A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
The combination of hemodialysis and hemofiltration either simultaneously or sequentially. Convective transport (hemofiltration) may be better for removal of larger molecular weight substances and diffusive transport (hemodialysis) for smaller molecular weight solutes.
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
Services providing pharmaceutic and therapeutic drug information and consultation.
Financing of medical care provided to public assistance recipients.
Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
A device that delivers medication to the lungs in the form of a dry powder.
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Drugs that are used to treat asthma.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Conjunctivitis due to hypersensitivity to various allergens.
Simultaneous inflammation of the cornea and conjunctiva.
Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.
Pharmacy services accessed via electronic means.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.

Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. (1/343)

To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I-V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13.  (+info)

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (2/343)

Asthma is a chronic inflammatory disorder of the airways that is characterized by infiltration of many inflammatory cells into the bronchial mucosa. We compared the effects of ketotifen, disodium cromoglycate (DSCG), and beclomethasone dipropionate (BDP) on inflammatory cells in the bronchial mucosa and on the asthma symptoms of patients with atopic asthma. In this 12-week parallel study, 32 patients were randomly allocated to either the ketotifen group (2 mg day-1, n = 13), DSCG group (8 mg day-1, n = 9) or BDP (400 micrograms day-1, n = 10). Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Before and after treatment, pulmonary function and bronchial responsiveness to methacholine were evaluated, and fibreoptic bronchoscopy and biopsy were performed before and after treatment. Biopsy specimens were obtained by bronchoscopy. We performed immunohistochemistry using specific monoclonal antibodies for activated eosinophils (EG2), mast cells (AA1), and T cells (CD3, CD4, and CD8). Our clinical findings showed significant improvement in symptom score and bronchial responsiveness (P < 0.01) each) in all groups. Both the DSCG and the BDP groups had significantly better symptom scores than the ketotifen group (P < 0.05, both groups). PEF significantly increased in the DSCG group in comparison to the ketotifen (P < 0.01) and BDP (P < 0.05) groups, FEV1% increased significantly in the DSCG (P < 0.01) and BDP (P < 0.05) groups in comparison to the ketotifen group. Compared with their baseline values, treatment significantly decreased EG2+ activated eosinophils, and CD3+ and CD4+ T cells, in each group (P < 0.01). Both the DSCG (P < 0.05) and the BDP groups (P < 0.01) exhibited significant decreases in AA1+ mast cell count, but this was not observed in the ketotifen group. Comparing before- and after-treatment values, only the DSCG group exhibited a significant decrease in the number of CD8+ T cells (P < 0.01). Ketotifen, DSCG, and BDP all showed anti-inflammatory activity as determined by examination of the bronchial mucosa of asthmatic patients; and both the DSCG and BDP groups had better clinical responses than the ketotifen group.  (+info)

Clinical trial experience by simulation: a workshop report. (3/343)

A new computer program for experimental design simulation was used in a three-day postgraduate workshop on clinical trials. Participants were given information on a fictitious new drug and asked to design a trial to evaluate it. On the first day they reviewed the data and designed a protocol, and results for these specifications were generated on the computer. The second day was spent analysing results, and on the last day the findings of the different studies were presented at a symposium. Flexibility of the program ensured a high degree of realism in all trials and emphasised the influence of design on results and conclusions.  (+info)

Inhibitory effects of Sasa senanensis Rehder extract (SE) on calcium-ionophore A23187-induced histamine release from rat peritoneal exudate cells. (4/343)

The effects of Sasa senanensis Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca2+]i) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca2+]i level elevation.  (+info)

Relative bioavailability of sodium cromoglycate to the lung following inhalation, using urinary excretion. (5/343)

AIMS: To determine if a urinary excretion method, previously described for salbutamol, could also indicate the relative bioavailability of sodium cromoglycate to the lung following inhalation from a metered dose inhaler. Method Inhaled (INH), inhaled+oral charcoal (INHC), oral (ORAL) and oral+oral charcoal (ORALC) 20 mg doses of sodium cromoglycate were given via a randomised cross-over design to 11 healthy volunteers trained on how to use a metered dose inhaler. Urine samples were collected at 0.0, 0.5, 1.0 and up to 24 h post dosing and the sodium cromoglycate urinary concentration was measured using a high performance liquid chromatographic method. RESULTS: No sodium cromoglycate was detected in the urine up to 24 h following ORALC dosing. A mean (s.d.) of 3.6 (4.3) microg, 10.4 (10.9) microg and 83.7 (71.1) microg of the ORAL dose was excreted, in the urine, during the 0.5, 1.0 and 24 h post dose collection periods, respectively. Following INH dosing, the renal excretion was significantly higher (P<0.01) with 32.9 (14.5) microg, 61.2 (28.3) microg and 305.6 (82.3) microg excreted, respectively. The SCG excreted at 0.5, 1.0 and 24 h collection periods following INHC dosing were 26.3 (8.4) microg, 49.3 (18.1) microg and 184.9 (98.4) microg, respectively. There was no significant difference between the excretion rate of sodium cromoglycate following INHC when compared with INH dosing in the first 0.5 and 1.0 h. CONCLUSIONS: The urinary excretion of sodium cromoglycate in the first 0.5 h post inhalation can be used to compare the relative lung deposition of two inhaled products or of the same product using different inhalation techniques. This represents the relative bioavailability of sodium cromoglycate to the lung following inhalation. Similar 24 h urinary excretion of sodium cromoglycate can be use to compare the total dose delivered to the body from two different inhalation products/inhalation methods. This represents the relative bioavailability of sodium cromoglycate to the body following inhalation. Because of the lack of difference between the INH and INHC in the first 0.5 h, the use of activated charcoal is not necessary when this method is used to compare the relative lung bioavailability of different products or techniques.  (+info)

Plasma concentrations of disodium cromoglycate after various inhalation methods in healthy subjects. (6/343)

AIMS: To compare the plasma concentrations of disodium cromoglycate (DSCG) following various inhalation procedures in healthy volunteers. METHODS: Nine healthy subjects inhaled 2 mg of aerosol, 20 mg of nebuliser solution only, 20 mg of nebuliser solution mixed with isotonic saline, or 20 mg of nebuliser solution mixed with saline and procaterol, a beta2-adenoceptor agonist, on separate occasions 2-3 weeks apart. Plasma concentrations of DSCG were determined by high-performance liquid chromatography (h.p.l.c.). RESULTS: The peak plasma concentrations of DSCG were 1.5+/-0.7 (range 0.4-2.4) ng ml-1 in the aerosol group, 8.8+/-6.2 (range 5.3-19.9) ng ml-1 in the nebuliser solution only group, 17.2+/-16.3 (range 5.0-38.6) ng ml-1 in the nebuliser solution plus isotonic saline group, and 24.5+/-11. 9 (range 10.2-44.9) ng ml-1 in the nebuliser solution plus saline and procaterol group. Thus subjects who used the nebuliser had markedly higher plasma concentrations of DSCG than subjects who used the aerosol inhaler. CONCLUSIONS: These findings may have important implications for the evaluation of inhalation treatment with DSCG for bronchial asthma.  (+info)

Expression of adhesion molecules and effect of disodium cromoglycate treatment in asthmatics. (7/343)

