Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.
A plant genus of the family CUCURBITACEAE known for the fruit which is the source of the luffa sponge and the seeds which contain luffin.
The gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.

Two new cucurbitacin glucosides, opercurins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata). (1/12)

The structures of two new cucurbitacin glucosides designated opercurins A (1) and B (2), isolated from the fruit of Luffa operculata, have been confirmed by extensive spectroscopic investigation.  (+info)

Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. (2/12)

The aim of this study was to investigate the effects of cucurbitacin R on an experimental model of adjuvant-induced arthritis in rats. The treatment of arthritic rats with cucurbitacin R (1 mg/kg p.o. daily) modified the evolution of the clinical symptoms, whereas the histopathology of paws demonstrated a reduction in the signs of arthritis. Compared with the control group, radiography of the tibiotarsal joints of cucurbitacin R-treated rats showed a decrease in joint damage and soft tissue swelling of the footpad. The in vivo study of the expression of proinflammatory enzymes (nitric-oxide synthase-2 and cyclooxygenase-2) with the aid of the Western blot technique, and that of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E(2) by means of enzyme-linked immunosorbent assays demonstrated a clear decrease in both the enzymes and the mediators in paw homogenates. The analysis for prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes, indicated a reduction of all mediators. The expression of cyclooxygenase-2 was not modified in RAW 264.7 macrophages, whereas the expression of nitric-oxide synthase-2 was clearly diminished. Moreover, cucurbitacin R was found to inhibit signal transducer and activator of transcription 3 activation in the lymphocytes of both healthy and arthritic men. These experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents.  (+info)

Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. (3/12)

Poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and newly developed poly(ethylene oxide)-block-poly(alpha-benzyl carboxylate epsilon-caprolactone) (PEO-b-PBCL) micelles were evaluated for the solubilization and delivery of cucurbitacin I and B, poorly water soluble inhibitors of signal transducer and activator of transcription 3 (STAT3). Encapsulation of cucurbitacins in PEO-b-PCL and PEO-b-PBCL by co-solvent evaporation technique resulted in polymeric micelles <90 nm in diameter. The aqueous solubility of both derivatives increased from less than 0.05 mg/mL in the absence of the copolymer to around 0.30-0.44 and 0.65-0.68 mg/mL in the presence of 5000-5000 and 5000-24,000 PEO-b-PCL micelles, respectively. Maximum cucurbitacin solubilization was achieved with PEO-b-PBCL micelles for both derivatives. PEO-b-PCL micelles having longer PCL block were found to be more efficient in sustaining the rate of release for cucurbitacins. The anti-cancer and STAT3 inhibitory activity of polymeric micellar cucurbitacins were comparable with free drugs in B16.F10 melanoma cell line in vitro. Intratumoral injection of 1 mg/kg/day cucurbitacin I resulted in the regression of established B16.F10 mouse melanoma tumors in vivo. In comparison to free cucurbitacin I, PEO-b-PBCL micellar cucurbitacin I was found to provide comparable anti-cancer effects against B16.F10 tumors and limit drug levels in animal serum while maintaining high drug levels in tumor following intratumoral administration. The results indicate the potential of polymeric micelles as suitable vehicles for the delivery of cucurbitacin- I and B.  (+info)

Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity. (4/12)

Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).  (+info)

Differential regulation of STAT family members by glycogen synthase kinase-3. (5/12)

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Actin-aggregating cucurbitacins from Physocarpus capitatus. (6/12)

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Cucurbitacin: ancient compound shedding new light on cancer treatment. (7/12)

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Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. (8/12)

