Cucurbita: A plant genus of the family CUCURBITACEAE, order Violales, subclass Dilleniidae, which includes pumpkin, gourd and squash.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Cucumis sativus: A creeping annual plant species of the CUCURBITACEAE family. It has a rough succulent, trailing stem and hairy leaves with three to five pointed lobes.Cucurbitacins: Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.Intramolecular Transferases: Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.TriterpenesFruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Pesticides: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.United States Environmental Protection Agency: An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.Equipment Safety: Freedom of equipment from actual or potential hazards.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Lung Neoplasms: Tumors or cancer of the LUNG.Trichosanthes: A plant species of the family CUCURBITACEAE that is a source of TRICHOSANTHIN (a ribosomal inhibitory protein).Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Sulfhydryl Compounds: Compounds containing the -SH radical.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.Beetles: INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.IllinoisInsect Control: The reduction or regulation of the population of noxious, destructive, or dangerous insects through chemical, biological, or other means.Oncogene Proteins v-erbB: Transforming proteins encoded by erbB oncogenes from the avian erythroblastosis virus. The protein is a truncated form of the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR) whose kinase domain is constitutively activated by deletion of the ligand-binding domain.Neuregulin-1: A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.Receptor, erbB-3: A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.rho-Associated Kinases: A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Molecular Mechanisms of Pharmacological Action: Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.Angiotensin Amide: The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.Sesquiterpenes, Eudesmane: SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.Gymnema sylvestre: A plant species of the genus GYMNEMA that contains gymnemic acid (triterpene SAPONINS) which affects blood sugar level, and gurmarin protein. The common name of Gurmar should not be confused with Guar (CYAMOPSIS).Cyclohexanes: Six-carbon alicyclic hydrocarbons.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Spain: Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.Schools, Health Occupations: Schools which offer training in the area of health.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Cucurbitaceae: The gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.Flowers: The reproductive organs of plants.Madagascar: One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)Pollination: The transfer of POLLEN grains (male gametes) to the plant ovule (female gamete).Placentation: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.Annonaceae: The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Tanacetum parthenium: An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.Antimitotic Agents: Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.Intermediate Filaments: Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus.Vimentin: An intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it serves a structural function in the cytoplasm. MW 52,000.Microtubules: Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
Two new cucurbitacin glucosides, opercurins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata). (1/12)The structures of two new cucurbitacin glucosides designated opercurins A (1) and B (2), isolated from the fruit of Luffa operculata, have been confirmed by extensive spectroscopic investigation. (+info)
Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. (2/12)The aim of this study was to investigate the effects of cucurbitacin R on an experimental model of adjuvant-induced arthritis in rats. The treatment of arthritic rats with cucurbitacin R (1 mg/kg p.o. daily) modified the evolution of the clinical symptoms, whereas the histopathology of paws demonstrated a reduction in the signs of arthritis. Compared with the control group, radiography of the tibiotarsal joints of cucurbitacin R-treated rats showed a decrease in joint damage and soft tissue swelling of the footpad. The in vivo study of the expression of proinflammatory enzymes (nitric-oxide synthase-2 and cyclooxygenase-2) with the aid of the Western blot technique, and that of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E(2) by means of enzyme-linked immunosorbent assays demonstrated a clear decrease in both the enzymes and the mediators in paw homogenates. The analysis for prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes, indicated a reduction of all mediators. The expression of cyclooxygenase-2 was not modified in RAW 264.7 macrophages, whereas the expression of nitric-oxide synthase-2 was clearly diminished. Moreover, cucurbitacin R was found to inhibit signal transducer and activator of transcription 3 activation in the lymphocytes of both healthy and arthritic men. These experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents. (+info)
Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. (3/12)Poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and newly developed poly(ethylene oxide)-block-poly(alpha-benzyl carboxylate epsilon-caprolactone) (PEO-b-PBCL) micelles were evaluated for the solubilization and delivery of cucurbitacin I and B, poorly water soluble inhibitors of signal transducer and activator of transcription 3 (STAT3). Encapsulation of cucurbitacins in PEO-b-PCL and PEO-b-PBCL by co-solvent evaporation technique resulted in polymeric micelles <90 nm in diameter. The aqueous solubility of both derivatives increased from less than 0.05 mg/mL in the absence of the copolymer to around 0.30-0.44 and 0.65-0.68 mg/mL in the presence of 5000-5000 and 5000-24,000 PEO-b-PCL micelles, respectively. Maximum cucurbitacin solubilization was achieved with PEO-b-PBCL micelles for both derivatives. PEO-b-PCL micelles having longer PCL block were found to be more efficient in sustaining the rate of release for cucurbitacins. The anti-cancer and STAT3 inhibitory activity of polymeric micellar cucurbitacins were comparable with free drugs in B16.F10 melanoma cell line in vitro. Intratumoral injection of 1 mg/kg/day cucurbitacin I resulted in the regression of established B16.F10 mouse melanoma tumors in vivo. In comparison to free cucurbitacin I, PEO-b-PBCL micellar cucurbitacin I was found to provide comparable anti-cancer effects against B16.F10 tumors and limit drug levels in animal serum while maintaining high drug levels in tumor following intratumoral administration. The results indicate the potential of polymeric micelles as suitable vehicles for the delivery of cucurbitacin- I and B. (+info)
Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity. (4/12)Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%). (+info)
Differential regulation of STAT family members by glycogen synthase kinase-3. (5/12)(+info)
Actin-aggregating cucurbitacins from Physocarpus capitatus. (6/12)(+info)
Cucurbitacin: ancient compound shedding new light on cancer treatment. (7/12)(+info)
Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. (8/12)(+info)
... R is actually 23,24-dihydrocucurbitacin D. Cucurbitacin S from Bryonia dioica Cucurbitacin T, from the fruits of ... Cucurbitacin H, stereoisomer of cucurbitacin G, from roots of Wilbrandia ebracteata Cucurbitacin I (elatericin B) from Hemsleya ... Cucurbitacin K, stereoisomer of cucurbitacin J, from Iberis amara Cucurbitacin K 2-O-β-glucopyranoside from Trichosanthes ... Cucurbitacins B and I, and derivatives of cucurbitacins B, D and E, can be extracted with methanol from dried tubers of ...