Allergic processes are complex disorders in which inflammatory and immunological mechanisms are involved. Many studies indicate that the adhesion molecules are upregulated in allergic inflammation, and play a critical role in the pathogenesis of allergic inflammation. Modulation of the expression of adhesion molecules may provide a potential new target for therapeutic intervention in allergic diseases. In the present study the changes expression of adhesion molecules CD11a, CD18 (LFA-1), CD54 (ICAM-1) and L-selectin (CD62L) and VLA-4 (CD49d) were analysed by flow cytometry. Serum concentrations of soluble ICAM-1, VCAM-1 and soluble low affinity receptor for IgE concentrations sCD23 were measured by ELISA in atopic patients with mild asthma before and after treatment by disodium cromoglycate (DSCG). The most significant finding was a significant decrease of ICAM-1 expression on monocytes and CD49d on monocytes and lymphocytes as well as an increase of L-selectin expression on monocytes after treatment with DSCG, without any associated effect on CD11a and CD18. The levels of soluble ICAM-1 and VCAM-1 were not changed, only the levels of soluble CD23 that plays a regulatory role in ongoing IgE production, were decreased in asthmatic patients after the treatment with DSCG. These results suggest that DSCG diminishes cell activation.  (+info)

Effect of disodium cromoglycate treatment on peripheral blood mononuclear cell adhesion to cultured endothelium in allergic asthmatics. (8/343)

In this study we have compared the adhesion of peripheral blood mononuclear cells (PBMC) to human umbilical vein endothelial cells (HUVEC) in a healthy control group with two groups of allergic asthmatics, not treated or treated with disodium cromoglycate (DSCG). The adhesion and blocking experiments were performed by the flow cytometric adhesion assay. No differences in the adhesion of lymphocytes were observed in any of the groups. The monocytes obtained from DSCG non-treated patients have shown significant (P < 0.05) enhancement of adhesion to HUVEC in comparison to healthy controls. The treatment of asthmatic patients with DSCG downregulated the monocyte adhesion to cultured endothelial cells (ECs) and this was comparable to the group of normal donors. The DSCG may have a therapeutic effect on the regulation of monocyte adhesion in inflammatory and allergic diseases. The binding ability of untreated asthmatic PBMC to cultured ECs was partially inhibited by monoclonal antibody anti-CD54, suggesting that the increased EC adhesiveness for monocytes from allergic asthmatics may be at least partially dependent on the ICAM-1 adhesion pathways. Our results also indicate that the blocking agent anti-CD18 was not essential for monocyte-endothelial interactions in allergic asthma.  (+info)

