Cryoglobulins. Medical search

Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.

A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.

A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.

Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.

Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. They are enzymes in the various COMPLEMENT ACTIVATION pathways.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.

A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.

A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.

Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.

INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.

Inflammation of any part of the KIDNEY.

Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

Facilities equipped to carry out investigative procedures.

Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.

An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.

Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.

Serum globulins with high molecular weight. (Dorland, 28th ed)

A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.

Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.

Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.

A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.

Organic-inorganic hybrid polymers developed primarily for DENTAL RESTORATION. They typically contain a defined mixture of ORGANOSILICON COMPOUNDS; CERAMICS; and organic POLYMERS.

Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.

An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.

Complement receptor 1 (CD35) on human reticulocytes: normal expression in systemic lupus erythematosus and HIV-infected patients. (1/235)

The low levels of complement receptor 1 (CR1) on erythrocytes in autoimmune diseases and AIDS may be due to accelerated loss in the circulation, or to a diminished expression of CR1 on the red cell lineage. Therefore, we analyzed the expression of CR1 on reticulocytes (R) vs erythrocytes (E). Healthy subjects had a significant higher CR1 number per cell on R (919 +/- 99 CR1/cell) than on E (279 +/- 30 CR1/cell, n = 23), which corresponded to a 3. 5- +/- 1.3-fold loss of CR1. This intravascular loss was confirmed by FACS analysis, which showed that all R expressed CR1, whereas a large fraction of E was negative. The systemic lupus erythematosus (SLE), HIV-infected, and cold hemolytic Ab disease (CHAD) patients had a CR1 number on R identical to the healthy subjects, contrasting with a lower CR1 on their E. The data indicated a significantly higher loss of CR1 in the three diseases, i.e., 7.0- +/- 3.8-, 6.1- +/- 2.9-, and 9.6- +/- 5.6-fold, respectively. The intravascular loss was best exemplified in a patient with factor I deficiency whose CR1 dropped from 520 CR1/R to 28 CR1/E, i.e., 18.6-fold loss. In one SLE patient and in the factor I-deficient patient, the FACS data were consistent with a loss of CR1 already on some R. In conclusion, CR1 is lost progressively from normal E during in vivo aging so that old E are almost devoid of CR1. The low CR1 of RBC in autoimmune diseases and HIV-infection is due to a loss occurring in the circulation by an active process that remains to be defined. (+info)

Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports. (2/235)

OBJECTIVE: To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN: Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING: Hospitals in United Kingdom and Ireland. SUBJECTS: Patients who died or experienced serious complications, as defined below, associated with transfusion of red cells, platelets, fresh frozen plasma, or cryoprecipitate. MAIN OUTCOME MEASURES: Death, "wrong" blood transfused to patient, acute and delayed transfusion reactions, transfusion related acute lung injury, transfusion associated graft versus host disease, post-transfusion purpura, and infection transmitted by transfusion. Circumstances relating to these cases and relative frequency of complications. RESULTS: Over 24 months, 366 cases were reported, of which 191 (52%) were "wrong blood to patient" episodes. Analysis of these revealed multiple errors of identification, often beginning when blood was collected from the blood bank. There were 22 deaths from all causes, including three from ABO incompatibility. There were 12 infections: four bacterial (one fatal), seven viral, and one fatal case of malaria. During the second 12 months, 164/424 hospitals (39%) submitted a "nil to report" return. CONCLUSIONS: Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient. Staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood. (+info)

Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. (3/235)

In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of the classical complement pathway with deposition of C3 is pathogenic in lupus nephritis. Although the alternative complement pathway is activated in lupus nephritis, its role in disease pathogenesis is unknown. To determine the role of the alternative pathway in lupus nephritis, complement factor B-deficient mice were backcrossed to MRL/lpr mice. MRL/lpr mice develop a spontaneous lupus-like disease characterized by immune complex glomerulonephritis. We derived complement factor B wild-type (B+/+), homozygous knockout (B-/-), and heterozygous (B+/-) MRL/lpr mice. Compared with B+/- or B+/+ mice, MRL/lpr B-/- mice developed significantly less proteinuria, less glomerular IgG deposition, and decreased renal scores as well as lower IgG3 cryoglobulin production and vasculitis. Serum C3 levels were normal in the B-/- mice compared with significantly decreased levels in the other two groups. These results suggest that: 1) factor B plays an important role in the pathogenesis of glomerulonephritis and vasculitis in MRL/lpr mice; and 2) activation of the alternative pathway, either by the amplification loop or by IgA immune complexes, has a prominent effect on serum C3 levels in this lupus model. (+info)

