AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
CryptococcosisCryptococcus neoformansCryptococcusLung Diseases, FungalCryptococcus gattiiMeningitis, CryptococcalAntifungal AgentsFluconazoleAntigens, FungalAmphotericin BAntibodies, FungalDermatomycosesAIDS-Related Opportunistic InfectionsFlucytosineImmunocompetenceTransplantsCellulitisImmunocompromised HostMeningoencephalitisPolysaccharidesSuloctidilCerebrospinal FluidOrgan TransplantationLung Diseases, ParasiticHIV SeronegativityMycosesBone Diseases, InfectiousMycological Typing TechniquesAdrenal Gland DiseasesAspergillosisFungal VaccinesCentral Nervous System DiseasesCentral Nervous System Fungal InfectionsFatal OutcomeMeningitisFungemiaVirulenceOpportunistic InfectionsAbortion, SepticTriazolesLatex Fixation TestsEncyclopedias as TopicAdrenal Cortex Hormones
Cryptococcosis
Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.
Cryptococcus neoformans
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
Cryptococcus
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
Lung Diseases, Fungal
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Cryptococcus gattii
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella bacillispora.
Meningitis, Cryptococcal
Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
Antifungal Agents
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Fluconazole
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
Antigens, Fungal
Substances of fungal origin that have antigenic activity.
Amphotericin B
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
Antibodies, Fungal
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Dermatomycoses
Superficial infections of the skin or its appendages by any of various fungi.
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Flucytosine
A fluorinated cytosine analog that is used as an antifungal agent.
Immunocompetence
The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.
Transplants
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Cellulitis
An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.
Immunocompromised Host
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Meningoencephalitis
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Polysaccharides
Suloctidil
A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)
Cerebrospinal Fluid
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
Organ Transplantation
Transference of an organ between individuals of the same species or between individuals of different species.
Lung Diseases, Parasitic
Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).
HIV Seronegativity
Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.
Mycoses
Bone Diseases, Infectious
Bone diseases caused by pathogenic microorganisms.
Mycological Typing Techniques
Procedures for identifying types and strains of fungi.
Adrenal Gland Diseases
Pathological processes of the ADRENAL GLANDS.
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.
Fungal Vaccines
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
Central Nervous System Diseases
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Central Nervous System Fungal Infections
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Fatal Outcome
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Meningitis
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Fungemia
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Virulence
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Opportunistic Infections
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Abortion, Septic
Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.
Triazoles
Latex Fixation Tests
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Adrenal Cortex Hormones

In-vivo therapeutic efficacy in experimental murine mycoses of a new formulation of deoxycholate-amphotericin B obtained by mild heating. (1/1120)

Heat-induced 'superaggregation' of deoxycholate-amphotericin B (AmB-DOC, Fungizone) was shown previously to reduce the in-vitro toxicity of this antifungal agent. We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungizone, Bristol Myers Squibb, Paris, France) for 20 min at 70 degrees C, in the treatment of murine infections. An improvement of antifungal activity was obtained with heated AmB-DOC formulations due to a lower toxicity which allowed the administration of higher drug doses than those achievable with the commercial preparation. Single intravenous injections of heated AmB-DOC solutions were demonstrated to be two-fold less toxic than unheated ones to healthy mice. For mice infected with Candida albicans, the maximum tolerated dose was higher with heated than with unheated AmB-DOC solutions. In the model of murine candidiasis, following a single dose of heated AmB-DOC 0.5 mg/kg, 85% of mice survived for 3 weeks, whereas at this dose the immediate toxicity of the standard formulation in infected mice restricted the therapeutic efficacy to 25% survival. Both formulations were equally effective in increasing the survival time for murine cryptococcal pneumonia and meningoencephalitis. Injection of heated AmB-DOC solutions at a dose two-fold higher than the maximal tolerated dose observed with the unheated preparation (1.2 mg/kg) increased the survival time by a factor of 1.4 in cryptococcal meningoencephalitis. These results indicate that mild heat treatment of AmB-DOC solutions could provide a simple and economical method to improve the therapeutic index of this antifungal agent by reducing its toxicity on mammalian cells.  (+info)

A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. National Institute of Allergy and Infectious Diseases Mycoses Study Group. (2/1120)

This study was designed to compare the effectiveness of fluconazole vs. itraconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. HIV-infected patients who had been successfully treated (achieved negative culture of CSF) for a first episode of cryptococcal meningitis were randomized to receive fluconazole or itraconazole, both at 200 mg/d, for 12 months. The study was stopped prematurely on the recommendation of an independent Data Safety and Monitoring Board. At the time, 13 (23%) of 57 itraconazole recipients had experienced culture-positive relapse, compared with 2 relapses (4%) noted among 51 fluconazole recipients (P = .006). The factor best associated with relapse was the patient having not received flucytosine during the initial 2 weeks of primary treatment for cryptococcal disease (relative risk = 5.88; 95% confidence interval, 1.27-27.14; P = .04). Fluconazole remains the treatment of choice for maintenance therapy for AIDS-associated cryptococcal disease. Flucytosine may contribute to the prevention of relapse if used during the first 2 weeks of primary therapy.  (+info)

Cryptococcosis in children with AIDS. (3/1120)

We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/microL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of approximately 1% was estimated.  (+info)

Variants of a Cryptococcus neoformans strain elicit different inflammatory responses in mice. (4/1120)

The virulence of Cryptococcus neoformans isolates with high and low extracellular proteolytic activity was investigated in mice. No consistent relationship between proteolytic activity and virulence was observed, but isolates derived from one strain were shown to elicit different inflammatory responses.  (+info)

Serotyping of Cryptococcus neoformans isolates from clinical and environmental sources in Spain. (5/1120)

We determined biovars and serotypes of 154 isolates of Cryptococcus neoformans from clinical and environmental sources from different areas of Spain. All clinical isolates belonged to C. neoformans var. neoformans. Serotypes showed an irregular distribution. C. neoformans var. gattii serotype B was isolated from necropsy specimens from goats with pulmonary disease.  (+info)

Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis. (6/1120)

Cryptococcus neoformans causes infection in individuals with defective T cell function, such as AIDS, as well as without underlying disease. It has been suggested that humoral as well as cellular immunity might play an important role in the immune response to C. neoformans infection. We have recently shown, using immunoblotting, that the 70-kD hsp family of C. neoformans was the major target molecule of the humoral response in murine pulmonary cryptococcosis. In this study we also used immunoblotting to define the antibody responses in the sera of 24 patients with pulmonary cryptococcosis: 21 proven and three suspected diagnoses. Anti-C. neoformans hsp70 antibody was detected in 16 of 24 (66.7%) patients with pulmonary cryptococcosis. Fourteen of 17 (82.3%) patients with high antigen titres (> or = 1:8) and two of seven (28.6%) patients with low titres (< or = 1:4) had detectable levels of anti-hsp70 antibody. Sera from patients positive for anti-hsp70 antibody showed high titres in the Eiken latex agglutination test for the detection of serum cryptococcal antigen. Our results indicate that the 70-kD hsp family from C. neoformans appears to be a major target molecule of the humoral response, not only in murine pulmonary cryptococcosis, but also in human patients with pulmonary cryptococcosis.  (+info)

Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. (7/1120)

Activated T lymphocytes play a crucial role in orchestrating cellular infiltration during a cell-mediated immune (CMI) reaction. TCA3, a C-C chemokine, is produced by Ag-activated T cells and is chemotactic for neutrophils and macrophages, two cell types in a murine CMI reaction. Using a gelatin sponge model for delayed-type hypersensitivity (DTH), we show that TCA3 is a component of the expression phase of an anticryptococcal CMI response in mice. TCA3 mRNA levels are augmented in anticryptococcal DTH reactions at the same time peak influxes of neutrophils and lymphocytes are observed. Neutralization of TCA3 in immunized mice results in reduced numbers of neutrophils and lymphocytes at DTH reaction sites. However, when rTCA3 is injected into sponges in naive mice, only neutrophils are attracted into the sponges, indicating TCA3 is chemotactic for neutrophils, but not lymphocytes. We show that TCA3 is indirectly attracting lymphocytes into DTH-reactive sponges by affecting at least one other chemokine that is chemotactic for lymphocytes. Of the two lymphocyte-attracting chemokines assessed, monocyte-chemotactic protein-1 and macrophage-inflammatory protein-1alpha (MIP-1alpha), only MIP-1alpha was reduced when TCA3 was neutralized, indicating that TCA3 affects the levels of MIP-1alpha, which attracts lymphocytes into the sponges. TCA3 also plays a role in protection against Cryptococcus neoformans in the lungs and brains of infected mice, as evidenced by the fact that neutralization of TCA3 results in increased C. neoformans CFU in those two organs.  (+info)

Antibody response to Cryptococcus neoformans proteins in rodents and humans. (8/1120)

The prevalence and specificity of serum antibodies to Cryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcosis, in matched samples from HIV-positive individuals who did not develop cryptococcosis, and in HIV-negative individuals. Rodents had little or no serum antibody reactive with C. neoformans proteins prior to infection. The intensity and specificity of the rodent antibody response were dependent on the species, the mouse strain, and the viability of the inoculum. All humans had serum antibodies reactive with C. neoformans proteins regardless of the potential exposure, the HIV infection status, or the subsequent development of cryptococcosis. Our results indicate (i) a high prevalence of antibodies reactive with C. neoformans proteins in the sera of rodents after cryptococcal infection and in humans with or without HIV infection; (ii) qualitative and quantitative differences in the antibody profiles of HIV-positive individuals; and (iii) similarities and differences between humans, mice, and rats with respect to the specificity of the antibodies reactive with C. neoformans proteins. The results are consistent with the view that C. neoformans infections are common in human populations, and the results have implications for the development of vaccination strategies against cryptococcosis.  (+info)

