Critical Pathways: Schedules of medical and nursing procedures, including diagnostic tests, medications, and consultations designed to effect an efficient, coordinated program of treatment. (From Mosby's Medical, Nursing & Allied Health Dictionary, 4th ed)Hospital Costs: The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).Utilization Review: An organized procedure carried out through committees to review admissions, duration of stay, professional services furnished, and to evaluate the medical necessity of those services and promote their most efficient use.Efficiency, Organizational: The capacity of an organization, institution, or business to produce desired results with a minimum expenditure of energy, time, money, personnel, materiel, etc.Length of Stay: The period of confinement of a patient to a hospital or other health facility.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Postoperative Care: The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Cardiology: The study of the heart, its physiology, and its functions.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Geranium: A plant genus of the family GERANIACEAE. Geranium is also used as a common name for PELARGONIUM.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Economics, Nursing: Economic aspects of the nursing profession.Terminal Care: Medical and nursing care of patients in the terminal stage of an illness.ItalyCopyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Pneumonia: Infection of the lung often accompanied by inflammation.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Equipment Reuse: Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Autonomic Pathways: Nerves and plexuses of the autonomic nervous system. The central nervous system structures which regulate the autonomic nervous system are not included.alpha Catenin: A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Cytoskeletal Proteins: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Cell Line, Tumor: A cell line derived from cultured tumor cells.Night Blindness: Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)Sperm Count: A count of SPERM in the ejaculum, expressed as number per milliliter.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Lethargy: A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.White spot syndrome virus 1: A species of DNA virus, in the genus WHISPOVIRUS, infecting PENAEID SHRIMP.Alopecia: Absence of hair from areas where it is normally present.Smell: The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Culture Media, Serum-Free: CULTURE MEDIA free of serum proteins but including the minimal essential substances required for cell growth. This type of medium avoids the presence of extraneous substances that may affect cell proliferation or unwanted activation of cells.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Glycogen Synthase Kinase 3: A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.Electron Transport Complex IV: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.Rhodobacter sphaeroides: Spherical phototrophic bacteria found in mud and stagnant water exposed to light.IllinoisCytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Proton Pumps: Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

Experience with a managed care approach to HIV infection: effectiveness of an interdisciplinary team. (1/353)

To evaluate the function and effectiveness of a multidisciplinary team for managing human immunodeficiency virus (HIV) infection, we conducted a follow-up cohort study of HIV-positive patients managed according to a clinical care path at a staff-based health maintenance organization (HMO). The study group consisted of 230 HIV-positive health plan members who received care at the Kaiser Permanente Santa Rosa medical center (KPMC-SRO). In 1994, the comparison group consisted of 4747 HIV-positive health plan members who received care at Kaiser Permanente's 18 other medical centers in northern California. The percentages of acquired immunodeficiency syndrome (AIDS) and HIV-positive patients as determined by CD4+ T-cell counts were similar (P = 0.97). Compared with patients at the other Kaiser Permanente medical centers, KPMC-SRO patients had more visits with nurse practitioners (rate ratio [RR] = 1.72) and nutritionists (RR = 12.3) and fewer visits with primary care physicians (RR = 0.82). More HIV-positive members at KPMC-SRO received social workers' services (27% at KPMC-SRO vs 6% for patients at the other Kaiser Permanente medical centers) and fewer used emergency services (RR = 0.92) and psychiatric services (RR = .89). At KPMC-SRO, the mean number of days that AIDS patients spent in the hospital decreased from 7.8 (1991) to 2.01 (1994). Hospital admissions were fewer (AIDS patients, RR = 0.67; HIV-positive patients without AIDS, RR = 0.45), and length of stay was briefer, compared with patients at the other Kaiser Permanente Medical Centers. The mean cost of HIV-related drugs for patients seen at KPMC-SRO ($2343 per infected member) was lower than that for patients seen elsewhere in the region ($3289 per infected member). These results suggest that in an HMO setting, managed care provided by a dedicated interdisciplinary team according to a clinical care path can substantially and favorably affect resource use.  (+info)

The development and implementation of normal vaginal delivery clinical pathways in a large multihospital health system. (2/353)

The entire country has become more concerned with healthcare costs due to managed care, capitation risk-based contracts, and the near elimination of the cost-plus reimbursement system. Clinical pathways have become one way to reduce unnecessary resource consumption by reducing provider variance, improving clinical outcomes, and reducing cost. We present here our rationale and process for developing a common clinical pathway for normal vaginal delivery in a large and varied multihospital system. We also discuss how this new pathway is expected to improve quality of care and reduce costs.  (+info)

Influence of a critical path management tool in the treatment of acute myocardial infarction. Clinical Quality Improvement Network Investigators. (3/353)

OBJECTIVE: The primary objective of this study was to determine the effect of implementing a critical path on use of proven efficacious therapies and outcomes in patients admitted to a hospital with acute myocardial infarction (AMI). The secondary objectives were to evaluate the use of unproven medications and to develop an understanding of the factors associated with adverse in-hospital outcomes in these patients. STUDY DESIGN: A nonrandomized before-after study design was used to evaluate the efficacy of a critical path instrument in patients admitted to hospital with AMI. PATIENTS AND METHODS: Consecutive patients admitted with AMI in nine participating hospitals were enrolled in the study. The critical path instrument consisted of a locally developed, preprinted physician order form. Practice patterns were determined before (n = 2305) and after (n = 2349) implementation of the critical path by primary chart review. Multivariate analysis of risk factors for mortality was performed on a combined database of 6088 AMI patients. RESULTS: The use of acetylsalicylic acid (ASA), nitrates, and beta blockers increased significantly by 3%, 2%, and 9%, respectively, after implementation of the critical path. Use of thrombolytics remained stable at 41%, and calcium channel blocker use decreased significantly by 8%. In-hospital mortality decreased by 1%. There was less use of ASA, nitrates, beta blockers, and thrombolytic therapy in women and the elderly. Multivariate analysis showed that advanced age was associated with increased mortality risk, whereas ASA, beta blockers, nitrates, and calcium channel blockers were associated with reduced mortality risk. CONCLUSION: Implementation of a critical path resulted in increased use of proven efficacious therapies, reduced use of noneffective therapy, and a trend toward reduced mortality.  (+info)

Evaluating and improving the delivery of heart care: the University of Michigan experience. (4/353)

With increasing pressure to curb escalating costs in medical care, there is particular emphasis on the delivery of cardiovascular services, which account for a substantial portion of the current healthcare dollar spent in the United States. A variety of tools were used to improve performance at the University of Michigan Health System, one of the oldest university-affiliated hospitals in the United States. The tools included initiatives to understand outcomes after coronary bypass operations and coronary angioplasty through use of proper risk-adjusted models. Critical pathways and guidelines were implemented to streamline care and improve quality in interventional cardiology, management of myocardial infarction, and preoperative assessment of patients undergoing vascular operations. Strategies to curb unnecessary costs included competitive bidding of vendors for expensive cardiac commodities, pharmacy cost reductions, and changes in nursing staff. Methods were instituted to improve guest services and partnerships with the community in disease prevention and health promotion.  (+info)

Infrarenal aortic surgery with a 3-day hospital stay: A report on success with a clinical pathway. (5/353)

PURPOSE: This paper reports on an experience with a clinical pathway for elective infrarenal aortic surgery (AS) that targeted hospital discharge on postoperative day (POD) 3. The pathway incorporated early feeding, early ambulation, and selective use of the intensive care unit (ICU). METHODS: A review of 50 consecutive hospital discharges after AS (aneurysm repair and aortofemoral bypass grafting) by a single surgeon performed from April 1996 through June 1998 with this clinical pathway is reported. The data collected included morbidity rate, mortality rate, length of stay (LOS), and number of hospital readmissions. RESULTS: The average LOS for all patients was 3.0 days. Only six patients (12%) were admitted to the ICU. Discharge on POD 3 was achieved in 80% of the group (40 of 50), and increasing experience improved compliance, with 92% of the most recent 25 patients (23 of 25) being discharged by POD 3. Eleven of these 25 patients (44%) were discharged on POD 2. No patient was readmitted to the hospital within a 30-day period after discharge. There was no mortality after AS during this period. CONCLUSION: Factors that limit the discharge of patients recovering from AS include the ability to ambulate independently and to tolerate a diet. Ambulation and feeding on POD 1 were well tolerated by most patients, which shortened the period of hospitalization. Admission to the ICU was infrequently required when a monitored surgical step-down unit was available. Discharge by POD 3 for AS has been proven to be routinely achievable, safe, and well accepted by patients and to reduce the cost of hospitalization.  (+info)

The role of clinical practice guidelines in disease management. (6/353)

This activity is designed for medical directors, pharmacy directors, quality assurance managers, and all members of disease management or quality improvement teams. GOAL: To review the guideline literature and help healthcare organizations plan guideline development and implementation strategies. OBJECTIVES: 1. Clarify the terminology used in practice policy development. 2. Explain how guideline implementation is related to disease management. 3. Discuss interventions utilized to enhance guideline adoption. 4. Provide a stepwise plan for healthcare organizations to follow.  (+info)

New picture archiving and communications system plus new facility equals critical path planning challenge. (7/353)

The architectural design and construction of a new imaging department is one of the most complex challenges in healthcare architecture. When a client also plans a simultaneous change in basic operating system technology from film-based to filmless imaging, the challenge for both hospital management and the facility/technology design team is even more complicated. A purposeful planning process plus a carefully composed team of internal and external experts are the two essentials for success in executing this difficult conversion of both facility and technology.  (+info)

A community hospital-based congestive heart failure program: impact on length of stay, admission and readmission rates, and cost. (8/353)

OBJECTIVE: To do an analysis of patients with a primary diagnosis of congestive heart failure at discharge before (n = 407) and after (n = 347) the implementation of a comprehensive inpatient and outpatient congestive heart failure program consistent with the guidelines of the Agency for Health Care Policy and Research. STUDY DESIGN: A retrospective analysis of the impact of the congestive heart failure program on length of stay, admission and readmission rates, and costs to both patient and provider. The program, which used a multidisciplinary team approach, included an intensive education program focusing on diet, compliance, and symptom recognition, as well as the use of outpatient infusions. It also incorporated aggressive pharmacologic treatment for patients with advanced congestive heart failure. RESULTS: Our analysis revealed significant decreases in length of stay, admission and readmission rates, and costs to the patient and provider (P < or = .05). The mean cost per admission decreased 17% ($1118), and a substantial 77% ($718,468) net reduction in nonreimbursed (lost) hospital revenue was noted. CONCLUSION: A multidisciplinary, comprehensive congestive heart failure program can improve patient care in a community-hospital setting while significantly reducing costs to both the patient and the institution.  (+info)

*Obesity paradox

Critical Pathways in Cardiology. 5 (4): 187-90. doi:10.1097/01.hpc.0000249784.29151.54. PMID 18340236. Pearson, T. A. (2007). " ...

*Axonotmesis

Critical Pathways in Therapeutic Intervention. Missouri: Mosby Inc. p. 262. ISBN 0-323-00105-X. "Nerve Injury (Neuropraxia, ...

*Saturated fat

Cannon, Christopher; O'Gara, Patrick (2007). Critical Pathways in Cardiovascular Medicine, 2nd Edition. Lippincott Williams & ... There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity ... Critical Reviews in Food Science and Nutrition (Review). 56 (12): 1947-51. doi:10.1080/10408398.2015.1018037. PMID 25764080. ...

*Peripartum cardiomyopathy

Critical Pathways in Cardiology (10): 44-45. "UOTW #14 - Ultrasound of the Week". Ultrasound of the Week. 20 August 2014. ...

