Cryoglobulins
Cryoglobulinemia
Paraproteinemias
Rheumatoid Factor
Complement Activating Enzymes
Antigen-Antibody Complex
Vasculitis, Leukocytoclastic, Cutaneous
Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Immunoglobulin G
Complement C1q
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Complement C3
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Complement C4
Immunoglobulin M
Antibodies, Anti-Idiotypic
Glomerulonephritis, Membranoproliferative
Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Hepatitis C, Chronic
Waldenstrom Macroglobulinemia
A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.
Immunodiffusion
Nephelometry and Turbidimetry
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Diagnostic Techniques and Procedures
Reflex
Plasticizers
Systemic Vasculitis
Staphylococcus aureus
Opsonin Proteins
Staphylococcus
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Organically Modified Ceramics
Blood Proteins
Vitelline Duct
Lasers
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Complement receptor 1 (CD35) on human reticulocytes: normal expression in systemic lupus erythematosus and HIV-infected patients. (1/235)
The low levels of complement receptor 1 (CR1) on erythrocytes in autoimmune diseases and AIDS may be due to accelerated loss in the circulation, or to a diminished expression of CR1 on the red cell lineage. Therefore, we analyzed the expression of CR1 on reticulocytes (R) vs erythrocytes (E). Healthy subjects had a significant higher CR1 number per cell on R (919 +/- 99 CR1/cell) than on E (279 +/- 30 CR1/cell, n = 23), which corresponded to a 3. 5- +/- 1.3-fold loss of CR1. This intravascular loss was confirmed by FACS analysis, which showed that all R expressed CR1, whereas a large fraction of E was negative. The systemic lupus erythematosus (SLE), HIV-infected, and cold hemolytic Ab disease (CHAD) patients had a CR1 number on R identical to the healthy subjects, contrasting with a lower CR1 on their E. The data indicated a significantly higher loss of CR1 in the three diseases, i.e., 7.0- +/- 3.8-, 6.1- +/- 2.9-, and 9.6- +/- 5.6-fold, respectively. The intravascular loss was best exemplified in a patient with factor I deficiency whose CR1 dropped from 520 CR1/R to 28 CR1/E, i.e., 18.6-fold loss. In one SLE patient and in the factor I-deficient patient, the FACS data were consistent with a loss of CR1 already on some R. In conclusion, CR1 is lost progressively from normal E during in vivo aging so that old E are almost devoid of CR1. The low CR1 of RBC in autoimmune diseases and HIV-infection is due to a loss occurring in the circulation by an active process that remains to be defined. (+info)Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports. (2/235)
OBJECTIVE: To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING: Hospitals in United Kingdom and Ireland. SUBJECTS: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. MAIN OUTCOME MEASURES: Death, "wrong" blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. RESULTS: Over 24 months, 366 cases were reported, of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return. CONCLUSIONS: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood. (+info)Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. (3/235)
In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of the classical complement pathway with deposition of C3 is pathogenic in lupus nephritis. Although the alternative complement pathway is activated in lupus nephritis, its role in disease pathogenesis is unknown. To determine the role of the alternative pathway in lupus nephritis, complement factor B-deficient mice were backcrossed to MRL/lpr mice. MRL/lpr mice develop a spontaneous lupus-like disease characterized by immune complex glomerulonephritis. We derived complement factor B wild-type (B+/+), homozygous knockout (B-/-), and heterozygous (B+/-) MRL/lpr mice. Compared with B+/- or B+/+ mice, MRL/lpr B-/- mice developed significantly less proteinuria, less glomerular IgG deposition, and decreased renal scores as well as lower IgG3 cryoglobulin production and vasculitis. Serum C3 levels were normal in the B-/- mice compared with significantly decreased levels in the other two groups. These results suggest that: 1) factor B plays an important role in the pathogenesis of glomerulonephritis and vasculitis in MRL/lpr mice; and 2) activation of the alternative pathway, either by the amplification loop or by IgA immune complexes, has a prominent effect on serum C3 levels in this lupus model. (+info)Cytoplasmic inclusions in leukocytes. An unusual manifestation of cryoglobulinemia. (4/235)
Cryoglobulins are circulating immunoglobulins characterized by reversible, cold-induced precipitation. A variety of laboratory abnormalities, including hypocomplementemia, elevated erythrocyte sedimentation rate, rheumatoid factor activity, pseudoleukocytosis, and pseudothrombocytosis, are associated with cryoglobulinemia. Extracellular, faintly basophilic, amorphous deposits of cryoglobulins occasionally have been described in blood smears. In the present study, smears prepared from blood collected at room temperature from 6 patients with cryoglobulinemia exhibited neutrophil and, occasionally, monocyte inclusions containing clear, light pink, or faintly basophilic amorphous material. The inclusions were absent in smears from blood collected and maintained at 37 degrees C. Ultrastructural examination revealed that the material within the leukocyte inclusions was consistent with phagocytosed immunoglobulins. The identification of characteristic cytoplasmic inclusions in leukocytes may be an important clue in the early recognition of cryoglobulinemia. (+info)Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. (5/235)
The distribution on the cell surface of the large external LETS protein that is transformation sensitive of normal, transformed and tumorigenic cells was examined by immunofluorescent staining. A correlation was established between the expression of fibril-like LETS protein and the oncogenic capabilities of a series of adenovirus-transformed cell lines. In cells expressing a transformed phenotype in vitro, LETS protein is only detected in cell-cell contact areas, wheras in "untransformed" cells LETS protein is distributed over the cell surface. Transformed cells capable of inducing invasive tumors, and the cells of established tumor lines, have low or undetectable levels of LETS protein, as measured by this method. The results indicate that LETS protein has a role in cell-cell adhesion and that reduced expression of this protein at the cell surface is related to the oncogenic phenotype. This relationship has been established for experimentally induced and spontaneous tumors. (+info)Complement fixation by rheumatoid factor. (6/235)