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54 Cucurbitacin H, stereoisomer of cucurbitacin G, from roots of Wilbrandia ebracteata: 53 Cucurbitacin I (elatericin B) from ... 71 Cucurbitacin K, stereoisomer of cucurbitacin J,: 2 from Iberis amara: 70 Cucurbitacin K 2-O-β-glucopyranoside from ... actually Cucurbitacin F 25-acetate Cucurbitacin R is actually 23,24-dihydrocucurbitacin D. Cucurbitacin S from Bryonia dioica: ... Cucurbitacins B and I, and derivatives of cucurbitacins B, D and E, can be extracted with methanol from dried tubers of ...
... is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the ... Specific changes on this molecule under certain conditions can generate other types of cucurbitacins such as cucurbitacin I, J ... cucurbitacin E inhibits the adhesion of cancer cells in type I collagen. In vitro, cucurbitacin E protects hepatocytes from ... Cucurbitacin E is an inhibitor during the S to M phase in the cell mitosis. It causes a reduction of cell multiplication.[ ...
... is a plant steroid with anticancer activity. Cucurbitacin D induces growth inhibition, cell cycle arrest, and ...
In enzymology, a cucurbitacin Delta23-reductase (EC 1.3.1.5) is an enzyme that catalyzes the chemical reaction 23,24- ... This enzyme is also called NAD(P)H: cucurbitacin B Delta23-oxidoreductase. It employs one cofactor, manganese. Schabort JC, ... Schabort JC, Potgieter DJ, de Villiers V (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. I. Assay methods, ... Potgieter DJ (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. II Cofactor requirements, enzyme kinetics, ...
Bhandari, Pamita; Kumar, Neeraj; Singh, Bikram; Kaul, Vijay K. (2007). "Cucurbitacins from Bacopa monnieri". Phytochemistry. 68 ... cucurbitacin and plantainoside B. Lansdown, R.V.; Knees, S.G.; Patzelt, A. (2013). "Bacopa monnieri". IUCN Red List of ...
Important sub-classes include sterols and cucurbitacins. Triterpenoid saponins are triterpenes which belong to the saponin ...
Cucurbitacin I (JSI-124). CHZ868 - a type II JAK2 inhibitor for use in myeloproliferative disorders and chronic myelomonocytic ... Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (March 2003). "Discovery of JSI-124 (cucurbitacin I), a selective ...
The blades of the plant contain cucurbitacins, which are poisonous to some animals, and some of them are among the bitterest ... Kupchan, S.Morris; Meshulam, Haim; Sneden, Albert T. (1978). "New cucurbitacins from Phormium tenax and Marah oreganus". ...
Cucurbitacins A-L, O-T: 3-8 Datiscosides, from Datisca glomerata: 16-19 Endecaphyllacins A and B, from roots of Hemsleya ... Anmol Publications, India Chen, J. C.; Chiu, M. H.; Nie, R. L.; Cordell, G. A.; Qiu, S. X. (2005). "Cucurbitacins and ...
... there are occasional reports of cucurbitacin causing illness in humans. Cucurbitacin is also used as a lure in insect traps. ... Cucurbitacin is a plant steroid present in wild Cucurbita and in each member of the family Cucurbitaceae. Poisonous to mammals ... Ingesting too much cucurbitacin can cause stomach cramps, diarrhea and even collapse. This bitterness is especially prevalent ... Chen, Jian Chao; Chiu, Ming Hua; Nie, Rui Lin; Cordell, Geoffrey A.; Qui, Samuel X. (2005). "Cucurbitacins and Cucurbitane ...
Some cucurbitacins can be made anti-rheumatic agent. "Cucurbitaceae Cayaponia tayuya". International Plant Names Index. ... Studies in rodent models have shown that several cucurbitacins isolated from tayuya may have anti-inflammatory properties and ... "Cucurbitacin IIb Exhibits Anti-Inflammatory Activity through Modulating Multiple Cellular Behaviors of Mouse Lymphocytes". PLOS ... "Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots". Planta Medica. 70 (5): 414-20. doi: ...
The slightly bitter taste of cucumber rind results from cucurbitacins. In general cultivation, cucumbers are classified into ...
... s are cucurbitacins, formally derived from the triterpene hydrocarbon cucurbitane. They include: Kuguacin A Kuguacin B ...
... but also cucurbitacins, which are better known as chemical defenses in the Cucurbitaceae plant family. Cucurbitacins from ... Nielsen, Jens Kvist; Larsen, Lone Melchior; Søorensen, Hilmer (1977-01-01). "Cucurbitacin E and I in Iberis amara: Feeding ... Sachdev-Gupta, Kusum; Radke, Celia D.; Renwick, J. Alan A. (1993-08-12). "Antifeedant activity of cucurbitacins from Iberis ... Cucurbitacins from Iberis umbellata (globe candytuft) are ecdysteroid antagonists, acting on the ecdysteroid receptor of ...
... related to cucurbitacin. Karavilagenin E is soluble in methanol and ethyl acetate but insoluble in n-hexane. Balsaminapentaol ...
