Cryptococcus neoformans
Cryptococcus
Cryptococcus gattii
Meningitis, Cryptococcal
Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
Antifungal Agents
Melanins
Lung Diseases, Fungal
Genes, Mating Type, Fungal
Fluconazole
Laccase
A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.
Virulence
Meningoencephalitis
Amphotericin B
Gene Expression Regulation, Fungal
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Phagocytosis
Serotyping
Drug Resistance, Fungal
Microbial Sensitivity Tests
Mycology
Candida
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Itraconazole
Lysophospholipase
Candida albicans
Cell Wall
Environmental Microbiology
Central Nervous System Fungal Infections
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Virulence Factors
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Fungal Capsules
Pheromones
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Fungal Vaccines
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Columbidae
Lung
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Yeasts
Cerebrospinal Fluid
Haploidy
Fungal Polysaccharides
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Hyphae
Opsonin Proteins
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Meningitis, Fungal
Orotate Phosphoribosyltransferase
Random Amplified Polymorphic DNA Technique
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Eucalyptus
Fruiting Bodies, Fungal
Histoplasma
Blastomyces
DNA Fingerprinting
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Macrophages, Alveolar
Urease
Gene Deletion
Sterol 14-Demethylase
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Acanthamoeba castellanii
BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. (1/1887)
A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells. (+info)In-vivo therapeutic efficacy in experimental murine mycoses of a new formulation of deoxycholate-amphotericin B obtained by mild heating. (2/1887)
Heat-induced 'superaggregation' of deoxycholate-amphotericin B (AmB-DOC, Fungizone) was shown previously to reduce the in-vitro toxicity of this antifungal agent. We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungizone, Bristol Myers Squibb, Paris, France) for 20 min at 70 degrees C, in the treatment of murine infections. An improvement of antifungal activity was obtained with heated AmB-DOC formulations due to a lower toxicity which allowed the administration of higher drug doses than those achievable with the commercial preparation. Single intravenous injections of heated AmB-DOC solutions were demonstrated to be two-fold less toxic than unheated ones to healthy mice. For mice infected with Candida albicans, the maximum tolerated dose was higher with heated than with unheated AmB-DOC solutions. In the model of murine candidiasis, following a single dose of heated AmB-DOC 0.5 mg/kg, 85% of mice survived for 3 weeks, whereas at this dose the immediate toxicity of the standard formulation in infected mice restricted the therapeutic efficacy to 25% survival. Both formulations were equally effective in increasing the survival time for murine cryptococcal pneumonia and meningoencephalitis. Injection of heated AmB-DOC solutions at a dose two-fold higher than the maximal tolerated dose observed with the unheated preparation (1.2 mg/kg) increased the survival time by a factor of 1.4 in cryptococcal meningoencephalitis. These results indicate that mild heat treatment of AmB-DOC solutions could provide a simple and economical method to improve the therapeutic index of this antifungal agent by reducing its toxicity on mammalian cells. (+info)Variants of a Cryptococcus neoformans strain elicit different inflammatory responses in mice. (3/1887)
The virulence of Cryptococcus neoformans isolates with high and low extracellular proteolytic activity was investigated in mice. No consistent relationship between proteolytic activity and virulence was observed, but isolates derived from one strain were shown to elicit different inflammatory responses. (+info)Serotyping of Cryptococcus neoformans isolates from clinical and environmental sources in Spain. (4/1887)
We determined biovars and serotypes of 154 isolates of Cryptococcus neoformans from clinical and environmental sources from different areas of Spain. All clinical isolates belonged to C. neoformans var. neoformans. Serotypes showed an irregular distribution. C. neoformans var. gattii serotype B was isolated from necropsy specimens from goats with pulmonary disease. (+info)Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. (5/1887)
Synthetic green fluorescent protein (GFP) was used as a reporter to detect differential gene expression in the pathogenic fungus Cryptococcus neoformans. Promoters from the C. neoformans actin, GAL7, or mating-type alpha pheromone (MFalpha1) genes were fused to GFP, and the resulting reporter genes were used to assess gene expression in serotype A C. neoformans. Yeast cells containing an integrated pACT::GFP construct demonstrated that the actin promoter was expressed during vegetative growth on yeast extract-peptone-dextrose medium. In contrast, yeast cells containing the inducible GAL7::GFP or MFalpha1::GFP reporter genes expressed significant GFP activity only during growth on galactose medium or V-8 agar, respectively. These findings demonstrated that the GAL7 and MFalpha1 promoters from a serotype D C. neoformans strain function when introduced into a serotype A strain. Because the MFalpha1 promoter is induced by nutrient deprivation and the MATalpha locus containing the MFalpha1 gene has been linked with virulence, yeast cells containing the pMFalpha1::GFP reporter gene were analyzed for GFP expression in the central nervous system (CNS) of immunosuppressed rabbits. In fact, significant GFP expression from the MFalpha1::GFP reporter gene was detected after the first week of a CNS infection. These findings suggest that there are temporal, host-specific cues that regulate gene expression during infection and that the MFalpha1 gene is induced during the proliferative stage of a CNS infection. In conclusion, GFP can be used as an effective and sensitive reporter to monitor specific C. neoformans gene expression in vitro, and GFP reporter constructs can be used as an approach to identify a novel gene(s) or to characterize known genes whose expression is regulated during infection. (+info)Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis. (6/1887)
Cryptococcus neoformans causes infection in individuals with defective T cell function, such as AIDS, as well as without underlying disease. It has been suggested that humoral as well as cellular immunity might play an important role in the immune response to C. neoformans infection. We have recently shown, using immunoblotting, that the 70-kD hsp family of C. neoformans was the major target molecule of the humoral response in murine pulmonary cryptococcosis. In this study we also used immunoblotting to define the antibody responses in the sera of 24 patients with pulmonary cryptococcosis: 21 proven and three suspected diagnoses. Anti-C. neoformans hsp70 antibody was detected in 16 of 24 (66.7%) patients with pulmonary cryptococcosis. Fourteen of 17 (82.3%) patients with high antigen titres (> or = 1:8) and two of seven (28.6%) patients with low titres (< or = 1:4) had detectable levels of anti-hsp70 antibody. Sera from patients positive for anti-hsp70 antibody showed high titres in the Eiken latex agglutination test for the detection of serum cryptococcal antigen. Our results indicate that the 70-kD hsp family from C. neoformans appears to be a major target molecule of the humoral response, not only in murine pulmonary cryptococcosis, but also in human patients with pulmonary cryptococcosis. (+info)Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. (7/1887)
Activated T lymphocytes play a crucial role in orchestrating cellular infiltration during a cell-mediated immune (CMI) reaction. TCA3, a C-C chemokine, is produced by Ag-activated T cells and is chemotactic for neutrophils and macrophages, two cell types in a murine CMI reaction. Using a gelatin sponge model for delayed-type hypersensitivity (DTH), we show that TCA3 is a component of the expression phase of an anticryptococcal CMI response in mice. TCA3 mRNA levels are augmented in anticryptococcal DTH reactions at the same time peak influxes of neutrophils and lymphocytes are observed. Neutralization of TCA3 in immunized mice results in reduced numbers of neutrophils and lymphocytes at DTH reaction sites. However, when rTCA3 is injected into sponges in naive mice, only neutrophils are attracted into the sponges, indicating TCA3 is chemotactic for neutrophils, but not lymphocytes. We show that TCA3 is indirectly attracting lymphocytes into DTH-reactive sponges by affecting at least one other chemokine that is chemotactic for lymphocytes. Of the two lymphocyte-attracting chemokines assessed, monocyte-chemotactic protein-1 and macrophage-inflammatory protein-1alpha (MIP-1alpha), only MIP-1alpha was reduced when TCA3 was neutralized, indicating that TCA3 affects the levels of MIP-1alpha, which attracts lymphocytes into the sponges. TCA3 also plays a role in protection against Cryptococcus neoformans in the lungs and brains of infected mice, as evidenced by the fact that neutralization of TCA3 results in increased C. neoformans CFU in those two organs. (+info)Antibody response to Cryptococcus neoformans proteins in rodents and humans. (8/1887)
The prevalence and specificity of serum antibodies to Cryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcosis, in matched samples from HIV-positive individuals who did not develop cryptococcosis, and in HIV-negative individuals. Rodents had little or no serum antibody reactive with C. neoformans proteins prior to infection. The intensity and specificity of the rodent antibody response were dependent on the species, the mouse strain, and the viability of the inoculum. All humans had serum antibodies reactive with C. neoformans proteins regardless of the potential exposure, the HIV infection status, or the subsequent development of cryptococcosis. Our results indicate (i) a high prevalence of antibodies reactive with C. neoformans proteins in the sera of rodents after cryptococcal infection and in humans with or without HIV infection; (ii) qualitative and quantitative differences in the antibody profiles of HIV-positive individuals; and (iii) similarities and differences between humans, mice, and rats with respect to the specificity of the antibodies reactive with C. neoformans proteins. The results are consistent with the view that C. neoformans infections are common in human populations, and the results have implications for the development of vaccination strategies against cryptococcosis. (+info)Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both...
Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans | Microbiology Society
The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by...
Radial mass density, charge, and epitope distribution in the Cryptococcus neoformans capsule<...
Quimiotipagem do Cryptococcus neoformans. Revisão da literatura. Novos dados epidemiológicos sobre a criptococose. Nossa...
First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe...
Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum<...
Cryptococcus neoformans var. grubii Franzot et al. ATCC ® 208821D
Molecular typing of Cryptococcus neoformans serotype D clinical isolates • Research - Institut Pasteur
Antibody-mediated immobilization of Cryptococcus neoformans promotes biofilm formation<...
RNA Interference in the Pathogenic Fungus Cryptococcus neoformans | Genetics
Aspects of antigen mimicry revealed by immunization with a peptide mimetic of Cryptococcus neoformans polysaccharide. -...
Isolation of the Third Capsule-Associated Gene,CAP60, Required for Virulence in Cryptococcus neoformans | Infection and Immunity
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease<...
Resistance of Asian Cryptococcus neoformans Serotype A Is Confined to Few Microsatellite Genotypes
Cyclic AMP-Dependent Protein Kinase Controls Virulence of the Fungal Pathogen Cryptococcus neoformans | Molecular and Cellular...
Antibody Response to Cryptococcus neoformans Capsular Polysaccharide Glucuronoxylomannan in Patients after Solid-Organ...
Table 3 - Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and...
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans<...
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
Cryptococcus neoformans - Wikipedia
KEGG GENOME: Cryptococcus neoformans var. neoformans B-3501A
Cryptococcus neoformans CAP59 protein
Summary Report | CureHunter
JCI -
Pathogen-specific antibodies: codependent no longer
JCI -
Pathogen-specific antibodies: codependent no longer
Serotypes of Cryptococcus neoformans<...
More information about the natural habitat of Cryptococcus neoformans<...
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans • Research - Institut Pasteur
Major Histocompatibility Complex-Dependent Susceptibility to Cryptococcus neoformans in Mice | Infection and Immunity
The role of Notch signaling in host defenses to Cryptococcus neoformans (P3310) | The Journal of Immunology
Frontiers | TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary...
GSE17686 - Transcriptomic analysis comparing the spontaneous acapsular strain AL1114 to the parent capsulated strain AL1115 -...
Role of dectin-1 in the host defense to infection with Cryptococcus neoformans (44.17) | The Journal of Immunology
Cryptococcus neoformans variety gattii. - PubMed - NCBI
reagents-molecular-assay-infection-fungiyeast-cryptococcus-neoformans
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. - Kent Academic...
Evidence of Sexual Recombination among Cryptococcus neoformans Serotype A Isolates in Sub-Saharan Africa | Eukaryotic Cell
Increasing in vitro resistance to fluconazole in Cryptococcus neoformans Cambodian isolates: April 2000 to March 2002 : Journal...
A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans.
Pheromones and Titan Cell Production in Cryptococcus neoformans - Kirsten Nielsen
Jawaharlal Nehru Centre for Advanced Scientific Research
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans<...
Natural habitat of Cryptococcus neoformans var. gattii. | Journal of Clinical Microbiology
Produção de fatores de virulência in vitro por isolados de Cryptococcus neoformans e Cryptococcus gattii de origem clínica em...
Mapping of the Cryptococcus neoformans MATα locus: Presence of mating type-specific mitogen-activated protein kinase cascade...
Cryptococcosis Market: Competitive Dynamics & Global Outlook 2024 - BizPR.us | US Free Press Release and Distribution center
UBIRA ETheses - How does the expression of phospholipase B influence the host pathogen relationship between Cryptococcus...
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. | Journal of Experimental Medicine | Rockefeller...
ANTIMICROBIAL POLYMERS AND METHODS OF MANUFACTURE THEREOF - Patent application
Growth and Pigment Production on d-Tryptophan Medium by Cryptococcus gattii, Cryptococcus neoformans, and Candida albicans |...
Clinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology Laboratory
Cryptococcosis: Its Prevalence and Clinical Presentation among Hiv Positive and Negative Patients in Rims, Manipur - Semantic...
Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway...
Cryptococcosis - Wikipedia
Cryptococcus | Article about Cryptococcus by The Free Dictionary
Cutaneous Cryptococcus Publications and Abstracts | PubFacts.com
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans | AVESİS
Browse by Author/Supervisor - eTheses Repository
A prospective descriptive study of cryptococcal meningitis in HIV unifected patients in Vietnam - high prevalence of...
JCI -
Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans
Forecasting Fatal Fungal Infections - Redorbit
ASMscience | Molecular Typing of the
Cryptococcal encephalitis in thermally injured mice is accelerated by type 2 T-cell responses<...
Calcineurin is required for virulence of Cryptococcus neoformans | The EMBO Journal
Dr. Erin E. McClelland | Faculty | Middle Tennessee State University
azole resistance mechanisms in clinical isolates of Candida albicans and Cryptococcus neoformans from intensive care patients |...
Cyclosporine Capsule size: 100 mg at PetSmart in Dover - 70558734
Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with...
PREPARATION DIFFERENTIAL CULTURE MEDIUM FOR CRYPTOCOCCUS NEOFORMANS FROM AQUEOUS EXTRACT OF LEAVES AND FLOWERS OF CHRYSANTHEMUM...
Cryptococcus neoformans meningitis in a diabetic patient - the perils of an overzealous immune response: a case report
Home - Cryptococcus wieringae v1.0
Compare Current Fungal+Meningitis+Caused+By+Cryptococcus Drugs and Medications with Ratings & Reviews
ASMscience | Hybridization and Its Im
Differentiation of Naturally Produced Extracellular ...
Cryptococcosis
Three Klebsiella species cause life-threatening infections and share drug resistance genes | EurekAlert! Science News
Filobasidiella neoformans Kwon-Chung, teleomorph ATCC ® 34873&trad
Capsule Sizes: Empty Cap Chart w/ mg & ml Info
Pissin On The Roses: Complex Systems: Origin of Virulence; Chaos, & Radioactive Black Dirt
LSHTM Research Online
Postdoctoral position in Medical Mycology
Cryptococcosis Medication: Antifungal agents
2018 ICD-10-CM Codes B45*: Cryptococcosis
Biology-Online • View topic - The Fiber Disease
Cryptococcus neoformans
... meaning that Filobasidiella neoformans became a synonym of the earlier name Cryptococcus neoformans. Cryptococcus neoformans ... Media related to Cryptococcus neoformans at Wikimedia Commons A good overview of Cryptococcus neoformans biology from the ... neoformans var. grubii. A new species name, Cryptococcus deneoformans, is used for the former C. neoformans var. neoformans. C ... Cryptococcus neoformans can cause disease in apparently immunocompetent, as well as immunocompromised, hosts. Cryptococcus ...