*Fundic gland polyposis

Chung, DC (2000). "The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis". Gastroenterology ... Both the β-catenin gene and the APC gene are involved in the same cell growth signalling pathway, but the APC gene is known to ...

*Clinical prediction rule

However, when the prediction rule is implemented as part of a critical pathway, so that a hospital or clinic has procedures and ... Marrie TJ, Lau CY, Wheeler SL, Wong CJ, Vandervoort MK, Feagan BG (2000). "A controlled trial of a critical pathway for ...

*KiSS1-derived peptide receptor

Seminara SB (2006). "Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion". Frontiers ... "Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating ...

*Clinical pathway

A clinical pathway, also known as care pathway, integrated care pathway, critical pathway, or care map, is one of the main ... Maturen, Virginia; Van Dyck, Lisa (February 1996). "Using outcome-based critical pathways to improve documentation". Journal of ... Clinical pathways (integrated care pathways) can be seen as an application of process management thinking to the improvement of ... Clinical pathways can range in scope from simple medication utilization to a comprehensive treatment plan. Clinical pathways ...

*PTPRK

"Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell ... A critical role for the novel extracellular MAM domain". J Biol Chem. 270 (24): 14247-50. doi:10.1074/jbc.270.24.14247. PMID ...

*European Pathway Association

Use and evaluation of critical pathways in hospitals. Eff Clin Pract 2002; 5:114-119. De Luc K., Developing care pathways - the ... International survey on the use and dissemination of clinical pathways in 23 countries, Journal of Integrated Care Pathways, ... The European Pathway Association (E-P-A.org) is a European non-profit organisation which brings together researchers, managers ... The organisation works on the establishment of clinical care pathways in order to systematically plan and follow up a patient ...

*Surgical scheduling software

... for example implementation of guidelines and critical pathways.", Sittig DF, Stead WW: Computer-based physician order entry: ...

*Agostino Gemelli University Polyclinic

The Hospital uses "Critical Pathways" to map, integrate and assess every phase involved in providing care for key health ...

*Health care quality

Critical Pathways Critical Pathways are outcome-based and patient-centered case management tools that take on an ... Using critical pathways to reduce costs and errors improves quality by providing a systematic approach to assessing health care ... critical pathways, and risk management. Clinical Practice Guideline "Technical performance" is the extent to which a health ... Health care managers utilize critical pathways as a method to reduce variation in care, decrease resource utilization, and ...

*Saturated fat and cardiovascular disease

According to the 2007 Critical Pathways in Cardiovascular Medicine, substituting unsaturated fat for saturated fat may lower ...

*Epithelioid sarcoma

This is a critical pathway in angiogenesis, a process that cancer cells use to form new blood vessels, which provide necessary ... Upon ligand binding, EGFR phosphorylation triggers the activation of downstream signaling pathways involved in critical ... The mTOR pathway has been described as a "master switch" for cellular catabolism and anabolism, and it can enhance cell cycle ... They also can be used against the c-KIT and JAK-STAT signaling pathways, which are involved in many cancers and may be involved ...

*Hypoxanthine-guanine phosphoribosyltransferase

This finding implies that HPRT is a critical pathway that helps preserve the cell's purine nucleotide resources under hypoxic ... HAT medium inhibits de novo synthesis of nucleic acids, killing myeloma cells that cannot switch over to the salvage pathway, ... HGPRT plays a central role in the generation of purine nucleotides through the purine salvage pathway. HGPRT catalyzes the ... HGPRTase functions primarily to salvage purines from degraded DNA to reintroduce into purine synthetic pathways. In this role, ...

*Simon Fisher

His subsequent research has used FOXP2 and other language-related genes as molecular windows into neural pathways critical for ...

*List of MeSH codes (N04)

... critical pathways MeSH N04.590.374 --- delivery of health care MeSH N04.590.374.034 --- after-hours care MeSH N04.590.374.034. ... critical pathways MeSH N04.590.233.675 --- patient-centered care MeSH N04.590.233.727 --- primary health care MeSH N04.590. ...

*Door-to-balloon

Although incorporating a prehospital 12 lead ECG into critical pathways for STEMI patients is listed as an optional strategy by ... "Heart Attack Care In Critical Condition," CBS News, November 13, 2006. Accessed July 3, 2007. "Hospitals Seek to Speed Up ... "community-based initiative aimed at quickly activating the appropriate chain of events critical to opening a blocked artery to ...

*41st G7 summit

... identifies critical pathways through which climate change is likely to have significant interactions with the stability and ...

*Cholera toxin

"Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult ...

*Secreted frizzled-related protein 1

It has been shown that the deregulation of this critical developmental pathway occurs in several human tumor entities. SFRP1 is ... The Wnt/Ca2+ and Wnt/polarity pathways are known as the "non-canonical pathways". The decision of which pathway is activated ... The majority of research has focused on the Wnt/β-catenin pathway (also known as the "canonical" Wnt pathway), which manages ... The Wnt signaling pathways are initiated by the binding of the Wnt ligand to the Fz receptor. There are three different ...

*Clare Waterman

... and identified a molecular pathway critical for this mechanosensing. This work provided a biophysical mechanism for the role of ... Cell migration is critical to development, immune response, and tissue maintenance, and is compromised in disease and ... Cellular mechanosensing is critical to embryonic development and is thought to drive cancer metastasis. Dr. Waterman and ... Such events are of critical importance in development, the immune response and wound healing, as well as in metastatic cancer. ...

*Nir Barzilai

Barzilai, N; Huffman, DM; Muzumdar, RH; Bartke, A (June 2012). "The critical role of metabolic pathways in aging". Diabetes. ... "Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans". PLoS Biol. 4 (4): e113. doi:10.1371/journal. ...

*Orofaciodigital syndrome 1

Cilia defects adversely affect numerous critical developmental signaling pathways essential to cellular development. Other ...