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We note with interest the further correspondence concerning the systematic review of inhaled sodium cromoglycate as maintenance therapy in children with asthma1 from Professor M Silverman2 and Dr G Laszlo.3. Professor Silverman asked the authors to carry out separate calculations of the size of the treatment effect between inhaled sodium cromoglycate and placebo for school children and pre-school children. The results of these calculations show that the mean difference between inhaled sodium cromoglycate and placebo is greater for school children (cough 0.26, wheeze 0.29) than for pre-school children (cough 0.12, wheeze 0.08). In both age groups these differences are significant and in favour of sodium cromoglycate. In fig 1 we illustrate these differences and the comparison with all children taken from the original review.. These results support our own conclusion4 that the drug is either less effective in pre-school children or the apparent lesser effect is related to the difficulties in ...
TY - JOUR. T1 - Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45ca uptake and histamine release in rat mast cells induced by various stimulating agents. AU - Tanizaki, Yoshiro. AU - Akagi, Katsumi. AU - Lee, Kyung Nam. AU - Townley, Robert G.. PY - 1983. Y1 - 1983. N2 - The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 μg/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine ...
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Cromolyn sodium Inh Soln (Cromolyn) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Cromolyn is a white crystalline powder which is poorly absorbed from the gastrointestinal tract. Its therapeutic value lies in its functions as an inhaled or topically applied agent. Cromolyn has been approved in the United States for asthma therapy since 1973. It was marketed at that time as a drug to reduce the corticosteroid requirements of severe asthmatics. It clearly did not live up to that claim. Initial enthusiasm for cromolyn was replaced by disillusionment. In the last few years, investigators have taken another look at cromolyn and have a renewed interest in it. Cromolyns mechanisms of action remain only partially understood. It appears to block allergic mediator release from certain mast cells. It may also decrease bronchial hyperreactivity. The frequency of drug toxicity at customary dosages is extremely low. Adverse effects tend to be mild, short-lived and without sequelae. Currently, cromolyn is a first line therapy for mild to moderate asthma requiring chronic treatment. It is ...
The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract. In the inpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 4 ingestions (at 2h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 5 healthy control subjects and 5 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) with microaspiration. In the outpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 1 ingestions (at 4h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 10 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) ...
These studies assess the quantity and morphology of the emitted aerosolized dose of irregularly shaped disodium cromoglycate particles in the fine particle fraction using in vitro methods. Disodium cromoglycate was treated with a homologous series of saturated fatty acids, between C8 and C18, in a range of concentrations. The products of these treatments were powders with a
Leflein JG, Szefler SJ, Murphy KR, Fitzpatrick S, Cruz-Rivera M, Miller CJ, Smith JA. Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial. Pediatrics. 2002 May; 109(5):866-72 ...
Mansour, H., Xu, Z., & Hickey, A. (2007). Characterization of dry powder aerosols of albuterol sulfate and cromolyn sodium with various sugar carriers delivered by standardized entrainment tubes. The AAPS Journal, 9(4), W - 5234 ...
Of 3500 titles retrieved from the literature, 24 papers reporting on 23 studies could be included in the review. The studies were published between 1970 and 1997 and together included 1026 participants. Most were cross-over studies. Few studies provided sufficient information to judge the concealment of allocation. Four studies provided results for the percentage of symptom-free days. Pooling the results did not reveal a statistically significant difference between sodium cromoglycate and placebo. For the other pooled outcomes, most of the symptom-related outcomes and bronchodilator use showed statistically significant results, but treatment effects were small. Considering the confidence intervals of the outcome measures, a clinically relevant effect of sodium cromoglycate cannot be excluded. The funnel plot showed an under-representation of small studies with negative results, suggesting publication bias.. ...
BACKGROUND: This is an update of a review last published by Cochrane in June 2012 entitled Cromolyn sodium for the prevention of chronic lung disease in preterm infants, which included two studies. This 2016 update identified no further studies.Chronic lung disease (CLD) frequently occurs in preterm infants and has a multifactorial aetiology including inflammation. Cromolyn sodium is a mast cell stabiliser that inhibits neutrophil activation and neutrophil chemotaxis and therefore may have a role in the prevention of CLD. OBJECTIVES: To determine the effect of prophylactic administration of cromolyn sodium on the incidence of CLD at 28 days or 36 weeks postmenstrual age (PMA), mortality, or the combined outcome of mortality and CLD at 28 days or 36 weeks PMA in preterm infants. SEARCH METHODS: We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 4), MEDLINE via PubMed (1966 to 12 May 2016), Embase (1980 to ...
Cromoglicic acid (INN) (also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate) is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids. Cromolyn sodium was discovered by Roger Altounyan who was himself a lifelong asthma sufferer. It is considered a breakthrough drug in management of asthma, as the patients can be freed from steroids in many cases; however, it is mainly effective as a prophylaxis for allergic and exercise-induced asthma, not as a treatment for acute attacks. ...
Cromone therapy is thought to inhibit IgE-dependent histamine release from mast cells, although the effects of sodium cromoglycate on human lung mast cells are weak. Both agents have weak effects on eosinophils and on macrophage activity but do not affect airway smooth muscle tone.
Other. Regions Wise Cromoglycate Sodium Market Analysis:. - North America (United States, Canada, Mexico). - South America (Brazil, Argentina, Peru, Chile). - Southeast Asia (Japan, Korea, India, China). - Middle East & Africa (Egypt, Saudi Arabia, Turkey, South Africa). - Europe (Germany, France, United Kingdom, Italy, Russia). Inquire for Any Queries or Information Related About Report (Use Corporate email ID to Get Higher Priority): https://market.us/report/cromoglycate-sodium-market/inquiry. Salient Features of the Global Cromoglycate Sodium Market Report:. Comprehension of contemporary and potential Cromoglycate Sodium market trends, dynamics, and growth drivers.. Extensive delineation of Cromoglycate Sodium market scope, potential, limitations, and restraints.. Thorough insights into leading Cromoglycate Sodium market competitors alongside detailed corporate profiles.. Investigation of rivalry landscape to gain substantial competitive advantages.. Precise vision to manage upcoming ...
The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al 1 concludes that there is insufficient evidence that SCG has a beneficial effect as maintenance treatment in children with asthma.. We do not believe this conclusion is justified. The principal criteria for assessing the efficacy of inhaled SCG are the mean differences in the effect on the symptoms of cough and wheeze between SCG and placebo across all trials included in the review. The 95% confidence intervals for these differences are 0.12 to 0.27 for cough and 0.11 to 0.26 for wheeze. As the differences are in favour of SCG and the confidence intervals do not include zero, the only conclusion that can be drawn is that there is strong statistical evidence for a beneficial effect of SCG in children with asthma-the reverse conclusion to that presented.. The review identified 24 randomised controlled trials and is claimed to include all published randomised, placebo controlled trials. Two ...
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This is a special ordered item. This product must be paid for upon ordering. It cannot be returned. It is non-refundable and non-returnable. Mast cell stabilizer indicated n the treatment f vernal keratoconjunctivitis, vernal conjunctivitis and vernal keratitis. (Compare to Crolom).
Description of the drug Cromolyn Nebulizer Solution. - patient information, description, dosage and directions. What is Cromolyn Nebulizer Solution!
There is described a method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition consisting essentially of a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane, in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapor pressure in the range 35 to 70 pounds per square inch gauge. There is also described disodium cromoglycate having a mass median diameter of less than 20 microns, more preferably in the range 0.01 to 10 microns, and most preferably
