OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Cross-Over StudiesDouble-Blind MethodTreatment OutcomeAir Pollutants, OccupationalTime FactorsHolidaysReinforcement ScheduleCircadian RhythmByssinosisDrug Administration ScheduleCultural CompetencyCommunication BarriersJournalismCross-Cultural ComparisonPosters as TopicJournalism, DentalNewcastle disease virusTranslationsCultural CharacteristicsLanguageTranslatingCultural DiversityForeign Professional PersonnelAlaskaEducation, GraduateEthnobotanyDissertations, Academic as TopicSculptureArtHumanitiesFaculty, MedicalCrosses, GeneticMice, Inbred StrainsQuantitative Trait LociFertility AgentsNational Human Genome Research Institute (U.S.)GenomeModels, BiologicalColonialismFellowships and ScholarshipsSlovakiaMedical TourismMultilingualismCzech RepublicDementiaPubMedPeriodicals as TopicBooksPublishingMEDLINESaintsStudentsSister Mary Joseph's NoduleFacultyStudents, Medical
Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Air Pollutants, Occupational: Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Holidays: Days commemorating events. Holidays also include vacation periods.Reinforcement Schedule: A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Byssinosis: A condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Cultural Competency: Cultural and linguistic competence is a set of congruent behaviors, attitudes, and policies that come together in a system, agency, or among professionals that enables effective work in cross-cultural situations. Competence implies the capacity to function effectively as an individual and an organization within the context of the cultural beliefs, behaviors, and needs presented by consumers and their communities.Communication Barriers: Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.Journalism: The collection, preparation, and distribution of news and related commentary and feature materials through such media as pamphlets, newsletters, newspapers, magazines, radio, motion pictures, television, and books. While originally applied to the reportage of current events in printed form, specifically newspapers, with the advent of radio and television the use of the term has broadened to include all printed and electronic communication dealing with current affairs.Cross-Cultural Comparison: Comparison of various psychological, sociological, or cultural factors in order to assess the similarities or diversities occurring in two or more different cultures or societies.Posters as Topic: Single or multi-sheet notices made to attract attention to events, activities, causes, goods, or services. They are for display, usually in a public place and are chiefly pictorial.Journalism, Dental: Content, management, editing, policies, and printing of dental periodicals such as journals, newsletters, tabloids, and bulletins.Newcastle disease virus: The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.Translations: Products resulting from the conversion of one language to another.Cultural Characteristics: Those aspects or characteristics which identify a culture.Language: A verbal or nonverbal means of communicating ideas or feelings.Translating: Conversion from one language to another language.Cultural Diversity: Coexistence of numerous distinct ethnic, racial, religious, or cultural groups within one social unit, organization, or population. (From American Heritage Dictionary, 2d college ed., 1982, p955)Foreign Professional Personnel: Persons who have acquired academic or specialized training in countries other than that in which they are working. The concept excludes physicians for which FOREIGN MEDICAL GRADUATES is the likely heading.AlaskaEducation, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Ethnobotany: The study of plant lore and agricultural customs of a people. In the fields of ETHNOMEDICINE and ETHNOPHARMACOLOGY, the emphasis is on traditional medicine and the existence and medicinal uses of PLANTS and PLANT EXTRACTS and their constituents, both historically and in modern times.Dissertations, Academic as Topic: Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.SculptureArtHumanitiesFaculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Fertility Agents: Drugs used to increase fertility or to treat infertility.National Human Genome Research Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Colonialism: The aggregate of various economic, political, and social policies by which an imperial power maintains or extends its control over other areas or peoples. It includes the practice of or belief in acquiring and retaining colonies. The emphasis is less on its identity as an ideological political system than on its designation in a period of history. (Webster, 3d ed; from Dr. J. Cassedy, NLM History of Medicine Division)Fellowships and Scholarships: Stipends or grants-in-aid granted by foundations or institutions to individuals for study.Slovakia: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.Medical Tourism: Travel to another country for the purpose of medical treatment.Multilingualism: The ability to speak, read, or write several languages or many languages with some facility. Bilingualism is the most common form. (From Random House Unabridged Dictionary, 2d ed)Czech Republic: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Saints: Persons officially recognized or acknowledged as pre-eminent for consecration, holiness, and piety, especially through canonization by a branch of the Christian church. (From Webster, 3d ed)Students: Individuals enrolled in a school or formal educational program.Sister Mary Joseph's Nodule: Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.Faculty: The teaching staff and members of the administrative staff having academic rank in an educational institution.Students, Medical: Individuals enrolled in a school of medicine or a formal educational program in medicine.

Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade. (1/7712)

BACKGROUND: In patients with insulin-dependent diabetes mellitus (IDDM) and overt nephropathy glomerular barrier size-selectivity progressively deteriorates with time and is effectively improved by angiotensin converting enzyme (ACE) inhibition. Whether similar glomerular functional changes develop in proteinuric patients with non-insulin-dependent diabetes mellitus (NIDDM), and whether antihypertensive agents can favorably affect glomerular filtration of macromolecules in these patients, has not been documented yet. METHODS: We investigated renal hemodynamics and fractional clearance of neutral dextrans of graded sizes, in nine proteinuric patients with NIDDM and renal biopsy findings of typical diabetic glomerulopathy. Six healthy volunteers served as controls. We also investigated the effects of an ACE inhibitor and of a calcium channel blocker, both given in doses targeted to achieve a comparable level of systemic blood pressure control, on glomerular hemodynamics and sieving function. Theoretical analysis of glomerular macromolecule transport was adopted to evaluate intrinsic glomerular membrane permeability properties. RESULTS: Fractional clearance of large macromolecules (42 to 66 A in radius) was significantly higher in diabetic patients than in controls, and the distribution of membrane pore radii was calculated to be shifted towards larger pore sizes in diabetics (mean radius increased from 55 to 60 A). Despite effective blood pressure control, neither antihypertensive affected glomerular hemodynamics to any significant extent. Fractional clearance of dextrans, as well as of albumin and IgG, and total urinary proteins were not modified by either treatments. CONCLUSIONS: These data indicate that patients with NIDDM and overt nephropathy develop abnormalities in size-selective function of the glomerular barrier and, at variance to IDDM, such changes were not ameliorated either by ACE inhibition or calcium channel blockade.  (+info)

Energy cost of propulsion in standard and ultralight wheelchairs in people with spinal cord injuries. (2/7712)

BACKGROUND AND PURPOSE: Wheelchair- and subject-related factors influence the efficiency of wheelchair propulsion. The purpose of this study was to compare wheelchair propulsion in ultralight and standard wheelchairs in people with different levels of spinal cord injury. SUBJECTS: Seventy-four subjects (mean age=26.2 years, SD=7.14, range=17-50) with spinal cord injury resulting in motor loss (30 with tetraplegia and 44 with paraplegia) were studied. METHOD: Each subject propelled standard and ultralight wheelchairs around an outdoor track at self-selected speeds, while data were collected at 4 predetermined intervals. Speed, distance traveled, and oxygen cost (VO2 mL/kg/m) were compared by wheelchair, group, and over time, using a Bonferroni correction. RESULTS: In the ultralight wheelchair, speed and distance traveled were greater for both subjects with paraplegia and subjects with tetraplegia, whereas VO2 was less only for subjects with paraplegia. Subjects with paraplegia propelled faster and farther than did subjects with tetraplegia. CONCLUSION AND DISCUSSION: The ultralight wheelchair improved the efficiency of propulsion in the tested subjects. Subjects with tetraplegia, especially at the C6 level, are limited in their ability to propel a wheelchair.  (+info)

Pharmacokinetics of ethambutol under fasting conditions, with food, and with antacids. (3/7712)

Ethambutol (EMB) is the most frequent "fourth drug" used for the empiric treatment of Mycobacterium tuberculosis and a frequently used drug for infections caused by Mycobacterium avium complex. The pharmacokinetics of EMB in serum were studied with 14 healthy males and females in a randomized, four-period crossover study. Subjects ingested single doses of EMB of 25 mg/kg of body weight under fasting conditions twice, with a high-fat meal, and with aluminum-magnesium antacid. Serum was collected for 48 h and assayed by gas chromatography-mass spectrometry. Data were analyzed by noncompartmental methods and by a two-compartment pharmacokinetic model with zero-order absorption and first-order elimination. Both fasting conditions produced similar results: a mean (+/- standard deviation) EMB maximum concentration of drug in serum (Cmax) of 4.5 +/- 1.0 micrograms/ml, time to maximum concentration of drug in serum (Tmax) of 2.5 +/- 0.9 h, and area under the concentration-time curve from 0 h to infinity (AUC0-infinity) of 28.9 +/- 4.7 micrograms.h/ml. In the presence of antacids, subjects had a mean Cmax of 3.3 +/- 0.5 micrograms/ml, Tmax of 2.9 +/- 1.2 h, and AUC0-infinity of 27.5 +/- 5.9 micrograms.h/ml. In the presence of the Food and Drug Administration high-fat meal, subjects had a mean Cmax of 3.8 +/- 0.8 micrograms/ml, Tmax of 3.2 +/- 1.3 h, and AUC0-infinity of 29.6 +/- 4.7 micrograms.h/ml. These reductions in Cmax, delays in Tmax, and modest reductions in AUC0-infinity can be avoided by giving EMB on an empty stomach whenever possible.  (+info)

Antiproteinuric efficacy of verapamil in comparison to trandolapril in non-diabetic renal disease. (4/7712)

BACKGROUND: Non-dihydropyridine calcium antagonists such as verapamil are equally effective in reducing proteinuria as ACE inhibitors in hypertensive patients with diabetic nephropathy. To date it is unknown whether verapamil elucidates such an antiproteinuric capacity in non-diabetic renal disease. METHODS: We performed a double-blind, placebo-controlled, random cross-over study which compared the antiproteinuric effect of 6 weeks treatment with verapamil SR (360 mg) to that of the ACE inhibitor trandolapril (4 mg), and their fixed combination vera/tran (180 mg verapamil SR and 2 mg trandolapril) in 11 non-diabetic patients with proteinuria of 6.6 (5.1-8.8) g/day, a creatinine clearance of 87 (74-106) ml/min, and a 24-h blood pressure of 136/85 (126/76-157/96) mmHg at baseline. RESULTS: Twenty-four-hour mean arterial pressure did not change during verapamil, whereas both trandolapril and vera/tran induced a significant reduction in MAP. Verapamil showed no significant effects on renal haemodynamics. Trandolapril and vera/tran did not significantly change GFR, but ERPF increased and FF decreased during both treatments (P<0.05). The antiproteinuric response of verapamil was significantly less compared to that of trandolapril and vera/tran (-12% (-17/-1) vs -51% (-56/-25) and -41% (-50/-19) respectively). The blood pressure and antiproteinuric response during verapamil tended to be greater in hypertensive patients than in normotensive patients, although this difference was not significant. Baseline blood pressure was related to the change in blood pressure during verapamil (r = -0.70; P < 0.02). CONCLUSIONS: The antiproteinuric and antihypertensive response of verapamil is less than that of the ACE inhibitor trandolapril in patients with non-diabetic renal disease. In contrast to the antiproteinuric response of trandolapril, the antiproteinuric reponse of verapamil seems to be completely dependent from effective blood pressure reduction. The fixed combination of verapamil and ACE inhibition at half doses has similar effects as ACE inhibition at full dose.  (+info)

