The circulation in a portion of the body of one individual of blood supplied from another individual.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
Substances elaborated by bacteria that have antigenic activity.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A developmental malformation of the heart characterized by a twisted but not defective atrioventicular connection. The abnormal rotation of the ventricular mass around its long axis results in the crossing of the inflow streams of the two ventricles. Other features include hypoplasia of the TRICUSPID VALVE and RIGHT VENTRICLE.
A congenital abnormality in which organs in the THORAX and the ABDOMEN are opposite to their normal positions (situs solitus) due to lateral transposition. Normally the STOMACH and SPLEEN are on the left, LIVER on the right, the three-lobed right lung is on the right, and the two-lobed left lung on the left. Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A congenital defect in which the heart is located on the right side of the THORAX instead of on the left side (levocardia, the normal position). When dextrocardia is accompanied with inverted HEART ATRIA, a right-sided STOMACH, and a left-sided LIVER, the combination is called dextrocardia with SITUS INVERSUS. Dextrocardia may adversely affect other thoracic organs.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.
Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Contamination of the air by tobacco smoke.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Prohibition against tobacco smoking in specific areas to control TOBACCO SMOKE POLLUTION.
An area of recreation or hygiene for use by the public.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Act of listening for sounds within the heart.
Act of listening for sounds within the body.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Emulsions of fats or lipids used primarily in parenteral feeding.
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The transference of a kidney from one human or animal to another.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Effects of prostaglandin E(1) on the efficacy of xenogeneic extracorporeal pig liver perfusion in a canine model of acute liver failure. (1/42)

Xenogeneic extracorporeal liver perfusion (ECLP) has the potential to become an important tool in the management of patients with severe liver failure. We previously showed that xenogeneic pig liver perfusion may be prolonged for up to 9 hours by the administration of prostaglandin E(1) (PGE(1)). In this study, we used a canine model of acute liver failure to evaluate the effects of PGE(1) on the efficacy of ECLP as a liver-assist device. Liver failure was surgically induced in 12 beagle dogs, with a control group (group 1, n = 4) not connected to the ECLP circuit. Direct cross-circulation between the dogs and the ECLP circuit using a pig liver was performed without (group 2, n = 4) or with (group 3, n = 4) continuous administration of PGE(1) through the portal vein of the pig liver. The duration of cross-circulation in group 3 (9.4 +/- 1.2 hours) was significantly longer than in group 2 (4.3 +/- 1.0 hours). In addition, elevation of blood ammonia, total bile acid, and hyaluronic acid levels was less marked in group 3 compared with the other 2 groups. The ratio of branched-chain amino acids to aromatic amino acids was also improved in group 3. The mean survival time in group 3 (26.6 +/- 0.4 hours) was significantly longer than in group 1 (15.5 +/- 1.3 hours) or group 2 (17.1 +/- 2.9 hours). Continuous administration of PGE(1) to xenogeneic ECLP resulted in a significant improvement in both liver function and survival time of dogs with surgically induced liver failure.  (+info)

Influence of extracorporeal porcine liver perfusion on nonhuman primates: minimizing hemolysis improves subsequent survival. (2/42)

The aim of this study is to detect and analyze risk factors of direct cross-circulation between porcine liver and nonhuman primates before a clinical application of extracorporeal liver perfusion (ECLP) as a liver-assist method. Porcine livers were perfused with baboon blood in an ECLP system. Six healthy baboons were directly connected to the ECLP system with continuous prostaglandin E(1) administration. Cross-circulation was terminated in the following circumstances: (1) hepatic arterial or portal perfusion pressures elevated to 200 or 60 mm Hg, respectively; (2) massive exudative bleeding from the graft surface; or (3) bile output decreased to less than 5 microL/h/g of liver weight. In case 1, cross-circulation was continued for 10 hours. Severe macroscopic hemolysis occurred, and serum hemoglobin (s-Hb) concentration reached a peak of 47 mg/dL. The baboon died of acute renal failure 2 days later. Histological study of the perfused porcine liver showed marked microthrombi formation. In 3 of the later 5 cases, cross-circulation was discontinued when mild macroscopic hemolysis was observed. The duration of the 5 cross-circulations was maximally 6 hours (mean, 4.4 +/- 1.2 [SD] hours). Mean s-Hb concentration in the 5 cases was elevated to 14.8 +/- 5.8 mg/dL at the end of cross-circulation and decreased to the baseline level within 24 hours. These 5 baboons survived without organ dysfunction or immunologic disturbance. When severe hemolysis is avoided, direct cross-circulation using the ECLP system can be achieved without serious complications in nonhuman primates.  (+info)

Pulmonary vasoconstriction during regional nitric oxide inhalation: evidence of a blood-borne regulator of nitric oxide synthase activity. (3/42)

BACKGROUND: Inhaled nitric oxide (INO) is thought to cause selective pulmonary vasodilation of ventilated areas. The authors previously showed that INO to a hyperoxic lung increases the perfusion to this lung by redistribution of blood flow, but only if the opposite lung is hypoxic, indicating a more complex mechanism of action for NO. The authors hypothesized that regional hypoxia increases NO production and that INO to hyperoxic lung regions (HL) can inhibit this production by distant effect. METHODS: Nitric oxide concentration was measured in exhaled air (NO(E)), NO synthase (NOS) activity in lung tissue, and regional pulmonary blood flow in anesthetized pigs with regional left lower lobar (LLL) hypoxia (fraction of inspired oxygen [FIO2] = 0.05), with and without INO to HL (FIO2 = 0.8), and during cross-circulation of blood from pigs with and without INO. RESULTS: Left lower lobar hypoxia increased exhaled NO from the LLL (NO(E)LLL) from a mean (SD) of 1.3 (0.6) to 2.2 (0.9) parts per billion (ppb) (P < 0.001), and Ca2+-dependent NOS activity was higher in hypoxic than in hyperoxic lung tissue (197 [86] vs. 162 [96] pmol x g(-1) x min(-1), P < 0.05). INO to HL decreased the Ca2+-dependent NOS activity in hypoxic tissue to 49 [56] pmol x g(-1) x min(-1) (P < 0.01), and NO(E)LLL to 2.0 [0.8] ppb (P < 0.05). When open-chest pigs with LLL hypoxia received blood from closed-chest pigs with INO, NO(E)LLL decreased from 2.0 (0.6) to 1.5 (0.4) ppb (P < 0.001), and the Ca2+-dependent NOS activity in hypoxic tissue decreased from 152 (55) to 98 (34) pmol x g(-1) x min(-1) (P = 0.07). Pulmonary vascular resistance increased by 32 (21)% (P < 0.05), but more so in hypoxic (P < 0.01) than in hyperoxic (P < 0.05) lung regions, resulting in a further redistribution (P < 0.05) of pulmonary blood flow away from hypoxic to hyperoxic lung regions. CONCLUSIONS: Inhaled nitric oxide downregulates endogenous NO production in other, predominantly hypoxic, lung regions. This distant effect is blood-mediated and causes vasoconstriction in lung regions that do not receive INO.  (+info)

Cardiac effects of clinically available Kampo medicine assessed with canine isolated, blood-perfused heart preparations. (4/42)

Cardiac effects of 10 kinds of clinically available Kampo medicines were investigated: Kakkon-to (TJ-1), Dai-saiko-to (TJ-8), Boi-ogi-to (TJ-20), Chorei-to (TJ-40), Rokumi-gan (TJ-87), Tsu-do-san (TJ-105), Gosha-jinki-gan (TJ-107), San'o-shashin-to (TJ-113), Sairei-to (TJ-114) and Inchin-gorei-san (TJ-117). Chronotropic and inotropic effects were studied using canine isolated, blood-perfused heart preparations, while subcellular mechanisms were analyzed by measuring the drug-induced changes of the adenylate cyclase activity in the canine ventricular membrane preparation. Intracoronary injections of TJ-1, TJ-20, TJ-105 and TJ-113 increased the sinoatrial rate and developed tension of papillary muscle in a dose-related manner, which was significantly attenuated by the pretreatment of the preparations with beta-blocker propranolol. Meanwhile, the other extracts hardly affected these parameters. TJ-1, TJ-20 and TJ-113 increased the adenylate cyclase activity in a dose-related manner, but their potency was significantly less compared with that by an equivalent concentration of isoproterenol. Moreover, TJ-105 did not increase the adenylate cyclase activity. These results suggest that the positive chronotropic and inotropic effects of TJ-1, TJ-20, TJ- 105 and TJ-113 may be exerted through the direct stimulation of the beta-adrenoceptor and/or the norepinephrine release from the postganglionic nerve terminals in the heart.  (+info)

Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations. (5/42)

Chronotropic, inotropic and coronary effects of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride, monohydrate), a specific inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK), were assessed using canine isolated, blood-perfused heart preparations. Y-27632 slightly enhanced sinoatrial automaticity and significantly increased coronary blood flow, while it decreased ventricular contraction. The concentrations of Y-27632 needed to cause the currently observed changes were similar to those inhibiting ROCK in a previous in vitro study. These results suggest that the constitutional ROCK in the heart mainly regulates the ventricular contractility and coronary vascular tone rather than the sinoatrial automaticity.  (+info)

Standardization of an isolated pig heart preparation with parabiotic circulation: methodological considerations. (6/42)

In the present study we standardized an experimental model of parabiotic circulation of isolated pig heart. The isolated heart was perfused with arterial blood from a second animal as support and submitted to regional ischemia for 30 min, followed by total ischemia for 90 min and reperfusion for 90 min. Parameters for measurement of ventricular performance using different indices measured directly or indirectly from intraventricular pressure were defined as: maximum peak pressure, final diastolic pressure, pressure developed, first derivative of maximum pressure (dP/dt max), first derivative of minimum pressure (dP/dt min), systolic stress of the left ventricle (sigmas), and maximum elastance of the left ventricle. Isolated hearts subjected to regional and global ischemia presented significant worsening of all measured parameters. Less discriminative parameters were dP/dt max and dP/dt min. Elastance was the most sensitive parameter during the reperfusion period, demonstrating an early loss of ventricular function during reperfusion. The model proved to be stable and reproducible and permitted the study of several variables in the isolated heart, such as ischemia and reperfusion phenomena, the effects of different drugs, surgical interventions, etc. The model introduces an advantage over the classical models which use crystalloid solutions as perfusate, because parabiotic circulation mimics heart surgery with extracorporeal circulation.  (+info)

Cross-circulation study of natriuretic factors in postobstructive diuresis. (7/42)