... is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the ... Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J ... Cucurbitacin E inhibits the adhesion of cancer cells in type I collagen . Cucurbitacin-E protects hepatocytes from CCl4 (carbon ... Cucurbitacin E is an important inhibitor during the S to M phase in the cell mitosis. It causes a reduction of cell ...
... is a plant steroid with anticancer activity. Cucurbitacin D induces growth inhibition, cell cycle arrest, and ...
In enzymology, a cucurbitacin Delta23-reductase (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction 23,24- ... This enzyme is also called NAD(P)H: cucurbitacin B Delta23-oxidoreductase. It employs one cofactor, manganese. Schabort JC, ... Schabort JC, Potgieter DJ, de Villiers V (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. I. Assay methods, ... Potgieter DJ (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. II Cofactor requirements, enzyme kinetics, ...
Cucurbitacins from Bacopa monnieri. Phytochemistry 2007. Deepak, M; Sangli, GK; Arun, PC; Amit, A (2005). "Quantitative ... cucurbitacin and plantainoside B. The constituent most studied has been bacoside A, which was found to be a blend of bacoside ...
Important sub-classes include sterols and cucurbitacins. Triterpenoid saponins are triterpenes which belong to the saponin ...
Janus kinase inhibitor
Cucurbitacin I (JSI-124). CHZ868 - a type II JAK2 inhibitor for use in myeloproliferative disorders and chronic myelomonocytic ... Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (March 2003). "Discovery of JSI-124 (cucurbitacin I), a selective ...
"New cucurbitacins from Phormium tenax and Marah oreganus". Phytochemistry. 17: 767-769. doi:10.1016/S0031-9422(00)94223-7. C. ... The blades of the plant contain cucurbitacins, which are poisonous to some animals, and some of them are among the bitterest ...
Cucurbitacins A-L, O-T Datiscosides, from Datisca glomerata Endecaphyllacins A and B, from roots of Hemsleya endecaphylla ... Anmol Publications, India Chen, J. C.; Chiu, M. H.; Nie, R. L.; Cordell, G. A.; Qiu, S. X. (2005). "Cucurbitacins and ...
This plant, and especially its fruit, is poisonous, containing cucurbitacins. In the ancient world it was considered to be an ... Attard, E. G.; Scicluna-Spiteri, A (2001). "Ecballium elaterium: An in vitro source of cucurbitacins". Fitoterapia. 72 (1): 46- ...
The slightly bitter taste of cucumber rind results from cucurbitacins. In 2014, world production of cucumbers and gherkins was ...
... s are cucurbitacins, formally derived from the triterpene hydrocarbon cucurbitane. They include: Kuguacin A Kuguacin B ...
Studies in rodent models have shown that several cucurbitacins isolated from tayuya may have anti-inflammatory properties[non- ... "Cucurbitacin IIb Exhibits Anti-Inflammatory Activity through Modulating Multiple Cellular Behaviors of Mouse Lymphocytes". PLoS ... "Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots". Planta Medica. 70 (5): 414-20. doi: ...
Additionally, other wild species have bitter fruit containing cucurbitacin. C. colocynthis (L.) Schrad. ex Eckl. & Zeyh., C. ...
List of edible seeds Cucurbitacin Cucurbitin Egusi Song, Y.; Li, J.; Hu, X.; Ni, Y.; Li, Q. (2011). "Structural ...
... related to cucurbitacin. Karavilagenin E is soluble in methanol and ethyl acetate but insoluble in n-hexane. Balsaminapentaol ...
Toxicological analysis of the meal confirmed the presence of cucurbitacin. Dr. D.G. Hessayon (2009). The Vegetable and Herb ... However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilise edible ... can contain toxins called cucurbitacins. These are chemically classified as steroids; they defend the plants from predators, ...
Bean, M. F., Antoun, M., Abramson, D., Chang, C. J., McLaughlin, J. L., & Cassady, J. M. (1985). Cucurbitacin B and ... From Bean and cowrkers (1985), isolated cucurbitacin b, isocucurbitacin b (steroids) from roots Additionally, Satake et al. ( ...
However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilize edible ... Toxicological analysis of the meal confirmed the presence of cucurbitacin. Investigators warned that gardeners should not save ... can contain toxins called cucurbitacins. These are chemically classified as steroids; they defend the plants from predators, ... their own seeds, as reversion to forms containing more poisonous cucurbitacin might occur. Zucchini is very easy to cultivate ...