*Atrioventricular node

... "pathway" has a slow conduction velocity but shorter refractory period the second "pathway" has a faster conduction velocity but ... BMPs) are multifunctional signaling molecules critical for the development of AV node. BMP influences AV node development ... AV conduction during normal cardiac rhythm occurs through two different pathways: the first " ...
Synonyms for critical pathway in Free Thesaurus. Antonyms for critical pathway. 4 synonyms for pathway: nerve pathway, nerve tract, tract, footpath. What are synonyms for critical pathway?
Suboptimal quality of care is an evident issue in current healthcare services. Clinical pathways (CPs) have the potential to facilitate evidence-based practice and interprofessional teamwork, and thereby improve patient safety and quality of care.. The overall aim of the thesis was to develop comprehensive empirical knowledge and understanding of CP implementation and teamwork in Swedish intensive care units (ICUs). Four studies were included (I-IV).. Study I was a survey including all Swedish ICUs (N84) and a document analysis of CP examples (n12). In total, 17 (20%) ICUs used CPs and many had implementation plans. The quality, extent and content of the CPs (n56) varied greatly, with sometimes insufficient interprofessionalism, evidence base and renewal.. Study II was a mixed method including ICUs using CPs. The implementation processes were retrospectively explored through questionnaire data (n15) and qualitative content analysis of interviews with key informants (n10). The CP implementation ...
ASCO today released Criteria for High-Quality Clinical Pathways in Oncology, a set of 15 inter-related criteria that provide an overarching framework for assessing pathway programs in the United States. ASCO developed the criteria to guide stakeholders in assessing the quality, utility, and integrity of clinical pathways in oncology.. Rising health-care costs and the overall shift toward a value-based health-care delivery system have led to the rapid proliferation of clinical pathways in oncology. In fact, according to DK Pierce & Associates, Inc, an estimated 60 individual health insurance plans in the United States are currently using or developing oncology-specific pathways, and in 2010, approximately 15% of oncology "covered lives" were treated according to clinical pathways-a number which was expected to rise to 25% in 2015, according to McKinsey & Company.. "Well-designed and effectively implemented clinical pathways can support the delivery of evidence-based cancer care, while enhancing ...
BACKGROUND AND PURPOSE: The International Subarachnoid Aneurysm Trial (ISAT) reported that endovascular coiling yields better clinical outcomes than surgical clipping at 1 year. The high cost of the consumables associated with the endovascular coiling procedure (particularly the coils) led health care purchasers to conclude that coiling was a more costly procedure overall. To examine this assumption and provide evidence for future policy, accurate and comprehensive data are required on the overall resource usage and cost of each strategy. METHODS: We provide detailed results of patient treatment pathways, resource utilization, and costs up to 24 months postrandomization for endovascular and neurosurgical treatment of aSAH. We report data on costs related to initial and subsequent procedures (ward days, ITU, equipment, staff, consumables, etc), adverse events, complications, and follow up. The data are based on a subsample of all patients randomized in ISAT, containing all patients across 22 UK centers
Definition of clinical pathway in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is clinical pathway? Meaning of clinical pathway as a legal term. What does clinical pathway mean in law?
Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol Shiekha AlAujan,1 Saja AlMazrou,1 Roger D Knaggs,1,2 Rachel A Elliott11Division for Social Research in Medicines and Health, The School of Pharmacy, University of Nottingham, Nottingham, UK; 2Pharmacy Department and Pain Management Service, Nottingham University Hospitals NHS Trust, Nottingham, UKBackground: Low back pain (LBP) and fibromyalgia (FM), also known as chronic widespread pain (CWP), are highly prevalent chronic painful conditions that have substantial impact on patients, health care systems, and society. Diagnosis is complex and management strategies are associated with various levels of evidence for effectiveness and cost-effectiveness. Multidisciplinary pain services have been shown to be effective in some settings and therefore are recommended by clinical
An easy-to-follow summary of the Primary Care Dermatology Society treatment pathway for the assessment and management of psoriasis based on site of psoriasis.
An easy-to-follow summary of the Primary Care Dermatology Society treatment pathway for the assessment and management of psoriasis based on site of psoriasis.
Evershed, S. (2010) A Treatment Pathway for High Security Offenders with a Personality Disorder, in Working Positively with Personality Disorder in Secure Settings: A Practitioners Perspective (eds P. Willmot and N. Gordon), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470973110.ch5 ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Clinical pathways are becoming important to the provision of efficient and effective health care. A clinical pathway is a tool by which a clinical practice guideline based on the best available evidence is adapted for implementation in a specific setting. Pathways involve input from all members of the healthcare team and form part or all of the patients record, allowing documentation of interventions, progress, and outcome. Pathways promote standardisation of care and may be based on diagnoses, symptoms, or procedures.1 Campbell et al suggest that although a sizeable literature exists about the development of care pathways, there are few evaluations of their effectiveness in changing practice and improving patient outcomes.2 The study by Dowsey et al is one of the first randomised controlled trials to evaluate the effectiveness of a clinical pathway.. Strengths of the study include random allocation to comparison groups by a clerical assistant who was unaware of the patients clinical profile ...
Objective: To design, implement and assess a clinical pathway for lower-extremity deep venous thrombosis, and to compare the length of hospital stay in two different periods.. Design: Development of the care pathway by a multidisciplinary team, followed by a controlled intervention study to compare two non-concomitant cohorts of patients corresponding to the years 2002 (before the implementation of the critical pathway) and 2004 (year of the implementation).. Setting: Academic tertiary care hospital.. Participants: 90 patients, 42 corresponding to the year 2004 and 48 to 2002, admitted to hospital with a diagnosis of lower-extremity deep venous thrombosis (DVT).. Main outcome measures: Length of hospital stay, hospitalisation costs and care indicators.. Results: The mean length of hospital stay was 6.78 days in 2002 and 4.72 days in 2004. This means a reduction of 2.06 days (p,0.012). The reduction in the length of hospital stay in 2004 situates the hospital 1.98 days below the mean stay of our ...
BCB Medical is a provider of pioneering information systems to the health care sector. Our clinical pathway systems are designed to assist doctors and nursing staff in their everyday management of clinical pathways for the benefit of their patients.. We serve as your guide in the world of information management and bring a strong trio of support to clinical pathway implementation: efficiency improvement, treatment quality and effectiveness follow-up, and comparability of medical information.. BCB Medical. ScanBalt Business Club. ...
Background. Clinical pathways are increasingly being used by hospitals to improve efficiency in the care of certain patient populations ; however little prospective data are available to support their use. This study examined whether using a clinical pathway for patients undergoing ileal pouch/anal anasto-mosis, a complex procedure in which we...
And appropriate items in the clinical pathway are listed in the following eight categories: treatment; medications; observation, including a check of vital signs; laboratory tests, such as complete blood count and blood chemistry; activity; nutrition; education; and variance (Fig. 8). Based on the clinical pathway process, we treated patients with benign prostate hypertrophy. At hospitalization, nurse specialists in the urological ward educated the patient and his family about the pre- and post operation process. Through such multidisciplinary collaboration, the length of hospitalization and hospital costs were successfully reduced, while the quality care indicators were all maintained. This chapter describes the development of this clinical pathway and also demonstrates the outcomes after implementation. Key Words. Clinical pathway, Transurethral resection of prostate, Length of hospitalization, Hospital charge Introduction The concept of developing clinical pathways originated in the ...
Systems useful for analyzing data related to clinical pathways and performing actions based upon the analyses. A self-analyzing system for suggesting default clinical pathways for various procedures. A self-analyzing system for suggesting deviation from a current clinical pathway and entry into an alternative clinical pathway based upon historical information about the results of actions. Statistical analysis systems based on clinical pathways. A rating system for care providers or proposed pathways based on historical information. Systems for gathering clinical pathway information. Systems for tracking clinical pathway outcomes based on data collected post-treatment. A system for prequalification for appropriate discharge and post-discharge handling of and communication with a new class of patient, those requiring stable acute care. A questionnaire computer language and subsystem are used in various stages of the systems of the invention. Corresponding methods are also disclosed.
BACKGROUND: Hospital is the most common place of cancer death but concerns regarding the quality of end-of-life care remain. AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to adult cancer patients during their last week of life in hospital. DESIGN: Uncontrolled before-after intervention cluster trial. SETTINGS/PARTICIPANTS: The trial was performed within four hospital wards participating in the pilot implementation of the Italian version of the Liverpool Care Pathway programme ...
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TABLE-US-00001 TABLE 1 Dynamic Biomarkers and Applications Physiological/ Clinical or Medical Medical Area Biomarker Disease or Condition Molecule of interest Metabolism/ adipose triglyceride Obesity; lipoatrophy; Glycerol or fatty Nutrition/Endo- dynamics fat distribution; acids derived from crinology hyperplasia- triglyceride. hypertrophy Adipocyte dynamics hyperplasia- DNA isolated from hypertrophy; response adipocytes to compounds or therapeutics. Muscle mitochondrial Unfitness; DNA from muscle DNA or phospholipid cardiovascular disease mitochondria or dynamics risk; autotoxicity phospholipids (e.g., drugs; deconditioning; cardiolipin) from frailty muscle mitochondria. Muscle protein Frailty; wasting; Protein derived dynamics sports; dystrophies from muscle (e.g., total muscle protein or myosin) Dynamics of adipose Atherosclerosis; Glycerol or fatty lipolysis diabetes mellitus risk acids derived from triglyceride. Dynamics of adipose or carbohydrate Fatty acids hepatic overfeeding; anabolic ...
Background and Aims: Our understanding of patient pathways through specialist Alcohol and Other Drug (AOD) treatment and broader health/welfare systems in Australia remains limited. This study examined how treatment outcomes are influenced by continuity in specialist AOD treatment, engagement with non-AOD community services, and mutual aid, as well as exploring differences between clients who present with a primary alcohol problem compared to those presenting with a primary drug issue. Method: In a prospective, multi-site treatment outcome study, 796 clients from 21 AOD services in Victoria and Western Australia completed a baseline interview between January 2012 and January 2013. 555 (70%) completed follow-up assessment of subsequent service use and AOD use outcomes 12-months later. Results: Just over half of the participants (52.0%) showed reliable reductions in use of, or abstinence from, their primary drug of concern. This was highest among clients who reported meth/amphetamine (66%) as ...
Methods We developed a 10-year Markov model describing the treatment pathway of patients with PsA who had failed prior oral DMARD therapy, using monthly cycles. Clinical efficacy data were obtained from published pivotal study results and literature. Costs, resource utilisation and treatment pathways were obtained from the literature and expert opinion. Patients transitioned through two lines of biologics (etanercept, infliximab, golimumab or adalimumab as first or second line) followed by best supportive care. Response to therapy was defined as the probability of PsARC response at the end of the trial period. Patients transitioned to the next line of therapy in case of non-response or discontinuation due to other causes (a short-term annual drop-out rate of 32% and a long-term rate of 16.5% were assumed). All-cause death was included and adjusted to reflect the increased mortality associated with PsA. Treatment and administration, monitoring, and hospitalisation costs were included. An annual ...
Observational research promises to complement experimental research by providing large, diverse populations that would be infeasible for an experiment. Observational research can test its own clinical hypotheses, and observational studies also can contribute to the design of experiments and inform the generalizability of experimental research. Understanding the diversity of populations and the variance in care is one component.
Acta Neurochir (2017) 159:1457-1478. An understanding of the present standing of surgery, surgical results and the role in altering the future morbidity and mortality of untreated brain arteriovenous malformations (bAVMs) is appropriate considering the myriad alternative management pathways (including radiosurgery, embolization or some combination of treatments), varying risks and selection biases that have contributed to confusion regarding management. The purpose of this review is to clarify the link between the incidence of adverse outcomes that are reported from a management pathway of either surgery or no intervention with the projected risks of surgery or no intervention.. Methods A critical review of the literature was performed on the outcomes of surgery and non-intervention for bAVM. An analysis of the biases and how these may have influenced the outcomes was included to attempt to identify reasonable estimates of risks.. Results In the absence of treatment, the cumulative risk of ...
A network cabinet is provided comprising a base member, two pairs of vertical frame rail members connected to the base member, and a top cover supported by at least one of the vertical frame rail members. The base member defines an opening and another opening is defined in the top cover. The vertical frame rail members are positioned spaced apart from four sidewalls from four corners of the cabinet formed by the four sidewalls, where each sidewall comprises a panel or a door. The two pairs of vertical frame rail members and the four sidewalls define at least one cable management pathway and at least a portion of the cable management pathway is vertically aligned with at least a portion of the opening of the base member and the opening of the top cover.
Rationale, aims and objectives Clinical pathways (CPs) can improve quality of care on intensive care units (ICUs), but are infrequently utilized and of varying quality. Knowledge regarding factors that facilitate versus hinder successful implementation of CPs is insufficient and a better understanding of the activities and individuals involved is needed. The aim of this study was to explore the implementation process of CPs within the context of ICUs. Methods An exploratory design with a sequential mixed method was used. A CP survey, including all Swedish ICUs, was used to collect quantitative data from ICUs using CPs (n = 15) and interviews with key informants (n = 10) were used to collect qualitative data from the same ICUs. Descriptive statistics and qualitative content analysis were used, and the quantitative and qualitative findings were integrated. Results The CP implementation was conceptualized according to two interplaying themes: a process to realize the usefulness of CPs and create ...
Health care providers and payers are increasingly turning to clinical pathways as tools to manage the cost of care and promote evidence-based treatment.
novel download clinical pathways in vitreoretinal pages and mesoscopic organs of having called to Join in intrinsically evolutionary germ-line achievements. The survival and number of the indexing 499K)Article was However only comprehensive to the valuable skills evolved on the Murray River is. Yet my wide day at that water was of a tangent of emergency from the discrete-time in its calories to the material involving across its speaking.
Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on managment guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, hematologists, neurologists, intensivists, pharmacists, and nurse practitioners ...
Today, this isolated relationship[ he is speaking of the physician patient relationship] is no longer tenable or possible… Traditional medical ethics, based on the doctor-patient dyad must be reformulated to fit the new mold of the delivery of health care...Regulation must evolve. Regulating for improved medical care involves designing appropriate rules with authority...Health care is being rationalized through critical pathways and guidelines. The primary function of regulation in health care, especially as it affects the quality of medical care, is to constrain decentralized individualized decision making. ...
I am working on a new approach to painting that is based on an unique pictorial technique I have developed called Overlapping. This process, I believe, is able to open up a novel critical pathways within painting and the perception of pictorial space and its role within the contemporary art thinking. I am interested in creating a series of new artworks capable of symbolizing how the health status of the human body can be emotionally affected and this therefore becomes embodied within a psychosomatic medical disorder. www.stefanialaccu.com/ ...
Chemical atherogenesis is an emerging field that describes how environmental pollutants and endogenous toxins perturb critical pathways that regulate lipid metabolism and inflammation, thus injuring cells found within the vessel wall. Despite growing awareness of the role of environmental pollutants in the development of cardiovascular disease, the field of chemical atherogenesis can broadly include both exogenous and endogenous poisons and the study of molecular, biochemical, and cellular pathways that become dysregulated during atherosclerosis. This integrated approach is logical because exogenous and endogenous toxins often share the same mechanism of toxicity. Chemical atherogenesis is a truly integrative discipline because it incorporates concepts from several different fields, including biochemistry, chemical biology, pharmacology, and toxicology. This review will provide an overview of this emerging research area, focusing on cellular and animal models of disease.
SummarySomatic mutation analysis of melanoma has been performed at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last 5 yr, next-generation sequencing (NGS
If youve had back pain that has gone on for more than a couple of weeks and is starting to affect your work or personal life, speak to your GP. There is a wide choice of treatment pathways and your GP will recommend the one that works best for your situation.. This blog is brought to you by DoctorDoctor who provides access to in-home after-hours medical care for GPs and their patients in Melbourne, Perth, Sydney, and Brisbane.. Medical information published on this website is of a general nature only and not intended to be a substitute for informed healthcare professional advice or clinical care. If you have specific healthcare concerns or issues you should consult with a qualified health care professional such as your own GP.. ...
A study, published in the American Journal of Respiratory and Critical Care Medicine, describes a new treatment pathway for antibiotic resistant bacteria and infectious diseases with benefits for patients and health care providers. Researchers from the University of Birmingham and Newcastle University found that the unusual approach of removing antibodies from the blood stream reduced…
The US Food and Drug Administration has approved Roches diagnostic test for KRAS mutations to help physicians select the most effective treatment pathway for patients with advanced colorectal cancer. - News - PharmaTimes
Scottish prostate cancer patients will now be able to get treatment with Janssens Zytiga much earlier in the treatment pathway, after the Scottish Medicines Consortium had a change of heart and endorsed the drugs use before chemotherapy. - News - PharmaTimes
Autumn 2015 Contents Welcome...1 What we are calling for...2 Background information...3 Better understanding...4 Clear treatment pathways...5 Appropriate diagnosis and reporting...6 Summary of actions
PCD-related marker gene in tobacco increased more quickly in The BiP is one of the most important chaperone proteins the control cell lines compared with that in the over-expressing that assist in maintaining physiological function of the ER. The cell lines. However, the PCD-related NtHsr203J may be induced BiP protein not only protects peptide folding and preserves Ca2+ by ER stress through a pathway independent of the UPR (Iwata homeostasis but also acts as a modulator of the UPR and ER and Koizumi, 2005b). Therefore, determining whether the Cd2+- stress-cell death signaling pathways. The amount of NtBLP4 tran- induced ER stress-cell death occurs through another signaling script was less than that in control cells under CdCl2 treatment pathway requires further research. Some researchers have found when AtBiP2 was constitutively expressed in BY-2 cells (Fig. 5A and that signaling of plant-specific N-rich protein (NRP) mediates ER B). Therefore, the exogenous BiP protein reduced ER damage ...
Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet
Boehringer Ingelheimhas struck a deal which positions the German drugmaker to participate in digital diabetes care. The pact between Boehringer and digital health outfit Healthrageous involves a study of Type 2 diabetics, who are expected to receive a combination of digital coaching, wireless glucose monitoring and other tools to manage their disease.
Results: 144 clinicians completed the survey, gaining a 21.8% response rate. 54% (95% CI 46%, 62%) of clinicians felt like they had good knowledge, leaving 46% of clinicians feeling a lack of knowledge. 94% (95% CI 89%, 97%) thought emergency departments should treat sepsis immediately or within the first hour. Case studies highlighted variability in the management pathways chosen and 98% (95% CI 94%, 99%) of clinicians required further training. 97% (95% CI 92%, 99%) agreed a screening tool would assist in the identification of septic patients and 98% (95% CI 95%, 99%) would use the tool ...
HMP Communications LLC (HMP) is the authoritative source for comprehensive information and education servicing healthcare professionals. HMPs products include peer-reviewed and non-peer-reviewed medical journals, national tradeshows and conferences, online programs and customized clinical programs. HMP is a wholly owned subsidiary of HMP Communications Holdings LLC. © 2017 HMP Communications. © 2018 HMP Communications ®. ...
First, can you describe why COA believes physician dispensing to be a valuable way of helping patients to achieve better outcomes? As cancer treatment shifts from physician-administered chemotherapy infusions to oral cancer drugs, being able to dispense these complex, potentially toxic specialty drugs is essential to effective, coordinated cancer care. Providing these drugs at the point-of-care provides greater assurance that patients will receive their drugs, be instructed on how to take them, and communicate any medication issues with their providers. What are some of the chief concerns COA has about PBMs aims to restrict physician dispensing, and why do you think those changes might be detrimental to patient health? Requiring patients with cancer to get their drugs from mail-order prescriptions from PBMs limits access to treatment, disrupts care management, and increases the cost of care-all of which affect patient outcomes and prognosis. More specifically, it:. • limits and delays patient ...
HMP Communications LLC (HMP) is the authoritative source for comprehensive information and education servicing healthcare professionals. HMPs products include peer-reviewed and non-peer-reviewed medical journals, national tradeshows and conferences, online programs and customized clinical programs. HMP is a wholly owned subsidiary of HMP Communications Holdings LLC. © 2017 HMP Communications. © 2017 HMP Communications ®. ...
HMP Communications LLC (HMP) is the authoritative source for comprehensive information and education servicing healthcare professionals. HMPs products include peer-reviewed and non-peer-reviewed medical journals, national tradeshows and conferences, online programs and customized clinical programs. HMP is a wholly owned subsidiary of HMP Communications Holdings LLC. © 2017 HMP Communications. © 2017 HMP Communications ®. ...
Use IQ Scripts to gain control over your clinical processes. IQ Scripts define patient pathways and clinical protocols, and how MOSAIQ collects data.
The completion rate of the clinical pathway was 45.6% (115/252). Mean length of stay was 11.7 ± 8.6 (8 - 59 days). Readmission rate was 4.4% (11/252). In multivariate analysis, laparoscopic gastrectomy (odds ratio = 0.511) and subtotal gastrectomy (odds ratio = 5.251) were important factors to fail clinical pathway. Causes of failure for clinical pathway were intra-abdominal complications (32.8%), patient factors (29.9%) and wound complications (21.9%). ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
This paper demonstrates that data-driven clinical pathways can be developed using electronic health record data to facilitate innovations in practice-based care delivery for chronic disease management.
The Complete Denture: A Clinical Pathway,2e Author(s): Michael I. MacEntee Date: 2014 Format: PDF Language: English https://www.nitroflare.com/view/4C2E7D5
The new data thus adds depth to our understanding of things that go awry in these critical pathways, sometimes promoting cancer formation, other times providing cancer cells with advantages that enable them to crowd out healthy cells, comments Dr. Tuveson, who in addition to leading a lab at CSHL is the Director of CSHLs NCI-designated Cancer Center and Director of Research for the Lustgarten Foundation, the nations largest philanthropic funder of pancreatic cancer research. The cell adhesion pathway affected by newly discovered mutations in gene promoter regions is important for obvious reasons in cancer: cancer cells want to grow and proliferate, a process that can culminate in their migration from their tissue of origin. Once they have broken free, they can travel via the bloodstream to other places in the body, a process called metastasis that is often responsible for cancer fatalities. The axon guidance pathway associated with promoter mutations has a less obvious but no less important ...
University at Buffalo researchers have identified a neural pathway that could hold a key to preventing relapse in individuals recovering from cocaine addiction. Their study focused on the activity of Activin receptors in the brain that are located in regions involved in pleasure and reward.. Published online June 1 in Nature Neuroscience, the study authored by Amy Gancarz, PhD, found that the Activin pathway controls the ability of cocaine to alter the connections between various neurons. By manipulating the activity of Activin receptors, researchers were able to change cocaine-taking behavior in animal models.. "Understanding this critical pathway will help us pursue new directions in potential pharmacological and gene therapies to prevent drug relapses," senior author David Dietz, PhD, assistant professor at the university medical schools Department of Pharmacology and Toxicology, said in a June 18 news release.. ...
Figure 2: Parsley (dried). Apigenin May Assist in the Prevention of Cancer. Apigenin has been shown to possess remarkable anti-carcinogenic properties. 3 There has been significant progress in studying the biological effects of apigenin at cellular and molecular levels as a chemopreventive agent. 4 There are a number of biological effects of apigenin in numerous mammalian systems in vitro as well as in vivo, due to its low intrinsic toxicity and because of its striking effects on normal versus cancer cells. 5 The exact mechanism of apigenin is still being researched, but the current research demonstrates that apigenin affects several critical pathways and/or targets:. ...
For those that view cellular signaling as a tangled mass of cooked spaghetti, a guidebook that introduces shared principles, highlights typical behaviors, and provides clear examples of the uses for these critical pathways should be invaluable. This book provides all of that and more. But it also, perhaps inadvertently, highlights overly reductionist concepts of cellular control. Hopefully, this tome will close the book on that mode of thought and stimulate a new generation to think about and understand how cellular regulation is so tightly integrated-because this is the key to more effective treatments for disease.. ...
On the 28th January 2015, the latest presentation in Gedes Mental Health Dialogue Programme was focused on relating behavioral change with mental health. Over 20 attendees listened to the presentation given by Professor Andrew Zamani, Dean of the Social Science Faculty at Nasarawa State University and currently President of the Association of Psychologists in Nigeria.. Professor Zamani highlighted the roles of behavior change in achieving mental health through the following lenses: conceptual issues, diagnostic criteria, consequences of mental impairment and behavior change imperatives.. It was noted during the session that, in promoting mental health, intervention indices should go beyond the cultural and scientific definitions of abnormal behaviors which are mostly symptom-based, but include enhancement of protective factors and promotion of healthy lifestyle in addition to effective treatment pathways. His presentation was followed by a lively Q and A session. Gedes next Mental Health ...
Interviews with authors of articles from JAMA Oncology. JAMA Oncology is the definitive journal for scientists, clinicians, and trainees in the field of oncology worldwide. Our original, innovative, and timely scientific and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for our readers. JAMA Oncology aims to effectively convey the findings of important clinical research, major scientific breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community. Our goal is that successful communication of new knowledge will ultimately translate to clinical benefit for people living with and surviving cancer.
Our endometriosis clinic at Chelsea and Westminster sees patients from all over the country, many of whom have been referred from their GP because they require a specialist opinion. We work with a variety of people, including those awaiting diagnosis or others who may have a long history of the condition.. On your first visit, its likely that you will be seen by a specialist nurse who will take a detailed history from you and ask about any medications you may be taking or any previous operations you may have had - it would be helpful, although not essential, if you can bring information on either of these with you on the day. If further investigations are required, the nurse will also arrange these for you.. Following this you will be invited back to the clinic to see one of our doctors; sometimes you may see a gynaecology registrar if a consultant is not available. We offer very clear treatment pathways for people affected by endometriosis; sometimes this may mean surgery but can also involve ...
Some brand names of eye drops have been included in brackets for information, but please always prescribe eye drops generically.. Note: The Northern (NHS) Treatment Advisory Group does not recommend the use of high-dose vitamin and mineral supplements in the prevention of progression of AMD.. Note: The Northern (NHS) Treatment Advisory Group recommends the sequential pharmacological management of MO secondary to RVO as per the North East Retina Group (NERG) RVO treatment pathway.. CD&D APC Patient Decision Aids Resource available at: http://medicines.necsu.nhs.uk/guidelines/durham-darlington/. CD&D APC "Do Not Prescribe List" and "Grey List - drugs prescribed under limited circumstances" available at: http://medicines.necsu.nhs.uk/guidelines/durham-darlington/. ...
We conducted a retrospective cohort study based on a case note review to determine whether there are differences in the treatment pathways followed for men and women admitted with acute myocardial ischemia and infarction after adjusting for differences in case mix. Women were as likely as men to receive thrombolysis, but were less likely...
Disclaimer: The information and data in this document ("Information") is based on scientific evidence current as of the date issued and is subject to change without notice. The Information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Any person consulting or applying the Information is expected to use independent medical judgment and expertise in the context of individual clinical circumstances. Winnipeg Regional Health Authority and the Manitoba Renal Program make no representation or guarantees of any kind whatsoever regarding the content or use or application of the Information and specifically disclaim any responsibility for its application or use in any way. ...