Cryptococcus
... neoformans sensu stricto and Cryptococcus deneoformans. Cryptococcus gattii (formerly C. neoformans var. gattii) ... Cogliati M (2013). "Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular ... 2015). "Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex". Fungal Genetics and ... Filobasidiella neoformans, by crossing strains of the yeast Cryptococcus neoformans. She was able to observe basidia similar to ...
Arturo Casadevall
Cryptococcus neoformans var. grubii: separate varietal status for Cryptococcus neoformans serotype A isolates, in: Journal of ... 1998, Cryptococcus neoformans. with co-author John R. Perfect, ASM Press. Highly Cited Articles 2020, with Liise-anne Pirofski ... He has defined much of what is known about fungal pathogenesis and how fungi such as Cryptococcus neoformans evade the host ... Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic ...
Rhoda Williams Benham
... which she termed Cryptococcus. Her subsequent publication in 1950 established Cryptococcus neoformans as the formally accepted ... The terminology of the cryptococci with a note on Cryptococcus mollis. Mycologia 27: 496-502. 1935. Cryptococci-their ... Cryptococcus neoformans: "an ascomycete." Proc. Soc. Exp. Biol. Med. 89. 243-245. 1955. Trichophyton rubrum infections: a ... With J. L. Miranda.) Chemical analysis of the capsular substance of Cryptococcus neoformans. Jour. Invest. Dermat. 22: 279-283 ...
Cryptococcus gattii
... , formerly known as Cryptococcus neoformans var. gattii, is an encapsulated yeast found primarily in ... "Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex". Fungal Genetics and Biology. ... neoformans species complex. Molecular techniques may be used to speciate Cryptococcus from specimens that fail to culture. ... Unlike Cryptococcus neoformans, C. gattii is not particularly associated with human immunodeficiency virus infection or other ...
Fever of unknown origin
Cryptococcus neoformans. Cancer can also cause fever of unknown origin. This is thought to be due to release of pyrogenic ...
Gene density
"Cryptococcus neoformans (ID 61) - Genome - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-12-14. "Index of /genomes/refseq/fungi/ ... "Index of /genomes/refseq/fungi/Cryptococcus_neoformans/latest_assembly_versions/GCF_000091045.1_ASM9104v1". ftp.ncbi.nih.gov. ...
Tremella mesenterica
Cherniak R, Jones RG, Slodki ME (1988). "Type-specific polysaccharides of Cryptococcus neoformans. N.M.R.-spectral study of a ... Slodki ME, Wickerham LJ, Bandoni RJ (1966). "Extracellular heteropolysaccharides from Cryptococcus and Tremella: a possible ... mesenterica that closely resembled those produced by the species Cryptococcus laurentii. The structural similarity of the ...
Bacterial capsule
The yeast Cryptococcus neoformans, though not a bacterium, has a similar capsule. Capsules too small to be seen with an ... Casadevall A, Coelho C, Cordero RJ, Dragotakes Q, Jung E, Vij R, Wear MP (December 2019). "Cryptococcus neoformans". Virulence ... O'Meara TR, Alspaugh JA (July 2012). "The Cryptococcus neoformans capsule: a sword and a shield". Clinical Microbiology Reviews ... Gates MA, Thorkildson P, Kozel TR (April 2004). "Molecular architecture of the Cryptococcus neoformans capsule". Molecular ...
Tremellales
2004). "Genetic requirements for virulence in Cryptococcus neoformans". In Domer JE, Kobayashi GS (eds.). Human Fungal ... Molecular research has also indicated that the genus Cryptococcus should be included within the group, even though species do ... and the yeast genus Cryptococcus, several species of which are human pathogens. The order Tremellales was created (as ' ...
Pathogenic fungus
The majority of Cryptococcus species live in the soil and do not cause disease in humans. Cryptococcus neoformans is the major ... Lin X, Hull CM, Heitman J (2005). "Sexual reproduction between partners of the same mating type in Cryptococcus neoformans". ... Fan W, Kraus PR, Boily MJ, Heitman J (2005). "Cryptococcus neoformans gene expression during murine macrophage infection". ... Alspaugh JA, Granger DL (1991). "Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of ...
Fungus
Cryptococcus neoformans is an encapsulated yeast that can live in both plants and animals. C. neoformans usually infects the ... Perfect JR (June 2006). "Cryptococcus neoformans: the yeast that likes it hot". FEMS Yeast Research. 6 (4): 463-8. doi:10.1111/ ... Fan W, Kraus PR, Boily MJ, Heitman J (August 2005). "Cryptococcus neoformans gene expression during murine macrophage infection ... Cryptococcus neoformans. Because of similarities in morphology and lifestyle, the slime molds (mycetozoans, plasmodiophorids, ...
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase
"A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans". The Journal of Biological Chemistry. 284 (52 ...
Carlyn Halde
Halde, C.; Fraher, M. A. (1966-03-01). "Cryptococcus neoformans in pigeon feces in San Francisco". California Medicine. 104 (3 ...
Immune reconstitution inflammatory syndrome
IRIS has been described in immunocompetent hosts who have meningitis caused by Cryptococcus gattii and Cryptococcus neoformans ... Lane, M.; McBride, J.; Archer, J. (23 August 2004). "Steroid responsive late deterioration in Cryptococcus neoformans variety ... in whom Cryptococcus neoformans is the usual pathogen. Treatment with systemic corticosteroids during IRIS may be beneficial in ... "Paradoxical Inflammatory Reaction during Treatment of Cryptococcus neoformans var. gattii Meningitis in an HIV-Seronegative ...
Ptilomycalin A
"Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans". Bioorg Med Chem. 19 (22): 6654-7. doi:10.1016/j. ...
Katherine Franz
She has looked at iron and copper as ionophores; which are important in the virulence of Cryptococcus neoformans. Franz also ...
Nigrosin
as well as the capsule-containing fungus Cryptococcus neoformans. The shapes and sizes of the organisms are seen as color-free ...
Laccase
"Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans". mBio. 10 (5): e02267-19. doi:10.1128/mBio. ...
Yeast
Cryptococcus neoformans and Cryptococcus gattii are significant pathogens of immunocompromised people. They are the species ... Cogliati M (2013). "Global molecular epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An atlas of the molecular ... O'Meara TR, Alspaugh JA (2012). "The Cryptococcus neoformans capsule: A sword and a shield". Clinical Microbiology Reviews. 25 ...
Propagule
Ellis, David; Pfeiffer, Tania (1990-10-13). "Ecology, life cycle, and infectious propagule of Cryptococcus neoformans". The ...
Opportunistic infection
"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis". Cold Spring Harbor Perspectives in ... Cryptococcus neoformans is a fungus that causes cryptococcosis, which can lead to pulmonary infection as well as nervous system ...
Intracellular parasite
Cryptococcus neoformans Obligate intracellular parasites cannot reproduce outside their host cell, meaning that the parasite's ... Alvarez, M.; Burns, T.; Luo, Y.; Pirofski, L. A.; Casadevall, A. (2009). "The outcome of Cryptococcus neoformans intracellular ...
Phagolysosome
"Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages". Infection and Immunity. 67 (2): 885-890. ISSN ...