The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantly reduce the level of total hemolytic complement, CH50, or of individual complement components, C1, C2, C3, and C5. However, sheep erythrocytes (SRC) coated with Agg-R/A-IgG or with reduced and alkylated rabbit IgG anti-SRC antibody were hemolyzed by complement in the presence of polyclonal IgM-RF. Human and guinea pig complement worked equally well. The degree of hemolysis was in direct proportion to the hemagglutination titer of the RF against the same coated cells. Monoclonal IgM-RF, normal human IgM, and purified Waldenstrom macroglobulins without antiglobulin activity were all inert. Hemolysis of coated SRC by RF and complement was inhibited by prior treatment of the complement source with chelating agents, hydrazine, cobra venom factor, specific antisera to C1q, CR, C5, C6, or C8, or by heating at 56 degrees C for 30 min. Purified radiolabeled C4, C3, and C8 included in the complement source were bound to hemolysed SRC in direct proportion to the degree of hemolysis. These data indicate that polyclonal IgM-RF fix and activate complement via the classic pathway. The system described for assessing complement fixation by isolated RF is readily adaptable to use with whole human serum. (+info)Cryofibrinogenaemia: a study of 49 patients. (7/235)
The purpose of this study was to characterize the clinical features and components of 30 patients with isolated cryofibrinogen (CF) versus those of 19 patients with combined CF and cryoglobulins (CG). Secondary forms of cryofibrinogenaemia associated with collagen disorders, infectious or malignant diseases, were significantly more frequent in patients with combined CF and CG than those with isolated CF (79 versus 47%, P = 0.02). Both groups of CF patients presented predominantly cutaneous symptoms (77% in isolated CF; 58% in combined CF + CG), and less frequently venous and/or arterial thrombosis (13% in isolated CF; 3% in combined CF + CG). Patients with idiopathic forms of CF, and particularly those without CG, suffered essentially from recurrent painful skin ulcers, mainly triggered by cold exposure. Patients with isolated CF had higher mean plasma concentrations of CF than those with combined CF + CG (1. 61 +/- 1.26 versus 0.82 +/- 1.18 g/l, respectively; P = 0.004), but there was no correlation between the CF plasma level and either the severity of symptoms or the sensitivity to cold. In patients with isolated CF, fibronectin was suggested (by precipitation analysis) to be a major component of the cryoprecipitate, whereas immunoglobulins were rarely present (in only three out of 30 patients). By contrast, in the majority of patients (78%) with combined CF and CG, the CF consisted mainly of immunoglobulins of the same class as those characterizing the associated CG. Analysis of the CG precipitate revealed the presence of fibronectin but not fibrinogen, alpha1-antitrypsin and alpha2-macroglobulin. In conclusion, isolated and combined cryofibrinogenaemia are associated with different clinical signs requiring different clinical management, but there is no evidence as yet for a causal role of the cryoprecipitates in the differences observed. (+info)Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus. (8/235)
Although the association of cryoglobulinemia with hypocomplementemia and tissue injury in systemic lupus erythematosus is well recognized, composition of cryoprecipitates in terms of circulating antigens and antibodies in this disease is less clear. To clarify this question, cryoprecipitates from patients with SLE were examined with sensitive assay techniques for certain antipolynucleotide antibodies and DNA antigen. DNA antibodies were highly enriched relative to serum levels in the majority of cryoprecipitates. DNA antigen was also demonstrable. Antibody to ribonucleoprotein, although less frequently present, was similarly enriched in certain cryoprecipitates. In contrast, anti-double strand RNA, which was commonly detectable in relatively high titer in serum, was only minimally concentrated in a minority of cryoprecipitates. Absorption experiments using red blood cells heavily coated with polynucleotide antigen indicated that a major proportion of the IgG in certain cryoprecipitates was specific antibody. The data strongly suggest that the cryoprecipitates in systemic lupus erythematosus represent circulating immune complexes that are soluble at 37 degrees C and come out of solution in the cold. The marked concentration of immune complexes in the cryoglobulin offers a simple and direct method for determination of the nature of the complexes. The accumulated evidence obtained in the present study indicates that these complexes closely reflect, in their composition, the circulating immune complexes which are most significant pathogenetically in renal tissue injury. (+info)
A Waldenstrom macroglobulin that is both a cold agglutinin and a cryoglobulin because it binds N-acetylneuraminosyl residues<...
Cryoglobulins vs. Cold Agglutinins | Medicine Specifics
Nephron Power: Consult Rounds: Cryoglobulins and the Kidney
Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active...
Cryoglobulinemia: Background, Pathophysiology, Epidemiology
Immune System Archives | Ask Hematologist | Understand Hematology
Cryoglobulin, Qualitative with Reflex to Quantitative IgA, IgG, & IgM
Cryoglobulin serum - Things You Didnt Know
Acute Arterial Ischemia in a Patient With Polyarthritis | Reumatología Clínica
Improving Access to HCV Treatment: The Clinicians Role
CD4+ T Lymphocytes and Cryoglobulins in Patients Coinfected with HIV and Hepatitis C Virus: Forgetting the Hidden CD4+ Cell...
Online Rx Store: 50 mg viagra effectiveness free delivery!
About the Cover - March 06, 2020, 15 (3) | American Society of Nephrology
LAA037Ra71 | 纤连蛋白(FN)多克隆抗体(生物素标记) | Rattus norvegicus (Rat,大鼠) USCN(武汉优尔生商贸有限公司)
KSA037Bo01 | 纤连蛋白(FN)检测试剂盒DIY材料(酶联免疫吸附试验法) | Bos taurus; Bovine (Cattle,牛) USCN(武汉优尔生商贸有限公司)
Allergy Archives - Nut Health
Cryoglobulin | UCLA Health Library, Los Angeles, CA
Cryoglobulin | Northwestern Medicine
Cryoglobulin
Cryoglobulin
Cryoglobulin
Cryoglobulin
Nanotechnology Now - News Story: Bushs Secret Revenge
Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody<...
Lake Elsinore CA Internist Doctors - Essential Mixed Cryoglobulinemia: Symptoms, Treatment
Broomfield CO Internist Doctors - Essential Mixed Cryoglobulinemia: Symptoms, Treatment
I Have Cryofibrinogenemia Also : I Have Cryofibrinogenemia Story & Experience
Plus it
Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia | IRIS Università di Pisa
Asian Science Citation Index - Articles written by C Monk
Notes from Dr. RW: Hepatitis C-a multisystem disease
A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial...