醫院之臨床路徑:醫院的決策制定已經從以意見為基礎轉而尋求以合理的科學證據為依歸。這樣的決策制定被視為是以臨床證據為基礎的執行臨床業務方式。由於新證據不斷的出刊發表,加上日常業務的要求,因此對於醫事人員來說,很難不斷地更新證據。臨床路徑是一個以文件記錄為基礎的工具,將可得的最佳證據與臨床實務之間連結。它們針對特定的症狀以或介入措施提供了建議、流程以及時程。臨床路徑已經被廣泛的運用,但是在許多單一的試驗當中,它的影響結果卻是矛盾不一致的。這篇文獻回顧的目的在總結臨床路徑對於臨床人員執行業務 (如文書品質) 、病人結果 (如死亡率、併發症) 、住院天數以及醫院成本的證據並且評估其影響。 ...
Neutropenic sepsis is a potentially life-threatening complication of chemotherapy and has an associated mortality of 2% to 21%. Patients can deteriorate rapidly and are usually advised to attend their local emergency department (ED) for urgent assessment and antibiotic therapy within one hour of arrival. Delivery of this emergency care is, however, inconsistent, and at times suboptimal, due to a lack of awareness of the condition and of clinical expertise. This article discusses a collaborative project between an acute oncology service and an ED, which has improved and sustained compliance with this standard through a range of initiatives, including revised and integrated sepsis guidelines, education, sepsis champions and a fast-track patient pathway ...
This module will provide students with an opportunity to develop the skills and attitudes needed to be a healthcare science practitioner. Learning is centred on patient presentation and common patient pathways through the health service. Clinical placements will contextualize learning, offer real-life experience and enable students to apply taught professional practice outcomes in order to practise safely. Students will begin a portfolio of evidence and will be required to complete specified sections of the professional training manual.. ...
Making diabetes management effective - the principle aim of the integrated diabetes management program of the hospital. Aimed at combating the menace of diabetes in India, Apollo group of hospitals will launch 100 Sugar Clinics around the country in 90 days. These clinics will manage the life cycle of a diabetic and work towards minimizing the associated morbidity and mortality. These clinics working on a specifically developed clinical pathway will offer standardized care to the diabetic
The first difference is that we do not produce a single product or service. Every patient is different, and every patient expects and deserves personalized service and individualized attention. Not so different, you might argue. There are plenty of businesses that offer service tailored to the individual, and they have learned how to provide that service consistently and efficiently. And it is true that, in medicine, there are general rules and appropriate clinical responses for many patients with one or another disease. For example, I have discussed below the use of clinical pathways to make care decisions more routine, and I have discussed protocols that can be used to avoid ventilator-associated pneumonia, central line infections, and other harm. But, at its core, effective treatment really does require due attention to the individual biology of the patient, his or her state at the exact time of treatment, as well as related factors like family and home situations. It is as much art as science ...
The first difference is that we do not produce a single product or service. Every patient is different, and every patient expects and deserves personalized service and individualized attention. Not so different, you might argue. There are plenty of businesses that offer service tailored to the individual, and they have learned how to provide that service consistently and efficiently. And it is true that, in medicine, there are general rules and appropriate clinical responses for many patients with one or another disease. For example, I have discussed below the use of clinical pathways to make care decisions more routine, and I have discussed protocols that can be used to avoid ventilator-associated pneumonia, central line infections, and other harm. But, at its core, effective treatment really does require due attention to the individual biology of the patient, his or her state at the exact time of treatment, as well as related factors like family and home situations. It is as much art as science ...
In November 2016, NICE reviewed this guidance and recommended that it should be withdrawn. The guidance was published in June 2011 and recommended that further research was carried out on the technology. There was insufficient evidence on its use in clinical practice to recommend adoption. On reviewing the guidance in 2016, NICE determined that: The comparator in the original guidance, standard serial troponin testing, was changed in 2014 to high sensitivity troponin testing which expert advice indicated is now widespread in the NHS The clinical pathway in the original evaluation has significantly changed and the original scope is no longer valid. These changes mean that the current guidance is no longer valid and NICE would not be able to update it. The guidance has therefore been withdrawn. For a copy of the review decision please contact [email protected] ...
Neutropenic sepsis is a medical emergency - these patients need immediate assessment and initiation of treatment.. Clinical pathway for neutropenic sepsis. Antibiotic Treatment. Antifungal Treatment. ...
The Generic Pharmaceutical Association sent a letter to President Barack Obama Tuesday saying that provisions relating to intellectual property rights for biotech drugs should not be included in the TPP, a proposed regional trade agreement for the Asia-Pacific region.. The GPhA noted that while implementation of a regulatory approval pathway for biosimilars is ongoing at the Food and Drug Administration, significant disagreement remains about how the law should be implemented and whether further legislation is necessary.. "Given your administrations position and the uncertainty surrounding the pathways implementation by [the] FDA, as well as the critical need to ensure access to safe and affordable medicines in global markets, it is premature to include provisions relating to biologics in any trade agreement," GPhA executive director Bob Billings wrote in the letter.. ...
District nurses spend about 25-65% of their time caring for patients with leg ulcers, with staff time and wound management costs continually rising (Thambiaya, 1996). In the North East London Foundation Trust (NELFT) tissue viability service, a recent internal case load audit was completed for the Essex integrated care directorate.
Immuno-oncology not only refers to the multifaceted relationship between our immune system and a developing cancer but also includes therapeutic approaches that harness the bodys immune system to fight cancer. The recognition that metabolic reprogramming governs immunity was a key finding with important implications for immuno-oncology. In this review, we want to explore how activation and differentiation-induced metabolic reprogramming affects the mevalonate pathway for cholesterol biosynthesis in immune and cancer cells. Glycolysis-fueled mevalonate metabolism is a critical pathway in immune effector cells, which may, however, be shared by cancer stem cells, complicating the development of therapeutic strategies. Additional engagement of fatty acidy oxidation, as it occurs in regulatory immune cells as well as in certain tumor types, may influence mevalonate pathway activity. Transcellular mevalonate metabolism may play an as yet unanticipated role in the crosstalk between the various cell types and
Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades. With current treatments, 60-70 % of patients with localized disease survive. Given a propensity of Wnt signaling to control multiple cellular processes, including proliferation, cell fate determination, and differentiation, it is a critical pathway in OS disease progression. At the same time, this pathway is extremely complex with vast arrays of cross-talk. Even though decades of research have linked the role of Wnt to tumorigenesis, there are still outstanding areas that remain poorly understood and even controversial.. The canonical Wnt pathway functions to regulate the levels of the transcriptional co-activator beta-catenin, which ultimately controls key developmental gene expressions. Given the ...
The Recommendations are based on the results of a pan-European survey spanning 18 European countries and carried out by national patients and civic associations active in the fight against unnecessary pain. The project, entitled Pain Patient Pathway Recommendations, was initiated in November 2012 by a three-member coalition representing patients, citizens and industry, to create greater awareness of chronic pain, to promote a European policy on chronic pain and to improve its management. Working together the Pain Alliance Europe (PAE), the Active Citizenship Network (ACN), and the pharmaceutical company Grünenthal have set as the Recommendations ultimate goal to reduce the impact of chronic pain in Europe. The data, collected through interviews with representatives of national Ministries of Health, patients and citizens associations and healthcare professionals, fed into a project report which set the scene for the development of EU Pain Patient Pathways Recommendations. The Recommendations ...
This is an application for a K08 award for Sunitha Kaiser, MD MSc, a pediatric hospitalist at the University of California, San Francisco. Dr. Kaiser is establi...
Along the severe aortic stenosis (sAS) treatment pathway there are delays that may impact quality management and hospital efficiency. A dedicated valve coordinator, interfering with all stages of patient handling throughout the hospital may increase the efficiency of the sAS patient flow, accelerate decision making and clinical outcomes while at the same time decreasing resource consumption.. The hypothesis is that the implementation of a dedicated valve coordinator will improve the patient flow of sAS patients scheduled to undergo TAVI, their outcome, patient and physician satisfaction and will optimize costs.. In total, three centers across Germany (Munich, Düsseldorf, Bad Bevensen) will participate. ...
MARAIS, LC; FERREIRA, N; ALDOUS, C and LE ROUX, TLB. The management of chronic osteomyelitis: Part I - Diagnostic work-up and surgical principles. SA orthop. j. [online]. 2014, vol.13, n.2, pp.42-48. ISSN 2309-8309.. To date, no evidence-based guidelines for the treatment of chronic osteomyelitis exist. Owing to certain similarities, treatment philosophies applicable to musculoskeletal tumour surgery may be applied in the management of chronic osteomyelitis. This novel approach not only reinforces certain important treatment principles, but may also allow for improved patient selection as surgical margins may be customised according to relevant host factors. When distilled to its most elementary level, management is based on a choice between either a palliative or curative approach. Unfortunately there are currently no objective criteria to guide selection of the most appropriate treatment pathway. The pre-operative diagnostic work-up should be tailored according to the relevant objective, ...
The issue of self-care is now more relevant than ever and the document states we will do more to support people to manage their own health - staying healthy, making informed choices of treatment, managing conditions and avoiding complications. The management of venous leg ulcers fits beautifully into this philosophy as explained in the new Best Practice Statement on Holistic Management of Venous Leg Ulceration (Wounds UK 2016). It also takes readers through a new model of care - a leg ulcer treatment algorithm, where hosiery kits are recommended as first line. This challenges traditional treatment pathways, where compression bandaging has been the first line approach ...
Although early diagnosis and treatment are key factors in the effective control of human African trypanosomiasis (HAT), many cases of the disease delay taking appropriate action, leading to untold suffering. As a better understanding of treatment-seeking behaviour should help in identifying the obstacles to early diagnosis and effective treatment, the treatment pathways followed by 203 former HAT cases in western Kenya and eastern Uganda have recently been explored. About 86% of the HAT cases had utilized more than two different healthcare options before being correctly diagnosed for HAT, with about 70% each using more than three different health facilities. Only about 8% of the cases reported that they had been correctly diagnosed the first time they sought treatment. Just over half (51%) of the HAT cases had been symptomatic for ,2 months before being correctly diagnosed for HAT, and such time lags in diagnosis contributed to 72% of the cases receiving their first appropriate treatment only in ...
Assisted conception and MRKH syndrome. Dr Anna Carby Fertility Specialist IVF Hammersmith. Overview. Reproductive options What is surrogacy treatment Treatment pathway Investigations Treatment cycle Outcomes at IVF Hammersmith. Options. Slideshow 527860 by tevy
The continued rise in cost of Heart failure (HF) management, begs the question, why can advances in science and medicine not stem this rising cost? Why do patients fail to adhere to prescribed medications and lifestyle recommendations? Lack of effective training for patient/families challenge successful transition to home due to conflicts generated by pressure within the patients home environment reinforced by societal attitudes about food. This pilot was designed as a multidisciplinary project, including information systems professionals, clinicians, and patients working together to develop/evaluate a customized mobile phone application (app). Using, home based monitoring of daily weights, blood pressure, heart rate, blood glucose, and a dash board of cumulative data accessed daily by clinicians. A built in algorithm identifies patients risk for re-admission based on changes in their vital signs or self-reported symptoms defined by clinical staff as representing best practices pathways ...
PARSIPPANY, N.J. (PRWEB) February 12, 2015 -- A growing number of oncologists are following standard, scientifically proven treatment algorithms called
Neutropenic sepsis is a potentially life-threatening complication of chemotherapy and has an associated mortality of 2% to 21%. Patients can deteriorate rapidly and are usually advised to attend their local emergency department (ED) for urgent assessment and antibiotic therapy within one hour of arrival. Delivery of this emergency care is, however, inconsistent, and at times suboptimal, due to a lack of awareness of the condition and of clinical expertise. This article discusses a collaborative project between an acute oncology service and an ED, which has improved and sustained compliance with this standard through a range of initiatives, including revised and integrated sepsis guidelines, education, sepsis champions and a fast-track patient pathway ...
Previous to Advancing Quality, Lesley worked in business analysis and business intelligence roles for shared service organisations within the NHS. The primary purpose was to support commissioners and providers of healthcare in making evidence based decisions. In these roles she developed expertise in NHS datasets and information standards and developed technical and product development experience.. Most projects involved analysis of patient cohorts within the health system to bring an understanding of patient flows and support the planning and re-design of clinical service provision in the region. Projects included: predictive risk of hospital admission, contract management and financial flows, and several examples of patient pathway mapping.. Prior to joining the NHS, Lesley worked in technical systems analysis and software development roles for Logica UK. She worked on consulting projects for high profile clients in the energy and utilities sector. ...
Completely updated and in brilliant full color, Merritts Neurology, 13th Edition, remains your reference of choice for outstanding guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. Greatly reorganized for ease of use, the 13th Edition features more than 30 new chapters that keep will you up to date with every aspect of your field. Now for the first time, youll find dozens of video clips online that demonstrate the clinical signs and symptoms of neurologic disorders.
In the current study, we investigated the requirements of MHC I presentation during Chlamydia infection using C57BL/6 mice, the mouse DC line JAWS II, and the nonavian C. psittaci (DC15) as an infection model system. The most intriguing finding of our work is that autophagy constitutes a critical pathway in MHC I processing of chlamydial Ags in infected DCs.. Our data demonstrate that the disease in C. psittaci-infected C57BL/6 mice is comparable to what was recently described for infected cattle (37), the natural host of C. psittaci strain DC15. In particular, the onset of the most pronounced clinical signs due to bronchopneumonia, the pathological features, and the course of disease are remarkably similar. Chlamydia-infected DCs show morphological, as well as functional, maturation, which is characterized by elevated expression of distinct activation/maturation markers and secretion of chemokines/cytokines known to be associated with optimal Ag presentation and clearance of bacterial ...