However, many species and also populations within species can be bitter due to cucurbitacins. Coccinia grandis is also well ...
Cucurbitacin glycosides are primarily responsible for the plants' bitterness and emetic effects. Variants of the plants' name, ...
Catherine N. Duckett
"Convergent Evolution of Cucurbitacin Pharmacophagy in Spatially Isolated Rootworm Taxa (Coleoptera: Chrysomelidae; Galerucinae ...
The fruit and foliage are toxic due to the presence of cucurbitacin. The plant is potentially toxic to horses, sheep, cattle ...
The plant contains dendrosycin, an iso-cucurbitacin with an unusual ring formation. Described in 1882 by Isaac Bayley Balfour, ...
... related to cucurbitacin, isolated by C. Ramalhete and others in 2009. Cucurbalsaminol A is an amorphous powder soluble in ...
The composition of the seeds per 100 g edible portion is: water 5.3 g, energy 2709 kJ (647 kcal), protein 30.7 g, fat 57.0 g, carbohydrate 2.3 g, crude fibre 1.3 g, Ca 100 mg, Mg 363 mg , Fe 4.0 mg, Zn 5.5 mg, niacin 2.2 mg. The composition of fresh fruits per 100 g edible portion is: water 84 g, energy 231 kJ (55 kcal), protein 1.4 g, fat 0.3 g, carbohydrate 11.7 g, fibre 1.0 g, Ca 21.4 mg, Mg 19.0 mg, P 22.4 mg, Fe 0.5 mg, Zn 0.6 mg, carotene 0.12 mg, thiamin 0.01 mg, riboflavin 0.02 mg, niacin 0.75 mg (Van den Eynden, V., Vernemmen, P. & Van Damme, P., 1992). The ripe fruits are aromatic and the pulp is rich in sugars. The fruit pulp and plant sap contain a non-volatile enzyme which curdles milk. A high percentage of the seed-oil is made up of polyunsaturated fatty acids, with a linoleic acid content of 53%. Green unripe fruits contain varying amounts of highly oxygenated tetracyclic triterpenoids, called cucurbitacins. Cucurbitacins B and D have been identified as the primary source of ...
Federal Register: September 1, 1999 (Volume 64, Number 169)] [Notices] [Page 47788-47791] >From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr01se99-95] ----------------------------------------------------------------------- ENVIRONMENTAL PROTECTION AGENCY [PF-889; FRL-6098-6] Notice of Filing a Pesticide Petition to Establish a Tolerance for Certain Pesticide Chemicals in or on Food AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. ----------------------------------------------------------------------- SUMMARY: This notice announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of certain pesticide chemicals in or on various food commodities. DATES: Comments, identified by docket control number PF-889, must be received on or before October 1, 1999. ADDRESSES: Comments may be submitted by mail, electronically, or in person. Please follow the detailed instructions for each method as provided in Unit I.C. ...
Repositório Científico da Atlântica: New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic...
The novel cucurbitacins, balsaminagenin A and B (1-2) and balsaminoside A (3) and the know cucurbitacin karavelagenin C (4), together with five new mono or diacylated derivatives (5-9) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells. Compounds 2-6 exhibited a strong activity compared with that of the positive control, verapamil. Structure-activity relationships are discussed. Moreover, in the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 2-5 synergistically enhanced the effect of the anticancer drug. Compounds 1-4 were isolated from the aerial parts of Momordica balsamina L. The structures of the compounds were established on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC and NOESY ...
Cucumbers are very hydrating (contain 96% water). Hydration is vital for healthy soft supple skin. Cucumbers have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammatory, and anti-cancer benefits. ...
i,Physocarpus malvaceus,/i, is a locally native woody shrub that grows on moist slopes and near streams in foothill to high elevation areas. The flowers have two (less commonly more) pistils as depicted above.While the large leaves are mallow-like, the plant is actually a member of the Rose... ...
General: A deciduous, many-branched shrub, 1-3 m tall. Young branches are smooth (glabrous) to slightly hair and somewhat angled; older branches have grayish-brown, papery bark that shreds off in long, thin layers.. Nomenclature: The name Physocarpus opulifolius (L.) Maxim. has been conserved over the earlier name, Physocarpus opulifolius Raf., which is now a rejected name (nom. rej.).. Leaves: Alternate, simple, palmately 3-lobed, and petiolate. Leaves have a broad, rounded to slightly cordate base, the three lobes are ovate to triangular, with blunt to acute tips, and crenate to coarsely toothed margins; young leaves develop lobes as they mature. Leaves are 3-7 cm long and almost as wide, dark green and paler beneath, and glabrous to slightly hairy; petioles are about 1-2 cm long.. Flowers: Showy, less than 1 cm across, with 5 white petals and a 5-lobed, green calyx; with numerous flowers arranged in rounded clusters (umbel-like corymbs). The flower stalks (pedicels) are minutely hairy and ...