Major histocompatibility complex and sexual selection
"Major Histocompatibility Complex-Dependent Susceptibility to Cryptococcus neoformans in Mice". Infection and Immunity. 71 (8): ...
Basidiomycota
Cryptococcus neoformans and Cryptococcus gattii. The dimorphic Basidiomycota with yeast stages and the pleiomorphic rusts are ... Cryptococcus neoformans and Ustilago maydis are examples of pathogenic basidiomycota. Such pathogens must be able to overcome ... "Sexual reproduction between partners of the same mating type in Cryptococcus neoformans". Nature. 434 (7036): 1017-21. Bibcode: ... The ability of C. neoformans and U. maydis to undergo meiosis may contribute to their virulence by repairing the oxidative DNA ...
Mucicarmine stain
One of the organisms that is identified using this staining technique is Cryptococcus neoformans. Another use is in surgical ... Lazcano, O (Jan 1993). "Combined histochemical stains in the differential diagnosis of Cryptococcus neoformans". Modern ...
Histatin
Tsai H, Bobek LA (October 1997). "Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans ... and Cryptococcus neoformans. Histatins also precipitate tannins from solution, thus preventing alimentary adsorption. Histatins ...
Joseph Heitman
Hull, CM, Davidson, RC, Heitman, J (December 2002). "Cell identity and sexual development in Cryptococcus neoformans are ... "Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes". Eukaryotic Cell. 1 (5): 704-718. doi ... "Sexual reproduction between partners of the same mating type in Cryptococcus neoformans". Nature. 434 (7036): 1017-21. Bibcode: ... "Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi". Genes & Development. 24 (22): 2566-82. doi: ...
List of sequenced fungi genomes
February 2005). "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans". Science. 307 (5713): 1321 ... Cryptococcus (Filobasidiella) neoformans JEC21, human pathogen (2005, other strains unpubl.) Dacryopinax sp. (2012) Tremella ...
GNLY
"CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15". Journal ...
List of MeSH codes (B05)
... cryptococcus MeSH B05.381.258.366 - cryptococcus neoformans MeSH B05.381.340 - epidermophyton MeSH B05.381.355 - exophiala MeSH ... cryptococcus MeSH B05.930.316.366 - cryptococcus neoformans MeSH B05.930.536 - kluyveromyces MeSH B05.930.574 - malassezia MeSH ...
Radiosynthesis (metabolism)
... and that Cryptococcus neoformans fungi grew three times faster than normal. Microbiologist Ekaterina Dadachova suggested such ...
BZIP intron RNA motif
Cryptococcus neoformans, Ustilago maydis Plants: Arabidopsis thaliana, maize. Computational methods predict a bZIP intron with ... for Controlling Pathogenicity of Cryptococcus neoformans". PLOS Pathogens. 7 (8): e1002177. doi:10.1371/journal.ppat.1002177. ...
Calcofluor-white
... and Cryptococcus neoformans. CFW staining of Pneumocystis carinii in lung biopsies can be optimized by initial CFW at room ...
Meningoencephalitis
The fungus, Cryptococcus neoformans, can be symptomatically manifested within the CNS as meningoencephalitis with hydrocephalus ...
Angophora costata
Aulographina eucalypti and Cryptococcus neoformans. Smooth-barked apple grows well in a variety of situations and can be easily ...
Mating of yeast
Cryptococcus neoformans is a basidiomycetous fungus that grows as a budding yeast in culture and in an infected host. C. ... "Sexual reproduction between partners of the same mating type in Cryptococcus neoformans". Nature. 434 (7036): 1017-21. Bibcode: ... suggested that one benefit of meiosis in C. neoformans could be to promote DNA repair in a DNA damaging environment that could ... The vast majority of environmental and clinical isolates of C. neoformans are mating type α. Filaments ordinarily have haploid ...
Pseudogymnoascus destructans
... virulence factors in pathogenic environmental fungi-the Cryptococcus neoformans paradigm". Current Opinion in Microbiology. 6 ( ...
House crow
They have also been found to carry Cryptococcus neoformans, which can cause cryptococcosis in humans. House crows in Tanzania ... serotypes and mating patterns of Cryptococcus neoformans in the pellets of different avifauna in Madras, India. Mycoses, 47:310 ...
Tetrazole
Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent Activity against Cryptococcus neoformans and Cryptococcus ...
Flucytosine
... by mouth is used for the treatment of serious infections caused by susceptible strains of Candida or Cryptococcus neoformans. ... Flucytosine is active in vitro as well as in vivo against some strains of Candida and Cryptococcus. Limited studies demonstrate ...
Eugenia calycina
... towards Cryptococcus gattii L48, Cryptococcus neoformans L3 (MIC=31.2μg/mL), and Cryptococcus sp. D (MIC=62.5μg/mL). Therefore ... were revealed to show activity against Cryptococcus sp. D (minimum inhibitory concentration=15.62μg/mL). It was also revealed ...
Naganishia albida
... is very similar to Cryptococcus neoformans, but can be differentiated because it is phenol oxidase-negative, ... "Cryptococcus albidus". Mycology Online. The University of Adelaide. Archived from the original on 2004-06-30. v t e (Articles ... Naganishia albida (synonym Cryptococcus albidus) is a species of fungus in the family Filobasidiaceae. It is currently only ... "Cryptococcus albidus". Dr. Fungus. Archived from the original on 2010-11-06. Labrecque O, Sylvestre D, Messier S (January 2005 ...
Jean Paul Vuillemin
... was named Saccharomyces hominis by Otto Busse and Saccharomyces neoformans by Francesco Sanfelice to the genus Cryptococcus due ...
Clausena anisata
Candida krusei and Cryptococcus neoformans. A methanolic extract from the roots shows molluscicidal results in Bulinus globosus ...
MTOR inhibitors
Aspergillus fumigatus and Cryptococcus neoformans. A few years later its immunosuppressive properties were detected. Later ...
Fungivore
Examples of necrotrophs include Staphylococcus aureus which feed on Cryptococcus neoformans, Aeromonas caviae which feed on ...
Cryptococcus neoformans (Sanfelice) Vuillemin - 96911 | ATCC
Cryptococcus neoformans (Sanfelice) Vuillemin, anamorph Synonyms. Cryptococcus neoformans var. shanghaiensis Liao, Torula ... To download a certificate of origin for Cryptococcus neoformans (Sanfelice) Vuillemin (96911), enter the lot number exactly as ... To download a certificate of analysis for Cryptococcus neoformans (Sanfelice) Vuillemin (96911), enter the lot number exactly ... The certificate of analysis for that lot of Cryptococcus neoformans (Sanfelice) Vuillemin (96911) is not currently available ...
The role of macrophages in the susceptibility of Fc gamma receptor IIb deficient mice to Cryptococcus neoformans | Scientific...
These results support, at least in part, a model whereby, in FcγRIIb−/− mice, enhanced C. neoformans transmigration occurs ... Mortality, after intravenous C. neoformans-induced cryptococcosis, in young (8-week-old) and older (24-week-old) FcγRIIb−/− ... When administered to wild-type mice, FcγRIIb−/− macrophages with phagocytosed Cryptococcus resulted in higher fungal burdens ... In vitro Cryptococcus neoformans-induced macrophage cytokine production. Heat-killed C. neoformans, (immersion in a 60 °C water ...
Image: Cryptococcus neoformans, tissue smear - Merck Veterinary Manual
PRIME PubMed | Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from...
neoformans. Download Prime PubMed App to iPhone, iPad, or Android ... Cryptococcus_neoformans_does_not_differ_clinically_from_proven_ ... Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven ... caused by capsule-deficient Cryptococcus neoformans with those of six patients with PC caused by capsule-intact Cr. neoformans ... caused by capsule-deficient Cryptococcus neoformans with those of six patients with PC caused by capsule-intact Cr. neoformans ...