Ulcerative Colitis Abdominal Distension
Cryogobulinemia Blood Collection Supplies - Alliance for Cryoglobulinemia
FRI0282 Serological biomarkers of b-cell lymphoproliferative disorders in patients with primary sjögrens syndrome:...
Clinical study of children with cryofibrinogenemia: a retrospective study from a single center | springermedizin.de
Cancer Chemotherapy and Raynauds Phenomenon | Annals of Internal Medicine | American College of Physicians
Mixed cryoglobulinemia - pdf descargar
Contact Us - Alliance for Cryoglobulinemia
Cryoglobulinemia - Symptoms and causes - Mayo Clinic
A Houston Woman Thought She Had Cancer, The Real Problem Was Cryoglobulinemia | Look A Side
Kako se kalio češki krimić. Umjetnost krimića Jana Cigáneka i nova kriminalistička proza 1960
卷烟主流烟气气溶胶中酚类物质的粒径分布研究
Cold agglutinin disease - Clinical Pain Advisor
Cold Agglutinin Disease (CAD) Epidemiology Forecast | Cold Agglutinin Disease (CAD) Prevalent population
How to Warm up Without Damage When you Have Cold Agglutinin Disease - Cold Agglutinin Disease News
CAD & Treatments | Cold Agglutinin Disease Foundation
Cold Agglutinin Disease | Ask Hematologist | Understand Hematology
4 Tips for Dealing with Cold Agglutinin Disease in Cold Weather - Cold Agglutinin Disease News
Cold agglutinin disease revisited: A multinational, observational study of 232 patients. | OnMedica
Abdomen blister and Cold agglutinin disease due to hiv and Tinnitus in children - Symptom Checker - check medical symptoms at...
Cold Agglutinin Disease Associated with Greater Than Twofold Increased Risk of Mortality in First Five Years After Diagnosis
...
A Study to Assess the Efficacy and Safety of BIVV009 in Participants With Primary Cold Agglutinin Disease Without A Recent...
A Study to Assess the Efficacy and Safety of BIVV009 (Sutimlimab) in Participants With Primary Cold Agglutinin Disease Without...
Our Stories | Cold Agglutinin Disease Foundation
Unusual manifestations of type II cryoglobulinaemia associated with Waldenströms macroglobulinaemia | Journal of Clinical...
What is the pathophysiology of warm-cold antibody combinations in cold agglutinin disease?
Joseph Sweeney John Reagan, Author at Oncology Nurse Advisor
肺炎支原體 - 维基百科,自由的百科全书
The CAD5 Study::Therapy for Chronic Cold Agglutinin Disease: A Prospective, Non-randomized International Multicenter Trial on...
Finger necrosis in cold agglutinin disease | British Society for Haematology
Hepatitis C virus infection, cryoglobulinaemia, and beyond | IRIS Univ. Bari
Laser Deposition of Cryoglobulin Blood Protein Thin Films by Matrix Assisted Pulsed Laser Evaporation
best vampire facial treatment reviews Sarasota FL 34243
| vampire facial for breasts Lakewood Ranch Florida
A reappraisal of the monoclonal rheumatoid factor test for circulating immune complexes: a comparison of two monoclonal...
Sabinet | Systemic lupus erythematosus associated with mixed cryoglobulinaemia and circulating anticoagulant
Eritropoietina ricombinante umana (RHuEpo) e fattore di crescita granulocitario (G-CSF) nella crioglobulinemia mista HCV...
Plus it
Patent US4540573 - Undenatured virus-free biologically active protein derivatives - Google Patents
Cryoglobulinemia - Therapeutics in Dermatology
Col14a1 MGI Mouse Gene Detail - MGI:1341272 - collagen, type XIV, alpha 1
Cold sensitive antibodies
Normally, no cryoglobulins should be found in the body. Cryoglobulins more than often do not interact with red blood cells, ... Cryoglobulins are abnormal antibodies that only dissolve/disappear at temperature higher than 37 °C (99 °F) and form solid or ... Therefore, cryoglobulins don't produce hemolysis effect, however its serious complications such as systemic inflammatory or ... At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of ...
Cryoglobulinemia
Signs and symptoms due to the cryoglobulins of type I disease reflect the hyperviscosity and deposition of cryoglobulins within ... The following sections of clinical features focuses on those attributed to the cryoglobulins. Cryoglobulins cause tissue damage ... Their cryoglobulins should be analyzed for their composition of immunoglobulin type(s) and complement component(s) and examined ... Cryoglobulins consists of one or more of the following components: monoclonal or polyclonal IgM, IgG, IgA antibodies, ...
Haemophilia
"High-potency Antihæmophilic Factor Concentrate prepared from Cryoglobulin Precipitate". Nature. 203 (4942): 312. Bibcode: ...
Waldenström's macroglobulinemia
Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive. Beta-2 ...
CD5L
1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated ...
Rheumatoid factor
... can also be a cryoglobulin (antibody that precipitates on cooling of a blood sample); it can be either type 2 ... monoclonal IgM to polyclonal IgG) or type 3 (polyclonal IgM to polyclonal IgG) cryoglobulin. Although predominantly encountered ...
Shunt nephritis
Levels of the complement protein C3 are low, while levels of C-reactive protein and cryoglobulins may be modestly elevated. ...
July 1964
The paper, "High Potency Antihemophiliac Concentrate Prepared from Cryoglobulin Precipitate", appeared in the 18 July issue of ...
Cryoglobulinemic vasculitis
... of people with detectable circulating cryoglobulin proteins. Additionally, the kidneys may be affected by this form of ... is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins in the ...
Nephrotic syndrome
... cryoglobulins, serum electrophoresis), or ultrasound of the whole abdomen. A broad classification of nephrotic syndrome based ...
List of MeSH codes (D12.776)
... cryoglobulins MeSH D12.776.377.715.548.900.500 - myeloma proteins MeSH D12.776.377.715.548.900.700 - pyroglobulins MeSH D12.776 ...
List of MeSH codes (D12.776.124)
... cryoglobulins MeSH D12.776.124.486.485.900.500 - myeloma proteins MeSH D12.776.124.486.485.900.700 - pyroglobulins MeSH D12.776 ... cryoglobulins MeSH D12.776.124.790.651.900.500 - myeloma proteins MeSH D12.776.124.790.651.900.700 - pyroglobulins MeSH D12.776 ...
