A plant genus of the family CUCURBITACEAE, order Violales, subclass Dilleniidae, which includes pumpkin, gourd and squash.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A creeping annual plant species of the CUCURBITACEAE family. It has a rough succulent, trailing stem and hairy leaves with three to five pointed lobes.
Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.
Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
A plant species of the family CUCURBITACEAE that is a source of TRICHOSANTHIN (a ribosomal inhibitory protein).
A family (Aphididae) of small insects, in the suborder Sternorrhyncha, that suck the juices of plants. Important genera include Schizaphis and Myzus. The latter is known to carry more than 100 virus diseases between plants.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
A large class of organic compounds having more than one PHENOL group.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Tumors or cancer of the LUNG.
A publication issued at stated, more or less regular, intervals.
Compounds containing the -SH radical.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.
Freedom of equipment from actual or potential hazards.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.
Transforming proteins encoded by erbB oncogenes from the avian erythroblastosis virus. The protein is a truncated form of the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR) whose kinase domain is constitutively activated by deletion of the ligand-binding domain.
A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.
A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.
INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.
The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.
Use of written, printed, or graphic materials upon or accompanying a food or its container or wrapper. The concept includes ingredients, NUTRITIONAL VALUE, directions, warnings, and other relevant information.
State of the body in relation to the consumption and utilization of nutrients.
A class of Echinodermata characterized by long, slender bodies.
A genus of plant viruses of the family BROMOVIRIDAE, which infect cucurbits and solanaceous plants. Transmission occurs via aphids in a non-persistent manner, and also via seeds. The type species Cucumber mosaic virus, a CUCUMOVIRUS, should not be confused with Cucumber green mottle mosaic virus, a TOBAMOVIRUS.
A satellite RNA (not a satellite virus) which has several types. Different cucumoviruses can act as helper viruses for different types.
A genus of large SEA CUCUMBERS in the family Holothuriidae possessing thick body walls, a warty body surface, and microscopic ossicles.

Two new cucurbitacin glucosides, opercurins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata). (1/12)

The structures of two new cucurbitacin glucosides designated opercurins A (1) and B (2), isolated from the fruit of Luffa operculata, have been confirmed by extensive spectroscopic investigation.  (+info)

Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. (2/12)

The aim of this study was to investigate the effects of cucurbitacin R on an experimental model of adjuvant-induced arthritis in rats. The treatment of arthritic rats with cucurbitacin R (1 mg/kg p.o. daily) modified the evolution of the clinical symptoms, whereas the histopathology of paws demonstrated a reduction in the signs of arthritis. Compared with the control group, radiography of the tibiotarsal joints of cucurbitacin R-treated rats showed a decrease in joint damage and soft tissue swelling of the footpad. The in vivo study of the expression of proinflammatory enzymes (nitric-oxide synthase-2 and cyclooxygenase-2) with the aid of the Western blot technique, and that of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E(2) by means of enzyme-linked immunosorbent assays demonstrated a clear decrease in both the enzymes and the mediators in paw homogenates. The analysis for prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes, indicated a reduction of all mediators. The expression of cyclooxygenase-2 was not modified in RAW 264.7 macrophages, whereas the expression of nitric-oxide synthase-2 was clearly diminished. Moreover, cucurbitacin R was found to inhibit signal transducer and activator of transcription 3 activation in the lymphocytes of both healthy and arthritic men. These experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents.  (+info)

Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. (3/12)

Poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and newly developed poly(ethylene oxide)-block-poly(alpha-benzyl carboxylate epsilon-caprolactone) (PEO-b-PBCL) micelles were evaluated for the solubilization and delivery of cucurbitacin I and B, poorly water soluble inhibitors of signal transducer and activator of transcription 3 (STAT3). Encapsulation of cucurbitacins in PEO-b-PCL and PEO-b-PBCL by co-solvent evaporation technique resulted in polymeric micelles <90 nm in diameter. The aqueous solubility of both derivatives increased from less than 0.05 mg/mL in the absence of the copolymer to around 0.30-0.44 and 0.65-0.68 mg/mL in the presence of 5000-5000 and 5000-24,000 PEO-b-PCL micelles, respectively. Maximum cucurbitacin solubilization was achieved with PEO-b-PBCL micelles for both derivatives. PEO-b-PCL micelles having longer PCL block were found to be more efficient in sustaining the rate of release for cucurbitacins. The anti-cancer and STAT3 inhibitory activity of polymeric micellar cucurbitacins were comparable with free drugs in B16.F10 melanoma cell line in vitro. Intratumoral injection of 1 mg/kg/day cucurbitacin I resulted in the regression of established B16.F10 mouse melanoma tumors in vivo. In comparison to free cucurbitacin I, PEO-b-PBCL micellar cucurbitacin I was found to provide comparable anti-cancer effects against B16.F10 tumors and limit drug levels in animal serum while maintaining high drug levels in tumor following intratumoral administration. The results indicate the potential of polymeric micelles as suitable vehicles for the delivery of cucurbitacin- I and B.  (+info)

Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity. (4/12)

Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).  (+info)

Differential regulation of STAT family members by glycogen synthase kinase-3. (5/12)

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Actin-aggregating cucurbitacins from Physocarpus capitatus. (6/12)

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Cucurbitacin: ancient compound shedding new light on cancer treatment. (7/12)

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Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. (8/12)

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The composition of the seeds per 100 g edible portion is: water 5.3 g, energy 2709 kJ (647 kcal), protein 30.7 g, fat 57.0 g, carbohydrate 2.3 g, crude fibre 1.3 g, Ca 100 mg, Mg 363 mg , Fe 4.0 mg, Zn 5.5 mg, niacin 2.2 mg. The composition of fresh fruits per 100 g edible portion is: water 84 g, energy 231 kJ (55 kcal), protein 1.4 g, fat 0.3 g, carbohydrate 11.7 g, fibre 1.0 g, Ca 21.4 mg, Mg 19.0 mg, P 22.4 mg, Fe 0.5 mg, Zn 0.6 mg, carotene 0.12 mg, thiamin 0.01 mg, riboflavin 0.02 mg, niacin 0.75 mg (Van den Eynden, V., Vernemmen, P. & Van Damme, P., 1992). The ripe fruits are aromatic and the pulp is rich in sugars. The fruit pulp and plant sap contain a non-volatile enzyme which curdles milk. A high percentage of the seed-oil is made up of polyunsaturated fatty acids, with a linoleic acid content of 53%. Green unripe fruits contain varying amounts of highly oxygenated tetracyclic triterpenoids, called cucurbitacins. Cucurbitacins B and D have been identified as the primary source of ...
Federal Register: September 1, 1999 (Volume 64, Number 169)] [Notices] [Page 47788-47791] >From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr01se99-95] ----------------------------------------------------------------------- ENVIRONMENTAL PROTECTION AGENCY [PF-889; FRL-6098-6] Notice of Filing a Pesticide Petition to Establish a Tolerance for Certain Pesticide Chemicals in or on Food AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: This notice announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of certain pesticide chemicals in or on various food commodities. DATES: Comments, identified by docket control number PF-889, must be received on or before October 1, 1999. ADDRESSES: Comments may be submitted by mail, electronically, or in person. Please follow the detailed instructions for each method as provided in Unit I.C. ...
The novel cucurbitacins, balsaminagenin A and B (1-2) and balsaminoside A (3) and the know cucurbitacin karavelagenin C (4), together with five new mono or diacylated derivatives (5-9) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells. Compounds 2-6 exhibited a strong activity compared with that of the positive control, verapamil. Structure-activity relationships are discussed. Moreover, in the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 2-5 synergistically enhanced the effect of the anticancer drug. Compounds 1-4 were isolated from the aerial parts of Momordica balsamina L. The structures of the compounds were established on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC and NOESY ...