WHO EMRO | Case report: Cryptococcus neoformans var. gattii meningitis in Egypt: a case report | Volume 12, issue 1/2 | EMHJ...
... neoformans var. grubii (serotype A), C. neoformans var. neoformans (serotype D) and C. neoformans var. gattii (serotypes B and ... Characterization of Cryptococcus neoformans var. neoformans serotype A and A/D in samples from Egypt. Folia microbiologica, ... neoformans var. gattii occurs more commonly in otherwise healthy patients while C. neoformans var. neoformans occurs more often ... Cryptococcus neoformans variety gattii. Medical mycology, 2001, 39:155-68.. *Chen S et al. Epidemiology and host- and variety- ...
UGE1 and UGE2 regulate the UDP-glucose/UDP-galactose equilibrium in Cryptococcus neoformans - Research - Institut Pasteur
UGE1 and UGE2 regulate the UDP-glucose/UDP-galactose equilibrium in Cryptococcus neoformans. ... The genome of the basidiomycete pathogenic yeast Cryptococcus neoformans carries two UDP-glucose epimerase genes (UGE1 and UGE2 ... Here, we show that UGE2 is necessary for C. neoformans cells to utilize galactose as a carbon source at 30 degrees C but is not ...
Epidemiologic differences among serotypes of Cryptococcus neoformans<...
keywords = "Cryptococcus neoformans, Pigeons, Serotyping",. author = "Bennett, {John E.} and Kwon-Chung, {K. J.} and Howard, { ... Bennett, John E. ; Kwon-Chung, K. J. ; Howard, Dexter H. / Epidemiologic differences among serotypes of Cryptococcus neoformans ... Bennett, J. E., Kwon-Chung, K. J., & Howard, D. H. (1977). Epidemiologic differences among serotypes of Cryptococcus neoformans ... Epidemiologic differences among serotypes of Cryptococcus neoformans. / Bennett, John E.; Kwon-Chung, K. J.; Howard, Dexter H. ...
Cryptococcus neoformans survive and replicate in human microglia<...
title = "Cryptococcus neoformans survive and replicate in human microglia",. abstract = "BACKGROUND: Cryptococcus neoformans ( ... Cryptococcus neoformans survive and replicate in human microglia. S. C. Lee, Y. Kress, M. L. Zhao, D. W. Dickson, A. Casadevall ... Cryptococcus neoformans survive and replicate in human microglia. / Lee, S. C.; Kress, Y.; Zhao, M. L. et al. ... Cryptococcus neoformans survive and replicate in human microglia. In: Laboratory Investigation. 1995 ; Vol. 73, No. 6. pp. 871- ...
Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. | [email protected]
Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. ... Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. Journal Article (Journal ... The C. neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little ... induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans ...
Comparison of clinical and biological characteristics of HIV-infected patients presenting Cryptococcus neoformans versus C....
... neoformans (Cn) versus C. curvatus/C. laurentii (Cc/Cl) meningitis. Comparative analytical study were conducted. Apart from ... Cryptococcal meningitis is mainly caused by Cryptococcus neoformans/C. gattii complex. We compared the clinical, biological, ... From: Comparison of clinical and biological characteristics of HIV-infected patients presenting Cryptococcus neoformans versus ...
What makes Cryptococcus neoformans a pathogen?
Prevalence of Cryptococcus neoformans in pigeon habitats Cite CITE. Title : Prevalence of Cryptococcus neoformans in pigeon ... Title : What makes Cryptococcus neoformans a pathogen? Personal Author(s) : Buchanan, K. L.;Murphy, J. W.; Published Date : ... Cryptococcus gattii and C. neoformans cause pulmonary and systemic cryptococcosis. Recently, C. gattii was recognized as a ... Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily ...
"The <i>Cryptococcus neoformans</i> Flc1 Homologue Controls Calcium Hom" by Piotr R. Stempinski, Kristie D....
Here, we report that deletion of C. neoformans FLC1 results in cytosolic calcium elevation and increased nuclear content of ... Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of stress response pathways that allow ... The Cryptococcus neoformans Flc1 Homologue Controls Calcium Homeostasis and Confers Fungal Pathogenicity in the Infected Hosts ... Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of stress response pathways that allow ...
Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context - MORU Tropical...
Cryptococcus neoformans var grubii gca 002222135 - Ensembl Genomes 55
About Cryptococcus neoformans var. grubii str. CM50 (GCA_002222135) Cryptococcus neoformans is an encapsulated yeast and an ... Cryptococcus neoformans var. grubii str. CM50 (Cryp_neof_grubii_cng1_V1) ▼ Favourite species. *Saccharomyces cerevisiae ... Cryptococcus neoformans is an encapsulated fungal organism and it can cause disease in apparently immunocompetent, as well as ... Cryptococcus neoformans var. neoformans B-3501A. *Cryptococcus neoformans var. neoformans JEC21. *Cryptococcus wingfieldii CBS ...
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí ...
Throughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the ... GENOTYPES OF CRYPTOCOCCUS NEOFORMANS AND CRYPTOCOCCUS GATTII AS AGENTS OF ENDEMIC CRYPTOCOCCOSIS IN TERESINA, PIAUÍ ( ... Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí ( ... Our results provide new information on the molecular epidemiology of C. neoformans and C. gattii in Brazilian endemic areas.. ...
Horse: a potential source of Cryptococcus neoformans and Cryptococcus gattii in Egypt | BMC Veterinary Research | Full Text
Bacteriological examination and the identification of Cryptococcus spp. were performed. Molecular serotyping of Cryptococcus ... Cryptococcus spp. represents a potential risk for immunosuppressed and healthy persons. In Egypt, epidemiological data on ... The current study was carried out to investigate the occurrence of Cryptococcus spp. in horses and its possible role in the ... isolates recovered from the nasal passages of horses proved that C. gattii (B), C. neoformans, and two hybrids between C. ...
cryptococcus neoformans
... (es); Cryptococcus neoformans (szl); Cryptococcus neoformans (eu); Cryptococcus neoformans (ast); ... Cryptococcus neoformans - Cryptococcus neoformans. Cryptococcus neoformans and Candida albicans, 4. اسماء جميع الأمراض التي ... John E. . Cryptococcus Neoformans. . Cryptococcosis ( Cryptococcus neoformans and Cryptococcus gattii). neoformans. . تقنيات ... neoformans are similar is unknown. Keywords Cryptococcus neoformans . Cryptococcus neoformans - Especie de hongo levaduriforme ...
Information for Healthcare Professionals about C. neoformans Infection | Fungal Diseases | CDCInformation for Healthcare...
Cryptococcus neoformans can cause either no infection, latent infection, or symptomatic disease. Because C. neoformans enters ... Information for Healthcare Professionals about Cryptococcus neoformans Infection. ... C. neoformans can also disseminate to the central nervous system (CNS) and cause meningoencephalitis. Symptoms of a CNS ... C. neoformans infection is acquired through inhalation of basidiospores or desiccated yeast cells from the environment. The ...
Cryptococcus neoformans infecção | Examedesangue.com
IMSEAR at SEARO: Cryptococcus neoformans in Siriraj Hospital 1994-1995.
Cryptococcus neoformans in Siriraj Hospital 1994-1995.. 作者: Imwidthaya, Pankorn. Sethakorn, Chantima. Chaiprasert, Angkana. ... Cryptococcus neoformans in Siriraj Hospital 1994-1995. Siriraj Medical Journal, 1997 Dec; 49(12): 1145-1052. ... C.neoformans is susceptible to various antifungal agents, namely amphotericin B, flucytosine, fluconazole and itraconazole, in ... Patients suffered from only one serotype of C.neoformans. The fingerprint pattern was stable under the stress of various drug ...
