Cryptosporidiidae: A family of parasitic organisms in the order EIMERIIDA. CRYPTOSPORIDIUM is the most important genus.Coccidia: A subclass of protozoans commonly parasitic in the epithelial cells of the intestinal tract but also found in the liver and other organs. Its organisms are found in both vertebrates and higher invertebrates and comprise two orders: EIMERIIDA and EUCOCCIDIIDA.Cryptosporidium: A genus of coccidian parasites of the family CRYPTOSPORIDIIDAE, found in the intestinal epithelium of many vertebrates including humans.Flatfishes: Common name for the order Pleuronectiformes. A very distinctive group in that during development they become asymmetrical, i.e., one eye migrates to lie adjacent to the other. They swim on the eyeless side. FLOUNDER, sole, and turbot, along with several others, are included in this order.Cryptosporidiosis: Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.Oocysts: Zygote-containing cysts of sporozoan protozoa. Further development in an oocyst produces small individual infective organisms called SPOROZOITES. Then, depending on the genus, the entire oocyst is called a sporocyst or the oocyst contains multiple sporocysts encapsulating the sporozoites.Cryptosporidium parvum: A species of parasitic protozoa that infects humans and most domestic mammals. Its oocysts measure five microns in diameter. These organisms exhibit alternating cycles of sexual and asexual reproduction.Ciliophora Infections: Infections with protozoa of the phylum CILIOPHORA.Eimeria: A genus of protozoan parasites of the subclass COCCIDIA. Various species are parasitic in the epithelial cells of the liver and intestines of man and other animals.Giardia: A genus of flagellate intestinal EUKARYOTES parasitic in various vertebrates, including humans. Characteristics include the presence of four pairs of flagella arising from a complicated system of axonemes and cysts that are ellipsoidal to ovoidal in shape.Giardiasis: An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA LAMBLIA. It is spread via contaminated food and water and by direct person-to-person contact.Giardia lamblia: A species of parasitic EUKARYOTES that attaches itself to the intestinal mucosa and feeds on mucous secretions. The organism is roughly pear-shaped and motility is somewhat erratic, with a slow oscillation about the long axis.Disease Reservoirs: Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Zoonoses: Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Animals, ZooParasitology: The study of parasites and PARASITIC DISEASES.Parasitic Diseases: Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.Denture, Partial, Temporary: A partial denture intended for short-term use in a temporary or emergency situation.Compact Disks: Computer disks storing data with a maximum reduction of space and bandwidth. The compact size reduces cost of transmission and storage.Parasitic Diseases, Animal: Infections or infestations with parasitic organisms. The infestation may be experimental or veterinary.Trematoda: Class of parasitic flukes consisting of three subclasses, Monogenea, Aspidogastrea, and Digenea. The digenetic trematodes are the only ones found in man. They are endoparasites and require two hosts to complete their life cycle.Isochores: Large regions of the GENOME that contain local similarities in BASE COMPOSITION.Potassium Dichromate: Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.Bursa of Fabricius: An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.Base Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.China: A country spanning from central Asia to the Pacific Ocean.Premarital Examinations: Medical tests taken by couples planning to be married in order to determine presence of genetic and contagious diseases.Sarcocystidae: A family of parasitic organisms in the order EIMERIIDAE. They form tissue-cysts in their intermediate hosts, ultimately leading to pathogenesis in the final hosts that includes various mammals (including humans) and birds. The most important genera include NEOSPORA; SARCOCYSTIS; and TOXOPLASMA.Polymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.United States Health Resources and Services Administration: A component of the PUBLIC HEALTH SERVICE that provides leadership related to the delivery of health services and the requirements for and distribution of health resources, including manpower training.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Centers for Medicare and Medicaid Services (U.S.): A component of the Department of Health and Human Services to oversee and direct the Medicare and Medicaid programs and related Federal medical care quality control staffs. Name was changed effective June 14, 2001.Medicaid: Federal program, created by Public Law 89-97, Title XIX, a 1965 amendment to the Social Security Act, administered by the states, that provides health care benefits to indigent and medically indigent persons.Medicare: Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)United StatesShock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.Western Australia: A state in western Australia. Its capital is Perth. It was first visited by the Dutch in 1616 but the English took possession in 1791 and permanent colonization began in 1829. It was a penal settlement 1850-1888, became part of the colonial government in 1886, and was granted self government in 1890. (From Webster's New Geographical Dictionary, 1988, p1329)Spain: Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.Apicomplexa: A phylum of unicellular parasitic EUKARYOTES characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior. (1/3)