Cucumbers are very hydrating (contain 96% water). Hydration is vital for healthy soft supple skin. Cucumbers have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammatory, and anti-cancer benefits. ...
i,Physocarpus malvaceus,/i, is a locally native woody shrub that grows on moist slopes and near streams in foothill to high elevation areas. The flowers have two (less commonly more) pistils as depicted above.While the large leaves are mallow-like, the plant is actually a member of the Rose... ...
Cucurbita pepo, one of the most popular edible plants, is widely used as functional food and medicinal remedies around the world, due to the presence of numerous biologically active components with interesting nutraceutical properties like carotenoids, hypoglycemic polysaccharides, minerals, pectin, polyphenols, saponins, tocopherols, vitamins, cucurbitacins, various anti-fungal proteins, essential fatty acids, essential and nonessential amino acids, and fibre. The edible round-fruited types of Cucurbita pepo are called pumpkins. Most parts of the pumpkin (fruit, flowers, and the seeds) have various health benefits including antidiabetic, anticarcinogenic, antiinflammatory, antimicrobial, antioxidant, antiparasitic, hepatoprotective, lipid-lowering, and hypotensive. This short review aims to discuss the antidiabetic, anticarcinogenic, antioxidant, antimicrobial, and antiparasitic benefits of pumpkin ...
General: A deciduous, many-branched shrub, 1-3 m tall. Young branches are smooth (glabrous) to slightly hair and somewhat angled; older branches have grayish-brown, papery bark that shreds off in long, thin layers.. Nomenclature: The name Physocarpus opulifolius (L.) Maxim. has been conserved over the earlier name, Physocarpus opulifolius Raf., which is now a rejected name (nom. rej.).. Leaves: Alternate, simple, palmately 3-lobed, and petiolate. Leaves have a broad, rounded to slightly cordate base, the three lobes are ovate to triangular, with blunt to acute tips, and crenate to coarsely toothed margins; young leaves develop lobes as they mature. Leaves are 3-7 cm long and almost as wide, dark green and paler beneath, and glabrous to slightly hairy; petioles are about 1-2 cm long.. Flowers: Showy, less than 1 cm across, with 5 white petals and a 5-lobed, green calyx; with numerous flowers arranged in rounded clusters (umbel-like corymbs). The flower stalks (pedicels) are minutely hairy and ...
Det er snålt hvordan smaken i hagen endrer seg med årene. Før likte jeg ikke gult i noen sammenhenger enten det var på blomster eller blader. Jeg er fortsatt ikke noen stor tilhenger av gule blomster, men har da noen sånn hist og pist. Men gult bladverk har jeg fått helt dilla på. I fjor kjøpte jeg flere gule thuja, og har en utrolig flott liten plante som jeg fikk som stikling for et par år siden. Det er Physocarpus opulifolius Darts Gold. Den står i skråningen og lyser som en liten sol for tiden. Jeg har bare et ankepunkt mot den, og det er at den ikke beholder den fine fargen hele sommeren. Sånn er det med noen gule hosta også, for de skifter til mere grønt utpå sommeren. Så derfor har jeg i år bestilt noen som etter sigende skal være like gule hele sesongen. Det gjenstår å se hvor gule de forblir ...
A poem every day in April (2019 - 2020) 2019 Day #1: A Fresh Start Myth of a vacation, holiday home by the sea, a detox tea, illusion of a face mask, hot bath, sacred steam, hold me. Promise of letting go, fresh start - the past falls apart. Like an orange, peel me into…
As part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) yielded four known indole alkoids. Casimirella sp (Icacinaceae) gave three new and five known diterpenoids. Pentopetia androsaemifolia (Apocynaceae) afforded one new and three known cardenolide glycosides. Physalis angulata (Solanaceae) yielded seven known physalins. Roupellina boivinnii (Apocynaceae) yielded four known and three new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae). In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed ...
Angled luffa (luffa acutangula) Click on photo to enlarge There are two species of luffa (loofah) - angled luffa (luffa acutangula) and smooth skin luffa (luffa cylindrical). This article will focus on angled luffa. I will write about smooth skin luffa in another post. Angled luffa or loofah also known as ridged skin luffa, silk…
Five species of Diabroticites with different host plant affinities produced an essentially identical array of metabolites when fed radio-labeled cucurbitacin B. All species excreted the bulk of the cucurbitacin (67.17-94.59% total dpm); permanently sequestered a small proportion of a cucurbitacin D conjugate in the hemolymph (0.98-2.76%); and apportioned the remainder between the gut, the body and the eggs (when present). Markedly different ratios between the excretory metabolites, i.e., polar vs. unmetabolized cucurbitacin, suggest that Diabrotica virgifera virgifera, a grass specialist, and Acalymma vittatum, a cucurbit specialist, have lower rates of metabolic alteration than D. undecimpunctata howardi and D. balteata which are polyphagous and D. cristata ...
The biosynthesis of cucurbitacin C has been described. Zhang et al. (2014) identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps.[4] These authors also discovered the transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. The Bi gene confers bitterness to the entire plant and is genetically associated with an operon-like gene cluster, similar to the gene cluster involved in thalianol biosynthesis in Arabidopsis. Fruit bitterness requires both Bi and the dominant Bt (Bitter fruit) gene. Nonbitterness of cultivated cucumber fruit is conferred by bt, an allele selected during domestication. Bi is a member of the oxidosqualene cyclase (OSC) gene family. Phylogenetic analysis showed that Bi is the ortholog of cucurbitadienol synthase gene CPQ in squash (Cucurbita pepo) [4] ...
Purple Finch (Haemorhous purpureus), Lights Upon Ninebark (Physocarpus opulifolius) The Purple Finch (Haemorhous purpureus, pictured above), with its raspberry-stained plumage and sweet, warbling song, is an occasional guest at my bird feeders during the winter months. With color scarce at this time of year, I am grateful for the brilliant-colored beauty and musical backdrop provided by this lovely, native bird.. The plummy-red hued, male Purple Finches are easy to spot at feeders and if you are hoping to attract them, its helpful to know that they are especially fond of black oil sunflower seeds! The female Purple Finch is mostly brown and white, with a streaky underbelly and white brow. In winter, small flocks also visit my flower beds, feasting upon seeds from perennial plants and ornamental grasses. In the landscape beyond, I sometimes spot them in the lower meadow, where they hunker down to feed within weedy wildflower remnants (learn more about this beautiful species at Cornell Lab of ...
The small GTPase Rac1 has been widely implicated in mammary tumorigenesis and metastasis. Previous studies established that stimulation of ErbB receptors in breast cancer cells activates Rac1 and enhances motility via the Rac-GEF P-Rex1. As the Jak2/Stat3 pathway has been shown to be functionally associated with ErbB receptors, we asked if this pathway could mediate P-Rex1/Rac1 activation in response to ErbB ligands. Here we found that the anticancer agent cucurbitacin I, a Jak2 inhibitor, reduced the activation of Rac1 and motility in response to the ErbB3 ligand heregulin in breast cancer cells. However, Rac1 activation was not affected by Jak2 or Stat3 RNAi, suggesting that the effect of cucurbitacin I occurs through a Jak2-independent mechanism. Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin. Subsequent analysis revealed that cucurbitacin I strongly activates RhoA and the Rho effector ROCK in breast cancer cells and induces the formation of stress fibers. ...
Dishrag gourd, smooth luffa, luff, lufa, belustra, nerua, calabaza de aristas, sponge luffa, kimput, bloostru, ghiya tori, nenwa, ta tsu kua, shui kwa, loofah, dishcloth gourd, vegetable sponge gourd, Pepinillo de San Gregorio, patola, patolang bilog, Loefahspons, Plantaardige spons, Schwammgurke, Hechima, Esponja vegetal. ...
Although different Zicam products contain different ingredients, some of the active ingredients in Zicam cold remedies are galphimia glauca, luffa operculata, sabadilla, zincum aceticum, and zincum...
