Critical Pathways
Hospital Costs
The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).
Utilization Review
Efficiency, Organizational
Hospitals, University
Postoperative Care
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Postoperative Complications
alpha Catenin
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Cytoskeletal Proteins
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Memory
Fear
Conditioning, Classical
Neuronal Plasticity
Amygdala
Extinction, Psychological
Experience with a managed care approach to HIV infection: effectiveness of an interdisciplinary team. (1/353)
To evaluate the function and effectiveness of a multidisciplinary team for managing human immunodeficiency virus (HIV) infection, we conducted a follow-up cohort study of HIV-positive patients managed according to a clinical care path at a staff-based health maintenance organization (HMO). The study group consisted of 230 HIV-positive health plan members who received care at the Kaiser Permanente Santa Rosa medical center (KPMC-SRO). In 1994, the comparison group consisted of 4747 HIV-positive health plan members who received care at Kaiser Permanente's 18 other medical centers in northern California. The percentages of acquired immunodeficiency syndrome (AIDS) and HIV-positive patients as determined by CD4+ T-cell counts were similar (P = 0.97). Compared with patients at the other Kaiser Permanente medical centers, KPMC-SRO patients had more visits with nurse practitioners (rate ratio [RR] = 1.72) and nutritionists (RR = 12.3) and fewer visits with primary care physicians (RR = 0.82). More HIV-positive members at KPMC-SRO received social workers' services (27% at KPMC-SRO vs 6% for patients at the other Kaiser Permanente medical centers) and fewer used emergency services (RR = 0.92) and psychiatric services (RR = .89). At KPMC-SRO, the mean number of days that AIDS patients spent in the hospital decreased from 7.8 (1991) to 2.01 (1994). Hospital admissions were fewer (AIDS patients, RR = 0.67; HIV-positive patients without AIDS, RR = 0.45), and length of stay was briefer, compared with patients at the other Kaiser Permanente Medical Centers. The mean cost of HIV-related drugs for patients seen at KPMC-SRO ($2343 per infected member) was lower than that for patients seen elsewhere in the region ($3289 per infected member). These results suggest that in an HMO setting, managed care provided by a dedicated interdisciplinary team according to a clinical care path can substantially and favorably affect resource use. (+info)The development and implementation of normal vaginal delivery clinical pathways in a large multihospital health system. (2/353)
The entire country has become more concerned with healthcare costs due to managed care, capitation risk-based contracts, and the near elimination of the cost-plus reimbursement system. Clinical pathways have become one way to reduce unnecessary resource consumption by reducing provider variance, improving clinical outcomes, and reducing cost. We present here our rationale and process for developing a common clinical pathway for normal vaginal delivery in a large and varied multihospital system. We also discuss how this new pathway is expected to improve quality of care and reduce costs. (+info)Influence of a critical path management tool in the treatment of acute myocardial infarction. Clinical Quality Improvement Network Investigators. (3/353)
OBJECTIVE: The primary objective of this study was to determine the effect of implementing a critical path on use of proven efficacious therapies and outcomes in patients admitted to a hospital with acute myocardial infarction (AMI). The secondary objectives were to evaluate the use of unproven medications and to develop an understanding of the factors associated with adverse in-hospital outcomes in these patients. STUDY DESIGN: A nonrandomized before-after study design was used to evaluate the efficacy of a critical path instrument in patients admitted to hospital with AMI. PATIENTS AND METHODS: Consecutive patients admitted with AMI in nine participating hospitals were enrolled in the study. The critical path instrument consisted of a locally developed, preprinted physician order form. Practice patterns were determined before (n = 2305) and after (n = 2349) implementation of the critical path by primary chart review. Multivariate analysis of risk factors for mortality was performed on a combined database of 6088 AMI patients. RESULTS: The use of acetylsalicylic acid (ASA), nitrates, and beta blockers increased significantly by 3%, 2%, and 9%, respectively, after implementation of the critical path. Use of thrombolytics remained stable at 41%, and calcium channel blocker use decreased significantly by 8%. In-hospital mortality decreased by 1%. There was less use of ASA, nitrates, beta blockers, and thrombolytic therapy in women and the elderly. Multivariate analysis showed that advanced age was associated with increased mortality risk, whereas ASA, beta blockers, nitrates, and calcium channel blockers were associated with reduced mortality risk. CONCLUSION: Implementation of a critical path resulted in increased use of proven efficacious therapies, reduced use of noneffective therapy, and a trend toward reduced mortality. (+info)Evaluating and improving the delivery of heart care: the University of Michigan experience. (4/353)
With increasing pressure to curb escalating costs in medical care, there is particular emphasis on the delivery of cardiovascular services, which account for a substantial portion of the current healthcare dollar spent in the United States. A variety of tools were used to improve performance at the University of Michigan Health System, one of the oldest university-affiliated hospitals in the United States. The tools included initiatives to understand outcomes after coronary bypass operations and coronary angioplasty through use of proper risk-adjusted models. Critical pathways and guidelines were implemented to streamline care and improve quality in interventional cardiology, management of myocardial infarction, and preoperative assessment of patients undergoing vascular operations. Strategies to curb unnecessary costs included competitive bidding of vendors for expensive cardiac commodities, pharmacy cost reductions, and changes in nursing staff. Methods were instituted to improve guest services and partnerships with the community in disease prevention and health promotion. (+info)Infrarenal aortic surgery with a 3-day hospital stay: A report on success with a clinical pathway. (5/353)