Cryptococcosis: Its Prevalence and Clinical Presentation among Hiv Positive and Negative Patients in Rims, Manipur - Semantic...Cryptococcosis: Its Prevalence and Clinical Presentation among Hiv Positive and Negative Patients in Rims, Manipur - Semantic...
Cryptococcus neoformans, the causative fungal agent of cryptococcosis remain a common cause of infectious morbidity and mortality, especially among HIV-positive patients living in Sub-Saharan Africa and South-East Asia. This study was undertaken to evaluate the prevalence and clinical presentation of Cryptococcus infections among HIV positive and negative patients in RIMS, Manipur. Specimens like CSF, sputum, urine, blood, tissue biopsy or aspirates from clinically suspected cryptococcosis cases from RIMS hospital, were subjected to mycological examination. Out of the 48 patients enrolled for the study, Cryptococcus spp were isolated from 16 (33.33%) patients. Among these 16 cryptococcosis patients, majority of them presented with cryptococcal meningitis 13 (81.25%), while 1 (6.25%) patient each presented with cryptococcal lymphadenitis, disseminated cutaneous cryptococcosis and osseous cryptococcosis respectively. Also, of these 16 cryptococcosis patients, 14 (87.5%) were HIV positive. Among these HIV
https://www.semanticscholar.org/paper/Cryptococcosis-Its-Prevalence-and-Clinical-Present-Lungran-Devi/3aeeb6f86179583435e9f24049160bbb60432c79
Cryptococcosis - WikipediaCryptococcosis - Wikipedia
Cryptococcosis, also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused by one of two species; Cryptococcus neoformans and Cryptococcus gattii. These were all previously thought to be subspecies of C. neoformans but have now been identified as distinct species. Cryptococcosis is believed to be acquired by inhalation of the infectious propagule from the environment. Although the exact nature of the infectious propagule is unknown, the leading hypothesis is the basidiospore created through sexual or asexual reproduction. Cryptococcosis is a defining opportunistic infection for AIDS, and is the second-most-common AIDS-defining illness in Africa. Other conditions that pose an increased risk include certain lymphomas (e.g., Hodgkins lymphoma), sarcoidosis, liver cirrhosis, and patients on long-term corticosteroid therapy. Distribution is worldwide in soil. The prevalence of cryptococcosis has been increasing over the past 20 years for many reasons, including the ...
https://en.wikipedia.org/wiki/Cryptococcosis
Cryptococcosis Market: Competitive Dynamics & Global Outlook 2024 - BizPR.us | US Free Press Release and Distribution center
Cryptococcosis, also known as cryptococcal disease is a potentially fatal fungal disease. It is caused by inhalation of an encapsulated yeast called Cryptococcus neoformans. Cryptococcosis is believed to be acquired by inhalation of the infectious propagule from the environment. Although the exact nature of the infectious propagule is unknown, the leading hypothesis is the basidiospore created through sexual or asexual reproduction.. Cryptococcosis market: Types of infection. There are three identified Cryptococcus strains that causes disease worldwide namely Cryptococcus neoformans, Cryptococcus grubii and Cryptococcus gattii. Exposure via respiratory or the gastrointestinal tract are considered as the most common and opportunistic pathway for the organism entry in the host. Cryptococcus neoformans can be found worldwide in soil, birds, animals and humans. Whereas, alternative route of administration can be through transplant of infected tissue, surgical instrument or laboratory instruments. ...
http://bizpr.us/2017/01/25/cryptococcosis-market-competitive-dynamics-global-outlook-2024/
Clinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology LaboratoryClinical Utility of the Cryptococcal Antigen Lateral Flow Assay in a Diagnostic Mycology Laboratory
Background Cryptococcus neoformans causes life-threatening meningitis. A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting. Methods One hundred and six serum, 42 cerebrospinal fluid (CSF), and 20 urine samples from 92 patients with known or suspected cryptococcosis were tested by LA and LFA, and titres were compared. Results were correlated with laboratory-confirmed cryptococcosis. Serial samples were tested in nine treated patients. Results Twenty-five of 92 patients had confirmed cryptococcosis; all sera (n = 56) from these patients were positive by LFA (sensitivity 100%, 95% confidence interval (CI) 93.6-100%) compared with 51/56 positive by LA (sensitivity 91.1%, 95% CI 80.7-96.1%). Fifty sera from 67 patients without cryptococcosis tested negative in both assays. While LA yielded more false negative results (5/56
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049541
Global Cryptococcosis Treatment Market Analysis and GrowthGlobal Cryptococcosis Treatment Market Analysis and Growth
Global Cryptococcosis Treatment Market Analysis. Global Cryptococcosis Treatment Market Analysis According to Verified Market Research, the Global Cryptococcosis Treatment Market was valued at USD 4.2 Billion in 2018 and is projected to reach USD 6.6 Billion by 2026, growing at a CAGR of 4.4% from 2019 to 2026.The latest survey on Global Cryptococ
https://www.bccresearch.com/partners/verified-market-research/global-cryptococcosis-treatment-market-analysis.html
IL-12 and IFN-γ are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 Mice -...
Fingerprint Dive into the research topics of IL-12 and IFN-γ are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 Mice. Together they form a unique fingerprint. ...
https://utsouthwestern.pure.elsevier.com/en/publications/il-12-and-ifn-%CE%B3-are-required-for-initiating-the-protective-th1-re/fingerprints/
Global Cryptococcosis Market to Reach US$6.2 Billion by 2024 | TMRGlobal Cryptococcosis Market to Reach US$6.2 Billion by 2024 | TMR
The global cryptococcosis market was calculated to reach US$4.31 bn by the end of 2016, and is projected to reach US$6.2 bn by the end of 2024, cryptococcosis market is after expanding at a CAGR of 4.8% from 2016 to 2024.
http://www.sbwire.com/press-releases/cryptococcosis-market/release-1197130.htm
Cryptococcosis: An Emerging Airborne Mycosis of Global Concern | OMICS InternationalCryptococcosis: An Emerging Airborne Mycosis of Global Concern | OMICS International
Cryptococcosis, an emerging highly infectious respiratory mycosis, is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, which exist as saprobe in the envi..
https://www.omicsonline.org/open-access/cryptococcosis-an-emerging-airborne-mycosis-of-global-concern-2167-7719-1000127.php?aid=80412
Cryptococcosis
Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkins disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms ...
http://www.diseaseinfosearch.org/result/2024
Canine Cryptococcosis - A Fungal Infection Inducing Sneezing in DogsCanine Cryptococcosis - A Fungal Infection Inducing Sneezing in Dogs
Cryptococcosis is a yeast-like fungal infection. Symptoms include weight loss, lethargy, and fight-like wounds on the nose and skin. Treatment includes oral antifungal medication and possibly surgery, depending on severity of wounds.
http://www.pethealthnetwork.com/node/112
Feline CryptococcosisFeline Cryptococcosis
Cryptococcosis is a yeast-like fungal infection. Symptoms include weight loss, lethargy, fight-like wounds on the nose and skin. Treatment includes oral antifungal medication and possibly surgery, depending on severity of wounds.
http://pethealthnetwork.com/cat-health/cat-diseases-conditions-a-z/cryptococcosis-cats
Cryptococcosis in CatsCryptococcosis in Cats
Cryptococcosis is the most common systemic fungal disease of domestic cats worldwide. It is caused by a fungus belonging to the genus Cryptococcous.
http://catexpert.blogspot.fr/2014/07/cryptococcosis-in-cats.html
Cryptococcosis Treatment Market to Soar at steady CAGR up to 2026
The latest report on Cryptococcosis Treatment market as Added by Market Study Report, LLC, offers comprehensive details on industry size, regional spectrum and revenue estimates of the business. In addition, the report stresses on major challenges as well as the latest growth strategies implemented by significant players of the industry.
http://news.decresearch.com/cryptococcosis-treatment-market-to-soar-at-steady-cagr-up-to-2026
Pulmonary Manifestations of Cryptococcosis in Patients with AIDS: CT FeaturesPulmonary Manifestations of Cryptococcosis in Patients with AIDS: CT Features
SummaryThe computed tomographic (CT) scans and chest radiographs of 10 patients with AIDS and proven pulmonary cryptococcal infections were reviewed. In seven patients (70%), CT demonstrated pulmonary opacities that ranged in appearance from a perihilar interstitial pattern to an area of dense alveo
https://insights.ovid.com/thoracic-imaging/jthim/1994/21/000/pulmonary-manifestations-cryptococcosis-patients/4/00005382
Cryptococcosis Medication: Antifungal agentsCryptococcosis Medication: Antifungal agents
Cryptococcus neoformans is an encapsulated yeast. In 1894, Busse, a pathologist, first described the yeast in a paper he presented to the Greifswald Medical Society.
https://emedicine.medscape.com/article/215354-medication
2018 ICD-10-CM Codes B45*: Cryptococcosis2018 ICD-10-CM Codes B45*: Cryptococcosis
An acute or chronic, localized or disseminated infection by cryptococcus neoformans. Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs ...
http://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B45-
Conference Notes 7-23-2013 - ACMC EMConference Notes 7-23-2013 - ACMC EM
Jones FX Fracture line extends to 4-5 intermetatarsal space. Cryptococcosis is the most common fungal disease in HIV -infected persons, and it is the AIDS-defining illness for 60-70% of HIV-infected patients.. In addition to invading the lung and CNS, cryptococci also invade the skin, bone, and genitourinary tract, but meninges appear to be the preferred site.. Cryptococcal disease usually develops only when CD4+ lymphocyte counts fall below 100 cells/microL.. Disease onset is usually insidious; time from symptom onset to diagnosis is, on average, 30 days or more. The delay also may be due to the waxing-and-waning course and the nonspecificity of symptoms. Headache, fever, malaise, nonspecific mental status sx, uncommonly CN palsies, seizures, focal neuro sx. Also uncommon to see meningismus (no immune system).. CSF analysis may yield normal (ie, reference) results in 25% of patients and may be minimally abnormal in as many as 50%; therefore, identifying the organism via India Ink and serology ...
http://www.christem.com/acmcem-conf-notes/2013/7/24/conference-notes-7-23-2013.html
SERUM PROTEIN ENHANCEMENT OF ANTIBIOTIC THERAPY IN CRYPTOCOCCOSIS. - PubMed - NCBISERUM PROTEIN ENHANCEMENT OF ANTIBIOTIC THERAPY IN CRYPTOCOCCOSIS. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/14217937?dopt=Abstract
New Insights into HIV/AIDS-Associated CryptococcosisNew Insights into HIV/AIDS-Associated Cryptococcosis
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
https://www.hindawi.com/journals/isrn/2013/471363/ref/
CryptococcosisCryptococcosis
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
http://www.psychiatryadvisor.com/pediatrics/cryptococcosis/article/623622/
Cryptococcosis | Quick Answers: Pharmacy | AccessPharmacy | McGraw Hill MedicalCryptococcosis | Quick Answers: Pharmacy | AccessPharmacy | McGraw Hill Medical
Read this chapter of Quick Answers: Pharmacy online now, exclusively on AccessPharmacy. AccessPharmacy is a subscription-based resource from McGraw Hill that features trusted pharmacy content from the best minds in the field.
https://accesspharmacy.mhmedical.com/content.aspx?bookid=2735§ionid=228232289
Neurology OverviewNeurology Overview
The terms above describe general types of diseases because they dont provide specific information about the cause of the disease process. Once the cause has been determined, the name may change. For example, the veterinarian may determine that a patient has inflammation of the meninges (i.e. meningitis). Once it has been determined that the meningitis is caused by an infection from the fungus, coccidiomycosis, the name will change to Cocci meningitis and the patient can be specifically treated for this disease process. Also, the suffix -us denotes an organism and -osis denotes a condition. Therefore, Cryptococcosis is an infection caused by the fungus Cryptococcus.. If multiple areas are being affected by a process, two or more prefixes can be combined. For example ...
http://vetneuro.com/index.php/resources/reference/neurology-overview
Unexpectedly high rate of multiple strains in fungal infectionUnexpectedly high rate of multiple strains in fungal infection
The researchers analyzed clinical cultures collected during a prospective study on cryptococcosis. Using molecular analysis of unpurified isolates they uncovered an unexpectedly high frequency (almost 20 percent) of mixed infections. They further demonstrated that these mixed infections could result from infestation by multiple strains acquired from the environment and that the strains were also evolving during infection.. The concept of one strain/one infection does not hold true for C neoformans and may apply to other environmentally acquired fungal pathogens. The possibility of mixed and/or evolving infections should be taken into account when developing therapeutic strategies against these pathogens, says Dromer.. mBio™ is a new open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related ...
http://www.innovations-report.com/html/reports/life-sciences/unexpectedly-high-rate-multiple-strains-fungal-155031.html
