Cryogels: Macroporous hydrogels that are produced at subzero temperatures. Cryogels have pores that are produced by growing ice crystals and have been developed with a tissue-like elasticity that is suitable for cell immunization experiments.Chitosan: Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Schools, Health Occupations: Schools which offer training in the area of health.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Regeneration: The physiological renewal, repair, or replacement of tissue.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Biomedical Engineering: Application of principles and practices of engineering science to biomedical research and health care.Electronics, Medical: The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)TurkeyFaculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Transistors, Electronic: Electrical devices that are composed of semiconductor material, with at least three connections to an external electronic circuit. They are used to amplify electrical signals, detect signals, or as switches.BooksNanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Electrodes, Implanted: Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.Electrochemical Techniques: The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Illusions: The misinterpretation of a real external, sensory experience.Beetles: INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.Larva: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.Solanaceae: A plant family of the order Solanales, subclass Asteridae. Among the most important are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Solanum tuberosum: A plant species of the genus SOLANUM, family SOLANACEAE. The starchy roots are used as food. SOLANINE is found in green parts.ColoradoMesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Breast Neoplasms: Tumors or cancer of the human BREAST.Tumor Microenvironment: The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.Hydrogels: Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Hydrogel: A network of cross-linked hydrophilic macromolecules used in biomedical applications.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Heat-Shock Response: A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Heat-Shock Proteins: Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Cottonseed Oil: Oil obtained from the seeds of Gossypium herbaceum L., the cotton plant. It is used in dietary products such as oleomargarine and many cooking oils. Cottonseed oil is commonly used in soaps and cosmetics.Resins, Plant: Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Body Composition: The relative amounts of various components in the body, such as percentage of body fat.

Detachment of affinity-captured bioparticles by elastic deformation of a macroporous hydrogel. (1/9)

Adsorption of bioparticles to affinity surfaces involves polyvalent interactions, complicating greatly the recovery of the adsorbed material. A unique system for the efficient binding and release of different cells and particles is described. Affinity-bound bioparticles and synthetic particles are detached from the macroporous hydrogel matrix, a so-called cryogel, when the cryogel undergoes elastic deformation. The particle detachment upon elastic deformation is believed to be due to breaking of many of the multipoint attachments between the particles and the affinity matrix and the change in the distance between affinity ligands when the matrix is deformed. However, no release of affinity-bound protein occurred upon elastic deformation. The phenomenon of particle detachment upon elastic deformation is believed to be of a generic nature, because it was demonstrated for a variety of bioparticles of different sizes and for synthetic particles, for different ligand-receptor pairs (IgG-protein A, sugar-ConA, metal ion-chelating ligand), and when the deformation was caused by either external forces (mechanical deformation) or internal forces (the shrinkage of thermosensitive, macroporous hydrogel upon an increase in temperature). The elasticity of cryogel monoliths ensures high recovery of captured cells under mild conditions, with highly retained viability. This property, along with their continuous porous structure makes cryogel monoliths very attractive for applications in affinity cell separation.  (+info)

Supermacroprous chitosan-agarose-gelatin cryogels: in vitro characterization and in vivo assessment for cartilage tissue engineering. (2/9)

 (+info)

Apparent heterogeneity in the pIII-peptide fusion protein in single-phage clones isolated from peptide libraries. (3/9)

 (+info)

Injectable preformed scaffolds with shape-memory properties. (4/9)

 (+info)

Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. (5/9)

Design of macroporous synthetic grafts that can promote infiltration of cells, their differentiation, and synthesis of bone-specific extracellular matrix is a key determinant for in vivo bone tissue regeneration and repair. In this study, we investigated the effect of the microarchitecture of the scaffold on osteogenic differentiation of human mesenchymal stem cells (hMSCs). Poly(ethylene glycol) diacrylate-co-N-acryloyl 6-aminocaproic acid cryogels were fabricated to have either a pore network consisting of cellular, randomly oriented pores (termed 'spongy') or a pore network consisting of lamellar columns (termed 'columnar'), with both cryogel types showing a similar porosity. Both spongy and columnar cryogels supported comparable levels of cell viability and proliferation of hMSCs in vitro. However, spongy cryogels promoted osteogenic differentiation to a greater extent than their columnar counterparts, as evidenced by increased alkaline phosphatase activity and osteoblastic gene expression over 21 days post culture. Leveraging upon our previous work, we further evaluated the ability of these synthetic scaffolds in conjunction with mineralisation to promote ectopic bone formation upon subcutaneous implantation in nude rats. Mineralised spongy and columnar cryogels, both in the presence and absence of exogenous hMSCs, promoted ectopic bone formation in vivo. No such bone formation was observed in acellular cryogels devoid of mineralisation, with extensive host cell infiltration and vascularisation in columnar cryogels, and negligible infiltration into spongy cryogels. Our results thus present a novel method to tune the microarchitecture of porous polymeric scaffolds, in addition to suggesting their efficacy as synthetic bone grafts.  (+info)

Designing polysaccharide-based antibacterial biomaterials for wound healing applications. (6/9)

 (+info)

Effect of alpha-ketoglutarate on growth and metabolism of cells cultured on three-dimensional cryogel matrix. (7/9)

 (+info)

Three-dimensional supermacroporous carrageenan-gelatin cryogel matrix for tissue engineering applications. (8/9)

 (+info)