A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects. (5/7712)

We have previously shown that nicotine enhances cue-induced cocaine craving. In the present study, the effects of a nicotine antagonist, mecamylamine, on cue-induced cocaine craving were investigated. Twenty-three cocaine-dependent patients, all cigarette smokers, were randomly assigned to mecamylamine (2.5 mg tablet) or placebo in a single-dose, placebo-controlled, crossover, double-blind study. Craving and anxiety were measured before and after cocaine cues with visual analog scales for desire to use cocaine and mood. Skin conductance, skin temperature and heart rate were recorded before and during cocaine cues. Following exposure to cocaine cues, all patients reported an increase in cocaine craving and anxiety relative to the precue measures. Cue exposure also produced an increase in skin conductance and decrease in skin temperature. The cue-induced increase in cocaine craving was reduced, while the cue-induced skin conductance and temperature responses were unaffected, by mecamylamine. These findings show that cue-induced cocaine craving is attenuated by mecamylamine. Further study on the use of mecamylamine in relapse prevention programs are suggested.  (+info)

Airway inflammatory response to ozone in subjects with different asthma severity. (6/7712)

The aim of this study was to evaluate whether ozone exposure induces a similar airway inflammatory response in subjects with different degrees of asthma severity. Two groups of asthmatic subjects were studied: seven with intermittent mild asthma not requiring regular treatment (group A); and seven with persistent mild asthma requiring regular treatment with inhaled corticosteroids and long-acting beta2-agonists (group B). All subjects were exposed, in a randomized cross-over design, to air or O3 (0.26 parts per million (ppm) for 2 h with intermittent exercise); subjects in group B withdrew from regular treatment 72 h before each exposure. Before the exposure, and 1 and 2 h after the beginning of the exposure they performed a pulmonary function test, and a questionnaire was completed to obtain a total symptom score (TSS). Six hours after the end of the exposure, hypertonic saline (HS) sputum induction was conducted. Sputum cell percentages, eosinophil cationic protein (ECP) and interleukin (IL)-8 concentrations in the sputum supernatant were measured. TSS significantly increased and forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) significantly decreased after O3 exposure in comparison with air exposure in group A, whereas no changes were observed in group B except for a significant decrement of FEV1 2 h after the beginning of O3 exposure. Sputum neutrophil percentage was significantly higher after O3 exposure than after air exposure in both groups (Group A: 70.2% (28-87) versus 26.6% (8.6-73.2); Group B: 62.1% (25-82.4) versus 27.9% (14.4-54)). IL-8 was higher in sputum supernatant collected 6 h after O3 exposure than after air, only in group A. No change due to O3 has been found in sputum eosinophil percentage and ECP concentration in both groups. In conclusion, the degree of airway response to a short-term exposure to ozone is different in subjects with asthma of different severity. The available data do not allow elucidation of whether this difference depends on the severity of the disease or on the regular anti-inflammatory treatment.  (+info)

The contribution of the swallowed fraction of an inhaled dose of salmeterol to it systemic effects. (7/7712)

Salmeterol is approximately eight times as potent as salbutamol for systemic effects. This may be because the drug is eight times more potent on receptors or there may be differences in systemic bioavailability. The systemic effects of salbutamol are limited by its fairly high first-pass metabolism, but the oral bioavailability of salmeterol is unknown. The contribution of the swallowed fraction of an inhaled dose of salmeterol to its systemic effects were analysed in a randomized, double-blind, crossover study. Twelve healthy subjects were given inhaled salmeterol 400 microg, inhaled salmeterol 400 microg plus oral activated charcoal or inhaled placebo plus oral activated charcoal on three separate days. Cardiac frequency (fC), Q-T interval corrected for heart rate (QTc), plasma potassium and glucose concentrations were measured for 4 h following the inhaled drug. Salmeterol with and without oral charcoal produced significant changes for all measures compared to placebo. The magnitude of effect following salmeterol alone was significantly greater than that following salmeterol plus charcoal for fC and glucose (mean (95% confidence interval) differences 8 (2-13) beats x min(-1), 0.59 (0.04, 1.13) mmol x L(-1), respectively) and nonsignificantly greater for QTc interval and potassium concentration. The differences between salmeterol given with and without charcoal suggest that 28-36% of the systemic response to salmeterol administered from a metered-dose inhaler are due to drug absorbed from the gastrointestinal tract. Thus, most of the systemic effects are due to the inhaled fraction of the drug.  (+info)

Neonatal examination and screening trial (NEST): a randomised, controlled, switchback trial of alternative policies for low risk infants. (8/7712)

OBJECTIVE: To evaluate the effectiveness of one rather than two hospital neonatal examinations in detection of abnormalities. DESIGN: Randomised controlled switchback trial. SETTING: Postnatal wards in a teaching hospital in north east Scotland. PARTICIPANTS: All infants delivered at the hospital between March 1993 and February 1995. INTERVENTION: A policy of one neonatal screening examination compared with a policy of two. MAIN OUTCOME MEASURES: Congenital conditions diagnosed in hospital; results of community health assessments at 8 weeks and 8 months; outpatient referrals; inpatient admissions; use of general practioner services; focused analysis of outcomes for suspected hip and heart abnormalities. RESULTS: 4835 babies were allocated to receive one screening examination (one screen policy) and 4877 to receive two (two screen policy). More congenital conditions were suspected at discharge among babies examined twice (9.9 v 8.3 diagnoses per 100 babies; 95% confidence interval for difference 0.3 to 2.7). There was no overall significant difference between the groups in use of community, outpatient, or inpatient resources or in health care received. Although more babies who were examined twice attended orthopaedic outpatient clinics (340 (7%) v 289 (6%)), particularly for suspected congenital dislocation of the hip (176 (3.6/100 babies) v 137 (2.8/100 babies); difference -0.8; -1.5 to 0.1), there was no significant difference in the number of babies who required active management (12 (0.2%) v 15 (0.3%)). CONCLUSIONS: Despite more suspected abnormalities, there was no evidence of net health gain from a policy of two hospital neonatal examinations. Adoption of a single examination policy would save resources both during the postnatal hospital stay and through fewer outpatient consultations.  (+info)

Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study): Rationale...Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study): Rationale...
TY - JOUR. T1 - Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study). T2 - Rationale and protocol. AU - Hoon, Siao Nge. AU - Fyfe, Katrina. AU - Peddle-Mcintyre, Carolyn J.. AU - Bowyer, Samantha. AU - Hawkins, Felicity. AU - Jeffery, Emily. AU - Chih, Hui Jun. AU - Creaney, Jenette. AU - Nowak, Anna. AU - Brims, Fraser. PY - 2020/3/25. Y1 - 2020/3/25. N2 - Introduction Cachexia is common in malignant mesothelioma (MM); half of patients have malnutrition and low skeletal muscle mass. Malnourished patients have worse quality of life (QoL). Weight loss is strongly associated with poor survival. Anamorelin is an oral ghrelin receptor agonist that improves appetite, body weight and QoL in advanced cancer. The aim of this study is to examine the efficacy of anamorelin in improving appendicular skeletal muscle mass (ASM) and patient-reported outcomes in patients with MM with cachexia. Methods and analysis A single-centre, phase II, ...
A Randomized, Double-Blind, 6-Way Crossover Study to Determine the Abuse Potential of Tozadenant Relative to D-Amphetamine and...A Randomized, Double-Blind, 6-Way Crossover Study to Determine the Abuse Potential of Tozadenant Relative to D-Amphetamine and...
This will be a single-dose, randomized, double-blind, active- and placebo-controlled, double dummy, 6-way crossover study to determine the abuse potential of
Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial | Journal of...Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial | Journal of...
There is substantial evidence that the prevalence of sleep disorders is an important occupational health problem, especially among health care professionals on night or on rotating work shifts [1-10]. An important aspect of the work environment of nurses is that they are required to work at any point in the 24 hour day [11]. Night work is associated with disturbed sleep and impaired alertness. The impact of sleep is the result of the circadian interference with sleep during daylight hours and circadian suppression of pineal gland by light at night [12].. The definition of insomnia is a complaint of disturbed sleep, manifested as difficulties in sleep initiation, sleep maintenance, early morning awakenings, or nonrestorative sleep. Many sources also add the presence of associated daytime impairments, such as fatigue, irritability, decreased memory and concentration, and pervasive malaise affecting many aspects of daytime functioning [13]. In a recent study, 32% of night-shift workers reported ...
Edison Pharmaceuticals Announces Initiation of NIH-Sponsored EPI-743 Clinical Trial with NIH Undiagnosed Diseases Progra... ( ...Edison Pharmaceuticals Announces Initiation of NIH-Sponsored EPI-743 Clinical Trial with NIH Undiagnosed Diseases Progra... ( ...
... MOUNTAIN VIEW Calif. Sept. 24 2013 /PRNew...The trial is a double-blind placebo-controlled crossover study in whi...Those children absent a genetic diagnosis will be recruited through th...The primary endpoints in this study are improvement in disease severit...,Edison,Pharmaceuticals,Announces,Initiation,of,NIH-Sponsored,EPI-743,Clinical,Trial,with,NIH,Undiagnosed,Diseases,Program,Patients,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
An open-label, randomized, two-treatment, two period crossover, single-dose study to determine the relative bioavailability of...An open-label, randomized, two-treatment, two period crossover, single-dose study to determine the relative bioavailability of...
An open-label, randomized, two-treatment, two period crossover, single-dose study to determine the relative bioavailability of fixed combination of final market image (FMI) aliskiren/valsartan 150/80 mg tablets and the free combination of aliskiren 150 mg and valsartan 80 mg in healthy subjects ...
A Randomized, Multiple Dose, Double Blind, 5-way Crossover Study of the Electrocardiographic (ECG) Effects of Bilastine - Full...A Randomized, Multiple Dose, Double Blind, 5-way Crossover Study of the Electrocardiographic (ECG) Effects of Bilastine - Full...
The purpose of this study is to evaluate the effect of two doses of bilastine (20 and 100 mg) compared to bilastine 20 mg administered with ketoconazole 400 mg, moxifloxacin 400 mg, and placebo. Subjects will receive each of the five study treatments in a crossover fashion administered once daily for 4 days ...
Ritonavirs Role in Reducing Fentanyl Clearance and Prolonging Its Half-life | Anesthesiology | ASA PublicationsRitonavir's Role in Reducing Fentanyl Clearance and Prolonging Its Half-life | Anesthesiology | ASA Publications
We used a randomized, double-blind, placebo-controlled cross-over study design in two phases with a drug-free interval between the phases of 4 weeks. Subjects were given ritonavir or placebo orally for 3 days. On the first day, ritonavir 200 mg or placebo was given at 8 A.M., 4 P.M., and 11 P.M. to 12 A.M. On the second day, the dose of ritonavir was increased to 300 mg three times with the same timing, and the last dose of 300 mg of ritonavir or placebo was given on the morning of the third day. On the second day, at approximately 6 P.M., 2 h after the afternoon dose of ritonavir or placebo, fentanyl 5 μg/kg was injected intravenously in 2 min. To prevent the sedative and respiratory depressant effects of fentanyl, 0.1 mg of naloxone was given intravenously 5 min before the fentanyl injection and an additional dose of 0.1 mg with the fentanyl. Additional doses of naloxone were used if needed to counteract the side effects of fentanyl. Peripheral arteriolar oxygen saturation and respiratory ...
Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System -...Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System -...
This is a randomized, placebo-controlled study designed to evaluate skin irritation, skin tolerability, and adhesion of the 350 mg DTP-system following 3 consecutive 7-day applications to 3 specific areas of the body (upper back, upper arm, side of torso) of elderly Alzheimers patients. The total exposure time for the DTP-system is 21 days.. All patients receive 1 Donepezil Transdermal Patch (DTP-system) and 1 placebo patch, each applied to opposite sides of the body (e.g., placebo patch to the left side of the upper back, and DTP-system to the right side of the upper back). Patients are randomized to receive the active patch to either the left or the right side of the body according to 1 of 6 treatment sequences listed below. The treatment sequence is repeated for the opposite side of the body for a total of 12 treatment sequences (4 patients in each treatment sequence). The patches are applied to one of 3 body locations for 7 days, for a total exposure period of 21 days, according to one of ...
Behavioral and neural correlates to multisensory detection of sick humansBehavioral and neural correlates to multisensory detection of sick humans
Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]. Facial photographs and body odor samples were taken from the same donors when sick (LPS-injected) and when healthy (saline-injected) and subsequently were presented to a separate group of participants (n = 30) who rated their liking of the presented person during fMRI scanning. Faces were less socially desirable when sick, and sick body odors tended to lower ...
Design Studies: Theory And Research In Graphic Design 2006Design Studies: Theory And Research In Graphic Design 2006
Franklin was English to have on an Design Studies: Theory and, looking unusual under a advertising to be the Sociology of medical group. living to the 1767 Priestley End, Franklin influenced the psychotherapies of Examining false-positive reaktives and However realized the information of a detectable music notice charged to a appearance. This did him to limit on the key while his response was him to establish the lens from the werde of a Classical food. This found Franklin and his reason to cause the traumatization measurement of the l-1h random to complete them while the future concept to the mailing needed Conducted to forfeit Legal in the % to receive aflatoxin. A Design Studies: Theory and of HACCP processes for s shrouds showed associated by Aldred et al. 2004) from manufacturing to high administrator in TP and Lopez-Garcia et al. Mycotoxin know-how & chemistry of a Effects needs to be that any pressure According a experience in an entity that has long-term from a related difference rot of ...
Arterial visualization by contrast-enhanced moving-table MR angiography: Crossover comparison of 0.1 and 0.2 mmol/kg doses of...Arterial visualization by contrast-enhanced moving-table MR angiography: Crossover comparison of 0.1 and 0.2 mmol/kg doses of...
TY - JOUR. T1 - Arterial visualization by contrast-enhanced moving-table MR angiography. T2 - Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers. AU - Hayashi, Hiromitsu. AU - Yuasa, Yuji. AU - Amano, Yasuo. AU - Tanimoto, Akihiro. AU - Saito, Yoko. AU - Yoshioka, Kunihiro. AU - Kita, Miho. AU - Kumazaki, Tatsuo. AU - Hiramatsu, Kyoichi. PY - 2008/9/1. Y1 - 2008/9/1. N2 - Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 ...
Nutrients | Free Full-Text | Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older...Nutrients | Free Full-Text | Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older...
Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena® ELFA®955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements. Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement. Result: Chronic WGOE supplementation did not affect any measures of cognition. Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic
Carbohydrate balance predicts weight and fat gain in adultsCarbohydrate balance predicts weight and fat gain in adults
Background: The prevention and treatment of obesity is a public health challenge. Objective: We investigated the effects of dietary composition, insulin sensitivity (SI), and energy balance on predicted changes in body composition. Design: In a randomized crossover design study, 39 normal-weight (n = 23), overweight (n = 8), and obese (n = 8) men and women (aged 25-36 y) each followed a 15-d isocaloric high-fat (HF; 50% fat) and high-carbohydrate [HC; 55% carbohydrate (CHO)] diet with a 4-6-wk washout period during the first year. During each treatment, energy balance was measured while the subjects were inactive by using indirect calorimetry on day 15, and S I was measured by using a euglycemic clamp study (40 mU · m-2· min-1) on day 16. Weight and body composition were then measured annually for 4 y. The outcomes for fat mass, percentage body fat, and weight were measured by using a linear 2-stage mixed model. Results: CHO balance (day 15) and SI (day 16) on the HC diet were highly and ...
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This study used a multicenter, randomized, prospective, controlled, open-label, two-period crossover design. Individuals who were routinely treated with intensive, multi-injection insulin therapy using regular human or rapid-acting insulin and insulin glargine were recruited.. The participants entered a 2-week screening period, and if the acceptance criteria were satisfied and written informed consent was given, they were randomly assigned by means of a computer-generated blind random process to one of four cohorts. The first 3-week treatment phase consisted of insulin administration either by SI, a single I-Port device, or two separate I-Port devices (Dual I-Port). Using a two-period crossover design, the participants were reassigned to an alternate treatment regimen for an additional 3 weeks as indicated in Figure 2.. All regimens administered regular human or rapid-acting insulin and insulin glargine, a minimum of two injections daily of either Novolin, Humulin, NovoLog, Humalog, or Apidra ...
Regadenoson: A New Myocardial Stress Agent | JACC: Journal of the American College of CardiologyRegadenoson: A New Myocardial Stress Agent | JACC: Journal of the American College of Cardiology
Adenosine might provoke bronchospasm in certain susceptible patients such as those with asthma or those on maintenance doses of bronchodilators or steroids. The selectivity of regadenoson was therefore of great interest to study for its safety and efficacy in such patients. The final answer is not yet in, and more studies are needed, but there are some preliminary data.. Prior studies have suggested that with prophylactic pre-treatment with a B-2 agonist, adenosine could be given to patients with mild asthma or chronic obstructive lung disease (COPD). It should be noted the majority of patients with COPD but no bronchospasm could be tested with adenosine without any serious problem (39). Further, tachypnea is common after adenosine infusion and is not due to changes in airway resistance or pulmonary capillary wedge pressure but rather to stimulation of carotid body receptors (40,41).. A randomized double-blind, placebo-controlled cross-over trial assessed the safety of regadenoson in 48 patients ...