Package of prophylaxis against infections reduces the risk of death for people starting HIV treatment very late | aidsmapPackage of prophylaxis against infections reduces the risk of death for people starting HIV treatment very late | aidsmap
The primary study outcome was the death rate 24 weeks after starting treatment. Intent to treat analysis which counted everyone randomised showed that enhanced prophylaxis was associated with a significantly reduced risk of death. 8.9% of those in the enhanced prophylaxis arm died compared to 12.2% of those in the standard of care arm, a risk reduction of 27% (HR 0.73, 95% CI 0.54-0.97, p = 0.03) and this difference was sustained at week 48 (HR 0.75, 95% CI 0. 58-0.98, p = 0.04).. Analysis of the primary causes of death showed that death due to Cryptococcus was significantly reduced in the enhanced prophylaxis arm (p = 0.03) but there was no difference in rates of death due to TB or bacterial infections. The investigators concluded that, in most cases, the causes of death were multifactorial. Nevertheless, the study found that enhanced prophylaxis was associated with a reduction in new cases of TB, cryptococcal disease or candida, but not of bacterial infections. Hospitalisation for any cause ...
http://www.aidsmap.com/news/aug-2016/package-prophylaxis-against-infections-reduces-risk-death-people-starting-hiv
EPIC & Treating TBIEPIC & Treating TBI
The EPIC program has trained over 11,000 paramedics and EMTs to treat patients with traumatic brain injuries. Call the Scarlett Law Group to schedule a free consultation today.
https://www.scarlettlawgroup.com/blog/2019/may/epic-treating-traumatic-brain-injuries/
Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both...
TY - JOUR. T1 - Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both classical pathway activation and steric hindrance. AU - Zaragoza, Oscar. AU - Casadevall, Arturo. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/12. Y1 - 2006/12. N2 - The capsule of the human pathogenic fungus Cryptococcus neoformans presents the immune system with a formidable problem for phagocytosis. Capsule-mediated activation of the alternative complement (C) pathway results in component 3 (particularly, C3) binding to the capsule near the cell wall surface. Hence, for cells with large capsule, C3 cannot interact with the complement receptor (CR) and is not opsonic. However, C activation in either immune serum or in the presence of monoclonal antibody (mAb) to capsular polysaccharide localizes C3 to the capsular edge. When C.neoformans cells were coated with both C and antibody (Ab) opsonins, Ab bound first and ...
https://jhu.pure.elsevier.com/en/publications/monoclonal-antibodies-can-affect-complement-deposition-on-the-cap-3
The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by...
The lysis of infected cells by disease-causing microorganisms is an efficient but risky strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the hosts immune system. Cryptococcus neoformans is a widespread fungal pathogen that causes a fatal meningitis in HIV and other immunocompromised patients. Following intracellular growth, cryptococci are able to escape their host cells by a non-lytic expulsive mechanism that may contribute to the invasion of the central nervous system. Non-lytic escape is also exhibited by some bacterial pathogens and is likely to facilitate long-term avoidance of the host immune system during latency. Here we show that phagosomes containing intracellular cryptococci undergo repeated cycles of actin polymerisation. These actin flashes occur in both murine and human macrophages and are dependent on classical WASP-Arp2/3 complex mediated actin filament nucleation. Three dimensional confocal imaging time lapse revealed that such flashes ...
http://eprints.bham.ac.uk/893/
Table 3 - Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and...
Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus-based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9 - 143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C.
https://wwwnc.cdc.gov/eid/article/7/3/01-7302-t3
Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and...
TY - JOUR. T1 - Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responses. AU - Feldmesser, Marta. AU - Mednick, Aron. AU - Casadevall, Arturo. PY - 2002. Y1 - 2002. N2 - Cryptococcus neoformans, an encapsulated yeast, is a common cause of life-threatening meningoencephalitis in immunosuppressed patients. We previously observed that administration of a monoclonal antibody (MAb) to the capsular polysaccharide to mice with pulmonary infection prolonged survival and enhanced granulomatous inflammation without reducing lung CFU. To understand the mechanism of MAb action, we studied leukocyte recruitment and cytokine profiles in lungs of A/JCr mice. B lymphocytes were the predominant cell type in lung infiltrates, comprising 15 to 30% of the leukocytes. Despite alterations in histological appearance, fluorescence-activated cell sorter analysis revealed no significant difference in total numbers of lung ...
https://jhu.pure.elsevier.com/en/publications/antibody-mediated-protection-in-murine-cryptococcus-neoformans-in-3
First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe...First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe...
TY - JOUR. T1 - First identification of autochthonous Cryptococcus neoformans var. gattii isolated from goats with predominantly severe pulmonary disease in Spain. AU - Baró, Teresa. AU - Torres-Rodríguez, Josep M.. AU - De Mendoza, Miguel Hermoso. AU - Morera, Yolanda. AU - Alía, Concepción. PY - 1998/2/1. Y1 - 1998/2/1. N2 - Cryptococcus neoformans var. gattii is associated with Eucalyptus trees growing in various tropical and subtropical regions of the world. The identification of 13 autochthonous strains of C. neoformans var. gattii in Spain is reported. These strains were isolated from lung (10 samples), liver (1 sample), and brain (2 samples) tissue specimens from six goats suffering from predominantly severe pulmonary disease that were autopsied. The animals were members of five different herds of goats grazing in rural areas of the province of Caceres (Extremadura, Spain). Between 1990 and 1994, there were five outbreaks, in which between 2.5 and 12% of the goats were affected. ...
https://portalrecerca.uab.cat/en/publications/first-identification-of-autochthonous-cryptococcus-neoformans-var
Cryptococcus neoformans var. grubii Franzot et al. ATCC ® 208821DCryptococcus neoformans var. grubii Franzot et al. ATCC ® 208821D
Cryptococcus neoformans var. grubii ATCC ® 208821D-2™ Designation: Genomic DNA from Cryptococcus neoformans var. grubii strain H99JP [ATCC ® 208821™] Application:
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Fungi_and_Yeast/Fungal_and_Yeast_Genomic_DNA/208821D-2.aspx
Host immunity to Cryptococcus neoformans<...Host immunity to Cryptococcus neoformans<...
TY - JOUR. T1 - Host immunity to Cryptococcus neoformans. AU - Rohatgi, Soma. AU - Pirofski, Liise-anne. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected patients with profound T-cell deficiency. Where in use, combination antiretroviral therapy has markedly reduced the incidence of and risk for disease, but cryptococcosis continues to afflict those without access to therapy, particularly in sub-Saharan Africa and Asia. However, cryptococcosis also occurs in solid organ transplant recipients and patients with other immunodeficiencies as well as those with no known immunodeficiency. This article reviews innate and adaptive immune responses to C. neoformans, with an emphasis on recent studies on the role of B cells, natural IgM and Fc gamma receptor polymorphisms in resistance to cryptococcosis.. AB - Cryptococcosis is caused by the fungal ...
https://einstein.pure.elsevier.com/en/publications/host-immunity-to-cryptococcus-neoformans-2
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection ...
https://clinicaltrials.gov/show/NCT00001701?order=22
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection...
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection ...
https://clinicaltrials.gov/show/NCT00001701?order=242
Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic CirrhosisFatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis
Diagnosis of invasive cryptococcal infection in apparently nonimmunocompromised patients is difficult and often delayed. Human immunodeficiency virus- (HIV-) negative patients with decompensated hepatic cirrhosis might be at high risk of cryptococcal infection. We report here an 82-year-old Japanese female with end-stage hepatic failure and undergoing renal dialysis, hospitalized with septic shock-like symptoms. The patient had had hepatitis B virus (HBV) infection in the past. She survived only 4 days following admission. During hospitalization, she was found to have pleural effusion and ascites.|i| Cryptococcus neoformans|/i| was obtained from blood culture but not from pleural effusion culture. Consequently, the patient was diagnosed as having invasive cryptococcosis in association with HBV-related hepatic cirrhosis. Unfortunately, the patient died prior to receiving antifungal agents. Twelve Japanese cases of hepatic cirrhosis-related invasive cryptococcal infection, consisting of previously
https://www.hindawi.com/journals/crihep/2018/5174518/
Isolation of the Third Capsule-Associated Gene,CAP60, Required for Virulence in Cryptococcus neoformans | Infection and ImmunityIsolation of the Third Capsule-Associated Gene,CAP60, Required for Virulence in Cryptococcus neoformans | Infection and Immunity
A polysaccharide capsule is one of the most important virulence factors for the pathogenic fungus Cryptococcus neoformans. We previously characterized two capsule-associated genes,CAP59 and CAP64. To further dissect the molecular mechanism of capsule synthesis, 16 acapsular mutants induced by 4-nitroquinoline-1-oxide were obtained. The acapsular phenotype of one of these mutants was complemented. The cloned gene was designatedCAP60, and deletion of this newly described capsule-associated gene resulted in an acapsular phenotype. The proposed 67-kDa Cap60p contains 592 amino acids and appears to have a putative transmembrane domain close to the N terminus. DNA sequence analysis revealed that CAP60 has similarity toCAP59 at the center portion of its coding regions. Contour-clamped homogeneous electric field blot analysis suggested that these two genes are on the same chromosome. CAP60 andCAP59, however, could not be functionally substituted for each other by direct complementation or by domain swap ...
https://iai.asm.org/content/66/5/2230.abstract
ASMscience | Cryptococcus neoformans
The main principles for the genetic pathophysiology of cryptococcosis will probably be consistent among all three varieties. In this chapter the author considers the yeasts to be different varieties or serotypes. Seven major areas are examined to support the potential molecular insights into this pathogenic yeast which will allow one to identify drug targets, define drug resistance mechanisms, and/or prepare mutants or fungal products for protective fungal vaccines. Initial molecular biology studies focused on distinguishing molecular strain differences with the use of karyotypes, repetitive elements, and eventually randomly amplified polymorphic DNAs, amplification fragment length polymorphisms, and PCR fingerprinting for strain genotyping. Cryptococcus neoformans has several well-characterized virulence phenotypes which have been approached in their understanding by both genetic and molecular tools. Experimental cryptococcosis in animal models has tended to be associated with large inocula or some
http://www.asmscience.org/content/book/10.1128/9781555815776.ch21
CRYPTOCOCCOSIS | Harrisons Infectious Diseases, 3e | AccessBiomedical Science | McGraw-Hill MedicalCRYPTOCOCCOSIS | Harrisons Infectious Diseases, 3e | AccessBiomedical Science | McGraw-Hill Medical
Cryptococcal infection is acquired from the environment. C. neoformans and C. gattii inhabit different ecologic niches. C. neoformans is frequently found in soils contaminated with avian excreta and can easily be recovered from shaded and humid soils contaminated with pigeon droppings. In contrast, C. gattii is not found in bird feces. Instead, it inhabits a variety of arboreal species, including several types of eucalyptus tree. C. neoformans strains are found throughout the world; however, var. grubii (serotype A) strains are far more common than var. neoformans (serotype D) strains among both clinical and environmental isolates. The geographic distribution of C. gattii was thought to be largely limited to tropical regions until an outbreak of cryptococcosis caused by a new serotype B strain began in Vancouver in 1999. This outbreak has extended into the United States, and C. gattii infections are being encountered increasingly in several states in the Pacific Northwest. ...
http://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=2073§ionid=156824721
cryptococcal meningitis [Operative Neurosurgery]cryptococcal meningitis [Operative Neurosurgery]