The influence of temperature, pH and ionic strength on the adsorption of Immunoglobulin Y (IgY) in IDA-Cu(2+) cryogel system was studied by batch equilibrium measurements.
Poly(HEMA) cryogel disks were synthesized by free radical polymerization of 2-hydroxy-ethylmethacrylate (HEMA), and then Cibacron Blue F3GA (CB), Reactive Green 19 (RG) and Congo Red (CR) were immobilized as dye ligands. Disks were...
Feng, Y., Xue, Y., Guo, J., Cheng, L., Jiao, L., Zhang, Y. and Yue, J. (2009), Synthesis and characterization of poly(carbonate urethane) networks with shape-memory properties. J. Appl. Polym. Sci., 112: 473-478. doi: 10.1002/app.29426 ...
Pre-Shaped Injectable Jelly for Drug Delivery and Tissue Support by STANLEY DARMA on Nov 15, 2012 • 10:52 am 0 inShare Left: A fully collapsed square-shaped cryogel rapidly regains its original memorized shape, size, and volume upon hydration. Right: Photos show the placement of a cryogel inside a 1-mL syringe, and the recovery of a square gel after injection through a normal 16-gauge needle. (Images courtesy of Sidi Bencherif.) Bioengineers at Harvard School of Engineering and Applied Sciences have come up with…. Read More → ...
Materials and Methods. Microorganism, media and cultivation. The R. wratislawiensis BN38, employed in this study was isolated from soil polluted with hydrocarbons by a standard enrichment technique (Tuleva et al., 2008). Minimal salt medium (MSM) with the following composition (g/l): K2HPO4.3H2O, 4.8; KH2PO4, 1.5; (NH4)2SO4, 1.0; MgSO4.7H2O, 0.2; supplemented with trace element solution (mg/l): CaCl2.2H2O, 2.0; MnCl2.4H2O, 0.4; NiCl2.6H2O, 0.4; ZnSO4.7H2O, 0.4; FeCl3.6H2O, 0.2; Na2MoO4.2H2O, 0.2 and phenol and n-hexadecane at 500 mg/l, unless otherwise mentioned, was used. The pH of the medium was adjusted to 7.0. The MSM was solidified as MSM phenol agar by addition of 1.8 % agar when necessary. Cultures grown on MSM agar supplemented with 500 mg/l phenol were used to inoculate 500 ml Erlenmeyer flasks, containing 100 ml liquid MSM. At each cycle MSM was supplemented to 100 ml with fresh sterile medium without cell transfer and only phenol was added. Cultures were incubated during the long-term ...
Pulse wave imaging (PWI) is an ultrasound-based method to visualize the propagation of pulse wave and to quantitatively estimate regional pulse wave velocity (PWV) of the arteries within the imaging field of view (FOV). To guarantee the reliability of PWV measurement, high frame rate imaging is required, which can be achieved by reducing the line density of ultrasound imaging or transmitting plane wave at the expense of spatial resolution and/or signal-to-noise ratio (SNR). In this study, a composite, full-view imaging method using motion matching was proposed with both high temporal and spatial resolution ...
Eichhorn, T.; Ivanov, A.E.; Dainiak, M. B.; Leistner, A.; Linsberger, I.; Jungvid, H.; Mikhalovsky, S. V.; Weber, V. (2013). Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites from blood. Journal of Chemistry, 2013: 348412 ...
The present invention provides a composition that softens at a predetermined temperature, preferably between about 20 C. and 90 C., and more preferably between about 20 C. and about 62 C., comprising at least one block copolymer having at least two thermal transition temperatures. The composition is characterized by at least two thermal transition temperatures, one of which is a predetermined lower transition temperature, preferably between about 20 C. to 90 C., and more preferably between about 20 C. to about 62 C., and one of which is an upper transition temperature. The present invention also provides a method of making the composition, a method of making biomedical materials and articles, and toys and toy components, with shape-memory properties from the composition, and biomedical materials and articles, and toys and toy components, with shape-memory properties made from the composition.
Available literature values for T1 are approximately. 400 ms, 600 ms, 800 ms and 1100 ms at 1 T, 1.5 T, 1.9 T and 3 T, respectively [16] and [21]. Our value of T1 of 1656 ms measured at 7 T confirms the overall trend of increasing T1 with field strength. For T2, there appears to be little change with field strength. The observed fall in T1 and T2 with the number of freeze-thaw cycles also confirms previous reports [16] and [17], although only the T1 values for two and four cycles reached statistical significance. Available see more literature values for myocardial T1 are 1300 ms in rat at 4.7 T [22] and 952 ms in mouse at 9.4 T [23], rather lower than our PVA Cryogel phantoms. However, our primary design goal was to generate realistic myocardial motion rather than exact matching of relaxation times. Use of a pure sinusoidal flow from the pump resulted in eventual collapse. of the phantom at "end systole," so that an offset sinusoid was used. In practice, the amplitude and degree of offset were ...
Our group brings together researchers investigating various aspects of cell organisation and dynamics. A major focus is to understand the mechanisms underlying the biosynthesis, targeting and trafficking of proteins within the cell. We also investigate membrane and cytoskeletal dynamics, intracellular ion homeostasis and the cellular processes responsible for plant growth and development. A major goal is to decipher how defects in these processes leads to disease.
Mouse eyes were immediately enucleated from euthanized animals, lenses were dissected in PBS and then immersed into 4% paraformaldehyde (PFA) in PBS at 37°C for 30 minutes. The fixed lenses were washed three times with PBS then sectioned into 150-μm slices with a vibratome (Leica VT1000 S; Leica, Wetlar, Germany). The slices were postfixed for 2 minutes in 4% PFA in PBS then washed three times with PBS before immunohistochemical analysis. A rabbit antibody against the intracellular loop of Cx46,26 a rabbit antibody against the C-terminal region of Cx50,27 a rabbit anti-βDystroglycan (anti-βDys) antibody (MANDAG2[7D11]; Developmental Studies Hybridoma Bank, Iowa City, IA, USA), and a rabbit anti-ZO-1 antibody (40-2200; Thermo-Fisher, Waltham, MA, USA) were used. Antigen retrieval was performed on sections destined for antibody labeling with the exception of anti-Cx50 labeling. The sections were placed in citrate buffer (10 mM sodium citrate, 0.05% vol/vol Tween 20) at 80°C for 30 minutes ...
Basin simulators have been used previously for deriving subsalt velocity models with the use of a correlation to relate effective stress to velocity. We build on this, and the work of others, to use physical models to relate porosity to velocity for migrating seismic data. This process yields a physically realizable isotropic velocity model that is consistent with the geologic model and matches the tomographic velocity model above salt and in regions where the tomographic velocity estimate is accurate. We then use a geomechanical simulator to model the stress distribution in and around allochthonous salt where material properties between salt and sediment change. Our stress model is the basis for an anisotropic velocity model using Murnaghans theory for finite elastic deformation. This formulation, with bounds placed on the elastic coefficients, leads to significant imaging improvements adjacent to salt. ...
Qianxiao Li: Free-energy-like concepts for nonequilibrium systems; Cheng Tai: Video Super-Resolution via Adaptive Wavelet Frames and Elastic Deformations ...