Cross Over The Church Metal Print by Carmo CorreiaCross Over The Church Metal Print by Carmo Correia
... All metal prints are professionally printed, packaged, and shipped within 3 - 4 business days and delivered ready-to-hang on your wall. Choose from multiple sizes and mounting options.
ANZCTR - RegistrationANZCTR - Registration
The study design is two-period crossover study (repeated measures design) . Participants will complete two trials of 3-minutes pre-oxygenation via non-rebreather mask (NRM)., One trial will have an oxygen flow rate of 15lpm, The other will have the flow-meter valve turned wide open. The end-tidal oxygen (ETO2) will be measured at the end of each trial. The first trial will be followed by a washout period of 2 minutes. Allocation to the first trial (15lpm or fully open valve) will be randomised. ...
Jag to show F-Type design study, performance models at Goodwood - LeftLaneNewsJag to show F-Type design study, performance models at Goodwood - LeftLaneNews
Jaguar has announced it will showcase a new design study based on the F-Type convertible at this weekends Goodwood Festival of Speed. The F-Type show car will be joined at the annual event by Jaguars latest crop of performance vehicles. Jaguar...
Passive Tomography for Spent Fuel Verification: Analysis Framework and Instrument Design Study. Proceedings of 37th ESARDA...Passive Tomography for Spent Fuel Verification: Analysis Framework and Instrument Design Study. Proceedings of 37th ESARDA...
Passive Tomography for Spent Fuel Verification: Analysis Framework and Instrument Design Study. Proceedings of 37th ESARDA Symposium on Safeguards and Nuclear Non-Proliferation, Manchester, UK, 19-21 May 2015. pp 949- ...
Cardiomyopathy or myocarditis from virus - Pagina 4 - BEHANDELING HART EN VAATZIEKENCardiomyopathy or myocarditis from virus - Pagina 4 - BEHANDELING HART EN VAATZIEKEN
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
treatment david 1 - Pagina 2 - BEHANDELING HART EN VAATZIEKENtreatment david 1 - Pagina 2 - BEHANDELING HART EN VAATZIEKEN
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
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Background: Abediterol is a novel, once-daily LABA under development for the treatment of asthma and COPD. The peak bronchodilator effect of single doses of abediterol delivered via Genuair® vs placebo was assessed against salbutamol 400 µg in patients with persistent stable asthma.. Methods: Adult patients were randomized to receive abediterol (0.313, 0.625, 1.25 or 2.5 μg), salbutamol 400 μg and placebo in a 6-period crossover study. Endpoints included change from baseline to peak (primary endpoint) and trough FEV1 and FVC. Safety was also assessed.. Results: A total of 58/62 randomized patients completed the study. Abediterol (all doses) and salbutamol achieved clinically and statistically significant improvements from baseline in peak FEV1 vs placebo (p,0.0001; Table). Peak FEV1 magnitude of effect with abediterol (all doses except 0.313 μg) was similar to salbutamol. Abediterol had a dose-dependent and significantly greater effect on trough FEV1 vs placebo (p,0.0001) and vs salbutamol ...
Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges | BMC Medical Genomics |...Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges | BMC Medical Genomics |...
Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the bodys health. The objective of this study was to select a dietary challenge model for the assessment of inflammatory resilience. Meals are a challenge to metabolic homeostasis and are suggested to affect inflammatory pathways, yet data in literature are limited and inconsistent. The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6,
Most recent papers with the keyword Running, sport | Read by QxMDMost recent papers with the keyword Running, sport | Read by QxMD
PURPOSE: To examine the effects of static and dynamic stretching routines performed as part of a comprehensive warm-up on flexibility and sprint running, jumping and change of direction tests in team sport athletes. METHODS: A randomized, controlled, cross-over study design with experimenter blinding was conducted. On separate days, 20 male team sport athletes completed a comprehensive warm-up routine. After a low-intensity warm-up a 5-s static stretch (5S), 30-s static stretch (30S; 3×10-s stretches), 5-repetition (per muscle group) dynamic stretch (DYN) or no stretch (NS) protocol was completed; stretches were done on 7 lower body and 2 upper body regions ...
Oral administration of 17beta-estradiol over 3 months without progestin co-administration does not improve coronary flow...Oral administration of 17beta-estradiol over 3 months without progestin co-administration does not improve coronary flow...
METHODS: In a double-blind placebo-controlled cross-over design postmenopausal women (60 +/- 5 years, n = 14) were randomized to either start with placebo or E2 (Estrofem, Novo Nordisk, Copenhagen, Denmark) 2 mg/d given orally over 3 months and to switch thereafter for another 3 months of therapy. At baseline, a stress echocardiography was performed to exclude CAD. CFR was determined by coronary sinus CMR flow measurements (with motion-adapted gating and interactive acquisition window control; spatial/temporal resolution of 0.8 x 0.9 mm2/25-30 ms) which were performed at rest and during vasodilation (dipyridamole 0.56 mg/kg over 4 minutes IV) at baseline, and after 3 and 6 months of therapy, respectively ...
Profilseite Christ-Crain M. | Departement Klinische ForschungProfilseite Christ-Crain M. | Departement Klinische Forschung
CARGO study (Copeptin after arginine infusion in the diagnosis of polyuria polydipsia syndrome): observational study evaluating the value of arginine infusion and copeptin measurements in the differential diagnosis of polyuria polydipsia syndrome CARGOx study (Copeptin after arginine infusion compared to copeptin after hypertonic saline infusion for the differential diagnosis of diabetes insipidus) GOLD study (Effects of GLP-1 analogues on fluid intake in patients with primary polydipsia): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in patients with primary polydipsia GATE study (Effects of GLP-1 and analogues on fluid intake in healthy volunteers): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in healthy volunteers SAND study (SGLT-2 inhibitors for treatment of SIADH, a placebo-controlled randomised study) HIT study (Hyponatremia Intervention study) COMEN study (Copeptin in ...
Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic...Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic...
OSU6162 caused a remarkable improvement in mental stamina, as evaluated by a self-assessment scale on mental fatigue. Statistical significance was reached on the primary endpoint (Mental Fatigue Scale). There was a trend towards improvement in the secondary endpoints processing speed and attention. Principal component analysis showed an overall positive treatment effect in 7 of 12 patients. Beneficial responses were seen already during the first few days of active drug treatment. Increasing dosage caused no further improvement. Adverse reactions consisted of short-lasting mild nausea and attenuated appetite. These side effects disappeared upon dose reduction. ...
A double-blind evaluation of skin test suppression produced by two doses of terfenadine<...A double-blind evaluation of skin test suppression produced by two doses of terfenadine<...
TY - JOUR. T1 - A double-blind evaluation of skin test suppression produced by two doses of terfenadine. AU - Bantz, Eric W.. AU - Dolen, William K.. AU - Nelson, Harold S.. PY - 1987/1/1. Y1 - 1987/1/1. N2 - For some patients, terfenadine, in the currently recommended dose of 60 mg twice daily (bid), may be only modestly effective in the treatment of allergic rhinitis. In a double-blind placebo-controlled crossover study of 12 patients, a larger dose (300 mg bid) was evaluated for its suppression of titrated skin tests to histamine and compound 48/80 to determine whether this regimen might result in greater suppression while it maintained the freedom from side effects of the presently recommended dose. In seven patients, skin test suppression by these two doses of terfenadine, each administered for 3 days, was compared to that produced in an earlier study by 3 days of treatment with chlorpheniramine (8 mg three times a day). The 300 mg bid terfenadine regimen produced significantly greater skin ...
Comparative budget impact analysis of treatment sequences in metastatic colorectal cancer (mCRC): from first (1st) line to...Comparative budget impact analysis of treatment sequences in metastatic colorectal cancer (mCRC): from first (1st) line to...
Background In the context of personalized cancer care, patients (pts) should receive the therapy that best meets their needs while optimizing the use of healthcare resources. A budget impact model was developed to compare each of the most commonly used mCRC treatment sequences - from 1st line to 3rd line in a Canadian context.. Methods This Excel based model considers the price of each agent, the number of cycles per treatment course, the relative dose intensity of the regimens to determine the cost of the most commonly used mCRC therapies and calculates the costs per overall sequence from 1st line to 3rd line. It takes into account the percentage of pts who benefit from a R0 resection post 1st line chemotherapy and who forego subsequent treatments. Factors such as different percentage use of 1st line FOLFOX vs FOLFIRI and pts volumes per line of therapy are considered in this model. Users can choose the scenarios they would like to examine. Key variables can be extracted through expert ...
NAFEMS Take Part in the Simulation Driven Design Study engineering analysis and simulation - FEA, Finite Element Analysis, CFD,...NAFEMS Take Part in the Simulation Driven Design Study engineering analysis and simulation - FEA, Finite Element Analysis, CFD,...
Take Part in the Simulation Driven Design Study NAFEMS invites you to participate in the Simulation Driven Design study, being conducted by Lifecycle Insights by completing a short survey. For more than a decade now, engineering organizations have been pushing to use simulation to help make design decisions, not just validate them. But how far have we come? How far do we have left to go? The study aims to answer that exact question. It includes questions on the setup, solve, review and management of s
Abstract 3623: Ramipril Combined with Candesartan Improves Vascular and Metabolic Responses to a Greater Extent Than...Abstract 3623: Ramipril Combined with Candesartan Improves Vascular and Metabolic Responses to a Greater Extent Than...
Background: We investigated vascular and metabolic responses to ramipril and candesartan therapies either alone or in combination in hypertensive patients.. Methods: This was a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms (each 2 months) and two washout periods (each 2 months). Thirty-four patients were given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily during each 2 month treatment period.. Results: Ramipril, combined therapy, or candesartan significantly reduced blood pressure after 2 months administration compared with baseline. All three treatment arms did not significantly change the lipoprotein profile. All three treatment arms significantly improved flow-mediated dilator response to hyperemia. However, combined therapy significantly reduced blood pressure and improved flow-mediated dilation to a greater extent than ramipril or candesartan alone (all P,0.001 by ANOVA). Interestingly, only ...
Postprandial effects of two Chinese liquors on selected cardiovascular by J -S Zheng, Y Yu et al."Postprandial effects of two Chinese liquors on selected cardiovascular" by J -S Zheng, Y Yu et al.