Toxicological analysis of the meal confirmed the presence of cucurbitacin. "The Marrow Song", also known as "Oh! What a Beauty ... However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilise edible ... can contain toxins called cucurbitacins. These are chemically classified as steroids; they defend the plants from predators, ...
Cucurbitacin b and isocucurbitacin b have been isolated from the roots. Additionally, Satake et al. (1999) isolated rosmarinic ... Bean, M. F., Antoun, M., Abramson, D., Chang, C. J., McLaughlin, J. L., & Cassady, J. M. (1985). Cucurbitacin B and ...
The leaves and fruit contain high concentrations of tetracyclic triterpenoid compounds known as cucurbitacins. They impart a ...
However, many species and also populations within species can be bitter due to cucurbitacins. Coccinia grandis is also well ...
However, ornamental pumpkins can have high levels of cucurbitacins, and such ornamental plants can cross-fertilize edible ... Zucchini occasionally contain toxic cucurbitacins, making them extremely bitter, and causing severe gastero-enteric upsets. ... can contain toxins called cucurbitacins. These are steroids which defend the plants from predators, and have a bitter taste to ... as reversion to forms containing more poisonous cucurbitacin might occur. Zucchini can also be responsible for allergy caused ...
Cucurbitacin glycosides are primarily responsible for the plants' bitterness and emetic effects. Variants of the plants' name, ...
"Convergent Evolution of Cucurbitacin Pharmacophagy in Spatially Isolated Rootworm Taxa (Coleoptera: Chrysomelidae; Galerucinae ...
The fruit and foliage are toxic due to the presence of cucurbitacin. The plant is toxic to humans as well as to horses, sheep, ...
The plant contains dendrosycin, an iso-cucurbitacin with an unusual ring formation. Described in 1882 by Isaac Bayley Balfour, ...
There was a major negative correlation between spider mite survival and cucurbitacin C amount. Shang Y, Ma Y, Zhou Y, et al. ( ... Although it is not clear what receptor activates the biosynthesis of cucurbitacin C, hydrogen sulfide (H2S) acts as a signaling ... conducted an experiment in 2003 testing the role of cucurbitacin C in spider mite resistance to cucumbers. There were four ... This significantly increases the amount of cucurbitacin C in the leaves, cotyledons, pedicel, carpopodium, and fruit. He et al ...
Additionally, other wild species have bitter fruit containing cucurbitacin.C. colocynthis (L.) Schrad. ex Eckl. & Zeyh., C. ...
Cucurbita fruits contain cucurbitacins, bitter compounds that are toxic to small herbivores but can be tolerated by megafauna; ...
Cucurbitacins and Cardenolides". Entomologia Experimentalis et Applicata. 24 (1): 41-54. doi:10.1111/j.1570-7458.1978.tb02755.x ...
Cucurbitacin Cucurbitin Egusi List of edible seeds List of squash and pumpkin dishes Song, Y.; Li, J.; Hu, X.; Ni, Y.; Li, Q. ( ...
Elaterium is the cucurbitacin extract used in ancient history as a purgative in folk medicine. Extracted from the juice of the ...
Pharmacognosy Research (Pharmacogn Res.). [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products.. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions ...
Cucurbitacin B Sterols [ST01] Cholesterol and derivatives [ST0101] 558.32 C32H46O8 LMST01010517 Cucurbitacin C7 25-acetyloxy- ...
Fresh fruit may be eaten, but contains cucurbitacins. In immature fruit, high enough amounts can burn the mouth. Ripe fruit ...
They also contain phytonutrients called cucurbitacins, which also have anti-cancer properties. According to the George Mateljan ... required for cancer cell development and survival can be blocked by activity of cucurbitacins." ...
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling ...
HN - 2008(1974) MH - Cucurbitacins UI - D054728 MN - D02.455.849.919.138 MS - Triterpenes that derive from LANOSTEROL by a ... HN - 2008 (1975); use CUCURBITACINS (NM) 1975-1980 MH - Pentacyclic Triterpenes UI - D053978 MN - D02.455.849.919.530 MS - Five ...
... cucurbitacin and valuable vitamins and minerals that are important to a healthy life and well-being. ... seeds as a treatment for intestinal parasites in the years 1863-1936 because they contain an amino acid called cucurbitacin, ...
Cucurbitacins B & E. Progranulin - Bulk Available. Recombinant human, mouse or rat Progranulin. ...
Mengandung cucurbitacin yang berfungsi menginduksi pelepasan insulin alami dalam tubuh untuk mengontrol gula darah. ...
Cucurbitacins - Preferred Concept UI. M0050173. Scope note. Triterpenes that derive from LANOSTEROL by a shift of the C19 ...
Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR - MAPK pathway. Mahnashi, Mater; Elgazwi, ...
Jia Q, Cheng W, Yue Y, Hu Y, Zhang J, Pan X, Xu Z and Zhang P: Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine ...