PURPOSE: This paper reports on an experience with a clinical pathway for elective infrarenal aortic surgery (AS) that targeted hospital discharge on postoperative day (POD) 3. The pathway incorporated early feeding, early ambulation, and selective use of the intensive care unit (ICU). METHODS: A review of 50 consecutive hospital discharges after AS (aneurysm repair and aortofemoral bypass grafting) by a single surgeon performed from April 1996 through June 1998 with this clinical pathway is reported. The data collected included morbidity rate, mortality rate, length of stay (LOS), and number of hospital readmissions. RESULTS: The average LOS for all patients was 3.0 days. Only six patients (12%) were admitted to the ICU. Discharge on POD 3 was achieved in 80% of the group (40 of 50), and increasing experience improved compliance, with 92% of the most recent 25 patients (23 of 25) being discharged by POD 3. Eleven of these 25 patients (44%) were discharged on POD 2. No patient was readmitted to the hospital within a 30-day period after discharge. There was no mortality after AS during this period. CONCLUSION: Factors that limit the discharge of patients recovering from AS include the ability to ambulate independently and to tolerate a diet. Ambulation and feeding on POD 1 were well tolerated by most patients, which shortened the period of hospitalization. Admission to the ICU was infrequently required when a monitored surgical step-down unit was available. Discharge by POD 3 for AS has been proven to be routinely achievable, safe, and well accepted by patients and to reduce the cost of hospitalization. (+info)The role of clinical practice guidelines in disease management. (6/353)
This activity is designed for medical directors, pharmacy directors, quality assurance managers, and all members of disease management or quality improvement teams. GOAL: To review the guideline literature and help healthcare organizations plan guideline development and implementation strategies. OBJECTIVES: 1. Clarify the terminology used in practice policy development. 2. Explain how guideline implementation is related to disease management. 3. Discuss interventions utilized to enhance guideline adoption. 4. Provide a stepwise plan for healthcare organizations to follow. (+info)New picture archiving and communications system plus new facility equals critical path planning challenge. (7/353)
The architectural design and construction of a new imaging department is one of the most complex challenges in healthcare architecture. When a client also plans a simultaneous change in basic operating system technology from film-based to filmless imaging, the challenge for both hospital management and the facility/technology design team is even more complicated. A purposeful planning process plus a carefully composed team of internal and external experts are the two essentials for success in executing this difficult conversion of both facility and technology. (+info)A community hospital-based congestive heart failure program: impact on length of stay, admission and readmission rates, and cost. (8/353)
OBJECTIVE: To do an analysis of patients with a primary diagnosis of congestive heart failure at discharge before (n = 407) and after (n = 347) the implementation of a comprehensive inpatient and outpatient congestive heart failure program consistent with the guidelines of the Agency for Health Care Policy and Research. STUDY DESIGN: A retrospective analysis of the impact of the congestive heart failure program on length of stay, admission and readmission rates, and costs to both patient and provider. The program, which used a multidisciplinary team approach, included an intensive education program focusing on diet, compliance, and symptom recognition, as well as the use of outpatient infusions. It also incorporated aggressive pharmacologic treatment for patients with advanced congestive heart failure. RESULTS: Our analysis revealed significant decreases in length of stay, admission and readmission rates, and costs to the patient and provider (P < or = .05). The mean cost per admission decreased 17% ($1118), and a substantial 77% ($718,468) net reduction in nonreimbursed (lost) hospital revenue was noted. CONCLUSION: A multidisciplinary, comprehensive congestive heart failure program can improve patient care in a community-hospital setting while significantly reducing costs to both the patient and the institution. (+info)
Critical pathway synonyms, critical pathway antonyms - FreeThesaurus.com
Shop Clinical Pathways In Emergency Medicine: Volume I 2016
Clinical Pathway Implementation and Teamwork in Swedish Intensive Care : Challenges in Evidence-Based Practice and...
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 ...
ASCO Releases Criteria for High-Quality Clinical Pathways in Oncology - The ASCO Post
Treatment pathways, resource use, and costs of endovascular coiling versus surgical clipping after aSAH. - Nuffield Department...
Clinical pathway legal definition of clinical pathway
Describing the characteristics, treatment pathways, outcomes, and cost | JMDH
PCDS psoriasis treatment pathway guideline | Independent professional body guideline | Guidelines
PCDS psoriasis treatment pathway guideline | Independent professional body guideline | Guidelines
AIM Cancer Treatment Pathways & Guidelines | AIM Specialty Health
A Treatment Pathway for High Security Offenders with a Personality Disorder - Working Positively with Personality Disorder in...
Effect of a clinical pathway on the hospitalisation rates of children with asthma: a prospective study | Archives of Disease in...
A clinical pathway reduced length of stay, time to ambulation, and complications after hip and knee arthroplasty | Evidence...
Clinical pathways as a healthcare tool: design, implementation and assessment of a clinical pathway for lower-extremity deep...
BCB Medical: Pioneering information systems to the health care sector - Scanbalt
Implementation of a clinical pathway decreases length of stay and hospital charges for patients undergoing total colectomy and...
Download Clinical Guidelines in Urological Management by Kieran J. OFlynn (auth.), Shinichi Ohshima M.D., Ph.D., PDF -...
Patent US6230142 - Health care data manipulation and analysis system - Google Patents
Critical Pathways | The Chopra Library
September 2019 - Volume 18 - Issue 3 : Critical Pathways in Cardiology
March 2014 - Volume 13 - Issue 1 : Critical Pathways in Cardiology
Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma ...
MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION...
The modulation of the COX process by NO represents an critical pathway that regulates the magnitude of the inflammatory method ...
Substance use outcomes following treatment : findings from the Australian Patient Pathways Study - Sheffield Hallam University...
Clinical Pathways is Medical Education
Clinical Pathways | Moffitt
SAT0304 Long-Term Costs of Biologics in the Treatment of Psoriatic Arthritis in the United States | Annals of the Rheumatic...