In Japan, most cases of cryptococcosis are caused by Cryptococcus neoformans(C. neoformans). Until now, only three cases which the infectious agent was Cryptococcus neoformans var. gattii(C. gattii)have been reported. As compared with cryptococcosis caused by C. neoformans, which is often observed in immunocompromised hosts, cryptococcosis caused by C. gattii occurs predominantly in immunocompetent hosts and is resistant to antifungal drugs. Here, we report a case of refractory cerebral cryptococcoma that was successfully treated by surgical resection of the lesions. A 33-year-old man with no medical history complained of headache, hearing disturbance, and irritability. Pulmonary CT showed a nodular lesion in the left lung. Cerebrospinal fluid examination with Indian ink indicated cryptococcal meningitis, and PCR confirmed infection with C. gattii. C. gattii is usually seen in the tropics and subtropics. Since this patient imported trees and soils from abroad to feed stag beetles, parasite or ...
http://operativeneurosurgery.com/doku.php?id=cryptococcal_meningitis
Frontiers | TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary...Frontiers | TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary...
Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic potential of TNF-α supplementation as a booster of host anti-cryptococcal responses, we engineered a C. neoformans strain expressing murine TNF-α. Using a murine model of pulmonary cryptococcosis, we demonstrated that TNF-α-producing C. neoformans strain enhances protective elements of host response including preferential T-cell accumulation and improved Th1/Th2 cytokine balance, diminished pulmonary eosinophilia and alternative activation of lung macrophages at the adaptive phase of infection compared to wild type strain-infected mice. Furthermore, TNF-α expression by C. neoformans enhanced the fungicidal activity of macrophages in vitro. Finally, mice infected with the TNF-α-producing C. neoformans strain showed improved fungal control and considerably prolonged survival compared to wild type strain-infected mice,
https://www.frontiersin.org/articles/10.3389/fimmu.2019.01725/full
Cyclic AMP-Dependent Protein Kinase Controls Virulence of the Fungal Pathogen Cryptococcus neoformans | Molecular and Cellular...Cyclic AMP-Dependent Protein Kinase Controls Virulence of the Fungal Pathogen Cryptococcus neoformans | Molecular and Cellular...
Our studies define the elements of a signal transduction cascade that controls the production of virulence factors and pathogenicity ofC. neoformans. The Pka1 catalytic subunit of PKA regulates mating, melanin and capsule production, and virulence. The Pkr1 regulatory subunit of PKA is also a critical component, and mutants lacking Pkr1 overproduced capsule and were hypervirulent by several measures in two different animal models. pkr1 mutant cells also produced dramatically enlarged capsules during infection, and both the larger capsule size and the increased release of immunosuppressive capsular polysaccharides likely contribute to enhanced virulence.. Epistasis analysis further supports the conclusion that the Gα protein Gpa1 is an upstream controlling element for this signaling pathway and that the Ste12α transcription factor may represent one of several downstream targets of PKA that regulate differentiation and virulence. One interesting finding is that mutants with defects in an ...
https://mcb.asm.org/content/21/9/3179?ijkey=fd2a22fda6ee68eba825d2168b1ca45d55ce50e0&keytype2=tf_ipsecsha
1992 - Bronchoalveolar cryptococcal antigen was accurate for diagnosing cryptococcal pneumonia in immunocompromised...1992 - Bronchoalveolar cryptococcal antigen was accurate for diagnosing cryptococcal pneumonia in immunocompromised...
The study by Baughman and colleagues comprises 2 parts. The first part was a retrospective analysis of 51 patients, the results of which yielded 100% sensitivity and 100% specificity. The second part was a prospective study of 220 patients. 15 were positive for cryptococcal antigen in their BAL fluid, but only 8 of them had culture-proven cryptococcal pneumonia. On the basis of a 3.6% prevalence of cryptococcal infection in this group of patients, a negative predictive value of 100% was calculated. The authors also calculated a positive predictive value of 53% to 67% depending on the cut-point titer of antigen used. Because of the 7 false-positive antigen tests obtained from the prospective study, all antigen-positive and 10 antigen-negative BAL specimens were retested after they were stored at -80 °C for at least 3 months. All culture-positive specimens were antigen positive, but none of the 7 initially false-positive specimens remained positive, thus providing a 100% sensitivity and 100% ...
http://www.acpjc.org/Content/117/3/issue/ACPJC-1992-117-3-085.htm
Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of Caution | Annals of Internal Medicine | American College of...Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of Caution | Annals of Internal Medicine | American College of...
An article in a recent issue of this journal reported the use of intravenous miconazole in cryptococcosis (1). Use of this new antifungal drug in the treatment of systemic candidiasis as well as cryptococcosis appears to be increasing. Whereas relatively few infectious disease specialists use intravenous miconazole for these indications, we believe that this drug is used much more frequently by physicians working outside the subspecialty of infectious disease. If our impression is correct, then these groups differ in the interpretation of the meager data on the efficacy of miconazole in treating these diseases. Alternatively, some physicians may be relying ...
http://annals.org/aim/article-abstract/694810/miconazole-cryptococcosis-systemic-candidiasis-word-caution
Multiple Sclerosis Research: #ClinicSpeak & #NeuroSpeak: another case of cryptococcal infections with fingolimodMultiple Sclerosis Research: #ClinicSpeak & #NeuroSpeak: another case of cryptococcal infections with fingolimod
The case below of systemic cryptococcal infection and meningitis, an opportunistic fungal infection, in a pwMS on fingolimod is one of many cases reported worldwide. The problem with fingolimod is that you cant derisk the risk of opportunistic infections. All cases of opportunistic infection on fingolimod, to the best of my knowledge, have occurred in pwMS with lymphocyte counts above 200/mm3 or 0.2x109/L (the action level ti disruot dosing in the EU). In addition, infections in pwMS on fingolimod are not linked to the peripheral lymphocyte counts. Therefore, the only way to deal with the opportunistic infection risk on fingolimod is to remain vigilant and be aware of symptoms suggsetive of an infection. In the case of cryptococcal meningitis this may be very subtle symptoms; for example a non-specific headache or visual symptoms. The reason why cryptococcal infection is very indolent is simply because people who are immunosuppressed are unable to mount a vigorous immune response against the ...
https://multiple-sclerosis-research.blogspot.com/2016/11/clinicspeak-neurospeak-another-case-of.html
Cryptococcus neoformans | Infection and ImmunityCryptococcus neoformans | Infection and Immunity
The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the transportation and degradation of proteins. We determined that Vps27, a key protein of the ESCRT-0 complex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcus neoformans. Laccase activity was perturbed, as was melanin production, in ... ...
https://iai.asm.org/keyword/cryptococcus-neoformans
A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Crytococcus neoformans infection -...A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Crytococcus neoformans infection -...
Fingerprint Dive into the research topics of A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Crytococcus neoformans infection. Together they form a unique fingerprint. ...
https://einstein.pure.elsevier.com/en/publications/a-cryptococcal-capsular-polysaccharide-mimotope-prolongs-the-surv-2/fingerprints/
Assignment on Cryptococcosis - Assignment PointAssignment on Cryptococcosis - Assignment Point
Cryptococcosis is an infection caused by fungi that belong to the genus Cryptococcus.The two species are Cryptococcus neoformans and Cryptococcus gattii.
http://www.assignmentpoint.com/science/assignment-on-cryptococcosis.html
Jawaharlal Nehru Centre for Advanced Scientific ResearchJawaharlal Nehru Centre for Advanced Scientific Research
Aritreyee Datta*, Vikas Yadav*, ............, Kaustuv Sanyal, Ayyalusamy Ramamoorthy and Anirban Bhunia, Mode of Action of a Designed Antimicrobial Peptide: High Efficiency in Killing of the Human Fungal Pathogen Cryptococcus neoformans, Biophysical Journal 111, 1724 - 1737 (2016 ...
http://www.jncasr.ac.in/cpmupub.php?&dept_id=MBGU&yeartype=2016&empid=&pubtype=
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolatesSexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct varieties that infect most prominently the central nervous system. A sexual cycle involving haploid cells of a and alpha mating types has been reported for two varieties (C. neoformans var. neoformans, serotype …
https://pubmed.ncbi.nlm.nih.gov/12933823/?dopt=Abstract
RNA Interference in the Pathogenic Fungus Cryptococcus neoformans | GeneticsRNA Interference in the Pathogenic Fungus Cryptococcus neoformans | Genetics
Strains and cell growth: C. neoformans was grown with continuous shaking at 30° in YPD medium [1% (w/v) Bacto yeast extract; 2% (w/v) peptone, 2% dextrose] or minimal medium lacking uracil (Ausubelet al. 2001). Low adenine plates contained yeast nitrogen base supplemented with (per liter) 20 g glucose; 24 mg uracil; 40 mg each arginine, histidine, isoleucine, leucine, lysine, methionine, and tryrosine; 60 mg phenylalanine and tryptophan; 120 mg homoserine; 180 mg valine; and 10 mg adenine. For experiments using 5-fluoroorotic acid (5-FOA), plates contained the same medium with adenine raised to 40 mg/liter and the addition of 1 g/liter 5-FOA. Wild-type serotype D strain B4500 and cap59 strain TYCC33 (Chang and Kwon-Chung 1994) were from Dr. June Kwon-Chung (National Institutes of Health), and ura5 strain JEC43 (Wickeset al. 1997) was from Dr. Joseph Heitman (Duke University Medical Center). JEC43 cells transformed with a control plasmid alone (CIP-GUST.Cla.Kpn; see below) are designated ...
http://www.genetics.org/content/160/2/463
KMLE: 내과 해리슨(Harrison) 정리집KMLE: 내과 해리슨(Harrison) 정리집
Fungal infection 대장경 정리 ,Cryptococcosis, Cryptococcus neoformans 1. Cryptococcal meningoencephalitis 대부분 환자들이 진단당시에 meningoencephalitis를 가진다. fever, nuchal rigidity: 없거나 경하다. papilledema, cranial nerve palsy(25%): asymmetric * CSF: glucose↓, protein↑, lymphocyte pelocytosis serum, CSF capsular antigen test: 90%에서 detect가능(확인은 culture) 2. Cryptococcosis의 치료: Amphotericin-B, flucytosine 치료기간, AIDS가 없을 때: CSF tapping매주하여, India ink(-), glucose normal, 적어도 4주간 배양되지 않을때까지, 대략 6주정도 3. Cryptococcosis의 poor Px mentality↓, CSF WBC , 20/uL, cryptococcal Ag ,1:1024 ,Candidiasis, 4. Candida esophagitis 치료: Fluconazole(Diflucan) 1T qd × 7-14T 5. chronic disseminated candidiasis or hepatosplenic candidiasis neutropenia회복됨에도 불구하고 광범위 항균제 치료에 반응하지 않는 지속적 발열이 있을 때 의심 6. neutropenia환자의 acute ...
http://m.kmle.co.kr/harrisonview.php?m=%B6%F3%BD%C4&view=220+%B0%A8%BF%B0+%B3%BB%B0%FA+-+Fungal+infection%28%C1%F8%B1%D5+%B0%A8%BF%B0%29+%B4%EB%C0%E5%B0%E6+%C1%A4%B8%AE.htm
JCI - Pathogen-specific antibodies: codependent no longerJCI - Pathogen-specific antibodies: codependent no longer
Antibody-mediated defense against pathogens typically requires complex interactions between antibodies and other constituents of the humoral and cellular immune systems. However, recent evidence indicates that some antibodies alone can inhibit pathogen function in the absence of complement, phagocytes, or NK cells. In this issue of the JCI, McClelland et al. have begun to elucidate the molecular bases by which antibodies alone can impact pathogen growth and metabolism. They show that mAbs specific for the polysaccharide capsule of the human pathogenic fungus Cryptococcus neoformans elicit diverse effects on fungal gene expression, lipid biosynthesis, susceptibility to amphotericin B, cellular metabolism, and protein phosphorylation. These data suggest that pathogens have the capacity to generate broad metabolic responses as a result of surface binding by pathogen-specific antibodies, effects that may hold therapeutic promise. ...
https://www.jci.org/articles/view/42695/figure/1
JCI - Pathogen-specific antibodies: codependent no longerJCI - Pathogen-specific antibodies: codependent no longer
Antibody-mediated defense against pathogens typically requires complex interactions between antibodies and other constituents of the humoral and cellular immune systems. However, recent evidence indicates that some antibodies alone can inhibit pathogen function in the absence of complement, phagocytes, or NK cells. In this issue of the JCI, McClelland et al. have begun to elucidate the molecular bases by which antibodies alone can impact pathogen growth and metabolism. They show that mAbs specific for the polysaccharide capsule of the human pathogenic fungus Cryptococcus neoformans elicit diverse effects on fungal gene expression, lipid biosynthesis, susceptibility to amphotericin B, cellular metabolism, and protein phosphorylation. These data suggest that pathogens have the capacity to generate broad metabolic responses as a result of surface binding by pathogen-specific antibodies, effects that may hold therapeutic promise. ...
https://www.jci.org/articles/view/42695/pdf
Cryptococcus neoformans - Wikipedia