Cucurbitacin B and Cucurbitacin C are the names of the compounds which cause bitterness in cucumbers. These compounds are found in all plant parts, but are concentrated in the stem end of the fruit. There is some in the blossom end, as well. Different varieties of cucumbers seem to contain more bitterness than others. You can cut off the ends to remove the bulk of the bitterness, but there will still be some under the skin of the cuke. Some people believe that if they peel a cucumber from the stem end to the blossom end, theyll remove more of the bitterness. There have been scientific studies, and the direction of peeling doesnt really make any difference in the amount of bitterness in a cucumber ...
Magnusiomyces capitatus ATCC ® 28576D-2™ Designation: Genomic DNA from Magnusiomyces capitatus strain IGC 3709 [ATCC ® 28576™] Application:
GUNA-ALLERGY T- ammonium carbonate - apis mellifera - arsenic trioxide - blatta orientalis - cupric acetate - drimia maritima bulb - epinephrine - galphimia glauca flowering top - histamine dihydrochloride - luffa operculata - manganese gluconate - onion - schoenocaulon officinale seed - sodium chloride - sus scrofa adrenal gland - sus scrofa bronchus - sus scrofa nasal mucosa - solution/ drops ...
G. fruticosus & G. physocarpus are two similar shrubby plants species of milkweed. They are commonly grown in New Zealand where they are the main hosts of the monarch butterfly caterpillar. Their tissues are full of poisonous white milky latex (sap). Ingestion of the plants leaves, stems, or the seeds in the bladder like fruit can affect the heart, breathing, central nervous system and the stomach, and may lead to death in livestock and humans. The poisonous compounds are toxic cardenolide glycosides that are specifically are heart-arresting. The sap is irritant to the skin and is extremely toxic to the eyes. The text below is courtesy of the Northern Advocate 2017. Mr Warman wanted to share the horrific experience so those with the plants were aware of the potential risks. Everyone I tell about whats happened [people] isnt aware of how toxic it is. I just want parents to know so they can just watch their children as they are very popular when it comes to monarch butterflies and learning ...
Grow your own Luffa sponge Luffa cylindrica or sponge gourd is a large annual vine that grows 30 or more in one season. It has its origin in Sou
This study was devoted to the development of pulp Luffa Cclindrica and its characterization paper (annual plant fiber of the family Cucurbitaceae). Baking at soda helps to achieve a high level of delignification (Kappa ≤ 10) and high yield (≈ 67%).The beatability stack Valley is comparable to refined wood fibers, the fibers develop a normally time with good hydrophilic properties without excessive morphological variations. The Comparing to the same level of physical properties of refining pulp Luffa cylindrica with different pulps annual plants (straw, bagasse or kenaf), obtained by different processes, shows good mechanical properties of the fibers, in addition its behavior would tend to approach more the hardwood pulps. The measured thermal conductivity on the handsheets Luffa Cylindrica was found equal to 0.112 W / m K, value being also in the rather broad range of the data of the literature on different types of pulp, between 0.1 and 0.2 W / m K.
kód: 0635 rod: Coreopsis druh: Coreopsis verticillata Moonbeam čeľaď: Asteraceae slov. názov: kráska praslenová
A. This is an excellent natural product and does not contain anti-histamine. A.Vogel Luffa Complex Drops 50ml. Buy it in Health Care and Health on Bubbles
Page contains details about hybrid polymeric micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Welcome to pinecone64 PATH~~-~~-~--~~ the path is always ready to Stroll. Did you bookmark pinecone64~~~-~~-~~~a path for extraordinary people! Ou
Our results suggest that CucB and EGCG have unique properties and may be developed as potential biopesticides for aphid control in agriculture.
Clean invigorating Luffa soap! 5 oz soap bar made with pure essential oils of Mandarin and fruity extracts and phthalate free natural fragrance ! Turmeric used for coloring ,just like our soap! DOES NOT CONTAIN HONEY - ALL VEGAN listing is for 1 loofah exfoliating bar The Loofa soap has be
Looking for online definition of Croton capitatus in the Medical Dictionary? Croton capitatus explanation free. What is Croton capitatus? Meaning of Croton capitatus medical term. What does Croton capitatus mean?
Patola also known as Luffa acutangula or sponge gourd. This commodity is popularly known as vegetable and bath sponge. I am gathering health information about this vegetable. The following are the data that I have gathered so far: 1) Analyses of the unripe fruit show it is good source of calcium and iron and an…
Cavalier-Smith,T (1998): A revised six-kingdom system of life. ,Biological Reviews 73(3), 203-266. , ,Subphylum Polychaeta, Infraphylum NOV. Operculata (Spirorbis, Serpula), ,Infraphylum NOV. Pharyngata (Nereis, Arenicola, Sabella). We should feel honoured that the great Tom Cavalier-Smith, famous for his multifarious hypotheses about the evolution and classification of the Eukaryota, has deigned to cast his eye on our little clade (or grade). For Tom, paraphyly and polyphyly are not dirty words, they give one an opportunity to revise, and revise again. So look out for his new, improved, 7 Superduper-Kingdom system in your library sometime soon. ********************************* Greg Rouse School of Biological Sciences A08 University of Sydney N.S.W. 2006 Australia gregr at bio.usyd.edu.au Tel. (02) 9351 5571 Fax (02) 9351 4119 International: 61 2 replaces 02 -- ANNELIDA Discuss = annelida at net.bio.net = talk to all members Server = biosci-server at net.bio.net = un/subscribes Archives = ...
Hydrilla verticillata is one of the most serious and troublesome aquatic weeds in the worlds waterways. Its massive spread is largely due to human activities, such as boating and fishing and the aquarium trade. It is a severe problem in several areas in the U.S.; in Florida it has infested a large percentage of the states waters. Large subsurface masses of underwater branches form that impede navigation, interfere with hydroelectric plants, clog irrigation canals, affect water supplies, and block light, displacing native plants. This species produces four distinct vegetative disseminule types, undoubtedly one of the reasons for its prodigious spread. The only known seed production is in monoecious populations in North Carolina.. ...
The Metrosideros operculata Labill., Sert. Austro-Caled. (1824) 61, group is restricted to New Caledonia and has a wide altitudinal range, mostly in shrub associations, from near sea level to about 1500 metres ...
Chinese Mallow is an annual or biennial that grow up to 1.7 m. Stem is green to purplish hairy, or hairless. Leaves are usually round in outline, 3-23 cm long, 4-25 cm broad, heart-shaped or flat at base, both surfaces hairy, usually 5 lobed. Stipules are lanceolate, 5 mm long, about 4 mm borad. Leaf-stalks are 4-24 cm long, densely velvety above. Flowers are borne in leaf axils, 2 to many, in loose or compact cluster. Flower-stalks are sometimes not visible, sparsely hairy 3-5 mm long. False sepals are linear or linear-lanceshaped 3-6 mm long, 1-1.5 mm broad, glabrescent, margin ciliate. Sepal cup is free to halfway down - sepals 5-6 mm long, 3-4 mm broad, very sparsely hairy. Petals are 7-9 mm long, purplish, hairless, clawed, slightly notched. Stamen column is 4.5 mm long. Fruit is enclosed in the sepal cup, 5-7 mm across. Mericarps are 10-12, glabrous, rugose on the margins, centrally grooved or smooth on the dorsal side, radially rugose, about 2 mm across in all directions. The plant was an ...
Biokjemiske og strukturelle analyser av glycosylated proteiner krever relativt store mengder homogen prøver. Her presenterer vi en...
Bhandari, Pamita; Kumar, Neeraj; Singh, Bikram; Kaul, Vijay K. (2007). "Cucurbitacins from Bacopa monnieri". Phytochemistry. 68 ... cucurbitacin and plantainoside B. Lansdown, R.V.; Knees, S.G.; Patzelt, A. (2013). "Bacopa monnieri". IUCN Red List of ...
Important sub-classes include sterols and cucurbitacins. Triterpenoid saponins are triterpenes which belong to the saponin ...
Cucurbitacin I (JSI-124). CHZ868 - a type II JAK2 inhibitor for use in myeloproliferative disorders and chronic myelomonocytic ... Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (March 2003). "Discovery of JSI-124 (cucurbitacin I), a selective ...