Cancer treatment pathways: AML a detailed costing study example - White Rose eTheses Online
Characterizing treatment pathways at scale using the OHDSI network. | U.S. National Library of Medicine
2017 August Archive - Neurosurgery Blog
Brevet US20080036339 - Network Cabinet - Google Brevets
Factors affecting the implementation process of clinical pathways : A mixed method study within the context of Swedish...
PhRMA Principles on Clinical Pathway Programs | PhRMA
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GPCRs, Desirable Therapeutic Targets in Oncology - Drug Discovery and Development
Vascular Cures Research Network - Vascular Cures
Welcome - Aparna Lakkaraju Lab - UCSF Department of Ophthalmology
Synapse - Art Science Collaborations
Toxics | Free Full-Text | Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development
Kitaplar
The genomic landscape of cutaneous melanoma
Substance use outcomes following treatment: Findings from the Australian Patient Pathways Study
Shared decision making in standardized cancer patient pathways in Norway - patient experiences - SINTEF
Analysis of a Clinical Pathway for Elective Gastrectomy | OncologyPRO
A three-step critical pathway for community-acquired pneumonia reduces duration of hospital stay and intravenous antibiotic use...
Innovations in Chronic Care Delivery Using Data-Driven Clinical Pathways
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Changes to services and referral pathways for SJOG Midland Physician Services - WAPHA
An emergency clinical pathway for stroke patients - results of a cluster randomised trial (isrctn41456865) | BMC Health...
Non-Traumatic Scrotal/Testicular Pain Clinical Pathway - Emergency Department | Childrens Hospital of Philadelphia
The Complete Denture: A Clinical Pathway,2014
Mutations in gene promoters reveal specific pathway pathologies in pancreatic cancer - Scienmag: Latest Science and Health News
Department of Pathology - Researchers Find New Target to Improve Response to Cancer Immunotherapy
Researchers identify brain pathway linked with cocaine addiction | Addiction Professional Magazine
Michael Hayden - Bioinformatics grad studies at UBC and SFU
Apigenin Demonstrates Great Promise As A Natural Molecule for Cancer Prevention - BioFoundations
How to Become a Control Freak | Science Signaling
Scientists Uncover Process Enabling Toxoplasmosis Parasite to Survive Homelessness
Orthoptics - Stroke Patient Pathway
Events | LiDCO - Hemodynamic Monitoring for the entire patient pathway
Mental Health and Behavior Change - Gede Foundation
JAMA Oncology Author Interviews: Covering research, science, & clinical practice in oncology that improves the care of patients...
Endometriosis
County Durham and Darlington Formulary
AACR Journals Editors Picks for August - American Association for Cancer Research (AACR)
Pathways Have the Potential to Deliver Personalized Medicine | Value-Based Cancer Care
Anti-malaria drugs have shown promise in trea | EurekAlert!
Gender differences in the treatment of patients with acute myocardial ischemia and infarction in england. | Base documentaire ...
PDF] Gluten Related Disorders: Diagnostic approaches, Treatment Path
Basal & squamous cell carcinoma treatment | ONJ Cancer Centre
Heparínom indukovaná trombocytopénia a aktuálne možnosti liečby - prehľad literatúry | proLékaře.cz
Pulse-Echo Ultrasound Useful for Osteoporosis Screening - The Rheumatologist
MRP Kidney Disease Referral Pathway
Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs - Rotter - 2010 - The...
Prostate Cancer Active Surveillance Increasing, But Still Low | Journal Of Clinical Pathways
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remedy pathway
Mrs Amanda Donkin
Patient care
Apollo Hospitals to launch 100 Sugar Clinics in the next 90 days !
Only Trust Will Make the Future Model of Care Work - Pritpal S Tamber
Not Running a Hospital: February 2007
Not Running a Hospital: February 2007
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Neutropenia Guidelines - GHNHSFT
Lorna Breen
Critical Pathways in Cardiology. 18 (4): 167-175. doi:10.1097/HPC.0000000000000189. PMID 31725507. "A Doctor's Emergency". ... "An Updated Healthcare System-Wide Clinical Pathway for Managing Patients With Chest Pain and Acute Coronary Syndromes". ...
Obesity paradox
Critical Pathways in Cardiology. 5 (4): 187-90. doi:10.1097/01.hpc.0000249784.29151.54. PMID 18340236. Pearson, T. A. (2007). " ...
Axonotmesis
Critical Pathways in Therapeutic Intervention. Missouri: Mosby Inc. p. 262. ISBN 0-323-00105-X. "Nerve Injury (Neuropraxia, ...
Saturated fat
Cannon, Christopher; O'Gara, Patrick (2007). Critical Pathways in Cardiovascular Medicine, 2nd Edition. Lippincott Williams & ... There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity ...
Saturated fat
Cannon C, O'Gara P (2007). Critical Pathways in Cardiovascular Medicine (2nd ed.). Lippincott Williams & Wilkins. p. 243.. ... There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity ...
Peripartum cardiomyopathy
Critical Pathways in Cardiology (10): 44-45. "UOTW #14 - Ultrasound of the Week". Ultrasound of the Week. 20 August 2014. ...
English as a second or foreign language
Pathways Listening, Speaking, and Critical Thinking by MacIntyre. Douglas, Scott R. Academic Inquiry: Writing for Post- ... Robert Lowth (26 March 1794). A Short Introduction to English Grammar: With Critical Notes. Printed for J.J . Tourneisin - via ...
Nir Barzilai
Barzilai, N; Huffman, DM; Muzumdar, RH; Bartke, A (June 2012). "The critical role of metabolic pathways in aging". Diabetes. 61 ... 2018). "Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older ... "Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans". PLoS Biol. 4 (4): e113. doi:10.1371/journal. ...
Cortico-basal ganglia-thalamo-cortical loop
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The second pathway, is called the direct (or Go) pathway and is excitatory. This pathway inhibits the GPi, resulting in the ... Two pathways emerge from the striatum. One pathway is called the indirect (or NoGo) pathway and is inhibitory. This projects to ... As of 2013 there was intense debate with regards to division of the circuit, pathway interactions, number of pathways and ...