Cytoplasmic inclusions in leukocytes. An unusual manifestation of cryoglobulinemia. (4/235)

Cryoglobulins are circulating immunoglobulins characterized by reversible, cold-induced precipitation. A variety of laboratory abnormalities, including hypocomplementemia, elevated erythrocyte sedimentation rate, rheumatoid factor activity, pseudoleukocytosis, and pseudothrombocytosis, are associated with cryoglobulinemia. Extracellular, faintly basophilic, amorphous deposits of cryoglobulins occasionally have been described in blood smears. In the present study, smears prepared from blood collected at room temperature from 6 patients with cryoglobulinemia exhibited neutrophil and, occasionally, monocyte inclusions containing clear, light pink, or faintly basophilic amorphous material. The inclusions were absent in smears from blood collected and maintained at 37 degrees C. Ultrastructural examination revealed that the material within the leukocyte inclusions was consistent with phagocytosed immunoglobulins. The identification of characteristic cytoplasmic inclusions in leukocytes may be an important clue in the early recognition of cryoglobulinemia. (+info)

Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. (5/235)

The distribution on the cell surface of the large external LETS protein that is transformation sensitive of normal, transformed and tumorigenic cells was examined by immunofluorescent staining. A correlation was established between the expression of fibril-like LETS protein and the oncogenic capabilities of a series of adenovirus-transformed cell lines. In cells expressing a transformed phenotype in vitro, LETS protein is only detected in cell-cell contact areas, wheras in "untransformed" cells LETS protein is distributed over the cell surface. Transformed cells capable of inducing invasive tumors, and the cells of established tumor lines, have low or undetectable levels of LETS protein, as measured by this method. The results indicate that LETS protein has a role in cell-cell adhesion and that reduced expression of this protein at the cell surface is related to the oncogenic phenotype. This relationship has been established for experimentally induced and spontaneous tumors. (+info)

Complement fixation by rheumatoid factor. (6/235)

The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantly reduce the level of total hemolytic complement, CH50, or of individual complement components, C1, C2, C3, and C5. However, sheep erythrocytes (SRC) coated with Agg-R/A-IgG or with reduced and alkylated rabbit IgG anti-SRC antibody were hemolyzed by complement in the presence of polyclonal IgM-RF. Human and guinea pig complement worked equally well. The degree of hemolysis was in direct proportion to the hemagglutination titer of the RF against the same coated cells. Monoclonal IgM-RF, normal human IgM, and purified Waldenstrom macroglobulins without antiglobulin activity were all inert. Hemolysis of coated SRC by RF and complement was inhibited by prior treatment of the complement source with chelating agents, hydrazine, cobra venom factor, specific antisera to C1q, CR, C5, C6, or C8, or by heating at 56 degrees C for 30 min. Purified radiolabeled C4, C3, and C8 included in the complement source were bound to hemolysed SRC in direct proportion to the degree of hemolysis. These data indicate that polyclonal IgM-RF fix and activate complement via the classic pathway. The system described for assessing complement fixation by isolated RF is readily adaptable to use with whole human serum. (+info)

Cryofibrinogenaemia: a study of 49 patients. (7/235)