Cells are the structural and functional units of all living organisms. Some organisms, such as bacteria, are unicellular, consisting of a single cell. Other organisms, such as humans, are multicellular, or have many cells - an estimated 100,000,000,000,000 cells! Each cell is an amazing world unto itself: it can take in nutrients, convert these nutrients into energy, carry out specialized functions, and reproduce as necessary. Even more amazing is that each cell stores its own set of instructions for carrying out each of these activities. *Cell Organization* Before we can discuss the various components of a cell, it is important to ...
article{c02feb63-0c75-498d-9b63-6043d6df0ab2, abstract = {Background: Phage Display technology is a well established technique for high throughput screening of affinity ligands. Here we describe a new compact chromato-panning procedure for selection of suitable binders from a phage peptide display library. Results: Both phages and E. coli cells pass non-hindered through the interconnected pores of macroporous gel, so called cryogel. After coupling a ligand to a monolithic cryogel column, the phage library was applied on the column and non-bound phages were washed out. The selection of strong phage-binders was achieved already after the first panning cycle due to the efficient separation of phage-binders from phage-non-binders in chromatographic mode rather than in batch mode as in traditional biopanning procedures. E. coli cells were applied on the column for infection with the specifically bound phages. Conclusion: Chromato-panning allows combining several steps of the panning procedure ...
Shape-memory materials are featured by their ability to recover their original shape from a significant and seemingly plastic deformation when a particular stimulus is applied, which is known as the shape-memory effect.17-20,39-41 Shape-memory materials have been utilized in many fields, from aerospace engineering (e.g., in deployable structures and morphing wings) to medical devices (e.g., in stents and filters). Figure 1.3c and d show an example of a reversible bidirectional shape-memory free-standing copolymer network with two types of crystallizable domains that is capable of a fully reversible bidirectional shape-memory effect.41 This copolymer network is made of a multiphase copolyester urethane and consists of one set of crystallizable domain that determines the shape-shifting geometry, while the other domain of the network provides the thermally controlled actuation capability. This reversible bidirectional shape-memory technology can be inspirational to the design of many smart devices ...
A deformation sensor, which has excellent workability and a high degree of freedom in shape design and which can detect deformation and load in a wide area of components and portions, has a main body of sensor, electrodes which are connected to the main body of sensor and can output electric resistances, and a restraining component which restrains elastic deformation of at least a part of the main body of sensor. The main body of sensor has an elastomer, and spherical conductive fillers which are blended into the elastomer at a high filling rate in an approximately single-particle state, and is elastically deformable. In the main body of sensor, as an elastic deformation increases, the electric resistance increases.
An initial stress within a solid can arise to support external loads or from processes such as thermal expansion in inert matter or growth and remodelling in living materials. For this reason, it is useful to develop a mechanical framework of initially stressed solids irrespective of how this stress formed. An ideal way to do this is to write the free energy density psi in terms of initial stress tau and the elastic deformation gradient F, so we write psi = psi(F, tau). In this paper, we present a new constitutive condition for initially stressed materials, which we call the initial stress symmetry (ISS). We focus on two consequences of this condition. First, we examine how ISS restricts the possible choices of free energy densities psi = psi (F, tau) and present two examples of psi that satisfy the ISS. Second, we show that the initial stress can be derived from the Cauchy stress and the elastic deformation gradient. To illustrate, we take an example from biomechanics and calculate the optimal ...
Dec. 23, 2012 ? Scientists at The University of Manchester have identified how cells know which way up they need to be. The discovery could help in the fight against cancer because in the early stages of the disease the cells become disorganised.. Professor Charles Streuli and Dr Nasreen Akhtar of the Wellcome Trust Centre for Cell-Matrix Research have conducted new research that leads to a better understanding of cell polarity. Properly organised tissues are vital to maintaining functional organs and a healthy body. Part of being organised includes cells being in the correct position within the tissue and the right way up, because the top and bottom of cells have different functions.. The extracellular matrix (ECM) is a layer of protein rich material that surrounds tissues and helps to design and shape all of our organs. Previous studies have demonstrated that the ECM sticks to the cells and guides them into the right position. What hadnt been identified is how the ECM communicates that ...
This highly regarded hardcover engineering manual is mainly concerned with three important aspects of elasticity theory: finite elastic deformations, complex va
In some cases when the generated stress is immense, there is a rapid energy transfer through the dense and ordered packing of molecular single crystals and they are self-actuated by elastic deformation and/or by a ballistic event. This self-actuation phenomenon of crystals is termed thermosalient effect (Hüpf-Effekt) and is extremely rare propensity of certain crystalline solids capable of bending, twisting, curling, rolling or locomotion [2]. These systems are a prototype materials for novel, environmentally clean and efficient thermal-to-mechanical energy transformation. The capability of rapid energy transfer through the dense and ordered packing of single crystals evolves as a new platform for efficient dynamic elements, including artificial tissues and microfluidic elements. The fast energy transfer secured by efficient coupling between the thermal energy and mechanical energy stand as their main assets towards the design of fast actuators. The thermosalient effect is often accompanied ...
Zhu, X.L., Zhang, Y., Chandra, D., Cheng, S.C., Kikkawa, J.M. and Yang, S. Two-dimensional photonic crystals with anisotropic unit cells imprinted from poly(dimethylsiloxane) membranes under elastic deformation. Appl. Phys. Lett. 93, doi:10.1063/1.3006061 (2008). * (Selected to November 10, 2008 issue of Virtual J. Nanoscale Sci. & Tech., Am. Inst. Phys. & Am. Phys. Soc ...
While officials in the executive branch, members of Congress and senior congressional staffers spin in and out of the private and public sectors, so too does privilege, power, access and, of course, money.
A novel minicolumn chromatographic method to monitor the production of inclusion bodies during fermentation and an enzyme-linked immunosorbent assay (ELISA) system allowing direct analysis of the particles with surface-displayed antigens are described. A 33-kDa protein containing 306 amino acids with three sulfur bridges produced as inclusion bodies was labeled with polyclonal antibodies against 15 amino acid (anti-A15) and 17 amino acid (anti-B17) residues at the N- and C-terminal ends of the protein, respectively. Labeled particles were bound to macroporous monolithic protein A-cryogel adsorbents inserted into the open-ended wells of a 96-well plate (referred to as protein A-cryogel minicolumn plate). The concept behind this application is that the binding degree of inclusion bodies from lysed fermentation broth to the cryogel minicolumns increases with an increase in their concentration during fermentation. The technique allowed us to monitor the increase in the production levels of the ...