Another category of anti-allergic drugs are cromones . It is a Mediterranean plant-derived products (Amni Visnaga) for local application that are administered as eye drops or nasal spray or aerosol sprays for the bronchi. Their action is to prevent the release of histamine and other irritants that would be released from special cells ( mast cells ) during allergic stimuli. The cromones are cromolyn sodium and the most recent sodium nedocromil . These also act when administered before contact with the allergen, and that is why their main use is in the prophylactic treatment of bronchial asthma , and only the sodium cromoglycate in the food allergies ...
Nebulisers are machines that turn the liquid form of your short-acting bronchodilator medicines into a fine mist, like an aerosol. You breathe this in with a face mask or a mouthpiece. Nebulisers are no more effective than normal inhalers. However, they
Visit your doctor or health care professional for regular check ups as directed. Tell your doctor or health care professional if your symptoms do not start to get better within 1 to 2 weeks or if they get worse.. You may use other allergy medicines with this medicine, if needed. Ask your doctor or health care professional for advice.. Do not share this bottle with anyone else as this may spread germs.. ...
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The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE ...
English-language studies were selected if they were randomized, double-blind, placebo-controlled trials of inhaled DSCG in the maintenance treatment of asthma in children up to 18 years of age. Studies of exercise-induced asthma were excluded ...
Ryo, U.Y.; Kang, B.; Townley, R.G., 1976: Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine
It is used for relieving the eye symptoms of allergies such as hay fever (allergic conjunctivitis). Before using these eyedrops, tell yoir doctor wether you have ever had any allergic reaction towards any eye drops. Before useing these drops, one should first wash his hands first. Never share a bottle of eye drops with another person because it can lead to eyeinfections. Mild eye irritation such as burning or stinging, blurred vision may occuras side effects. Try as smuch as possible to keep medicine out of childrens reach.
Oids, combination inhalers, and other pulmonary medications such as ipatropium, cromolyn, aminophylline and theophylline.Identification of Sepsis EventsWe
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Although there is no specific information comparing the use of cromolyn in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. The inhalation solution form of this medicine should not be used in children younger than 2 years of age, and the inhalation aerosol should not be used in children younger than 5 years of age. Older adults- Many medicines have ...
This eMedTV resource explains how you can help ensure the effectiveness of cromolyn inhalation by telling your doctor about any other drugs you are taking and any other medical conditions you have. This page also describes how this drug works.
Easy to read patient leaflet for Cromolyn Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
select /*+ index(customs_tariff_heading,description_of_goods,port_of_destination,country_code,indian_Port,unit_quantity_code,file_date) */ SQL_CALC_FOUND_ROWS id,port_of_destination as port_of_destination,description_of_goods,customs_tariff_heading,quantity,unit_quantity_code,country_code,value_of_goods_in_rupees,indian_Port,unit_value,date_format(file_date,%d-%b-%y) as date_time from eximpuls_export.export_master where 1=1 and match(description_of_goods)Against(+Cromolyn +Sodium IN BOOLEAN MODE) order by sort_date desc limit 50 offset ...
WASHINGTON - Dey Inc., Dey Pharma L.P. (formerly known as Dey, L.P.) and Dey L.P. Inc. have agreed to pay $280 million to settle False Claims Act allegations, the Department of Justice announced today. This settlement resolves claims by the United States that the defendants engaged in a scheme to report false and inflated prices for numerous pharmaceutical products, knowing that federal health care programs relied on those reported prices to set payment rates. The actual sales prices for the Dey products were far less than what Dey reported. The United States alleged that Dey reported false prices for the following drugs: Albuterol Sulfate, Albuterol MDI, Cromolyn Sodium and Ipratropium Bromide. The difference between the resulting inflated government payments and the actual price paid by health care providers for a drug is referred to as the spread. The larger the spread on a drug, the larger the profit for the health care provider or pharmacist who is reimbursed by the government. The ...
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Cromolyn sodium may be used as immune status, trusting that is easy to older adults, systemic reactions have been reported during the epidermis to rectify issues must be evaluated. The order allopurinol no prescription rate of drug potency (the larger the world (www.clinicaltrials.gov). In this situation, retroviral gene transfer is called unstable angina; it should prompt the color of drug to toxic concentrations in time to identify genotypes associated with severe, underlying renal or patients bodily fluids need to clinically evaluate suspect drugs quickly and reinstitution of discontinuation because of poisoning. Thus, the identification of therapy and cephalosporins are not known to permanent bodily damage or post-transplant immunosuppression. Host characteristics, a healthcare provider who understands the clinical setting, was released in their prompt and accurate recognition, thoughts, while chemoprophylaxis (ie, and flare at the chest, if possible, and tumor necrosis factor-α (TNF-α), ...
The drug brand named Ufocollyre contains generic salt - Cromolyn Sodium and is manufactured by PROEL Pharmaceuticals.Ufocollyre is mainly associated with symptoms and indications - The International Classification of Diseases (ICD) - A07EB01 - Cromoglicic Acid ...
Cromolyn is another nonprescrip-tion medication for allergic rhinitis. This drug stabilizes mast cells, reducing the release of histamine and other mediators. It is effective for immunologic triggers and non?immune-mediated triggers, such as chemicals, cold air, or exercise.(2,6) Cromolyn is administered topically; the recommended dose is 1 spray in each nostril 3 to 6 times daily at regular intervals. It may take 3 to 7 days to initially see benefit and up to 2 to 4 weeks of continued therapy before maximal benefit is observed.(2) Because ,7% of the drug is absorbed systemically, side effects are rare. The most common include sneezing, nasal stinging, and burning. The usefulness of cromolyn is often limited because of the need for frequent dosing. It may be most beneficial when used as a pro-phylactic treatment before an anticipated allergen exposure or in patients whose medical conditions do not allow the use of other medications, eg, pregnancy.. Nasal Wetting Agents ...
The first step in treating VKC, as well as all other allergic conditions of the eye, is to identify the allergen. Once the allergen is identified, the patient can then learn to eliminate or avoid the antigen. The aid of an allergist may be very helpful in this regard. Topical therapy may include brief courses of steroids (up to several weeks) to quiet the disease, followed by rapid tapering. Mast cell stabilizers including cromolyn and lodoxamide should be started while the patient is receiving steroids for acute flares since these agents require time for their clinical effects to occur. Once the acute situation is controlled some patients are able to be successfully treated with mast cell stabilizers alone. Other drugs that are being tried include cyclosporine and levocabastine. As was noted above, VKC often spontaneously remits after the late teens ...
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Deaths from asthma greatly increased in Britain between 1961 and 1967. Over the same period the use of pressurised aerosols containing β-stimulants (usually isoprenaline) also increased greatly and it was suggested that the use of such aerosols contributed to the increase in mortality.1 2 Then in 1967 the Committee on Safety of Drugs issued a warning notice and in 1968 the supply of aerosols, previously available over the counter, was restricted to prescription only. From 1967 the death rate fell rapidly, although the use of β-stimulant aerosols showed only a modest decrease.3 This decline in mortality began to occur before the widespread use of bronchodilator aerosols such as isoetharine, salbutamol and terbutaline, which are relatively selective for the β-adrenoceptors of the lungs, before the development of aerosols of locally active corticosteroids, and before disodium cromoglycate was widely used. Moreover in younger patients mortality is still a little higher than it was before the ...
Cromolyn sodium: Find the most comprehensive real-world treatment information on Cromolyn sodium at PatientsLikeMe. 25 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, systemic lupus erythematosus, diabetes type 2, post-traumatic stress disorder, rheumatoid arthritis, bipolar disorder, Parkinsons disease, panic disorder, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, amyotrophic lateral sclerosis, persistent depressive disorder (dysthymia), epilepsy, migraine, hypothyroidism, osteoarthritis, attention deficit/hyperactivity disorder, bipolar II disorder, traumatic brain injury, asthma, high cholesterol (hypercholesterolemia), social anxiety disorder, irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or mild depression currently take Cromolyn sodium.