Det er snålt hvordan smaken i hagen endrer seg med årene. Før likte jeg ikke gult i noen sammenhenger enten det var på blomster eller blader. Jeg er fortsatt ikke noen stor tilhenger av gule blomster, men har da noen sånn hist og pist. Men gult bladverk har jeg fått helt dilla på. I fjor kjøpte jeg flere gule thuja, og har en utrolig flott liten plante som jeg fikk som stikling for et par år siden. Det er Physocarpus opulifolius Darts Gold. Den står i skråningen og lyser som en liten sol for tiden. Jeg har bare et ankepunkt mot den, og det er at den ikke beholder den fine fargen hele sommeren. Sånn er det med noen gule hosta også, for de skifter til mere grønt utpå sommeren. Så derfor har jeg i år bestilt noen som etter sigende skal være like gule hele sesongen. Det gjenstår å se hvor gule de forblir ...
Angled luffa (luffa acutangula) Click on photo to enlarge There are two species of luffa (loofah) - angled luffa (luffa acutangula) and smooth skin luffa (luffa cylindrical). This article will focus on angled luffa. I will write about smooth skin luffa in another post. Angled luffa or loofah also known as ridged skin luffa, silk…
IDEALS @ Illinois: Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic...
Five species of Diabroticites with different host plant affinities produced an essentially identical array of metabolites when fed radio-labeled cucurbitacin B. All species excreted the bulk of the cucurbitacin (67.17-94.59% total dpm); permanently sequestered a small proportion of a cucurbitacin D conjugate in the hemolymph (0.98-2.76%); and apportioned the remainder between the gut, the body and the eggs (when present). Markedly different ratios between the excretory metabolites, i.e., polar vs. unmetabolized cucurbitacin, suggest that Diabrotica virgifera virgifera, a grass specialist, and Acalymma vittatum, a cucurbit specialist, have lower rates of metabolic alteration than D. undecimpunctata howardi and D. balteata which are polyphagous and D. cristata ...
The biosynthesis of cucurbitacin C has been described. Zhang et al. (2014) identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. These authors also discovered the transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. The Bi gene confers bitterness to the entire plant and is genetically associated with an operon-like gene cluster, similar to the gene cluster involved in thalianol biosynthesis in Arabidopsis. Fruit bitterness requires both Bi and the dominant Bt (Bitter fruit) gene. Nonbitterness of cultivated cucumber fruit is conferred by bt, an allele selected during domestication. Bi is a member of the oxidosqualene cyclase (OSC) gene family. Phylogenetic analysis showed that Bi is the ortholog of cucurbitadienol synthase gene CPQ in squash (Cucurbita pepo)  ...
The small GTPase Rac1 has been widely implicated in mammary tumorigenesis and metastasis. Previous studies established that stimulation of ErbB receptors in breast cancer cells activates Rac1 and enhances motility via the Rac-GEF P-Rex1. As the Jak2/Stat3 pathway has been shown to be functionally associated with ErbB receptors, we asked if this pathway could mediate P-Rex1/Rac1 activation in response to ErbB ligands. Here we found that the anticancer agent cucurbitacin I, a Jak2 inhibitor, reduced the activation of Rac1 and motility in response to the ErbB3 ligand heregulin in breast cancer cells. However, Rac1 activation was not affected by Jak2 or Stat3 RNAi, suggesting that the effect of cucurbitacin I occurs through a Jak2-independent mechanism. Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin. Subsequent analysis revealed that cucurbitacin I strongly activates RhoA and the Rho effector ROCK in breast cancer cells and induces the formation of stress fibers. ...
Dishrag gourd, smooth luffa, luff, lufa, belustra, nerua, calabaza de aristas, sponge luffa, kimput, bloostru, ghiya tori, nenwa, ta tsu kua, shui kwa, loofah, dishcloth gourd, vegetable sponge gourd, Pepinillo de San Gregorio, patola, patolang bilog, Loefahspons, Plantaardige spons, Schwammgurke, Hechima, Esponja vegetal. ...
Although different Zicam products contain different ingredients, some of the active ingredients in Zicam cold remedies are galphimia glauca, luffa operculata, sabadilla, zincum aceticum, and zincum...
Cucurbitacin B and Cucurbitacin C are the names of the compounds which cause bitterness in cucumbers. These compounds are found in all plant parts, but are concentrated in the stem end of the fruit. There is some in the blossom end, as well. Different varieties of cucumbers seem to contain more bitterness than others. You can cut off the ends to remove the bulk of the bitterness, but there will still be some under the skin of the cuke. Some people believe that if they peel a cucumber from the stem end to the blossom end, theyll remove more of the bitterness. There have been scientific studies, and the direction of peeling doesnt really make any difference in the amount of bitterness in a cucumber ...
Magnusiomyces capitatus ATCC ® 28576D-2™ Designation: Genomic DNA from Magnusiomyces capitatus strain IGC 3709 [ATCC ® 28576™] Application:
Grow your own Luffa sponge Luffa cylindrica or sponge gourd is a large annual vine that grows 30 or more in one season. It has its origin in Sou
This study was devoted to the development of pulp Luffa Cclindrica and its characterization paper (annual plant fiber of the family Cucurbitaceae). Baking at soda helps to achieve a high level of delignification (Kappa ≤ 10) and high yield (≈ 67%).The beatability stack Valley is comparable to refined wood fibers, the fibers develop a normally time with good hydrophilic properties without excessive morphological variations. The Comparing to the same level of physical properties of refining pulp Luffa cylindrica with different pulps annual plants (straw, bagasse or kenaf), obtained by different processes, shows good mechanical properties of the fibers, in addition its behavior would tend to approach more the hardwood pulps. The measured thermal conductivity on the handsheets Luffa Cylindrica was found equal to 0.112 W / m K, value being also in the rather broad range of the data of the literature on different types of pulp, between 0.1 and 0.2 W / m K.