This Cell Organization Worksheet is suitable for 9th Grade. In this cell organization worksheet, 9th graders conduct an experiment to create a three-dimensional model of a cell. Then they determine what items used from the list provided on cell parts and their various functions.
Effects of silica-gentamicin nanohybrids on osteogenic differentiation of human osteoblast-like SaOS-2 cells Wei He,1 Dina A Mosselhy,2,3 Yudong Zheng,1 Qingling Feng,4 Xiaoning Li,4 Xing Yang,4 Lina Yue,1 Simo-Pekka Hannula2 1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, Peopleâ s Republic of China; 2Department of Chemistry and Materials Science, School of Chemical Engineering, Aalto University, Espoo, Finland; 3Microbiological Unit, Fish Diseases Department, Animal Health Research Institute, Giza, Egypt; 4State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, Peopleâ s Republic of China Introduction: In recent years, there has been an increasing interest in silica (SiO2) nanoparticles (NPs) as drug delivery systems. This interest is mainly attributed to the ease of their surface functionalization for drug loading. In orthopedic applications, gentamicin-loaded SiO2
Cell polarity is the property of cells to be spacially oriented in a tissue or organ. Loss of cell polarity is a hallmark of cancer and is associated with more aggressive tumours. In this grant, we propose experiments to understand a new family of proteins that act on cell polarity and proliferation to prevent cancer. We will study how the protein hScrib regulates the behaviour of breast cancer cells and assess whether alterations in hScrib are important for cancer development ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Although most materials slightly expand when heated, there is a new class of rubber-like material that not only self-stretches upon cooling; it reverts back to its original shape when heated, all without physical manipulation.
Flexible displays, electronics and even batteries are currently being tested and will be part of our daily lives in a matter of years. The technology also holds tremendous promise for medical research and could contribute to treatment of Alzheimer's disease and a host of other conditions. But first, you need to find appropriate materials.
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
i would like to optimize over elastic deformation of a body (finding the best deformation in some sens), under the constraint that we never reach the elastic limit. In the optimization procedure, i am wondering if i should go over all points of the body and check if the constraint is verified, or if it is sufficient to check on the surface. This would reduce the computational complexity of the optimization ...
Abstract: The open arc welding robots have been used widely nowadays; however, the elastic deformations of every inner link inevitably affect the welding quality. In this paper, it proposes an effective method of service reliability assessment for the rigidity-flexibility coupling open arc welding robot. Firstly, a parametric virtual model of the robot is built in ADAMS/View-AutoFlex module. Secondly, the stochastic errors generated in the working process are simulated by a program created from pseudo-random numbers which have been written by multiplicative congruence method. Lastly, Monte Carlo sampling calculation is implemented for the virtual model, and large sample data of the dynamic characteristics in welding process are obtained and used to calculate the service reliability of the welding robot. This method includes simplicity (no need to solve complex mathematic model) and high accuracy which make it highly promising for application in mechanism design ...
A heart pacemaker system has an electrode line with a proximal end which is introduced into a connector of the pacemaker housing, and a distal end having an electrode head attachable to the heart of a user. One or more of the distal or proximal ends of the electrode line, the connector, or a region of the electrode line are provided with a component consisting of shape-memory metal. These components have a first shape at temperatures different from body temperature, and assume a second shape when at body temperature. The shape-memory metal component, if disposed at the proximal end of the electrode line or at the connector, is arrnaged to provide a firm mechanical and electrical connection of the electrode line with the pacemaker housing upon the change of shape of the component. The shape-memory metal component, if disposed at the distal end, is arranged to assist in providing, either directly or indirectly, a reliable, mechanical and electrical connection of the electrode line to the heart upon the
Intermediate two-dimensional scanning with a three-dimensional scanner to speed registration | Proximity sensor device | Radar system and method | Device and method for judging likelihood of collision between vehicle and target, vehicle collision avoidance... | Radar device and method of processing signal |
Lipid bilayers form the boundaries of the cell and its organelles. Many physiological processes, such as cell movement and division, involve bending and folding of the bilayer at high curvatures. Currently, bending of the bilayer is treated as an elastic deformation, such that its stress-strain response is i
The analysis of rubber-like materials undergoing large elastic deformations is a key topic in field of active polymers, like ionic polymers, hydrogels and nematic elastomers, as well as in biomechanics, for soft tissues. For biomechanics, the hot issue relays in the development of mathematical-physical models that are able to describe the behaviour of physiological processes involving highly deformable tissues, like the skin or the muscles, or hard tissue as cartilage and bones. Such bio-mechanical models and their validation through experiments in vivo or in vitro can be helpful for better understanding physiological processes, for the planning of surgical interventions, or even for designing advanced prosthetic devices. In our case, we focused on the development of a model that describes the contraction of cardiac tissue based on the notion of active distortions. Then, our model has been implemented in a computational code in order to asses its performance through a series of numerical ...
At the California Institute of Technology (F. Cirak, M. Ortiz) and at Rutgers University (A. M. Cuitiño ) further sophisticated computer calculations on the elastic deformations of an ultra-thin foil were undertaken. The resulting pictures were quite realistic. The fact that the foil folds very irregularly (first occurring when the plate holding the foil experiences a temperature difference of only one degree) is caused by the way in which it was manufactured. The thin foil is stretched over an approximately four-millimeter hole in a platinum holder and attaches itself to the platinum through adhesion alone. Although the foil over the hole is self-supporting, it is not stretched in a uniform manner. This tension works, at first, to stabilize the smooth form of the foil, so that with small temperature increases no folds appear. The computer simulations showed that if the samples were perfectly symmetrical, they would begin to bend with the smallest temperature increases. If the temperature ...