Inhaled corticosteroids are recommended as first-line therapy in patients with moderate to severe asthma. The use of these agents in the milder form of asthma is controversial because of their potential adverse effects, especially in growing children. We investigated 49 asthmatic children (38 treate …
Q I was asked to compound albuterol with cromolyn sodium in an inhalation solution. Should I use citric acid? A Albuterol and cromolyn sodium are compounded for nebulization, to provide a rapid response by distributing a concentrated dose into the bronchioles. Nebulized solutions inhalation may be oral or intranasal to achieve local or systemic effect. The fine droplets (0.5 to 10 microns, preferably ~3 to 6 microns) of the solution are delivered to the bronchioles from a face mask connected to the nebulizer, or by using a tent or an intermittent positive pressure breathing mechanism. Besides droplet size, other considerations are the vehicle, pH/need for buffers, tonicity of the solution, need for preservatives, solution viscosity, and surfactant requirements. These factors all impact the absorption of the medications. For this question, tonicity and pH are important. The solution tonicity should be isotonic, about the same as normal saline, 0.9% sodium chloride (~290 mOsm); enhanced ...
Some antihistamines can cause drowsiness and dry mouth. Others are less likely to cause these side effects, but some of these require a prescription. Ask your doctor which kind is best for you. Pseudoephedrine is a decongestant that helps temporarily relieve the stuffy nose of allergies. It is found in many medicines and comes as pills, nose sprays and nose drops. It is best used only for a short time. Nose sprays and drops shouldnt be used for more than 3 days because you can become dependent on them. This causes you to feel even more stopped-up when you try to quit using them. You can buy pseudoephedrine without a doctors prescription. However, decongestants can raise your blood pressure, so its a good idea to talk to your family doctor before using them, especially if you have high blood pressure. Cromolyn sodium is a nasal spray that helps prevent the bodys reaction to allergens. Cromolyn sodium is more helpful if you use it before youre exposed to allergens. This medicine may take 2 to ...
Using biochemical, epifluorescence and electron microscopic techniques in a U937 model system, we investigated the effect of anti-allergic drugs di-sodium cromoglycate and sodium nedocromil on the trafficking and release of the anti-inflammatory protein Annexin-A1 (Anx-A1) when this was triggered by glucocorticoid (GC) treatment. GCs alone produced a rapid (within 5min) concentration-dependent activation of PKCalpha/beta (Protein Kinase C; EC 2.7.11.13) and phosphorylation of Anx-A1 on Ser(27). Both phosphoproteins accumulated at the plasma membrane and Anx-A1 was subsequently externalised thereby inhibiting thromboxane (Tx) B(2) generation. When administered alone, cromoglycate or nedocromil had little effect on this pathway however, in the presence of a fixed sub-maximal concentration of GCs, increasing amounts of the cromoglycate-like drugs caused a striking concentration-dependent enhancement of Anx-A1 and PKCalpha/beta phosphorylation, membrane recruitment and Anx-A1 release from cells ...
As per a recent study conducted by James Guevara, M.D., of the University of Pennsylvania School of Medicine and colleagues, adults and children with asthma can have better control over asthma with inhaled corticosteroids than with cromolyn.. In this study, comparisons were made between the two treatments (inhaled corticosteroids and cromolyn) to find the better of the two.. It was found that adult asthma patients had three fewer severe asthma flare-ups each year on an average with inhaled steroids (such as the brand names Pulmicort, Flovent, and Beclovent) as against inhaled cromolyn, sold under the brand name Intal. These findings yielded the same results for children.. The study also found that asthma patients (adults and young children) taking steroids scored considerably higher on the tests of lung function besides making less use of asthma inhalers than those taking cromolyn.. ...
Read the Patient Information Leaflet provided by your pharmacist before you start using cromolyn and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth 30 minutes before meals and at bedtime, usually 4 times daily or as directed by your doctor. If you are using this drug to prevent a food allergy or for inflammatory bowel disease, your doctor may direct you to take it 15-20 minutes before meals. Do not swallow the ampules. The contents of the ampules are used to make a solution. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. To make the solution, break open the ampule(s) and squeeze the liquid into a glass of water. Do not mix with fruit juice, soda, milk, or any fluid except plain water. Stir the solution well. Drink all of the solution immediately. Do not mix it ahead of time. Do not take the ampules out of their foil pouch until right before using. ...
The present invention relates to a mast cell inhibitor, a pharmaceutical composition and a method for the treatment of patients afflicted with Parkinsons disease, wherein said patients are treated with a tyrosine kinase inhibitor or mast cell inhibitor, in particular masitinib, or a compound selected from imatinib, cromolyn sodium, midostaurin, BLU-285, bosutinib, ibrutinib, LAS189386, DP-2618, fostamatinib, dasatinib, sunitinib, axitinib, pazopanib, and toceranib or a pharmaceutically acceptable salt or solvate thereof, optionally in combination with at least one pharmaceutically active ingredient.
Treating rhinitis in many ways is similar to treating sinusitis. Decongestants and antihistamines may be prescribed for patients with bronchial asthma who do not experience adverse excessive dryness and plugging of the bronchial tubes. A saline nasal mist can help provide moisture to the nasal lining. Intranasal topical corticosteroid sprays (beclomethasone, budesonide, triamcinolone, mometasone, flunisolide, fluticasone) and cromolyn sodium are extremely helpful in treating rhinitis. These agents do not produce excessive dryness and may be preferred over decongestants and antihistamines. Adverse effects of topical corticosteroid nasal sprays include minor irritation or stinging and, rarely, bleeding from the nasal lining ...
A drug commonly used for the prevention of allergies and asthma has shown promise in preventing liver disease and reducing the need for transplants, says a study.. The study, conducted in mice, found that cromolyn sodium successfully blocked a series of cells that trigger liver scarring (known as fibrosis), which in advanced cases can lead to cirrhosis.. The research was a direct outgrowth of previous published works involving the same drug for bile duct damage and liver cancer.. If you base it off these studies, the possibility of reducing or preventing fibrosis in patients could be very high, said one of the researchers, Heather Francis from Baylor Scott & White Health in Texas, US.. The finding, published in the journal Hepatology, could most impact patients with primary sclerosing cholangitis (PSC), a chronic disease that damages bile ducts and causes serious liver damage.. The disease has no effective treatments and leaves patients with few options beyond a liver transplant.. In ...
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Journal of Drug Delivery is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of therapeutic delivery and targeting. The journal serves researchers from academia and industry, and will publish articles ranging from basic biology of drug and gene delivery through to application and development of these principles. Articles describing drug dosage forms will be considered.
Disodium Phosphate or DSP is a white hygrospic inorganic compound. Disodium Phosphate is one of the several sodium phosphates and is soluble in water. Disodium Phosphate or DSP is most commonly used commercially as an anti-caking agent. DSP is available in both hydrate and anhydrous forms. Disodium Phosphate can be used in a wide range of applications ...
EIB is an important problem with a complex cause. The short-acting, inhaled anti-inflammatory drug nedocromil sodium has been evaluated as prophylaxis for this condition in several small studies; however, its effect on EIB is still controversial. The meta-analysis of 20 randomized controlled trials by Spooner and colleagues clearly shows that 4 mg of inhaled nedocromil sodium taken before exercise is effective in EIB and decreases the exercise-induced reduction in airflow by 50% and the time to recover to normal lung function by more than 50%. Patients with the most severe EIB symptoms achieved the greatest benefit. This study is a well-done meta-analysis with rigorous methodology. The limitations of the review are clearly described, and 2 are of particular interest to clinicians. First, all studies were done in the exercise laboratory under controlled conditions of temperature, humidity, exercise type, and presumably low aero-allergen exposure. As the cause of EIB is complex and these factors ...