The purpose of this study was to characterize the clinical features and components of 30 patients with isolated cryofibrinogen (CF) versus those of 19 patients with combined CF and cryoglobulins (CG). Secondary forms of cryofibrinogenaemia associated with collagen disorders, infectious or malignant diseases, were significantly more frequent in patients with combined CF and CG than those with isolated CF (79 versus 47%, P = 0.02). Both groups of CF patients presented predominantly cutaneous symptoms (77% in isolated CF; 58% in combined CF + CG), and less frequently venous and/or arterial thrombosis (13% in isolated CF; 3% in combined CF + CG). Patients with idiopathic forms of CF, and particularly those without CG, suffered essentially from recurrent painful skin ulcers, mainly triggered by cold exposure. Patients with isolated CF had higher mean plasma concentrations of CF than those with combined CF + CG (1. 61 +/- 1.26 versus 0.82 +/- 1.18 g/l, respectively; P = 0.004), but there was no correlation between the CF plasma level and either the severity of symptoms or the sensitivity to cold. In patients with isolated CF, fibronectin was suggested (by precipitation analysis) to be a major component of the cryoprecipitate, whereas immunoglobulins were rarely present (in only three out of 30 patients). By contrast, in the majority of patients (78%) with combined CF and CG, the CF consisted mainly of immunoglobulins of the same class as those characterizing the associated CG. Analysis of the CG precipitate revealed the presence of fibronectin but not fibrinogen, alpha1-antitrypsin and alpha2-macroglobulin. In conclusion, isolated and combined cryofibrinogenaemia are associated with different clinical signs requiring different clinical management, but there is no evidence as yet for a causal role of the cryoprecipitates in the differences observed. (+info)

Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus. (8/235)

Although the association of cryoglobulinemia with hypocomplementemia and tissue injury in systemic lupus erythematosus is well recognized, composition of cryoprecipitates in terms of circulating antigens and antibodies in this disease is less clear. To clarify this question, cryoprecipitates from patients with SLE were examined with sensitive assay techniques for certain antipolynucleotide antibodies and DNA antigen. DNA antibodies were highly enriched relative to serum levels in the majority of cryoprecipitates. DNA antigen was also demonstrable. Antibody to ribonucleoprotein, although less frequently present, was similarly enriched in certain cryoprecipitates. In contrast, anti-double strand RNA, which was commonly detectable in relatively high titer in serum, was only minimally concentrated in a minority of cryoprecipitates. Absorption experiments using red blood cells heavily coated with polynucleotide antigen indicated that a major proportion of the IgG in certain cryoprecipitates was specific antibody. The data strongly suggest that the cryoprecipitates in systemic lupus erythematosus represent circulating immune complexes that are soluble at 37 degrees C and come out of solution in the cold. The marked concentration of immune complexes in the cryoglobulin offers a simple and direct method for determination of the nature of the complexes. The accumulated evidence obtained in the present study indicates that these complexes closely reflect, in their composition, the circulating immune complexes which are most significant pathogenetically in renal tissue injury. (+info)

Normally, no cryoglobulins should be found in the body. Cryoglobulins more than often do not interact with red blood cells, ... Cryoglobulins are abnormal antibodies that only dissolve/disappear at temperature higher than 37 °C (99 °F) and form solid or ... Therefore, cryoglobulins don't produce hemolysis effect, however its serious complications such as systemic inflammatory or ... At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of ...

https://en.wikipedia.org/wiki/Cold_sensitive_antibodies

Signs and symptoms due to the cryoglobulins of type I disease reflect the hyperviscosity and deposition of cryoglobulins within ... The following sections of clinical features focuses on those attributed to the cryoglobulins. Cryoglobulins cause tissue damage ... Their cryoglobulins should be analyzed for their composition of immunoglobulin type(s) and complement component(s) and examined ... Cryoglobulins consists of one or more of the following components: monoclonal or polyclonal IgM, IgG, IgA antibodies, ...

https://en.wikipedia.org/wiki/Cryoglobulinemia

"High-potency Antihæmophilic Factor Concentrate prepared from Cryoglobulin Precipitate". Nature. 203 (4942): 312. Bibcode: ...

https://en.wikipedia.org/wiki/Haemophilia

Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive. Beta-2 ...

https://en.wikipedia.org/wiki/Waldenström's_macroglobulinemia

1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated ...