A cart for weighing small animals with the cart having a torsional undercarriage mechanism that directs the weight of an animal in a weighing pen through a single tension support member wherein the elastic deformation of the single tension support member is measured with an electrical resistance strain gauge mounted on the tension support member and a conventional digital strain gauge read-out device.
NEW YORK (Reuters Health) - Women on chemotherapy for breast cancer may have tiny memory and thinking impairments compared with cancer-free women more than 20...
4. I asked the wrong question. How do the homologous chromosomes pair up (mate/join)? How do they recognize that chromosome with whom to pair? If there are different genes on different chromosomes, I assume that this pairing would have to have 2 chromosomes with the same set of genes. Is this the 1 and the 2 of the 2n (one from the mother side, one from the father side)? Thus each pair of homologous chromosomes have a total of 4 sister chromatids, 2 on each of the homologous chromosomes. How the chromosomes pair correctly is my biggest stumbling point ...
Introduction. Plastics Plastics are often frowned upon. This is because people often think of them as cheap and not aesthetically pleasing. However they come in many different forms and often look very nice. Obviously there are types that do give the product a bad name. Mainly the cheap toys that are produced in the far east. This is not right and plastics should be seen as a real alternative and be able offer a huge amount of uses for this product. Polymers Polymers such as rubber, plastics and adhesives are organic structures. They can be natural, like amber and shellac, modified natural materials, like cellulose and casein, or synthetic, like nylon and polypropylene. ...read more. Middle. When subjected to pressure, thermoplastics can deform in two ways. Elastic deformation occurs in which the initially curled long chains stretch out and this deformation is recovered when the pressure is removed. At higher temperatures or pressures, viscous or plastic deformation occurs in which the secondary ...
Abstract. Mass-spring systems are of special interest for soft tissue modeling in surgical simulation due to their ease of implementation and real-time behavior. However, the parameter identification (masses, spring constants, mesh topology) still remains a challenge. In previous work, we proposed an approach based on the training of mass-spring systems according to known reference models. Our initial focus was the determination of mesh topology in 2D. In this paper, we extend the method to 3D. Furthermore, we introduce a new approach to simultaneously identify mesh topology and spring sti ness values. Linear elastic FEM deformation computations are used as reference. Additionally, our results show that uniform distributions of spring sti ness constants fails to simulate linear elastic deformations. ...
The DEPARTMENT OF CELLULAR AND MOLECULAR BIOLOGY focuses on understanding the cell, the basic unit of Life. This Department gathers laboratories whose research interests span fundamental processes at the core of cell organization and function: the arrangement, replication and stability of genomes, epigenetics in gene expression, intracellular traffic, cell division, differentiation and evolution, and cellular recycling through programmed death. These studies converge with bottom-up endeavours, such as exploring the interactions between cells and biomaterials or the reconstruction and engineering of macromolecular assemblies. The model systems used to study these processes range from unicellular microorganisms, both bacteria and fungi, to mammalian cells and animal models. Our approaches are interdisciplinary, a watermark of CIB, and bridge methodologies ranging from advanced optical and electron microscopies to functional genomics, with strong inputs from molecular biology, biophysics and ...
The invention concerns a device comprising a support (11) in the thickness of which is produced a supply chamber (12) with an inlet duct (13) for nutrient liquid and a discharge duct (14) for said liquid. A capsule (22) capable of receiving organic cells is provided on the support (11). The supply chamber (12) and the support (11) are separated by a porous membrane (16) comprising an array of electrodes (17) arranged so as to be in contact with different zones of the group of cells, thereby enabling their electrophysiological activity to be analyzed. The device enables to increase the life span of cells and to carry out analyses simply and without affecting the cell organization.
This thesis describes the production of two types of hierarchical macroporous polymers using the emulsion templating technique. The first are those with a hierarchy of macroporous, defined as the efficient packing of pores with multi-modal pore size distributions. The second are macroporous polymers containing a hierarchical particulate network, defined by an interconnected particle network within the polymer matrix. In the first section of the thesis, macroporous hierarchy was achieved using 3 different methods. In the first method, the properties of surfactant stabilised high internal phase emulsion (HIPE) were optimised by varying selected emulsification parameters such as the surfactant concentration and stirring rate. The Finite Element Method (FEM) was subsequently used to qualitatively compare and validate the effect of pore hierarchy on the Youngs modulus of macroporous polymers. It was believed that the hierarchical arrangement of macropores facilitated the load transfer during ...
The gland pattern of Barretts glands is that of glands of the pyloric mucosa: the proliferative zone is housed within the isthmus/neck equivalent of the gland, and cell migration is bidirectional, upwards into the foveolus equivalent, and downwards into the tubules of the gland base. The stem cell zone, as indicated by the presence of LGR5 mRNA+ cells, is located in the lower part of this area, almost at the level of the D/PAS+, TFF2+, MUC6+ cells (figure 4), while LGR5 mRNA+ cells in the antral glands are seen mainly in the isthmus/neck. MUC5AC and TFF1 are found in the upper part of the gland, while TFF2 and MUC6 concentrated in the D/PAS cells at the gland base, as seen in antral gastric glands. MUC2, and to a lesser extent TFF3, is seen predominantly in goblet cells in the upper part of the gland. The organisation of Barretts glands, their proliferative architecture, stem cell localisation and patterns of gene expression, directly reflects the pyloric gastric gland. We conclude that ...
The symbolic modeling of flexible multibody systems is a challenging task. This is especially the case for complex-shaped elastic bodies, which are described by a numerical model, e.g., an FEM model. The kinematic and dynamic properties of the flexible body are in this case numerical and the elastic deformations are described with a certain number of local shape functions, which results in a large amount of data that have to be handled. Both attributes do not suggest the usage of symbolic tools to model a flexible multibody system. Nevertheless, there are several symbolic multibody codes that can treat flexible multibody systems in a very efficient way. In this paper, we present some of the modifications of the symbolic research code Neweul-M2 which are needed to support flexible bodies. On the basis of these modifications, the mentioned restrictions due to the numerical flexible bodies can be eliminated. Furthermore, it is possible to re-establish the symbolic character of the created equations ...