To study the role of circulating natriuretic factors in the postobstructive diuresis that occurs after relief of bilateral, but not unilateral ureteral ligation, cross-circulation was carried out between normal recipient rats and donor rats have either 24-h bilateral (BUL) or unilateral (UUL) ureteral ligation. With BUL donors, there was a rapid marked increase in sodium and water excretion in the recipient rats, sustained for 80-140 min, with a peak approximately 10 times control values. With UUL donors, no significant natriuretic response occurred. Changes in glomerular filtration rate, renal plasma flow, blood pressure, hematocrit, or circulating levels of aldosterone or Pitressin did not explain the diuresis-natriuresis produced by cross-circulation with BUL donors. Differences in the intrinsic renal damage produced by bilateral as compared to unilateral ureteral obstruction did not appear to account for this response, since UUL donors given an acute urea load and urine reinfusion caused a similar diuresis-natriuresis. Moreover, normal donor rats given a urea load also caused a diuresis-natriuresis nearly equal to that produced by BUL rats, and the relationship between increased urea excretion and sodium excretion or urine flow in the recipients was not different in the two groups. Total urine reinfusion for 3 h in donor rats produced a significant, although less marked, diuresis-natriuresis in recipient animals, with only a slight elevation of the blood urea nitrogen level, much less increase in urea excretion rate, and no significant relationship between urea excretion and sodium excretion or urine flow. The results indicate that potent natriuretic factors, which act by decreasing the tubular reabsorption of sodium and water, are present in the blood of rats with bilateral, but not unilateral, ureteral ligation. High blood and urine urea levels appear to be the factors responsible for the marked natriuresis-diuresis occurring in normal rats during cross-circulation with BUL donors, although suggestive evidence of other natriuretic factors in urine reinfused intravenously was also obtained. The data suggest that urea osmotic diuresis is an important mechanism for determining the striking difference between the postobstructive diuresis observed after relief of bilateral as compared to unilateral ureteral ligation.  (+info)

Detrimental effects after dobutamine infusion on rat left ventricular function: mechanical work and energetics. (8/42)

We have previously reported that continuous infusion of dobutamine into the coronary artery induces positive inotropic effects but induces no detrimental effects in cross-circulated, excised normal rat hearts and even in Ca2+ overload-induced contractile failing rat hearts. However, we hypothesized that some detrimental effects on left ventricular (LV) function are induced after continuous dobutamine infusion and the following clearance of blood dobutamine, as is the case after beta-adrenergic receptor stimulation. To test this hypothesis, we investigated LV mechanical work and energetics in the same type of preparations that underwent continuous dobutamine infusion and clearance of blood dobutamine. We found that both mean end-systolic pressure and systolic pressure-volume area (PVA; a measure of total mechanical energy per beat) at midrange LV volume were significantly (P < 0.01) decreased. The mean myocardial oxygen consumption per beat intercept, which is composed of for the total Ca2+ handling in excitation-contraction coupling and basal metabolism, of the and PVA linear relation was also significantly (P < 0.05) decreased (n=8). The mean slope of the linear relation was unchanged in such hearts. Post-dobutamine basal metabolism was unchanged (n = 5 of the 8 hearts). The moderate proteolysis of a cytoskeleton protein, alpha-fodrin was identified (n = 7 of the 8 hearts with the decreased intercept), after clearance of blood dobutamine. In agreement with our hypothesis, the detrimental effect of the post-beta-adrenergic receptor stimulation was induced by a moderate concentration of dobutamine; we found systolic dysfunction due to the impairment of Ca2+ handling in excitation-contraction coupling in the rat LV and proteolysis of a cytoskeleton protein, alpha-fodrin.  (+info)