Basal ganglia
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The motor and oculomotor pathways are sometimes grouped into one motor pathway.) The five general pathways are organized as ... The short indirect pathway has been proposed to, in a direct push pull antagonism with the direct pathway, close the gate to ... However the speed of the direct pathway would not be concordant with the indirect pathway in this model leading to problems ...
Medium spiny neuron
The indirect pathway also receives excitatory input from various brain regions. Indirect pathway medium spiny neurons project ... Dopamine plays critical roles in the regulation of psychomotor functions in the brain (Bromberg-Martin et al., 2010; Cools, ... However, direct pathway medium spiny neurons mostly signal sequence initiation/termination and indirect pathway medium spiny ... D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. Most striatal MSNs contain only D1-type or D2-type ...
Claude Raffestin
Juliet J. Fall: Reading Claude Raffestin: pathways for a critical biography. In: Environment and Planning D: Society and Space ...
Nate Smith (musician)
Smith appears on the albums Critical Mass (2005) and Pathways (2009). In 2017, he released his first album as leader, Kinfolk: ... 1 (ArtistShare, 2014) More Than Meets the Ear (ArtistShare, 2015) With Dave Holland Critical Mass (Dare2, 2006) Pathways (Dare2 ...
Messenger RNA decapping
A number of specific decay pathways exist that recognize aberrant messages and promote their decapping. Nonsense mediated decay ... Critical Reviews in Biochemistry and Molecular Biology. 39 (4): 197-216. doi:10.1080/10409230490513991. PMID 15596551. Deana, ... Meyer, Sylke; Temme, Claudia; Wahle, Elmar (January 2004). "Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes". ...
Binding site
Hence binding site on protein are critical parts of signal transduction pathways. Types of ligands include neurotransmitters, ... Its regulation in glycolysis is imperative because it is the committing and rate limiting step of the pathway. PFK also ... This regulation efficiently conserves glucose reserves, which may be needed for other pathways. Citrate, an intermediate of the ... Binding sites incur functional changes in a number of contexts, including enzyme catalysis, molecular pathway signaling, ...
Fundic gland polyposis
Chung, DC (2000). "The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis". Gastroenterology ... Both the β-catenin gene and the APC gene are involved in the same cell growth signalling pathway, but the APC gene is known to ...
Orofaciodigital syndrome 1
Cilia defects adversely affect numerous critical developmental signaling pathways essential to cellular development. Other ...
Religion and health
A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066X.58.1.53 ... A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066x.58.1.53 ... Evidence suggests that religiosity can be a pathway to both mental health and mental disorder. For example, religiosity is ...
MTORC2
"A critical role for the mTORC2 pathway in lung fibrosis". PLOS ONE. 9 (8): e106155. Bibcode:2014PLoSO...9j6155C. doi:10.1371/ ... The mTORC2 pathways plays a crucial role in pathogenesis of lung fibrosis , and inhibitors of its active site such as ... Studies using mice with tissue-specific loss of Rictor, and thus inactive mTORC2, have found that mTORC2 plays a critical role ... Mendoza MC, Er EE, Blenis J (June 2011). "The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation". Trends in ...
Farnesyl-diphosphate farnesyltransferase
... a critical enzyme in the cholesterol biosynthesis pathway". Clin. Genet. 75 (1): 19-29. doi:10.1111/j.1399-0004.2008.01099.x. ... Statin Pathway edit]] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". Squalene synthase (SQS ... FPP is an important metabolic intermediate in the mevalonate pathway that represents a major branch point in terpenoid pathways ... A tyrosine residue (Tyr-171) plays a critical role in this step by serving as a proton donor to facilitate abstraction of ...
Zaragozic acid
... a critical enzyme in the cholesterol biosynthesis pathway". Clin. Genet. 75 (1): 19-29. doi:10.1111/j.1399-0004.2008.01099.x. ... The core biosynthetic route is via a polyketide synthase pathway from 10 acetates, 4 methyls of methionines, 1 succinate, and 1 ...
포화 지방산 - 위키백과, 우리 모두의 백과사전
Cannon C, O'Gara P (2007). 》Critical Pathways in Cardiovascular Medicine》 2판. Lippincott Williams & Wilkins. 243쪽.. ...
Ciliopathy
A number of critical developmental signaling pathways essential to cellular development have been discovered. These are ... Signal transduction pathways involved include the Hedgehog signaling pathway and the Wnt signaling pathway. Dysfunctional cilia ... Cilia may thus be "viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes ... cilia are critical for: development homeostasis reproduction "Just as different genes can contribute to similar diseases, so ...
Marden-Walker syndrome
The cilia defects adversely affect "numerous critical developmental signaling pathways" essential to cellular development. The ...
Vascular endothelial growth factor C
A critical role of p38/nuclear factor-kappa B signaling pathway". The Journal of Biological Chemistry. 278 (8): 5750-9. doi: ...
Pulvinar nuclei
Mundinano, Inaki (2018). "Transient visual pathway critical for normal development of primate grasping behavior". Proceedings ... Berman R.; Wurtz R. (2011). "Signals conveyed in the pulvinar pathway from superior colliculus to cortical area mt". The ...
Testicular receptor 4
"TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway". Journal of Molecular Biology. 326 (1): 105- ... Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 ... a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United ... a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United ...
Chloramination
A Critical Review of Nitrogenous Disinfection Byproduct Formation Pathways". Environmental Science & Technology. 46 (1): 119- ...
Epigenetics
The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well ... In 2011, it was demonstrated that the methylation of mRNA plays a critical role in human energy homeostasis. The obesity- ... These newly constructed networks function very efficiently via new pathways as soon as drugs of abuse are further taken ... In ... In the original sense of this definition, epigenetics referred to all molecular pathways modulating the expression of a ...