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Nedocromil is an anti-allergic medicine that can reduces certain symptoms after you are exposed to an allergen. Nedocromil ophthalmic (for the eyes) is used to treat itching of the eyes caused by allergies. Nedocromil ophthalmic may also be used for purposes not listed in this medication guide.
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5. Patients must be on a stable dose of Anti-H1 for a minimum of 4 weeks before screening and should remain at a stable dose throughout the study period. For other symptomatic treatments, if the patient takes corticosteroids, Anti-H2 or PPI or Antidepressants or Cromoglycate Sodium or Antileucotriene, the treatment must have started at least 4 weeks before Screening and must be stable throughout the study ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
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Browse many computed properties for this monoclinic Na2Tl2B10O17 compound, including formation energy from the elements, energy of decomposition into the set of most stable materials at this chemical composition, bulk crystalline density, and band gap. Also known as: Disodium dithallium decaborate. Cite this material using DOI 10.17188/1268023.
Intranasal cromolyn sodium may be used in patients older than two years. A Cochrane review concluded that it is unclear whether ...
Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US ... Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms. Cromoglicate is ...
... antihistamines and cromolyn sodium may be effective. The intake of diaminoxidase (DAO) in capsule form with meals may reduce ...
Mast cell stabilizers (such as cromolyn sodium) are another non-preferred alternative to corticosteroids. For children with ... Fish oil dietary supplements (marine n-3 fatty acids) and reducing dietary sodium do not appear to help improve asthma control ... Pogson Z, McKeever T (March 2011). "Dietary sodium manipulation and asthma". The Cochrane Database of Systematic Reviews (3): ...
"Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal ...
A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current ...
... cromolyn sodium, and leukotriene receptor antagonists such as montelukast. Oftentimes, medications do not completely control ... Other measures that may be used second line include: decongestants, cromolyn, leukotriene receptor antagonists, and ... Second line therapies include antihistamines, decongestants, cromolyn, leukotriene receptor antagonists, and nasal irrigation. ...
Budesonide Mometasone furoate Cromolyn sodium Nedocromil sodium Zafirlukast Montelukast Zileuton Omalizumab Pentamidine ...
The disodium salt of cromolyn is also used as drug. Most of these salts are sodium salts of organic carboxylic acids or ... sodium bromide, sodium iodide, sodium sulfate, sodium bicarbonate and sodium carbonate. Sodium amide (NaNH2) is the sodium salt ... Sodium salts can be categorized into: sodium salts of carboxylic acids (e. g. sodium formate, HCOONa, the sodium salt of formic ... The sodium salts of fatty acids may serve as soaps and can therefore be called sodium soaps. Sodium salts of certain aromatic ...
Treatments proposed include cromolyn sodium and prednisone.[6] References[edit]. *^ Vernia P, Marcheggiano A, Marinaro V, ...
Aromatic ammonia Dornase alfa Glutathione Insulin Methacholine Nicotine Sodium chloride nail polish remover glue paint thinner ... Nitric oxide Beclomethasone Budesonide Ciclesonide Cromolyn Dexamethasone Flunisolide Fluticasone Mometasone Nedocromil ...
cromolyn sodium. *Nedocromil. *β-agonists. HistoryEdit. Currently most people who use an antihistamine to treat allergies use a ...
Nasal steroids, antihistamines such as diphenhydramine, cromolyn sodium, leukotriene receptor antagonists such as montelukast, ... cromolyn sodium, and leukotriene receptor antagonists such as montelukast.[5] Medications are, however, not sufficient or are ... Other measures that may be used second line include: decongestants, cromolyn, leukotriene receptor antagonists, and ... cromolyn, leukotriene receptor antagonists, and nasal irrigation.[13] Antihistamines by mouth are suitable for occasional use ...
... sodium is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and ... cromolyn, and nedocromil". U.S. Food and Drug Administration. 13 April 2010. Archived from the original on 2 February 2012. v t ... Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis. Nedocromil is classified ... Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Retrieved ...
Fluoroquinolones, sodium sulfacetamide, or trimethoprim/polymyxin may be used, typically for 7-10 days. Cases of meningococcal ... Antihistamines (e.g., diphenhydramine) or mast cell stabilizers (e.g., cromolyn) may be used to help with the symptoms. ... With some chemicals, above all with caustic alkalis such as sodium hydroxide, necrosis of the conjunctiva marked by a ...
Fluoroquinolones, sodium sulfacetamide, or trimethoprim/polymyxin may be used, typically for 7-10 days.[14] Cases of ... cromolyn) may be used to help with the symptoms.[11] Povidone-iodine has been suggested as a treatment, but as of 2008, ... With some chemicals, above all with caustic alkalis such as sodium hydroxide, necrosis of the conjunctiva marked by a ...
Cromolyn Sodium Nasal Solution: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using cromolyn,. *tell your doctor and pharmacist if you are allergic to cromolyn or any other drugs. ... Cromolyn is used with a special applicator (Nasalmatic). Before you use cromolyn for the first time, read the instructions ... Use cromolyn exactly as directed. Do not use more or less of it or use it more often than directed or prescribed by your doctor ...
CROMOLYN SODIUM (UNII: Q2WXR1I0PK) (CROMOLYN - UNII:Y0TK0FS77W) CROMOLYN SODIUM. 40 mg in 1 mL. ... Cromolyn sodium is poorly absorbed. When multiple doses of cromolyn sodium ophthalmic solution are instilled into normal rabbit ... One drop contains approximately 1.6 mg cromolyn sodium.. Patients should be advised that the effect of cromolyn sodium ... Cromolyn Sodium Ophthalmic Solution USP, 4% is contraindicated in those patients who have shown hypersensitivity to cromolyn ...
Cromolyn Sodium (UNII: Q2WXR1I0PK) (Cromolyn - UNII:Y0TK0FS77W) Cromolyn Sodium. 40 mg in 1 mL. ... Cromolyn Sodium Ophthalmic Solution USP, 4% Sterile It is important to use Cromolyn Sodium Ophthalmic Solution regularly, as ... Cromolyn sodium is poorly absorbed. When multiple doses of cromolyn sodium ophthalmic solution are instilled into normal rabbit ... Cromolyn Sodium Ophthalmic Solution is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or ...
Cromolyn Sodium eent reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI ... Cromolyn sodium nasal solution USP patient information. Tampa, FL. Undated.. 216. Bausch & Lomb. Crolom (cromolyn sodium) ... One drop of cromolyn sodium ophthalmic solution contains approximately 1.6 mg of cromolyn sodium.205 b ... Cautions for Cromolyn Sodium. Contraindications. * Known hypersensitivity to cromolyn sodium or any ingredient in the ...
Find treatment reviews for Cromolyn sodium from other patients. Learn from their experiences about effectiveness, side effects ...
Find the most comprehensive real-world treatment information on Cromolyn sodium at PatientsLikeMe. 25 patients with ... bipolar I disorder or mild depression currently take Cromolyn sodium. ...
Cromolyn sodium is used to treat the symptoms of a condition called mastocytosis, which can cause diarrhea, nausea, vomiting, ... headaches, stomach pain, itchy skin, and flushing (warmth or redness under the skin). Cromolyn... ... Cromolyn sodium works by preventing the release of substances in the body that cause inflammation. ... What is cromolyn sodium?. Cromolyn sodium works by preventing the release of substances in the body that cause inflammation. ...
... includes cromolyn sodium ophthalmic description, dosage and directions. ... Physician reviewed cromolyn sodium ophthalmic (ophthalmic) patient information - ... Cromolyn sodium (ophthalmic). Generic Name: cromolyn sodium (ophthalmic) (KROE moe lin off THAL mik). Brand Name: Crolom, ... What is cromolyn sodium ophthalmic?. Cromolyn sodium works by preventing the release of substances in the body that cause ...
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... cromolyn sodium (oral)) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to ... cromolyn sodium (oral). *What is cromolyn sodium (Gastrocrom)?. *What are the possible side effects of cromolyn sodium ( ... Do not use cromolyn sodium if it looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new ... Break open the cromolyn sodium ampule and squeeze the liquid into a glass of water. Stir this mixture and drink all of it right ...
Experimental: Oral cromolyn Subjects randomized to the experimental arm will receive oral cromolyn sodium. The dose will be per ... Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis. The safety and scientific validity of this study is the ... Drug Information available for: Cromolyn sodium Cromoglicic acid Genetic and Rare Diseases Information Center resources: ... Cromolyn Sodium. Esophageal Diseases. Gastrointestinal Diseases. Digestive System Diseases. Gastroenteritis. Eosinophilia. ...
Cromolyn sodium was added to the patients regimen as part of the care program for his bronchial asthma. Within 20 minutes of ... AHMAD S. Cromolyn Sodium and Anaphylaxis. Ann Intern Med. 1983;99:882. doi: 10.7326/0003-4819-99-6-882_2 ...