Vaginal birth leads to changes in the development of offsprings microbiomes not seen among mice born via C-section, which researchers suspect might contribute to the weight differences.. 0 Comments. ...
The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.. ...
Damaged human lungs that have been rejected for organ transplantation could be reconditioned through the use of cross-circulation from a pig, research suggests.Despite advances in the field, lung
Although exercise reduces several cardiovascular risk factors associated with obesity/diabetes, the metabolic effects of exercise on the heart are not well known. This study was designed to investigate whether high intensity interval training (HIT) is superior to moderate intensity training (MIT) in counteracting obesity-induced impairment of left ventricular (LV) mechanoenergetics and function. Diet-induced obese C57BL/6J (DIO) mice, displaying a cardiac phenotype with altered substrate utilization and impaired mechanoenergetics, were subjected to a sedentary lifestyle or 8-10 weeks of isocaloric HIT or MIT. Although both modes of exercise equally improved aerobic capacity and reduced obesity, only HIT improved glucose tolerance. Hearts from sedentary DIO mice developed concentric LV remodelling with diastolic and systolic dysfunction, which was prevented by both HIT and MIT. Both modes of exercise also normalized LV mechanical efficiency and mechanoenergetics. These changes were associated ...
Cardiac twitch contractions were simulated by Huxleys sliding filament crossbridge muscle model. Huxleys model was extended to include cardiac twitch contractions with a model structure having...
Ensuring the safe treatment of canine patients is the goal of a community-based, volunteer canine blood-donor program at K-State.
3 patients were enrolled in each of 3 study cohorts. There three cohorts were given differing, incrementally larger doses of this phase I drug. The same safety measures are being obtained on all patients. Efficacy measures were individualized as enrolllees do not have the same underlying vascular anomaly. The study is structured to include a 24 month drug-phase and a 24 month follow-up phase. The study is now closed to enrollment ...
parabiosis definition: 1. the union of two animals, naturally or experimentally, as by blood circulatory connections 2. the temporary and reversible suspension of a vital life process 3. the living together of two or more different species, as in mixed f...
Parabiosis and young blood transfusion have remarkable anti-aging effects. How to replicate the anti-aging effects of parabiosis and young blood transfusion
Two-dimensional echocardiography can provide serial cross-sectional images of the left ventricular cavity. We examined whether such serial images from steady-state ejecting hearts would allow three-dimensional reconstruction and accurate volume estimation without major geometric assumptions. Cross-circulated, paced dog hearts were suspended in a blood-filled tank. Serial cross-sectional images were taken at 3-mm intervals along the vertical axis. Left ventricular cavity and muscle areas of each image were planimetered with a light-pen system and summated for volume: total volume = sigma (areas x 3 mm). Direct left ventricular volume was measured through the cardiac cycle with a volumetric chamber connected to a balloon in the ejecting left ventricle. In six hearts, 67 separate direct volume measurements (range 9.5--54.7 ml) from various points in the cardiac cycle were compared with the simultaneous echo volume measurements. By least squares linear regression, echo volume = 1.01 (direct volume) ...
Peroxynitrite (ONOO−) is widely recognized as a mediator of NO· toxicity, but recent studies have indicated that this compound may also have physiologic activity and induces vascular relaxation as well as inhibition of platelet aggregation and neutrophil adhesion. The present experiment was designed to determine whether ONOO− may exert different effects on postischemic myocardial injury in a crystalloid perfusion environment versus a blood perfusion environment and, if it does, to clarify the mechanisms causing any differences. In Krebs-Henseleit buffer-perfused rabbit hearts, administration of ONOO− at the onset of reperfusion enhanced myocardial injury in a concentration-dependent fashion with a significant effective concentration of 30 μM. In contrast, in blood-perfused hearts, administration of ONOO− (1 to 30 μM) significantly attenuated postmyocardial injury as evidenced by improved cardiac function recovery, preserved endothelial function, decreased myocardial creatine kinase ...
Leviticus 17:11: For the life of the flesh is in the blood: and I have given it to you upon the altar to make an atonement for your souls: for it is the blood that maketh an atonement for the soul.. The Oxford Dictionary of Biology defines blood as a fluid body tissue that acts as a transport medium within an animal. The heart dilates and contracts, sending blood coursing through veins and arteries, delivering oxygen and nutrients to tissues and organs, and carrying waste matter from the center to the periphery for elimination.. A new frontier in parabiosis (the anatomical joining of two individuals, especially artificially in physiological research), known as heterochronic parabiosis, entails flooding an older organism with blood from a younger organism.. In heterochronic parabiosis, plasma (clear, yellowish fluid of vertebrates) is separated out from the blood whole and combined with platelets, before the combined fluids are delivered to the recipients circulatory system (arteries, ...
Theyve been dubbed blood slaves. Rows of sleek greyhounds peeking, wide-eyed, from wire pens. They escaped the punishing racing world to be kept captive in closed-colony animal blood banks for as long as a year. Theyre bled every couple of weeks - sometimes more frequently - and their blood is sold for millions of dollars to animal hospitals, which use it for surgeries that save other animals lives.. Closed colonies are the only legal way to obtain vital animal blood in California - a practice denounced as cruel and inhumane by activists whove been trying to end it for years. In 2019, they came quite close: A bill that would have legalized a human-like, volunteer animal blood donation system sailed through the Legislature with unanimous support and landed on the governors desk - where it was vetoed by Gov. Gavin Newsom because it didnt go far enough. I ask that the Legislature send me legislation that effectively leads to the phasing-out of closed colonies, Newsom said.. Enter ...
Schuurman, R., Brambilla, D., De Groot, T., Huang, D., Land, S., Bremer, J., ... Boucher, C. (2002). Underestimation of HIV Type I drug resistance mutations: Results from the ENVA-2 genotyping proficiency program. AIDS Research and Human Retroviruses, 18, 243 - 48. ...
So maybe Count Dracula had it right after all. It looks like that young blood has some really good stuff in it. The lab of Tony Wyss-Coray at Stanford has been studying the causes of the aging of the brain. As baby boomers get older and older they get more and more interested in how to keep their brains young.. The Wyss-Coray lab used parabiosis to see if there might be something in the blood that regulates brain aging. Parabiosis is a surgical technique that connects the circulatory systems of two mice. It is sort of like taking two mice and turning them into Siamese twins. Sorry mice, Im sure it is no fun, but it is for the sake of science. For controls they connected young mice to young mice, and old mice to old. Not surprisingly, nothing much happened. But when they connected young mice to old mice, Eureka! The brains of the old mice started behaving like they were much younger! The brain stem cells, which normally slow down in old mice, became active and divided more. Neurogenesis, the ...
So maybe Count Dracula had it right after all. It looks like that young blood has some really good stuff in it. The lab of Tony Wyss-Coray at Stanford has been studying the causes of the aging of the brain. As baby boomers get older and older they get more and more interested in how to keep their brains young.. The Wyss-Coray lab used parabiosis to see if there might be something in the blood that regulates brain aging. Parabiosis is a surgical technique that connects the circulatory systems of two mice. It is sort of like taking two mice and turning them into Siamese twins. Sorry mice, Im sure it is no fun, but it is for the sake of science. For controls they connected young mice to young mice, and old mice to old. Not surprisingly, nothing much happened. But when they connected young mice to old mice, Eureka! The brains of the old mice started behaving like they were much younger! The brain stem cells, which normally slow down in old mice, became active and divided more. Neurogenesis, the ...
Pressure unloading represents the only effective therapy in increased afterload-induced left ventricular hypertrophy (LVH) as it leads to myocardial reverse remodeling (reduction of increased left ventricular mass, attenuated myocardial fibrosis) and preserved cardiac function. However, the effect of myocardial reverse remodeling on cardiac mechanoenergetics has not been elucidated. Therefore, we aimed to provide a detailed hemodynamic characterization in a rat model of LVH undergoing pressure unloading. Pressure overload was induced in Sprague-Dawley rats by abdominal aortic banding for 6 (AB 6th week) or 12 weeks (AB 12th week). Sham operated animals served as controls. Aortic debanding procedure was performed after the 6th experimental week (debanded 12th week) to investigate the regression of LVH. Pressure unloading resulted in significant reduction of LVH (heart weight/tibial length ratio: 0.38±0.01 vs. 0.58±0.02g/mm, cardiomyocyte diameter: 18.3±0.1 vs. 24.1±0.8µm debanded 12th week ...
The aim of the present study was to characterize the mechanoenergetic alterations in a rat model of LVH undergoing pressure unloading therapy using LV P-V analysis method. According to our best knowledge, this is the first study demonstrating that the regression of LVH by pressure unloading leads not only to reversed myocardial contractility augmentation and restored diastolic function, but also to maintained cardiac mechanoenergetics.. According to Laplaces law, when the pathological stimulus of sustained pressure overload emerges, the myocardial wall thickness increases to normalize wall tension (18). This maladaptive response reaction, also known LVH, is characterized by increased expression of sarcomeric proteins with subsequent enlargement of the cardiomyocytes, ECM remodeling (10), and decreased capillary density (39). The reversibility of these alterations has been already proven by numerous previous works, since they demonstrated that the regression of preestablished pathological ...
This paper reveals several unexpected characteristics of the recirculation and homing pattern of NKT cells and elucidates key biochemical and molecular mechanisms underlying these unusual properties. Although sinusoidal retention and crawling are well documented behaviors for many cell types, this mode of locomotion is transient, limited to the acute phase of immune response for effector T cells (Bartholomäus et al., 2009), monocytes (Auffray et al., 2007), and PMNs (Phillipson et al., 2006; McDonald et al., 2010) invading an organ or to a maturation step for immature B cells in the bone marrow (Pereira et al., 2009). In the case of NKT cells (Geissmann et al., 2005), the results of the long-term parabiosis experiments presented in this study imply that this behavior can be prolonged for weeks and, therefore, that these innate-like lymphocytes constitutively wander within the confines of the sinusoid capillary bed of the liver for periods of time that can exceed their lifespan. This is ...
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TY - JOUR. T1 - Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. AU - Chen, Jiankang. AU - Chen, Jianchun. AU - Neilson, Eric G.. AU - Harris, Raymond C.. PY - 2005/12/9. Y1 - 2005/12/9. N2 - Loss of functioning nephrons stimulates the growth of residual kidney tissue to augment work capacity and maintain normal renal function. This growth largely occurs by hypertrophy rather than from hyperplasia of the remaining nephrons. The signaling mechanisms that increase RNA and protein synthesis during compensatory renal hypertrophy are unknown. This study found that the remaining kidney hypertrophied 42% by 16 d after unilateral nephrectomy (UNX) in DBA/2 mice. Immunoblotting analysis revealed increased phosphorylation of the 40S ribosomal protein S6 (rpS6) and the eukaryotic translation initiation factor (eIF) 4E-binding protein 1 (4E-BP1), the two downstream effectors of the mammalian target of rapamycin (mTOR). The highly specific mTOR inhibitor rapamycin blocked ...