Systemic vasculitis
Most often due to hepatitis C infection, immune complexes of cryoglobulins --- proteins that consists of immunoglobulins and ...
Plasma cell dyscrasias
Cryoglobulins are proteins, principally immunoglobulins, that circulate in the blood, precipitate at temperatures 5 gram/liter ...
Thrombocythemia
This is due to the presence of structures resembling platelets in the blood such as needle-like cryoglobulin crystals, ...
Cryoglobulins: MedlinePlus Medical Encyclopedia
Cryoglobulins are antibodies that become solid or gel-like at low temperatures in the laboratory. This article describes the ... Cryoglobulins come in three main types, but in 90% of cases, the cause is hepatitis C. The disease in which cryoglobulins are ... This test is most often done when a person has symptoms of a condition associated with cryoglobulins. Cryoglobulins are ... In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6°F (37°C). They ...
Cryoglobulin | blood protein | Britannica.com
... the blood of proteins called cryoglobulins that precipitate at temperatures below 98.6° F (37° C), both in the laboratory and ... the blood of proteins called cryoglobulins that precipitate at temperatures below 98.6° F (37° C), both in the laboratory and ... in the body (where the precipitation could cause circulatory impairment or blockage or sometimes hemorrhage). Cryoglobulinemia ... Other articles where Cryoglobulin is discussed: cryoglobulinemia: … ...
How does the presence of cryoglobulins help diagnose rheumatoid arthritis?
Cryoglobulins as Potential Triggers of Inflammation in Schizophrenia
No influence of cryoglobulins on production of IL-10 by PBMCs was observed. Also, it was shown that cryoglobulins in ... in IL-1β, IL-6, TNF-α, IL-8, and MCP-1 production by cultured PBMCs when incubating for 24 hours with cryoglobulins, beginning ... Cryoglobulins as Potential Triggers of Inflammation in Schizophrenia. Andranik Chavushyan, Meri Hovsepyan, and Anna Boyajyan ... This case study aimed to investigate effects of type III cryoglobulins isolated from the blood of patients with schizophrenia ...
Pathological serum protein (cryoglobulin) as nucleic acid-protein complex | SpringerLink
Cryoglobulins | definition of cryoglobulins by Medical dictionary
... cryoglobulins explanation free. What is cryoglobulins? Meaning of cryoglobulins medical term. What does cryoglobulins mean? ... Looking for online definition of cryoglobulins in the Medical Dictionary? ... cryoglobulins. Also found in: Dictionary, Encyclopedia.. Related to cryoglobulins: cryoglobulinemia. cry·o·glob·u·lins. (krīō- ... Q The beginning of our procedure for testing a blood sample for cryoglobulins calls for heating the drawtube at 37[degrees]C ...
Cryoglobulin, Qualitative with Reflex to Quantitative IgA, IgG, & IgM
Cryoglobulin - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Cryoglobulin. Does this test have other names?. Cryocrit, cryoprotein. What is this test?. This test is done to find out if you ... High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with a number of ... If your cryoglobulin test is positive, your healthcare provider will do more tests to find out the cause. ... A normal test is negative for cryoglobulins. This means the antibodies in your blood stay dissolved even when the blood is ...
Cryoglobulin - AHealthyMe - Blue Cross Blue Shield of Massachusetts
High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with a number of ... If your cryoglobulin test is positive, your healthcare provider will do more tests to find out the cause. ... A normal test is negative for cryoglobulins. This means the antibodies in your blood stay dissolved even when the blood is ... These abnormal blood proteins (cryoglobulins) are dissolved in your blood at the normal body temperature. But when you are in a ...
Cryoglobulins | Multimedia Encyclopedia | Health Information | St. Luke's Hospital
Cryoglobulins come in three main types, but in 90% of cases, the cause is hepatitis C . The disease in which cryoglobulins are ... This test is most often done when a person has symptoms of a condition associated with cryoglobulins. Cryoglobulins are ... In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6 degrees Fahrenheit ( ... Cryoglobulins are abnormal antibody proteins. This article describes the blood test used to check for them. ...
Cryoglobulin
High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with some ... These abnormal blood proteins (cryoglobulins) are dissolved in your blood at the normal body temperature. But when you are in a ... If you test positive for cryoglobulins, it means these proteins became visibly thickened when your blood sample was chilled. ... This test is done to find out if you have abnormal proteins called cryoglobulins in your blood. ...
Cryoglobulin serum - Things You Didn't Know
Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active...
Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ... Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ... Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ...
Laser Deposition of Cryoglobulin Blood Protein Thin Films by Matrix Assisted Pulsed Laser Evaporation
Cryoglobulins | Article about Cryoglobulins by The Free Dictionary
Find out information about Cryoglobulins. An abnormal protein, usually an immunoglobulin, which precipitates from plasma ... cryoglobulin. (redirected from Cryoglobulins). Also found in: Dictionary, Medical.. Related to Cryoglobulins: cryoglobulinemia ... Cryoglobulins , Article about Cryoglobulins by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Cryoglobulins ... The cryoglobulin count in her blood steadily decreased, and by April of this year it was undetectable.. Cancer? She thought so ...
KAKEN - Research Projects | Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection....
Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection.. Research Project ... cryoglobulin / cold activation (CA) / C型肝炎 / 補体寒冷活性化 / クリオグロブリン / リウマトイド因子 / コールドアクチベーション / HCV / 可溶性IL-2レセプター / 非ホジキンリンパ腫 / 質量 ... The complement may be activated by an immune complex formed at a low temperature and this may be related to cryoglobulin. The ... The association of complement activation at a low temperature with hepatitis C virus infection
Cryoglobulin | definition of cryoglobulin by Medical dictionary
... cryoglobulin explanation free. What is cryoglobulin? Meaning of cryoglobulin medical term. What does cryoglobulin mean? ... Looking for online definition of cryoglobulin in the Medical Dictionary? ... Related to cryoglobulin: cryofibrinogen, Cryoglobulin Test, cryoglobulinemia. cryoglobulin. [kri″o-glob´u-lin] a serum globulin ... Cryoglobulin , definition of cryoglobulin by Medical dictionary https://medical-dictionary.thefreedictionary.com/cryoglobulin ...