Editorialresponse: Clinical and host differences between infections with the two varieties of cryptococcus neoformans
Cryptococcus Neoformans - Habitat, Epidemiology, Treatment + More
Learn everything there is to know about Cryptococcus Neoformans - Habitat, Morphology, Epidemiology, Virulence Factors, ... neoformans and C. neoformans var. grubii. C. neoformans var. neoformans grows as bright red colonies, turning the medium a ... isolates of neoformans can be divided into two varieties, C. neoformans var. neoformans and C. neoformans var. gattii, ... neoformans is an encapsulated, environmental yeast.. *Cryptococcus neoformans is a round or oval yeast measuring 4-6 µm in ...
Cryptococcus neoformans - Infectious Dis. - Medbullets Step 2/3
A 62-year-old man presents to the emergency room with headaches, fevers, and generalized malaise for the past week. His latest visit to the HIV clinic reveals a CD4+ cell count of 50. He has had issues with insurance and has not been on his HIV medications. A lumbar puncture is performed and yeast with clear halos is seen with India ink stain. He is started immediately on the appropriate medications. ...
Construction of pro1 Reconstituted Strain of Cryptococcus neoformans
A yeast under cover: The capsule of Cryptococcus neoformans<...
Bose, I, Reese, AJ, Ory, JJ, Janbon, G & Doering, TL 2003, A yeast under cover: The capsule of Cryptococcus neoformans, ... A yeast under cover: The capsule of Cryptococcus neoformans. Eukaryotic Cell. 2003 Aug;2(4):655-663. doi: 10.1128/EC.2.4.655- ... A yeast under cover: The capsule of Cryptococcus neoformans. Indrani Bose, Amy J. Reese, Jeramia J. Ory, Guilhem Janbon, Tamara ... A yeast under cover : The capsule of Cryptococcus neoformans. In: Eukaryotic Cell. 2003 ; Vol. 2, No. 4. pp. 655-663. ...
Pesq. Antigénio Cryptococcus neoformans (soro) - Análise Clínicas - Germano de Sousa - Análises
Domain assignment for CNAG 04235T0 from Cryptococcus neoformans var. grubii H99
04235T0 from Cryptococcus neoformans var. grubii H99 . Plus protein sequence and external database links. ... Domain assignment for CNAG_04235T0 from Cryptococcus neoformans var. grubii H99 Domain architecture ... CNAG_04235 , Cryptococcus neoformans grubii H99 conserved hypothetical protein (151 aa). Sequence. ...
Meningitis: Practice Essentials, Background, Pathophysiology
CryptococcosisGrubiiYeastSerotypeFungusPathogen Cryptococcus neoformansHuman fungal pathogenFungiInfectionCandidaPathogenicMeningitisInfectionsAspergillusHistoplasmaDroppingsFilobasidiellaIsolatesOpportunisticVarietiesEpidemiologyIsolationVirulenceSerotypesAntifungal agentsClinicalDiagnosisPulmonaryOccurrenceMelaninSaccharomycesDetectionAsymptomaticMiceEucalyptusLung
Cryptococcosis18
- Mortality, after intravenous C. neoformans -induced cryptococcosis, in young (8-week-old) and older (24-week-old) FcγRIIb−/− mice, was higher than in age-matched wild-types. (nature.com)
- Because cryptococcosis is an important invasive fungal infection in SLE, we examined the immune responses of FcγRIIb−/− mice to Cryptococcus neoformans, in vivo and in vitro . (nature.com)
- Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven pulmonary cryptococcosis due to capsule-intact Cr. (unboundmedicine.com)
- We compared the clinical manifestations, laboratory and radiologic findings, and outcomes of eight patients with proven pulmonary cryptococcosis (PC) caused by capsule-deficient Cryptococcus neoformans with those of six patients with PC caused by capsule-intact Cr. (unboundmedicine.com)
- Throughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the northern and northeastern states. (fiocruz.br)
- Cryptococcosis is a fungal disease caused by the infiltration of the Cryptococcus neoformans fungus. (authentique-esthetique.fr)
- A species of the fungus cryptococcus, the causative agent of cryptococcosis. (authentique-esthetique.fr)
- Two species, Cryptococcus neoformans and C. People can become infected with C. The most common risk for cryptococcosis caused by C. CRYPTOCOCCUS NEOFORMANS. (authentique-esthetique.fr)
- Its teleomorph is Filobasidiella neoformans, a filamentous fungus belonging to the class cryptococcosis - fungal meningitis - Cryptococcus neoformans - yeast - Filobasidiella neoforman. (authentique-esthetique.fr)
- Cryptococcus neoformans is the fungal caustic agent of Cryptococcosis. (wellnessadvantage.com)
- In our body, the infectious dis-ease, Cryptococcosis (Torulosis) , is a type of fungal infection , indicative to a specific set of signs, symptoms or other health indicators, associated with a health challenge with a fungus of the species Cryptococcus neoformans . (wellnessadvantage.com)
- Micrograph of cryptococcosis showing the characteristically thick capsule of cryptococcus. (wikipedia.org)
- Cryptococcosis due to Cryptococcus neoformans and Cryptococcus gattii varies with geographic region, populations affected, disease manifestations, and severity of infection , which impact treatment . (bvsalud.org)
- Cryptococcosis is infection with the fungi Cryptococcus neoformans or Cryptococcus gattii . (medlineplus.gov)
- Perfect JR. Cryptococcosis ( Cryptococcus neoformans and Cryptococcus gattii ). (medlineplus.gov)
- Cryptococcus neoformans is a causative agent of the fungal infection cryptococcosis. (cdc.gov)
- No koalas from which C. neoformans was persistently isolated showed clinical signs of cryptococcosis and all except one had a negative latex cryptococcal antigen test, therefore the nasal cavity was presumed to be colonized by, rather than infected with, C. neoformans. (edu.au)
- The main infectious agent responsible for cryptococcosis is the fungus Cryptococcus neoformans , an encapsulated yeast mainly spread by airborne transmission that is present in soil and organic debris. (pasteur.fr)
Grubii3
Yeast14
- Cryptococcus neoformans is an encapsulated yeast ubiquitous in nature which, when it infects humans, typically causes pulmonary disease and occasionally meningitis [1]. (who.int)
- The genome of the basidiomycete pathogenic yeast Cryptococcus neoformans carries two UDP-glucose epimerase genes (UGE1 and UGE2). (pasteur.fr)
- Cryptococcus neoformans , an opportunistic yeast pathogen, relies on a complex network of stress response pathways that allow for proliferation in the host. (clemson.edu)
- Cryptococcus neoformans is an encapsulated yeast and an obligate aerobe that can live in both plants and animals. (ensembl.org)
- Cryptococcus neoformans is a basidiomycetous yeast capable of causing fatal meningoencephalitis in immunocompromised individuals. (authentique-esthetique.fr)
- neoformans is a spherical yeast, 4-6 µm in diameter, that produces a capsule containing glucoronoxylomannan (GXM), extending the overall. (authentique-esthetique.fr)
- Depending on the virulence of the yeast strain and the immune status of the host, Cryptococcus neoformans can cause either no infection, latent infection, or symptomatic disease. (cdc.gov)
- C. neoformans infection is acquired through inhalation of basidiospores or desiccated yeast cells from the environment. (cdc.gov)
- neoformans is an encapsulated, environmental yeast. (microbiologyinfo.com)
- Cryptococcus neoformans is a round or oval yeast measuring 4-6 µm in diameter, surrounded by a capsule that can be up to 30 µm thick. (microbiologyinfo.com)
- Persisting Cryptococcus yeast species Vishniacozyma victoriae and Cryptococcus neoformans elicit unique airway inflammation in mice following repeated exposure. (cdc.gov)
- India ink stain to reveal the polysaccharide capsule on yeast cells of the AIDS-associated pathogen Cryptococcus neoformans. (ubc.ca)
