Cryogels

Chitosan

Gelatin

Tissue Scaffolds

Liver support system

Polyelectrolyte

Polyethylenimine

Affinity chromatography

Chromatography

Dye-ligand affinity chromatography

Cellulose based cryogels1

• We found that gelatin and cellulose based cryogels mechanically outperform other biopolymer composites while having a homogeneous micro-structure and high stiffness-to-weight ratio. (authorea.com)

Macroporous cryogels2

• Here we encapsulate GM-CSF, serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like macroporous cryogels. (harvard.edu)
• Lidgren L., Tägil M., Kumar A. Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. (lu.se)

Scaffolds1

• Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. (hacettepe.edu.tr)

Injectability1

• Here, covalent and ionic crosslinking of cryogels are combined with the hypothesis that this will result in a tough MA‐alginate cryogel with improved injectability. (nsf.gov)

Mechanically1

• Although cryogelation reactions and cryogels were discovered more than 70 years ago, they attracted significant interest only in the last 20 years mainly due to their extraordinary properties compared to the classical hydrogels such as a high toughness, almost complete squeezability, a mechanically stable porous structure with honeycomb arrangement, poroelasticity, and fast responsivity against external stimuli. (tubitak.gov.tr)

Porous structure2

• The molar ratio of solvent/precursor, which was varied from 5 to 13, significantly affected the porous structure and thermal insulating properties of the cryogels. (elsevierpure.com)
• F. Topuza, T. Uyara, Poly-cyclodextrin cryogels with aligned porous structure for removal of polycyclic aromatic hydrocarbons (PAHs) from water, J. Hazard. (deswater.com)

Composite2

• In this work, we highlight a manufacturing framework and material selection process featuring biopolymer-based, high-strength composite cryogels and printed carbon-based electronics for transient drones. (authorea.com)
• In this work, composite materials based on cryogels of polyvinyl alcohol and calcium phosphates have been obtained, and the phase composition of materials has been studied depending on the conditions for their preparation. (tsu.ru)

Minimally invasive2

• These cryogels can be delivered in a minimally invasive manner, bypass the need for genetic modification of transplanted cancer cells and provide sustained release of immunomodulators. (harvard.edu)
• The MA‐alginate tough cryogels provide a promising minimally invasive delivery platform for cancer vaccinations. (nsf.gov)

Spongy1

• The cryogels synthesized in freezing conditions provided spongy, elastic and supermacroporous character as compared to the hydrogels synthesized at ambient temperatures. (syr.edu)

Supermacroporous1

• The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. (hacettepe.edu.tr)

Gels2

• Granulocyte macrophage colony‐stimulating factor releasing tough cryogels recruit four times more DCs than blank gels by day 7 in vivo. (nsf.gov)
• Our earlier observations revealed that the elastic deformation of cryogels either by external forces (mechanical deformation) or internal forces (shrinkage-swelling of poly(NiPAAm) cryogels) led to detachment of affinity bound bioparticles to these gels, which promises great potential in understanding cell interactions on elastic matrices [M.B. Dainiak, A. Kumar, I.Y. Galaev, B. Mattiasson, Proc. (syr.edu)

Gelatin2

• Our results demonstrate how gelatin-cellulose cryogels can be used to manufacture lightweight transient drones while printing carbon conductive electronics is a viable method for designing sustainable, integrated sensors. (authorea.com)
• In the present research, we fabricated cryogels consisting of methacrylated gelatin, methacrylated hyaluronic acid, and 4arm poly(ethylene glycol) acrylate (PEG-4A) by using cryopolymerization. (desktopmetal.com)

Poly3

• Poly(N-isopropylacrylamide) [poly(NiPAAm)] and poly(acrylamide) [poly(AAm)] cryogels were synthesized by radical polymerization at -12 °C for 12 h using monomers of N-isopropylacrylamide (NiPAAm) and acrylamide (AAm) with N,N-methylene bisacrylamide (MBAAm) as cross-linking agent, respectively. (syr.edu)
• The deformation characteristic of cryogels as measured by Young's modulus indicates that the modulus of elasticity of poly(NiPAAm) cryogel (33-65 kPa) is comparatively lower than the Young's modulus for poly(AAm) cryogel (42-86 kPa). (syr.edu)
• Further, the swelling/de-swelling kinetics study on poly(NiPAAm) cryogel and hydrogel showed, higher swelling ratios for cryogels in the range of 13-16 as compared to poly(NiPAAm) hydrogels which were in the range of 7-10. (syr.edu)

Thermal1

• The silica cryogels with low densities in the range of 0.08-0.18gcm 3 and thermal conductivities as low as 6.7mW(m·K) 1 at 100Pa and 28.3mW(m·K) 1 at 10 5 Pa were obtained using this new technique. (elsevierpure.com)