Using an isolated canine heart preparation, the myocardial norepinephrine pool was labeled by injecting tritiated norepinephrine into the blood perfusing the heart. The extraction of the norepinephrine during a single circulation through the coronary bed was shown to be large (74%). As the isotopic material, which was extracted, was released spontaneously from the norepinephrine pool 75% to 88% of it was metabolized before appearing in the coronary venous blood. The chief metabolite has been demonstrated to be normetanephrine which accounts for 39.0% to 61.7% of the spontaneously released norepinephrine. Because of this it is concluded that catechol-O-methyl transferase is the enzyme primarily responsible for the metabolic inactivation of norepinephrine in the canine heart. When release was increased by the injection of tyramine, more of the released norepinephrine appeared unmetabolized in coronary venous blood, suggesting that the enzymatic process by which norepinephrine is inactivated may be ...
TY - JOUR. T1 - The harmful effects of ventricular distention during postischemic reperfusion. AU - Lucas, S. K.. AU - Schaff, H. V.. AU - Flaherty, J. T.. AU - Gott, Vincent L. AU - Gardner, T. J.. PY - 1981. Y1 - 1981. N2 - To assess the effects of left ventricular distention during the early reperfusion period following ischemic arrest, 16 canine heart preparations were subjected to 45 minutes of hypothermic (27°C) cardioplegic arrest and normothermic reperfusion. Isovolumic left ventricular developed pressure and rate of rise of left ventricular pressure (dP/dt) were measured with an intraventricular balloon; endocardial/epicardial flow ratios were determined with microspheres; and myocardial gas tensions were monitored with mass spectrometry. During early reperfusion, Group 1 hearts (n=8) were not distended (end-diastolic pressure = 0). Group 2 hearts (n = 8) were subjected to an enddiastolic pressure of 20 mm Hg for the initial 15 minutes of reperfusion. Group 2 hearts demonstrated ...
Lung transplantation, the only life-saving therapy for an increasing population of patients with end-stage lung disease, is severely limited by the number of available donor organs. Currently, up to 80% of donor lungs are rejected for serious but potentially reversible injuries. Since the beginning of transplantation in 1960s, clinicians and scientists have been trying to address the critical shortage of donor organs.. Now, a multidisciplinary team from Columbia Engineering and Vanderbilt University has - for the first time - demonstrated in a clinically relevant model that severely damaged lungs can be regenerated to meet transplantation criteria. In a study, the researchers describe the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient for 36 to 56 hours.. As Brandon Guenthart, a lead author of the study, explains to support lung recovery and to demonstrate cellular regeneration, we had to pursue a radically different ...
Paniz Kamran is the author of this article in the Journal of Visualized Experiments: 마우스의 Parabiosis : 자세한 프로토콜
Teri Sforza is one of the lead reporters on the OCR/SCNG probe of fraud, abuse and death in the Southern California addiction treatment industry. Our Rehab Riviera coverage won first place for investigative reporting from the California Newspaper Publishers Association, first place for projects reporting from Best of the West and is a finalist for the National Institute for Health Care Management Foundations print award, competing with the New York Times, the Washington Post and ProPublica. Sforza birthed the Watchdog column for The Orange County Register in 2008, aiming to keep a critical (but good-humored) eye on governments and nonprofits, large and small. It won first place for public service reporting from the California Newspaper Publishers Association in 2010. She also contributed to the OCRs Pulitzer Prize-winning investigation of fertility fraud at UC Irvine, covered what was then the largest municipal bankruptcy in Americas history, and is the author of The Strangest Song, the ...
You know how important human blood donors are. The same applies in veterinary medicine. Heres a look at donor dogs, blood banks and how the process works.
An isolated blood-perfused pig heart preparation to study myocardial perfusion with blood-pool gadolinium-chelate enhanced ultrafast MRI. High-power gradient MR- ...
Grant] United States / NCI NIH HHS / CA / CA03161; United States / NCI NIH HHS / CA / CA05587; United States / NCI NIH HHS / CA / CA11233; United States / NCI NIH HHS / CA / CA15089; United States / NCI NIH HHS / CA / CA20549; United States / NCI NIH HHS / CA / CA25408; United States / NCI NIH HHS / CA / CA28383; United States / NCI NIH HHS / CA / CA28476; United States / NCI NIH HHS / CA / CA29139; United States / NCI NIH HHS / CA / CA30696; United States / NCI NIH HHS / CA / CA32053; United States / NCI NIH HHS / CA / CA33603; United States / NCI NIH HHS / CA / CA35587; United States / NCI NIH HHS / CA / CA69177; United States / NCI NIH HHS / CA / ...
As professional mariners know, the use of drugs or alcohol while working on the water can result in a lost license and a lost livelihood. This article is the first in a series addressing these issues, and discussing the defense of a mariners license against prosecution by the United States Coast Guard (USCG) for the use of illicit drugs. Here, we provide an overview of drug testing procedures and the Sweeny Cure process that allows mariners to get back on the water after a negotiated settlement with the Coast Guard.. Overview. Maritime safety is a foremost concern for all who make their living on Americas waterways. One of the tools utilized by the USCG to ensure the highest quality of that safety is through the periodic drug testing of certain maritime employees, including anyone with a USCG issued document, credential, or license. The USCGs drug testing program is based, in part, upon criteria from the Department of Transportation (DOT). According to the DOT, dangerous drugs ...
FDA-approved & Passed Phase I Drug Library. A unique collection of 3175 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS).. ...
FDA-approved & Passed Phase I Drug Library. A unique collection of 3176 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS).. ...
The DEA announced the popular herbal analgesic kratom would be classified as a Schedule I drug in September 2016, despite public outcry and scant evidence of danger.
New Japan Pro Wrestling (新日本プロレス Shin Nihon Puroresu) − japońska federacja wrestlingu założona w styczniu 1972 roku przez Antonio Inokiego. W 2005 roku Inoki sprzedał federację dla firmy Yukes, która w 2012 roku sprzedała ją dla Bushiroad. Obecnie prezesem federacji jest Naoki Sugabayashi (od września 2013)[2], a prezydentem Katsuhiko Harada (od lutego 2016)[3]. NJPW jest największą federacją wrestlingu w Japonii i drugą na świecie (po WWE). W latach 1972-1986 federacja należała do National Wrestling Alliance. Największą galą NJPW jest January 4 Dome Show, która jest organizowana od 1992 roku. Od 2007 roku gala jest nazywana Wrestle Kingdom. Głównym bookerem federacji jest Gedo[4]. 1 grudnia 2014 roku powstała platforma internetowa NJPW World, na której możliwe jest oglądanie gal federacji[5]. ...
Canine heart disease can be easily overlooked unless the pet parent is aware of the early warning signs. Learn to recognize the indicators of heart issues.
Real people, Real dogs, Real recoveries! Canine Heart Disease- Alternative treatments and therapies for dogs suffering from valvular disease to dilated cardiomyopathy.
Fibrosis is the common final pathway of virtually all chronic injury to the kidney. While it is well accepted that myofibroblasts are the scar-producing cells in the kidney, their cellular origin is still hotly debated. The relative contribution of proximal tubular epithelium and circulating cells, including mesenchymal stem cells, macrophages, and fibrocytes, to the myofibroblast pool remains highly controversial. Using inducible genetic fate tracing of proximal tubular epithelium, we confirm that the proximal tubule does not contribute to the myofibroblast pool. However, in parabiosis models in which one parabiont is genetically labeled and the other is unlabeled and undergoes kidney fibrosis, we demonstrate that a small fraction of genetically labeled renal myofibroblasts derive from the circulation. Single-cell RNA sequencing confirms this finding but indicates that these cells are circulating monocytes, express few extracellular matrix or other myofibroblast genes, and express many ...
Hypertension can lead to hypertrophic heart disease is a multi-factorial, multi-scale problem in which altered whole body hemodynamics and neurohormonal factors lead to a complex growth and remodeling response in the heart. The cells and extracellular matrix in the myocardium initially compensate to the abnormal environmental factors with altered gene expression, changes in contractile and mechanoenergetic function, cell and tissue structural remodeling, in turn further affecting circulatory dynamics and often leading to decompensation and failure. The goal of this project is to integrate novel cell signaling models of myocyte hypertrophy into organ-level continuum models of ventricular growth, remodeling and mechanoenergetics coupled to hemodynamic models of systemic hypertension, and validate these multi-scale models with experiments in rats subjected to ventricular hemodynamic overload and treated with drugs that target key response pathways. The resulting model systems will enable ...
Twenty-five pairs of male rabbits of the same variety and strain were joined together in aural parabiosis for 13 to 15 days and then separated from one another.
All three papers come from a line of research called parabiosis. Circulatory systems of a young mouse and an old mouse are surgically joined so that the blood circulating in the veins of the old mouse comes half from the young mouse. The finding from the Conboy Lab in 2005 is that the old mouse is rejuvenated in significant ways. Research since then has sought to separate which factors in the blood are responsible for this effect. Irina Conboy told me last month she has identified 6 key molecules, some of which need to be added, others either removed or de-activated.. Paper #1: (out of Stanford and UCSF and the Palo Alto Center for Regenerative Medicine) Here we report that exposure of an aged animal to young blood can counteract and reverse pre-existing effects of brain aging at the molecular, structural, functional and cognitive level. Exactly which chemical compounds was not determined, but the benefit was seen both in growth of new neurons in the brain, and also in oberved behavioral ...
The isolated blood-perfused preparations of canine atrium were suspended in a bath and perfused with arterial blood led from the carotid artery of the heparinized donor dog. Disopyramide caused dose-related negative chronotropic and inotropic effects in a dose range of 30-1000 microgram when injected directly into the cannulated sinus node artery of the isolated atrium. The order of potencies for inducing the negative chronotropic effect in isolated atrium preparations was verapamil greater than propranolol greater than lidocaine = quinidine greater than phenytoin greater than or equal to disopyramide greater than procainamide. On the other hand, the order of potencies for inducing the negative inotropic effect was verapamil = propranolol greater than lidocaine greater than or equal to phenytoin greater than disopyramide greater than procainamide greater than or equal to quinidine. When disopyramide (1 mg/kg or 3 mg/kg) was administered i.v. into the jugular vein of the donor dog, the systemic ...
Occasionally during an emergency or for a serious illness a dog may require a lifesaving blood transfusion. This is most commonly needed due to internal organ bleeding caused by trauma, from ingesting a toxin, particularly rat baits or illnesses like anaemia.. Some veterinary clinics have their own canine blood bank set up with stores of blood on hand for these situations. Other veterinary clinics may have a list of potential blood donor candidates that they can call on to give blood in the case of emergency. Like humans, dogs do have different blood types and can even have more than one blood type in their system. Cross matching of blood type between donor and recipient will be undertaken before giving a transfusion.. The process of taking the blood is usually fairly simple and can be done on most dogs without sedating them. The process involves very little discomfort but the dog will be required to sit still and calm for up to 15 minuets while the blood is being drawn. An ideal blood donor ...
TY - CHAP. T1 - Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism. AU - Mota, Cristiano. AU - Santos-Silva, Teresa Sacadura. AU - Terao, Mineko. AU - Garattini, Enrico. AU - Romão, Maria João. AU - Leimkühler, Silke. PY - 2019/6/27. Y1 - 2019/6/27. N2 - This chapter discusses the significance of aldehyde oxidases for the design and development of new drugs, and discusses associated problems. Aldehyde oxidases are a group of enzymes with important functions in the context of drug and xenobiotic metabolism. Aldehyde oxidases (AOXs) and xanthine oxidoreductases (XORs) are structurally and evolutionarily linked molybdoflavoproteins. AOXs and XORs are widely distributed throughout all kingdoms of life, homologous proteins have been identified in many eukaryotic and prokaryotic organisms. The C-terminal domain III is binding the molybdenum cofactor (Moco) in its sulfido-containing form. At the catalytic site, the Moco adopts an approximately square pyramidal geometry. Heterologous expression ...