This study presents a kinetic characterization of the recently crystallized bifunctional thymidylate synthasedihydrofolate reductase (TS-DHFR) enzyme from the apicomplexa parasite, Cryptosporidium hominis. Our study focuses on determination of the C. hominis TS-DHFR kinetic mechanism, substrate channeling behavior, and domain-domain communication. Unexpectedly, the unique mechanistic features of C. hominis TS-DHFR involve the highly conserved TS domain. At 45 s(-) (1), C. hominis TS activity is 10-40-fold faster than other TS enzymes studied and a new kinetic mechanism was required to simulate C. hominis TS behavior. A large accumulation of dihydrofolate produced at TS and a lag in product formation at DHFR were observed. These observations make C. hominis TS-DHFR the first bifunctional TS-DHFR enzyme studied for which there is clear evidence against dihydrofolate substrate channeling. Furthermore, whereas with Leishmania major TS-DHFR there are multiple lines of evidence for domain-domain communication (ligand binding at one active site affecting activity of the other enzyme), no such effects were observed with C. hominis TS-DHFR.  (+info)

Issue a boil-water advisory or wait for definitive information? A decision analysis. (2/3)

OBJECTIVE: Study the decision to issue a boil-water advisory in response to a spike in sales of diarrhea remedies or wait 72 hours for the results of definitive testing of water and people. METHODS: Decision analysis. RESULTS: In the base-case analysis, the optimal decision is test-and-wait. If the cost of issuing a boil-water advisory is less than 13.92 cents per person per day, the optimal decision is to issue the boil-water advisory immediately. CONCLUSIONS: Decisions based on surveillance data that are suggestive but not conclusive about the existence of a disease outbreak can be modeled.  (+info)

Back to basics: a revealing secondary reduction of the mitochondrial protein import pathway in diverse intracellular parasites. (3/3)

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Roxburgh and Lake Roxburgh Village were put on boil-water notices on Wednesday, while Alexandra was added to the list on Thursday, following high water levels on the Clutha River.. Increased levels meant water supplies were at risk of containing harmful micro-organisms.. People in affected areas should bring tap water to a full rolling boil for one minute and then let it cool before using it.. A Central Otago District Council spokeswoman has also encouraged people to conserve water until the situation improved.. Roxburgh and Lake Roxburgh Village were put on boil-water notices at 5.30pm on Wednesday, while Alexandra was added to the list at 11am yesterday.. The announcements were made after tests showed the water supply to those towns potentially contained harmful micro-organisms, following high water levels on the Clutha River.. As a result, levels of silt were elevated, a council spokeswoman said.. "More rain is forecast, so we need to be cautious.. "Water from the river is entering the ...
Alternative protein import pathways into the peroxisomal matrix 12:00-13:20 Lunch (finger food & cake) 13:20-13:40 Marco Guerreiro (Begerow) ...
On Earth Magazine. When Josie Nieto visits her relatives in Mexicali, Mexico, she luxuriates in long showers. And when shes thirsty, she enjoys a glass of water straight from the kitchen tap. At Nietos own house, the water pressure is so low it can take her 45 minutes to shower and shampoo. And sometimes theres no water at all, which is why some of her neighbors hoard water in buckets. Its fine for laundry and houseplants, but Nieto isnt keen on drinking the stuff. The main pipe of her community water system runs straight down the middle of an irrigation ditch. "Ive seen dead animals in there," Nieto says.. The plastic water pipe itself suffers frequent breaks, which can allow contaminants to seep into the system. Washer screens on fixtures routinely trap sand and flecks of rust; a neighbor without a screen once drew from his tap a tall glass of polliwogs. In response to bacterial spikes, the water-system operator sends out boil-water notices, but boiling when nitrate levels rise would ...
Several areas affected by the wildfires are experiencing electrical outages that may cause water systems to lose pressure and may allow harmful contaminants into water lines, said the Washington State Department of Health. Residents who have lost water pressure should boil their tap water when service is restored. Guidance for customers of affected water systems can be found online.. In order to kill germs, water should be heated to a brisk boil for one minute and allowed to cool before use, the department advises. The boil-water advisory remains in effect until tests show the water is safe to drink. People who are unsure about whether their water is safe to drink should contact their water system.. The department said its also important that people in wildfire areas pay attention to current air quality information, which can be found on the Washington State Department of Ecologys website. Breathing smoke from wildfires can make anyone cough or wheeze, and people who have asthma or another ...