Properties3

• In this mini review, general properties of cryogelation systems including the cryoconcentration phenomenon responsible for the unique properties of the cryogels are discussed. (tubitak.gov.tr)
• Cryogelation reactions conducted within the pores of preformed cryogels and some novel cryogels with attractive properties are then discussed in the last section. (tubitak.gov.tr)
• The macroporous monolithic pAAm-cryogels columns present attractive chromatographic media with unique properties like extremely low flow resistance. (lu.se)

Potential1

• Altogether, these findings indicate the potential for cryogels to serve as a platform for cancer cell vaccinations. (harvard.edu)

Bone1

• Generation of bone grafts using cryopreserved mesenchymal stromal cells and macroporous collagen-nanohydroxyapatite cryogels. (in.ua)

Found1

• The Young's modulus of both the cryogels was found to be dependent on monomer concentration in cryogels and increases with the increase in concentration. (syr.edu)

Cells2

• These cryogels are injected subcutaneously into mice to localize transplanted tumour cells and deliver immunomodulatory factors in a controlled spatio-temporal manner. (harvard.edu)
• Cytosine‐phosphodiester‐guanine (CpG)‐delivering tough cryogels effectively activate dendritic cells (DCs). (nsf.gov)

Supermacroporous cryogels2

• In this article, ion imprinted poly(hydroxyethyl methacrylate) (PHEMA) based supermacroporous cryogels were synthesized in the presence of a functional monomer, namely N-methacryloyl-histidine methyl ester (MAH), to be complexed with Ni(II) ions. (uludag.edu.tr)
• The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. (hacettepe.edu.tr)

Macroporous1

• Lidgren L., Tägil M., Kumar A. Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. (lu.se)

Hydrogels5

• The large-pore interconnected channels in cryogels, allow convectional flow and rapid mass-transport of solute constituents between the solution and cryogel polymer framework, as compared to slower, diffusionally-controlled mass-transport in small-pore hydrogels. (huji.ac.il)
• These features are applied to develop enzyme-loaded polyacrylamide (pAAm) cryogels, and glucose oxidase (GOx)-loaded pH-responsive DNA-based pAAm cryogels, revealing enhanced biocatalytic transformations, enhanced temporal stiffness changes, and mechanical bending functions, as compared to analog hydrogels. (huji.ac.il)
• Enhanced switchable stiffness changes of DNA-based pAAm cryogels, as compared to analog hydrogels, are demonstrated upon subjecting the cryogel/hydrogel matrices to auxiliary pH-changes, or by integration of GOx into the frameworks, and driving pH-changes through GOx-catalyzed aerobic oxidation of glucose to gluconic acid. (huji.ac.il)
• The increased cross-linking rate and spatial condensation in the cryogels provide unique wall and pore structures, which result in elastic, spongelike hydrogels. (tissueandcells.com)
• The moduli of the cryogels prepared by glycol-chitosan-catechol (g-chitosan-c) were improved by 3-6-fold compared to room temperature-cured conventional hydrogels, and the degree of improvement increased depending on the freezing time and the number of freeze-thawing cycles. (tissueandcells.com)

Synthesis1

• Research completed under his direction includes calculation of aluminum diffusion in silicate glasses to predict grain boundary chemistry, mathematical modeling of colloidal particle interactions and particle packing in various mediums, the development of cermets through freeze-casting techniques, synthesis of polymeric cryogels, and finite element analysis of chemical reactions in various high temperature reactors. (ceramics.org)

Matrices1

• Enhanced stiffness changes of pAAm cryogels represent a major advance to control the mechanical properties of cryogels and are attributed to the convectionally-controlled mass-transport in the cryogel matrices. (huji.ac.il)

Bilayer1

• Moreover, bilayer constructs consisting of poly-N-isopropylacrylamide (pNIPAM) cryogels and pH-responsive DNA-based pAAm cryogel or hydrogel structures are constructed. (huji.ac.il)

Elastic1

• As a result of the studies, it was found that the melting temperature and elastic modulus of HA-PVA composite cryogels are affected not only by the concentration of the polymer component, but also by the time of mixing the reaction mixture. (tsu.ru)

Tissue4

• Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction. (nvcg.nl)
• Cryogels have pores that are produced by growing ice crystals and have been developed with a tissue-like elasticity that is suitable for cell immunization experiments. (nih.gov)
• We further show that cryogels can deliver tetrodotoxin to tissue, inhibiting neuronal function in a reversible manner. (devneuro.org)
• These easy-to-use cryogels offer an innovate approach for more complex manipulations of ex-vivo tissue. (devneuro.org)

Removal1

• Ni(II) imprinted cryogels exhibited excellent selectivity toward competitive metal ions [Fe(III), Cu(II) and Zn(II)] indicating important potential for selective removal of Ni(II) ions from aqueous solutions. (uludag.edu.tr)