Urotensin-II receptor
This meant that it affected the activation of both pathways and plays a critical role. The other two amino acids which were ... Y1493.50 still activated both PKC and ERK1/2 suggesting that they did not play a critical role in the activation of the pathway ... The receptor cannot activate the PKC but it can still activate the ERK1/2 pathway although it is a little bit slower. There ... The mutated D972.50 receptor could not activate PKC nor could it activate the ERK1/2 pathway. ...
Bile acid
Minor pathways initiated by 25-hydroxylase in the liver and 24-hydroxylase in the brain also may contribute to bile acid ... "Critical micellar concentration" refers to both an intrinsic property of the bile acid itself and amount of bile acid necessary ... An alternative (acidic) pathway of bile acid synthesis is initiated by mitochondrial sterol 27-hydroxylase (CYP27A1), expressed ... The initial step in the classical pathway of hepatic synthesis of bile acids is the enzymatic addition of a 7α hydroxyl group ...
Muscle atrophy
Therefore, one way in which not exercise induces an increase in muscle mass is to down regulate the pathways which have the ... The branched-chain amino acids or BCAAs (leucine, isoleucine, and valine) are critical to this process, in addition to lysine ... The particular protein degradation pathway which seems to be responsible for much of the muscle loss seen in a muscle ... Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - ...
Positron emission tomography
PET technology can be used to trace the biologic pathway of any compound in living humans (and many other species as well), ... Laruelle, M (2000). "Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review". ...
Ebola
"First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health ... dysfunctional bleeding and clotting commonly seen in EVD has been attributed to increased activation of the extrinsic pathway ...
Pre-Bötzinger complex
Synaptic inhibition is critical for allowing the pre-Bötzinger complex to communicate with other respiratory centers in order ... or inhibit the NALCN channels depending on the neurotransmitter that binds the receptor and the specific signaling pathway that ... Serotonin plays a critical role in altering the pacemaker neurons involved in gasping and normal respiratory activity. Blocking ... The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs ...
Substance P
Different emetic pathways exist, and substance P/NK1R appears to be within the final common pathway to regulate vomiting.[36] ... "American Journal of Respiratory and Critical Care Medicine. 163 (3 Pt 2): S18-21. doi:10.1164/ajrccm.163.supplement_1.2011113. ... Because these regions are related to complexed signal transduction pathways mediated by cytokines, it has been proposed that ... "Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor". Molecular Biology of the ...
Kenzō Tange
The zones were interconnected with moving pathways.[27] Architectural circle[edit]. Congrès International d'Architecture ... Frampton, Kenneth (1990) [1980]. Modern Architecture a Critical History (Revised and enlarged ed.). London, United Kingdom: ...
Osteochondroprogenitor cell
β-catenin of the canonical Wnt signalling pathway plays a role in cell fate determination, as it is critical for ... Knock out of the entire pathway results in early embryonic death, therefore most research of this nature utilised conditional ... Loss of the regulator, Pten, of the Phophatidylinositol3' kinase pathway results in skeletal overgrowth and growth plate ... However the exact mechanism and signalling pathways are still unclear. Studies have shown that embryonic stem cells are more ...
Medicine
... neurotransmitter pathway, metabolic pathway, blood flow, or other), and a radionuclide (usually either a gamma-emitter or a ... and some are specialized in critical medicine. ...
Lyme disease
Bolz DD, Weis JJ (August 2004). "Molecular mimicry to Borrelia burgdorferi: pathway to autoimmunity?". Autoimmunity. 37 (5): ... "A critical appraisal of "chronic Lyme disease"". The New England Journal of Medicine. 357 (14): 1422-30. doi:10.1056/ ... "Critical evaluation of the linkage between tick-based risk measures and the occurrence of Lyme disease cases". J Med Entomol ... resistance of a genospecies of Lyme disease spirochetes to the bacteriolytic activities of the alternative complement pathway ...
Alkali metal
El Murr, N.; Sheats, J. E.; Geiger, W. E.; Holloway, J. D. L. (1979). "Electrochemical Reduction Pathways of the Rhodocenium ... The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle ...
Occupational health psychology
... rewards triggers high levels of activation in neurohormonal pathways that, cumulatively, are thought to exert adverse effects ...
Cold fusion
In July and November 1989, Nature published papers critical of cold fusion claims.[55][56] Negative results were also published ... Only about one in one million of the intermediaries decay along the third pathway, making its products comparatively rare when ... Mostly in the 1990s, several books were published that were critical of cold fusion research methods and the conduct of cold ... The products formed via these decay pathways are:. 4He* → n + 3He + 3.3 MeV (ratio=50%). 4He* → p + 3H + 4.0 MeV (ratio=50%). 4 ...
Whale
"North Atlantic Right Whale Source Document for the Critical Habitat Designation: A review of information pertaining to the ... Cranford, T.W.; Krysl, P.; Hildebrand, J.A. (2008). "Acoustic pathways revealed: simulated sound transmission and reception in ... definition of "critical habitat"". NOAA Fisheries. July 2014.. *. Laidre, K. L.; Stirling, I.; Lowry, L. F.; Wiig, Ø.; Heide- ...
Philip Nitschke
Organisations opposed to euthanasia,[14][15] as well as some supporting euthanasia, are critical of Nitschke and his methods.[ ... he posed a serious risk because people may elect to commit suicide believing it to be a pathway sanctioned by a medical ...
PSEN1
Wnt signaling pathway[edit]. Wnt signaling pathway has been shown to be involved in several critical steps in embryogenesis and ... Notch signaling pathway[edit]. In Notch signaling, critical proteolytic reactions takes place during maturation and activation ... These evidences collectively suggest a critical role of presenilin 1 in the Notch signaling pathway. ... canonical Wnt signaling pathway. • dorsal/ventral neural tube patterning. • neural retina development. • positive regulation of ...