Cryptosporidium spp. are protozoan parasites of the phylum Apicomplexa, class Sporozoasida, subclass Coccidia, order Eucoccidiorida, family Cryptosporidiidae
The translocase of the outer membrane (TOM complex) forms the entry gate for the majority of mitochondrial precursor proteins. Subsequently, specific protein complexes sort the precurcor proteins into the different subcompartments. The presequence translocase (TIM23 complex) transport proteins across and into the inner membrane. The TIM23 complex cooperates with the presequence-translocase associated motor (PAM) for transport into the mitochondrial matrix. The carrier translocase (TIM22 complex) inserts proteins into the inner membrane. The activity of the respiratory chain generates a membrane potential that drives both protein import pathways. The MIA machinery transports cysteine-rich proteins into the intermembrane space. Outer membrane proteins with β-barrel structure are first transported across the TOM machinery and then inserted into the outer membrane by the sorting and assembly machinery (SAM complex). Finally, the mitochondrial import machinery (MIM) promotes biogenesis of outer ...
Relationships among Cryptosporidium hominis and C. parvum multilocus sequence subtypes at 5 genetic loci. Parasite population from Jamaica was compared with tha
SWISS-MODEL Template Library (SMTL) entry for 6pff. Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-cyanobenzoic acid.
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Apicomplexa: Cryptosporidiidae) from Homo sapiens". J. Eukaryot. Microbiol. 49 (6): 433-40. doi:10.1111/j.1550-7408.2002. ...
Apicomplexa: Cryptosporidiidae) from the Red Kangaroo (Macropus rufus)". Journal of Eukaryotic Microbiology. 55 (1): 22-26. doi ...
The first of them - Gregarinomorphea - comprises Orthogregarinia, Cryptosporidiidae and, additionally, Rhytidocystidae ...
1911 Family Aggregatidae Family Calyptosporiidae Family Cryptosporidiidae Léger, 1911 Family Eimeriidae Minchin, 1903 Family ...
... cryptosporidiidae MeSH B01.500.841.075.189.250.150.160 --- cryptosporidium MeSH B01.500.841.075.189.250.150.160.170 --- ...
Cryptosporidiidae (Cryptosporidium). *Eimeriidae (Cyclospora, Eimeria, Isospora). *Elleipsisomatidae. *Lankesterellidae. * ...
Cryptosporidiidae (Cryptosporidium). *Eimeriidae (Cyclospora, Eimeria, Isospora). *Elleipsisomatidae. *Lankesterellidae. * ...
Cryptosporidiidae (Cryptosporidium). *Eimeriidae (Cyclospora, Eimeria, Isospora). *Elleipsisomatidae. *Lankesterellidae. * ...
Cryptosporidiidae (Cryptosporidium). *Eimeriidae (Cyclospora, Eimeria, Isospora). *Elleipsisomatidae. *Lankesterellidae. * ...
Apicomplexa: Cryptosporidiidae) from Homo sapiens. The Journal of Eukaryotic Microbiology, 49 (6). pp. 433-440. ...
Apicomplexa: Cryptosporidiidae) from cultured turbot Scophthalmus maximus. Light and electron microscope description and ...
Apicomplexa: Cryptosporidiidae) from Homo sapiens. J Eukaryot Microbiol 2002;49:433--40. ...
Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals ... Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals ... Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals ... Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals ...
Apicomplexa: Cryptosporidiidae) in domestic mice (Mus musculus)External. . Exp Parasitol. 2012 Mar;130(3):274-81. ... Apicomplexa: Cryptosporidiidae) in domestic mice (Mus musculus)External. . Exp Parasitol. 2012 Mar;130(3):274-81. ...
Apicomplexa: Cryptosporidiidae) from Homo sapiens. J Eukaryot Microbiol. 2002;49:433-40. DOIPubMed ...
Apicomplexa: Cryptosporidiidae): Molecular and Biological Evidence of Cryptic Species within Gastric Cryptosporidium of Mammals ... Racek chechtavý (Larus ridibundus L.), nový hostitel Cryptosporidium baileyi (Apicomplexa: Cryptosporidiidae). [The black- ... n., Cryptosporidium ducismarci Traversa, 2010 and Cryptosporidium tortoise genotype III (Apicomplexa: Cryptosporidiidae) in ... headed gull (Larus ridibundus L.), a new host for Cryptosporidium baileyi (Apicomplexa: Cryptosporidiidae)]. Vet Med (Praha). ...