BioCytics© was incorporated in 2005 in Huntersville, North Carolina. It is being incubated by Carolina BioOncology Institute (CBI), a cancer treatment and Phase I drug testing facility. BioCytics© was founded by Dr. John Powderly, MD, medical board certified oncologist and a certified physician investigator (CPI), who is also President of CBI.. ...
Taylor has been on my back to make some Apple Cinnamon Muffins. I dont know why I drug my feet making them for her. Probably because I dont like having around a ton of sweets. What I really like about these muffins, is that if you keep them in the freezer and pull them out one at a time and heat up in the toaster oven, they make for a great treat with your morning coffee or tea. I tried to healthy them up a bit by using coconut flour. Apples, Cinnamon and Coconut are all good for you. Yes, there is sugar and I would still consider this to be a splurge, but sometimes a splurge is just what you need. These turned out light and fluffy and scrumptious. ...
by Dog Spectrum.com , Nov 3, 2016 , Tips. Althоugh thеrе is no cure fоr thе common саuѕеѕ of hеаrt fаilurе in dоgѕ, thеrе аrе treatments available thаt саn grеаtlу improve and еxtеnd уоur dоgѕ lifе. If уоur dog has bееn diаgnоѕеd with hеаrt fаilurе аnd clinical signs аrе viѕiblе, it is likеlу that your ...
While there is no cure for CHF caused by MMVD, management of heart failure is the most common approach, usually through the use of daily medication.
Drug testing in the home and the workplace has become a necessity because of widespread prescription drug abuse. Families are deteriorating because of loved ones becoming addicted to illicit and prescription drugs. Drug abuse often starts at the bathroom cabinet. Check it regularly and dispose of outdated or unfinished prescriptions in a responsible way.. The average employer is unknowingly wasting thousands of dollars a year due to drug related workplace issues. Drug testing your employees saves lives and helps prevent addiction.. Every drug test kit supplied by us is made to the highest standard ensuring the result is as reliable and accurate as the last. Always follow manufacturers recommendations when testing, otherwise you may get an erroneous result. ...
TY - JOUR. T1 - Structural changes in the proximal tubule of kidneys from hypophysectomized rats.. AU - Evan, Andrew. AU - Simone, P. G.. AU - Solomon, S.. AU - Loker, E. F.. PY - 1972/10. Y1 - 1972/10. UR - http://www.scopus.com/inward/record.url?scp=0015414239&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015414239&partnerID=8YFLogxK. M3 - Article. C2 - 5077377. AN - SCOPUS:0015414239. VL - 174. SP - 265. EP - 277. JO - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. JF - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. SN - 0003-276X. IS - 2. ER - ...
The ability of a numerical procedure to detect and to localize two experimentally induced, epicardial dipolar generators was tested in 24 isolated, perfused rabbit heart preparations, suspended in an electrolyte-filled spherical tank. Electrocardiograms were recorded from 32 electrodes on the surface of the test chamber before and after placement of each of two epicardial burns. The second lesion was located either 180 degrees, 90 degrees, or 45 degrees from the first. Signals were processed by iterative routines that computed the location of one or two independent dipoles that best reconstruced the observed surface potentials. The computed single dipole acounting for 99.68% of root mean sequare (RMS) surface potential recorded after the first burn was located 0.26 +/- 0.10 cm from the centroid of the lesion. Potentials recorded after the second lesions were fit with two dipoles that accounted for 99.36 +/- 1.51% of RMS surface potentials and that were located 0.42 +/- 0.26 cm and 0.57 +/- 0.49 ...
"Circulation. 116: 443. Archived from the original on 15 October 2015.. *^ Loria V, Dato I, Graziani F, Biasucci LM (2008). " ... "Southern Cross Healthcare Group. Archived from the original on 3 March 2014. Retrieved 15 September 2013.. ... "Circulation. 102 (10): 1082-85. doi:10.1161/01.CIR.102.10.1082. PMID 10973834. Archived from the original on 5 July 2011.. ... "Circulation: Cardiovascular Quality and Outcomes. 9 (3): 257-264. doi:10.1161/CIRCOUTCOMES.115.002224. PMC 4940126 . PMID ...
Southern Cross Healthcare Group. [15 September 2013].. *^ Faxon, D. P. Atherosclerotic Vascular Disease Conference: Executive ... Circulation. 1 June 2004, 109 (21): 2595-2604. PMID 15173041. doi:10.1161/01.CIR.0000128517.52533.DB.. ... Southern Cross Healthcare Group. [15 September 2013]. (原始内容存档于2014年3月3日).. ... Circulation. 1 June 2004, 109 (21): 2595-2604. doi:10.1161/01.CIR.0000128517.52533.DB.. ...
Ballou LM, Cross ME, Huang S, et al. (2000). "Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 ... 1999). "Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age". Circulation. 100 ( ...
Underwood and Cross, James (2009). General and Systematic Pathology. London, UK: Churchhill livingstone. p. 279. Kannel WB, ... Meta-analysis of prospective studies". Circulation. 102 (10): 1082-5. doi:10.1161/01.CIR.102.10.1082. PMID 10973834. Smolders B ... McPherson R, Tybjaerg-Hansen A (February 2016). "Genetics of Coronary Artery Disease". Circulation Research. 118 (4): 564-78. ... Circulation. 108 (21): 2619-23. doi:10.1161/01.CIR.0000097116.29625.7C. PMID 14597589. Dai X, Wiernek S, Evans JP, Runge MS ( ...
"The American Red Cross 2005 Guidelines for Emergency Care and Education" (PDF). American Red Cross. 2005. pp. 1-31. Archived ... Wilkes-Barre News, August 22, 2007 "Part 10.3: Drowning". Circulation. 112 (24): 133-135. November 25, 2005. doi:10.1161/ ... From 1976 to 1985, the choking-rescue guidelines of the American Heart Association and of the American Red Cross taught ... From 1986 to 2005, the published guidelines of the American Heart Association and the American Red Cross recommended only the ...
Teng, G. Q; Zhao, X; Lees-Miller, J. P; Quinn, F. R; Li, P; Rancourt, D. E; London, B; Cross, J. C; Duff, H. J (2008). " ... Circulation Research. 103 (12): 1483-91. doi:10.1161/CIRCRESAHA.108.177055. PMC 2774899. PMID 18948620. Than, B. L; Goos, J. A ... Circulation Research. 106 (8): 1342-50. doi:10.1161/CIRCRESAHA.109.213132. PMC 2869449. PMID 20339120. Shu, X; Cheng, K; Patel ...
In 1973, the American Red Cross complained that the orange cross too closely resembled their logo of a red cross on a white ... doi:10.1001/archpedi.1964.02080060441001 "Association Acts to Promote Medical Identification Symbol". Circulation. 30 (1): 7. ... Prior to the development of the Star of Life, American ambulances most commonly were designated with a safety orange cross on a ... The symbol was promoted by the American Red Cross and rapidly adopted worldwide as an emergency medical symbol. In 1970, when ...
The 1977 Deerfield boys cross country team is regarded by at least one publication as one of the single greatest prep cross ... 1] "Renovation improves circulation". Archived from the original on 2011-07-07. Retrieved 2006-01-29. Letter to Junior Parents ... XCNation: The Cross County Chronicle. Archived from the original on 18 July 2011. Retrieved 14 July 2011. DEERFIELD, Illinois: ... cross country, golf, gymnastics, soccer, swimming and diving, tennis, track & field, volleyball, and water polo. Men may also ...
Two cross-shafts and two upright cross-slabs are on display in the Govan Old museum. The two cross-shafts include the iconic ... Glasgow: For private circulation. Foster, Sally (March 2015). "Circulating Agency: The V&A, Scotland and the multiplication of ... Of the thirty-one monuments on display at Govan Old, there is one sarcophagus, two cross-shafts, two upright cross-slabs, five ... p. 3. Fisher, Ian (1994). "The Govan cross-shafts and early cross-slabs". In Ritchie, Anna (ed.). Govan and its early medieval ...
A cross-section of siliceous nodule, resembling the flint found in higher limestones. A quartz nodule. Variations in the ... Water circulation was variably restricted. Large amounts of sand-sized to granule-sized fusulinids, identified as Schwagerina ... The southern shelly ranges were deposited in a less turbulent and deeper-water environment, having good circulation and ...
"Cross platform circulation certificate" (PDF). Audit Bureau of Circulation. Retrieved 7 May 2013. "Judge critiques". The Kennel ... Dog World has traditionally published a wide cross section of opinion and has often taken issue with the Kennel Club (KC). ... The Audit Bureau records a 98.8 per cent purchased average circulation figure of 11,700 print copies each week throughout 2012 ...
Blood circulation and oxygenation are required to transport oxygen to the tissues. The physiology of CPR involves generating a ... Andrew's First Aid; British Red Cross Society. Ali S, Athar M, Ahmed SM. A randomised controlled comparison of video versus ... In general, CPR is continued until the person has a return of spontaneous circulation (ROSC) or is declared dead. Play media ... If there is a Return of spontaneous circulation (ROSC), all organs can be considered for donation. If the patient does not ...
A ventricular assist device (VAD) is an electromechanical device for assisting cardiac circulation, which is used either to ... 2014). "Educational resources for patients considering a left ventricular assist device: a cross-sectional review of internet, ... Kirklin, JK; Naftel, DC (September 2008). "Mechanical circulatory support: registering a therapy in evolution". Circulation: ... might be necessary to resolve the problem of cardiac circulation. If both an LVAD and an RVAD is needed a BiVAD is normally ...
The circulation of De Tijd was 59,144 copies and its market share was 4.7% in 2002. The circulation of the paper was 39,315 ... 2014). "Does Media Cross-Ownership Translate into Cross-Promotion?". Journalism Studies. 16 (6): 868-886. doi:10.1080/1461670X. ... "National newspapers total circulation". International Federation of Audit Bureaux of Circulations. Retrieved 3 December 2014. ... It was 37,448 copies in 2010, 39,431 copies in 2011 and a total circulation of 41.065 (digital+print) in 2015. According to the ...
"Manga Cross". MangaCross.jp (in Japanese). Retrieved 20 September 2020. 虫ん坊 2013年4月号 (133). Tezuka Osamu Official (in Japanese ... Loo, Egan (18 January 2010). "2009 Japanese Manga Magazine Circulation Numbers". Anime News Network. Retrieved 2 August 2014. " ... Manga Cross (マンガクロス, Mangakurosu) - Weekly web comics (Tuesday and Thursday) Champion Red Ichigo (チャンピオンレッドいちご, Chanpion Reddo ...
Sir Ernest Shackleton's Imperial Trans-Antarctic Expedition sets sail on the Endurance from Plymouth in an attempt to cross ... The sovereign rapidly vanishes from circulation. 8 August First Defence of the Realm Act passed. ... Victoria Cross recipient (born 1834) 9 August - Henry Hadley, civilian shot in Germany (born 1863) 16 August - Mary Bird, ...
A clinical-radiological correlation study". Stroke: A Journal of Cerebral Circulation. 26 (6): 950-5. doi:10.1161/01.STR.26.6. ... Krasnianski, M; Neudecker, S; Zierz, S (Aug 2004). "[Classical crossed pontine syndromes]". Fortschritte der Neurologie · ... "The crossed paralyses. The original brain-stem syndromes of Millard-Gubler, Foville, Weber, and Raymond-Cestan". Archives of ...
Labor Notes is the largest circulation cross-union publication remaining in the United States. It reports news and analysis ... a b c Cross Currents. Labor unions in Japan. CULCON. Retrieved 11 June 2011 ... Unions may organize a particular section of skilled workers (craft unionism),[3] a cross-section of workers from various trades ... a cross-section of workers from various trades (general unionism, traditionally found in Australia, Belgium, Canada, Denmark, ...
Once the β-lactam ring binds to PBPs, cross-linking between peptidoglycan units is inhibited. Absorption: Once consumed, ... Cefuroxime is then released for systematic circulation. If cefuroxime axetil is given with food, absorption values can increase ...
In 2007 the circulation of Buffé was 1,996,900 copies, making it the best-selling magazine in Sweden. The circulation was ... Mikael Vemmenby (2011). "How Cross Media is used by ICA Supermarket to improve their Brand" (PDF). CHI. Retrieved 6 February ...
These innovations included: A natural circulation reactor plant. Her small reactor coolant pumps had two speeds: On and Off. ... The ability to cross connect main and auxiliary seawater systems. A directly coupled main engine turbine which avoided gear ...
The system initially struggled to organize; however, a closed circulation developed on August 23. The low-level circulation ... A tropical wave crossed Central America and emerged into the eastern Pacific basin on July 6. The wave moved slowly westward ... which displaced the mid-level circulation and deep convection from the low-level circulation. The National Hurricane Center ... A tropical wave crossed over Central America between August 28 and August 29. While south of Acapulco, it began showing signs ...
The 2002 circulation of De Morgen was 68,359 copies. Its market share in the same year was 5.4%. The circulation of De Morgen ... 2014). "Does Media Cross-Ownership Translate into Cross-Promotion?". Journalism Studies. 16 (6): 868-886. doi:10.1080/1461670X. ... During the first quarter of 2009 the paper had a circulation of 76,439 copies. Its total circulation was 58,496 copies in 2009 ... "National newspapers total circulation". International Federation of Audit Bureaux of Circulations. Retrieved 3 December 2014. ...