Chiefly momordicin I & momordicin II, cucurbitacin B. *Glycosides (momordin, charantin, charantosides, goyaglycosides) ...
Tehila, T. S., Bergman, M., and Grossman, S. (2007). "Cucurbitacin glucosides: Antioxidant and free-radical scavenging ...
Stuppner H, Wagner HNew cucurbitacin glycosides from Picrorhiza kurrooaPlanta Med. .. (. 1989 Dec. ). ...
Pumpkin seeds consist of cucurbitacin, a unique amino that helps your hair grow. Apart from this, they also contain vitamin C ... Pumpkin seeds consist of cucurbitacin, a unique amino that helps your hair grow. Apart from this, they also contain vitamin C ...
Cucumbers contain a compound called cucurbitacin, which can be toxic to some dogs. While the risk of cucurbitacin poisoning is ... Cucumbers contain a compound called cucurbitacin, which can cause gastrointestinal upset and discomfort in dogs. ...
According to one study, Cucurbitacin in watermelon has antitumor, anti-inflammatory, and hepatoprotective properties. ...
A new cucurbitacin glycoside, named hemsamabilinin B (2), was isolat-ed from Hemsleya amabilis Diels. 2 was hydrolyzed by ...
Pumpkin seeds are an extremely effective deworming agent because they contain an amino acid called cucurbitacin. This paralyzes ...
Cucumbers also contain a compound called Cucurbitacin C, which is believed to be beneficial to health. ...
The Toxicology Question of the Week is a venue that addresses interesting questions that have been asked of the Poison Center or are topics of relevance. The TPC toxicologists and other collaborators will contribute to the Question of the Week. The Question of the Week is overseen by Dr. Donna Seger, Professor Emeritus and the former Executive Director of the Tennessee Poison Center, who developed this resource in 2001. If you wish to be added to the distribution list, please email Ashley Nicholson at [email protected].. ...
Søren Bak: hairy roots in Cucumis sativa as a platform to the cucurbitacin production and optimization. ...
Pumpkin seeds are especially rich in numerous nutrients and one of the most important ones is cucurbitacin. It helps in the ...
Watermelon for the wellness win! Watermelon juice contains cucurbitacin E, a plant compound known for its anti-oxidant and anti ...
... iridioids and cucurbitacins (which are extremely bitter). In traditional Chinese medicine, picrorhiza has been used to treat ...
  • They also contain phytonutrients called cucurbitacins, which also have anti-cancer properties. (motherearthstorehouse.com)
  • The phytonutrients called cucurbitacins contained in cucumber has anti-cancer properties. (50amazingmoms.com)
  • Cucumbers are low in vitamins and minerals, but they do contain cucurbitacin E, w hich may be beneficial to health. (kenningscirclek.com)
  • Cucumbers contain a compound called cucurbitacin, which can be toxic to some dogs. (dogclassonline.com)
  • While the risk of cucurbitacin poisoning is low, it's important to be aware of the potential dangers, and it's best to avoid feeding your pup cucumbers with this compound. (dogclassonline.com)
  • 27. Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. (nih.gov)
  • 37. Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp. (nih.gov)
  • As evidenced by literature, pumpkin seeds are densely packed with nutrients and phytochemicals, such as dietary fiber, amino acids, phytosterols, unsaturated fatty acids, flavonoids, proteins, phenolic compounds and their derivatives, cucurbitacin and valuable vitamins and minerals that are important to a healthy life and well-being. (naturalnews.com)
  • 23. Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides. (nih.gov)
  • 32. Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity. (nih.gov)
  • 35. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. (nih.gov)
  • According to the George Mateljan Foundation: "Scientists have already determined that several different signaling pathways (for example, the JAK-STAT and MAPK pathways) required for cancer cell development and survival can be blocked by activity of cucurbitacins. (motherearthstorehouse.com)
  • 29. Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. (nih.gov)
  • 39. Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus. (nih.gov)
  • Recent research has shown that cucurbitacins can decapitate or inhibit the proliferation of cancer cells. (phcogres.com)
  • Cucurbitacin, a prominent class of triterpenoids found in L. echinata, has been proven effective in numerous reports. (phcogres.com)
  • 36. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. (nih.gov)
  • Cucurbitacins and withanolides can be successfully developed in combination with known TRAIL agonist have the potential of new cancer combination therapies without major toxicities. (nih.gov)
  • 40. Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. (nih.gov)