Hypothalamic-pituitary-adrenal axis
The CNS regulates the immune system through neuroendocrine pathways, such as the HPA axis. The HPA axis is responsible for ... There may be a critical period during development during which the level of stress hormones in the bloodstream contribute to ... Macrì S, Würbel H (December 2006). "Developmental plasticity of HPA and fear responses in rats: a critical review of the ... Maintenance of the SHRP period may be critical for HPA development, and the extreme stress of maternal separation, which ...
RAD51
The breast cancer susceptibility protein BRCA2 and PALB2 controls the function of Rad51 in the pathway for DNA repair by ... "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment". Proceedings of ... by the HRR RAD52-RAD51 back-up pathway[14]) to compensate for the added DNA damages remaining when BRCA1 was deficient.[12][13] ... "Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer ...
Bioarchaeology
The different photosynthesis pathways used by C3 and C4 plants cause them to discriminate differently towards 13C The C4 and C3 ... Some archaeologists advocate a more holistic approach to bioarchaeology that incorporates critical theory and is more relevant ... The three photosynthesis pathways are C3 carbon fixation, C4 carbon fixation and Crassulacean acid metabolism. C4 plants are ... Corn, millet and sugar cane are some well-known C4 domesticates, while all trees and shrubs use the C3 pathway. C3 plants are ...
Economics
... uses of test statistics are themselves open to critical analysis,[161] although critical commentary on papers in economics in ... Towards a Green Economy: Pathways to Sustainable Development and Poverty Eradication (PDF) (Report). United Nations Environment ... Hunt, E. K. (2002). History of Economic Thought: A Critical Perspective. M.E. Sharpe. p. 36. ISBN 978-0-7656-0606-8. .. ... Adam Smith (1723-1790) was an early economic theorist.[37] Smith was harshly critical of the mercantilists but described the ...
Archaea
A fifth pathway of carbon fixation". Science. 318 (5857): 1732-3. doi:10.1126/science.1152209. PMID 18079388.. ... Methanogens also play a critical role in the carbon cycle, breaking down organic carbon into methane, which is also a major ... Romano A; Conway T (1996). "Evolution of carbohydrate metabolic pathways". Res Microbiol. 147 (6-7): 448-55. doi:10.1016/0923- ... Most of the metabolic pathways, which are the object of the majority of an organism's genes, are common between Archaea and ...
Feminist theology
Anderson, Pamela Sue; Clack, Beverley (eds.) Feminist Philosophy of Religion: Critical Readings (London: Routledge, 2004) ISBN ...
Histone
H3K36me3 has the ability to recruit the MSH2-MSH6 (hMutSα) complex of the DNA mismatch repair pathway.[96] Consistently, ... Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM (2000). "A critical role for histone H2AX in ... "A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin". Genes & Development. 18 (11): ...
Biofuel
Multiple pathways for the conversion of different biofuel feedstocks are being used. In the next few years, the cost data of ... The selection of land on which to grow the feedstocks is a critical component of the ability of biofuels to deliver sustainable ...
Altruism
... they showed that both pure monetary rewards and charitable donations activated the mesolimbic reward pathway, a primitive part ... Critical rationalism. *Experimental philosophy. *Falsificationism. *Foundationalism / Coherentism. *Generative linguistics. * ...
Cerebral hypoxia
at the American Association of Critical-Care Nurses website. *^ Orozco-Gutierrez A, Rojas-Cerda L, Estrada RM, Gil-Rosales C ( ... Nov 2001). "Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose". ... Critical Care Medicine. 31 (3): 960-7. doi:10.1097/01.ccm.0000053643.21751.3b. PMID 12627012.. ...
Myers-Briggs Type Indicator
Language learning motivation: pathways to the new century (Google Book). Retrieved 2012-01-27.. ... Dawes, Robyn (2004). "Time for a critical empirical investigation of the MBTI: Case and Phillipson are right to highlight the ... Supporters of the "projective" approach to personality assessment are critical of the "structured" approach because defense ... It has been argued that this reflects a lack of critical scrutiny.[40] Many of the studies that endorse MBTI are ...
Glycogen phosphorylase
Newgard CB, Hwang PK, Fletterick RJ (1989). "The family of glycogen phosphorylases: structure and function". Critical Reviews ... metabolic pathway. PRIAM. profile. PDB structures. RCSB PDB PDBe PDBsum. Gene Ontology. AmiGO / QuickGO. ...
Peroxisome
... ether phospholipids critical for the normal function of mammalian brains and lungs.[4] They also contain approximately 10% of ... "A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defense". Science. 323 (5910): 101- ... and the NADP-dehydrogenases of the pentose-phosphate pathway. It has been demonstrated that peroxisomes generate superoxide (O2 ... the total activity of two enzymes in the pentose phosphate pathway, which is important for energy metabolism.[4] It is ...
Race condition
Critical and non-critical forms[edit]. A critical race condition occurs when the order in which internal variables are changed ... "Canceling actions involves a race between basal ganglia pathways". Nature Neuroscience. 16 (8): 1118-24. doi:10.1038/nn.3456 ... Life-critical systems[edit]. Software flaws in life-critical systems can be disastrous. Race conditions were among the flaws in ... Critical race conditions cause invalid execution and software bugs. Critical race conditions often happen when the processes or ...
Critical Pathways
Using Critical Pathways in Clinical Practice. Once completed, a critical pathway stipulates the preferred pattern of service ... A critical pathway can be viewed in CQI terminology as PDCA: Plan Do Check Act. The critical path is the Plan; the clinical ... A critical pathway can begin at any point in the health care delivery continuum. In developing a critical path for cranial base ... Other facilities assign critical pathway development to case managers, or hire outside consultants to develop the pathways. ...