PCNA ubiquitination in response to DNA damage leads to the recruitment of specialized translesion polymerases to the damage locus. This constitutes one of the initial steps in translesion synthesis (TLS)-a critical pathway for cell survival and for maintenance of genome stability. The recent crystal structure of ubiquitinated PCNA (Ub-PCNA) sheds light on the mode of association between the two proteins but also revealed that paradoxically, the ubiquitin surface engaged in PCNA interactions was the same as the surface implicated in translesion polymerase binding. This finding implied a degree of flexibility inherent in the Ub-PCNA complex that would allow it to transition into a conformation competent to bind the TLS polymerase. To address the issue of segmental flexibility, we combined multiscale computational modeling and small angle X-ray scattering. This combined strategy revealed alternative positions for ubiquitin to reside on the surface of the PCNA homotrimer, distinct from the position ...
To demonstrate how value of information (VOI) analysis can be used to establish research priorities regarding the use of pharmacogenetic tests using CYP2D6 testing to select adjuvant hormonal therapy in early stage breast cancer as a case study. The following four treatment pathways are compared in a Markov model: tamoxifen treatment; CYP2D6 test and treat homozygous and heterozygous wild type patients (wt/wt; wt/ *4) with tamoxifen and *4/ *4 patients with anastrozole (HetTam); CYP2D6 test and treat homozygous wild type patients with tamoxifen and others with anastrozole (HomTam); and anastrozole treatment. Pharmacogenetic testing efficacy is estimated by synthesizing randomized controlled trial data comparing tamoxifen to anastrozole with observational data linking CYP2D6 genotype to tamoxifen outcomes. In order of increasing effectiveness the comparators are tamoxifen, HetTam, HomTam, anastrozole. Health outcomes for test and treatment strategies are highly uncertain. Differences in ...
Ideally, you should ask to speak to a specialist nurse (Continence Adviser) or a Urogynae Physiotherapist. In some areas within the UK, your local health authority may have self-referral continence clinics where you can telephone for an appointment. These clinics are run by specialist nurses who will be able to advise you and offer a treatment pathway. They will also refer you to a urologist or urogynaecologist if further investigation is needed. ...
A University of Rochester study helps to explain why men get liver cancer more often than women and opens the door for a new treatment pathway, by showing a direct link between the androgen receptor, which is more active in men, and the hepatitis B virus as it relates to the deadly cancer.. The study was published May 19, 2010, in Science Translational Medicine, a new journal from the American Association for the Advancement of Science, AAAS.. Primary liver cancer is the fifth most common cancer in men. It often arises after infection from the hepatitis B virus (HBV), which is widespread across the globe and growing in the United States. Other studies of liver cancer have focused on risk factors such as age, family history, and use of alcohol and cigarettes, but those epidemiology studies have not explained the mechanisms driving hepatocellular carcinoma and why men are more susceptible.. Now, corresponding author Chawnshang Chang, Ph.D., the George Hoyt Whipple Distinguished Professor of ...
A study carried out by researchers at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology has shown that using a laser-based treatment on newly diagnosed cases of glaucoma is more successful and more cost-effective than the current method of using intraocular pressure lowering eye drops.. Glaucoma is the name given to conditions which involve increased pressure in the eye causing damage to the optic nerve. It can lead to misty and patchy vision and, if left untreated, can lead to loss of central vision. Glaucoma in some form affects approximately two percent of the UK population over 40 years of age and is one of the leading causes of blindness in the UK.. The three year trial, which is the largest ever of its kind, saw 718 patients newly-diagnosed with glaucoma or ocular hypertension (an increase in pressure in the eye without causing damage to the optic nerve) assigned one of two treatment pathways.. One pathway was the current standard treatment of administering ...
In this study, we have examined whether expression profiling can serve as a more objective method to classify gliomas than histology. Our data show that expression profiling identifies molecular subgroups that are distinct from histologic subgroups and that these molecular subgroups correlate better with patient survival. In addition, our data indicate that distinct molecular subgroups benefit from treatment. As a confirmatory step, the molecular subgroups and their prognostic values were validated on five independent sample cohorts. Finally, specific genetic changes (EGFR amplification, IDH1 mutation, and 1p19q LOH) segregate in distinct molecular subgroups.. At present, the treatment pathway for glioma patients has been optimized for the different histologic subtypes. However, classification based on histologic appearance has a high degree of interobserver variability (3). The intrinsic subtypes of glioma identified in our study therefore provide a robust and objective alternative to ...
While his web persona has been described as a "blogvocateur," Dr. Sidorov has wide range of knowledge about the medical home, condition management, population-based health care and managed care that is only exceeded by his modesty. He has been quoted by the Wall Street Journal, Consumer Reports and NPRs All Things Considered. He has over 20 years experience in primary care, disease management and population based care coordination. He is a primary care general internist and former Medical Director at Geisinger Health Plan. He is primary care by training, managed care by experience and population-based care strategies by disposition. The contents of this blog reflect only the opinions of Sidorov and should not be interpreted to have anything to do with any current or past employers, clients, customers, friends, acquaintances or enemies, personal, professional, foreign or domestic. This is also not intended to function as medical advice. If you really need that, work with a personal physician or ...
The goal of CARE-PATHS is to set up an intelligent operational environment for making Clinical Governance effective, to support Health Professionals, Clinicians and Care Operators, in continually improving the quality of their services and safeguarding high standards of care. The approach adopted by CARE-PATHS is to exploit emerging technologies in knowledge management and semantic web for enabling the methodology of "Clinical Pathways" to function, to be effective and to succeed. The output of the project will be a set of intelligent tools for supporting Health Professionals in authoring conceptual clinical pathways for selected group of pathologies in specific contexts, putting them in practice in the everyday treatment of individual patients, monitoring and managing the variances. CARE-PATHS will be tested in different health scenarios, in Spain and in Italy. From the technological point of view, the objectives are concentrated primarily, in the following technologies of the knowledge ...
Objective: To examine the compass and nature of relevant research and identify gaps in the current evidence in order to determine the priority of future research about breast cancer and intellectual disability (ID).. Methods: A scoping study that comprised of a consultation exercise with a wide range of key stakeholders (n = 26) from one northern city (Sheffield) within the UK.. Results: This study identified numerous gaps in the current evidence base. It highlighted a dearth of research that focuses specifically on the information and support needs of women with IDs (and their carers) across the breast cancer patient pathway. Within the interviews, whilst reasonable adjustments were being made and there was evidence of good practice, they were neither strategic nor systematic. Participants suggested that future research should focus on devising protocols to advise on the legal, ethical and clinical imperatives so that clinical governance in this area is assured.. Conclusions: There remains a ...
The development of treatment guidelines, protocols, and clinical pathways has increased because of 3 divergent forces in medicine.39,40 First, professional organizations are supportive of structured approaches, because these treatment regimens help to ensure that patients receive quality care, as well as increase practitioner awareness of accepted approaches to the provision of care for a particular diagnosis.41,42 A second influence that has contributed to the increased use of treatment protocols is the need to respond to the increased scrutiny of clinical practice by managed care organizations. These types of guidelines make treatment courses and outcomes more predictable. Third, the use of clinical guidelines helps to contain costs while also providing comparable outcomes that can be more accurately evaluated.43,44. The impact of these approaches to date has been limited for AN treatments. Still, AN would seem an ideal candidate for a structured protocol. Historically, guidelines, protocols, ...
UPMC is a global academic medical center headquartered in Pittsburgh, Pennsylvania, United States and it is ranked No. 12 in the U.S. News & World Report Honor Roll of Americas Best Hospitals. UPMC has many clinical and research centers of excellence, including UPMC CancerCenter which is an NCI Designated Comprehensive Cancer Center. In partnership with the University of Pittsburgh Cancer Institute, it maintains rigorous standards in clinical and research quality, consistency, and outcomes at more than 50 outpatient cancer centers. With years of experience, UPMC is helping to develop new models of accountable, cost-efficient, and patient-centered care.. For nearly two decades, UPMC has shared its expertise with public and private partners spanning three continents in cancer center projects including operations management, quality and safety, training, clinical pathways, clinical research, facility and construction management and program design. Through projects in countries such as Italy, ...
UPMC is a global academic medical center headquartered in Pittsburgh, Pennsylvania, United States and it is ranked No. 12 in the U.S. News & World Report Honor Roll of Americas Best Hospitals. UPMC has many clinical and research centers of excellence, including UPMC CancerCenter which is an NCI Designated Comprehensive Cancer Center. In partnership with the University of Pittsburgh Cancer Institute, it maintains rigorous standards in clinical and research quality, consistency, and outcomes at more than 50 outpatient cancer centers. With years of experience, UPMC is helping to develop new models of accountable, cost-efficient, and patient-centered care.. For nearly two decades, UPMC has shared its expertise with public and private partners spanning three continents in cancer center projects including operations management, quality and safety, training, clinical pathways, clinical research, facility and construction management and program design. Through projects in countries such as Italy, ...
President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his work. Unfortunately, this groundbreaking research is being ignored. This negligence is fueling a public health disaster around the world, as critical pathways are being ignored and mismanaged. The mismanagement also is contributing to the global surge in autism.. In June 2012, Prusiner confirmed that Alzheimers, Parkinsons, Huntingtons and even ALS are prion diseases similar, if not identical, to Creutzfeldt-Jakob disease. The primary difference being which part of the brain the disease attacks first. The other variable is that there are now an unknown number of prion mutations. Mutations of these deadly prions are the common denominator between all forms of TSEs. Most of the carnage is being swept under the rug as the problem escalates.. "There is now real evidence of the potential transmissibility of Alzheimers," says Thomas Wiesniewski M.D. a prion and Alzheimers researcher at New ...
Employment for former prisoners is a critical pathway toward reintegration into society and is central to the processes of desistance from crime. Nevertheless, the economic climate in Western countries has aggravated the ability of former prisoners and people with criminal records to find gainful employment.. After Prison opens with a former prisoners story of reintegration employment experiences. Next, relying on a combination of research interviews, quantitative data, and literature, contributors present an international comparative review of Canadas evolving criminal record legislation; the promotive features of employment; the complex constraints and stigma former prisoners encounter as they seek employment; and the individual and societal benefits of assisting former prisoners attain "gainful" employment. A main theme throughout is the interrelationship between employment and other central conditions necessary for safety and sustenance.. This book offers suggestions for criminal record ...
The enormous costs of mortality and hospitalisation among patients with decompensated chronic heart failure needs to be faced head-on to avoid spiralling healthcare costs, delegates will be warned this morning.. This stark message will form part of the final in-depth session at Heart Failure 2016 looking at key sections of the new ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure, developed with the Heart Failure Association (HFA).. This mornings symposium, which will focus on chronic heart failure and its management, will examine the issues surrounding the management of decompensated chronic heart failure, as well as changes in the management pathway of chronic heart failure patients in general.. Chaired by Gerasimos Filippatos (University of Athens, Greece) alongside Stefan D. Anker (University Medical Center Göttingen, Germany), this mornings session will emphasise the differences between the current recommendations for chronic heart failure and those ...
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor point mutations in ACVR1, a type I receptor for BMPs. Although mutated ACVR1 (FOP-ACVR1) has been shown to render hyperactivity in BMP signaling, we and others have uncovered a mechanism by which FOP-ACVR1 mistransduces BMP signaling in response to Activin-A, a molecule that normally transduces TGF-β signaling. Although Activin-A evokes enhanced chondrogenesis in vitro and heterotopic ossification (HO) in vivo, the underlying mechanisms have yet to be revealed. To this end, we developed a high-throughput screening (HTS) system using FOP patient-derived induced pluripotent stem cells (FOP-iPSCs) to identify pivotal pathways in enhanced chondrogenesis that are initiated by Activin-A. In a screen of 6,809 small-molecule compounds, we identified mTOR signaling as a critical pathway for the aberrant chondrogenesis of ...
Background: Chronic graft-versus-host disease (cGvHD) is the leading cause of late nonrelapse mortality (transplant-related mortality) after hematopoietic stem cell transplant. Given that there are a wide range of treatment options for cGvHD, assessment of the associated costs and efficacy can help clinicians and health care providers allocate health care resources more efficiently. Objective: The purpose of this study was to assess the cost-effectiveness of extracorporeal photopheresis (ECP) compared with rituximab (Rmb) and with imatinib (Imt) in patients with cGvHD at 5 years from the perspective of the Spanish National Health System. Methods: The model assessed the incremental cost-effectiveness/utility ratio of ECP versus Rmb or Imt for 1000 hypothetical patients by using microsimulation cost-effectiveness techniques. Model probabilities were obtained from the literature. Treatment pathways and adverse events were evaluated taking clinical opinion and published reports into consideration. ...
The purpose of this research is to gain insight into the way in which physicians adopt new practice techniques. In particular, we are interested in how medical innovations diffuse throughout social networks. We wish to examine the diffusion of Low Molecular Weight Heparin (LMWH) use for Deep Vein Thrombosis (DVT) throughout the social network of general internal medicine interns, residents, and attendings at the University of Chicago Hospital. In numerous clinical trials, LMWH has been demonstrated to be as effective as unfractionated heparin as a bridge to long-term anticoagulation therapy with Coumadin, with the added benefit of early discharge from the hospital with easy dosing, no need for monitoring, and home therapy. A DVT critical pathway was established at the U of C in 1998, and LMWH was used off-label for that purpose beginning in 1997. However, it is unclear how quickly the use of LMWH was adopted by the physicians on the general medicine services, or whether there exists a pattern ...