https://en.wikipedia.org/wiki/CD5L

... can also be a cryoglobulin (antibody that precipitates on cooling of a blood sample); it can be either type 2 ... monoclonal IgM to polyclonal IgG) or type 3 (polyclonal IgM to polyclonal IgG) cryoglobulin. Although predominantly encountered ...

https://en.wikipedia.org/wiki/Rheumatoid_factor

Levels of the complement protein C3 are low, while levels of C-reactive protein and cryoglobulins may be modestly elevated. ...

https://en.wikipedia.org/wiki/Shunt_nephritis

The paper, "High Potency Antihemophiliac Concentrate Prepared from Cryoglobulin Precipitate", appeared in the 18 July issue of ...

https://en.wikipedia.org/wiki/July_1964

... of people with detectable circulating cryoglobulin proteins. Additionally, the kidneys may be affected by this form of ... is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins in the ...

https://en.wikipedia.org/wiki/Cryoglobulinemic_vasculitis

... cryoglobulins, serum electrophoresis), or ultrasound of the whole abdomen. A broad classification of nephrotic syndrome based ...

https://en.wikipedia.org/wiki/Nephrotic_syndrome

... cryoglobulins MeSH D12.776.377.715.548.900.500 - myeloma proteins MeSH D12.776.377.715.548.900.700 - pyroglobulins MeSH D12.776 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

... cryoglobulins MeSH D12.776.124.486.485.900.500 - myeloma proteins MeSH D12.776.124.486.485.900.700 - pyroglobulins MeSH D12.776 ... cryoglobulins MeSH D12.776.124.790.651.900.500 - myeloma proteins MeSH D12.776.124.790.651.900.700 - pyroglobulins MeSH D12.776 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)

Most often due to hepatitis C infection, immune complexes of cryoglobulins --- proteins that consists of immunoglobulins and ...

https://en.wikipedia.org/wiki/Systemic_vasculitis

Cryoglobulins are proteins, principally immunoglobulins, that circulate in the blood, precipitate at temperatures 5 gram/liter ...

https://en.wikipedia.org/wiki/Plasma_cell_dyscrasias

This is due to the presence of structures resembling platelets in the blood such as needle-like cryoglobulin crystals, ...

https://en.wikipedia.org/wiki/Thrombocythemia

Cryoglobulins are antibodies that become solid or gel-like at low temperatures in the laboratory. This article describes the ... Cryoglobulins come in three main types, but in 90% of cases, the cause is hepatitis C. The disease in which cryoglobulins are ... This test is most often done when a person has symptoms of a condition associated with cryoglobulins. Cryoglobulins are ... In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6°F (37°C). They ...

https://medlineplus.gov/ency/article/003555.htm

... the blood of proteins called cryoglobulins that precipitate at temperatures below 98.6° F (37° C), both in the laboratory and ... the blood of proteins called cryoglobulins that precipitate at temperatures below 98.6° F (37° C), both in the laboratory and ... in the body (where the precipitation could cause circulatory impairment or blockage or sometimes hemorrhage). Cryoglobulinemia ... Other articles where Cryoglobulin is discussed: cryoglobulinemia: … ...

https://www.britannica.com/science/cryoglobulin

cryoglobulins are antibodies that may be high in people who have a variety of different diseases, including rheumatoid ... How does the presence of cryoglobulins help diagnose rheumatoid arthritis?. ANSWER Cryoglobulins are antibodies that may be ...

https://www.webmd.com/osteoarthritis/qa/how-does-the-presence-of-cryoglobulins-help-diagnose-rheumatoid-arthritis

No influence of cryoglobulins on production of IL-10 by PBMCs was observed. Also, it was shown that cryoglobulins in ... in IL-1β, IL-6, TNF-α, IL-8, and MCP-1 production by cultured PBMCs when incubating for 24 hours with cryoglobulins, beginning ... Cryoglobulins as Potential Triggers of Inflammation in Schizophrenia. Andranik Chavushyan, Meri Hovsepyan, and Anna Boyajyan ... This case study aimed to investigate effects of type III cryoglobulins isolated from the blood of patients with schizophrenia ...