Infection wif C. neoformans is termed cryptococcosis. Most infections wif C. neoformans occur in de wungs.[12] However, fungaw meningitis and encephawitis, especiawwy as a secondary infection for AIDS patients, are often caused by C. neoformans, making it a particuwarwy dangerous fungus. Infections wif dis fungus are rare in dose wif fuwwy functioning immune systems.[13] So, C. neoformans is sometimes referred to as an opportunistic fungus.[13] It is a facuwtative intracewwuwar padogen[14] dat can utiwize host phagocytes to spread widin de body.[15][16] Cryptococcus neoformans was de first intracewwuwar padogen for which de non-wytic escape process termed vomocytosis was observed.[17][18] It has been specuwated dat dis abiwity to manipuwate host cewws resuwts from environmentaw sewective pressure by amoebae, a hypodesis first proposed by Arturo Casadevaww under de term accidentaw viruwence.[19]. In human infection, C. neoformans is spread by inhawation of aerosowized basidiospores, and can ...
http://wikien4.appspot.com/wiki/Cryptococcus_neoformans
Angina drug activity unveils possible new treatment strategy against cryptococcosis - Healio - News Archives UsaAngina drug activity unveils possible new treatment strategy against cryptococcosis - Healio - News Archives Usa
The researchers findings, printed within the Worldwide Journal of Antimicrobial Agents, indicate that fendiline hydrochloride can stimulate white-colored bloodstream cells to battle cryptococcosis, which can be more efficient than using drugs to directly get rid of the fungus.. Despite its effectiveness, a lesser dose (1 µM) of fendiline hydrochloride well suited for clinical use unsuccessful to avoid C. neoformans growth.. In reaction, the scientists screened 1,200 Food and drug administration-approved drugs to recognize effective compounds that could stimulate white-colored bloodstream cells to acknowledge and kill C. neoformans residing in cells, the discharge stated. Throughout a preliminary screening, 19 compounds put together to considerably hinder intra cellular development of C. neoformans. After additional screening processes ruling out compounds with host cell toxicity, the scientists discovered that fendiline hydrochloride, dosed at 5 µM, considerably enhanced phagosomal ...
http://newsy-today.com/angina-drug-activity-reveals-possible-new-treatment-strategy-against-cryptococcosis-healio/
Cryptococcus Infections Misdiagnosed in Many AIDS Patients - Healthcanal.com : Healthcanal.comCryptococcus Infections Misdiagnosed in Many AIDS Patients - Healthcanal.com : Healthcanal.com
The difference between these strains could make a difference in treatment, clinical course, and outcome, said Joseph Heitman, MD, PhD, senior author of the study and chair of the Duke Department of Molecular Genetics and Microbiology.. The study was published September 1 in PLoS Pathogens.. The study emphasizes that health professionals need to record the cryptococcal species more carefully to understand different clinical courses and possibly to change treatment strategies.. Researchers at Duke University Medical Center discovered that in the Los Angeles area, more than 12 percent of AIDS patients diagnosed with Crypotococcus were infected with C. gattii, much higher than earlier studies, which suggested that only about 1 percent have C. gattii. The researchers based these figures on molecular testing of fungal DNA barcodes.. This discovery comes at the same time as a C. gattii outbreak is expanding in the Pacific Northwest, spreading southward from Vancouver, British Columbia, through ...
https://www.healthcanal.com/infections/20296-cryptococcus-infections-misdiagnosed-in-many-aids-patients.html
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans • Research - Institut PasteurSystematic functional profiling of transcription factor networks in Cryptococcus neoformans • Research - Institut Pasteur
Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its overall biological and pathogenic regulatory circuits remain elusive,
https://research.pasteur.fr/en/publication/systematic-functional-profiling-of-transcription-factor-networks-in-cryptococcus-neoformans/
ECR 2018 / C-0919 / Central nervous system cryptococcosis in immunocompetent and immunocompromised patients: clinical...ECR 2018 / C-0919 / Central nervous system cryptococcosis in immunocompetent and immunocompromised patients: clinical...
Poster: ECR 2018 / C-0919 / Central nervous system cryptococcosis in immunocompetent and immunocompromised patients: clinical presentations and imaging features by: F. LEITÃO1, P. COIMBRA2, P. M. Brasil1, J. Benevides Lima1, D. Brilhante1, T. Camara da Silva1, K. portela luz1, L. P. PEREIRA1, C. Leite Macedo Filho1; 1Fortaleza/BR, 2Fortaleza, CEARA/BR
https://epos.myesr.org/esr/viewing/index.php?module=viewing_poster&task=&pi=144395
The role of Notch signaling in host defenses to Cryptococcus neoformans (P3310) | The Journal of ImmunologyThe role of Notch signaling in host defenses to Cryptococcus neoformans (P3310) | The Journal of Immunology
Cryptococcus neoformans (C. neoformans) is a major opportunistic fungal pathogen in individuals with impaired T cell-mediated immunity. Notch pathway is an important signaling component of immunological synapse during APC/T-cell engagement. Little is known about the role of Notch signaling in fungal infections. We sought to determine the role of Notch signaling in C. neoformans infection. Wild-type C57BL/6 (WT) and CD4-Cre+×ROSA DNMAML (DNMAML) mice were infected intratracheally infected with C. neoformans. The fungal burden, leukocyte recruitment, and cytokine profile were assessed at 3 and 6 weeks post-infection (wpi). A 50-fold greater fungal burden was detected in both lungs and brains of DNMAML mice compared to those in the WT mice at 6 wpi. Although, equivalent fungal burdens were found at 3 wpi in WT and DNMAML groups, the production of IFN-γ, IL-4, and IL-13 was significantly decreased in lung leukocytes of DNMAML mice. In contrast, an equivalent induction of IL-17 was observed in both ...
http://www.jimmunol.org/content/190/1_Supplement/134.8
Fine-Needle Aspiration and Cryptococcosis in the Acquired Immunodeficiency Syndrome (AIDS) | Annals of Internal Medicine |...Fine-Needle Aspiration and Cryptococcosis in the Acquired Immunodeficiency Syndrome (AIDS) | Annals of Internal Medicine |...
To the editor: In their evaluation of fine-needle aspiration biopsies of lymph nodes in patients with the acquired immunodeficiency syndrome (AIDS)-related conditions, Bottles and colleagues (1) emphasize the usefulness of this method for diagnosing malignancy, Kaposi sarcoma, and mycobacterial infection. We report a case in which the diagnosis of disseminated cryptococcosis was made on the basis of a routine May-Grünwald-Giemsa-stained lymph node specimen from fine-needle aspiration biopsy.. A 33-year-old black patient from Angola had lost weight and had night sweats and fever. Physical examination showed cervical, nontender small lymph nodes (0.5 to 1 cm). Mild splenomegaly was present. ...
http://annals.org/aim/article-abstract/701465/fine-needle-aspiration-cryptococcosis-acquired-immunodeficiency-syndrome-aids
Cryptococcus laurentii (Kufferath) Skinner ATCC ® 18803™Cryptococcus laurentii (Kufferath) Skinner ATCC ® 18803™
Cryptococcus laurentii ATCC ® 18803™ Designation: CBS 139 [CCRC 20527, CCY 17-3-2, DBVPG 6265, IFO 0609, IFO 0906, MUCL 30398, NRRL Y-2536, VKM Y-1665, VKPM Y-219] Application: Produces xylan endo-1,3-beta-xylosidase xylan hydrolase, xylanase Quality control strain Quality control strain for API products Control strain for identification
https://www.atcc.org/Products/Quality_Control_Strains/By_Organization__Company/18803.aspx
Giant Cells Protect Potentially Deadly Fungus During Infection | www.bioquicknews.comGiant Cells Protect Potentially Deadly Fungus During Infection | www.bioquicknews.com
Giant cells called titan cells created by the fungus Cryptococcus neoformans protect the fungus during infection, according to two University of Minnesota researchers. Kirsten Nielsen, Ph.D., an assistant professor in the department of microbiology, and recent Ph.D. recipient Laura Okagaki believe their discovery could help develop new ways to fight infections caused by Cryptococcus. The findings will be published in the June 2012 issue of the journal Eukaryotic Cell. Cryptococcus, a fungus frequently found in dust and dirt, is responsible for the deaths of more than 650,000 AIDS patients worldwide each year. It is also a potentially deadly concern among chemotherapy and organ transplant patients. Currently, Cryptococcus causes more annual deaths in sub-Saharan Africa than tuberculosis. While most healthy individuals are resistant to Cryptococcus infections, the fungus can cause deadly disease for those with already weak immune systems, said Dr. Nielsen. When inhaled, Cryptococcus can cause ...
http://www.bioquicknews.com/node/859
Disease Outbreak Control Division | Cryptococcosis (Cryptococcus gattii, C. gattii)Disease Outbreak Control Division | Cryptococcosis (Cryptococcus gattii, C. gattii)
Inhalation of the airborne C.gattii fungus from the environment. The fungus can be found in the environment, in the soil and trees in tropical and sub-tropical regions of the world (Australia, Papua New Guinea, Africa, Asia, Europe, Mexico and South America). In the united states, C. gattii has been found in Washington, Oregon, California and Hawaii.. There is no human to human or human and animal spread of infection. Infection is only via inhalation of the yeast cells or spores.. ...
https://health.hawaii.gov/docd/disease_listing/cryptococcosis-cryptococcus-gattii-c-gattii/
Pulmonary Cryptococcosis Presenting Solitary Pulmonary Nodule in an Immunocompetence: A Case Report and Review of the Korean...Pulmonary Cryptococcosis Presenting Solitary Pulmonary Nodule in an Immunocompetence: A Case Report and Review of the Korean...
폐 효모균증 치료의 목적은 폐렴의 증상과 징후의 조절, 파종의 예방, 그리고 재발의 방지 등이다. 일반적으로 면역기능과 증상의 정도에 따라 기간과 용량에 차이가 있으며, 가장 흔하게 사용되는 항진균제는 fluconazole를 비롯하여 심각한 증상의 경우에는 amphotericin B, flucytocin 등을 사용하며, itraconazole을 대체제로 사용할 수 있다[2,14,15]. 그러나 면역기능이 정상인 환자에서는 파종성의 증거가 없거나 전신적 증상이 없는 경우는 항진균제 치료 없이도 호전될 수 있음을 보여준 경우도 있으나 [6] , 경증 이상의 경우는 fluconazole을 하루에 400 mg, 3-6개월 또는 12개월까지 사용함을 추천하고 있다 [15] . 국내의 증례에서는 고립성 폐결절로 발현된 면역기능이 정상인 환자에서 초기 내원 시 조직검사를 거부한 환자에서 3개월 뒤 2배 이상 커진 증례가 있었다 [12] . 본 ...
http://jsms.sch.ac.kr/journal/view.php?doi=10.15746/sms.11.026
UQ study targets lethal fungal infection - UQ News - The University of Queensland, AustraliaUQ study targets lethal fungal infection - UQ News - The University of Queensland, Australia
The development of new drugs to fight a common fungal pathogen which kills half a million people globally each year is a step closer thanks to a University of Queensland-led study.. UQ PhD student Jessica Chitty of the Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, said the study targeted the fungus Cryptococcus neoformans, which had shown signs of becoming resistant to current medications.. This is a fungus that can be found around the world and when inhaled, its microscopic cells can cause infection in people with a weakened immune system, she said.. Infections are particularly prevalent in people with advanced AIDS but can also occur in transplant recipients and those on immunosuppressive medication.. Recently two rare cases of Cryptococcus neoformans infections occurred in Australia in immunocompetent people.. Co-author Associate Professor James Fraser said drugs used to treat the disease have been around for a few decades and consequently ...
http://www.uq.edu.au/news/article/2017/07/uq-study-targets-lethal-fungal-infection
Pheromones and Titan Cell Production in Cryptococcus neoformans - Kirsten NielsenPheromones and Titan Cell Production in Cryptococcus neoformans - Kirsten Nielsen
Pheromones and pheromone receptors have long been known to affect virulence of the opportunistic pathogen Cryptococcus neoformans, yet it is still entirely uncl...
http://grantome.com/grant/NIH/R01-AI080275-04
Miliary pulmonary cryptococcosis in a patient with the acquired immunodeficiency syndrome. | ThoraxMiliary pulmonary cryptococcosis in a patient with the acquired immunodeficiency syndrome. | Thorax
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
https://thorax.bmj.com/content/48/4/402.info
CryptococcosisCryptococcosis
... can rarely occur in the non-immunosuppressed people, particularly with Cryptococcus gattii. Cryptococcosis is a ... Any person who is found to have cryptococcosis at a site outside of the central nervous system (e.g., pulmonary cryptococcosis ... Primary Cutaneous Cryptococcosis (PCC) is a distinct clinical diagnosis separate from the secondary cutaneous cryptococcosis ... are especially susceptible to disseminated cryptococcosis. Cryptococcosis is often fatal, even if treated. It is estimated that ...
https://en.wikipedia.org/wiki/Cryptococcosis
Opportunistic infectionOpportunistic infection
Cryptococcus neoformans is a fungus that causes cryptococcosis, which can lead to pulmonary infection as well as nervous system ... Maziarz EK, Perfect JR (March 2016). "Cryptococcosis". Infectious Disease Clinics of North America. 30 (1): 179-206. doi: ... the etiologic agents of cryptococcosis". Cold Spring Harbor Perspectives in Medicine. 4 (7): a019760. doi:10.1101/cshperspect. ...
https://en.wikipedia.org/wiki/Opportunistic_infection
Rhoda Williams BenhamRhoda Williams Benham
With F. C. Bocobo.) Cryptococcosis and blastomycosis. Ann. New York Acad. Sci. 50: 1299-1314. 1950. The Laboratory of Medical ... Benham, Rhoda W. (September 1950). "CRYPTOCOCCOSIS AND BLASTOMYCOSIS". Annals of the New York Academy of Sciences. 50 (10): ...
https://en.wikipedia.org/wiki/Rhoda_Williams_Benham
CryptococcusCryptococcus
"What is Cryptococcus infection (cryptococcosis)?". Center for Disease Control and Prevention. April 28, 2010. Retrieved 8 March ... Some Cryptococcus species cause a disease called cryptococcosis. The genus was described by French mycologist Jean Paul ...