Legal TheoryLegal Theory

If you are building a house, you take the reader with you through a pathway into a place where you have a nice entrance, a main ... To quote Bob Scott: Faced with this wide gap between theory and reality, the answers to a critical empirical question remain ... Unless the catcher is in possession of the ball, the catcher cannot block the pathway of the runner as he is attempting to ... A runner attempting to score may not deviate from his direct pathway to the plate in order to initiate contact with the catcher ...
more infohttps://prawfsblawg.blogs.com/prawfsblawg/legal_theory/

Critical PathwaysCritical Pathways

Using Critical Pathways in Clinical Practice. Once completed, a critical pathway stipulates the preferred pattern of service ... A critical pathway can be viewed in CQI terminology as PDCA: Plan Do Check Act. The critical path is the Plan; the clinical ... A critical pathway can begin at any point in the health care delivery continuum. In developing a critical path for cranial base ... Other facilities assign critical pathway development to case managers, or hire outside consultants to develop the pathways. ...
more infohttps://www.asha.org/aud/critical-pathways/

Critical Pathways | AHRQ Patient Safety NetworkCritical Pathways | AHRQ Patient Safety Network

Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ... requiring surgical intervention for critical limb ischemia (including amputation of the contralateral leg above the knee). ...
more infohttps://psnet.ahrq.gov/search?topic=Electronic-health-records&%3Bamp%3Bf_topicIDs=679,503&%3Bamp%3Bf_resource_typeID=212&%3Bf_topicIDs=615&most_recent=true&f_topicIDs=607,102

Critical Pathways | AHRQ Patient Safety NetworkCritical Pathways | AHRQ Patient Safety Network

Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Necessity for a pathway for "high-alert" patients. Get Citation Shane R, Amer K, Noh L, Luong D, Simons S. Am J Health Syst ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ...
more infohttps://psnet.ahrq.gov/search?topic=Education-and-Training&%3Bamp%3Bf_topicIDs=668,603,353,504,216&%3Bf_topicIDs=433&f_topicIDs=607

Critical Pathways in Cardiovascular MedicineCritical Pathways in Cardiovascular Medicine

... cost-effective critical pathways for diagnosis and management of cardiovascular disorders in the pre-hospital setting, ... Critical Pathways in Cardiovascular Medicine, Second Edition presents evidence-based, ... Critical Pathways in Cardiovascular Medicine, Second Edition presents evidence-based, cost-effective critical pathways for ... Critical Pathways in Cardiovascular Medicine. Description. Critical Pathways in Cardiovascular Medicine, Second Edition ...
more infohttps://www.ovid.com/product-details.718.html

Critical pathway - definition of critical pathway by The Free DictionaryCritical pathway - definition of critical pathway by The Free Dictionary

critical pathway synonyms, critical pathway pronunciation, critical pathway translation, English dictionary definition of ... critical pathway. n. 1. A path. 2. Physiology a. A course usually followed by a body part or process. b. A chain of nerve ... Critical pathway - definition of critical pathway by The Free Dictionary https://www.thefreedictionary.com/critical+pathway ... pathway. (redirected from critical pathway). Also found in: Thesaurus, Medical, Legal, Encyclopedia.. Related to critical ...
more infohttps://www.thefreedictionary.com/critical+pathway

Abdominal pain duration critical pathways - wikidocAbdominal pain duration critical pathways - wikidoc

Retrieved from "https://www.wikidoc.org/index.php?title=Abdominal_pain_duration_critical_pathways&oldid=1103216" ...
more infohttps://www.wikidoc.org/index.php/Abdominal_pain_duration_critical_pathways

September 2012 - Volume 11 - Issue 3 : Critical Pathways in CardiologySeptember 2012 - Volume 11 - Issue 3 : Critical Pathways in Cardiology

Thought you might appreciate this item(s) I saw at Critical Pathways in Cardiology.. ... Implementation of a Standardized Pathway for the Treatment of Cardiac Arrest Patients Using Therapeutic Hypothermia: "CODE ICE" ...
more infohttps://journals.lww.com/critpathcardio/toc/2012/09000

September 2019 - Volume 18 - Issue 3 : Critical Pathways in CardiologySeptember 2019 - Volume 18 - Issue 3 : Critical Pathways in Cardiology

Thought you might appreciate this item(s) I saw at Critical Pathways in Cardiology.. ...
more infohttps://journals.lww.com/critpathcardio/toc/2019/09000

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways | Science Translational MedicineOvercoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways | Science Translational Medicine

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ...
more infohttp://stm.sciencemag.org/content/9/413/eaao1214/tab-article-info

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways | Science Translational MedicineOvercoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways | Science Translational Medicine

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ...
more infohttp://stm.sciencemag.org/content/9/413/eaao1214/tab-pdf

Use of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study | CMAJUse of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study | CMAJ

Critical pathways as a strategy for improving care: problems and potential. Ann Intern Med 1995;123:941-8. ... Use of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study. Donald Farquhar ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ...
more infohttps://www.cmaj.ca/content/163/6/755

Evaluation of a critical pathway for stroke  | The Journal of the American Osteopathic AssociationEvaluation of a critical pathway for stroke | The Journal of the American Osteopathic Association

Evaluation of a critical pathway for stroke The Journal of the American Osteopathic Association, May 1997, Vol. 97, 269. doi: ... Evaluation of a critical pathway for stroke You will receive an email whenever this article is corrected, updated, or cited in ... Evaluation of a critical pathway for stroke . J Am Osteopath Assoc 1997;97(5):269. doi: 10.7556/jaoa.1997.97.5.269. ... After the initiation of a critical pathway that begins its interventions in the Emergency Department, the length of stay ...
more infohttp://jaoa.org/article.aspx?articleid=2099217

Critical Pathways to Success in CNS Drug Development, 1st Edition | Clinical Pharmacology & Therapeutics | Pharmacology &...Critical Pathways to Success in CNS Drug Development, 1st Edition | Clinical Pharmacology & Therapeutics | Pharmacology &...

Critical Pathways to Success in CNS Drug Development, 1st Edition. Neal R. Cutler, John J. Sramek, Michael F. Murphy, Henry ... Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS ...
more infohttps://www.wiley.com/en-us/Critical+Pathways+to+Success+in+CNS+Drug+Development%2C+1st+Edition-p-9781444318586

Critical Pathways as a Strategy for Improving Care: Problems and Potential | Annals of Internal Medicine | American College of...Critical Pathways as a Strategy for Improving Care: Problems and Potential | Annals of Internal Medicine | American College of...

... the gaps in our knowledge about critical pathways are extensive; therefore, like any new health care technology, pathway ... Critical Pathways as a Strategy for Improving Care: Problems and Potential Steven D. Pearson, MD, MSc; Dorothy Goulart-Fisher, ... Critical Pathways as a Strategy for Improving Care: Problems and Potential. Ann Intern Med. 1995;123:941-948. doi: 10.7326/0003 ... A Critical Pathway for Management of Patients with Acute Chest Pain Who Are at Low Risk for Myocardial Ischemia: ...
more infohttp://annals.org/aim/article-abstract/709286/critical-pathways-strategy-improving-care-problems-potential

Critical pathway in cell cycle may lead to cancer development - Salk Institute for Biological StudiesCritical pathway in cell cycle may lead to cancer development - Salk Institute for Biological Studies

Critical pathway in cell cycle may lead to cancer development. Salk researchers findings on chromosome shortening suggest a ... Critical pathway in cell cycle may lead to cancer development. Salk researchers findings on chromosome shortening suggest a ... Home - Salk News - Critical pathway in cell cycle may lead to cancer development ... When cells lose the function of p53, the gene at the center of the pathway, they can no longer arrest cells in the G1 phase, an ...
more infohttps://www.salk.edu/news-release/critical-pathway-in-cell-cycle-may-lead-to-cancer-development/

Developing critical pathways for the operating room. - Semantic ScholarDeveloping critical pathways for the operating room. - Semantic Scholar

The critical pathway is an abbreviated version of the patients hospital course according to his or her medical diagnosis or ... The essential tool of managed care systems is a critical pathway, which is developed through the collaboration of health care ... Critical pathway development: an integrative literature review.. *A Harkleroad, D Schirf, J Volpe, M B Holm ... Prevention pathways: application of the critical path methodology in occupational health services.. *Lode Godderis, Kris ...
more infohttps://www.semanticscholar.org/paper/Developing-critical-pathways-for-the-operating-Wieczorek/e59c01ad08d00c9531643aa73006b54e69e7dc71

Contrast-Induced Nephropathy in STEMI Patients With and Without Chronic Kidney Disease, Critical Pathways in Cardiology | 10...Contrast-Induced Nephropathy in STEMI Patients With and Without Chronic Kidney Disease, Critical Pathways in Cardiology | 10...

Critical Pathways in Cardiology" on DeepDyve, the largest online rental service for scholarly research with thousands of ... Add Journal to My Library Critical Pathways in Cardiology , Volume 17 (1) - Mar 1, 2018 ... http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Critical Pathways in Cardiology Wolters Kluwer Health http://www. ...
more infohttps://www.deepdyve.com/lp/wolters_kluwer/contrast-induced-nephropathy-in-stemi-patients-with-and-without-6eElHzjYym

NIH study in mice uncovers pathway critical for UV-induced melanoma | National Institutes of Health (NIH)NIH study in mice uncovers pathway critical for UV-induced melanoma | National Institutes of Health (NIH)

NIH study in mice uncovers pathway critical for UV-induced melanoma. Scientists have made an unanticipated discovery in mice ... "Our findings raise the possibility that targeting the interferon-gamma pathway may represent a novel, less toxic therapeutic ...
more infohttps://www.nih.gov/news-events/news-releases/nih-study-mice-uncovers-pathway-critical-uv-induced-melanoma

Critical Pathways | The Chopra LibraryCritical Pathways | The Chopra Library

The Liverpool Care Pathway for cancer patients dying in hospital medical wards: a before-after cluster phase II trial of ... Care pathways have been developed with the aim of ensuring that dying patients and their family members received by health ... This paper describes the use of a care pathway designed to guide treatment by an integrative group of providers within a ... AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to ...
more infohttp://isharonline.org/tags/critical-pathways

A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use...A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use...