The blades of the plant contain cucurbitacins, which are poisonous to some animals, and some of them are among the bitterest ... Kupchan, S.Morris; Meshulam, Haim; Sneden, Albert T. (1978). "New cucurbitacins from Phormium tenax and Marah oreganus". ...
Cucurbitacins A-L, O-T Datiscosides, from Datisca glomerata Endecaphyllacins A and B, from roots of Hemsleya endecaphylla ... Anmol Publications, India Chen, J. C.; Chiu, M. H.; Nie, R. L.; Cordell, G. A.; Qiu, S. X. (2005). "Cucurbitacins and ...
... there are occasional reports of cucurbitacin causing illness in humans. Cucurbitacin is also used as a lure in insect traps. ... Cucurbitacin is a plant steroid present in wild Cucurbita and in each member of the family Cucurbitaceae. Poisonous to mammals ... Ingesting too much cucurbitacin can cause stomach cramps, diarrhea and even collapse. This bitterness is especially prevalent ... Tallamy, Douglas W.; Krischik, Vera A. (1989). "Variation and Function of Cucurbitacins in Cucurbita: An Examination of Current ...
The slightly bitter taste of cucumber rind results from cucurbitacins. In 2009, an international team of researchers announced ...
... s are cucurbitacins, formally derived from the triterpene hydrocarbon cucurbitane. They include: Kuguacin A Kuguacin B ...
... but also cucurbitacins, which are better known as chemical defenses in the Cucurbitaceae plant family. Cucurbitacins from ... Nielsen, Jens Kvist; Larsen, Lone Melchior; Søorensen, Hilmer (1977-01-01). "Cucurbitacin E and I in Iberis amara: Feeding ... Sachdev-Gupta, Kusum; Radke, Celia D.; Renwick, J. Alan A. (1993-08-12). "Antifeedant activity of cucurbitacins from Iberis ... Cucurbitacins from Iberis umbellata (globe candytuft) are ecdysteroid antagonists, acting on the ecdysteroid receptor of ...
Studies in rodent models have shown that several cucurbitacins isolated from tayuya may have anti-inflammatory properties and ... "Cucurbitacin IIb Exhibits Anti-Inflammatory Activity through Modulating Multiple Cellular Behaviors of Mouse Lymphocytes". PLoS ... "Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots". Planta Medica. 70 (5): 414-20. doi: ... reduce damage from arthritis.Some cucurbitacins can be made anti-rheumatic agent. "Cucurbitaceae Cayaponia tayuya". ...
... related to cucurbitacin. Karavilagenin E is soluble in methanol and ethyl acetate but insoluble in n-hexane. Balsaminapentaol ...
Toxicological analysis of the meal confirmed the presence of cucurbitacin. Dr. D.G. Hessayon (2009). The Vegetable and Herb ... However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilise edible ... can contain toxins called cucurbitacins. These are chemically classified as steroids; they defend the plants from predators, ...
Cucurbitacin b and isocucurbitacin b have been isolated from the roots. Additionally, Satake et al. (1999) isolated rosmarinic ... Bean, M. F., Antoun, M., Abramson, D., Chang, C. J., McLaughlin, J. L., & Cassady, J. M. (1985). Cucurbitacin B and ...
However, many species and also populations within species can be bitter due to cucurbitacins. Coccinia grandis is also well ...
Cucurbitacin glycosides are primarily responsible for the plants' bitterness and emetic effects. Variants of the plants' name, ...
"Convergent Evolution of Cucurbitacin Pharmacophagy in Spatially Isolated Rootworm Taxa (Coleoptera: Chrysomelidae; Galerucinae ...
The fruit and foliage are toxic due to the presence of cucurbitacin. The plant is potentially toxic to horses, sheep, cattle ...
The plant contains dendrosycin, an iso-cucurbitacin with an unusual ring formation. Described in 1882 by Isaac Bayley Balfour, ...
Changed: 'OtherNames' ('' -, 'Cucurbitacin L 2-''O''-β-,small,D,/small,-glucopyranoside'). *16:04:15 (2, 3, 4) (EDIT) User: ...
Additionally, other wild species have bitter fruit containing cucurbitacin.C. colocynthis (L.) Schrad. ex Eckl. & Zeyh., C. ...
Cucurbitacins and Cardenolides". Entomologia Experimentalis et Applicata. 24 (1): 41-54. doi:10.1111/j.1570-7458.1978.tb02755.x ...
Cucurbitacin Cucurbitin Egusi List of edible seeds List of squash and pumpkin dishes Song, Y.; Li, J.; Hu, X.; Ni, Y.; Li, Q. ( ...
Elaterium is the cucurbitacin extract used in ancient history as a purgative in folk medicine. Extracted from the juice of the ...
However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilize edible ... can contain toxins called cucurbitacins. These are steroids which defend the plants from predators, and have a bitter taste to ... as reversion to forms containing more poisonous cucurbitacin might occur. Zucchini can also be responsible for allergy caused ...
... related to cucurbitacin, isolated by C. Ramalhete and others in 2009. Cucurbalsaminol A is an amorphous powder soluble in ...
Adults can be lured to baits composed of insecticide on the cucurbitacin-rich roots of wild cucurbits. Although some natural ...
... related to cucurbitacin, isolated by C. Ramalhete and others in 2009. Balsaminepentaol is an amorphous powder soluble in ...
Other chemicals in the Caigua include triterpenoid saponins and the seeds have been reported with six cucurbitacin glycosides. ... Studies on the constituents of Cyclanthera pedata (caigua) seeds: isolation and characterization of six new Cucurbitacin ...
... related to cucurbitacin, isolated by C. Ramalhete and others in 2009. Balsaminol B is an amorphous powder soluble in methanol ...
... the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol ...
Cucurbitacin S[edit]. *Cucurbitacin S from Bryonia dioica [1]:8485. Cucurbitacin T[edit]. *Cucurbitacin T, from the fruits of ... Cucurbitacin K[edit]. *Cucurbitacin K, stereoisomer of cucurbitacin J,[9]:2 from Iberis amara [1]:70 *Cucurbitacin K 2-O-β- ... Cucurbitacin O[edit]. *Cucurbitacin O from Brandegea bigelovii [1]:73 *Cucurbitacin Q 2-O-glucoside, from Picrorhiza kurrooa [1 ... Cucurbitacin J[edit]. *Cucurbitacin J from Iberis amara [1]:69 *Cucurbitacin J 2-O-β-glucopyranoside from Trichosanthes ...
Cucurbitacin E is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the ... Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J ... cucurbitacin E inhibits the adhesion of cancer cells in type I collagen. In vitro, cucurbitacin E protects hepatocytes from ... Cucurbitacin E is an inhibitor during the S to M phase in the cell mitosis. It causes a reduction of cell multiplication.[ ...
Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.. [Rachid Chawech, Raoudha Jarraya, Cynthia Girardi, Marieke ... glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. ...
... Anne-Marie Arel- ... Anne-Marie Arel-Dubeau, Fanny Longpré, Julie Bournival, et al., "Cucurbitacin E Has Neuroprotective Properties and Autophagic ...
... Anne-Marie Arel- ... We evaluated the neuroprotective potential of cucurbitacin E (CuE), a tetracyclic triterpenoid phytosterol extracted from the ...
Plant-derived cucurbitacin B (CucB) and epigallocatechin gallate (EGCG) are known to have insecticidal and repellent activities ... Substances : Cucurbitacin B : CK(126) : AC(84), EGCG (Epigallocatechin gallate) : CK(890) : AC(0) ...
Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ... Upon cucurbitacin B treatment, upregulation of DNMT1 and obvious heavy methylation in the promoters of c-Myc, cyclin D1, and ... Hence, cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ... Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ...
Cucurbitacin B hydrate, ≥97% (HPLC) C32H46O8 · xH2O ... cucurbitacin B (Cuc B), using a galactosylated lipid, N- ... Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability.. [Wenyu Wang, Xiuli Zhao, ...
Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer ( ... Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical ...
Buy Cucurbitacin E(P) - CAS Number 18444-66-1 from LGC Standards. Please login or register to view prices, check availability ...
A new sulfated cucurbitacin, cucurbitacin B 2-sulfate (1) and a new cucurbitacin glucoside, cucurbitacin G 2-O-beta-D… Expand ... Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia. ...
Cucurbitacin I is the most toxic. The LD,INF,50,/INF, of cucurbitacin E-glycoside, one of the more effective insect feeding ... Most cucurbitacins are insoluble in water and transfer of these cucurbitacins to ground water is unlikely. The glycosylated ... The cucurbitacins occur in nature in mixtures. Cucurbitacin B [25-(acetyloxy)-2,16,20- trihydroxy-9-methyl-19-norlanosta- 5,23- ... Cucurbitacins from the buffalo gourd and zucchini squash are currently used in pesticide products. Cucurbitacins are oxygenated ...
This study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any ... In this study, we present a draft genome and a putative pathway for cucurbitacin E and I, compounds with known medicinal value ... The expression changes for cucurbitacin E and I are shown to be consistent with known responses of A. agallocha to biotic ... stress and a set of homologous genes in Arabidopsis thaliana related to cucurbitacin bio-synthesis is presented and validated ...
Cucurbitacins as Feeding and Oviposition Deterrents to Insects 496PAlterations of cellular proliferation, apoptosis and ... Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF-κB signaling ... Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in ... Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal ...
Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been. February 24, 2019. GAT ... We discovered that cucurbitacin B induced autophagy in Jurkat cells, which appeared to be a pro-survival response [10]. Also, ... Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been reported to suppress the mTORC1/ ... Intro Cucurbitacins participate in a large category of triterpenoids within Cucurbitaceae plants, and still have many ...
INDOFINE Chemical Company supplies CUCURBITACIN D with HPLC for pharmaceutical, agricultural and life science industries. We ...
INDOFINE Chemical Company supplies CUCURBITACIN I with HPLC for pharmaceutical, agricultural and life science industries. We ...
Cucurbitacin E (CuE), a natural tetracyclic triterpenoid, is an abundant member of the cucurbitacin family, which is widely ... Cucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signalling pathway ... Cucurbitacin E (CuE), a potent member of triterpenoid family isolated from plants, has been confirmed as an antitumour agent by ... Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of ...
Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma ... anti-melanoma efficiency cucurbitacin drug release in situ-forming implants (ISFIs) intratumoral injection ... The Anti-Melanoma Efficiency of the Intratumoral Injection of Cucurbitacin-Loaded Sustained Release Carriers: In Situ-Forming ... Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma ...
During the past sixty years, several cucurbitacins hav … ... Cucurbitacins as Anticancer Agents: A Patent Review. Hussain H ... Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Ito A, Chai HB, Lee D, Kardono LB, Riswan S, ... Cucurbitacins are triterpenoid compounds originally identify as the bitter components of the Cucurbit family that demonstrated ... Specifically, Cucurbitacin E (CuE), an oxygenated tetracyclic triterpenoid, has been investigated in a wider array of ...
Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin. Subsequent analysis revealed that cucurbitacin I ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ...
The aim of this study was to investigate the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) ... Cucurbitacins are mostly found in the members of the family Cucurbitaceae and are responsible for the bitter taste of cucumber ... Seeds exhibit very low concentration of cucurbitacins [2]. The diversity of cucurbitacins lies in side chain derivatives that ... Cucumis sativus belongs to Cucurbitaceae family and is known to be rich in cucurbitacins. Cucurbitacins have become interesting ...
beetles fed on squash fruit containing cucurbitacins were rejected. Moreover, even when adults did not feed on cucurbitacins, ... fruit devoid of cucurbitacins). The longevity of female A. vittatum, however, was unaffected by the presence or absence of ... Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the ... Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the ...
Synergistic effect of cucurbitacin B in combination with curcuminviaenhancing apoptosis induction and reversing multidrug ... Cucurbitacin B is a plant-derived tetracyclic triterpenoid, which has been used for a variety of cancers, especially human ... In conclusion, cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma. ... In the present study, the synergistic effect of cucurbitacin B and curcumin was studied on BEL7402/5-Fu cells in vitro and ...
Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer ... Cucurbitacin-I (JSI-124) can be found in a variety of plants that have been used for centuries as folk medicines in Asia [1-3 ... Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer ... Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic ...
Chen, J.C., Chiu, M.H., Nie, R.L., Cordell, G.A. & Qiu, S.X. 2005 Cucurbitacins and cucurbitane glycosides: Structures and ... Chen, J.C., Chiu, M.H., Nie, R.L., Cordell, G.A. & Qiu, S.X. 2005 Cucurbitacins and cucurbitane glycosides: Structures and ... One experiment evaluated cucurbitacin A from fruit of wild cucumber, whereas the second experiment only evaluated cucurbitacin ... Optimizing temperature for the retention of cucurbitacins appeared to be above 52 °C for cucurbitacin A and below 52 °C for ...
Co-administration of cucurbitacin I (250 nM) produces a significant blockade of this effect. Cucurbitacin I alone also produced ... Cucurbitacin I had no effect on basal phosphorylation of STAT3 but reduced phorphorylated p44/42 MAPK in 2 grade II meningioma ... Recently, cucurbitacin I (JSI-124), a naturally occurring tetracyclic triterpenoid compound used as folk medicines has been ... The effects of cucurbitacin I on cerebrospinal fluid stimulation of meningioma cell DNA synthesis phosphorylation/activation of ...
For our Cucurbitacin B ICN analyses we utilized the very first scans offered for every NYU subject matter. To validate our HC1 ... example apathy compulsions utilization/imitation and obsessions Cucurbitacin B behavior emerge at varied points Cucurbitacin B ... focuses on.20 21 We hypothesized that ICN analysis would identify a PSP-related network in healthy topics and that Cucurbitacin ... brainstem cerebellum and particular cortical regions.7-9 In additional patients with PSP pathology cognitive or Cucurbitacin B ...
3. Cucumbers are rich in cucurbitacin. Cucumbers contain high levels of cucurbitacin, a class of plant compounds. Cucurbitacin ... A review by Qassim University concluded that cucurbitacins may help prevent cancer by stopping cancerous cells from reproducing ...
