fungorum lists 13 valid species of Cunninghamella: Cunninghamella binarieae R.Y.Zheng 2001 Cunninghamella blakesleeana Cunninghamella candida Yosh.Yamam. (wikipedia.org)
  • Mantri 1966 Cunninghamella multiverticillata R.Y.Zheng & G.Q. Chen 2001 Cunninghamella phaeospora Boedijn 1959 Cunninghamella polymorpha Pišpek 1929 Cunninghamella septata R.Y.Zheng 2001 Cunninghamella vesiculosa P.C.Misra 1966 Members of this genus are often used in studies investigating the metabolism of drugs, because these species metabolize a wide range of drugs in manners similar to mammalian enzyme systems. (wikipedia.org)
  • The role of CYP3A4 enzyme in metabolism of bromhexine and the presence of these enzymes in Cunninghamella species was confirmed due to absence of peaks at 4.7, 5.4 and 6.7 min when RLM were incubated with a CYP3A4 enzyme inhibitor - clarithromycin . (bvsalud.org)
  • Experiments were conducted to screen the capabilities of four strains of Cunninghamella species to transform buflomedil, in which C. blakesleana AS 3.153 was selected for a preparative biotransformation . (bvsalud.org)
  • Cunninghamella species are commonly encountered in forest soils, dung, and nuts from the tropics. (wikipedia.org)
  • Pantoprazole was partially metabolized by four strains of Cunninghamella, and C. blakesleeana AS 3.153 was selected for further investigation. (unboundmedicine.com)
  • TY - JOUR T1 - Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. (unboundmedicine.com)
  • Hence, the objective is to optimize the fermentation conditions for lovastatin production by Cunninghamella blakesleeana under Solid State fermentation (SSF) condition through screening the critical factors by one factor at a time and then, optimize the factors selected from screening using statistical approaches. (researchsquare.com)
  • SSF was carried using the pure culture of Cunninghamella blakesleeana KP780148.1 with wheat bran as substrate. (researchsquare.com)
  • Screening result indicated the optimum values of the analysed parameter for the maximal production of lovastatin by Cunninghamella blakesleeana were selected. (researchsquare.com)
  • Hence, this is the first report on the optimization of critical parameters for lovastatin production by Cunninghamella blakesleeana . (researchsquare.com)
  • The metabolites were collected by two-stage fermentation of bromhexine with different strains of Cunninghamella sp. (bvsalud.org)
  • Reference standards of these four metabolites were obtained through microbial biotransformation by Cunninghamella blakesleana. (curehunter.com)
  • Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: Evidence for the presence of cytochrome P-450. (wikipedia.org)
  • Cloning and characterization of the cytochrome P450 oxidoreductase gene from the zygomycete fungus Cunninghamella. (wikigenes.org)
  • Strategic Feeding of Ammonium and Metal Ions for Enhanced GLA-Rich Lipid Accumulation in Cunninghamella bainieri 2A1," The Scientific World Journal , vol. 2014, Article ID 173574, 8 pages, 2014. (hindawi.com)
  • An unusual presentation of rhinofacial zygomycosis due to Cunninghamella sp. (nih.gov)
  • The microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153 was studied, as well as a microbial model which can be used to mimic metabolism of buflomedil in mammal was established. (bvsalud.org)
  • According to Benny and Alexopoulos, the family only contains the genus Cunninghamella. (wikipedia.org)
  • The mircrobiological transformation of progesterone by a local isolate of Cunninghamella echiiiulata using a laboratory fermentor was studied. (edu.qa)
  • All three metal ions also affected GLA production by Cunninghamella sp. (thescipub.com)
  • Her research focused on biodegradation of industry dye by employing Cunninghamella elegan biofilms as immobilized catalysis system. (ucd.ie)
  • Effects of Metal Ion Concentrations on Lipid and Gamma Linolenic Acid Production by Cunninghamella sp. (thescipub.com)
  • The effects of different concentration of MgSO 4 .7H 2 O, FeCl 3 .6H 2 O, ZnSO 4 .7H 2 O, CuSO 4 .5H 2 O and MnSO 4 .5H 2 O on lipid and GLA production by Cunninghamella sp. (thescipub.com)
  • This study reports the critical concentration of each metal ion for optimal lipid and GLA production by Cunninghamella sp. (thescipub.com)
  • We aim to screen the most efficient strain of Cunninghamella sp. (bvsalud.org)
  • CS1 maint: discouraged parameter (link) Cunninghamella at the US National Library of Medicine Medical Subject Headings (MeSH) Matruchot L. (1903). (wikipedia.org)