https://www.hindawi.com/journals/schizort/2013/125264/abs/

Fröhlich, M. M., V. Balázs, andG. L. Szepesy: Proteids of the Biological Fluids. Proceedings of the 9th Colloquium. Brugge, 1961, p. 276. Amsterdam: Elsevier Publ. Co. 1962.Google Scholar ...

https://link.springer.com/article/10.1007/BF00623681

... cryoglobulins explanation free. What is cryoglobulins? Meaning of cryoglobulins medical term. What does cryoglobulins mean? ... Looking for online definition of cryoglobulins in the Medical Dictionary? ... cryoglobulins. Also found in: Dictionary, Encyclopedia.. Related to cryoglobulins: cryoglobulinemia. cry·o·glob·u·lins. (krīō- ... Q The beginning of our procedure for testing a blood sample for cryoglobulins calls for heating the drawtube at 37[degrees]C ...

http://medical-dictionary.thefreedictionary.com/Cryoglobulins

... ,ARUP Laboratories is a national reference laboratory and ... Cryoglobulin, Qualitative. 2. Liquichek Qualitative Urine Toxicology Control. 3. bcr/abl, t(9;22) Translocation Qualitativeby ...

http://www.bio-medicine.org/medicine-products/Cryoglobulin--Qualitative-with-Reflex-to-Quantitative-IgA--IgG---26-IgM-22223-1/

Cryoglobulin. Does this test have other names?. Cryocrit, cryoprotein. What is this test?. This test is done to find out if you ... High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with a number of ... If your cryoglobulin test is positive, your healthcare provider will do more tests to find out the cause. ... A normal test is negative for cryoglobulins. This means the antibodies in your blood stay dissolved even when the blood is ...

http://www.ahealthyme.com/Library/DiseasesConditions/Adult/Arthritis/167,cryoglobulin

High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with a number of ... If your cryoglobulin test is positive, your healthcare provider will do more tests to find out the cause. ... A normal test is negative for cryoglobulins. This means the antibodies in your blood stay dissolved even when the blood is ... These abnormal blood proteins (cryoglobulins) are dissolved in your blood at the normal body temperature. But when you are in a ...

http://www.ahealthyme.com/Library/DiseasesConditions/Adult/Otolaryngology/167,cryoglobulin

Cryoglobulins come in three main types, but in 90% of cases, the cause is hepatitis C . The disease in which cryoglobulins are ... This test is most often done when a person has symptoms of a condition associated with cryoglobulins. Cryoglobulins are ... In the laboratory, cryoglobulins come out of solution in blood when the blood sample is cooled below 98.6 degrees Fahrenheit ( ... Cryoglobulins are abnormal antibody proteins. This article describes the blood test used to check for them. ...

https://www.stlukes-stl.com/health-content/health-ency-multimedia/1/003555.htm

High levels of cryoglobulins may be a sign that your body is making abnormal proteins. This condition is seen with some ... These abnormal blood proteins (cryoglobulins) are dissolved in your blood at the normal body temperature. But when you are in a ... If you test positive for cryoglobulins, it means these proteins became visibly thickened when your blood sample was chilled. ... This test is done to find out if you have abnormal proteins called cryoglobulins in your blood. ...

http://healthlibrary.brighamandwomens.org/InteractiveTools/Calculators/167,cryoglobulin

Munshower on cryoglobulin serum: It is very important to know why these were drawn in what sounds to be an otherwise healthy 19 ... Cryoglobulin (Definition) Immune proteins in the blood that can be seen in certain inflammatory and autoimmune conditions. ...

https://www.healthtap.com/topics/cryoglobulin-serum

Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ... Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ... Reduced opsonisation of protein A containing Staphylococcus aureus in sera with cryoglobulins from patients with active ...

https://ard.bmj.com/content/44/4/252.citation-tools

... Domenii publicaţii > ... Cuvinte cheie: Blood Protein; Cryoglobulin; Laser Deposition; Matrix Assisted Pulsed Laser Evaporation; Medical Physics ...