Cryoglobulin - South Tees Hospitals NHS Foundation Trust | South Tees Hospitals NHS Foundation Trust
Cryoglobulin Alternative name:. Description:. Cryoglobulins are immunoglobulins which reversibly precipitate in the cold. Type ... Cryoglobulin quantitated and may be analysed further by elctrophoresis.. Restrictions:. For cryoglobulin screen, routine SST ... cryoglobulins are associated with B-cell lymphoma and myeloma whilst mixed cryoglobulins (type II and III) are associated with ... For cryoglobulin assay, sample must be collected and transported at 37°C. Sample is centrifuged and serum collected. On arrival ...
AN ATYPICAL CASE OF AKI: WHEN CRYOGLOBULINS GO COLD - SHM Abstracts
AN ATYPICAL CASE OF AKI: WHEN CRYOGLOBULINS GO COLD. Hani Rashad Rashid, D.O.*1;Phuong Thy Nguyen, D.O.2;Roberto Collazo- ... Rashid, HR; Nguyen, PT; Collazo-Maldonado, R; Saleh, A . AN ATYPICAL CASE OF AKI: WHEN CRYOGLOBULINS GO COLD. Abstract ... caused by cryoglobulin-containing immune complex deposition and complement activation. Patients with type II (mixed) ... www.shmabstracts.com/abstract/an-atypical-case-of-aki-when-cryoglobulins-go-cold/. Accessed January 25, 2020. ...
Cryoglobulin
Cold sensitive antibodies - Wikipedia
Normally, no cryoglobulins should be found in the body. Cryoglobulins more than often do not interact with red blood cells, ... Cryoglobulins are abnormal antibodies that only dissolve/disappear at temperature higher than 37 °C (99 °F) and form solid or ... Therefore, cryoglobulins dont produce hemolysis effect, however its serious complications such as systemic inflammatory or ... At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of ...
Cryoglobulinemia - Wikipedia
Signs and symptoms due to the cryoglobulins of type I disease reflect the hyperviscosity and deposition of cryoglobulins within ... The following sections of clinical features focuses on those attributed to the cryoglobulins. Cryoglobulins cause tissue damage ... Their cryoglobulins should be analyzed for their composition of immunoglobulin type(s) and complement component(s) and examined ... Cryoglobulins consists of one or more of the following components: monoclonal or polyclonal IgM, IgG, IgA antibodies, ...
Crisis Core Final Fantasy VII
Crisis Core Final Fantasy VII
Crisis Core Final Fantasy VII
Crisis Core Final Fantasy VII
Crisis Core Final Fantasy VII
CryoglobulinemiaImmunoglobulinsAntibodiesImmuneVasculitisComplementImmunoglobulinAntibodyType III cryoglobulinsTypes of cryoglobulinsLevels of cryoglobulinsProduction of cryoglobulinsSerum cryoglobulinsPrecipitate at temperaturesPositive rheumatoid factorCold agglutininProteins in the bQualitativeChronicInfectionSystemic lupus erythemDetectableSymptomsTemperaturesMonoclonalPolyclonalPatientsImmunochemicalAbnormal bloodNegativeAssayCryofibrinogenRheumatoid arthritisEndocarditisBiologicalBloodMeasurementsAutoimmuneFibronectin
Cryoglobulinemia21
- Cryoglobulins come in three main types, but in 90% of cases, the cause is hepatitis C . The disease in which cryoglobulins are found is called cryoglobulinemia . (medlineplus.gov)
- Cryoglobulins are associated with cryoglobulinemia. (medlineplus.gov)
- l) Cryoglobulinemia is a condition in which the blood contains large amounts of cryoglobulins which are proteins that become insoluble at reduced temperatures. (thefreedictionary.com)
- 7,8) The paraprotein may also have autoantibody or cryoglobulin activity resulting in autoimmune phenomena or cryoglobulinemia. (thefreedictionary.com)
- The term "cryoglobulinemia" is commonly used to describe patients with a systemic inflammatory syndrome that is often associated with small-to-medium vessel vasculitis due to cryoglobulin-containing immune complexes. (pearls4peers.com)
- BACKGROUND: Human cryoglobulinemia is sometimes associated with glomerulonephritis (GN) due to deposition of cryoglobulins (cryos). (elsevier.com)
- At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of hepatitis C. The presence of cryoglubulins in body satisfies the criterion of the diagnosis of cryoglobulinemia, a disease that inflame the blood vessels and organs like kidney, nerves, joints, lungs and skin. (wikipedia.org)
- Cryoglobulinemia is a medical condition in which the blood contains large amounts of pathological cold sensitive antibodies called cryoglobulins - proteins (mostly immunoglobulins themselves) that become insoluble at reduced temperatures. (wikipedia.org)
- While this disease is commonly referred to as cryoglobulinemia in the medical literature, it is better termed cryoglobulinemic disease for two reasons: 1) cryoglobulinemia is also used to indicate the circulation of (usually low levels of) cryoglobulins in the absence of any symptoms or disease and 2) healthy individuals can develop transient asymptomatic cryoglobulinemia following certain infections. (wikipedia.org)
- Cryoglobulinemia is characterized by the presence of cryoglobulins in the serum. (medscape.com)
- Types II and III cryoglobulinemia represent 80% of all cryoglobulins. (medscape.com)
- Cryoglobulinemia is a medical condition that is caused by proteins called cryoglobulins, which are present in the blood. (medicinenet.com)
- Cryoglobulins can accompany another condition (such as dermatomyositis , multiple myeloma , viral infections, or lymphoma ) or be an isolated condition themselves, called cryoglobulinemia. (medicinenet.com)
- Cryoglobulins in the blood (cryoglobulinemia) can cause a variety of problems throughout the body. (medicinenet.com)
- When the cryoglobulin proteins are a mixture of various antibody types, and forming for unknown reasons (essential), the conditions is referred to as essential mixed cryoglobulinemia. (medicinenet.com)
- Mixed cryoglobulinemia is a rare disorder characterized by the presence of cryoglobulins in the blood. (rarediseases.org)
- In type I cryoglobulinemia, cryoglobulins are made up of a specific immunoglobulin, usually IgM. (rarediseases.org)
- Unlike type I cryoglobulinemia, the cryoglobulins in type II and type III contain rheumatoid factor, which is an autoantibody (i.e. an antibody that attacks the body own tissue). (rarediseases.org)
- To investigate the prevalence of mixed cryoglobulinemia in patients with HIV-1 infection, the clinical spectrum of cryoglobulinemia in these patients, and the possible role of HIV-1 in cryoglobulin formation. (annals.org)