The ability to measure 3D orientation fields and to determine grain boundary character plays a key role in understanding many material science processes, including: crack formation and propagation, grain coarsening, and corrosion processes. X-ray diffraction imaging techniques offer the ability to retrieve such information in a non-destructive manner. Among them, Diffraction Contrast Tomography (DCT) is a monochromatic beam, near-field technique, that uses an extended beam and offers fast mapping of 3D sample volumes. It was previously shown that the six-dimensional extension of DCT can be applied to moderately deformed samples (≤ 5% total strain), made from materials that exhibit low levels of elastic deformation of the unit cell (≤ 1%). In this article, we improved over the previously proposed 6D-DCT reconstruction method, through the introduction of both a more advanced forward model and reconstruction algorithm. The results obtained with the proposed improvements are compared against the ...
We have studied the elastic deformation of freely suspended atomically thin sheets of muscovite mica, a widely used electrical insulator in its bulk form. Using an atomic force microscope, we carried
Increase your rabbits activity level and encourage bladder emptying by providing large exercise areas along with plenty of fresh water. Providing multiple sources of fresh water in several locations and flavoring the water with fruit and/or vegetable juices (with no added sugars) may also be helpful. Reduce calcium in diet to discourage formation of calcium stones in the bladder and urinary tract. Encourage oral fluid intake by wetting leafy vegetables, and offer a large selection of fresh, moistened greens such as cilantro, romaine lettuce, parsley, carrot tops, dandelion greens, spinach, collard greens, and good-quality grass hay. Feed timothy and grass hay instead of alfalfa hay and discontinue alfalfa pellets from your rabbits daily feeding unless your veterinarian instructs otherwise.. Monitor your rabbits urine output and contact your veterinarian if the symptoms should recur.. ...
This paper investigates the use of shape-memory polymer thin films in microelectromechanical systems (MEMS). shape-memory polymers possess the capacity to
The key to Orville and Wilbur Wrights historic 1903 flight was wing warping. Today, NASA engineers are developing a similar technique to increase the performance and efficiency of fixed-wing aircraft. The goal is to be able to bend and fold wings in-flight without using complex hydraulic systems or mechanical linkages. In the future, subsonic and supersonic aircraft equipped with the technology may weigh up to 80 percent less than aircraft that rely on traditional wing flaps. The Spanwise Adaptive Wing (SAW) project aims to validate . . .
Preface xv. 1. Failure Analysis 1. I. Introduction 1. II. Examples of Case Studies Involving Structural Failures 6. III. Summary 25. References 25. Problems 26. 2. Elements of Elastic Deformation 27. I. Introduction 27. II. Stress 27. III. Strain 32. IV. Elastic Constitutive Relationships 35. V. State of Stress Ahead of a Notch 44. VI. Summary 46. References 46. Appendix 2-1: Mohr Circle Equations for a Plane Problem 46. Appendix 2-2: Three-Dimensional Stress Analysis 49. Appendix 2-3: Stress Formulas Under Simple Loading Conditions 54. Problems 57. 3. Elements of Plastic Deformation 59. I. Introduction 59. II. Theoretical Shear Strength 59. III. Dislocations 61. IV. Yield Criteria for Multiaxial Stress 68. V. State of Stress in the Plastic Zone Ahead of a Notch in Plane-Strain Deformation 70. VI. Summary 74. For Further Reading 75. Appendix 3-1: The von Mises Yield Criterion 75. Problems 76. 4. Elements of Fracture Mechanics 80. I. Introduction 80. II. Griffiths Analysis of the Critical Stress ...
Adenosine triphosphate (ATP) is the universal chemical energy currency for cellular activities provided mainly by the membrane enzyme FoF1-ATP synthase in bacteria, chloroplasts and mitochondria. Synthesis of ATP is accompanied by subunit rotation within the enzyme. Over the past 15 years we have developed a variety of single-molecule FRET (smFRET) experiments to monitor catalytic action of individual bacterial enzymes in vitro. By specifically labeling rotating and static subunits within a single enzyme we were able to observe three-stepped rotation in the F1 motor, ten-stepped rotation in the Fo motor and transient elastic deformation of the connected rotor subunits. However, the spatial and temporal resolution of motor activities measured by smFRET were limited by the photophysics of the FRET fluorophores. Here we evaluate the novel FRET donor mNeonGreen as a fusion to FoF1-ATP synthase and compare it to the previously used fluorophore EGFP. Topics of this manuscript are the biochemical ...
Instructive materials able to drive cells, in particular the differentiation of stem cells toward osteoblastic lineages have been investigated as a promising strategy for bone tissue engineering. Inorganic ions, such as phosphorous, calcium, silicon and strontium, have been used in bone regeneration strategies as instructive ions for material based approaches. The use of effective inorganic ions are being investigated as a promising approach for bone regeneration applications mainly due to the fact that are highly available and cost-effective and thus, reducing the need of using expensive and less stable growth factors. The aim of present study is to investigate the effect of the release of silicon (Si) and calcium (Ca) ions from blend of starch and poly-caprolactone (SPCL) scaffolds on the osteogenic behavior of human adipose stem cells (hASC). The scaffolds were developed by a wet-spinning technique and two different solutions were used as coagulation bath, one containing Ca and Si ions and ...
This Ni-rich Ti/Ni foil falls under a class of materials called a shape-memory alloy(SMA) which means that the material always wants to return to the shape at which it was cold forged. Having a material be a SMA is ideal for origami engineering since it will want to spring back to its original shape after being folded. Another wonderful property of this material is that it is biocompatable with the body and will induce no negative immune response[6]. The reason why such materials were not used before, is because it was very challenging and expensive to make a TiNi foil (or another biocompatable SMA) so thin while retaining its properties. Now due to research from the early 2000s, it is possible to create such a material relatively inexpensively[1]. To tailor program the cylindrical shape memory Kuribayashi and You aged the material at 773k for 20-40h[1]. Next a folding pattern is devised and creases are applied to the foil by using a negative photo-chemical etching process[1]. Following the ...
This Ni-rich Ti/Ni foil falls under a class of materials called a shape-memory alloy(SMA) which means that the material always wants to return to the shape at which it was cold forged. Having a material be a SMA is ideal for origami engineering since it will want to spring back to its original shape after being folded. Another wonderful property of this material is that it is biocompatable with the body and will induce no negative immune response[6]. The reason why such materials were not used before, is because it was very challenging and expensive to make a TiNi foil (or another biocompatable SMA) so thin while retaining its properties. Now due to research from the early 2000s, it is possible to create such a material relatively inexpensively[1]. To tailor program the cylindrical shape memory Kuribayashi and You aged the material at 773k for 20-40h[1]. Next a folding pattern is devised and creases are applied to the foil by using a negative photo-chemical etching process[1]. Following the ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Kim, D. H., DAléo, A., Chen, X. K., Sandanayaka, A. D. S., Yao, D., Zhao, L., Komino, T., Zaborova, E., Canard, G., Tsuchiya, Y., Choi, E., Wu, J. W., Fages, F., Brédas, J. L., Ribierre, J. C. & Adachi, C., Feb 1 2018, In : Nature Photonics. 12, 2, p. 98-104 7 p.. Research output: Contribution to journal › Article ...