https://ad-astra.ro/2007/01/22/laser-deposition-of-cryoglobulin-blood-protein-thin-films-by-matrix-assisted-pulsed-laser-evaporation/

Find out information about Cryoglobulins. An abnormal protein, usually an immunoglobulin, which precipitates from plasma ... cryoglobulin. (redirected from Cryoglobulins). Also found in: Dictionary, Medical.. Related to Cryoglobulins: cryoglobulinemia ... Cryoglobulins , Article about Cryoglobulins by The Free Dictionary https://encyclopedia2.thefreedictionary.com/Cryoglobulins ... The cryoglobulin count in her blood steadily decreased, and by April of this year it was undetectable.. Cancer? She thought so ...

https://encyclopedia2.thefreedictionary.com/Cryoglobulins

Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection.. Research Project ... cryoglobulin / cold activation (CA) / C型肝炎 / 補体寒冷活性化 / クリオグロブリン / リウマトイド因子 / コールドアクチベーション / HCV / 可溶性IL-2レセプター / 非ホジキンリンパ腫 / 質量 ... The complement may be activated by an immune complex formed at a low temperature and this may be related to cryoglobulin. The ... The association of complement activation at a low temperature with hepatitis C virus infection

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672653/

... cryoglobulin explanation free. What is cryoglobulin? Meaning of cryoglobulin medical term. What does cryoglobulin mean? ... Looking for online definition of cryoglobulin in the Medical Dictionary? ... Related to cryoglobulin: cryofibrinogen, Cryoglobulin Test, cryoglobulinemia. cryoglobulin. [kri″o-glob´u-lin] a serum globulin ... Cryoglobulin , definition of cryoglobulin by Medical dictionary https://medical-dictionary.thefreedictionary.com/cryoglobulin ...

https://medical-dictionary.thefreedictionary.com/cryoglobulin

Cryoglobulin Alternative name:. Description:. Cryoglobulins are immunoglobulins which reversibly precipitate in the cold. Type ... Cryoglobulin quantitated and may be analysed further by elctrophoresis.. Restrictions:. For cryoglobulin screen, routine SST ... cryoglobulins are associated with B-cell lymphoma and myeloma whilst mixed cryoglobulins (type II and III) are associated with ... For cryoglobulin assay, sample must be collected and transported at 37°C. Sample is centrifuged and serum collected. On arrival ...

https://www.southtees.nhs.uk/services/pathology/tests/cryoglobulin/

AN ATYPICAL CASE OF AKI: WHEN CRYOGLOBULINS GO COLD. Hani Rashad Rashid, D.O.*1;Phuong Thy Nguyen, D.O.2;Roberto Collazo- ... Rashid, HR; Nguyen, PT; Collazo-Maldonado, R; Saleh, A . AN ATYPICAL CASE OF AKI: WHEN CRYOGLOBULINS GO COLD. Abstract ... caused by cryoglobulin-containing immune complex deposition and complement activation. Patients with type II (mixed) ... www.shmabstracts.com/abstract/an-atypical-case-of-aki-when-cryoglobulins-go-cold/. Accessed January 25, 2020. ...

https://www.shmabstracts.com/abstract/an-atypical-case-of-aki-when-cryoglobulins-go-cold/

This test is done to find out if you have abnormal proteins in your blood. They can be a sign of rheumatoid arthritis, lupus, or Raynaud syndrome, among other illnesses.

https://library.southcoast.org/Conditions/Bariatric/167,cryoglobulin

Normally, no cryoglobulins should be found in the body. Cryoglobulins more than often do not interact with red blood cells, ... Cryoglobulins are abnormal antibodies that only dissolve/disappear at temperature higher than 37 °C (99 °F) and form solid or ... Therefore, cryoglobulins dont produce hemolysis effect, however its serious complications such as systemic inflammatory or ... At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of ...

https://en.wikipedia.org/wiki/Cold_sensitive_antibodies

https://en.wikipedia.org/wiki/Cryoglobulinemia

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http://labtests.silvercross.org/cryoglobulin-qualitative-reflex