- The occurrence of the primary pathogenic addition, Streptococcus pneumoniae yeast Cryptococcus gattii in Europe. (cdc.gov)
- If encapsulated yeast are observed there is a high correlation with the presence of Cryptococcus neoformans, viable or non-viable forms. (fairview.org)
Serotype5
- The larger number of genotype VNI iso- mans , serotype D, C. neoformans var. (cdc.gov)
- neoformans (serotype D) and C. neoformans var. (who.int)
- In the USA, the most prevalent serotype of the fungus, Cryptococcus neoformans, was serotype A. This serotype constituted 203 of 272 isolates from infections and 85 of 89 isolates from the environment. (elsevier.com)
- The C. neoformans species complex includes two separate species, C. neoformans (serotype A) represented by genotypes VNI, VNII, and VNB and C. deneoformans (serotype D) represented by genotype VNIV. (biomedcentral.com)
- Patients suffered from only one serotype of C.neoformans. (who.int)
Fungus8
- Its teleomorph is Filobasidiella neoformans , a filamentous fungus belonging to the class Tremellomycetes. (ensembl.org)
- Cryptococcus neoformans is a ubiquitous environmental encapsulated fungus. (microbiologyinfo.com)
- In nature, Cryptococcus neoformans is a species of the fungus of the Cryptococcus genus , in the Cryptococcaceae family of the Tremellales order in the Tremellomycetes class of the Agaricomycotina subphylum in the Basidiomycota phylum (basidiomycetes) within the Fungi kingdom (fungus) . (wellnessadvantage.com)
- Diagnosis is by isolating Cryptococcus from a sample of affected tissue or direct observation of the fungus by using staining of body fluids. (wikipedia.org)
- Cryptococcus is the most common fungus that causes serious infection worldwide. (medlineplus.gov)
- 1,2 People can become infected with C. neoformans after breathing in the microscopic fungus, although most people exposed to the fungus never get sick from it. (cdc.gov)
- The fungus Cryptococcus neoformans is present in the environment, and contamination generally occurs by inhalation . (pasteur.fr)
- A species of the fungus CRYPTOCOCCUS . (bvsalud.org)
Pathogen Cryptococcus neoformans3
- Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. (duke.edu)
- Here we show that another process is involved in generating genotypes of sexual progeny from a hybrid cross between two divergent lineages of the human fungal pathogen Cryptococcus neoformans. (singerinstruments.com)
- Mechanisms of infection by the human fungal pathogen Cryptococcus neoformans . (cdc.gov)
Human fungal pathogen1
- The human fungal pathogen Cryptococcus is able to rapidly and effectively adjust to variable conditions, favoring its survival in the environment and in the infected host [ 11 ]. (biomedcentral.com)
Fungi4
- neoformans after breathing in the by HC Eisenman · 2011 · Cited by 36 - Cryptococcus neoformans is unusual among melanotic fungi in that it requires an exogenous supply of precursor to synthesize melanin. (authentique-esthetique.fr)
- It is caused by the fungi Cryptococcus neoformans or less commonly Cryptococcus gattii , and is acquired by breathing in the spores from the air. (wikipedia.org)
- C neoformans and C gattii are the fungi that cause this disease. (medlineplus.gov)
- Our results show that melanin in C. neoformans cells is susceptible to some damage by hydroxyl radical formed in lethal radioactive aqueous environments and serves a protective role in melanized fungi that involves sacrificial breakdown. (elsevier.com)
Infection9
- Because C. neoformans enters the body through the respiratory route, infection can present as pneumonia-like illness, with symptoms such as cough, fever, chest pain, and weight loss. (cdc.gov)
- Males are more likely to develop the infection and a 2020 study showed that the sex bias may be due to a growth hormone, produced by C. neoformans called gibberellic acid (GA) that is upregulated by testosterone. (wikipedia.org)
- We compared underlying diseases , clinical manifestations, treatment , and outcomes in patients with C. gattii or C. neoformans infection . (bvsalud.org)
- Infection with C neoformans is seen worldwide. (medlineplus.gov)
- C neoformans is the most common life-threatening cause of fungal infection in people with HIV/AIDS. (medlineplus.gov)
- 9 Little is known about the specific activities that may increase risk of C. neoformans infection, although working near bird droppings may increase exposure. (cdc.gov)
- The Molecular Mycology Unit also investigates factors involved in the virulence and dormancy of Cryptococcus neoformans and conducts research on the pathophysiology of infection and the development of new tests. (pasteur.fr)
- Cryptococcus neoformans infection as a cause of severe hyperammonaemia and encephalopathy. (nih.gov)
- Routine siliqua (carob) trees as natural habitat and laboratory test results were within source of infection by Cryptococcus gattii by Mycobacterium normal limits. (cdc.gov)
Candida2
- Cryptococcus neoformans and Candida albicans, 4. (authentique-esthetique.fr)
- Though a wide range of organisms and diseases is considered, the most extensive information centers on common mycoses associated with invasive fungal infections, including Candida albicans, Cryptococcus neoformans, and Aspergillus spp. (who.int)
Pathogenic2
- This study provides the first insights into the Egyptian horse ecology of Cryptococcus species and highlights the role of horses as asymptomatic carriers in disseminating the potentially pathogenic Cryptococcus spp. (biomedcentral.com)
- Cryptococcus neoformans is an opportunistic fungal pathogen whose pathogenic lifestyle is linked to its ability to cope with fluctuating levels of copper (Cu), an essential metal involved in multiple virulence mechanisms, within distinct host niches. (jbc.org)
Meningitis6
- In South Africa, Cryptococcus neoformans is the most common cause of adult meningitis. (authentique-esthetique.fr)
- People can become infected with C. . Cryptococcus neoformans es una levadura oportunista que produce criptococosis pulmonar, neumonía aguda atípica y meningitis crónica. (authentique-esthetique.fr)
- C. neoformans meningitis may lead to permanent neurologic damage. (cdc.gov)
- During lethal cryptococcal meningitis in the brain, C. neoformans senses a Cu-deficient environment and is highly dependent on its ability to scavenge trace levels of Cu from its host and adapt to Cu scarcity to successfully colonize this niche. (jbc.org)
- In humans, C. neoformans chiefly infects the skin, lungs, and central nervous system (causing meningitis ). (wikipedia.org)
- Cryptococcus is a ubiquitous fungal pathogen that causes primarily meningitis and pneumonia. (cdc.gov)
Infections12
- It is caused by the Cryptococcus neoformans species complex and the Cryptococcus gattii species complex and is usually associated with pulmonary and systemic infections in humans and animals [ 1 , 2 ]. (biomedcentral.com)
- . neoformans has a more restricted distribution with infections being more prevalent in Europe, including France, Italy and Denmark, where it accounts for 30% of isolates. (microbiologyinfo.com)
- neoformans is found worldwide, is associated with avian excreta (particularly that of pigeons), and causes the vast majority of human infections. (microbiologyinfo.com)
- neoformans infections are more strongly correlated with older patients, the skin, and the use of corticosteroids. (microbiologyinfo.com)
- grubi i has a worldwide distribution, causing 95% of all C. neoformans infections. (microbiologyinfo.com)
- [9] Pigeon breeders (or fanciers) are known to have a high incidence of cryptococcal infections including PCC due to Cryptococcus' association with pigeon droppings. (wikipedia.org)