Critical Pathways in Cardiology
Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] ...
Critical Pathways | AHRQ Patient Safety Network
Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ... requiring surgical intervention for critical limb ischemia (including amputation of the contralateral leg above the knee). ...
Critical Pathways | AHRQ Patient Safety Network
Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Necessity for a pathway for "high-alert" patients. Get Citation Shane R, Amer K, Noh L, Luong D, Simons S. Am J Health Syst ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ...
Evidence-Based Guidelines and Critical Pathways for Quality Improvement | American Academy of Pediatrics
Critical pathway - definition of critical pathway by The Free Dictionary
critical pathway synonyms, critical pathway pronunciation, critical pathway translation, English dictionary definition of ... critical pathway. n. 1. A path. 2. Physiology a. A course usually followed by a body part or process. b. A chain of nerve ... Critical pathway - definition of critical pathway by The Free Dictionary https://www.thefreedictionary.com/critical+pathway ... pathway. (redirected from critical pathway). Also found in: Thesaurus, Medical, Legal, Encyclopedia.. Related to critical ...
STING Pathway Plays Critical Role in Immunocancer Therapy
... November 21, 2014. 0 ... Detection of such "cytosolic" DNA initiates a series of interactions that lead to the STING pathway. Activating the pathway ... "Our results demonstrate that a major mechanism for innate immune sensing of cancer occurs via the host STING pathway, with ... Understanding the role of the STING pathway provides insights into how we can wake up the immune response against tumors. ...
Critical Pathways in Cardiovascular Medicine
... cost-effective critical pathways for diagnosis and management of cardiovascular disorders in the pre-hospital setting, ... Critical Pathways in Cardiovascular Medicine, Second Edition presents evidence-based, ... Critical Pathways in Cardiovascular Medicine, Second Edition presents evidence-based, cost-effective critical pathways for ... Critical Pathways in Cardiovascular Medicine. Description. Critical Pathways in Cardiovascular Medicine, Second Edition ...
September 2012 - Volume 11 - Issue 3 : Critical Pathways in Cardiology
Carnegie Mellon BrainHub Scientists Visualize Critical Part of Basal Ganglia Pathways [image] | EurekAlert! Science News
Schematic of the major fiber pathways through the basal ganglia (A); visualization of the fibers shows their dorsolateral ... Carnegie Mellon University BrainHub scientists have used a non-invasive brain-imaging tool to detect the pathways that connect ... Carnegie Mellon BrainHub Scientists Visualize Critical Part of Basal Ganglia Pathways (IMAGE) view more ... Carnegie Mellon BrainHub Scientists Visualize Critical Part of Basal Ganglia Pathways (image). Carnegie Mellon University ...
Genetic pathway critical to disease, aging found - Innovations Report
Although the discovery of a new genetic pathway in cells is important, much work remains to identify how the pathway influences ... "Oxidative stress control pathways for us humans are pretty important because we live in an environment where oxygen is required ... A key enzyme in the new pathway, dubbed Star-PAP by its Wisconsin discoverers, functions as part of a complex that controls the ... "Most of the genes this pathway controls are important for human disease," according to Richard A. Anderson of the UW School of ...
Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
The Wnt signaling pathway plays a critical role in cell development, proliferation and differentiation. Mutations in this ... Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis. 26.11.2009 ... New Pathway Regulates Beta-Catenin Transactivation. The M. D. Anderson-led team made a surprising discovery: Beta-catenin also ... The newly described pathway disrupts the beta-catenin/alpha catenin complex through an EGFR-extracellular receptor kinase (ERK ...
Abdominal pain duration critical pathways - wikidoc
TOMORROW: Critical Pathways to Improved Care for Serious Illness | Bioethics Research Library
NIH study in mice uncovers pathway critical for UV-induced melanoma | National Institutes of Health (NIH)
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways | Science Translational Medicine
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ...
Critical Pathways to Success in CNS Drug Development, 1st Edition | Clinical Pharmacology & Therapeutics | Pharmacology &...
A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia | Journal of Neuroscience
A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia. Mei Li, Meiling Sun, Lijuan Cao, Jin-hua Gu, ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ...
Use of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study | CMAJ
Critical pathways as a strategy for improving care: problems and potential. Ann Intern Med 1995;123:941-8. ... Use of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study. Donald Farquhar ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ...
Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed...
Here, we demonstrate that pyroptosis, a unique inflammatory cell death pathway, occurs in the placenta predominantly from early ... Cheng, SB., Nakashima, A., Huber, W.J. et al. Pyroptosis is a critical inflammatory pathway in the placenta from early onset ... Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed ... Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed ...
Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical element of the early response to '...
... signaling pathway were highly upregulated in rough lemon. MAPK induces the transcription of WRKY and other transcription ... Yu, Q., Chen, C., Du, D. et al. Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical ... Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical element of the early response to ... Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical element of the early response to ...
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
... Nat Neurosci. 2005 Feb;8(2):212-9. doi: ... Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. ... incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway ...
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis:...
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: ... signaling pathway. The observation that these pathways are targeted by several approved drugs used to treat the symptoms of RA ... In addition, many genes in RA loci are involved in the nuclear factor-kappaB signaling pathway or the Janus kinase (JAK)-signal ... cell-type specific gene expression or epigenetic marks have highlighted regulatory T cells and CD4 memory T cells as critical ...
Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination | JCB
Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination. J. Kim Holloway, Meisha A. ... Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination ... The only data we have about the major CO pathway are defined in budding yeast by the ZMM genes (ZIP1-4, MSH4, MSH5, and MER3; ... 2, B and C), suggesting that these initial steps in the CO pathway occur normally despite the absence of BLM. However, because ...