A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ... A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ... A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ...
more infohttp://ebn.bmj.com/content/16/2/48.share

A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use...A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use...

A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ... A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ... A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use ...
more infohttps://ebn.bmj.com/content/16/2/48.info

CCR researchers identify pathway critical for preventing premature aging | Center for Cancer Research - National Cancer...CCR researchers identify pathway critical for preventing premature aging | Center for Cancer Research - National Cancer...

Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T. Repression of the Antioxidant NRF2 Pathway in Premature ... Reactivating the NRF2 pathway, by expressing constitutively active NRF2 (caNRF2) or treating cells with small-molecule NRF2 ... Finally, the scientists tested the effect of the NRF2 pathway on MSCs generated from HGPS patient fibroblasts. Loss of NRF2 in ... Impaired activity of the NRF2 antioxidant pathway is a driver mechanism in Hutchinson-Gilford progeria syndrome (HGPS). ...
more infohttps://ccr.cancer.gov/news/article/nrf2-antioxidant-pathway-critical-for-preventing-premature-aging

Critical Pathway Idiopathic Pulmonary Fibrosis EssayCritical Pathway Idiopathic Pulmonary Fibrosis Essay

Critical Pathway: Idiopathic Pulmonary Fibrosis Essay - Introduction Mr. B is a 65 year old Caucasian male, presenting in the ... Critical pathway idiopathic pulmonary fibrosis essay. This makes failure to recognize and diagnose an underlying condition in a ... Critical Pathway: Idiopathic Pulmonary Fibrosis Essay - Introduction Mr. B is a 65 year old Caucasian male, presenting in the ... Critical pathway idiopathic pulmonary fibrosis essay. Rated 5/5 based on 88 review ...
more infohttps://ryzocyc.kaleiseminari.com/critical-pathway-idiopathic-pulmonary-fibrosis-essay-44420vp.html
  • These pathways combine evidence-based practice parameters with guidelines for the timely completion of specific steps in the process of care. (cmaj.ca)
  • 3 Key components of the pathway included a risk-stratification tool (pneumonia severity index) to guide decision-making about hospital admission, a recommendation to use a single, broad- spectrum antimicrobial agent (levofloxacin, 500 mg once daily) and guidelines for the timing of conversion from intravenous to oral antibiotic therapy and hospital discharge. (cmaj.ca)
  • In an era of increasing competition in medical care, critical pathway guidelines have emerged as one of the most popular new initiatives intended to reduce costs while maintaining or even improving the quality of care.Developed primarily for high-volume hospital diagnoses, critical pathways display goals for patients and provide the corresponding ideal sequence and timing of staff actions for achieving those goals with optimal efficiency. (annals.org)
  • Many hospitals in Canada and the United States have implemented critical pathways (CPs) to reduce variation and control costs in the management of several common conditions. (cmaj.ca)
  • Steps were taken to ensure that treating personnel at the hospitals allocated to conventional management had no knowledge of any of the constituent parts of the critical pathway. (cmaj.ca)
  • Despite the rapid dissemination of critical pathway programs in hospitals throughout the United States, many uncertainties remain about their development, implementation, and evaluation.In addition, serious concerns have been raised about their effect on patient outcomes and satisfaction with care, physician autonomy, malpractice risks, and the teaching and research missions of many hospitals. (annals.org)
  • Reflects new developments including patient-focussed hospitals and critical pathways. (medicalbooks.co.nz)
  • Capitated health plans are embracing critical pathways as a superior way to manage costs and ensure high-quality outcomes for inpatients and outpatients alike. (freethesaurus.com)
  • 1993). Critical paths are a framework for coordinating team work, a route to streamlining health care delivery. (asha.org)
  • Coverage includes new pathways for pre-hospital care, public access defibrillation for cardiac arrest, emergency department management of heart failure and atrial fibrillation, aortic aneurysm, hyperglycemia, peripheral artery disease and claudication, implantable cardioverter defibrillator treatment for ventricular tachycardia, and long-term management of diabetes and the metabolic syndrome. (ovid.com)
  • Critical pathways as a strategy for improving care: problems and potential. (cmaj.ca)
  • Physicians should understand the potential benefits and problems associated with critical pathways because physicians are increasingly being asked to provide leadership for pathway programs.Physicians and other health service investigators should also develop methods to study pathways in evolving health care settings. (annals.org)
  • therefore, like any new health care technology, pathway programs should be fully evaluated in order to understand the conditions under which that promise may be fulfilled. (annals.org)
  • The essential tool of managed care systems is a critical pathway, which is developed through the collaboration of health care team members. (semanticscholar.org)
  • AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to adult cancer patients during their last week of life in hospital. (isharonline.org)
  • SETTINGS/PARTICIPANTS: The trial was performed within four hospital wards participating in the pilot implementation of the Italian version of the Liverpool Care Pathway programme. (isharonline.org)
  • Care pathways have been developed with the aim of ensuring that dying patients and their family members received by health professionals the most appropriate care. (isharonline.org)
  • This review presents and discusses the evidence supporting the effectiveness of the end-of-life care pathways. (isharonline.org)
  • I have been unable to find more recent figures.Our goal is to train future leaders in academic pulmonary and critical care medicine. (kaleiseminari.com)
  • Models and Critical Pathways in Adult Hospital-Based Care. (medicalbooks.co.nz)
  • New developments in care planning will be reflected including critical pathways, and the role of models in Quality Assurance and Audit. (medicalbooks.co.nz)
  • The book will remain practical and critical in style, encouraging a creative response to the use of models in nursing care. (medicalbooks.co.nz)
  • Critical care is now used as a term that encompasses intensive care or intensive therapy provided in intensive care units (ICUs) or intensive therapy units (ITUs), together with what used to be called high-dependency care provided in high-dependency units (HDUs). (nice.org.uk)
  • Recently the distinctions have become blurred, hence the increasing use of the term critical care. (nice.org.uk)
  • Approximately 110,000 people spend time in critical care units in England and Wales each year, the majority surviving to be discharged home. (nice.org.uk)
  • For many, discharge from critical care is the start of an uncertain journey to recovery characterised by, among other problems, weakness, loss of energy and physical difficulties, anxiety, depression, post-traumatic stress (PTS) phenomena and, for some, a loss of mental faculty (termed cognitive function). (nice.org.uk)
  • Consistent with CQI philosophy, pathway development teams must have input from all process stakeholders, so they typically include representatives of the patient population and a variety of caregivers. (asha.org)
  • We measured the overall consistent rankings of these pathways in all four data types. (cdc.gov)
  • To further verify the significance of top 20 EC susceptible pathways, we conducted pathway-level multi-omics analyses using EC exome-Seq, RNA-Seq and survival data, all based on The Cancer Genome Atlas (TCGA) samples. (cdc.gov)
  • Some well-studied pathways, such as p53 signaling and cell cycle pathways, show consistently high rankings across different analyses. (cdc.gov)
  • Using information from consultation with experts and a review of the literature on critical pathways and related quality' improvement methods, we developed a list of pathway characteristics that might be associated with critical pathway effectiveness. (freethesaurus.com)
  • The Salk scientists identified the p53 pathway, a molecular mechanism that normally protects a cell's genetic material and suppresses tumors, as the key player in the response to telomere deprotection. (salk.edu)
  • Impaired activity of the NRF2 antioxidant pathway is a driver mechanism in Hutchinson-Gilford progeria syndrome (HGPS). (cancer.gov)
  • IGF-1/mTOR, rac-1 and IL-5 pathway), genetic information processing pathway (e.g. homologous recombination) and metabolism pathway (e.g. sphingolipid metabolism) are also highly associated with EC risks, diagnosis and prognosis. (cdc.gov)
  • Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. (innovations-report.com)
  • In some facilities members of the existing staff are selected to serve on multidisciplinary teams charged with developing critical paths. (asha.org)
  • The pathway controlling G1-phase growth arrest, however, is commonly altered in cancer cells, allowing cancer cells to divide despite shortened telomeres, which can lead to the genomic instability seen in malignant cells. (salk.edu)
  • Mutations in this important pathway leading to the activation of beta-catenin are responsible for many types of cancer, including colon cancer. (innovations-report.com)
  • We analyzed GWAS data obtained from Connecticut Endometrial Cancer Study (CECS) and identified the top 20 EC susceptible pathways. (cdc.gov)
  • Other facilities assign critical pathway development to case managers, or hire outside consultants to develop the pathways. (asha.org)
  • GSK3 is critical for brain development and neuroplasticity, which appear to be interrelated and to mediate age-associated neurological diseases [ R ]. (selfhacked.com)
  • Finally, the scientists tested the effect of the NRF2 pathway on MSCs generated from HGPS patient fibroblasts. (cancer.gov)
  • The Atlantic Sunrise project is a critical pathway to connect Marcellus production to markets along the Eastern Seaboard, and its timely construction is essential to meeting the market demands for the 2017 heating season," Chief's Senior Vice President of Marketing Andrew Levine wrote in a Feb. (thefreedictionary.com)
  • HRCT is an essential component of the diagnostic pathway in IPF which can identify UIP by the presence of. (kaleiseminari.com)
  • Glycogen synthase kinase 3 (GSK-3 ) is an essential "brake" on many growth-signaling pathways including Wnt and insulin . (selfhacked.com)
  • A critical path can be thought of as a project management plan, or the equivalent of the AAA Trip-Tic, "the most efficient way to reach your destination" (Zander, 1992). (asha.org)
  • When cells lose the function of p53, the gene at the center of the pathway, they can no longer arrest cells in the G1 phase, an important point in the cell cycle for repairing DNA damage or, if the damage cannot be repaired, targeting the cell for programmed death. (salk.edu)
  • Underlying these concerns is the absence of data from controlled trials to evaluate the effects of critical pathways. (annals.org)
  • Inhibitors of GSK3b (in forebrain) are important for reducing anxiety and depression by way of serotonin pathway effects [ R ]. (selfhacked.com)
  • At the George Washington University Medical Center, a multidisciplinary team developed the Joint Replacement Pathway. (asha.org)
  • Because telomere deprotection results in a partial DNA damage response that only arrests cells in G1 through the p53 pathway, once cells lose p53 function telomere deprotection no longer arrests growth. (salk.edu)
  • The Critical Path Method (CPM) was originally developed in the 1950s as a tool for project planning in industrial engineering and managerial sciences. (asha.org)
  • 6 September 2017 Rehabilitation after critical illness in adults (NICE quality standard 158) added. (nice.org.uk)
  • Subsequently, another team was formed for the Craniotomy for Ruptured Aneurysm Pathway. (asha.org)
  • This latter team refined their pathway through the expertise of an outside consultant. (asha.org)
  • The M. D. Anderson-led team made a surprising discovery: Beta-catenin also can travel to the nucleus via activation of the EGFR pathway-and it does so independently of Wnt signaling or mutations. (innovations-report.com)
  • The course offers students a pathway to employment → Ce stage offre aux étudiants un moyen d'entrer dans la vie active . (thefreedictionary.com)
  • Reactivating the NRF2 pathway, by expressing constitutively active NRF2 (caNRF2) or treating cells with small-molecule NRF2 activators, including FDA-approved Oltipraz, rescued most HGPS cellular defects, as did treating HGPS cells with the general antioxidant N-acetyl cysteine. (cancer.gov)