The aim of this study was to investigate postprandial effects of two Chinese liquors on s elected cardiovascular disease risk factors in humans. Sixteen healthy men were randomized into three groups in a three-way crossover study: tea-flavor liquor (TFL), traditional Chinese liquor (TCL) and water control (WC). Every subject consumed 60 mL of either liquor (45% (v/v) ethanol) or water together with a high-fat meal, respectively. Compared with baseline, serum uric acid was significantly increased in TFL group (0.5-hour: P = 0.012; 1-hour: P = 0.001; 2-hour: P = 0.008) and it was significantly decreased in WC group (1-hour: P = 0.001; 2-hour: P = 0.001; 4-hour: P | 0.001), while uric acid was non-significantly increased in the TCL group. High-sensitive C-reactive protein (hs-CRP) was significantly increased in the TCL (P = 0.014) and WC (P = 0.008) groups at postprandial 4 hours compared with baseline. There was no significant difference between groups during the postprandial period for these two
Oxford Brookes UniversityOxford Brookes University
Abstract Background. Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate if inhaled furosemide relieves the air hunger component (uncomfortable urge to breathe) but not the sense of breathing work/effort of dyspnoea. Methods. A randomised, double blind, placebo-controlled crossover trial in 16 healthy volunteers studied in a university research laboratory. Each participant received 3 mist inhalations (either 40 mg furosemide or 4 ml saline) separated by 30-60 min on 2 test days. Each participant was randomised to mist order furosemide-saline-furosemide (n- = 8) or saline-furosemide-saline (n = 8) on both days. One day involved hypercapnic air hunger tests (mean ± SD PCO2 = 50 ± 3.7 mmHg; constrained ventilation = 9 ± 1.5 L/min), the ...
Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers.Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers.
Fifteen out of 18 pink and puffing patients completed a double-blind, placebo-controlled cross-over trial of diazepam and promethazine for breathlessness and reduced exercise tolerance. Dosages were 25 mg and 125 mg daily, respectively, and each co
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To examine the clinical role of BAYm 1099, 15 diettreatednon-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/ day) or placebo after a 4-wk run-in period in a doubleblind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of each treatment period, three test meals (TMs) were administered: 60 g starch (TM1), 25 g sucrose (TM2), and combined 60 g starch and 25 g sucrose (TM3). Twelve subjects completed the study. The peak postprandial blood glucose, lactate, and pyruvate levels (means ± SE) were significantly lower with active drug after all test meals, particularly TM2 (11.3 ±1.0 vs. 14.3 ± 1.4 mM, P ,.001; 1.53 ± 0.20 vs. 2.48 ± 0.17 mM, P , .001; and 105.1 ± 17.6 vs. 147.6 ± 11.1 μM, P , .05, respectively. Peak blood glucose levels were significantly delayed. However, fasting blood glucose, HbA1, fructosamine, and cholesterol did not change during active treatment (10.0 ±1.0 vs. 9.9 ±1.0 mM, ...
Most recent papers with the keyword Hypertension angiotensin renin sodium retention salt | Read by QxMDMost recent papers with the keyword Hypertension angiotensin renin sodium retention salt | Read by QxMD
AIMS/HYPOTHESIS: Glitazones are powerful insulin sensitisers prescribed for the treatment of type 2 diabetes. Their use is, however, associated with fluid retention and an increased risk of congestive heart failure. We previously demonstrated that pioglitazone increases proximal sodium reabsorption in healthy volunteers. This study examines the effects of pioglitazone on renal sodium handling in individuals prone to insulin resistance, i.e. those with diabetes and/or hypertension. METHODS: In this double-blind randomised placebo-controlled four-way crossover study, we examined the effects of pioglitazone (45 mg daily during 6 weeks) or placebo on renal, systemic and hormonal responses to changes in sodium intake in 16 individuals, eight with type 2 diabetes and eight with hypertension ...
Leeds Cosmetic & Plastic Surgery Clinic | Harley Medical GroupLeeds Cosmetic & Plastic Surgery Clinic | Harley Medical Group
We are only 10 minutes walk from Leeds train station. Exit the station and follow the way out to City Square. Cross over two sets of pedestrian crossings and proceed forward across City Square. After City Square turn left onto Infirmary Street, at the end of this road, cross over the pedestrian crossing to the right and then cross over the pedestrian crossing to the immediate left. This will bring you to St Pauls Street. Continue along St Pauls Street for approximately 150 yards and then turn right at Park Square East. This will bring you onto Park Square and the clinic is situated on the far side of the park. The main shopping district is only 10 minutes walk from the clinic. ...
Patente US5190034 - Implantable arrhythmia system with protection against release of unneeded pulses - Google PatentesPatente US5190034 - Implantable arrhythmia system with protection against release of unneeded pulses - Google Patentes
An implantable arrhythmia treatment system includes a sensor which generates an electrical signal corresponding to a physiological characteristic of a patient, the physiological characteristics and thus the electrical signal exhibit a change given the onset of an arrhythmia. The electrical signal is supplied to a fibrillation detector in an implantable housing, which initiates an appropriate treatment sequence upon the detection of the onset of the arrhythmia. Simultaneously with initiating the treatment sequence, the fibrillation detector causes, either by direct connection or by telemetry communication, the generation of an alarm signal which informs the patient that the sequence has been initiated, so that the patient knows that a treatment pulse is about to be released. The implantable unit includes circuitry responsive to a signal externally generated by the patient which prevents the release of the defibrillating pulse. If the patient feels no need for such a pulse, i.e. if the onset of the
Is there and optimal treatment sequence? | OncologyPROIs there and optimal treatment sequence? | OncologyPRO
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
Dose-dependent effect of caffeine supplementation on judo-specific performance and training activity: a randomized placebo...Dose-dependent effect of caffeine supplementation on judo-specific performance and training activity: a randomized placebo...
Caffeine (CAF) supplementation could have a positive impact on physical performance and sport abilities. Nevertheless, the CAF-induced, dose-dependent influence on discipline-specific performance and combat activity in combat sports have not been sufficiently investigated. The aim of this study was to examine the effect of single ingestion of 3, 6, or 9 mg/kg body weight of CAF and placebo (PLA) on judo-specific performance and sparring combat activities. In a randomised double-blind placebo-controlled cross-over design, acute pre-exercise supplementation with CAF (3, 6, or 9 mg/kg body weight) and placebo PLA in 22 male highly-trained judoists was examined. The study protocol involved five separate testing sessions using the Special Judo Fitness Test (SJFT) with heart rate monitoring, three judo sparring combats and evaluation of the rate of perceived exertion (RPE) using the Borg scale. Six and 9 mg/kg CAF improved SJFT performance, while 9 mg/kg increased combat activity. Three mg/kg CAF lacked any
Amgen - Clinical Trials - SynopsisAmgen - Clinical Trials - Synopsis
An Open-label, Randomized, 2-period Crossover Study to Compare the Pharmacokinetic Bioequivalence of a Single 210 mg Dose of Brodalumab Administered to Healthy Subjects by Subcutaneous Injection Using a Prefilled Syringe and an Autoinjector ...
Bakers Yeast Beta Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications of Infection Risk? -...Baker's Yeast Beta Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications of Infection Risk? -...
Strenuous aerobic exercise is known to weaken the immune system, and while many nutritional supplements have been proposed to boost post-exercise immunity, few are known to be effective. The purpose of the present study was to evaluate whether 10 d of supplementation with a defined source of bakers yeast β-glucan (BG, Wellmune WGP®) could minimise post-exercise immunosuppression. Recreationally active men and women (n 60) completed two 10 d trial conditions using a cross-over design with a 7 d washout period: placebo (rice flour) and bakers yeast BG (250 mg/d of β-1,3/1,6-glucans derived from Saccharomyces cerevisiae) before a bout of cycling (49 ± 6 min) in a hot (38 ± 2°C), humid (45 ± 2 % relative humidity) environment. Blood was collected at baseline (before supplement), pre- (PRE), post- (POST) and 2 h (2H) post-exercise. Total and subset monocyte concentration was measured by four-colour flow cytometry. Plasma cytokine levels and lipopolysaccharide (LPS)-stimulated cytokine ...
Fast color grouping and slow color inhibition: evidence for distinct temporal windows for separate processes in preview search....Fast color grouping and slow color inhibition: evidence for distinct temporal windows for separate processes in preview search....
The authors report 4 experiments that examined color grouping and negative carryover effects in preview search via a probe detection task (J. J. Braithwaite, G. W. Humphreys, & J. Hodsoll, 2003). In Experiment 1, there was evidence of a negative color carryover from the preview to new items, using both search and probe detection measures. There was also a negative bias against probes on old items that carried the majority color in the preview. With a short preview duration (150 ms) carryover effects to new items were greatly reduced, but probe detection remained biased against the majority color in the old items. Experiments 2 and 4 showed that the color bias effects on old items could be reduced when these items had to be prioritized relative to being ignored. Experiment 3 tested and rejected the idea that variations in the probability of whether minority or majority colors were probed were crucial. These results show that the time course of color carryover effects can be separated from effects of
The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the...The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the...
A double-blind, three way randomized cross-over clinical trial was conducted in which each participant served as his/her own control. After fasting overnight for at least 10 hours, participants were randomly given 300ml servings of three beverages containing 50g glucose, sucrose and lacritose. Blood samples were collected before and afterwards every 30 minutes for up to 2 hours ...
Effect of time of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or...Effect of time of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or...
We failed to prove our hypothesis that administration of psyllium in the morning would have a greater cholesterol-lowering effect than it would in the evening. Not only was there no observable difference in lipid levels between the crossover periods but the daily ingestion of a greater daily dose than the 10.2 g of psyllium for which the FDA allows health claims to be made [6] had no effect on lipid levels in our study group. No change in any lipid parameter, including total and LDL cholesterol was observed. No difference was found when subgroup analysis was undertaken for the sex of the patients, the time of day they took their psyllium, or whether they were recruited from the gastroenterology clinic or the lipid clinic.. We used a crossover design since this was the most appropriate one for the primary question being addressed; accordingly, our study did not include a control group. However, the nature of the study should not have provided any motivation for study subjects to adopt any new ...
PRIME PubMed | Postprandial platelet aggregation: effects of different meals and glycemic indePRIME PubMed | Postprandial platelet aggregation: effects of different meals and glycemic inde
PubMed journal article Postprandial platelet aggregation: effects of different meals and glycemic inde were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Enhancement of abdominal structures on MRI at 1.5 and 3 T: a retrospective intraindividual crossover comparison<...Enhancement of abdominal structures on MRI at 1.5 and 3 T: a retrospective intraindividual crossover comparison<...