  • Cucurbitacin is any of a class of biochemical compounds that some plants - notably members of the family Cucurbitaceae , which includes the common pumpkins and gourds - produce and which function as a defence against herbivores . (wikipedia.org)
  • In this study, we present a draft genome and a putative pathway for cucurbitacin E and I, compounds with known medicinal value, from in vitro Aquilaria agallocha agarwood. (biomedcentral.com)
  • We inferred a putative pathway for cucurbitacin E and I from the genomic and transcriptomic data in order to better understand these important medicinal compounds in agarwood. (biomedcentral.com)
  • Cucurbitacins are triterpenoid compounds originally identify as the bitter components of the Cucurbit family that demonstrated several pro-survival activities in various model of cellular decay. (nih.gov)
  • Cucumbers contain high levels of cucurbitacin, a class of plant compounds. (runnersworld.com)
  • Cucurbitacin is what gives the cucumber its bitter flavour, and is also one of the most researched plant compounds produced by it,' says Twist. (runnersworld.com)
  • Examples include a group of compounds called cucurbitacins, found in melon and cucumbers, and propylthiouracil in broccoli. (khymos.org)
  • Cucurbitacins are a class of natural compounds known for their numerous ă potential pharmacological effects. (univ-lorraine.fr)
  • A hybrid scaffold: Molecular docking studies resulted in the design of hybrid compounds containing the α,β-unsaturated ketone of cucurbitacin D, a triterpene natural product, and an estrone core, along with a Δ 9,11 olefin. (elsevier.com)
  • When evaluated in A-375 mutant B-Raf cells, compounds with this combination of cucurbitacin-like and steroidal features exhibited potent inhibition of phosphorylated extracellular-signal-regulated kinase (ERK). (elsevier.com)
  • This bitterness comes from cucurbitacins, a class of compounds found in members of the Cucurbitaceae family, such as squash, zucchini, and gourds ( 13 , 14 ). (healthline.com)
  • This indicates that it's high in cucurbitacins, which are compounds that can be toxic. (healthline.com)
  • Cucumbers contain naturally occurring compounds known as cucurbitacins. (budget101.com)
  • Cucurbitacins are compounds and triterpene phytonutrients that may inhibit cancer growth and risk. (drcolbert.com)
  • Cucurbitacins may be a taste deterrent in plants foraged by some animals and in some edible plants preferred by humans, like cucumbers . (wikipedia.org)
  • In the case of cucumbers, they are called cucurbitacins. (palmbeachpost.com)
  • The bitter taste, in fact, was the telltale clue: Plants in the family Cucurbitaceae (squash, pumpkins, zucchini, cucumbers, melons and gourds) produce a bitter toxin - cucurbitacin - as a defense mechanism against insects, said Dr. Tao Sheng Kwan-Gett in the latest issue of "Epi-Log," a communicable disease and epidemiology newsletter produced by Public Health - Seattle & King County. (seattletimes.com)
  • To ensure that your homegrown cucumbers aren't high in bitter cucurbitacins, always plant them with sunflowers. (budget101.com)
  • Growth inhibitory effect of cucurbitacin B on breast cancer cells was assessed by MTT assay and colony formation assay. (greenmedinfo.com)
  • However, Rac1 activation was not affected by Jak2 or Stat3 RNAi, suggesting that the effect of cucurbitacin I occurs through a Jak2-independent mechanism. (aspetjournals.org)
  • Interestingly, disruption of the RhoA-ROCK pathway prevented the inhibitory effect of cucurbitacin I on Rac1 activation by heregulin. (aspetjournals.org)
  • The ROS scavenger N-Acetyl L-cysteine (NAC) and the mitochondrial anti-oxidant Mito-TEMPO rescued the inhibitory effect of cucurbitacin I on Rac1 activation. (aspetjournals.org)
  • Moreover, they established that the inhibitory effect of cucurbitacin I on Rac1 activity involves the alteration of the balance between Rho and Rac. (aspetjournals.org)
  • In the present study, the synergistic effect of cucurbitacin B and curcumin was studied on BEL7402/5-Fu cells in vitro and BEL7402 tumor-bearing mice in vivo. (ovid.com)
  • Some studies indicate the inhibition of Jak/sign transducer and activator of transcription 3 (STAT3) signaling becoming the ISG15 mechanism in charge of inhibitory ramifications of cucurbitacins on tumor cells [2], while some support the idea that it's the fast disruption from the actin cytoskeleton by cucurbitacins becoming in charge of their anticancer actions [3, 4]. (exposed-skin-care.net)
  • Apart from their actions within the actin cytoskeleton and Jak/STAT3 signaling, cucurbitacins possess recently been proven to inhibit the mTORC1 activity in tumor cells [9]. (exposed-skin-care.net)
  • Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia. (biomedcentral.com)
  • Recently, cucurbitacin I (JSI-124), a naturally occurring tetracyclic triterpenoid compound used as folk medicines has been found to have cytoxic and anti-proliferative properties in several malignancies thru inhibition of activator of transcription (STAT3) activation. (biomedcentral.com)
  • The effects of cucurbitacin I on cerebrospinal fluid stimulation of meningioma cell DNA synthesis phosphorylation/activation of JAK1, STAT3, pMEK1/2, p44/42MAPK, Akt, mTOR, Rb and caspase 3 activation were analyzed in human leptomeningeal and meningioma cells. (biomedcentral.com)
  • Cucurbitacin I had no effect on basal STAT3 phosphorylation but co-administration with cerebrospinal fluid blocked cerebrospinal fluid stimulation of STAT3 phosphorylation in each. (biomedcentral.com)
  • In the grade I meningiomas, cerebrospinal fluid stimulated phosphorylation of STAT3 and decreased MEK1/2 and cucurbitacin I had no effect on basal STAT3, p44/42MAPK, Akt, JAK1, mTOR, or Rb phosphorylation. (biomedcentral.com)
  • Cucurbitacin I had no effect on basal phosphorylation of STAT3 but reduced phorphorylated p44/42 MAPK in 2 grade II meningioma cells lines. (biomedcentral.com)
  • Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. (adooq.com)
  • STAT3 was inhibited with 500 nM cucurbitacin I, JAK/STAT3 with 280 nM ruxolitinib. (jci.org)
  • Cucurbitacin-I, the compound that led scientists to STAT3, is a plant steroid. (bio-medicine.org)
  • After the successful robotic test of cucurbitacin-I, researchers showed that STAT3, which turns on and off the activity of a number of genes, is unusually active in NF1 tumor cells. (bio-medicine.org)
  • We evaluated the neuroprotective potential of cucurbitacin E (CuE), a tetracyclic triterpenoid phytosterol extracted from the Ecballium elaterium (Cucurbitaceae), using a known cellular model of PD, NGF-differentiated PC12. (hindawi.com)
  • Intro Cucurbitacins participate in a large category of triterpenoids within Cucurbitaceae plants, and still have many biological actions, including anticancer, anti-inflammatory, anti-diabetic, and hepatoprotective actions [1]. (exposed-skin-care.net)
  • Cucurbitacins are mostly found in the members of the family Cucurbitaceae and are responsible for the bitter taste of cucumber. (biomedcentral.com)
  • Cucumis sativus belongs to Cucurbitaceae family and is known to be rich in cucurbitacins. (biomedcentral.com)
  • Both adults and larvae of E. admirabilis, which mainly feeds on the genus Trichosanthes (Cucurbitaceae), were strongly stimulated to feed by these cucurbitacins, especially by cucurbitacin E-glucoside. (elsevier.com)
  • Cucurbitacin content of cotyledons of Cucurbitaceae cultivars as estimated by Diabroticite feeding on TLC plates developed from standard chloroform extracts. (ncsu.edu)
  • However, these effects were mostly associated with eating members of the Cucurbitaceae family that contain high amounts of cucurbitacins, such as certain gourds - not commercially grown varieties ( 16 ). (healthline.com)
  • Ferguson JE, Metealf ER, Metealf RL, Rhodes AM (1983) Influence of cucurbitacin content in cotyledons of Cucurbitaceae cultivars upon feeding behavior of Diabroticina beetles (Coleoptera: Chrysomelidae). (springer.com)
  • Intake of foods high in cucurbitacins has been linked to poisoning and death in sheep and cattle. (healthline.com)
  • abstract = "Feeding responses of adults and larvae of Epilachna admirabilis, E. boisduvali, E. vigintioctomaculata, and E. vigintioctopunctata to four cucurbitacins (B, E, I and E-glucoside) were investigated. (elsevier.com)
  • Cucurbitacins impart a bitter taste in plant foods such as cucumber, zucchini, melon and pumpkin. (wikipedia.org)
  • The consumption of bitter tasting zucchini prior to the onset of symptoms implicated cucurbitacins. (ncsu.edu)
  • Analysis of a freeze-dried sample of very bitter zucchini provided to us by the Redlands Horticultural Research Station determined beyond question that cucurbitacins were present. (ncsu.edu)