However, the column was caught in a machine gun cross-fire in a valley near Kuolemanlaakso, Finland at the Russian-Finish ... The German ostmark currency was put into circulation. Born: Joyce Ballantyne, American graphic artist, best known as the ... Finnish Civil War - Retreating Red Guards fought off White Guards as they attempted to cross Alvettula River, losing 150 men. ... Battle of Tampere - The White Guards crossed the Tammerkoski River dividing Tampere, Finland and reached the western half of ...
The magazine was in circulation between 2000 and 2008. Its main focus was music-based, in addition to videogame coverage, ... comedian interviews (David Cross, Lewis Black, etc.) and comics (Too Much Coffee Man). The bands Thursday (band), Thrice and ...
It was initially disorganized, without a well-developed circulation. On September 25, while still a tropical depression, the ... Without intensifying further, the depression crossed the northeastern Yucatán Peninsula on September 26. The next day, the ... On September 30, the circulation of Debbie dissipated just offshore Mississippi. Its remnants made landfall, accelerated ...
Cambridge: Cambridge University Press Jack Goody, Joan Buckley Cross-Sex Patterns of Kin Behavior: A Comment Cross-Cultural ... Goody, Jack; Goody, Esther (1 January 1967). "The Circulation of Women and Children in Northern Ghana". Man. 2 (2): 226-248. ... 304-345 JSTOR 177651 1969 Adoption in Cross-Cultural Perspective Comparative Studies in Society and History, Vol. 11, No. 1 ( ... Goody, Jack; Goody, Esther (1 January 1966). "Cross-Cousin Marriage in Northern Ghana". Man. 1 (3): 343-355. doi:10.2307/ ...
It maintains blood circulation in the brain and heart. However, the parts of the body below the balloon are cut off from the ... REBOA is considered a minimally-invasive alternative to thoracotomy with aortic cross-clamping (ACC). The technique involves ...
4m high wooden cross and a religious artwork Credo. The church is a center for the evangelical believers from the fourth ... Circulation is approximately 16,000 issues. Dúbravská televízia - Established in 1999, the local TV station broadcasts 24-hours ...
This enterohepatic circulation of bile acids allows a low rate of synthesis, only about 0.3g/day, but with large amounts being ... NAPE-PLD orchestrates a direct cross-talk between lipid amide signals and bile acid physiology.[13] ... All four of these bile acids recycled, in a process known as enterohepatic circulation.[2][3] ... As bile acids are made from endogenous cholesterol, disruption of the enterohepatic circulation of bile acids will lower ...
Allen G. Debus, Robert Fludd and the Circulation of the Blood, J Hist Med Allied Sci (1961) XVI (4): 374-393. doi: 10.1093/ ... It is now seriously doubted that any formal organisation identifiable as the "Brothers of the Rose Cross" (Rosicrucians) ever ... He was on good terms with Sir William Paddy.[5] Fludd was one of the first to support in print the theory of the circulation of ... Analysis of the Confession of the Rosy Cross) of 1615. Fludd returned to the subject at greater length, the following year.[2] ...
Plane light above, cross-polarized light below. Scale box is 0.25 mm. ... the process by which hydrothermal circulation cracks and brecciates the wall rocks and fills it in with veins. This is ...
"Circulation Coins: Five Rand (R5)". South African Mint Company. 2011. Retrieved 16 February 2014.. ... They never made such extensive migrations as the blue wildebeest, but at one time, they crossed the Drakensberg Range, moving ...
Dhallan left his position at Holy Cross in 2000 in order to start his own company, Ravgen, with the pursuit of developing a ... "JAMA Network , JAMA , Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal Circulation". Jama.ama- ... "Methods to Increase the Percentage of Free Fetal DNA Recovered from the Maternal Circulation". The Journal of the American ... PA before becoming an attending physician in the Department of Emergency Medicine at Holy Cross Hospital in Silver Spring, MD. ...
Similar circulations. Gustnado. Main article: Gustnado. A gustnado, or gust front tornado, is a small, vertical swirl ... They form over water similarly to mesocyclonic tornadoes, or are stronger tornadoes which cross over water. Since they form ... A multi-vortex structure can occur in almost any circulation, but is very often observed in intense tornadoes. These vortices ... Small-scale, tornado-like circulations can occur near any intense surface heat source. Those that occur near intense wildfires ...
... national cross sectional survey". BMJ. 335 (7619): 549. doi:10.1136/bmj.39315.670208.47. PMC 1976488. PMID 17827485.. ... "Circulation. 126 (18): 2177-83. doi:10.1161/CIRCULATIONAHA.112.121301. PMC 3501404. PMID 23109514.. ...
... ticks will tend not to cross it; acaricides may also be sprayed on it to kill ticks.[146] A sun-exposed tick-safe zone at least ... These animals seem to transmit spirochetes to ticks and thus participate in the natural circulation of B. burgdorferi in Europe ...
The difference between soft and hard body parts stems mostly from the fact that carbon has a very low X-ray cross section ... Angiogram showing a transverse projection of the vertebro basilar and posterior cerebral circulation. ... Any given point within the subject is crossed from many directions by many different beams at different times. Information ...
This was a commemorative issue not intended for regular circulation. A total of 25,265 coins were minted.[9] ...
Most of these blades in circulation stem from the 19th century. Another distinct form of art from Sanandaj is 'Oroosi', a type ... "Female genital mutilation among Iraqi Kurdish women: a cross-sectional study from Erbil city". BMC Public Health. 13: 809. doi ...
"Venturi or air circulation?, that's the question". face2fire (in Spanish). Retrieved 2019-07-14.. ... because the cross-sectional area at "1" is greater than at "2". ...
CirculationEdit. Early tetrapods probably had a three-chambered heart, as do modern amphibians and many reptiles, in which ... Tetrapods had a tooth structure known as "plicidentine" characterized by infolding of the enamel as seen in cross-section. The ... Holy Cross Mountains, Poland)". Palaeogeography, Palaeoclimatology, Palaeoecology. 420: 173-192. Bibcode:2015PPP...420..173N. ... a heart for circulation, and eyes and ears for seeing and hearing in air. ...
Cross-Currents: East Asian History and Culture Review. Vietnamese Academy of Social Sciences (11): 101. Retrieved 26 August ... The Hoa controlled nearly two-thirds of the amount of cash in circulation, 80 percent of the processing industry, 80 percent of ... claiming it was impossible for a Shu prince to cross thousands of miles, through forests and many states to invade Văn Lang.[23 ... "Cross-Border Brides: Vietnamese Wives, Chinese Husbands in a Border-Area Fishing Village" (PDF) ...
is typically 5 ml/ min (around 8 litres/ day), and the fluid is returned to the circulation via afferent and efferent ... Glomerular capillaries have a reflection coefficient close to 1 as normally no protein crosses into the glomerular filtrate. ... Albumin and other proteins in the interstitial spaces return to the circulation via lymph. ... and filtered fluid is mostly returned to the circulation via lymph nodes and the thoracic duct.[2] The mechanism for this "no ...
During an immune response, proinflammatory cytokines (e.g. IL-1) are released into the peripheral circulation system and can ... more research is needed to determine if the results seen in cross-generational animal models can be extended to humans. ... that the accumulation of stressors across a lifespan can enhance the development of psychopathology once a threshold is crossed ...
Symmetry: e.g., herpes zoster usually only affects one side of the body and does not cross the midline. ...
In May 1989, a charity version of the Gerry and the Pacemakers song "Ferry Cross the Mersey" was released in aid of those ... lung or blood circulation function for some time after being removed from the crush. The report stated that placing fans who ... "The Official Charts Company - Ferry Cross The Mersey by Gerry Marsden, Paul McCartney, Holly Johnson, The Christians and Stock ... its average circulation in Liverpool was 12,000 copies a day.[254][255] ...
"British Red Cross. Retrieved 15 May 2016.. *^ "Florence Nightingale Medal". International Committee of the Red Cross. 2003. ... Nightingale's note was in circulation alongside the images of Sir Isaac Newton, William Shakespeare, Charles Dickens, Michael ... Royal Red Cross (1883) Lady of Grace of the Order of St John (LGStJ) (1904) Order of Merit (1907). ... In 1883, Nightingale became the first recipient of the Royal Red Cross. In 1904, she was appointed a Lady of Grace of the Order ...
The city has been described as the "most unique"[6] in the United States,[7][8][9][10][11] owing in large part to its cross- ... in wide circulation is the Clarion Herald, the newspaper of the Roman Catholic Archdiocese of New Orleans. ... University of Holy Cross, a Catholic liberal arts college founded in 1916. ... Vertical cross-section, showing maximum levee height of 23 feet (7.0 m) ...
1876 as the 'Windham County Democrat'), a daily newspaper with a weekday circulation of just over 10,000,[83] and The Commons, ... Brattleboro is crossed by six highways, including one Interstate highway. They are: *. Interstate 91 ...
Continuing north on Route 25, the freeway ends as it crosses Route 111 and continues as a surface road towards I-84 in Newtown ... Annual circulation exceeds 373,000 transactions.[51] There are two branches of the library: *The Trumbull Library (main branch ...
An increase in the number of white blood cells in circulation is called leukocytosis.[14] This increase is most commonly caused ... Neutrophilia is an increase in the absolute neutrophil count in the peripheral circulation. Normal blood values vary by age.[15 ... Increased destruction of cells in peripheral circulation can stimulate bone marrow. This can occur in hemolytic anemia and ... The average lifespan of inactivated human neutrophils in the circulation has been reported by different approaches to be ...
First, in circulation in New York State since 1985, the Library has maintained the highest circulation of any city library in ... "Cross Bay Veterans Memorial Bridge". MTA Bridges and Tunnels. Retrieved July 5, 2016. In 1939 the New York City Parkway ... The IND Rockaway Line parallels the Cross Bay, has a mid-bay station at Broad Channel which is just a short walk from the ... The Cross Bay Veterans Memorial Bridge, built in 1939, traverses Jamaica Bay to connect the Rockaway Peninsula to Broad Channel ...
"Coronary heart disease - causes, symptoms, prevention"। Southern Cross Healthcare Group। ৩ মার্চ ২০১৪ তারিখে মূল থেকে আর্কাইভ ... "Circulation। 129 (14): 1483-92। doi:10.1161/circulationaha.113.004042। PMID 24573352। পিএমসি 4181359 ।. ... "The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study"। Circulation। 129 (14 ... Circulation। 109 (21): 2595-2604। doi:10.1161/01.CIR.0000128517.52533.DB। PMID 15173041।. ...
In 2006, Haugesunds Avis had a circulation of 33 448.[19] As of 2007, the executive editor is Tonny Nundal. The newspaper owns ... which actually crosses over slightly into the neighboring municipality of Karmøy, has a total of about 40,152 (of that 5,425 ...
... high levels of oxidative damage increases the degree of cross-linking between protein fragments, rendering the aggregates ... "Circulation. 121 (8): 997-1004. doi:10.1161/CIRCULATIONAHA.109.904557. PMC 2857348. PMID 20159828.. ...
In relation to dialect diversity, Romani works in the same way as most other European languages.[211] Cross-dialect ... For travellers, the administration counted 160,000 circulation titles in 2006 issued to people aged 16 to 80 years. Among the ... then crossed the Middle East and came into Europe.. ...
In the spring of that year, Sulla crossed the Adriatic with a large fleet from Patrae, west of Corinth, to Brundisium and ... The currency minted from this treasure was to remain in circulation for centuries and was prized for its quality. ... No general before him had ever crossed the city limits, the pomerium, with his army. Most of his commanders (with the exception ... Unable to leave a potentially dangerous army in his rear, Sulla crossed into Asia. He pursued Fimbria to his camp at Thyatira ...
... *Download PDF Copy ... A previous study from the team demonstrated a cross-circulation platform that maintained the viability and function of a donor ... We envision that interventional cross-circulation may be used to investigate regeneration of other damaged organs, such as ... In a study published today on Nature Communications website, the researchers describe the cross-circulation platform that ...
Cross-Reactivity of Anti-CagA Antibodies With Vascular Wall Antigens. Francesco Franceschi, Antonia R. Sepulveda, Antonio ... Cross-Reactivity of Anti-CagA Antibodies With Vascular Wall Antigens. Francesco Franceschi, Antonia R. Sepulveda, Antonio ... Cross-Reactivity of Anti-CagA Antibodies With Vascular Wall Antigens. Possible Pathogenic Link Between Helicobacter pylori ... Second, there was no evidence, until now, of H pyloris ability to spread from its gastric niche via the blood circulation. ...
Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person ... Two cases are described in which the systemic and pulmonary blood streams cross at atrioventricular level. One was examined ... Criss-Cross Atrioventricular Relationships Producing Paradoxical Atrioventricular Concordance or Discordance. ROBERT H. ... Criss-Cross Atrioventricular Relationships Producing Paradoxical Atrioventricular Concordance or Discordance. ROBERT H. ...
Blue Cross Blue Shield of Massachusetts is an Independent Licensee of the Blue Cross and Blue Shield Association.. ® Registered ... Blood circulation after birth. The closure of the ductus arteriosus, ductus venosus, and foramen ovale completes the change of ... About Blue Cross Blue Shield of Massachusetts Terms of Use, Privacy & Security Accessibility Nondiscrimination and Translation ... Blue Cross Blue Shield of Massachusetts is a leading provider of quality health insurance for residents of Massachusetts. Our ...
... the Fontan anastomosis has been thought to reflect flow efficiencies and to influence on hemodynamics in the Fontan circulation ... Quantitative Evaluation of Hemodynamics in the Fontan Circulation: A Cross-Sectional Study Measuring Energy Loss In Vivo. ... Q was calculated as the product of velocity and the cross-sectional area of the vessel lumen. The cross-sectional areas of the ... In the Fontan circulation, it is possible that EL itself can be an afterload in a serial circulation and can cause workload for ...
Cross-Border Circulation of Films and Cultural Diversity in the EU. Journal of Cultural Economics, 42:645-676 (2018) ... Alaveras, Georgios and Gomez-Herrera, Estrella and Martens, Bertin, Cross-Border Circulation of Films and Cultural Diversity in ... We find that the EU film market is highly fragmented and cross-border film availability in cinema is low. We explore different ...
Cross Talk Pathways Between Coagulation and Inflammation. Jonathan H. Foley, Edward M. Conway ... Your Name) thought you would like to see the Circulation Research web site. ... Thank you for your interest in spreading the word on Circulation Research. ...
COX-2, Another Important Player in the Nitric Oxide-Endothelin Cross-Talk. Good News for COX-2 Inhibitors?. Ulrich Hink, Thomas ... In this issue of Circulation Research, Zhou et al15 examined to what extent chronic NO deficiency may alter ETA mediated ... Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2. Circulation. 2004; 110: ... Your Name) thought you would like to see the Circulation Research web site. ...
The second cross-seasonal influence is the lagged response of MAM circulation and precipitation to DJF SAM-related SST. That is ... Theoretically, the cross-seasonal influence of the DJF SAM on MAM meridional circulation and precipitation may act in three ... 2 and 4 verifies the potential role of the SOD in the cross-seasonal linkage between the DJF SAM and MAM meridional circulation ... Cross-Seasonal Influence of the December-February Southern Hemisphere Annular Mode on March-May Meridional Circulation and ...
3 shows a cross sectional view of the pipe steamer 20 for use in the steam circulation apparatus and system 1 of FIG. 1. FIG. 4 ... 3 shows a side view or cross sectional view of a pipe steamer for use in the steam circulation apparatus and system of FIG. 1; ... The steam circulation apparatus and system 1 includes steam application stations 2, 4, 6, 8, 10, 12, 14, and 16, pipe steamers ... In the steam circulation apparatus and system 1 of FIG. 1 power reinforcers (of 30, 32, 34, and 36) are installed on two sides ...
A handling method for a natural circulation boiling water reactor having a chimney having cylindrical chimney shell disposed ... 2c shows a cross-section taken along a line Y-Y in FIG. 2a. However, in FIGS. 2a-2c the chimney shell is omitted for the sake ... After outlines of the natural circulation boiling water reactor are described, the chimney included in the natural circulation ... 8b, the flow path partition walls 211b form grids in the cross sectional view and the flow paths 211a form a square shape. The ...
... but the complexity of circulation in those seasons needs to be resolved to confirm the strength of this connection. Our results ... strongly suggest cross-boundary coordination is essential in the conservation of deep-water corals in the northwest Atlantic, ... Regional Ocean Circulation. Ocean circulation at the shelf edge of the Gulf of Maine is influenced in part by regional ... circulation is dominated by strong M2 tidal currents (semidiurnal) coupled with an anticyclonic residual circulation with ...
Public faith in the Swedish Red Cross (Röda Korset) has taken a beating in the wake of the embezzlement scandal involving its ... Malmö police: surge in number of fake notes in circulation. Swedish bank Nordea accused of money laundering after Danske Bank ... Public faith in the Swedish Red Cross (Röda Korset) has taken a beating in the wake of the embezzlement scandal involving its ... Only 19 percent of those surveyed expressed a very positive view of the Red Cross in the survey, down from 42 percent in March ...
11/15/2018 Blood, Heart and Circulation A protein central to immune system function is a new target for treating pulmonary ... However, the study found no association between the years of training in cross-country skiing (an average of 36 years in this ... 1. Grimsmo J, Grundvold I, Maehlum S, Arnesen H. High prevalence of atrial fibrillation in long-term endurance cross-country ... A high prevalence of atrial fibrillation found among highly trained cross-country skiers taking part in Norways annual ...
Circulation. 2017;135:e146-603. https://doi.org/10.1161/cir.0000000000000485.CrossRefPubMedPubMedCentralGoogle Scholar ... Fifty-four healthy, non-smoking men and women aged 18-50 years were included in this cross-sectional sub-study of a randomized ... Although no causal relationship can be made due to the cross-sectional design of the study, the current study shows that the ... Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort ...
In this cross-sectional study we took advantage of the natural experimental conditions resulting from the variable fasting ... The major limitation of our research was that all analyses were conducted across a large sample and on a cross-sectional basis ... Fasting Might Not Be Necessary Before Lipid Screening: A Nationally Representative Cross-sectional Study. Michael J. Steiner, ... Comparing a nationally representative cross-section of children who had fasted for various lengths of time, we demonstrated ...
... using a repeat cross sectional design before and after implementation of the legislation. This survey is a cross sectional in- ... Circulation 2006;114:1490-6.. OpenUrlAbstract/FREE Full Text. *↵. Smoking Health and Social Care (Scotland) Act 2005, Part 1. ... Our repeat cross sectional design is less robust than a longitudinal design. However, loss to follow-up in longitudinal surveys ... nationally representative cross sectional survey-Scottish changes in child exposure to environmental tobacco smoke (CHETS) ...
Design: Cross sectional study using multivariate regression models to examine the relation between clinical variables and left ... Cross sectional study of contribution of clinical assessment and simple cardiac investigations to diagnosis of left ventricular ... This study is a substudy of a cross-sectional survey that aimed to determine the prevalence of heart failure in general ... Suspected cases were identified within the cross sectional study population by reviewing all general practice case notes and ...
"Circulation. 116: 443. Archived from the original on 15 October 2015.. *^ Loria V, Dato I, Graziani F, Biasucci LM (2008). " ... "Southern Cross Healthcare Group. Archived from the original on 3 March 2014. Retrieved 15 September 2013.. ... "Circulation. 102 (10): 1082-85. doi:10.1161/01.CIR.102.10.1082. PMID 10973834. Archived from the original on 5 July 2011.. ... "Circulation: Cardiovascular Quality and Outcomes. 9 (3): 257-264. doi:10.1161/CIRCOUTCOMES.115.002224. PMC 4940126 . PMID ...
Anatomy Visible in the Medical Illustration Includes: Child, fetal circulation, foetal, foetus, lungs, heart. Image created by ...
American Red Cross. First Aid/CPR/AED Participants Manual. 2nd ed. Dallas, TX: American Red Cross; 2016. ... Circulation. 2015;132(18 Suppl 2):S519-S525. PMID: 26472999 www.ncbi.nlm.nih.gov/pubmed/26472999. ... Circulation. 2015;132(18 Suppl 2):S414-S435. PMID: 26472993 www.ncbi.nlm.nih.gov/pubmed/26472993. ...
American Red Cross. First Aid/CPR/AED Participants Manual. 2nd ed. Dallas, TX: American Red Cross; 2016. ... Circulation. 2015;132(18 Suppl 2):S414-S435. PMID: 26472993 www.ncbi.nlm.nih.gov/pubmed/26472993. ...
Cross Circulation Succeeds August 18, 1951 by Science News * Feature Cortisone for Asthma ...
Green Cross Corp. Stable emulsion of fluorocarbon particles. US3894541 *. 27 Feb 1974. 15 Jul 1975. El Shafei Ismail Lotfy. ... and circulation monitoring means for insuring that desired circulation flows and pressures are maintained within the system. ... Zoll Circulation, Inc.. System and method for management of body temperature. US20040039431 *. 20 Aug 2003. 26 Feb 2004. ... The circulation route illustrated in FIG. 1 permits the treatment of at least cerebral tissues. It is within the scope of the ...
Circulation. 1998;97(13):1257-1263.. View this article via: PubMed Google Scholar ... Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. Pervinder Sagoo,1,2,3,4 ... ROC curve generation combining cross-platform biomarkers. ROC curves of the training set (A) and test set (B) generated using ... However, before these cross-platform biomarkers can be implemented as a decisional tool in the clinical setting, the findings ...
ETCs: likely poleward movement of circulation features but low confidence in intensity changes (AR5). TCs: SLR will lead to ... Cross-Chapter Box 9: Integrative Cross-Chapter Box on Low-Lying Islands and Coasts. In: IPCC Special Report on the Ocean and ... coping capacities and cross-scale social and economic impacts (Sections 4.4.3, 4.4.5, Cross-Chapter Box 3 in Chapter 1). As a ... Djalante, R. et al., 2018: Cross-Chapter Box 12: Residual risks, limits to adaptation and loss and damage. In: Global Warming ...
On-site bus circulation; buses cross each other • Requires acquisition and relocation of 3 properties (including gas station ... of Relocations = 1 Fast Auto Loans BUS ACCESS/CIRCULATION Proposed Intersection Improvements Improved Pedestrian Access On-site ... On-site Bus Circulation • Cost Effectiveness • Amenities • Bus Access • Traffic • Intermodality • Neighborhood Development • ... Efficient on-site bus circulation; loop design • High potential for future neighborhood development • Adjacent to busy ...
Retrospective cross-sectional analysis of the changes in marijuana use in the USA, 2005-2018. BMJ Open 2020;10: e037905. ... We performed a cross-sectional study using data collected from 2 cycles of the annual Behavioral Risk Factor Surveillance ... Recent cannabis use and myocardial infarction in young adults: a cross-sectional study. Karim S. Ladha, Nikhil Mistry, Duminda ... Methods: We performed a cross-sectional study using pooled data from the 2017 and 2018 cohorts of the American Behavioral Risk ...
  • The closure of the ductus arteriosus, ductus venosus, and foramen ovale completes the change of fetal circulation to newborn circulation. (ahealthyme.com)
  • SSRIs cross the placenta and enter the fetal circulation. (eurekalert.org)
  • Gadolinium can cross the placenta and enter the fetal circulation. (eurekalert.org)
  • Two cases are described in which the systemic and pulmonary blood streams cross at atrioventricular level. (ahajournals.org)
  • One of the greatest disadvantages of the Fontan circulation is that it does not have a subpulmonary ventricle to augment the pulmonary circulation. (springer.com)
  • 2016). This integrative Cross-Chapter Box focuses on the array of challenges created by the melting of the cryosphere and the changing ocean, described throughout the report, to address societal risks, adaptation and the future habitability of LLIC. (ipcc.ch)
  • RESEARCH DESIGN AND METHODS -We conducted cross-sectional and prospective analyses of diabetes status and lung function decline using baseline and 3-year follow-up data on 1,100 diabetic and 10,162 nondiabetic middle-aged adults from the Atherosclerosis Risk in Communities (ARIC) Study. (diabetesjournals.org)
  • Methods This international, observational, cross-sectional survey of patients with any history of AF in the previous year, recorded AF characteristics, management and frequency of control (defined as sinus rhythm or AF with resting heart rate ≤80 bpm). (bmj.com)
  • Evaluation of human coronary blood flow with an 80 channel 20 MHz pulsed Doppler velocimeter and zero-cross and Fourier transform methods during cardiac surgery. (biomedsearch.com)
  • Alaveras, Georgios and Gomez-Herrera, Estrella and Martens, Bertin, Cross-Border Circulation of Films and Cultural Diversity in the EU (November 1, 2018). (ssrn.com)
  • We performed a cross-sectional study using pooled data from the 2017 and 2018 cohorts of the American Behavioral Risk Factor Surveillance System survey of US adults. (cmaj.ca)