- Nine cryoglobulin-positive patients (38% [CI, 19% to 54%]) had clinical manifestations compatible with cryoglobulinemia. (annals.org)
- Cryoglobulinemia refers to a condition with circulating cryoglobulins in the serum. (psychiatryadvisor.com)
Immunoglobulins9
- In this syndrome, cryoglobulins composed of HCV immune complexes, immunoglobulins, rheumatoid factor, and complement are deposited in tissues. (thefreedictionary.com)
- Cryoglobulins are immunoglobulins that undergo reversible precipitation at low temperatures. (thefreedictionary.com)
- Cryoglobulins are immunoglobulins which reversibly precipitate in the cold. (southtees.nhs.uk)
- Rarely, it is associated with precipitation of the immunoglobulins in vivo during very cold weather causing severe vasculitis.Unless samples to be tested for cryoglobulins are kept at 37°C from venepuncture until they are received in the laboratory the results may be meaningless. (southtees.nhs.uk)
- INTRODUCTION Cryoglobulins are abnormal immune complexes where both the antigens and the antibodies are immunoglobulins. (scienceexchange.com)
- The proteolytic fragments of native fibronectin (cryopeptides) complexed to pathological immunoglobulins in cryoglobulins were isolated from the serum of six different patients. (ox.ac.uk)
- The classification distinguishes three subtypes of cryoglobulinemic diseases based on two factors, the class of immunoglobulins in the cryoglobulin and the association of the cryoglobulinemic disease with other disorder. (wikipedia.org)
- More recent high resolution protein electrophoresis methods have detected a small monoclonal immunoglobulin component in type III cryoglobulins and/or a micro-heterogeneous composition of oligo-clonal (i.e., more than one monoclonal) immunoglobulin components or immunoglobulins with structures that do not fit into any classifications in the cryoglobulins of ≈10% of type II and III disease cases. (wikipedia.org)
- It thereby potentially lowers the activation threshold of B lymphocytes, lead to B-cell clonal expansion, overproduction of immunoglobulins and ultimately formation of cryoglobulins (by mechanisms not clearly understood yet). (psychiatryadvisor.com)
Antibodies9
- Cryoglobulins are antibodies that become solid or gel-like at low temperatures in the laboratory. (medlineplus.gov)
- Cryoglobulins are antibodies that may be high in people who have a variety of different diseases, including rheumatoid arthritis, lupus, Sjögren's syndrome, Waldenstrom's macroglobulinemia, multiple myeloma, lymphoproliferative disorders, hepatitis B and C, and other infections. (webmd.com)
- In viral infections (HCV, CMV, HIV), development of TTP seems to be linked to immune phenomena such as the presence of cryoglobulins and anticardiolipin antibodies as well as endothelial damage [7]. (thefreedictionary.com)
- Cryoglobulins in chronic hepatitis C patients are cryoprecipitable immune complexes that contain IgM rheumatoid factor (IgM anti-IgG), HCV-RNA and core proteins associated with the IgG antibodies that are produced during the immune response of B-cells against HCV antigens. (thefreedictionary.com)
- Anticardiolipin auto antibodies in serum samples and cryoglobulins of patients with chronic hepatitis C infection. (thefreedictionary.com)
- Such patients have multiple serological abnormalities like anticardiolipin antibodies, cryoglobulins , and hypocomplementemia. (thefreedictionary.com)
- These pathological cold sensitive antibodies include cold agglutinins, Donath-Landsteniner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath-Landsteiner hemolytic anemia, and vasculitis, respectively. (wikipedia.org)
- Cryoglobulins are abnormal antibodies that only dissolve/disappear at temperature higher than 37 °C (99 °F) and form solid or gel-like immune complexes in presence of the environment under 37 °C (99 °F), which can block blood vessels and cause a variety of health problems including inflammation and organ damage. (wikipedia.org)
- Serum and cryoglobulins were evaluated for antibodies to HIV and hepatitis C virus (HCV), HIV-1, and HCV viral load. (annals.org)
Immune7
- Based upon the results obtained, we concluded that type III cryoglobulins are implicated in schizophrenia-associated alterations in the immune response through induction of the expression of proinflammatory and chemotactic cytokines by PBMCs. (hindawi.com)
- The complement may be activated by an immune complex formed at a low temperature and this may be related to cryoglobulin. (nii.ac.jp)
- This may result in a clinical syndrome of systemic inflammation and tissue damage (commonly affecting the kidneys and skin) caused by cryoglobulin-containing immune complex deposition and complement activation. (shmabstracts.com)
- The vascular deposition of these types of cryoglobulin-containing immune complexes and complement can cause a clinical syndrome of cutaneous small-vessel vasculitis characterized by systemic vasculitis and inflammation termed cryoglobulinemic vasculitis. (wikipedia.org)
- Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. (elsevier.com)
- [ 11 , 12 ] The ratio of antibody to antigen in circulating cryoglobulin aggregates or immune complexes affects the rate of clearance from the circulation and the resultant rate and location of tissue deposition. (medscape.com)
- In these disorders, cryoglobulins are abnormal immune complexes. (rarediseases.org)
Vasculitis9
- Cryoglobulins can cause inflammation in blood vessels, called vasculitis. (medlineplus.gov)
- Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis. (ox.ac.uk)
- The host genetic basis of mixed cryoglobulin vasculitis is not well understood and has not been studied in large cohorts. (ox.ac.uk)
- A genome-wide association study was conducted among 356 hepatitis C virus (HCV) RNA-positive individuals with cryoglobulin-related vasculitis and 447 ethnically matched, HCV RNA-positive controls. (ox.ac.uk)
- All cases had both serum cryoglobulins and a vasculitis syndrome. (ox.ac.uk)
- A genome-wide significant association with cryoglobulin-related vasculitis was identified with SNPs near NOTCH4 and MHC Class II genes. (ox.ac.uk)
- There is a higher risk for lymphoma and early death when Sjögren syndrome has been very active for a long time, as well as in people with vasculitis, low complements, and cryoglobulins. (medlineplus.gov)