- MSG07: An International Cohort Study Comparing Epidemiology and Outcomes of Patients With Cryptococcus neoformans or Cryptococcus gattii Infections. (bvsalud.org)
- blood infections were more common in C. neoformans-infected patients (Pâ ≤â .0001 for both). (bvsalud.org)
- C. neoformans infections are rare in otherwise healthy people. (cdc.gov)
- and Cryptococcus neoformans , that cause infections. (iso.org)
- C. neoformans has a clear predilection for causing disease in persons in whom the immune system is impaired, and today an overwhelming proportion of C. neoformans infections occur in immunocompromised persons. (cdc.gov)
- Early data from endemic areas suggested that C. gattii differed not only in epidemiology and clinical presentation from C. neoformans , but might also have different susceptibilities to antifungal agents and require more aggressive and lengthier antifungal therapy than C. neoformans infections. (cdc.gov)
Aspergillus2
- The repertoires of Cryptococcus neoformans, Aspergillus fumigatus , and Aspergillus nidulans were found to exhibit the highest orthology to the human repertoire, and Saccharomyces cerevisiae one of the lowest. (biomedcentral.com)
- 3), C. neoformans (2), Aspergillus sp. (bvsalud.org)
Histoplasma1
- In addition to Histoplasma , Cryptococcus neoformans may also be a health risk for workers who disturb accumulations of bird or bat droppings. (cdc.gov)
Droppings1
- Three hundred and sixty five samples of avian droppings, collected from parks and zoo, were investigated for the occurrence of Cryptococcus neoformans in Korea. (koreamed.org)
Filobasidiella2
- Su telemorfo es la Filobasidiella neoformans. (bvsalud.org)
- Its teleomorph is Filobasidiella neoformans. (bvsalud.org)
Isolates5
- isolates recovered from the nasal passages of horses proved that C. gattii (B), C. neoformans , and two hybrids between C. neoformans (A) and C. gattii (B) were identified. (biomedcentral.com)
- Meanwhile, in case of soil samples, the isolates were identified as C. gattii (B). The human isolates were serotyped as C. gattii in two isolates and C. neoformans in only one isolate. (biomedcentral.com)
- Molecular detection of some virulence genes (LAC1), (CAP59), and (PLB1) were identified in both C. gattii and C. neoformans isolates. (biomedcentral.com)
- Isolates of neoformans can also be divided into five serotypes, termed A, B, C, D and AD (both A and D determinants present) on the basis of antigenic differences between their capsular polysaccharides. (microbiologyinfo.com)
- All isolates belonged to C. neoformans var. (koreamed.org)
Opportunistic1
- BACKGROUND: Cryptococcus neoformans (CN) is an opportunistic pathogen that can cause fatal meningoencephalitis in patients with immune deficiency. (elsevier.com)
Varieties2
Epidemiology2
- To this have been used to study the epidemiology of C. neoformans . (cdc.gov)
- Our results provide new information on the molecular epidemiology of C. neoformans and C. gattii in Brazilian endemic areas. (fiocruz.br)
Isolation2
- Isolation of Cryptococcus neoformans var. (koreamed.org)
- Patient 3, a 70-year-old man technique for isolation of Cryptococcus in 2006 from a patient with neoformans from decayed wood in tree with tongue cancer, was admitted to trunk hollows. (cdc.gov)
Virulence2
- Here, we show that UGE2 is necessary for C. neoformans cells to utilize galactose as a carbon source at 30 degrees C but is not required for virulence. (pasteur.fr)
- The Cryptococcus neoformans and their virulence for mice. (authentique-esthetique.fr)
Serotypes2
- gattii , serotypes B and lates agrees with the fact that C. neoformans var. (cdc.gov)
- Howard, Dexter H. / Epidemiologic differences among serotypes of Cryptococcus neoformans . (elsevier.com)
Antifungal agents1
- C.neoformans is susceptible to various antifungal agents, namely amphotericin B, flucytosine, fluconazole and itraconazole, in the therapeutic range. (who.int)
Clinical2
- We performed multi locus sequence typing and fluconazole susceptibility testing of clinical C. neoformans var. (authentique-esthetique.fr)
- Result of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), performed on a clinical specimen, specific for Cryptococcus gattii . (cdc.gov)
Diagnosis1
- C. Laboratory Diagnosis of Cryptococcus neoformans. (authentique-esthetique.fr)
Pulmonary3
- neoformans, and pulmonary involvement may be minimal if dissemination occurs quickly. (authentique-esthetique.fr)
- Objective: This study aimed to compare the immunological impact of repeated pulmonary exposure to Cryptococcus yeasts. (cdc.gov)
- Discussion: C. neoformans remained in the lungs and exacerbated the pulmonary immune responses as expected following repeated exposure. (cdc.gov)
Occurrence2
- The current study was carried out to investigate the occurrence of Cryptococcus spp. (biomedcentral.com)
- The overall occurrence of Cryptococcus spp. (biomedcentral.com)
Melanin2
- neoformans produces melanin pigments that play a protective role in both natural and physiological. (authentique-esthetique.fr)
- Cryptococcus neoformans (C. neoformans), which uses L-3,4-dihydroxyphenylalanine (L-DOPA) to produce melanin, was used here to investigate how gamma radiation under aqueous aerobic conditions affects the properties of melanin, with the aim of gaining insight into its radioprotective role. (elsevier.com)
Saccharomyces1
- Also, the repertoire of Cryptococcus neoformans may represent a better model fungal system within which to study the functions of the PPIases as its genome size and genetic tractability are equal to those of Saccharomyces cerevisiae , whilst its repertoires exhibits greater orthology to that of humans. (biomedcentral.com)
Detection1
- Detection of Cryptococcus neoformans antigen by latex agglutination. (tamu.edu)
Asymptomatic3
- After C. neoformans administration, FcγRIIb−/− mice demonstrated higher mortality than the age-matched wild-type control mice in both the asymptomatic and symptomatic lupus groups ( Fig. 1A-D ). In the young mouse group, all of the FcγRIIb−/− mice, but only 57% of the wild-type mice, died or became moribund within 90 days of challenge ( Fig. 1A ). (nature.com)
- Asymptomatic carriage of Cryptococcus neoformans in the nasal cavity of the koala (Phascolarctos cinereus). (edu.au)
- Dive into the research topics of 'Asymptomatic carriage of Cryptococcus neoformans in the nasal cavity of the koala (Phascolarctos cinereus). (edu.au)
Mice3
- When administered to wild-type mice, FcγRIIb−/− macrophages with phagocytosed Cryptococcus resulted in higher fungal burdens than FcγRIIb+/+ macrophages with phagocytosed Cryptococcus . (nature.com)
- These results support, at least in part, a model whereby, in FcγRIIb−/− mice, enhanced C. neoformans transmigration occurs through infected macrophages. (nature.com)
- Methods: Mice were repeatedly exposed to an immunogenic dose of C. neoformans or V. victoriae via oropharyngeal aspiration. (cdc.gov)
Eucalyptus2
- Furthermore, it is a classical result of interactions between the host-pathogen and environmental sources that comprise soil contaminated with avian (most often pigeon) guano ( C. neoformans ) or soil debris and decaying trees like eucalyptus trees ( C. gattii ) [ 9 ]. (biomedcentral.com)
- Cryptococcus gattii is found in trees such as eucalyptus and is also spread by inhalation. (pasteur.fr)
Lung2
- Repeated C. neoformans exposure initiated myeloid and lymphoid cellular infiltration into the lung that worsened over time, as well as an IL-4 and IL-5 response compared to PBS-exposed controls. (cdc.gov)
- Same-sex mating and the origin of indicated new nodular lung lesions the Vancouver Island Cryptococcus gat- abscess after a fat injection ( 4 ). (cdc.gov)