kód: 0635 rod: Coreopsis druh: Coreopsis verticillata Moonbeam čeľaď: Asteraceae slov. názov: kráska praslenová
A. This is an excellent natural product and does not contain anti-histamine. A.Vogel Luffa Complex Drops 50ml. Buy it in Health Care and Health on Bubbles
Page contains details about hybrid polymeric micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
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Patola also known as Luffa acutangula or sponge gourd. This commodity is popularly known as vegetable and bath sponge. I am gathering health information about this vegetable. The following are the data that I have gathered so far: 1) Analyses of the unripe fruit show it is good source of calcium and iron and an…
Cavalier-Smith,T (1998): A revised six-kingdom system of life. ,Biological Reviews 73(3), 203-266. , ,Subphylum Polychaeta, Infraphylum NOV. Operculata (Spirorbis, Serpula), ,Infraphylum NOV. Pharyngata (Nereis, Arenicola, Sabella). We should feel honoured that the great Tom Cavalier-Smith, famous for his multifarious hypotheses about the evolution and classification of the Eukaryota, has deigned to cast his eye on our little clade (or grade). For Tom, paraphyly and polyphyly are not dirty words, they give one an opportunity to revise, and revise again. So look out for his new, improved, 7 Superduper-Kingdom system in your library sometime soon. ********************************* Greg Rouse School of Biological Sciences A08 University of Sydney N.S.W. 2006 Australia gregr at bio.usyd.edu.au Tel. (02) 9351 5571 Fax (02) 9351 4119 International: 61 2 replaces 02 -- ANNELIDA Discuss = annelida at net.bio.net = talk to all members Server = biosci-server at net.bio.net = un/subscribes Archives = ...
Hydrilla verticillata is one of the most serious and troublesome aquatic weeds in the worlds waterways. Its massive spread is largely due to human activities, such as boating and fishing and the aquarium trade. It is a severe problem in several areas in the U.S.; in Florida it has infested a large percentage of the states waters. Large subsurface masses of underwater branches form that impede navigation, interfere with hydroelectric plants, clog irrigation canals, affect water supplies, and block light, displacing native plants. This species produces four distinct vegetative disseminule types, undoubtedly one of the reasons for its prodigious spread. The only known seed production is in monoecious populations in North Carolina.. ...
The Metrosideros operculata Labill., Sert. Austro-Caled. (1824) 61, group is restricted to New Caledonia and has a wide altitudinal range, mostly in shrub associations, from near sea level to about 1500 metres ...
Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins | Protocol (Translated to Norwegian)
Biokjemiske og strukturelle analyser av glycosylated proteiner krever relativt store mengder homogen prøver. Her presenterer vi en...
Cucurbita legal definition of Cucurbita
Enhancement of callus induction and cucurbitacin content in Citrullus colocynthis L. (Schrad) using plant growth regulators ...https://legal-dictionary.thefreedictionary.com/Cucurbita
Cucurbitacin - Wikipedia
Cucurbitacin S. *Cucurbitacin S from Bryonia dioica :8485. Cucurbitacin T. *Cucurbitacin T, from the fruits of ... Cucurbitacin K. *Cucurbitacin K, stereoisomer of cucurbitacin J,:2 from Iberis amara :70 *Cucurbitacin K 2-O-β- ... Cucurbitacin O. *Cucurbitacin O from Brandegea bigelovii :73 *Cucurbitacin Q 2-O-glucoside, from Picrorhiza kurrooa [1 ... Cucurbitacin J. *Cucurbitacin J from Iberis amara :69 *Cucurbitacin J 2-O-β-glucopyranoside from Trichosanthes ...https://en.wikipedia.org/wiki/Cucurbitacin
Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. | Sigma-Aldrich
Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.. [Rachid Chawech, Raoudha Jarraya, Cynthia Girardi, Marieke ... glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. ...https://www.sigmaaldrich.com/catalog/papers/26437392
Cucurbitacin E - Wikipedia
Cucurbitacin E is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the ... Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J ... Cucurbitacin E inhibits the adhesion of cancer cells in type I collagen . Cucurbitacin-E protects hepatocytes from CCl4 (carbon ... Cucurbitacin E is an important inhibitor during the S to M phase in the cell mitosis. It causes a reduction of cell ...https://en.wikipedia.org/wiki/Cucurbitacin_E
Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer
Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ... Upon cucurbitacin B treatment, upregulation of DNMT1 and obvious heavy methylation in the promoters of c-Myc, cyclin D1, and ... Hence, cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ... Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the ...https://www.greenmedinfo.com/article/cucurbitacin-b-proved-be-potential-cancer-therapeutic-agent-part-inducing-hype
cucurbitacins Pesticide Petition Filing 8/99
Cucurbitacin I is the most toxic. The LD,INF,50,/INF, of cucurbitacin E-glycoside, one of the more effective insect feeding ... Most cucurbitacins are insoluble in water and transfer of these cucurbitacins to ground water is unlikely. The glycosylated ... The cucurbitacins occur in nature in mixtures. Cucurbitacin B [25-(acetyloxy)-2,16,20- trihydroxy-9-methyl-19-norlanosta- 5,23- ... Cucurbitacins from the buffalo gourd and zucchini squash are currently used in pesticide products. Cucurbitacins are oxygenated ...http://pmep.cce.cornell.edu/profiles/miscpesticides/alphaalkyl-metaldehyde/cucurbitacins/cucurbaticins_pet_899.html
Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons
... Anne-Marie Arel- ... Anne-Marie Arel-Dubeau, Fanny Longpré, Julie Bournival, et al., "Cucurbitacin E Has Neuroprotective Properties and Autophagic ...https://www.hindawi.com/journals/omcl/2014/425496/cta/
Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons
... Anne-Marie Arel- ... We evaluated the neuroprotective potential of cucurbitacin E (CuE), a tetracyclic triterpenoid phytosterol extracted from the ...https://www.hindawi.com/journals/omcl/2014/425496/abs/
cucurbitacin - oi
Cucurbitacins as Feeding and Oviposition Deterrents to Insects 496PAlterations of cellular proliferation, apoptosis and ... Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF-κB signaling ... Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in ... Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal ...http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095652176
Cucurbitacin E(P)- CAS Number 18444-66-1
Buy Cucurbitacin E(P) - CAS Number 18444-66-1 from LGC Standards. Please login or register to view prices, check availability ...https://www.lgcstandards.com/FR/en/Cucurbitacin-E-P-/p/CDX-00003910-010
Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability. | Sigma-Aldrich
Cucurbitacin B hydrate, ≥97% (HPLC) C32H46O8 · xH2O ... cucurbitacin B (Cuc B), using a galactosylated lipid, N- ... Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability.. [Wenyu Wang, Xiuli Zhao, ...https://www.sigmaaldrich.com/catalog/papers/20148709
CUCURBITACIN D with HPLC | 3877-86-9 | INDOFINE Chemical Company
INDOFINE Chemical Company supplies CUCURBITACIN D with HPLC for pharmaceutical, agricultural and life science industries. We ...https://indofinechemical.com/details.aspx?Sku=020023S
CUCURBITACIN I with HPLC | 2222-07-3 | INDOFINE Chemical Company
INDOFINE Chemical Company supplies CUCURBITACIN I with HPLC for pharmaceutical, agricultural and life science industries. We ...https://indofinechemical.com/details.aspx?Sku=020021S
Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha | BMC Genomics | Full Text
This study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any ... In this study, we present a draft genome and a putative pathway for cucurbitacin E and I, compounds with known medicinal value ... The expression changes for cucurbitacin E and I are shown to be consistent with known responses of A. agallocha to biotic ... stress and a set of homologous genes in Arabidopsis thaliana related to cucurbitacin bio-synthesis is presented and validated ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-578
Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical...
Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer ( ... Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical ...https://www.ncbi.nlm.nih.gov/pubmed/23340170?dopt=Abstract
Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been - Aurora Kinases as Druggable...
Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been. February 24, 2019. GAT ... We discovered that cucurbitacin B induced autophagy in Jurkat cells, which appeared to be a pro-survival response . Also, ... Cucurbitacins, the organic triterpenoids possessing many biological actions, have already been reported to suppress the mTORC1/ ... Intro Cucurbitacins participate in a large category of triterpenoids within Cucurbitaceae plants, and still have many ...http://www.exposed-skin-care.net/2019/02/24/cucurbitacins-the-organic-triterpenoids-possessing-many-biological-actions-have-already-been/
The Anti-Melanoma Efficiency of the Intratumoral Injection of Cucurbitacin-Loaded Sustained Release Carriers: In Situ-Forming...
Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma ... anti-melanoma efficiency cucurbitacin drug release in situ-forming implants (ISFIs) intratumoral injection ... The Anti-Melanoma Efficiency of the Intratumoral Injection of Cucurbitacin-Loaded Sustained Release Carriers: In Situ-Forming ... Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma ...https://rd.springer.com/article/10.1208/s12249-015-0292-2
Cucurbitacin E, An Experimental Lead Triterpenoid With Anticancer, Immunomodulatory and Novel Effects Against Degenerative...
During the past sixty years, several cucurbitacins hav … ... Cucurbitacins as Anticancer Agents: A Patent Review. Hussain H ... Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Ito A, Chai HB, Lee D, Kardono LB, Riswan S, ... Cucurbitacins are triterpenoid compounds originally identify as the bitter components of the Cucurbit family that demonstrated ... Specifically, Cucurbitacin E (CuE), an oxygenated tetracyclic triterpenoid, has been investigated in a wider array of ...https://pubmed.ncbi.nlm.nih.gov/25915611/
Comparison between the effects of potassium phosphite and chitosan on changes in the concentration of Cucurbitacin E and on...
The aim of this study was to investigate the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) ... Cucurbitacins are mostly found in the members of the family Cucurbitaceae and are responsible for the bitter taste of cucumber ... Seeds exhibit very low concentration of cucurbitacins . The diversity of cucurbitacins lies in side chain derivatives that ... Cucumis sativus belongs to Cucurbitaceae family and is known to be rich in cucurbitacins. Cucurbitacins have become interesting ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1808-y
IDEALS @ Illinois: Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic...
beetles fed on squash fruit containing cucurbitacins were rejected. Moreover, even when adults did not feed on cucurbitacins, ... fruit devoid of cucurbitacins). The longevity of female A. vittatum, however, was unaffected by the presence or absence of ... Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the ... Disposition of Cucurbitacin as a Factor in Host Plant Selection by Diabroticite Beetles and Electrophoretic Analysis of the ...https://www.ideals.illinois.edu/handle/2142/71776
Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin. Subsequent analysis revealed that cucurbitacin I ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ... Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1 ...http://molpharm.aspetjournals.org/content/early/2013/03/11/mol.112.084293
Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug...