  • This remarkably high level of cucurbitacin is comparable to that of many wild cucurbits and undoubtedly could account not only for the bitter taste of the zucchini cultivar but the symptoms of poisoning reported in Australia. (ncsu.edu)
  • The cucurbitacins seem clearly to have arisen by coevolutionary selection as intensely bitter substances effective as feeding deterrents to herbivores. (ncsu.edu)
  • That said, if you bite into zucchini and it tastes extremely unpleasant and bitter, it's best to spit it out and dispose of the entire fruit to avoid the risk of cucurbitacin toxicity. (healthline.com)
  • The higher the level of cucurbitacins, the more bitter the cucumber will taste. (budget101.com)
  • Cucurbitacins are the bitter property. (simplefit.org)
  • Cucurbits can contain cucurbitacin, a toxic compound that gives off a bitter taste. (yahoo.com)
  • Cucurbitacins are chemically classified as steroids , formally derived from cucurbitane , a triterpene hydrocarbon -specifically, from the unsaturated variant cucurbita-5-ene , or 19-(10→9β)- abeo -10α-lanost-5-ene. (wikipedia.org)
  • Phylogenetic analysis showed that Bi is the ortholog of cucurbitadienol synthase gene CPQ in squash (Cucurbita pepo) The cucurbitacins include: Cucurbitacin A found in some species of Cucumis Pentanorcucurbitacin A, or 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one C 25H 40O 2, white powder Cucurbitacin B from Hemsleya endecaphylla (62 mg/72 g) and other plants (e.g. (wikipedia.org)
  • The 2-O-β-D-glucopyranosides of cucurbitacins K and L can be extracted with ethanol from fruits of Cucurbita pepo cv dayangua. (wikipedia.org)
  • Mean lifespans for D. balteata and D. v. virgifera, and male A. vittatum decreased significantly with continuous feeding on Cucurbita fruit containing cucurbitacins (vs. fruit devoid of cucurbitacins). (illinois.edu)
  • The five major cucurbitacins of Cucurbita -B, D, E, I and E-glycoside can be separated by HPLC (4). (ncsu.edu)
  • Cucurbitacin contents and Diabroticite feeding upon Cucurbita spp. (ncsu.edu)
  • A common feature of the preference of this group of beetles for cucurbits is the presence of the oxygenated tetracyclic triterpenoid cucurbitacins that act as kairomones promoting arrest and compulsive feeding. (ncsu.edu)
  • Cucurbitacin E is a biochemical compound from the family of cucurbitacins. (wikipedia.org)
  • With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro. (ladometer.com)
  • Combination of these cucurbitacin-like features resulted in a compound with an enhanced biological profile against the A-375 mutant B-Raf cell line, in regards to their cytotoxicity and inhibitory activity toward phosphorylated extracellular-signal-regulated kinase (ERK). (elsevier.com)
  • Pumpkin seeds contain a compound called cucurbitacin. (medicalnewstoday.com)
  • Cucurbitacin: ancient compound shedding new light on cancer treatment. (whfoods.com)
  • Its antioxidant and free-radical scavenging properties were measured by the ability of cucurbitacin glycoside combination (CGC), a combination of cucurbitacin B and E glycosides, to reduce ABTS cation to its original form and also the capacity to inhibit MDA formation originated in the oxidation of linoleic acid. (wikipedia.org)
  • The results indicated that cucurbitacin B could inhibit cell growth in breast cancer cells. (greenmedinfo.com)
  • It has been well documented that cucurbitacins inhibit growth and proliferation in various cancer cells via cell cycle arrest, and induction of apoptosis [ 9 ]. (portlandpress.com)
  • Audier HE, Das BC (1966) Mass spectrometry of tetracyclic triterpenes, Part I. The cucurbitacin group. (springer.com)
  • These include triterpenes and cucurbitacin R, B, D. Kutkin is one the very important chemical contain kutkoside and iridoid glycoside like picrosides I, II, and III. (planetayurveda.com)
  • 2014) identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. (wikipedia.org)
  • The thermostable cucurbitacin A and B from mature fruit of wild cucumber ( Cucumis myriocarpus ) and wild watermelon ( Cucumis africanus ), respectively, are used in product development for various industries. (ashs.org)
  • The objective of this study, therefore, was to determine the relative effects of increasing drying temperatures above the 52 °C standard on concentrations of cucurbitacin A and B in fruit of wild cucumber and wild watermelon. (ashs.org)
  • In conclusion, the compromise temperature of 52 °C for preserving fruit pieces in wild cucumber and wild watermelon from decay should also be viewed as the optimum temperature for preserving cucurbitacin A and B. (ashs.org)
  • However, when fruit pieces of the wild cucumber and wild watermelon were dried within the recommended range, most of the cucurbitacin materials were lost to decay, with a blue, bluish-green, or olive green colors, surrounded by white mycelium and a band of water-soaked tissues that characterize P. simplicissimum infection. (ashs.org)
  • Sunflowers release an enzyme called elastase which naturally reduces the amount of cucurbitacins within the cucumber. (budget101.com)
  • Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells. (nih.gov)
  • The aim of this study was to investigate the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) concentration in different tissues of Cucumis sativus . (biomedcentral.com)
  • Constituents of the colocynth fruit and leaves (Citrullus colocynthis) include cucurbitacins. (wikipedia.org)
  • Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. (wikipedia.org)
  • Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. (sigmaaldrich.com)
  • Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. (sigmaaldrich.com)
  • Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia. (semanticscholar.org)
  • Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya . (rain-tree.com)
  • Cucurbitacin B (Cuc B) is a natural triterpenoid with potent anticancer activities while its effect on metastasis remains unclear. (bvsalud.org)
  • Cucurbitacin E (CuE) is a triterpenoid with potent anticancer activities while the underlying mechanisms remain elusive. (umac.mo)
  • Chan JC, Chiu MH, Nie RL, Cordel GA, Qiu SX (2005) Cucurbitacins and cucurbitane glycosides: structures and biological activities. (springer.com)
  • Cucurbitacins and flavone C-glycosides from Cayaponia tayuya. (rain-tree.com)
  • These are pikuroside, phenol glycosides, veronicosides, 4-hydroxy-3-methoxy acetophenone and cucurbitacin glycosides. (planetayurveda.com)
  • Cucurbitacin E is an inhibitor during the S to M phase in the cell mitosis. (wikipedia.org)
  • Here we found that the anticancer agent cucurbitacin I, a Jak2 inhibitor, reduced the activation of Rac1 and motility in response to the ErbB3 ligand heregulin in breast cancer cells. (aspetjournals.org)
  • Cucurbitacins can disrupt the actin cytoskeleton quickly, resulting in a designated cell deformation, followed from the activation of many stress-sensing signaling pathways [3, 5]. (exposed-skin-care.net)
  • Latest function indicated that cucurbitacins may focus on cofilin [6, 7], a crucial regulator of actin dynamics, therefore harming the actin cytoskeleton. (exposed-skin-care.net)
  • Oddly enough, cofilin-actin rods had been shaped in cells treated with cucurbitacin B and such pole formation depends on the over-activation of cofilin [8]. (exposed-skin-care.net)
  • The natural product cucurbitacin E inhibits depolymerization of actin filaments. (ox.ac.uk)
  • We report that the natural product cucurbitacin E inhibits actin depolymerization and show that its mechanism of action is different from jasplakinolide. (ox.ac.uk)
  • In assays using pure fluorescently labeled actin, cucurbitacin E specifically affects depolymerization without affecting polymerization. (ox.ac.uk)
  • It inhibits actin depolymerization at substoichiometric concentrations up to 1:6 cucurbitacin E:actin. (ox.ac.uk)
  • Cucurbitacin E specifically binds to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin). (ox.ac.uk)
  • On the basis of its compatibility with phalloidin staining, we show that cucurbitacin E occupies a different binding site on actin filaments. (ox.ac.uk)
  • Using loss of fluorescence after localized photoactivation, we found that cucurbitacin E inhibits actin depolymerization in live cells. (ox.ac.uk)
  • Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis. (ox.ac.uk)
  • citation needed] In vitro, cucurbitacin E inhibits the adhesion of cancer cells in type I collagen. (wikipedia.org)
  • Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. (wikipedia.org)