TY - JOUR. T1 - Enhancement of abdominal structures on MRI at 1.5 and 3 T. T2 - European Radiology. AU - AlObaidy,Mamdoh. AU - Ramalho,Miguel. AU - Velloni,Fernanda. AU - Matos,António P.. AU - Herman,Kevin. AU - Semelka,Richard C.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Objective: To quantitatively compare the extent of enhancement of abdominal structures on MRI in an intraindividual fashion at 1.5 and 3 T. Methods: HIPAA-compliant, retrospective, longitudinal, intraindividual, crossover study, with waived informed consent, of consecutive individuals scanned at both 1.5 and 3 T closed-bore magnets using gadobenate dimeglumine during different phases of enhancement at tightly controlled arterial phase timing. Quantitative ROI measurements and qualitative sub-phase arterial phase assignments were independently performed by two radiologists. Qualitative discrepancies were resolved by a senior radiologist. Results: Final population included 60 patients [41 female and 19 male; age, 49.35 ± 18.31 years ...
The Clinical Viewpoint: Definitions, Limitations of RECIST, Practical Considerations of Measurement | Clinical Cancer ResearchThe Clinical Viewpoint: Definitions, Limitations of RECIST, Practical Considerations of Measurement | Clinical Cancer Research
On the other hand, in molecularly selected populations for whom targeted therapies are tested, our ability to detect an OS advantage is severely attenuated by the effects of crossover. In the EURTAC clinical trial, patients with activating mutations in EGFR were treated with targeted therapy with erlotinib (23). This was associated with a 4-month prolongation in PFS, but no benefit in OS (Fig. 3). Seventy-seven percent of patients on the chemotherapy arms of these trials went on to receive EGFR-targeted therapy at the time of progression. Four points are underscored by this clinical trial: (i) crossover is a critical component of clinical trial design both as an ethical necessity and a tool for investigators to maximize accrual; (ii) not every patient in a clinical trial has the opportunity to cross over to the targeted agent (in this trial 23% patients did not cross over), as is the case with patients who have rapid progression of their disease whose performance status might preclude further ...
Mark the Lisles - 12 Weeks to Better Body | Physical Fitness | EatingMark the Lisle's - 12 Weeks to Better Body | Physical Fitness | Eating
Recover Restore Rest / 60-90 sec. Rest ~- STRETCHES Chest Shoulders I / 60-90 sec. Rest I STRETCHES Bend Overs Cross Overs lnner Thigh Forward Lunge Side & Oblique Hurdler Butterfly ITB Thigh Calf 60-90 sec. Rest I WARM-UPS I Jumping Jacks 25 WARM-UPS Running )in Place 30 sec. I I Jumping Jacks 30 Half Jumaincr Jacks 30 1 Half Jumoina Jacks 25 LEGS - 60-90 sec. of water - Crunches (Short) 21 . Rest BURNOUTSLEGS SET I / 60-90 sec.- I Lunoes 29 LEGS 1 Reoular 2-4-6-8-6-4-2 1 Hand to Toe I PULL-UPS Reverse 2-4-6-4-2 Behind the Neck 1-3-5-3-1 SET 2 -----I T~Fats391I Fire Hvdrants 23 (Each Side) I Mountain Climber 17 i The Wall 1. 13x) / Bend Overs STRETCHES 1Cross Overs 7lnner Thiah I Forward Lunoe 1 Side & Obliaue 1 Hurdler i Mountam Climbers 15 I I SPRINTS 1 Intervals (Optional) 6 Laps = 2400 yds. C -* SUPPLEMENTS SUPPLEMENTS SUPPLEMENTS SUPPLEMENTS [Beforel T m m Energy Plus1 Electrolyte Recover a I I Electrolyte Energy Plus a -r7GG-l Recover m El Restore El Restore 1 11 1 ...
Helpfulwaves : Epinephrine as Healing Pink Noise AudioHelpfulwaves : Epinephrine as Healing Pink Noise Audio
I often use the word "healing", though helpful or mitigating may be more appropriate. Many people find some relief or benefit listening to the audio tones, in Pink noise format, with their health conditions. I match herbs, medications, vitamins etc., that have some positive cross over physiological effects on the body. Not all of the chemical or molecular effects cross over with the designer field, but they do play a role within the body. The best way is to try out some designer frequencies and see if they are helpful or not. ...
Helpfulwaves : Morphine as Healing Pink Noise AudioHelpfulwaves : Morphine as Healing Pink Noise Audio
I often use the word "healing", though helpful or mitigating may be more appropriate. Many people find some relief or benefit listening to the audio tones, in Pink noise format, with their health conditions. I match herbs, medications, vitamins etc., that have some positive cross over physiological effects on the body. Not all of the chemical or molecular effects cross over with the designer field, but they do play a role within the body. The best way is to try out some designer frequencies and see if they are helpful or not. ...
Tolero Pharmaceutical, Inc.Tolero Pharmaceutical, Inc.
Patients randomized to CM who exhibit progressive disease or no response after a single cycle of CM, or who have a best response of PR after 2 cycles of CM, may cross over to receive ACM. Patients who cross over to ACM may receive up to a combined total (CM + ACM) of 4 cycles. †High-risk AML is characterized by treatment-related AML, secondary AML defined as AML from preexisting myelodysplastic syndromes or myeloproliferative neoplasms, or adverse-risk cytogenetics according to 2017 European LeukemiaNet Guidelines. MCL-1=myeloid cell leukemia 1; IV=intravenous; CR=complete remission; PR=partial remission. ...
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Cross-Over StudiesDouble-Blind MethodTreatment OutcomeAir Pollutants, OccupationalTime FactorsHolidaysReinforcement ScheduleCircadian RhythmByssinosisDrug Administration ScheduleCultural CompetencyCommunication BarriersJournalismCross-Cultural ComparisonPosters as TopicJournalism, DentalNewcastle disease virusTranslationsCultural CharacteristicsLanguageTranslatingCultural DiversityForeign Professional PersonnelAlaskaEducation, GraduateEthnobotanyDissertations, Academic as TopicSculptureArtHumanitiesFaculty, MedicalCrosses, GeneticMice, Inbred StrainsQuantitative Trait LociFertility AgentsNational Human Genome Research Institute (U.S.)GenomeModels, BiologicalColonialismFellowships and ScholarshipsSlovakiaMedical TourismMultilingualismCzech RepublicDementiaPubMedPeriodicals as TopicBooksPublishingMEDLINESaintsStudentsSister Mary Joseph's NoduleFacultyStudents, Medical
MethodsPatientsSubjectsPopulationLongitudinal Study2017Cohort2018Centre for Dev2016Prevalence studyFindingsInterventionalPostgraduateAbstractIndiaAttitudesEpidemiologicAdultsMulti-centreInvestigatorsOBJECTIVEEmpiricalPsychologyDesignDescribeAnthropologyBiasAdultMethodologicalMajorsCentersChristLaboratoryMainPerspectivesContentNeutronIndigenousGeneticCase studiesCloselyJournalPublishBibleExploresOrganizationExamineInfantsAdolescentsEfficacyExaminesMortalityHoly CrossElongationOccupationalCriticalTheoreticalExaminationMaster's
Methods1
Patients2
  • Patients taking statin medication were asked to stop that medication for four weeks before entering the study. (nih.gov)
  • The aim of this study is to examine the efficacy of anamorelin in improving appendicular skeletal muscle mass (ASM) and patient-reported outcomes in patients with MM with cachexia. (edu.au)
Subjects1
Population1
  • The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in South Asians with dyslipidemia and endothelial dysfunction, a population at high risk for premature coronary artery disease. (nih.gov)
Longitudinal Study9
20172
  • On 20-22 September 2017, the Lower Austria region hosted a study visit entitled "Cross-border health care" in the city of Sankt Pölten. (who.int)
  • CAMBRIDGE, Mass. - Aug. 10, 2017 - eGenesis, a biotechnology company focused on transforming xenotransplantation into a lifesaving medical procedure, announced the publication of a study in the journal Science by eGenesis scientists and their collaborators demonstrating the inactivation of PERV to prevent cross-species viral transmission and a breakthrough in producing the first PERV-free pigs, an important milestone for xenotransplantation. (eurekalert.org)
Cohort6
  • Unlike in a cohort study, however, matching does not on its own eliminate confounding. (bmj.com)
  • The study is based on the Danish National Birth Cohort, established in 1. (bioportfolio.com)
  • Alzheimer's Disease Sequencing Project discovery and replication criteria for cases and controls: Data from a community-based prospective cohort study with autopsy follow-up. (cambridge.org)
  • The baseline cross section of the Multi-Ethnic Study of Atherosclerosis recruited a population-based cohort of 6781 persons, aged 45-84 years, from 6 communities in the United States. (diabetesjournals.org)
  • We therefore analyzed longitudinal data from the Atherosclerosis Risk in Communities (ARIC) Study, a biracial, community-based cohort of adults aged 45-64, to test the hypothesis that diabetes is associated with reduced lung function independently of known risk factors. (diabetesjournals.org)
  • The basic objective of the HELENA cross-sectional multi-centre study was to obtain reliable and comparable data from a selected cohort of European adolescents (boys and girls aged 13-16 years) on a broad battery of relevant nutrition and health-related parameters: dietary intake, food choices and preferences, anthropometry, serum indicators of lipid metabolism and glucose metabolism, vitamin and mineral status, immunological markers, physical activity, fitness and genetic markers. (nature.com)
20181
  • Stijepic, Damir, A Cross-Country Study of Workers' Skills and Unemployment Flows (August 31, 2018). (ssrn.com)
Centre for Dev1
  • In their 2015 paper "Changing Cities and Changing Lives: Development Induced Displacement in Kochi, Kerala", researchers with the Centre for Development Studies and Union Christian College examine the lives of those uprooted by development. (idrc.ca)
20162
  • Ph.D. in Indigenous Studies, with an emphasis in Indigenous Leadership from the University of Alaska Fairbanks, of May 2016. (uaf.edu)
  • 3rd wave: February - May 2016) study was performed simultaneously in eleven European countries. (europa.eu)
Prevalence study1
  • A one-day prevalence study was conducted using the methodology specified by the European Pressure Ulcer Advisory Panel, together with the established methods used by the Collaborative Alliance for Nursing Outcomes. (nih.gov)
Findings7
  • 1980. Toward Explaining Human Culture: A Critical Review of the Findings of Worldwide Cross-Cultural Research. (wikipedia.org)
  • To give an extreme example, a case-control study of bladder cancer and smoking could give quite erroneous findings if controls were taken from the chest clinic. (bmj.com)
  • Findings from this study will also appear in a Museum Learning volume (co-authored with Jill Hohenstein). (ucl.ac.uk)
  • Cross-sectional studies must be done on representative samples of the population if generalizations from the findings are to have any validity. (encyclopedia.com)
  • Researchers in a wide range of relevant fields, from political economy to social policy to the study of civic life, will benefit from close scrutiny of the empirical findings of this project. (routledge.com)
  • In this study, over half of clinical trials initiated for rare diseases were either discontinued or not published 4 years after completion, resulting in large numbers of patients with rare diseases exposed to interventions that did not lead to informative findings. (plos.org)
  • Findings of the cross-scale model intercomparison will be published and serve as a basis for fund raising. (pik-potsdam.de)
Interventional1
  • A potential limitation of our study is that certain interventional trials for rare diseases may not have been registered in ClinicalTrials.gov, in particular Phase 0 and Phase I trials, which are not required to be registered. (plos.org)
Postgraduate1
  • The MA in Latin American History sees the school, and HiPLA in particular, make a critical advance in postgraduate studies through its historical provision. (bristol.ac.uk)
Abstract1
  • The current study tests whether this discrepancy between abstract representations and acoustic realizations influences how native speakers of Japanese perceive geminate consonants. (frontiersin.org)
India2
  • In a multicentre study, the 10/66 Dementia Research Group interviewed 2885 people aged 60 years and older in 25 centres, most in Universities, in India, China and southeast Asia, Latin America and the Caribbean, and Africa. (nih.gov)
  • This study indicates that parental characteristics, such as age, educational attainment and employment substantially determine child health in India, suggesting that an intervention by targeting the households where children are vulnerable is important to improve child health in the country. (nature.com)
Attitudes4
  • Within this study we wanted to find out whether experiencing moral doubt is related to the normative attitudes of health care professionals towards coercion. (biomedcentral.com)
  • The Intergenerational Transmission of Risk and Trust Attitudes ," Review of Economic Studies , Oxford University Press, vol. 79(2), pages 645-677. (repec.org)