Synergistic effect of cucurbitacin B in combination with curcuminviaenhancing apoptosis induction and reversing multidrug ... Cucurbitacin B is a plant-derived tetracyclic triterpenoid, which has been used for a variety of cancers, especially human ... In conclusion, cucurbitacin B in the combination with curcumin could serve as a novel, promising approach for human hepatoma. ... In the present study, the synergistic effect of cucurbitacin B and curcumin was studied on BEL7402/5-Fu cells in vitro and ...https://insights.ovid.com/eujoph/201512051/00003656-201512051-00004
Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic...
Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer ... Cucurbitacin-I (JSI-124) can be found in a variety of plants that have been used for centuries as folk medicines in Asia [1-3 ... Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer ... Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-268
Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma...
Co-administration of cucurbitacin I (250 nM) produces a significant blockade of this effect. Cucurbitacin I alone also produced ... Cucurbitacin I had no effect on basal phosphorylation of STAT3 but reduced phorphorylated p44/42 MAPK in 2 grade II meningioma ... Recently, cucurbitacin I (JSI-124), a naturally occurring tetracyclic triterpenoid compound used as folk medicines has been ... The effects of cucurbitacin I on cerebrospinal fluid stimulation of meningioma cell DNA synthesis phosphorylation/activation of ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-13-303
Insecticidal Effect of Cucurbitacin E Glycoside Isolated from Citrullus colocynthis Against Aphis craccivora
... H.M., Torkey,; H. ... Insecticidal Effect of Cucurbitacin E Glycoside Isolated from Citrullus colocynthis Against Aphis craccivora. Login ...http://dspace.must.edu.eg/handle/123456789/215
Tetracyclic triterpenoidSTAT3InhibitoryInhibitorCucumisApoptosisUpregulationAngiogenesisAntiproliferativeInduceVivoActinCytotoxicityActivatesCucumberHepaticInductionDerivativesIncluding toxicitySpeciesReadilyCucurbitaneAntioxidantEffectConcentrationSquashDiseasesConsistentStudyGrowthSignificantlyActivitiesHumanAffect
- We evaluated the neuroprotective potential of cucurbitacin E (CuE), a tetracyclic triterpenoid phytosterol extracted from the Ecballium elaterium (Cucurbitaceae), using a known cellular model of PD, NGF-differentiated PC12. (hindawi.com)
- Specifically, Cucurbitacin E (CuE), an oxygenated tetracyclic triterpenoid, has been investigated in a wider array of bioactivities, mainly immunomodulatory. (nih.gov)
- Cucurbitacin B is a plant-derived tetracyclic triterpenoid, which has been used for a variety of cancers, especially human hepatoma. (ovid.com)
- Recently, cucurbitacin I (JSI-124), a naturally occurring tetracyclic triterpenoid compound used as folk medicines has been found to have cytoxic and anti-proliferative properties in several malignancies thru inhibition of activator of transcription (STAT3) activation. (biomedcentral.com)
- Some studies indicate the inhibition of Jak/sign transducer and activator of transcription 3 (STAT3) signaling becoming the ISG15 mechanism in charge of inhibitory ramifications of cucurbitacins on tumor cells , while some support the idea that it's the fast disruption from the actin cytoskeleton by cucurbitacins becoming in charge of their anticancer actions [3, (exposed-skin-care.net)
- Apart from their actions within the actin cytoskeleton and Jak/STAT3 signaling, cucurbitacins possess recently been proven to inhibit the mTORC1 activity in tumor cells . (exposed-skin-care.net)
- However, Rac1 activation was not affected by Jak2 or Stat3 RNAi, suggesting that the effect of cucurbitacin I occurs through a Jak2-independent mechanism. (aspetjournals.org)
- Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia. (biomedcentral.com)
- The effects of cucurbitacin I on cerebrospinal fluid stimulation of meningioma cell DNA synthesis phosphorylation/activation of JAK1, STAT3, pMEK1/2, p44/42MAPK, Akt, mTOR, Rb and caspase 3 activation were analyzed in human leptomeningeal and meningioma cells. (biomedcentral.com)
- Cucurbitacin I had no effect on basal STAT3 phosphorylation but co-administration with cerebrospinal fluid blocked cerebrospinal fluid stimulation of STAT3 phosphorylation in each. (biomedcentral.com)
- In the grade I meningiomas, cerebrospinal fluid stimulated phosphorylation of STAT3 and decreased MEK1/2 and cucurbitacin I had no effect on basal STAT3, p44/42MAPK, Akt, JAK1, mTOR, or Rb phosphorylation. (biomedcentral.com)
- Cucurbitacin I had no effect on basal phosphorylation of STAT3 but reduced phorphorylated p44/42 MAPK in 2 grade II meningioma cells lines. (biomedcentral.com)
- Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. (adooq.com)
- Growth inhibitory effect of cucurbitacin B on breast cancer cells was assessed by MTT assay and colony formation assay. (greenmedinfo.com)
- Interestingly, disruption of the RhoA-ROCK pathway prevented the inhibitory effect of cucurbitacin I on Rac1 activation by heregulin. (aspetjournals.org)