- The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. (elsevier.com)
- Although the cause of cryoglobulinemic vasculitis is not known, a critical component is the presence of cryoglobulins-abnormal proteins that white blood cells called B lymphocytes produce in response to the chronic hepatitis C infection. (clinicaltrials.gov)
Complement5
- Further tests to assist with the diagnosis include antinuclear antibody profile, antineutrophil cytoplasmic antibody, C-reactive protein, cryoglobulins , serum complement, hepatitis B and C profile, HIV, venereal disease research laboratory test and uric acid levels. (thefreedictionary.com)
- Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection. (nii.ac.jp)
- The ability of cryoglobulins to bind C-reactive protein and low density lipoproteins, activate complement, and stimulate production of tumor necrosis factor-alpha generates interest in studying cryoglobulins in ischemic stroke. (scienceexchange.com)
- DISCUSSION Determination of immunoglobulin (Ig) content of cryoglobulins revealed the presence of a mixture of polyclonal IgG, IgA, and IgM, C3 complement protein and its activation split products, C1q complement protein, pathogenic lipoprotein-X, and beta-lipoprotein. (scienceexchange.com)
- CONCLUSION We suggest that cryoglobulins are involved in post-ischemic inflammatory response through activation of the complement cascade and cytokines production. (scienceexchange.com)
Immunoglobulin4
- As such, requests for cryoglobulins will initially be tested for C4, immunoglobulin levels (including electrophoresis) and rheumatoid factor using a routine SST sample. (southtees.nhs.uk)
- The following table lists these three types of cryoglobulinemic disease, characterized on the monoclonal immunoglobulin(s) comprising the involved cryoglobulin, percentage of total cryoglobulinemic disease cases, and class of disorders associated for each type. (wikipedia.org)
- The solubility of cryoglobulins has been found to be partially related to the structure of component immunoglobulin heavy and light chains. (medscape.com)
- Cryoglobulins (CG) are immunoglobulin (Ig) complexes that precipitate from the serum at blood temperatures below 37°C and redissolve on rewarming. (psychiatryadvisor.com)
Antibody3
- Cryoglobulins are abnormal antibody proteins. (stlukes-stl.com)
- This patient's recent weight loss was concerning for underlying systemic disease, so a laboratory work-up including complete blood count, serum protein electrophoresis, cold agglutinins, antinuclear antibody, rheumatoid factor, and cryoglobulins was performed. (thefreedictionary.com)
- The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HCV genotype was determined by polymerase chain reaction with genotype specific primer. (bmj.com)
Type III cryoglobulins2
- This case study aimed to investigate effects of type III cryoglobulins isolated from the blood of patients with schizophrenia on the production of proinflammatory cytokines interleukin(IL)-1 β , IL-6 and tumor necrosis factor- α (TNF- α ), anti-inflammatory cytokine IL-10, and chemotactic cytokines IL-8 and monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cells (PBMCs). (hindawi.com)
- Type II and Type III cryoglobulins exhibit rheumatoid factor activity and are invariably associated with marked consumption of C4. (southtees.nhs.uk)
Types of cryoglobulins1
- Several types of cryoglobulins have been identified, and the potential clinical manifestations vary by cryoglobulin type. (medscape.com)
Levels of cryoglobulins4
- High levels of cryoglobulins may be a sign that your body is making abnormal proteins. (ahealthyme.com)
- High circulating levels of cryoglobulins can arise in the setting of hepatitis C infection, but can also be seen in a number of autoimmune disorders and other infectious diseases. (thefreedictionary.com)
- MATERIALS AND METHODS We determined blood levels of cryoglobulins in patients with ischemic stroke at different time points of stroke onset and identified the composition of cryoglobulins isolated from the blood on the first day of stroke onset. (scienceexchange.com)
- RESULTS On days 1-14, significantly elevated levels of cryoglobulins were detected with the maximum level on day 3. (scienceexchange.com)
Production of cryoglobulins2
- Currently most cases of this disease are found to be associated with premalignant, malignant, infectious, or autoimmune disorders that are the known or presumed causes for the production of cryoglobulins. (wikipedia.org)
- Besides viral infection itself, multiple factors appear to be responsible for the production of cryoglobulins, including cirrhosis and duration of liver disease. (nih.gov)
Serum cryoglobulins1
- How should I interpret a positive result for serum cryoglobulins? (pearls4peers.com)
Precipitate at temperatures1
- the blood of proteins called cryoglobulins that precipitate at temperatures below 98.6° F (37° C), both in the laboratory and in the body (where the precipitation could cause circulatory impairment or blockage or sometimes hemorrhage). (britannica.com)
Positive rheumatoid factor1
- Most patients with type II or III cryoglobulins have a positive rheumatoid factor. (nephronpower.com)
Cold agglutinin3
- Cryoglobulins more than often do not interact with red blood cells, unless it combines the features of cold agglutinin with cryoglobulins, although the chance is deemed rare. (wikipedia.org)
- A purified human monoclonal IgM(κ) (cold agglutinin MKV) has been characterized as both a cold agglutinin and a cryoglobulin. (elsevier.com)
- Tsai, CM, Zopf, DA & Yu, RK 1977, ' A Waldenstrom macroglobulin that is both a cold agglutinin and a cryoglobulin because it binds N-acetylneuraminosyl residues ', Proceedings of the National Academy of Sciences of the United States of America , vol. 74, no. 10, pp. 4591-4594. (elsevier.com)
Proteins in the b1
- Cryoglobulins are abnormal proteins in the blood. (mayoclinic.org)
Qualitative2
- Cryoglobulin, qualitative - serum. (medlineplus.gov)
- If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. (aruplab.com)
Chronic1
- Cryoglobulins are associated with chronic infections. (annals.org)
Infection4
- Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infection. (thefreedictionary.com)
- Cryoglobulins are often found in association with collagen-vascular diseases, lymphoproliferative diseases, and several infectious diseases including HCV infection. (bmj.com)