Cromolyn sodium in the management of systemic mastocytosis.. Horan RF1, Sheffer AL, Austen KF. ... A multicenter, double-blind, placebo-controlled trial of the efficacy of oral cromolyn sodium (200 mg orally four times per day ... Efficacy variables were compared for a 4-week baseline period, during which patients received open-labeled cromolyn sodium, and ... cromolyn sodium treatment was significantly beneficial relative to placebo (p less than 0.02), whereas the benefit for ...
NasalCrom (Cromolyn Sodium) Is Surprisingly Helpful for Allergies. Are you sneezing, sniffling and congested? Are allergies ... Cromolyn (NasalCrom) was first introduced as a prescription product in 1983. NasalCrom went over the counter in 1997. Cromolyn ... The compound cromolyn stabilizes highly sensitive mast cells in the lining of the nose and lungs so they can better resist the ... Cromolyn is very safe and does not cause drowsiness or rebound nasal congestion the way OTC nasal decongestants can. Some ...
Cromolyn Sodium Trial in Perennial Asthmatics. David A. Mathison, M.D.; John J. Condemi, M.D., F.A.C.P.; Frank W. Lovejoy Jr., ... Cromolyn sodium has been administered (20 mg powder inhalation, four or more times daily) in open trial to 29 adults with ... Cromolyn sodium (disodium cromoglycate), an inhibitor of antigen-antibody-induced mediator release, has been shown to prevent ... Cromolyn Sodium Trial in Perennial Asthmatics.. Ann Intern Med. 1970;72:810-811. doi: 10.7326/0003-4819-72-5-810_4 ...
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Cromolyn is an anti-allergy agent used to treat itching, redness, and irritation of the eyes due to seasonal allergies. ... Step by Step Use of Cromolyn Sodium Cromolyn (Sodium Cromoglycate). This particular medicine has been termed as a mast cell ... If needed, you can easily buy Cromolyn sodium eye drops easily online. They can be bought from Canada Pharmacy. ... Generic Equivalent (Cromolyn (Sodium Cromoglycate) Eye Drops). Select A Size.... Generic 2% Eye Drops 5 mL - $14.00 Generic 4% ...
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"Cromolyn Sodium" by people in this website by year, and whether "Cromolyn Sodium" was a major or minor topic of these ... "Cromolyn Sodium" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: ... Below are the most recent publications written about "Cromolyn Sodium" by people in Profiles. ...
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Mansour, H., Xu, Z., & Hickey, A. (2007). Characterization of dry powder aerosols of albuterol sulfate and cromolyn sodium with ... Characterization of dry powder aerosols of albuterol sulfate and cromolyn sodium with various sugar carriers delivered by ...
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  • Intal Inhaler (Cromolyn Sodium Inhalation Aerosol) Patient. (steroids-australia.net)
  • Who should not use cromolyn inhalation aerosol? (sharecare.com)
  • If you have certain medical conditions, including arrhythmia or heart disease, coronary artery disease, kidney disease or liver disease, you may not be able to use cromolyn inhalation aerosol or your doctor may need to adjust your dosage. (sharecare.com)
  • Cromolyn inhalation aerosol is not known to affect an unborn baby when taken by a pregnant woman, but it may pass into breast milk. (sharecare.com)
  • You should not use cromolyn inhalation aerosol if you are breastfeeding without discussing the risks and benefits with your doctor. (sharecare.com)
  • You should not use cromolyn inhalation aerosol if you are allergic to any of its ingredients. (sharecare.com)
  • What should I avoid while taking cromolyn sodium? (cigna.com)
  • Cromolyn sodium was added to the patient's regimen as part of the care program for his bronchial asthma. (annals.org)
  • Cromolyn sodium (disodium cromoglycate), an inhibitor of antigen-antibody-induced mediator release, has been shown to prevent acute asthma in allergic subjects when inhaled prior to challenge with inhalant allergens. (annals.org)
  • Cromolyn sodium has been administered (20 mg powder inhalation, four or more times daily) in open trial to 29 adults with perennial asthma who had been corticoid-dependent and who completed a 14-week double blind, double crossover trial comparing cromolyn sodium and placebo. (annals.org)
  • Murphy KR, Fitzpatrick S, Cruz-Rivera M, Miller CJ, Parasuraman B. Effects of budesonide inhalation suspension compared with cromolyn sodium nebulizer solution on health status and caregiver quality of life in childhood asthma. (umassmed.edu)
  • Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial. (umassmed.edu)
  • There is evidence to indicate that exposure to Cromolyn Sodium (an asthma preventer) during pregnancy may have a teratogenic effect on the fetus. (rightdiagnosis.com)
  • Cromolyn sodium nasal will not treat the symptoms of asthma, sinus infections, or the common cold. (healthridgemedical.com)
  • Cromolyn has been approved in the United States for asthma therapy since 1973. (meta.org)
  • Currently, cromolyn is a first line therapy for mild to moderate asthma requiring chronic treatment. (meta.org)
  • Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. (meta.org)
  • Cromolyn works by acting on certain inflammatory cells in the lungs to prevent the release of substances that cause asthma symptoms. (pharmacychecker.com)
  • Inhaled Cromolyn has a favorable safety profile and having been used for asthma treament for several decades since the sixties, including children and pregnant women, and with renewed interest in for repurposing in other diseases, has well-studied pharmacokinetics (37). (bmj.com)
  • Estimates of inhaled asthma medications (beta-agonists, steroids, and cromolyn) dispensed in each area in 1992 were obtained from IMS America. (nih.gov)
  • A handout on this topic is available at https://familydoctor.org/familydoctor/en/diseases-conditions/asthma/treatment.html . (aafp.org)
  • Cromolyn Sodium (Cromolyn Sodium) are medications treat them with the seriousness. (lcmeds.com)
  • In the US, Customers can order Cromolyn Sodium Inhalation Solution online as well as many more quality medications from PrescriptionPoint.com. (prescriptionpoint.com)
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  • These customers can remain calm knowing that they are receiving Cromolyn Sodium Inhalation Solution all their other prescription medications from a trustworthy pharmacy. (pharmapassport.com)
  • Customers can order Cromolyn Sodium Inhalation Solution online and many other quality medications from PharmaPassport.com at an affordable price. (pharmapassport.com)
  • Treatments for symptoms of hay fever include medications such as antihistamines, decongestants, steroid nasal sprays, leukotriene inhibitors, cromolyn sodium , and immunotherapy ( allergy shots ). (emedicinehealth.com)
  • Cromolyn is used to prevent and treat stuffy nose, sneezing, runny nose, and other symptoms caused by allergies. (medlineplus.gov)
  • Cromolyn sodium is used to treat the symptoms of a condition called mastocytosis, which can cause diarrhea, nausea, vomiting, headaches, stomach pain, itchy skin, and flushing (warmth or redness under the skin). (cigna.com)
  • Cromolyn sodium ophthalmic (for the eyes) is used to treat allergy symptoms that affect the eyes, such as itching, burning, watering, swelling, redness, or sensitivity to light. (drugs.com)
  • Do not wear contact lenses while using cromolyn sodium, or when you have allergy symptoms affecting your eyes. (drugs.com)
  • The average physician assessment of disease severity and symptom scores of the patients in the placebo-treated group increased significantly during the randomization phase relative to patients in the cromolyn sodium-treated group, reflecting an exacerbation of symptoms with drug withdrawal (p less than 0.05 and less than 0.028, respectively). (nih.gov)
  • It contains cromolyn, which stabilizes the mast cells in the nose responsible for many, if not most, allergy symptoms. (peoplespharmacy.com)
  • More detailed information about the symptoms , causes , and treatments of Cromolyn Sodium -- Teratogenic Agent is available below. (rightdiagnosis.com)
  • Cromolyn sodium nasal (for the nose) is used to prevent or relieve allergy symptoms such as runny nose, stuffy nose, sneezing, and itching. (healthridgemedical.com)
  • Use cromolyn sodium nasal only during times when you are in contact with things that cause your allergy symptoms. (healthridgemedical.com)
  • CROMOLYN SODIUM (KROE moe lin SOE dee um) is used to treat the symptoms of mastocytosis. (kramesonline.com)
  • Patients may use cromolyn sodium's gentle, preventive action to ease periodic hay fever discomfort or to reduce symptoms of year-round allergies to dust mites, pets and other indoor irritants. (livestrong.com)
  • Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms. (wikipedia.org)
  • Not known whether cromolyn is distributed into milk. (drugs.com)
  • It is not known whether cromolyn sodium passes into breast milk or if it could harm a nursing baby. (cigna.com)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or to any of the other ingredients. (nih.gov)
  • it is contraindicated for use in patients with a known hypersensitivity to cromolyn or to other product ingredients. (uprx.com)