- The ROS scavenger N-Acetyl L-cysteine (NAC) and the mitochondrial anti-oxidant Mito-TEMPO rescued the inhibitory effect of cucurbitacin I on Rac1 activation. (aspetjournals.org)
- Moreover, they established that the inhibitory effect of cucurbitacin I on Rac1 activity involves the alteration of the balance between Rho and Rac. (aspetjournals.org)
- Cucurbitacin E is an important inhibitor during the S to M phase in the cell mitosis. (wikipedia.org)
- Here we found that the anticancer agent cucurbitacin I, a Jak2 inhibitor, reduced the activation of Rac1 and motility in response to the ErbB3 ligand heregulin in breast cancer cells. (aspetjournals.org)
- Phylogenetic analysis showed that Bi is the ortholog of cucurbitadienol synthase gene CPQ in squash (Cucurbita pepo) The cucurbitacins include: Cucurbitacin A found in some species of Cucumis Pentanorcucurbitacin A, or 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one C 25H 40O 2, white powder Cucurbitacin B from Hemsleya endecaphylla (62 mg/72 g) and other plants (e.g. (wikipedia.org)
- Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells. (nih.gov)
- The aim of this study was to investigate the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) concentration in different tissues of Cucumis sativus . (biomedcentral.com)
- Cucumis sativus belongs to Cucurbitaceae family and is known to be rich in cucurbitacins. (biomedcentral.com)
- Hepatoprotecive effect Insecticide effect Cucurbitacin E anti-inflammatory activities are proved in vivo and in vitro. (wikipedia.org)
- In the present study, the synergistic effect of cucurbitacin B and curcumin was studied on BEL7402/5-Fu cells in vitro and BEL7402 tumor-bearing mice in vivo. (ovid.com)
- Additional studies are warranted to evaluate the effects of cucurbitacin I on meningiomas in vivo. (biomedcentral.com)
- Cucurbitacins can disrupt the actin cytoskeleton quickly, resulting in a designated cell deformation, followed from the activation of many stress-sensing signaling pathways [3, (exposed-skin-care.net)
- Latest function indicated that cucurbitacins may focus on cofilin [6, a crucial regulator of actin dynamics, therefore harming the actin cytoskeleton. (exposed-skin-care.net)
- Oddly enough, cofilin-actin rods had been shaped in cells treated with cucurbitacin B and such pole formation depends on the over-activation of cofilin . (exposed-skin-care.net)
- The purpose of this work was to ă compare the cytotoxicity of three cucurbitacins I, D, E on the ă chondrosarcoma SW 1353 cancer cell line and to investigate their ă biotransformation in man. (univ-lorraine.fr)
- Cucurbitacins I and D showed a very strong ă cytotoxicity, which was higher than that of cytochalasin D, used as a ă drug reference. (univ-lorraine.fr)
- This study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any species of Aquilaria. (biomedcentral.com)
- During the past sixty years, several cucurbitacins have been isolated from a number of cucurbitaceous species, amongst others. (nih.gov)
- Males of four Diabroticite species consumed an average of 27.4% more artificial diet after the incorporation of 0.5 mg cucurbitacin D per g fwt diet whereas female consumption increased only 5.0% on the average. (illinois.edu)
- Four species of Diabroticites were shown for the first time to sequester cucurbitacins. (illinois.edu)
- Lastly, we found that RhoA activation by cucurbitacin I is mediated by reactive oxygen species (ROS). (aspetjournals.org)
- Cucurbitacins are chemically classified as steroids , formally derived from cucurbitane , a triterpene hydrocarbon -specifically, from the unsaturated variant cucurbita-5-ene , or 19-(10→9β)- abeo -10α-lanost-5-ene. (wikipedia.org)
- It has also been proved that Cucurbitacin E is an activator of T-lymphocytes and its effect increases when it is associated with PHA molecule. (wikipedia.org)
- Co-administration of cucurbitacin I (250 nM) produces a significant blockade of this effect. (biomedcentral.com)
- Co-administration of cucurbitacin I (250 nM) blocked this effect. (biomedcentral.com)
- Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J, K and L. It is being investigated as a treatment for many diseases. (wikipedia.org)
- Cucurbitacin E, An Experimental Lead Triterpenoid With Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. (nih.gov)
- The expression changes for cucurbitacin E and I are shown to be consistent with known responses of A. agallocha to biotic stress and a set of homologous genes in Arabidopsis thaliana related to cucurbitacin bio-synthesis is presented and validated through qRT-PCR. (biomedcentral.com)
- Moreover, even when adults did not feed on cucurbitacins, 21-24% of A. vittatum were rejected by the mantids which is consistent with larval sequestration of cucurbitacins. (illinois.edu)
- In this study, we explore the influence of cucurbitacin B fromon the methylation status at the promoter of oncogenes c-Myc, cyclin D1, and survivin in breast cancer cell lines. (greenmedinfo.com)
- This study intended to prepare liver-targeting solid lipid nanoparticles (SLNs) with a hepatoprotective drug, cucurbitacin B (Cuc B), using a galactosylated lipid, N-hexadecyl lactobionamide (N-HLBA). (sigmaaldrich.com)