A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.
In this study, omniphobic fluorogel elastomers were prepared by photocuring perfluorinated acrylates and a perfluoropolyether crosslinker. By tuning either the chemical composition or the temperature that control the crystallinity of the resulting polymer chains, a broad range of optical and mechanical properties of the fluorogel can be achieved. After infusing with fluorinated lubricants, the fluorogels showed excellent resistance to wetting by various liquids and anti-biofouling behavior, while maintaining cytocompatiblity. ...
Protein-mediated membrane fusion is essential for maintaining eukaryotic cell organization and propagation of major human viruses. Many clinically relevant memb...
Smith hands his original to the German colonel, who is enraged to find it is blank. It turns out its Smith whos really a triple agent, and the NCOs are who they say they are, double agents. Smith has spent the last two years feeding false information to his German counterpart to set up the identity of a double agent. Really, hes been working for the Brits all along. Schaffer is allowed to retrieve his gun again. Smith announces that the entire operation, including planting the false general and infiltrating the base, was a scam to allow them to expose the German double agents in the U.K. and obtain the names of their collaborators ...
The present invention relates to shape deformable materials, which are capable of (1) being deformed, (2) storing an amount of shape deformation, and (3) recovering at least a portion of the shape deformation when exposed to electromagnetic radiation (EMR) energy. The shape deformable materials can advantageously be in the form of films, fibers, filaments, strands, nonwovens, and pre-molded elements. The shape deformable materials of the present invention may be used to form products, which are both disposable and reusable. More specifically, the shape deformable materials of the present invention may be used to produce products such as disposable diapers, training pants, incontinence products, and feminine care products.
There is growing clinical demand for image registration techniques that allow multimodal data fusion for accurate targeting of needle biopsy and ablative prostate cancer treatments. However, during procedures where transrectal ultrasound (TRUS) guidance is used, substantial gland deformation can occur due to TRUS probe pressure. In this paper, the ability of a statistical shape/motion model, trained using finite element simulations, to predict and compensate for this source of motion is investigated. Three-dimensional ultrasound images acquired on five patient prostates, before and after TRUS-probe-induced deformation, were registered using a nonrigid, surface-based method, and the accuracy of different deformation models compared. Registration using a statistical motion model was found to outperform alternative elastic deformation methods in terms of accuracy and robustness, and required substantially fewer target surface points to achieve a successful registration. The mean final target ...
A compression anastomosis ring (CAR) assembly for use in joining severed organ wall portions of a hollow organ. The assembly comprises a first portion which includes an anvil ring and a second portion which comprises a bottom ring, at least one ring element, and at least one spring element formed of a shape-memory alloy. The at least one spring element provides a restorative force and is in compressive force contact with the bottom ring and the tissue to be joined is positioned between the anvil ring and the bottom ring. A plurality of needles on one of the ring elements is operative, upon application of a closure force, to pierce the tissue and the anvil ring, holding the disk to the second portion of the CAR assembly. An applicator for applying the CAR assembly and a method for using the assembly and applicator are taught.
Mussel-Inspired Fabrication of Konjac Glucomannan/Poly (Lactic Acid) Cryogels with Enhanced Thermal and Mechanical Properties ...
Structure-Property Relationships of Cryogels Oguz Okay, Vla ... A Brief History of Polymeric Cryogels Vladmir I. Lozinsky Basic ... Rocco Di Girolamo Cryogels via UV Irradiation Technique Petar D. Petrov, Christo B. Tsvetanov Inorganic Cryogels Oleg A. ... Shlyakhtin Cryogels for Biotechnological Applications Bo Mattiasson Poly(vinyl alcohol) Cryogels for Biomedical Applications ... A Brief History of Polymeric Cryogels Vladmir I. Lozinsky Basic Principles of Cryotropic Gelation Vladimir I. Lozinsky, Oguz ...
... Lozinsky, Vladimir; Plieva, Fatima LU ; Galaev, Igor LU and Mattiasson, ... immobilization of ligands in cryogels and the application of affinity cryogels in bioseparation. Cryotropic gel formation ... immobilization of ligands in cryogels and the application of affinity cryogels in bioseparation. Cryotropic gel formation ... immobilization of ligands in cryogels and the application of affinity cryogels in bioseparation. Cryotropic gel formation ...
... Wim Van Camp UGent, Tuğba Dışpınar, ... "Chemical Modifications of Cryogels Verified Using High-resolution Mass NMR Spectroscopy." In Dresden Polymer Discussion, 12th, ... "Chemical Modifications of Cryogels Verified Using High-resolution Mass NMR Spectroscopy." Dresden Polymer Discussion, 12th, ... Van Camp W, Dışpınar T, Dervaux B, Du Prez F, Martins J, Fritzinger B. Chemical modifications of cryogels verified using high- ...
Çavuş A, Baysal Z, Alkan H (2013) Preparation of poly(hydroxyethyl methacrylate) cryogels containing l-histidine for insulin ... Lozinsky VI, Plieva FM, Galaev IY, Mattiasson B (2002) The potential of polymeric cryogels in bioseparation. Bioseparation. 10: ... The comparative investigation on synthesis, characterizations of silver ion-imprinting and non-imprinting cryogels, their ...
The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross ... The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross ... The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross ... Ciolacu, D, Rudaz, C, Vasilescu, M & Budtova, T 2016, Physically and chemically cross-linked cellulose cryogels: Structure, ...
This study suggested very low capacities of the cryogels for the protein due to low coupling sites on the matrix. Taking into ... Development of chromatographic bioseparations based on lectins and supermacroporous affinity cryogels. Raletjena, Moloko Ivonne ...
Feasibility of ceramic-polymer composite cryogels as scaffolds for bone tissue engineering. *Rodriguez-Lorenzo L ...
Biosurfactant Production by Pseudomonas aeruginosa BN10 Cells Entrapped in Cryogels. Christova, Nelly / Petrov, Petar / ...
46.Henderson, T.M.A., Ladewig, K., Haylock, D.N., McLean, K.M., and OConnor, A.J.: Cryogels for biomedical applications. J. ...
Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites ... Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites ... Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites ... Macroporous composite cryogels with embedded polystyrene divinylbenzene microparticles for the adsorption of toxic metabolites ...