Familia: Cryptosporidiidae. Genus: Cryptosporidium. Species: C. andersoni - C. bailey - C. canis - C. felis - C. galli - C. ...
Apicomplexa: Cryptosporidiidae) infecting two marine fish species, Sparus aurata L. and Dicentrarchus labrax L. Int. J. ...
APICOMPLEXA - CRYPTOSPORIDIIDAE). Ocampo Gallego, Ricardo José; Cardozo Duque, Luz Adriana; López Garnert, Germán Ariel; ...
Categories: Cryptosporidiidae Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 8 ...
Apicomplexa: Cryptosporidiidae) infecting two marine fish species, Sparus aurata L. and Dicentrarchus labrax L. Int J Parasitol ... Apicomplexa: Cryptosporidiidae) in cattle (Bos taurus). J Parasitol. 2005;91:624-9. https://doi.org/10.1645/GE-3435.CrossRef ... Apicomplexa: Cryptosporidiidae) in pigs (Sus scrofa). J Parasitol. 2004;90:769-73. https://doi.org/10.1645/GE-202R1. ... Apicomplexa: Cryptosporidiidae) in cattle (Bos taurus). Vet Parasitol. 2008;156:191-8. https://doi.org/10.1016/j.vetpar.2008.05 ...
Apicomplexa: Cryptosporidiidae) from Homo sapiens". J. Eukaryot. Microbiol. 49 (6): 433-40. doi:10.1111/j.1550-7408.2002. ...
Apicomplexa: Cryptosporidiidae) in cattle (Bos taurus). J. Parasitol., 91: 624-629.. CrossRef , Direct Link , Fayer, R., M. ... Apicomplexa, Cryptosporidiidae) infecting chickens. J. Protozool., 33: 289-296.. CrossRef , Direct Link , Diaz-Lee, A., R. ...
Enteric protozoans: Cyclospora, Eimeria, Isospora and Cryptosporidium (Cryptosporidiidae) spp. Chapter 16, pp. 416-459,In, ...
Apicomplexa: Cryptosporidiidae) from the Red Kangaroo (Macropus rufus)". Journal of Eukaryotic Microbiology. 55 (1): 22-26. doi ...
Apicomplexa: Cryptosporidiidae) from Homo sapiens. J Eukaryot Microbiol 49:433-440. *Article ...
n., Cryptosporidium ducismarci Traversa, 2010 and Cryptosporidium tortoise genotype III (Apicomplexa: Cryptosporidiidae) in ...
Apicomplexa: Cryptosporidiidae) in sheep (Ovis aries). Vet Parasitol. 2009;146:192-200.View ArticleGoogle Scholar. ...
Apicomplexa: Cryptosporidiidae) among travellers returning to Great Britain from the Indian subcontinent, 2007-2011. Int. J. ...
Cryptosporidiosis is caused by protozoan parasites of the genus Cryptosporidium (family Cryptosporidiidae, order Eucoccidiorida ...
1990) Identification of outer oocyst wall proteins of three Cryptosporidium (Apicomplexa: Cryptosporidiidae) species by 125I ... 1990) Electrophoretic characterization of Cryptosporidium parvum (KSU-1 isolate) (Apicomplexa: Cryptosporidiidae). Can. J. Zool ...
The black-headed gull (Larus ridibundus L.), a new host for Cryptosporidium baileyi (Apicomplexa: Cryptosporidiidae). Vet. Med ...
A genus of coccidian parasites of the family CRYPTOSPORIDIIDAE, found in the intestinal epithelium of many vertebrates ... genus of coccidian parasites of the family Cryptosporidiidae, found in the intestinal epithelium of many vertebrates including ...
Apicomplexa: Cryptosporidiidae) among travellers returning to Great Britain from the Indian subcontinent, 2007-2011. Int J ... n. (Apicomplexa: Cryptosporidiidae) in Apodemus spp. Eur J Protistol. 2018;63:1-12. ... n. (Apicomplexa: Cryptosporidiidae) in Psittaciformes birds. Eur J Protistol. 2019;69:70-87. ... n. (Apicomplexa: Cryptosporidiidae) in rats. Eur J Protistol. 2018;63:96-104. ...