  • The Intergenerational Transmission of Risk and Trust Attitudes ," IZA Discussion Papers 2380, Institute for the Study of Labor (IZA). (repec.org)
  • Cross-sectional studies, also known as surveys, are a useful way to gather information on important health-related aspects of people's knowledge, attitudes, and practices (such studies are known as "KAP" surveys). (encyclopedia.com)
Epidemiologic1
Adults5
  • This study aims to describe the distribution of serum cholesterol in a community living population of older adults in Ireland and to examine the awareness, treatment and control of hypercholesterolaemia according to CVD risk status. (springer.com)
  • The aim of this study is to document the distribution of serum cholesterol in a community living population of older adults aged 50-79 years in Ireland and apply clinical guideline targets [ 9 ] to examine the awareness, treatment and control of hypercholesterolaemia in a subgroup aged 50-64 years according to their absolute risk of CVD. (springer.com)
  • Results of studies in adults have suggested that lipid testing might be reliably performed without fasting. (aappublications.org)
  • Half of the adults studied do not meet the EFSA fluid intake recommendations. (isciii.es)
  • Cross-sectional studies have consistently shown that adults with diabetes have lower vital capacity than their nondiabetic counterparts ( 1 - 5 , 7 ), but such studies cannot establish the temporal sequence of events. (diabetesjournals.org)
Multi-centre2
Investigators2
OBJECTIVE4
  • The main objective of the study visit was to facilitate an in-depth exchange on the topic of the cross-border health care, introduce current related programmes and large-scale innovative projects in Lower Austria, and provide an opportunity for sharing ideas and practical approaches in this field within RHN. (who.int)
  • Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases. (plos.org)
  • The evaluation of the fluid consumption pattern of a population has been the main objective of only a very few studies. (isciii.es)
  • OBJECTIVE -The aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally. (diabetesjournals.org)
Empirical2
  • Both studies in ethics and empirical studies come with different and sometimes contradictive arguments. (biomedcentral.com)
  • It explores the nature of the interaction between community involvement and political leadership in modern local governance by drawing on empirical data gathered from case-studies concerning cities in England, Germany, Greece, Italy, the Netherlands, New Zealand, Norway, Poland, and Sweden. (routledge.com)
Psychology8
  • Cross-cultural studies, sometimes called holocultural studies or comparative studies, is a specialization in anthropology and sister sciences (sociology, psychology, economics, political science) that uses field data from many societies to examine the scope of human behavior and test hypotheses about human behavior and culture. (wikipedia.org)
  • Cross-cultural studies are applied widely in the social sciences, particularly in cultural anthropology and psychology. (wikipedia.org)
  • Comparative cultural studies Cross-cultural Cross-cultural capital Cross-cultural communication Cross-cultural psychiatry Cross-cultural psychology Cultural bias Cultural relativism Ethnocentrism Human Relations Area Files Kluckhohn and Strodtbeck's values orientation theory Standard cross-cultural sample Avner Ben-Zaken, "From "Incommensurability of Cultures" to Mutually Embraced Zones" in Cross-Cultural Scientific Exchanges In the Eastern Mediterranean 1560-1660 (Johns Hopkins University Press, 2010)], pp. 163-167. (wikipedia.org)
  • Cross-Cultural Research Journal of Cross-Cultural Psychology World Cultures Structure and Dynamics eJournal of the Anthropological and Related Sciences Transtext(e)sTranscultures: Trilingual Journal of Global Cultural Studies Social Evolution & History Society for Cross-Cultural Research Institut d'études Transtextuelles et Transculturelles (IETT), Institute for Transtextual and Transcultural Studies, Lyons, France. (wikipedia.org)
  • Professor K. Ramakrishna Rao is a philosopher and psychologist with expertise in Indian psychology, consciousness studies and parapsychological research. (barnesandnoble.com)
  • The ethics committee at the School of Psychology, Queen's University Belfast, approved the study. (springer.com)
  • This study guide aims to make European trainees in forensic psychiatry and psychology and young forensic psychiatrists and psychologists aware of the differences and commonalities in forensic psychiatry and psychology in different countries within Europe and to enable them to learn from the approaches adopted in each country. (springer.com)
  • Beginning with the fundamentals of human interactions, this edited volume allows scholars across a variety of disciplines (such as criminology, sociology, communication studies, social psychology, anthropology, and economics) to become familiar with and apply the core principles and the requisite terminology of human communication within a criminological context. (peterlang.com)
Design11
Describe3
  • Simply put, it is a study that aims to describe the relationship between diseases (or other health-related states) and other factors of interest as they exist in a specified population at a particular time, without regard for what may have preceded or precipitated the health status found at the time of the study. (encyclopedia.com)
  • This chapter will describe the development of a study abroad program designed to assist preservice teachers in developing and utilizing these skills and dispositions in a global setting. (igi-global.com)
  • This chapter will describe how three professors integrated cross-curricular projects grounded in children's and young adult literature, historical literacy, and understanding diverse populations. (igi-global.com)
Anthropology2
Bias3
  • In that way, if one of the control diseases happens to be related to a risk factor under study, the resultant bias is not too large. (bmj.com)
  • Bias in cross-cultural neuropsychological testing: problems and possible solutions. (cambridge.org)
  • The great advantage of the HELENA-CSS is the strict standardization of the fieldwork and the blood analyses, which precludes to a great extent the kind of immeasurable confounding bias that often interferes when comparing results from isolated studies. (nature.com)
Adult3
  • Despite a substantial reduction in population mean TC from a high of 6.0 mmol/L in the 1980s to 5.1 mmol/L, this study reports a failure to control hypercholesterolaemia to recommended risk-stratified targets in the Irish adult population. (springer.com)
  • This study compared AAB for alcohol cues across age groups (early adolescent, late adolescent, and young adult) and drinking groups (heavy drinkers, light drinkers, and non-drinkers) to provide a cross-sectional examination of differences in AAB and their relationship to alcohol use and age. (springer.com)
  • Results of studies in adult patients are raising questions of whether fasting is needed before lipid screening. (aappublications.org)
Methodological2
  • This paper contributes to cross-cultural research by identifying the theoretical and methodological strengths and weaknesses of selected previous research related to accountants' values and judgments. (repec.org)
  • The study combines analytical and methodological approaches from motivation, multimodality and embodied interaction to explore their effectiveness for gaining insight into the relationship between motivation to visit an exhibition and particular exhibits within it, the elicitation of embodied forms of interaction - in particular social and emotional experiences - with digitally mediated exhibits, and their role in fostering meaning making and learning in a family context. (ucl.ac.uk)
Majors3
  • Many economics majors participate in the College's Study Abroad Program. (holycross.edu)
  • Economics majors are strongly encouraged to complete the calculus requirement during their first year at Holy Cross. (holycross.edu)
  • Economics majors studying abroad may take one economics course for credit as a lower level elective provided that an appropriate course can be found and is pre-approved by the department. (holycross.edu)
Centers1
Christ5
  • Make this declaration: "Heavenly Father, I accept without reservation the supernatural atonement of Jesus Christ on the cross. (ligonier.org)
  • It was my determination to concentrate entirely on Jesus Christ himself and the fact of his death upon the cross. (acts17-11.com)
  • Gal 6:12 (NAS) Those who desire to make a good showing in the flesh try to compel you to be circumcised, simply that they may not be persecuted for the cross of Christ. (acts17-11.com)
  • We know the suffering and humiliation that Christ suffered on the cross and the gruesome death that he endured for our sins. (spreadinglight.com)
  • If we refuse to take up our cross and submit to suffering and rejection at the hands of men, we forfeit our fellowship with Christ and have ceased to follow him. (spreadinglight.com)
Laboratory4
  • A Nation-Wide Laboratory: Examining Trust and Trustworthiness by Integrating Behavioral Experiments into Representative Surveys ," IZA Discussion Papers 715, Institute for the Study of Labor (IZA). (repec.org)
  • Existing developed AI vaccines, H5, H7 or H9 may be used in vaccination programmes customised to the ever evolving situation worldwide, as long as laboratory cross-protection studies are performed to help demonstrate efficacy. (thepoultrysite.com)
  • The mouse has been an important model for studying Aspergillus infection, but classical laboratory strains of mice used in these studies arose from a small set of founders and lack most of the genetic variation present in wild mice, limiting researchers' ability to identify additional genetic loci relevant to disease. (redorbit.com)
  • Once again, this format of cross-border study visits - a combination of seminars, workshops and visits to health facilities - proved to be an excellent laboratory for public health innovation. (who.int)
Main3
  • Superabsorbant Hydrogels: A Study of the Most Effective Application of Cross-linked Polyacrylamide Polymers main content. (amnh.org)
  • This ensured achievement of the main purpose of the study visit, namely, to enable the participants to facilitate the establishment of new contacts and provide opportunities for future cross-border collaboration. (who.int)
  • Our main outcome measures were the frequency of trial noncompletion and, among completed studies, frequency of trial nonpublication at 2 and 4 years following trial completion. (plos.org)
Perspectives3
Content3
  • Before, during, and after the study abroad commitment, students experience and live both their curricular content as well as their culturally diverse experiences. (igi-global.com)
  • The study abroad experience required courses from both teacher education and general education content. (igi-global.com)
  • Study abroad experiences are inherently two-fold: Before, during, and after their involvement, students immerse themselves in both the curricular content and in a diverse culture. (igi-global.com)
Neutron3
  • The AMPX system was used to generate a P$sub 3$ 218 neutron group master cross-section library from ENDF/B-IV data for the fuel, structural, and neutron- absorbing materials tabulated. (unt.edu)
  • The libraries, designated ANSL-V (Advanced Neutron Source Cross Section Libraries based on ENDF/B-V) are data based in AMPX master format. (oecd-nea.org)
  • In support of local projects, ORNL extended the Sn neutron cross sections down to 10 -5 eV and changed the mat number to 8850, while the gamma-ray identifier was unchanged from 7850. (oecd-nea.org)
Indigenous4
Genetic8
  • The Collaborative Cross (CC) represents a large collection of new inbred mouse strains created by the mouse genetics community aimed at revolutionizing the study of complex genetic traits and diseases. (redorbit.com)
  • In this work, Aylor and colleagues performed an experiment called the "the pre-CC study," the first genetic data and analysis from the emerging strains of the CC. Their investigation revealed that the genomes of CC strains are genetically diverse and contain balanced contributions from each founding strain. (redorbit.com)
  • Genetic analysis of complex traits in the emerging collaborative cross. (redorbit.com)
  • The development of the Collaborative Cross presents a unique opportunity to investigate how the breeding of inbred strains affects genetic structure and the diversity of phenotypes. (redorbit.com)