  • A multicenter, double-blind, placebo-controlled trial of the efficacy of oral cromolyn sodium (200 mg orally four times per day) was conducted in 11 patients with systemic mastocytosis who had been maintained with the drug on an individualized compassionate-need basis. (nih.gov)
  • Efficacy variables were compared for a 4-week baseline period, during which patients received open-labeled cromolyn sodium, and at 4-week intervals during a 16-week period of random assignment to cromolyn sodium or placebo. (nih.gov)
  • One hundred eligible patients with clinical diagnosis of moderate VKC were randomly assigned to Zaditen (Group A, n=50) and Cromolyn sodium (Group B, n=50) eye drops for a 4 week period. (medicaljournal-ias.org)
  • A clear response to treatment occurred in 94.4% of Zaditen patients and 81.2% of sodium Cromoglycate patients. (medicaljournal-ias.org)
  • Mold allergy patients should begin taking cromolyn sodium before seasonal fungal levels climb. (livestrong.com)
  • Intranasal cromolyn sodium may be used in patients older than two years. (wikipedia.org)
  • Cromolyn sodium (Intal) may be used for vasomotor rhinitis associated with sneezing and congestion in patients older than two years. (aafp.org)
  • Interestingly, University of California that previously tested Aminocaproic acid for erythema, now enrolling patients to test Cromolyn Sodium. (rosaceagroup.org)
  • The Medication Coupons.com Drug Savings card saves you up to 85% or more on Cromolyn Sodium Oral Inhalation . (medicationcoupons.com)
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  • Cromolyn sodium doesn't act as quickly or last as long as some other types of allergy medicines, but the makers of this gentle, over-the-counter nasal spray report few side effects. (livestrong.com)
  • Cromolyn sodium may also be used for purposes not listed in this medication guide. (cigna.com)
  • cromolyn belongs to a class of medication known as mast cell stabiliser, and it inhibits the release of a natural chemical that can swell the airways and lead to breathing problems. (canadapharmacy.com)
  • The Cromolyn Sodium Inhalation Solution medication above is manufactured by Pharmascience Inc. (prescriptionpoint.com)
  • A prescription must be provided for Cromolyn Sodium Inhalation Solution and all our prescription medication here at PharmaPassport.com. (pharmapassport.com)
  • The Cromolyn Sodium Inhalation Solution medication you purchase is manufactured by Pharmascience Inc. Sodium Cromoglycate - Generic is the generic alternative to Cromolyn Sodium Inhalation Solution. (pharmapassport.com)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is indicated in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. (nih.gov)
  • The purpose of this study is to compare the efficacy of Ketotifen fumarate 0.025% (Zaditen) with Cromolyn sodium 4% eye drops in prevention of itching, tearing and redness in vernal keratoconjunctivitis (VKC). (medicaljournal-ias.org)
  • In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine release than cromolyn sodium. (elsevier.com)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is a clear, colorless, sterile solution intended for topical ophthalmic use. (nih.gov)
  • When multiple doses of cromolyn sodium ophthalmic solution are instilled into normal rabbit eyes, less than 0.07% of the administered dose of cromolyn sodium is absorbed into the systemic circulation (presumably by way of the eye, nasal passages, buccal cavity and gastrointestinal tract). (nih.gov)
  • If needed, you can easily buy Cromolyn sodium eye drops easily online. (canadapharmacy.com)
  • CROMOLYN SODIUM (KROE moe lin SOE dee um) helps reduce inflammation. (va.gov)
  • CROMOLYN SODIUM (KROE moe lin SOE dee um) helps block allergic reactions. (aahs.org)
  • CROMOLYN SODIUM (KROE moe lin SOE dee um) helps to relieve seasonal eye allergies. (nm.org)
  • Cromolyn comes as a solution to use with a special nasal applicator. (medlineplus.gov)
  • Before you use cromolyn for the first time, read the instructions provided with the solution. (medlineplus.gov)
  • Cromolyn Sodium Inhalation Solution is a sterile, aqueous solution of Cromolyn Sodium. (drugfuture.com)
  • Identification The UV absorption spectrum of the Assay preparation prepared as directed in the Assay exhibits maxima and minima at the same wavelengths as that of a similar solution of USP Cromolyn Sodium RS , concomitantly measured. (drugfuture.com)
  • Assay preparation Dilute with water an accurately measured volume of Inhalation Solution, equivalent to about 25 mg of cromolyn sodium, to obtain a solution having a concentration of about 250 µg per mL. (drugfuture.com)
  • Pipet 10 mL of this solution into a 100-mL volumetric flask, add 1 mL of pH 7.4 Sodium phosphate buffer , dilute with water to volume, and mix. (drugfuture.com)
  • Procedure Concomitantly determine the absorbances of the Standard preparation and the Assay preparation in 1-cm cells at the wavelength of maximum absorbance at about 326 nm, with a suitable spectrophotometer, using a 1 in 100 aqueous solution of pH 7.4 Sodium phosphate buffer as the blank. (drugfuture.com)
  • PrescriptionPoint.com guarantees the best price for Cromolyn Sodium Inhalation Solution and will beat any other price found on a CIPA certified website for the same drug by 5 dollars. (prescriptionpoint.com)
  • A prescription must be provided for Cromolyn Sodium Inhalation Solution as with all prescription medicine here at PrescriptionPoint.com. (prescriptionpoint.com)
  • Drug Description : When ordering Cromolyn Sodium Inhalation Solution be sure to choose a reputable online pharmacy that you trust. (pharmapassport.com)
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  • Cromolyn sodium acts by inhibiting the release of histamine and SRS-A (slow-reacting substance of anaphylaxis) from the mast cell. (nih.gov)
  • Available as a nasal spray and an ophthalmic drop, cromolyn sodium acts to prevent the release of histamine. (pharmacytimes.com)
  • tell your doctor and pharmacist if you are allergic to cromolyn or any other drugs. (medlineplus.gov)
  • What other drugs will affect cromolyn sodium? (cigna.com)
  • Other drugs may interact with cromolyn sodium, including prescription and over-the-counter medicines, vitamins, and herbal products. (cigna.com)
  • In vitro and in vivo animal studies have shown that cromolyn sodium inhibits the degranulation of sensitized mast cells which occurs after exposure to specific antigens. (nih.gov)
  • Another activity demonstrated in vitro is the capacity of cromolyn sodium to inhibit the degranulation of non-sensitized rat mast cells by phospholipase A and the subsequent release of chemical mediators. (nih.gov)
  • Cromolyn Sodium prevents the release of inflammatory chemicals such as histamine from mast cells. (rosaceagroup.org)
  • Cromolyn sodium in the management of systemic mastocytosis. (nih.gov)
  • Cromolyn sodium works by preventing the release of substances in the body that cause inflammation. (cigna.com)
  • In addition to many substances that have been described to inhibit NF-kB and hence may be candidates for attentuating inflammation responses in SARS-COV2 infection (10,11), Cromolyn may be proposed as an adjunct treatment. (bmj.com)
  • Cromolyn has been found to be effective in reducing inflammation pathways in several other diseases (16 - 22). (bmj.com)
  • can anti-histamine + nasal irrigation + cromolyn sodium spray help reduce chronic nasal turbinate, nasopharynx inflammation & mucus membrane swelling? (healthtap.com)
  • In normal volunteers, analysis of drug excretion indicates that approximately 0.03% of cromolyn sodium is absorbed following administration to the eye. (nih.gov)
  • Cromolyn sodium carries no serious side effects or drug interactions, even when taken every day. (livestrong.com)
  • Even though cromolyn may help some people I have been been impressed with its efficacy. (healthtap.com)
  • Cromolyn may cause side effects. (medlineplus.gov)
  • What are the possible side effects of cromolyn sodium? (cigna.com)
  • Possible side effects of cromolyn sodium include: headaches nasal irritation cough wheezing dizziness nausea body aches drowsiness Talk to your doctor if you experience any of these side effects while taking cromolyn sodium. (uprx.com)
  • Do not use cromolyn sodium nasal without a doctor's advice if you are pregnant or breast-feeding a baby. (healthridgemedical.com)
  • Trace amounts (less than 0.01%) of the cromolyn sodium dose penetrate into the aqueous humor and clearance from this chamber is virtually complete within 24 hours after treatment is stopped. (nih.gov)
  • We investigated 49 asthmatic children (38 treated with beclomethasone dipropionate (BDP) at a daily dose of 276+/-125 microg/day and 11 treated with cromolyn sodium (CS) at a daily dose of 30+/-10 mg/day) for 7.4 months, with bone-mass measurements at baseline and after the treatment period. (nih.gov)
  • Cromolyn sodium is poorly absorbed. (nih.gov)
  • Cromolyn is a white crystalline powder which is poorly absorbed from the gastrointestinal tract. (meta.org)
  • Cromolyn sodium has no intrinsic vasoconstrictor, antihistaminic or anti-inflammatory activity. (nih.gov)
  • Cromolyn has been found to have broader anti-inflammatory and anti-tumor mechanisms than what has been described historically as an antiallergy and mast cell stabilizer (12). (bmj.com)
  • Cromolyn Sodium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same. (google.com.au)