- 10-15 But the prevalence and clinical significance of cryoglobulin remain unclear in patients with HCV infection. (bmj.com)
- Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease. (aruplab.com)
Systemic lupus erythem1
- Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active systemic lupus erythematosus. (bmj.com)
Detectable2
- Symptomatic MC has been observed in up to 21 percent of patients with HCV, and the percentage of HCV patients with detectable cryoglobulins may be as high as 54 percent [29]. (thefreedictionary.com)
- one of these also had detectable cryoglobulins. (cdc.gov)
Symptoms5
- This test is most often done when a person has symptoms of a condition associated with cryoglobulins. (medlineplus.gov)
- Many people affected by cryoglobulins will not experience any unusual signs or symptoms. (wikipedia.org)
- In contrast to these benign instances of circulating cryoglobulins, cryoglobulinemic disease involves the signs and symptoms of precipitating cryoglobulins and is commonly associated with various pre-malignant, malignant, infectious, or autoimmune diseases that are the underlying cause for production of the cryoglobulins. (wikipedia.org)
- Plasmapheresis ( hemapheresis ), a procedure whereby the blood's serum is filtered to remove the cryoglobulins, is also performed for severe symptoms. (medicinenet.com)
- Testing for cryoglobulin is done when a person has symptoms of this protein or is being evaluated for one of the associated diseases. (stateuniversity.com)
Temperatures3
- Cryoglobulins typically precipitate (clumps together) at temperatures below normal body temperature - 37 degrees Celsius (99 degrees Fahrenheit) - and will dissolve again if the blood is heated. (wikipedia.org)
- Cryoglobulin clumps in cold temperatures. (stateuniversity.com)
- Cryoglobulins are abnormal proteins that thicken and clump together at cold temperatures, usually below 98.6 degrees Fahrenheit (the average human body temperature). (rarediseases.org)
Monoclonal3
- Type I (monoclonal) cryoglobulins are associated with B-cell lymphoma and myeloma whilst mixed cryoglobulins (type II and III) are associated with infective and inflammatory disorders. (southtees.nhs.uk)
- Type I cryoglobulins are usually monoclonal IgM or IgG proteins, Cryoglobulinaemia is usually a laboratory finding. (southtees.nhs.uk)
- Type I monoclonal CryoVas was characterized by severe cutaneous involvement (necrosis and ulcers) in almost 50% the patients, as well as high serum cryoglobulin levels. (medscape.com)
Polyclonal1
- The results indicate that cryoglobulin recognition of viral polypeptides is both polyclonal and multispecific. (elsevier.com)
Patients3
- However in patients lacking cryoglobulin , demyelinating PN dominate (23,24). (thefreedictionary.com)
- The HIV-1 viral load was higher in cryoglobulin-positive patients (median, 38.25 × 10 3 copies/mL [25th, 75th percentiles: 13.8 × 10 3 copies/mL, 78.55 × 10 3 copies/mL]) than in cryoglobulin-negative patients (median, 5.3 × 10 3 copies/mL [25th, 75th percentiles: 0.7 × 10 3 copies/mL, 27.2 × 10 3 copies/mL]) ( P = 0.001). (annals.org)
- Cryoglobulins became undetectable in 21 of 43 patients treated with interferon. (nih.gov)
Immunochemical2
- Immunochemical composition of cryoglobulins generated in stroke. (scienceexchange.com)
- Immunochemical characterisation of cryoglobulins. (bvsalud.org)
Abnormal blood2
- These abnormal blood proteins (cryoglobulins) are dissolved in your blood at the normal body temperature. (ahealthyme.com)
- Cryoglobulin is an abnormal blood protein associated with several diseases. (stateuniversity.com)
Negative3
- A normal test is negative for cryoglobulins. (ahealthyme.com)
- Cryoglobulin was negative, and protein electrophoresis was normal. (thefreedictionary.com)
- Cryoglobulins were negative. (hindawi.com)
Assay2
- Also order a viral screen and a cryoglobulins assay, Dr. (thefreedictionary.com)
- For cryoglobulin assay, sample must be collected and transported at 37°C. Sample is centrifuged and serum collected. (southtees.nhs.uk)
Cryofibrinogen2
- The laboratory will then arrange for samples for cryoglobulin determination to be collected appropriately.Other cryoprecipitates can include cold agglutinins which are IgMs associated with certain infections e.g mycoplasma, listeria, rickettsia or EBV or cryofibrinogen (rarely). (southtees.nhs.uk)
- It should be noted that cryoglobulins are distinct from cryofibrinogen which results from cryoprecipitation of frozen plasma and consists of fibrin, fibrinogen, fibronectin and fibrin split products. (psychiatryadvisor.com)
Rheumatoid arthritis1
- How does the presence of cryoglobulins help diagnose rheumatoid arthritis? (webmd.com)
Endocarditis1
- Cryoglobulins in infective endocarditis: correlation with organ involvement. (bvsalud.org)
Biological1
- Biological and clinical significance of cryoglobulins: a report of 86 cases. (springer.com)
Blood6
- In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6°F (37°C). They dissolve again when the sample is warmed up. (medlineplus.gov)
- Q The beginning of our procedure for testing a blood sample for cryoglobulins calls for heating the drawtube at 37[degrees]C for at least one hour. (thefreedictionary.com)
- This test is done to find out if you have abnormal proteins called cryoglobulins in your blood. (ahealthyme.com)
- If you test positive for cryoglobulins, it means these proteins became visibly sludge-like when your blood sample was refrigerated. (ahealthyme.com)
- In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6 degrees Fahrenheit (37 degrees Celsius). (stlukes-stl.com)
- The cryoglobulin count in her blood steadily decreased, and by April of this year it was undetectable. (thefreedictionary.com)
Measurements1
- In addition, M-proteins, especially those that are also cryoglobulins , can precipitate and cause erroneous measurements via several methods (1). (thefreedictionary.com)
Autoimmune1
- The clinical features of cryoglobulinemic disease can reflect those due not only to the circulation of cryoglobulins but also to any underlying hematological premalignant or malignant disorder, infectious disease, or autoimmune syndrome. (wikipedia.org)
Fibronectin1
- Modulation of human neutrophil function by fibronectin degradation products isolated from cryoglobulins. (ox.ac.uk)