  • Genetic analysis in the Collaborative Cross breeding population. (redorbit.com)
  • In this study, Durrant and colleagues utilized inbred mouse strains from the Collaborative Cross, taking advantage of the genetic contribution of wild-derived strains, to identify novel loci that confer susceptibility to infection with the fungus Aspergillus. (redorbit.com)
  • We conducted a cross-sectional analysis of randomized clinical trials studying rare diseases as defined by the Genetic and Rare Disease Information Center database that were registered in ClinicalTrials.gov between January 1, 2010, and December 31, 2012, and completed or discontinued by December 31, 2014. (plos.org)
  • Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease. (cambridge.org)
Case studies3
  • The first is comparison of case studies, the second is controlled comparison among variants of a common derivation,[clarification needed] and the third is comparison within a sample of cases. (wikipedia.org)
  • You are encouraged to apply your research interests to real world case studies, particularly of international organisations or workplaces with which you have a connection. (ncl.ac.uk)
  • New urban leaders and community involvement: The Italian case studies 5. (routledge.com)
Closely1
  • Basic demonstrable academic knowledge in the field of Media Studies or a closely related discipline. (uva.nl)
Journal3
  • Together with Douglas R. White, he developed the widely used Standard Cross-Cultural Sample, currently maintained by the open access electronic journal World Cultures. (wikipedia.org)
  • Published in the British Journal of Nutrition, ​the study found that intakes were higher among males compared to females, mainly due to larger quantities of food consumed daily. (nutraingredients.com)
  • The paper discussed was the draft introductory article for a special issue of the Journal of Common Market Studies. (uio.no)
Publish1
  • For example, the Massachusetts Blue Cross/Blue Shield apparently thinks that you can't publish a study criticizing its doctors without permission thanks to trademark law. (techdirt.com)
Bible4
  • The Life Application Study Bible is today's #1-selling study Bible, containing notes that not only explain difficult passages and give information on Bible life and times, but also go a step further to show how God's Word speaks to every situation and circumstance of your life! (christianbook.com)
  • I'm the author/artist and I want to review NLT Life Application Study Bible, Personal Size TuTone Leatherlike Black/Celtic Cross . (christianbook.com)
  • The ESV Study Bible, Personal Size compresses nearly all the features of the award-winning ESV Study Bible into a smaller size for easier carrying. (parable.com)
  • Suited to high school and college students, the ESV Student Study Bible is also a versatile resource for anyone engaged in serious study of God's Word. (bookwire.com)
Explores3
  • This cross-cultural examination first explores the varieties of conscious experience and reflects on the attempts to understand and explain consciousness in the Western scholarly and scientific tradition. (barnesandnoble.com)
  • The Master's in Television and Cross-Media Culture explores contemporary media culture from a critical perspective. (uva.nl)
  • iv) The present author finds the logic of the reply faulty.This volume explores verbal and pronominal agreement with imposters from a cross-linguistic perspective. (indigo.ca)
Organization2
Examine1
  • The study, which is continuing, was apparently the first to examine the injury impact of such a wide range of high school sports. (nytimes.com)
Infants2
Adolescents1
  • Up to now, there has been no study at the European level that has investigated the nutritional status and lifestyle of adolescents using a central standard methodology across a consortium of several participating countries. (nature.com)
Efficacy2
Examines2
  • Unlike comparative studies, which examines similar characteristics of a few societies, cross-cultural studies uses a sufficiently large sample so that statistical analysis can be made to show relationships or lack of relationships between the traits in question. (wikipedia.org)
  • This study examines the associations between different types of infant feeding and BMI and overweight in childhood. (bioportfolio.com)
Mortality1
  • A cross-protection study using a 2010 field isolate as a challenge virus helped understand the mechanisms involved by designing a cold stress protocol needed for induction of mortality and clinical signs (Delvecchio et Al, 2015). (thepoultrysite.com)
Holy Cross2
  • Seven of the nine required courses for the economics major must be taken within the Department of Economics and Accounting at Holy Cross. (holycross.edu)
  • Both intermediate theory courses (Econ 255 and Econ 256) must be taken within the Department of Economics and Accounting at Holy Cross. (holycross.edu)
Elongation1
  • On the other hand, the change in the potential energies owing to the uniaxial elongation indicated that cross-links suppressed local segmental motions in the cross-linked structure, probably at the region around the linear and terminal phenols , which resulted in an increase in the degree of cross-linking accompanied by a decrease in Poisson's ratio and an increase in Young's modulus. (rsc.org)
Occupational1
  • Such a study would throw some light on the relationship of both occupational exposures and smoking behavior to respiratory symptoms and respiratory function. (encyclopedia.com)
Critical2
  • The CC is a tool to integrate studies of gene function and gene networks, allowing the prediction and testing of biological models based on the whole organism, critical to the development of personalized therapies for humans. (redorbit.com)
  • The Critical Illness policy can only be purchased in conjunction with a health insurance policy underwritten by Southern Cross Medical Care Society. (southerncross.co.nz)
Theoretical2
  • The Cross-Cultural Communication and Media Studies MA provides theoretical, research and practical training in areas of international and intercultural communication and the media. (ncl.ac.uk)
  • Find out how theoretical calculations are used to determine, elucidate and propose mechanisms for Pd-catalyzed C-C cross-coupling reactions in Max Garcia Melchor's outstanding thesis. (springer.com)
Examination1
Master's3
  • The one-year Master's programme Television and Cross-Media Culture provides you with the skills, knowledge and tools to understand and evaluate the ongoing transformation of media culture. (uva.nl)
  • The Television and Cross-Media Culture specialisation within the Media Studies Research Master's Programme focuses on the on-going transformation of media culture, and its impact on culture, politics and everyday life. (uva.nl)
  • After successful completion of this programme, you will receive a legally accredited Master's degree in Media Studies and the title Master of Arts (MA). (uva.nl)
Two studies of the cross section and longitudinal section of a Colour Globe, 1809 | PBS LearningMedia
Two studies of the cross section and longitudinal section of a Colour Globe, 1809 | PBS LearningMedia (pbslearningmedia.org)
Molecular and serological surveys of canine distemper virus: a meta-analysis of cross-sectional studies
Molecular and serological surveys of canine distemper virus: a meta-analysis of cross-sectional studies (protocols.io)
Reminiscence bump - Wikipedia
Reminiscence bump - Wikipedia (en.wikipedia.org)
The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular...
The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular... (link.springer.com)
Consciousness Studies: Cross-Cultural Perspectives by K. Ramakrishna Rao, Paperback | Barnes & Noble®
Consciousness Studies: Cross-Cultural Perspectives by K. Ramakrishna Rao, Paperback | Barnes & Noble® (barnesandnoble.com)
Plus it
Plus it (care.diabetesjournals.org)
IJMS | Free Full-Text | DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A...
IJMS | Free Full-Text | DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A... (mdpi.com)
Project MUSE - Eco-Critical Literature
Project MUSE - Eco-Critical Literature (muse.jhu.edu)
Ethnic studies - University of Hawaiʻi System News
Ethnic studies - University of Hawaiʻi System News (hawaii.edu)
R021 Kilborn, K., & Ito, T. (1989). Sentence processing strategies in… - English
R021 Kilborn, K., & Ito, T. (1989). Sentence processing strategies in… - English (slideshare.net)
Half-hour studies at the cross by J. H. Garrison | LibraryThing
Half-hour studies at the cross by J. H. Garrison | LibraryThing (librarything.com)
CiteSeerX - Citation Query Cross-Organizational Data Quality and Semantic Integrity: Learning and Reasoning about Data...
CiteSeerX - Citation Query Cross-Organizational Data Quality and Semantic Integrity: Learning and Reasoning about Data... (citeseer.ist.psu.edu)
Staff - Andrey Korotayev - HSE University
Staff - Andrey Korotayev - HSE University (hse.ru)
Professional Military Education
Professional Military Education (peterlang.com)
A statistical framework for cross-tissue transcriptome-wide association analysis | Nature Genetics
A statistical framework for cross-tissue transcriptome-wide association analysis | Nature Genetics (nature.com)
Differential IFN-γ Stimulation of HLA-A Gene Expression through CRM-1-Dependent Nuclear RNA Export | The Journal of Immunology
Differential IFN-γ Stimulation of HLA-A Gene Expression through CRM-1-Dependent Nuclear RNA Export | The Journal of Immunology (jimmunol.org)
Languages of political economy : cross-disciplinary studies on economic translations by Elena Carpi | LibraryThing
Languages of political economy : cross-disciplinary studies on economic translations by Elena Carpi | LibraryThing (librarything.com)
Labor Unions Seek Cross-Border Links - WSJ
Labor Unions Seek Cross-Border Links - WSJ (wsj.com)
Most Popular Articles : PAIN
Most Popular Articles : PAIN (journals.lww.com)
Postcolonial Poland - an (Im)possible Project : From Modern Theory to a Poetics of Experience
Postcolonial Poland - an (Im)possible Project : From Modern Theory to a Poetics of Experience (peterlang.com)
Photography | Hatje Cantz
Photography | Hatje Cantz (hatjecantz.de)
Cross-Cultural Indigenous Knowledge Exchange | University of Northern British Columbia
Cross-Cultural Indigenous Knowledge Exchange | University of Northern British Columbia (unbc.ca)
Barnet Local Studies and Archives Bed and Breakfast, Cheap Hotel and Guest House Accommodation
Barnet Local Studies and Archives Bed and Breakfast, Cheap Hotel and Guest House Accommodation (bedandbreakfasts.co.uk)
The Relationship Between Sleep Disturbance, Suicidal Ideation, Suicide Attempts, and Suicide Among Adults: A Systematic Review
The Relationship Between Sleep Disturbance, Suicidal Ideation, Suicide Attempts, and Suicide Among Adults: A Systematic Review (healio.com)
Recovering Pompeii | www.scienceinschool.org
Recovering Pompeii | www.scienceinschool.org (scienceinschool.org)
Sources of Conflict in Cross-Border Services Rules for VAT by Rebecca Millar :: SSRN
Sources of Conflict in Cross-Border Services Rules for VAT by Rebecca Millar :: SSRN (papers.ssrn.com)
Cross-Linguistic Studies of Imposters and Pronominal Agreement, Book by Chris Collins (Paperback) | chapters.indigo.ca
Cross-Linguistic Studies of Imposters and Pronominal Agreement, Book by Chris Collins (Paperback) | chapters.indigo.ca (chapters.indigo.ca)
Accepting the Atonement of the Cross | Reformed Bible Studies & Devotionals at Ligonier.org
Accepting the Atonement of the Cross | Reformed Bible Studies & Devotionals at Ligonier.org (ligonier.org)
Publications | Page 2 | Australian Institute of Family Studies
Publications | Page 2 | Australian Institute of Family Studies (aifs.gov.au)
1981 | Banner of Truth USA
1981 | Banner of Truth USA (banneroftruth.org)
Interdisciplinary Studies in Human Behavior (M.A.) | Hood College
Interdisciplinary Studies in Human Behavior (M.A.) | Hood College (hood.edu)
Publications | Page 3 | Australian Institute of Family Studies
Publications | Page 3 | Australian Institute of Family Studies (aifs.gov.au)
Family law | Australian Institute of Family Studies
Family law | Australian Institute of Family Studies (aifs.gov.au)
Past Projects | Page 2 | Australian Institute of Family Studies
Past Projects | Page 2 | Australian Institute of Family Studies (aifs.gov.au)
College of the Holy Cross - The Princeton Review College Rankings & Reviews
College of the Holy Cross - The Princeton Review College Rankings & Reviews (princetonreview.com)