https://en.wikipedia.org/wiki/Cryptococcus
Cryptococcus neoformansCryptococcus neoformans
Infection with C. neoformans is termed cryptococcosis. Most infections with C. neoformans occur in the lungs. However, fungal ... If cryptococcal meningitis occurs, mortality rate is between 10 and 30%. Cryptococcosis that does not affect the central ... "Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis". The Journal of Clinical ...
https://en.wikipedia.org/wiki/Cryptococcus_neoformans
Gilberts potorooGilbert's potoroo
In a later study of a long-nosed potoroo, the same symptoms were found and were likened to a fatal disease, cryptococcosis, ... "Cryptococcosis in Gilbert's and long-nosed potoroo". Journal of Zoo and Wildlife Medicine. 38 (4): 567-73. doi:10.1638/2007- ...
https://en.wikipedia.org/wiki/Gilbert's_potoroo
Arturo CasadevallArturo Casadevall
Cryptococcosis, in: Infectious disease clinics of North America. Vol. 16, nº 4; 837-874. 2001, with JN Steenbergen and HA ... Urease as a virulence factor in experimental cryptococcosis, in: Infection and Immunity. Vol. 68, nº 2; 443-448. 1999, with ...
https://en.wikipedia.org/wiki/Arturo_Casadevall
GeotrichosisGeotrichosis
Cryptococcosis, Trichosporonosis and Geotrichosis". JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 11 (5): 381-394 ...
https://en.wikipedia.org/wiki/Geotrichosis
NickelNickel
"Urease as a Virulence Factor in Experimental Cryptococcosis". Infection and Immunity. 68 (2): 443-448. doi:10.1128/IAI.68.2.443 ...
https://en.wikipedia.org/wiki/Nickel
Fungal infectionFungal infection
Examples of opportunistic mycoses include Candidiasis, Cryptococcosis and Aspergillosis.[citation needed] Most common mild ... Systemic fungal infections are more serious and include cryptococcosis, histoplasmosis, pneumocystis pneumonia, aspergillosis ... Systemic fungal infections include histoplasmosis, cryptococcosis, coccidioidomycosis, blastomycosis, mucormycosis, ... 1F22 Blastomycosis 1F23 Candidosis 1F24 Chromoblastomycosis 1F25 Coccidioidomycosis 1F26 Conidiobolomycosis 1F27 Cryptococcosis ...
https://en.wikipedia.org/wiki/Fungal_infection
Otto BusseOtto Busse
In 1894 Busse was the first to provide a written account of cryptococcosis, caused by a yeast-like fungus now known as ... Hanns von Meyenburg NCBI One hundred years of cryptococcosis. Medical mycology in the 19th century in Greifswald ...
https://en.wikipedia.org/wiki/Otto_Busse
FungusFungus
These include aspergillosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mycetomas, and ...
https://en.wikipedia.org/wiki/Fungus
TalaromycosisTalaromycosis
Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis". Current Infectious Disease Reports. 19 (10): 36. doi: ... after extrapulmonary tuberculosis and cryptococcosis) in HIV-positive individuals within the endemic area of Southeast Asia. ...
https://en.wikipedia.org/wiki/Talaromycosis
Talaromyces marneffeiTalaromyces marneffei
Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis". Current Infectious Disease Reports. 19 (10): 36. doi: ... with fever and anaemia similar to disseminated cryptococcosis. This contrasted with related Penicillium species that are ...
https://en.wikipedia.org/wiki/Talaromyces_marneffei
FluconazoleFluconazole
This includes candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis ...
https://en.wikipedia.org/wiki/Fluconazole
Caseous necrosisCaseous necrosis
A similar appearance can be associated with histoplasmosis, cryptococcosis, and coccidioidomycosis. This begins as infection is ...
https://en.wikipedia.org/wiki/Caseous_necrosis
CoccidioidomycosisCoccidioidomycosis
Barron MA, Madinger NE (November 18, 2008). "Opportunistic Fungal Infections, Part 3: Cryptococcosis, Histoplasmosis, ...
https://en.wikipedia.org/wiki/Coccidioidomycosis
HistoplasmosisHistoplasmosis
Barron MA, Madinger NE (November 18, 2008). "Opportunistic Fungal Infections, Part 3: Cryptococcosis, Histoplasmosis, ...
https://en.wikipedia.org/wiki/Histoplasmosis
Lactiplantibacillus plantarumLactiplantibacillus plantarum
CNS Cryptococcosis in HIV at eMedicine Tsuda H, Matsumoto T, Ishimi Y (2011). "Biotin, niacin, and pantothenic acid assay using ... resulting in an AIDS-defining illness such as cryptococcosis, representing 60% to 70% of all AIDS-defining cases, but not ...
https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum
Amphotericin BAmphotericin B
... and cryptococcosis. For certain infections it is given with flucytosine. It is typically given intravenously (injection into a ... and Abelcet for treatment of systemic murine cryptococcosis". Antimicrobial Agents and Chemotherapy. 42 (4): 899-902. doi: ...
https://en.wikipedia.org/wiki/Amphotericin_B
FlucytosineFlucytosine
It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by ...
https://en.wikipedia.org/wiki/Flucytosine
John E. Bennett (scientist)John E. Bennett (scientist)
Bennett researches pathogenesis, diagnosis, treatment, prevention, and epidemiology of mycoses, particularly cryptococcosis and ... these patients are surprisingly difficult to treat compared to those with AIDS and cryptococcosis. A major cause of morbidity ... searching for genetic markers in the patients and their families that might have predisposed patients to cryptococcosis, ... and evaluating potential new treatments for cryptococcosis. Bennett's honors include master in the American College of ...
https://en.wikipedia.org/wiki/John_E._Bennett_(scientist)
Liise-anne PirofskiLiise-anne Pirofski
She studies the immune response to the mycosis Cryptococcosis and the bacterium Streptococcus pneumoniae. She has explored ...
https://en.wikipedia.org/wiki/Liise-anne_Pirofski
House crowHouse crow
They have also been found to carry Cryptococcus neoformans, which can cause cryptococcosis in humans. House crows in Tanzania ...
https://en.wikipedia.org/wiki/House_crow
Reverse zoonosisReverse zoonosis
Typical examples of sapronotic agents are fungal such as coccidioidomycosis, histoplasmosis, aspergillosis, cryptococcosis, ...
https://en.wikipedia.org/wiki/Reverse_zoonosis
List of dog diseasesList of dog diseases
Cryptococcosis* is a fungal disease caused by Cryptococcus neoformans that affects both dogs and humans. It is a rare disease ...
https://en.wikipedia.org/wiki/List_of_dog_diseases
GranulomaGranuloma
Infections characterized by granulomas include tuberculosis, leprosy, histoplasmosis, cryptococcosis, coccidioidomycosis, ...
https://en.wikipedia.org/wiki/Granuloma
SapronosisSapronosis
Typical examples of sapronotic agents are fungal such as coccidioidomycosis, histoplasmosis, aspergillosis, cryptococcosis, ...
https://en.wikipedia.org/wiki/Sapronosis
Cryptococcus gattiiCryptococcus gattii
... causes the human diseases of pulmonary cryptococcosis (lung infection), basal meningitis, and cerebral ... "A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)". ...
https://en.wikipedia.org/wiki/Cryptococcus_gattii
Mouth ulcerMouth ulcer
Fungal causes include Coccidioides immitis (valley fever), Cryptococcus neoformans (cryptococcosis), and Blastomyces ...
https://en.wikipedia.org/wiki/Mouth_ulcer
C. gattii Infections | Fungal Disease | CDCC. gattii Infections | Fungal Disease | CDC
C. gattii cryptococcosis is a rare infection that people can get after breathing in the microscopic fungus. The infection can ...
https://www.cdc.gov/fungal/diseases/cryptococcosis-gattii/
Cryptococcosis - WikipediaCryptococcosis - Wikipedia
Cryptococcosis. Other names. Busse-Buschke disease, cryptococcic meningitis, cryptococcosis lung, cryptococcosis skin, European ... "Cryptococcosis". NORD (National Organization for Rare Disorders). Retrieved 5 June 2021.. *^ "Cryptococcosis". Lexico UK ... "Cryptococcosis". Merriam-Webster Dictionary. Retrieved 2016-01-21.. *^ a b c d "ICD-11 - ICD-11 for Mortality and Morbidity ... Primary Cutaneous Cryptococcosis[edit]. Primary Cutaneous Cryptococcosis (PCC) is a distinct clinical diagnosis separate from ...
https://en.wikipedia.org/wiki/Cryptococcosis
CryptococcosisCryptococcosis
HomeMedical CenterDisease sheetsCryptococcosis. Cryptococcosis. Cryptococcus neoformans, the fungus responsible for ... Cryptococcosis is responsible for 15% of deaths related to human immunodeficiency virus (HIV), the majority in Sub-Saharan ... Cryptococcosis is a severe fungal infection that occurs in immunocompromised patients. The most frequent clinical form of ... In France, around 40% of cryptococcosis cases are HIV-related.. Transmission. The fungus Cryptococcus neoformans is present in ...
https://www.pasteur.fr/en/medical-center/disease-sheets/cryptococcosis
Cryptococcosis: MedlinePlus Medical EncyclopediaCryptococcosis: MedlinePlus Medical Encyclopedia
Cryptococcosis is infection with the fungi Cryptococcus neoformans or Cryptococcus gattii. ... Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, ... Kauffman CA, Chen SC-A. Cryptococcosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: ... Robles WS, Ameen M. Cryptococcosis. In: Lebwohl MG, Heymann WR, Murrell DF, eds. Treatment of Skin Disease: Comprehensive ...
https://medlineplus.gov/ency/article/001328.htm
Cryptococcosis Medication: Antifungal agentsCryptococcosis Medication: Antifungal agents
encoded search term (Cryptococcosis) and Cryptococcosis What to Read Next on Medscape ... Cryptococcosis Medication. Updated: May 11, 2021 * Author: Pradeep Kumar Mada, MD, MRCP(UK); Chief Editor: Pranatharthi Haran ... Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses. Clin Infect Dis. 2016 Aug 1. 63 (3):356-62. [QxMD MEDLINE Link ... Rapid diagnosis of cryptococcosis using an antigen detection immunochromatographic test. J Infect. 2015 May. 70 (5):499-503. [ ...
https://www.medscape.com/answers/215354-106263/which-medications-in-the-drug-class-antifungal-agents-are-used-in-the-treatment-of-cryptococcosis
Cryptococcosis: Symptoms, Treatment, Diagnosis, Prevention & CausesCryptococcosis: Symptoms, Treatment, Diagnosis, Prevention & Causes
Cryptococcus gattii and Cryptococcus neoformans are two fungi that cause cryptococcosis when inhaled. Read about symptoms, ... What Causes Cryptococcosis?. *Cryptococcosis is found worldwide; the predominant way the disease is spread is through ... What Is the Medical Definition of Cryptococcosis?. *Cryptococcosis is a disease caused by fungi from the genus Cryptococcus ... Cryptococcosis - Signs and Symptoms What were the initial signs and symptoms of your Cryptococcosis infection? ...
https://www.emedicinehealth.com/cryptococcosis/article_em.htm
Cryptococcosis | DermNetCryptococcosis | DermNet
European cryptococcosis, European blastomycosis, Busse Buschkes disease, Busse Buschke disease. Authoritative facts from ... Cryptococcosis, Torula, European Blastomycosis, Torulosis, Infection by Cryptococcus neoformans, ... What is cryptococcosis?. Cryptococcosis is a fungal infection caused by inhaling the fungus Cryptococcus neoformans, which is ... What are the causes and risk factors for cryptococcosis?. The most common cryptococcosis infections (C. neoformans var ...
https://dermnetnz.org/topics/cryptococcosis
cryptococcosis - Ontology Report - Rat Genome Databasecryptococcosis - Ontology Report - Rat Genome Database
Busse-Buschkes disease; European cryptococcosis; Toruloses; cryptococcal infection; cryptococcoses; torula; torulosis. related ...
https://rgd.mcw.edu/rgdweb/ontology/annot.html?acc_id=DOID:12053&species=Mouse
EN (en)EN (en)
Pulmonary cryptococcosis is the consequence of the inhalation of Cryptococcus neoformans, an encapsulated yeast, from various ... most of the immunocompetent hosts and always in those with any kind of immunodeficiency with isolated pulmonary cryptococcosis. ...
https://research.pasteur.fr/en/publication/pulmonary-cryptococcosis/
Invasive Cryptococcosis and Adalimumab Treatment - Volume 13, Number 6-June 2007 - Emerging Infectious Diseases journal - CDC
Pulmonary cryptococcosis after initiation of anti-tumor necrosis factor-alpha therapy. Chest. 2003;124:2395-7. DOIPubMedGoogle ... The association between cryptococcosis and use of TFN-α antagonists can be explained by the immune response to C. neoformans, ... Invasive Cryptococcosis and Adalimumab Treatment. Volume 13, Number 6-June 2007. Article Views: 282. Data is collected weekly ... Invasive Cryptococcosis and Adalimumab Treatment. Emerging Infectious Diseases. 2007;13(6):953-955. doi:10.3201/eid1306.070154. ...
https://wwwnc.cdc.gov/eid/article/13/6/07-0154_article
Sporotrycosis, Cryptococcosis and Pythiosis Therapy - WSAVA2002 - VINSporotrycosis, Cryptococcosis and Pythiosis Therapy - WSAVA2002 - VIN
In all cases cryptococcosis in cats as well in dogs (rare in Brazil), the use of itraconazole (alone or in association with ... CRYPTOCOCCOSIS. The common protocol is the same recommended for feline sporotrichosis, that is, the single use of itraconazole ... 50 mg/cat/day for nasal and dermal cryptococcosis, and 2,5-10 mg/kg/day for cryptococcal meningitis); -ß lipid complex-ABLC- ( ...
https://www.vin.com/apputil/content/defaultadv1.aspx?id=3846164&pid=11147&
View of Nasal Cryptococcosis Caused by Cryptococcus gattii in Sheep in Bahia, Northeastern BrazilView of Nasal Cryptococcosis Caused by Cryptococcus gattii in Sheep in Bahia, Northeastern Brazil
Return to Article Details Nasal Cryptococcosis Caused by Cryptococcus gattii in Sheep in Bahia, Northeastern Brazil Download ...
https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/104135/pdf
PRIME PubMed | Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from...PRIME PubMed | Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from...
Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven ... pulmonary cryptococcosis due to capsule-intact Cr. neoformans. Download Prime PubMed App to iPhone, iPad, or Android ... Pulmonary cryptococcosis: a case report.. *Pathology in practice. Systemic cryptococcosis caused by C. neoformans and ... AdultAgedAntigens, FungalCryptococcosisCryptococcus neoformansHumansLungLung Diseases, FungalMiddle AgedPolysaccharides ...
https://www.unboundmedicine.com/medline/citation/15679661/Proven_pulmonary_cryptococcosis_due_to_capsule_deficient_Cryptococcus_neoformans_does_not_differ_clinically_from_proven_pulmonary_cryptococcosis_due_to_capsule_intact_Cr__neoformans_
Cryptococcosis Pipeline Drugs and Companies, 2021- Phase, Mechanism of Action, Route, Licensing/Collaboration, Pre-clinical and...Cryptococcosis Pipeline Drugs and Companies, 2021- Phase, Mechanism of Action, Route, Licensing/Collaboration, Pre-clinical and...
Cryptococcosis Pipeline Drugs and Companies, 2021- Phase, Mechanism of Action, Route, Licensing/Collaboration, Pre-clinical and ... 4. Cryptococcosis Drug Profiles. 4.1 Current Status of Cryptococcosis Drug Candidates, 2021. 4.2 Cryptococcosis Drugs in ... 3 Cryptococcosis Pipeline Snapshot, 2021. 3.1 Cryptococcosis Pipeline Drugs- Dominant phase type. 3.2 Cryptococcosis pipeline ... 7. Cryptococcosis News and Deals. 7.1 Recent Cryptococcosis Market Developments. 7.2 Pipeline Drug News Updates. 7.3 Pipeline ...
https://www.researchandmarkets.com/reports/5464050/cryptococcosis-pipeline-drugs-and-companies-2021
10th International Conference on Cryptococcus and Cryptococcosis (ICCC10) :: ISHAM10th International Conference on Cryptococcus and Cryptococcosis (ICCC10) :: ISHAM
ISHAM provided funding to the 10th International Conference on Cryptococcus and Cryptococcosis that was held in Foz do Iquacu, ... Current:10th International Conference on Cryptococcus and Cryptococcosis (ICCC10). 10th International Conference on ...
https://www.isham.org/about-isham/isham-funded-meeting-events/example-funded-event
Recent advances in cryptococcosis, candidiasis and coccidioidomycosis complicating HIV infection. | Profiles RNS
Kappe R, Levitz S, Harrison TS, Ruhnke M, Ampel NM, Just-Nübling G. Recent advances in cryptococcosis, candidiasis and ...
https://profiles.umassmed.edu/display/61509
cryptococcosis - General Practice notebookcryptococcosis - General Practice notebook
The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2022 Oxbridge Solutions Ltd®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions Ltd® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook ...
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Dynamic research of serum cryptococcal capsular polysaccharide antigen test and chest CT of pulmonary cryptococcosis without HIVDynamic research of serum cryptococcal capsular polysaccharide antigen test and chest CT of pulmonary cryptococcosis without HIV
The ERS-education website provides centralised access to all educational material produced by the European Respiratory Society. It is the worlds largest CME collection for lung diseases and treatment offering high quality e-learning and teaching resources for respiratory specialists. This distance learning portal contains up-to-date study material for the state-of-the-art in Pulmonology.
https://dev.ers-education.org/lr/show-details/?idP=238359
Cluster of Donor-Derived Cryptococcosis after Liver and Kidney TransplantationCluster of Donor-Derived Cryptococcosis after Liver and Kidney Transplantation
Cryptococcosis Humans Immunocompromised Host Kidney Kidney Transplantation Liver Liver Transplantation Postoperative ... Cryptococcosis infection after transplantation is easily overlooked or misdiagnosed. We report a cluster of donor-derived ... Title : Cluster of Donor-Derived Cryptococcosis after Liver and Kidney Transplantation Personal Author(s) : Sha, Meng;Shen, ... cryptococcosis infection in liver and kidney transplant recipients from the same donor in China. Infections occurred within 1 ...
https://stacks.cdc.gov/view/cdc/122488
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí ...Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí ...
Throughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the ... GENOTYPES OF CRYPTOCOCCUS NEOFORMANS AND CRYPTOCOCCUS GATTII AS AGENTS OF ENDEMIC CRYPTOCOCCOSIS IN TERESINA, PIAUÍ ( ... Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí ( ... gattii VGII-induced primary cryptococcosis and early cryptococcal infection. Lethality occurred in 18/37 (48.6%) of the HIV- ...
https://www.arca.fiocruz.br/handle/icict/37110
Treatment for Cryptococcosis Gets FDAs Orphan Drug Designation - Infectious Disease AdvisorTreatment for Cryptococcosis Gets FDA's Orphan Drug Designation - Infectious Disease Advisor
Cryptococcosis is a fungal disease that affects the lungs or central nervous system and is caused by either Cryptococcus ... The FDA has granted Orphan Drug designation to APX001 (Amplyx Pharmaceuticals) for the treatment of cryptococcosis.. ... The FDA has already granted APX001 Qualified Infectious Disease Product (QIDP) designation for the treatment of cryptococcosis ... Neutrophil Counts in PLWHIV With Cryptococcosis Linked to Mortality Risk. *Benefits Associated With Primary Antifungal ...
https://www.infectiousdiseaseadvisor.com/home/topics/mycoses/treatment-for-cryptococcosis-gets-fdas-orphan-drug-designation/
cryptococcosis | SyncSci Publishingcryptococcosis | SyncSci Publishing
Tag: cryptococcosis. Cryptococcus neoformans meningitis in an immunocompetent adult: A case report. November 18, 2020. Medicine ...
https://www.syncsci.com/tag/cryptococcosis/
Cryptococcosis | Gamuts.netCryptococcosis | Gamuts.net
Cryptococcosis. Cryptococcosis, sometimes informally called crypto, is a potentially fatal fungal disease caused by a few ... Cryptococcosis May Cause. Air-space opacity in leukemia or lymphoma. Arteritis. Basilar cistern intense enhancement. Chronic ... species of Cryptococcus (most often Cryptococcus neoformans or Cryptococcus gattii). Cryptococcosis is believed to be acquired ...
http://www.gamuts.net/display.php?id=22195
Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation<...Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation<...
Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation. In: The ... Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation. The ... Dive into the research topics of Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated ... Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation. / ...
https://abdn.pure.elsevier.com/en/publications/protective-immunity-against-pulmonary-cryptococcosis-is-associate
Cryptococcosis - Rare Gastroenterology NewsCryptococcosis - Rare Gastroenterology News
FDA-approved indication: Treatment of disseminated cryptococcosis including meningitis. .. National Library of Medicine Drug ...
https://www.rareginews.com/rarediseases/cryptococcosis/
IMSEAR at SEARO: Cutaneous cryptococcosis.
Cutaneous cryptococcosis. Journal of the Association of Physicians of India. 2004 Mar; 52(): 242-3. ...
https://imsear.searo.who.int/handle/123456789/93180
CRYPTOCOCCOSIS | Harrisons Manual of MedicineCRYPTOCOCCOSIS | Harrison's Manual of Medicine
CRYPTOCOCCOSIS answers are found in the Harrisons Manual of Medicine powered by Unbound Medicine. Available for iPhone, iPad, ... CRYPTOCOCCOSIS is a topic covered in the Harrisons Manual of Medicine. To view the entire topic, please log in or purchase a ... Cryptococcosis due to C. neoformans is rare in the absence of impaired immunity; in contrast, C. gattiirelated disease often ... Cryptococcosis due to C. neoformans is rare in the absence of impaired immunity; in contrast, C. gattiirelated disease often ...
https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623285/all/CRYPTOCOCCOSIS?q=INFECTION+MALASSEZIA
Introduction to Cryptococcosis - Science Dictionary
Introduction to Cryptococcosis May 15, 2022. May 15, 2022. sciencedict Cryptococcosis is one of the most important human fungal ... What is cryptococcosis?. The pathogens are found on blades of grass and seeds, which are ingested by birds, mostly pigeons, and ... In most cases, cryptococcosis affects the entire body. However, they can also remain localized to a single region, which is ... Cryptococcosis becomes particularly dangerous as soon as it enters the bloodstream. From this point on, the secondary stage is ...
https://www.sciencedict.com/introduction-to-cryptococcosis/
cryptococcosis Archives - Trauma Scene Bio Servicescryptococcosis Archives - Trauma Scene Bio Services
Angina Drug Could Inform a New Strategy to Fight Cryptococcosis planetadmin. June 8, 2016. Mould, NewsLeave a Comment ... used in the treatment of angina could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis. ...
https://traumascenebio.ca/tag/cryptococcosis/
Cryptococcosis Market Growth Archives - Page Bookmarks
Cryptococcosis Market - Competitive Analysis with Forecast to 2027 Shrikant Mandlik 2 months ago in Healthcare 0 ...
https://pagebookmarks.com/story-tag/cryptococcosis-market-growth/
InfectionPulmonaryNeoformansGattiiIncidence of cryptococcosisCluster of Donor-Derived CryptococcosisFungal diseaseAntifungalMeningitisFungusCoccidioidomycosisClinicalPrevalenceCases of cryptococcosisCutaneous2022Causes CryptococcosisCryptosporidiosisInfectionsAspergillosisSymptomsAIDSNonspecificCandidiasisFatalImmunocompromised patientsTreatmentInhalationMacrophagesTransplantationMicrographRarelyPrognosisPneumoniaImmunodeficiencySearchAffects
Infection27
  • C. gattii cryptococcosis is a rare infection that people can get after breathing in the microscopic fungus. (cdc.gov)
  • Cryptococcosis is a potentially fatal fungal infection of mainly the lungs , presenting as a pneumonia , and brain , where it appears as a meningitis . (wikipedia.org)
  • Cryptococcosis is a common opportunistic infection for AIDS , and is particularly common among people living with AIDS in Africa . (wikipedia.org)
  • Primary Cutaneous Cryptococcosis (PCC) is a distinct clinical diagnosis separate from the secondary cutaneous cryptococcosis that is spread from systematic infection. (wikipedia.org)
  • Cryptococcosis is a severe fungal infection that occurs in immunocompromised patients. (pasteur.fr)
  • Cryptococcosis is infection with the fungi Cryptococcus neoformans or Cryptococcus gattii . (medlineplus.gov)
  • Cryptococcosis is a disease caused by fungi from the genus Cryptococcus that infect humans and animals, usually by inhalation of the fungus , which results in lung infection that may spread to the brain, causing meningoencephalitis. (emedicinehealth.com)
  • Humans and animals usually get the infection from inhaling dust contaminated with bird feces, but humans do not transmit cryptococcosis to other humans or animals. (emedicinehealth.com)
  • The major causes of cryptococcosis are infection by C. neoformans and C. gattii . (emedicinehealth.com)
  • Cryptococcosis is a fungal infection caused by inhaling the fungus Cryptococcus neoformans , which is primarily found in soils enriched with pigeon droppings. (dermnetnz.org)
  • The most common cryptococcosis infections ( C. neoformans var neoformans ) affect people with immunodeficiency , for example, patients on high doses of corticosteroids , cancer chemotherapy patients, organ transplantation patients, and patients with acquired immune deficiency (AIDS) and HIV infection. (dermnetnz.org)
  • Recent advances in cryptococcosis, candidiasis and coccidioidomycosis complicating HIV infection. (umassmed.edu)
  • The occurrence of C. gattii VGII in six apparently healthy children and in seven adolescents/young adults in this region reaffirms the endemic occurrence of C. gattii VGII-induced primary cryptococcosis and early cryptococcal infection. (fiocruz.br)
  • Cryptococcosis is an opportunistic infection, which means that people who are particularly immunocompromised are affected by Cryptococcus neoformans. (sciencedict.com)
  • A drug more commonly used in the treatment of angina could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis. (traumascenebio.ca)
  • Although the diagnosis of CNS cryptococcosis is made on the basis of a series of microbiologic investigations, computed tomography (CT) scanning and magnetic resonance imaging (MRI) are important diagnostic techniques in any patient with HIV infection or a patient with acquired immunodeficiency syndrome (AIDS) and neurologic dysfunction. (medscape.com)
  • Several studies have shown that MRI is superior to CT in detecting abnormalities in patients with CNS cryptococcosis,[8] but with both imaging modalities, the number of lesions revealed is fewer than the number seen on pathologic examination[9] Normal MRI findings do not exclude CNS cryptococcosis, because the typical features of this infection occur in only 40% of patients. (medscape.com)
  • Cryptococcosis is an opportunistic infection, it often affects people who are immune -compromised, such as people who have AIDS. (coursehero.com)
  • Although the most common presentation of cryptococcosis is of C. neoformans infection in an immunocompromised person (such as persons living with AIDS), the C. gattii is being increasingly recognised as a pathogen in presumptively immunocompetent hosts, especially in Canada and Australia. (coursehero.com)
  • Cryptococcosis is a defining opportunistic infection for AIDS. (coursehero.com)
  • Cryptococcosis infection after transplantation is easily overlooked or misdiagnosed. (cdc.gov)
  • We report a cluster of donor-derived cryptococcosis infection in liver and kidney transplant recipients from the same donor in China. (cdc.gov)