Activated carbon cryogels and related methods. US20110002086 *. Jul 1, 2010. Jan 6, 2011. Feaver Aaron M. Ultrapure synthetic ... Activated carbon cryogels and related methods. US8797717. May 20, 2013. Aug 5, 2014. University Of Washington. Electrodes and ... Activated carbon cryogels and related methods. US8293818. Apr 8, 2010. Oct 23, 2012. Energ2 Technologies, Inc.. Manufacturing ...
Injectable nanocomposite cryogels for versatile protein drug delivery.. Koshy ST, Zhang DKY, Grolman JM, Stafford AG, Mooney DJ ... Injectable, Tough Alginate Cryogels as Cancer Vaccines.. Shih TY, Blacklow SO, Li AW, Freedman BR, Bencherif S, Koshy ST, ...
Hybrid alginate-based cryogels for life science applications Author(s): Barros, Alexandre António Antunes,Quraishi, Sakeena, ...
Activated carbon cryogels and related methods. US20110002086 *. 1 Jul 2010. 6 Ene 2011. Feaver Aaron M. Ultrapure synthetic ... Activated carbon cryogels and related methods. US8797717. 20 May 2013. 5 Ago 2014. University Of Washington. Electrodes and ... Activated carbon cryogels and related methods. US8293818. 8 Abr 2010. 23 Oct 2012. Energ2 Technologies, Inc.. Manufacturing ...
Adsorption of cellulase on poly(2-hydroxyethyl methacrylate) cryogels containing phenylalanine Authors: MURAT YAVUZ, OĞUZ ÇAKIR ...
Original Paper: Nano- and macroporous materials (aerogels, xerogels, cryogels, etc.). First Online: 25 April 2016. ...
Extracellular matrix-based cryogels for cartilage tissue engineering.. Han ME, Kim SH, Kim HD, Yim HG, Bencherif SA, Kim TI, ... Injectable Hyaluronic Acid-co-Gelatin Cryogels for Tissue-Engineering Applications.. Rezaeeyazdi M, Colombani T, Memic A, ...
2] Mattiasson, B. Cryogels for Biotechnological Applications. in Polymeric Cryogels (ed. Okay, O.) 245-281 (Springer Intnl Pub ... 1] Komarova, G. A. et al. Intelligent Gels and Cryogels with Entrapped Emulsions. Langmuir 24, 4467-4469 (2008). [ ... These chitosan derivatives cryogels exhibited loading ability, and the release of citral was pH- and temperature-dependent.. ... The pore size of the cryogels is around of 10 µm. The study of equilibrium swelling shows an abrupt decrement in water ...
Incorporation of decellularized extracellular matrix in cryogels for muscle regeneration (abstract). 10:00. Xutu Wang ( ...
Polymeric cryogels are biocompatible, and their biodegradation is independent of oxidative radicals ...
Reusability profile of the poly(AAm-GMA)-IDA-Cu$^{2+}$ cryogels was also studied and it was found that the synthesized cryogels ... Metal-chelated cryogels for amyloglucosidase adsorption: application for continuous starch hydrolysis. SINEM EVLI HANDE ORHAN ... Synthesized cryogels were characterized by FTIR, SEM and EDX studies. Pore diameter of the whole polymeric structure was 3-10 ... Poly(AAm-GMA) cryogels were used as structural elements, whileGMA monomer served reactive epoxy groups for IDA immobilization. ...
"Chapter 16 Direct Capture of His6-Tagged Proteins Using Megaporous Cryogels Developed for Metal-Ion Affinity Chromatography" ...
Correlation between cryogenic parameters and physico-chemical properties of porous gelatin cryogels Sandra Van Vlierberghe ( ...
  • Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. (edu.kz)
  • This can be overcome by the development of composite cryogels. (rian.ie)
  • In this study, PVA/Biomacromolecule composite cryogels were produced with a two step physical crosslinking (cryogelation and coagulation bath treatment) in the presence of different additives and a novel procedure to produce cell encapsulated PVA cryogels was developed for vascular tissue engineering. (rian.ie)
  • Interconnected systems of macropores and sponge-like morphology are typical for cryogels, allowing unhindered diffusion of solutes of practically any size. (lu.se)
  • These cryogels also exhibited good in vitro degradation capacity at 37 °C within 4 weeks of incubation. (hindawi.com)
  • These injectable cryogels will be especially useful for a number of clinical applications including cell therapy, tissue engineering, dermal filler in cosmetics, drug delivery, and scaffold-based immunotherapy, says Bencherif. (nanowerk.com)
  • This is a review discussing the production and properties of cryogels (from the Greek κριoσ (kryos) meaning frost or ice), immobilization of ligands in cryogels and the application of affinity cryogels in bioseparation. (lu.se)
  • article{83697e11-578b-49d7-a3be-c17fd175392b, abstract = {This is a review discussing the production and properties of cryogels (from the Greek κριoσ (kryos) meaning frost or ice), immobilization of ligands in cryogels and the application of affinity cryogels in bioseparation. (lu.se)
  • The invention provides cryogels whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a. (patents.com)
  • Cryogels are characterized by very broad pore size distribution from nanometers to hundreds of micrometers. (science-community.org)
  • In this study carrageenan-gelatin (natural polymers) cryogels were synthesized by using glutaraldehyde and 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride and N -hydroxysuccinimide (EDC-NHS) as crosslinking agent at optimum concentrations. (hindawi.com)
  • Most of the water present in spongy cryogels is capillary bound and can be removed mechanically by squeezing. (lu.se)
  • Unconfined compression analysis showed elasticity and physical integrity of all cryogels, as these matrices regained their original length after 90% compressing from the original size. (hindawi.com)
  • Cryogels are characterized by high biocompatibility due to the use of biopolymeric or protein matrices. (science-community.org)
  • This study suggested very low capacities of the cryogels for the protein due to low coupling sites on the matrix. (ul.ac.za)
  • The properties of cryogels can be regulated by the temperature of cryogelation, the time the sample is kept in a frozen state and freezing/thawing rates, by the nature of the solvent and by the use of soluble and insoluble additives. (lu.se)
  • We studied the biomimetic synthesis of polyaniline as an alternate route to prepare electrical conductive cryogels (ECC), unique structures that combine intrinsic conductivity and hydrogel properties. (techconnect.org)
  • As chromatographic materials, cryogels can be used both in bead form and as spongy cylindrical blocks (monoliths) synthesized inside the chromatographic column. (lu.se)
  • However PVA cryogels are not suitable for cell attachment and proliferation alone. (rian.ie)
  • New potential applications of cryogels are discussed. (lu.se)
  • Van Camp W, Dışpınar T, Dervaux B, Du Prez F, Martins J, Fritzinger B. Chemical modifications of cryogels verified using high-resolution mass NMR spectroscopy. (ugent.be)
  • Cryogels can be obtained through the formation of both physically and covalently cross-linked heterogeneous polymer networks. (lu.se)
  • A team of researchers led by Dr. Friederike J. Gruhl and Professor Andrew C. B. Cato at Karlsruhe Institute of Technology (KIT) are developing a three-dimensional model for prostate cancer research based on cryogels. (scienceandtechnologyresearchnews.com)
  • The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. (aalto.fi)
  • Cryogels can absorb large amounts of water and characterized controlled swelling degree. (science-community.org)
  • Al-Lohedan, H. The resourcefulness of p(4-VP) cryogels as template for in situ nanoparticle preparation of various metals and their use in H 2 production, nitro compound reduction and dye degradation. (alfa.com)