  • As shown in FIG. 8 b , the flow path partition walls 211 b form grids in the cross sectional view and the flow paths 211 a form a square shape. (freepatentsonline.com)
  • Design Repeat cross sectional survey. (bmj.com)
  • Cross sectional study using multivariate regression models to examine the relation between clinical variables and left ventricular systolic dysfunction as determined by echocardiography. (bmj.com)
  • This study is a substudy of a cross-sectional survey that aimed to determine the prevalence of heart failure in general practice. (bmj.com)
  • We performed a cross-sectional study using data collected from 2 cycles of the annual Behavioral Risk Factor Surveillance System (BRFSS), a health-related telephone survey conducted by the Centers for Disease Control and Prevention (CDC). (cmaj.ca)
  • Cross-sectional studies have consistently shown that adults with diabetes have lower vital capacity than their nondiabetic counterparts ( 1 - 5 , 7 ), but such studies cannot establish the temporal sequence of events. (diabetesjournals.org)
  • Hospital-based cross-sectional study at Cumhuriyet University, Sivas, Turkey. (scielo.br)
  • Design Data from two nationally-representative cross-sectional surveys undertaken in 2013-2014. (bmj.com)
  • international, cross-sectional. (bmj.com)
  • Design Population-based cross-sectional study. (bmj.com)
  • The cross-sectional design cannot realise an investigation of the causal pathway of the association between the ACE genotype and salt intake interaction with hypertension, although possible mechanisms were suggested for the interaction effect on hypertension. (bmj.com)
  • Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study. (francoangeli.it)
  • Background and Purpose -The cross-sectional and 4-year longitudinal associations between brachial pulse pressure (PP) and ultrasound measurements of common carotid intima-media thickness (CCA-IMT) were assessed. (ahajournals.org)
  • No association between mean blood pressure and CCA-IMT was observed once PP was taken into account, in either cross-sectional or longitudinal analyses (partial correlation coefficients ranged from 0.00 to 0.03). (ahajournals.org)
  • Several cross-sectional epidemiological studies have shown positive but moderate associations between brachial PP and ultrasound measurements of common carotid intima-media thickness (CCA-IMT), 5 6 7 8 an early marker of atherosclerosis and/or vascular remodeling. (ahajournals.org)
  • 8 9 10 However, cross-sectional results do not allow determination of the direction and time-dependent relationships. (ahajournals.org)
  • Longitudinal studies are thus necessary to confirm and extend the cross-sectional findings and indicate the possible direction of the relationships. (ahajournals.org)
  • A population based cross-sectional study was conducted among 3227 individuals in Gondar city. (biomedcentral.com)
  • consequently, data linking directly measured insulin resistance with CVD is derived mostly from cross-sectional studies ( 10 ) and rarely from prospective cohorts ( 11 , 12 ). (diabetesjournals.org)
  • The cross-sectional area of capillaries is much greater than that of any other vessel in the human body. (brainscape.com)
  • Velocity of blood flow is inversely proportional to vascular cross-sectional area. (brainscape.com)
  • Thus, the increased cross-sectional area of capillaries results in a small velocity, which in-turn slows down blood flow so that adequate exchange of nutrients and gases can occur. (brainscape.com)
  • B) Cross-sectional view of the wing profile. (biologists.org)
  • This cross-sectional study aimed to characterise the metabolic profile of breast cancer survivors relative to abdominal obesity and insulin resistance. (biomedcentral.com)
  • A national cross-sectional study based on stratified cluster random sampling was conducted in 2015. (who.int)
  • In a study published today on Nature Communications ' website, the researchers describe the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient for 36 to 56 hours. (news-medical.net)
  • A previous study from the team demonstrated a cross-circulation platform that maintained the viability and function of a donor lung for 36 hours. (news-medical.net)
  • The aim of this study was to determine whether anti-CagA antibodies cross-react with antigens of normal and atherosclerotic arteries. (ahajournals.org)
  • However, the study found no association between the years of training in cross-country skiing (an average of 36 years in this study) and the occurrence of AF. (healthcanal.com)
  • OBJECTIVE -The aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally. (diabetesjournals.org)
  • In our pilot study patients with partial anterior circulation type TIAs had significantly reduced ADAMTS-13 activity compared to controls (p=0.0394). (bmj.com)
  • Waste products and carbon dioxide from the fetus are sent back through the umbilical cord and placenta to the mother's circulation to be removed. (ahealthyme.com)
  • 20 . The method of claim 17 wherein oxygenated blood flow to venous circulation results in an increase of oxygen content in the blood entering the lungs of the patient. (google.es)
  • SIBO is associated with hyperdynamic circulation and other hemodynamic changes in cirrhosis and may be a principal factor causing these through systemic inflammation. (nih.gov)
  • The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. (exposed-skin-care.net)
  • 19 . The method of claim 17 wherein oxygenated blood flow to venous circulation results in a decrease in systemic vascular resistance of the patient. (google.es)
  • What properties of arteries maintain the pressure in systemic circulation? (brainscape.com)
  • 84% of blood volume is in the systemic circulation. (brainscape.com)
  • What percentage of blood in the systemic circulation is found in the systemic arterioles and capillaries? (brainscape.com)
  • Staywell®´´, an independent company, offers health and wellness engagement tools and information on behalf of Blue Cross Blue Shield of Massachusetts. (ahealthyme.com)
  • Blue Cross Blue Shield of Massachusetts is a leading provider of quality health insurance for residents of Massachusetts. (ahealthyme.com)
  • This is the third edition of "Blue Cross Blue Shield, The Health of America Report," a collaboration between the Blue Cross Blue Shield Association and Blue Health Intelligence, which uses a market-leading claims database to uncover key trends and insights into healthcare affordability and access to care. (bcbs.com)
  • Atmospheric general circulation model simulations further verify that MAM meridional circulation between the SH middle latitudes and the northern subtropics responds to the MAM SOD. (ametsoc.org)
  • New evidence suggests that interannual variability in zonal-mean meridional circulation and precipitation can be partially attributed to the Southern Hemisphere annular mode (SAM), the dominant mode of climate variability in the Southern Hemisphere (SH) extratropics. (ametsoc.org)
  • A cross-seasonal correlation exists between the December-February (DJF) SAM and March-May (MAM) zonal-mean meridional circulation and precipitation. (ametsoc.org)
  • The DJF SOD can persist until the following MAM when it begins to modulate MAM meridional circulation and large-scale precipitation. (ametsoc.org)
  • To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults. (nih.gov)
  • Flow energy loss (EL) at the Fontan anastomosis has been thought to reflect flow efficiencies and to influence on hemodynamics in the Fontan circulation and has been often discussed in numerical studies. (springer.com)
  • We directly measured EL in the Fontan circulation and examined the relationship between the structural configuration and EL, as well as the influence of EL, on the hemodynamics in the Fontan circulation. (springer.com)
  • therefore, it is essential to clarify the hemodynamics in the Fontan circulation. (springer.com)
  • Our results strongly suggest that cross-boundary coordination is essential in the conservation of aggregations of deep-water corals in the northwest Atlantic, by ensuring larval exchange and connectivity. (frontiersin.org)
  • Results offer the most comprehensive cross-national demonstration of negativity biases to date, but they also serve to highlight considerable individual-level variation in responsiveness to news content. (pnas.org)
  • Paradoxically, CD3 cross-linking prior to TCR stimulation results in apoptotic cell death, as does injection of anti-CD4 antibodies in vivo of CD4 ligation by HIV glycoprotein (gp) 120. (pnas.org)
  • We have found that CD4 cross-linking results in a small but rapid increase in levels of cell surface Fas, a member of the tumor necrosis factor receptor family implicated in apoptotic death and maintenance of immune homeostasis. (pnas.org)
  • CONCLUSIONS These results identify a novel antagonistic cross-talk between IFN-γ and Hh signaling in white adipose tissue and demonstrate IFN-γ as a potent inhibitor of Hh signaling. (diabetesjournals.org)
  • Their results are published in the September 30, 2008 issue of Circulation . (medscape.com)
  • In light of recent findings in neurons that IFN-γ and Hh signaling cross-talk, we examined their potential interaction in the context of adipogenesis. (diabetesjournals.org)
  • A method and drilling fluid additive composition are provided for reducing lost circulation and seepage loss when synthetic or oil based drilling fluid is used. (google.com)
  • 6 . A lost circulation drilling fluid additive for use with synthetic or oil based drilling fluids comprising 20 to 80 parts by weight fibrous particles, 10 to 40 parts by weight lignite, and 10 to 40 parts by weight phenol-formaldehyde resin solids. (google.com)
  • found that thrombospondin-1 (TSP1) bound to and inhibited the processing of the precursor form of the collagen cross-linking enzyme lysyl oxidase. (sciencemag.org)
  • TSP1 also bound to collagen molecules intracellularly and at conserved cross-linking sites. (sciencemag.org)
  • In vitro, TSP1 bound to both the C-propeptide domain of collagen I and the highly conserved KGHR sequences of the collagen triple-helical domain that participate in cross-linking. (sciencemag.org)
  • Gait use was investigated via a combination of three-dimensional kinematics and quasi-steady aerodynamic modeling of bound circulation on the distal and proximal portions of the wing. (biologists.org)
  • This implies that a constant bound circulation is maintained over the airfoil (wing) throughout the entire wingbeat cycle and that lift is generated during both the upstroke and downstroke ( Fig. 1B ) ( Rayner, 1993 ). (biologists.org)
  • Several previous reports demonstrated that intra-arterial (IA) thrombolytic therapy or aspiration thrombectomy using the cross-circulation technique via an alternative collateral pathway is feasible in acute stroke patients with an unfavorable direct route to the occluded sites. (bvsalud.org)
  • Through adoptive cell transfers and cross-breeding to hypercholesterolemic mice expressing the antigenic human LDL protein apolipoprotein B-100, we evaluate the effects on atherosclerosis. (nih.gov)
  • Ex Vivo Heart Perfusion for 72 Hours Using Plasma Cross Circulation. (nih.gov)
  • In this report we investigate the mechanism by which CD4 cross-linking induces cell death. (pnas.org)
  • 14, 1980, entitled "Extravascular Circulation Oxygenated Synthetic Nutrients to Treat Tissue Hypoxic and Ischemic Disorders", now U.S. Pat. (google.co.uk)
  • Using PubMed and Medline, followed by cross-references, we identified 60 articles in which blood pressure data were available for populations that were judged as unacculturated or partially acculturated. (ahajournals.org)
  • You can search here for known cross-border obstacles between the Nordic countries. (norden.org)
  • We envision that interventional cross-circulation may be used to investigate regeneration of other damaged organs, such as hearts, kidneys, and livers, expanding donor pools by salvaging severely damaged organs and leading to more organ transplants,' Bacchetta adds. (news-medical.net)
  • In an attempt to shed light on Zika circulation, scientists from the Institut Pasteur and the CNRS, in collaboration with US teams and the Thai National Institute of Health, decided to investigate the history of the Zika virus in Thailand. (pasteur.fr)
  • A framework is built to explain the cross-seasonal impact of SAM-related SST anomalies. (ametsoc.org)
  • To explore the potential impact of these differences in healthcare, this report analyzed medical claims from Blue Cross and Blue Shield (BCBS) members to compare heart attack rates and treatment patterns between women and men in the United States. (bcbs.com)
  • Unions may organize a particular section of skilled workers ( craft unionism ), [3] a cross-section of workers from various trades ( general unionism ), or attempt to organize all workers within a particular industry ( industrial unionism ). (wikipedia.org)
  • Compared to skin from wild-type mice, skin from Thbs1 −/− mice had reduced collagen cross-linking and reduced prolysyl oxidase (proLOX) abundance with increased conversion to catalytically active LOX. (sciencemag.org)
  • Only 19 percent of those surveyed expressed a very positive view of the Red Cross in the survey, down from 42 percent in March. (thelocal.se)