  • Lastly, we found that RhoA activation by cucurbitacin I is mediated by reactive oxygen species (ROS). (aspetjournals.org)
  • Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells. (whfoods.com)
  • The bitterness comes from cucurbitacin, which helps the plant to ward off herbivores. (sciencemag.org)
  • Cucurbitacins have been bred out of cultivated fruit but are typically present in large amounts in wild cucurbits. (ncsu.edu)
  • citation needed] Cucurbitacin possesses dose-dependent anti-inflammatory activity related to its inhibition of nitric oxide (an RNS) production in macrophages without affecting the viability of these cells. (wikipedia.org)
  • Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus. (rain-tree.com)
  • Cucurbitacins are under basic research for their biological properties, including toxicity and potential pharmacological uses in development of drugs for inflammation, cancer, cardiovascular diseases, and diabetes, among others. (wikipedia.org)
  • Almost 100% of the cells were apoptotic as observed by ă DNA fragmentation (TUNEL assay) after 12 h with cucurbitacins I and D (1 ă mu M) and cucurbitacin E (10 mu M). In terms of IC50 values, ă cucurbitacins I and E presented a higher toxicity compared to that of ă cucurbitacin D (MTT assay). (univ-lorraine.fr)
  • Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been reported to suppress the mTORC1/p70S6K pathway also to induce autophagy. (exposed-skin-care.net)
  • Significantly, we while others discovered that cucurbitacins could induce a powerful macroautophagy (hereafter known as autophagy) response in lots of cell types. (exposed-skin-care.net)
  • We discovered that cucurbitacin B induced autophagy in Jurkat cells, which appeared to be a pro-survival response [10]. (exposed-skin-care.net)
  • These same doses had been useful for the additional two cell lines (MCF7 and DU145) as CuE got similar influence on them (S1A and S1B Fig). Open up in another windowpane Fig 1 Autophagy induction by cucurbitacin E (CuE). (exposed-skin-care.net)
  • Cucurbitacin e induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells[J]. Chemico-Biological Interactions,2016,253:1. (umac.mo)
  • Ma G..,Luo W..,Lu J..,Ma D.-L..,Leung C.-H..,...&Chen X..(2016).Cucurbitacin e induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells. (umac.mo)
  • The transcripts discovered to be related to the cucurbitacin pathway, were validated through qRT-PCR. (biomedcentral.com)
  • have now worked out the biosynthetic pathway of cucurbitacin. (sciencemag.org)
  • Gutmann says cucurbitacin-I is likely too toxic to be suitable for use in clinical trials at this time. (bio-medicine.org)
  • Cucurbitacin B has antiproliferative activity against various human breast cancer cells, but the molecular mechanism is not completely understood. (greenmedinfo.com)
  • Objective To study the mechanism of cucurbitacin B (CuB) underlying pressure over load-induced myocardial fibrosis . (bvsalud.org)
  • Cucurbitacin E anti-inflammatory activities are proved in vivo and in vitro. (wikipedia.org)
  • Anti-angiogenesis property of cucurbitacin E was demonstrated in vitro but also in vivo in a chick embryo chorioallantoic membrane and in a mouse corneal angiogenesis model. (wikipedia.org)
  • This study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any species of Aquilaria. (biomedcentral.com)
  • Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets. (nih.gov)
  • Cucurbitacins B and I, and derivatives of cucurbitacins B, D and E, can be extracted with methanol from dried tubers of Hemsleya endecaphylla. (wikipedia.org)
  • Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives. (rain-tree.com)
  • This is a sign of high concentrations of cucurbitacins, which may be harmful. (healthline.com)
  • During the past sixty years, several cucurbitacins have been isolated from a number of cucurbitaceous species, amongst others. (nih.gov)
  • Males of four Diabroticite species consumed an average of 27.4% more artificial diet after the incorporation of 0.5 mg cucurbitacin D per g fwt diet whereas female consumption increased only 5.0% on the average. (illinois.edu)
  • Four species of Diabroticites were shown for the first time to sequester cucurbitacins. (illinois.edu)
  • Larvae of this species were stimulated to feed by all four cucurbitacins, especially by cucurbitacin I, and adults were stimulated to feed by cucurbitacin B only. (elsevier.com)
  • Abe, M & Matsuda, K 2000, ' Feeding responses of four phytophagous lady beetle species (Coleoptera: Coccinellidae) to cucurbitacins and alkaloids ', Applied Entomology and Zoology , vol. 35, no. 2, pp. 257-264. (elsevier.com)
  • A well established bioassay technique using TLC and Diabroticite beetles showed an R f value corresponding to Cucurbitacin E-glycoside (Figure 1) (3). (ncsu.edu)
  • Cucurbitacins as kairomones for diabroticite beetles. (ncsu.edu)
  • citation needed] As cucurbitacin E doesn't affect normal human liver cells, it may have therapeutic potential and effective treatment for a variety of inflammation mediated diseases. (wikipedia.org)
  • Subsequent analysis revealed that cucurbitacin I strongly activates RhoA and the Rho effector ROCK in breast cancer cells and induces the formation of stress fibers. (aspetjournals.org)
  • Firstly, curcumin synergistically enhanced the apoptosis of BEL7402/5-Fu cells induced by cucurbitacin B in the optimal mass ratio of 2:1 (cucurbitacin B:curcumin). (ovid.com)
  • A review by Qassim University concluded that cucurbitacins may help prevent cancer by stopping cancerous cells from reproducing. (runnersworld.com)
  • Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. (rain-tree.com)
  • Upon cucurbitacin B treatment, upregulation of DNMT1 and obvious heavy methylation in the promoters of c-Myc, cyclin D1, and survivin, which consequently downregulated the expression of all these oncogenes, were observed. (greenmedinfo.com)
  • Additional studies are warranted to evaluate the effects of cucurbitacin I on meningiomas in vivo. (biomedcentral.com)
  • While all beetles fed on an artificial pollen diet with no cucurbitacins were readily consumed by Chinese praying mantids, a significant proportion of adult Diabrotica spp. (illinois.edu)
  • beetles fed on squash fruit containing cucurbitacins were rejected. (illinois.edu)
  • The purpose of this work was to ă compare the cytotoxicity of three cucurbitacins I, D, E on the ă chondrosarcoma SW 1353 cancer cell line and to investigate their ă biotransformation in man. (univ-lorraine.fr)
  • Cucurbitacins I and D showed a very strong ă cytotoxicity, which was higher than that of cytochalasin D, used as a ă drug reference. (univ-lorraine.fr)
  • Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. (rain-tree.com)
  • In laboratory research , cucurbitacins have cytotoxic properties and are under study for their potential biological activities. (wikipedia.org)
  • Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J, K and L. It is being investigated for its potential biological effects. (wikipedia.org)
  • Ahmed, MS , Kopel, LC & Halaweish, FT 2014, ' Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as B-Raf inhibitors ', ChemMedChem , vol. 9, no. 7, pp. 1361-1367. (elsevier.com)
  • Halaweish, Fathi T. / Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as B-Raf inhibitors . (elsevier.com)
  • This study shows that ă cucurbitacins I, D and E present a potent cytotoxic activity toward the ă chondrosarcoma SW 1353 cell line and are metabolized as sulfate and ă glucuronide conjugates. (univ-lorraine.fr)
  • Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the oncogenic activation. (greenmedinfo.com)
  • In this study, we explore the influence of cucurbitacin B fromon the methylation status at the promoter of oncogenes c-Myc, cyclin D1, and survivin in breast cancer cell lines. (greenmedinfo.com)
  • Cucurbitacin E (CuE), a potent member of triterpenoid family isolated from plants, has been confirmed as an antitumour agent by inhibiting proliferation, migration and metastasis in diverse cancer. (portlandpress.com)
  • Alghasham AA (2013) Cucurbitacin-a promising target for cancer therapy. (springer.com)
  • Cucurbitacin E was readily hydrolyzed by ă human hepatic microsomes, leading to cucurbitacin I (K-m 22 mu M, V-max ă 571 nmol/mg proteins/min). (univ-lorraine.fr)
  • Cucurbitacin E glycoside has demonstrated antioxidant and free-radical scavenging properties. (wikipedia.org)
  • Several other cucurbitacins have been found in plants. (wikipedia.org)
  • Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages. (rain-tree.com)
  • Cucurbitacin E, An Experimental Lead Triterpenoid With Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. (nih.gov)