  • Cryptococcosis is the third most common invasive fungal infection in solid-organ transplants ( 1 , 2 ). (cdc.gov)
  • Another feature of recipient-acquired cryptococcosis is the late onset of infection, which usually is 15‒21 months posttransplant ( 7 ). (cdc.gov)
  • Cryptococcosis is an invasive fungal infection in SLE, perhaps due to the de novo immune defect. (nature.com)
  • Because cryptococcosis is an important invasive fungal infection in SLE, we examined the immune responses of FcγRIIb−/− mice to Cryptococcus neoformans, in vivo and in vitro . (nature.com)
  • One experiment revealed that 84 percent of the samples taken from pigeon droppings in roosting sites had a significant amount of infection in them, including Cryptococcosis. (atexpest.com)
Pulmonary17
  • Pulmonary cryptococcosis is the consequence of the inhalation of Cryptococcus neoformans, an encapsulated yeast, from various environmental sources. (pasteur.fr)
  • Antifungal treatment has to be given in most of the immunocompetent hosts and always in those with any kind of immunodeficiency with isolated pulmonary cryptococcosis. (pasteur.fr)
  • Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven pulmonary cryptococcosis due to capsule-intact Cr. (unboundmedicine.com)
  • We compared the clinical manifestations, laboratory and radiologic findings, and outcomes of eight patients with proven pulmonary cryptococcosis (PC) caused by capsule-deficient Cryptococcus neoformans with those of six patients with PC caused by capsule-intact Cr. (unboundmedicine.com)
  • Update on Pulmonary Cryptococcosis. (nih.gov)
  • Pulmonary cryptococcosis: A review of pathobiology and clinical aspects. (bvsalud.org)
  • Pulmonary cryptococcosis is an important opportunistic invasive mycosis in immunocompromised patients , but it is also increasingly seen in immunocompetent patients . (bvsalud.org)
  • In contrast to cryptococcal meningitis , pulmonary cryptococcosis is still underdiagnosed because of limitations in diagnostic tools. (bvsalud.org)
  • Pulmonary nodules are the most common radiological feature, but these are not specific to pulmonary cryptococcosis . (bvsalud.org)
  • Cryptococcal antigen (CrAg) with lateral flow device is a fast and sensitive test and widely used on serum and cerebrospinal fluid , but sera from patients with pulmonary cryptococcosis are rarely positive in the absence of disseminated disease . (bvsalud.org)
  • Detection of CrAg from respiratory specimens might assist the diagnosis of pulmonary cryptococcosis but there are very few data. (bvsalud.org)
  • The first line of treatment for pulmonary cryptococcosis is fluconazole , or amphotericin B and flucytosine for those with central nervous system involvement. (bvsalud.org)
  • Pulmonary cryptococcosis worsens the prognosis of cryptococcal meningitis . (bvsalud.org)
  • In this review , we summarize the biological aspects of Cryptococcus and provide an update on the diagnosis and management of pulmonary cryptococcosis . (bvsalud.org)
  • Radiological findings of pulmonary cryptococcosis may include nonspecific lung nodules or masses indistinguishable from lung cancer or pulmonary tuberculosis. (mssm.edu)
  • A raised index of suspicion for pulmonary cryptococcosis with careful attention to travel history is expected to facilitate timely diagnosis. (mssm.edu)
  • Dectin-2 polymorphism associated with pulmonary cryptococcosis in HIV-uninfected Chinese patients. (nih.gov)
Neoformans11
  • The main infectious agent responsible for cryptococcosis is the fungus Cryptococcus neoformans , an encapsulated yeast mainly spread by airborne transmission that is present in soil and organic debris. (pasteur.fr)
  • Perfect JR. Cryptococcosis ( Cryptococcus neoformans and Cryptococcus gattii ). (medlineplus.gov)
  • The vast majority of cryptococcosis infections are caused by C. neoformans and C. gattii . (emedicinehealth.com)
  • Risk factors for cryptococcosis caused by C. neoformans are inhalation of fungi that are associated with various bird droppings or guano, especially from pigeons. (emedicinehealth.com)
  • Risk factors for cryptococcosis caused by C. gattii are different from C. neoformans . (emedicinehealth.com)
  • Throughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the northern and northeastern states. (fiocruz.br)
  • Cryptococcosis is a fungal disease that affects the lungs or central nervous system and is caused by either Cryptococcus neoformans or Cryptococcus gattii, 2 species of the fungus Cryptococcus which are typically found in the environment. (infectiousdiseaseadvisor.com)
  • Cryptococcosis, sometimes informally called crypto, is a potentially fatal fungal disease caused by a few species of Cryptococcus (most often Cryptococcus neoformans or Cryptococcus gattii). (gamuts.net)
  • The incidence of cryptococcosis in transplant recipients was estimated to be 0.76% in mainland China, and the Cryptococcus neoformans variant grubii genotype was the predominant species ( 3 - 5 ). (cdc.gov)
  • Mortality, after intravenous C. neoformans -induced cryptococcosis, in young (8-week-old) and older (24-week-old) FcγRIIb−/− mice, was higher than in age-matched wild-types. (nature.com)
  • C. neoformans causes cryptococcosis and is often found in bird manure accumulations. (cdc.gov)
Gattii2
  • The three strains of C. gattii that are most frequently found causing cryptococcosis are designated VGlla, VGllb, and VGllc. (emedicinehealth.com)
  • Distribution of cryptococcosis caused by C. gattii months. (cdc.gov)
Incidence of cryptococcosis2
  • Recent studies highlight the high incidence of cryptococcosis among patients in certain resource-poor areas, where there is also a high incidence of AIDS. (elsevier.com)
  • Formerly a rare infectious disease, the incidence of cryptococcosis has increased because of its frequent occurrence among HIV-infected persons. (cdc.gov)
Cluster of Donor-Derived Cryptococcosis2
  • We report a cluster of donor-derived cryptococcosis after liver and kidney transplantation in China. (cdc.gov)
  • Transplanted liver tissue biopsy specimen on postoperative day 30 from donor in cluster of donor-derived cryptococcosis, China. (cdc.gov)
Fungal disease1
  • Cryptococcosis, or cryptococcal disease, is a potentially fatal fungal disease. (coursehero.com)
Antifungal1
  • Despite the availability of antifungal agents with anticryptococcal activity, the mortality and treatment-failure rates associated with cryptococcosis remain unacceptably high. (elsevier.com)
Meningitis2
  • FDA-approved indication: Treatment of disseminated cryptococcosis including meningitis . (rareginews.com)
  • HIV-infected patients with treated cryptococcal meningitis (CM) are at risk of further neurological deterioration (ND) after commencing combination antiretroviral therapy (cART), mostly due to cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). (edu.au)
Fungus3
  • A micrograph of cryptococcus (purple), the fungus that can cause cryptococcosis. (coursehero.com)
  • Cryptococcosis has rarely been reported from Egypt although a number of factors would predict the country to be an area where the fungus would be common. (who.int)
  • Another common fungus that breeds in a pigeon's droppings and in roosting nests is cryptococcosis, which is a disease fungus. (atexpest.com)
Coccidioidomycosis1
  • The FDA has already granted APX001 Qualified Infectious Disease Product (QIDP) designation for the treatment of cryptococcosis, as well as for invasive candidiasis, invasive aspergillosis, and coccidioidomycosis. (infectiousdiseaseadvisor.com)
Clinical6
  • The most common clinical form of cryptococcosis is disseminated meningoencephalitis (in more than 60% of cases, and in more than 80% of cases in patients with HIV). (pasteur.fr)
  • What are the clinical features of cryptococcosis? (dermnetnz.org)
  • This chapter in Cryptococcosis preclinical and clinical trials assists in gaining clear understanding of the timetable developments in Cryptococcosis product area. (researchandmarkets.com)
  • Preclinical and clinical trial details of pipeline candidates for Cryptococcosis are detailed in the report. (researchandmarkets.com)
  • Clinical and mycological predictors of cryptococcosis-associated Immune reconstitution inflammatory syndrome (C-IRIS). (edu.au)
  • Cryptococcosis after transplantation is easily overlooked because of high diversity of clinical symptoms, which leads to mortality rates as high as 20% ( 6 ). (cdc.gov)
Prevalence3
  • [18] The prevalence of cryptococcosis has been increasing over the past 50 years for many reasons, including the increase in incidence of AIDS and the expanded use of immunosuppressive drugs. (wikipedia.org)
  • Although the prevalence of cryptococcosis has decreased among HIV-infected patients, it still accounts for over 600,000 deaths each year globally, mainly in areas with less access to antiviral treatments. (medscape.com)
  • The prevalence of cryptococcosis has been increasing over the past 20 years for many reasons, including the increase in incidence of AIDS and the expanded use of immunosuppressive drugs. (coursehero.com)
Cases of cryptococcosis2
  • The Spanish registry of adverse events of biologic therapies in rheumatic diseases reported that 1,080 patients were treated with adalimumab from 2003 through 2006 and no cases of cryptococcosis were recorded ( 2 ). (cdc.gov)
  • No cases of cryptococcosis have been detected in 10,050 treated patients in the US postmarketing database for adalimumab ( 3 ). (cdc.gov)
Cutaneous3
  • Further, route of administration including oral, topical, sub-cutaneous, IV, ophthalmic and others are provided to assist researchers to understand most sought and least sought route of Cryptococcosis drug administration. (researchandmarkets.com)
  • IMSEAR at SEARO: Cutaneous cryptococcosis. (who.int)
  • Cutaneous cryptococcosis. (who.int)
20221
  • Global Cryptococcosis Market from 2022 to 2028 has completed a report on MarketsandResearch.biz . (bosswomenrule.com)
Causes Cryptococcosis1
Cryptosporidiosis1
  • Some diseases such as cryptococcosis (extrapulmonary form), chronic intestinal cryptosporidiosis, salmonellosis (non-typhoid), cerebral toxoplasmosis, and Chagas' disease (reactivated form) are also included in the Centers for Disease Control and Prevention (CDC) criterion that was adapted from the definition of AIDS 8 8. (scielo.br)
Infections3
  • With the global emergence of AIDS, cryptococcosis is now one of the most common life-threatening fungal infections in these patients. (dermnetnz.org)
  • Cryptococcosis is one of the most important human fungal infections. (sciencedict.com)
  • Severe systemic fungal infections with susceptible pathogens, as an alternative or when switching from parenteral use, particularly: candidiasis, cryptococcosis, chromoblastomycosis and certain forms of aspergillosis. (who.int)
Aspergillosis1
  • candidiasis, cryptococcosis, chromoblastomycosis and certain forms of aspergillosis. (who.int)
Symptoms2
  • Contact your provider if you develop symptoms of cryptococcosis, especially if you have a weakened immune system. (medlineplus.gov)
  • This is why some individuals show brain changes as their first symptoms of having cryptococcosis. (emedicinehealth.com)
AIDS1
  • Therefore, cryptococcosis is also counted among the AIDS - defining diseases. (sciencedict.com)
Nonspecific1
  • CT scan findings are often nonspecific for CNS cryptococcosis. (medscape.com)
Candidiasis1
  • Flucytosine must be used in combination, to avoid as much as possible the selection of resistant organisms, especially in the treatment of candidiasis and cryptococcosis. (who.int)
Fatal2
  • Cryptococcosis is a disease caused by fungi that can be fatal. (coursehero.com)
  • Cryptococcosis is often fatal, even if treated. (coursehero.com)
Immunocompromised patients1
  • A multicenter, longitudinal cohort study of 145 HIV-negative immunocompromised patients with cryptococcosis found 49% had CNS involvement. (medscape.com)
Treatment2
  • What is the treatment for cryptococcosis? (dermnetnz.org)
  • This article reviews current treatment strategies and the basis for these strategies, as well as prospects for future approaches to the treatment of cryptococcosis. (elsevier.com)
Inhalation1
  • Cryptococcosis is believed to be acquired by inhalation of the infectious propagule from the environment. (gamuts.net)
Macrophages1
  • In summary, prominent phagocytosis, with limited effective killing activity, and high pro-inflammatory cytokine production by FcγRIIb−/− macrophages were correlated with more severe cryptococcosis in FcγRIIb−/− mice. (nature.com)
Transplantation1
  • The outcomes and optimal management of cirrhotic patients who develop cryptococcosis before transplantation are not fully known. (elsevier.com)
Micrograph1
  • Micrograph of cryptococcosis showing the characteristically thick capsule of cryptococcus. (wikipedia.org)
Rarely1
  • Cryptococcosis is rarely transmitted directly into the skin (by laboratory accidents) and by organ transplants. (emedicinehealth.com)
Prognosis1
  • Cryptococcosis in patients with cirrhosis has grave prognosis. (elsevier.com)
Pneumonia1
  • We diagnosed her as pneumocystis pneumonia and cryptococcosis. (or.jp)
Immunodeficiency1
  • Cryptococcosis is responsible for 15% of deaths related to human immunodeficiency virus (HIV) , the majority in Sub-Saharan Africa. (pasteur.fr)
Search1
  • Whenever cryptococcosis occurs at any site, carefully search for lesions elsewhere, both inside and outside the CNS. (medscape.com)
Affects1