Newly identified proteins critical to FA pathway DNA repair function
Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with ... Newly identified proteins critical to FA pathway DNA repair function. by Cincinnati Childrens Hospital Medical Center ... Citation: Newly identified proteins critical to FA pathway DNA repair function (2010, March 25) retrieved 16 June 2021 from ... phys.org/news/2010-03-newly-proteins-critical-fa-pathway.html ... Newly identified proteins critical to FA pathway DNA repair ...
Neonatal Critical Care Pathway (Professional Practice) - 2020/21 Entry - Health CPD courses | Birmingham City University
Pathway awards in Neonatal Critical Care can lead to:. *Module only Professional Practice Level 6 ... For all course enquiries please contact the Neonatal Critical Care Pathway Leader, Sue Ward-Smith on:. *Tel: +44 (0)121 331 ... Year 2 Pathway Award (BSc (Hons) Only) - Exit Award: BSc (Hons) Professional Practice (Neonatal Critical Care) ... Once you have you have completed your Foundation Course in neonates, the Critical Care pathway will develop your career in ...
A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle...
A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ...
Critical Pathways as a Strategy for Improving Care: Problems and Potential | Annals of Internal Medicine | American College of...
... the gaps in our knowledge about critical pathways are extensive; therefore, like any new health care technology, pathway ... Critical Pathways as a Strategy for Improving Care: Problems and Potential Steven D. Pearson, MD, MSc; Dorothy Goulart-Fisher, ... Critical Pathways as a Strategy for Improving Care: Problems and Potential. Ann Intern Med. 1995;123:941-948. doi: 10.7326/0003 ... A Critical Pathway for Management of Patients with Acute Chest Pain Who Are at Low Risk for Myocardial Ischemia: ...
Evaluation of a critical pathway for stroke | The Journal of the American Osteopathic Association
Evaluation of a critical pathway for stroke The Journal of the American Osteopathic Association, May 1997, Vol. 97, 269. doi: ... Evaluation of a critical pathway for stroke You will receive an email whenever this article is corrected, updated, or cited in ... Evaluation of a critical pathway for stroke . J Am Osteopath Assoc 1997;97(5):269. doi: 10.7556/jaoa.1997.97.5.269. ... After the initiation of a critical pathway that begins its interventions in the Emergency Department, the length of stay ...
Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term...
... is an inhibitor of the mTOR pathway, and work in various preparations has pointed to this pathway as being critical for ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ...
CardiologyGenesMechanistic target of rapamycinMitogen activaInhibitionPhysiology and oncogenesisIdentifies critical pathwaysMolecularLiverpool Care PathwayMTOR pathwayExtracellular signalTotal knee arthroplastyIntracellularPlays a critical roleFindingsRapamycinCancer immunotherapyCommunity-acquiredIntegrativeGuidelinesRoleClinical pathwayProliferationCorticothalamicMGluR1CellsCareResearchersHospitalsAmygdalaTumorMutationsIncreasesOutcomesGene expressionCancersGeneticallyCellGeneticPatientsCellularInterventionsPI3KDisruptsPivotalMechanismImmuneReplicationProteinsSchizophreniaMAPKCardiovascularPracticeBiologicalHumansSTINGEnzymeStudy
Cardiology1
- Thought you might appreciate this item(s) I saw at Critical Pathways in Cardiology. (lww.com)
Genes12
- Most of the genes this pathway controls are important for human disease," according to Richard A. Anderson of the UW School of Medicine and Public Health and senior author of the new Nature report. (innovations-report.com)
- A wealth of the genes involved in oxidative stress also seems to be the direct targets for the Star-PAP pathway. (innovations-report.com)
- We've discovered a novel pathway that controls expression of genes important to oxidative stress," he says. (innovations-report.com)
- Functional analysis of the differentially expressed genes (DEGs) indicated that genes involved in the mitogen activated protein kinase (MAPK) signaling pathway were highly upregulated in rough lemon. (nature.com)
- In addition, many genes in RA loci are involved in the nuclear factor-kappaB signaling pathway or the Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling pathway. (nih.gov)
- We constructed 4 gene pathway figures to explain the pathogenicity process that involves 24 key genes. (swpu.edu.cn)
- This study implicates that contrast on the gene expression of the classifications in different infection stages provides critical information for the detection of tuberculosis, and our method can be utilized to narrow down the shortlist of disease relevant genes and explore tuberculosis pathogenesis. (swpu.edu.cn)
- We applied Gene Ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis to explore biological pathways corresponding to the differentially expressed microRNAs (DEMs) associated with PA colonization. (globalresearchsyndicate.com)
- Altered transcription factor pathways and biological pathways unique to stage I serous carcinoma were identified through class comparison of differentially expressed genes.Unsupervised cluster analysis of gene expression correctly classified stage I serous carcinomas from serous borderline tumors. (unm.edu)
- Pathway analysis demonstrated the significance of p53 and E2F pathways in serous carcinogenesis and significant involvements of cell cycle and immune response pathways in stage I serous epithelial ovarian cancer.We have identified differentially expressed genes associated with the carcinogenesis of high-grade stage I serous EOC. (unm.edu)
- Furthermore, integrative analysis of biological and transcription pathway data contributed to the confirmation of important biological pathways and discovery of additional unique genes and pathways that may have potential importance in ovarian pathogenesis and biomarker development. (unm.edu)
- The cGAS-STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence or to the activation of defense mechanisms. (wikipedia.org)
Mechanistic target of rapamycin2
- and Peter K. Vogt, PhD , of Scripps Research, La Jolla, California, for their contributions to understanding the role of the phosphoinositide 3-kinase (PI3K) and mechanistic target of rapamycin (mTOR) pathways in physiology and oncogenesis. (ascopost.com)
- Cells use the mTORC1 (for "mechanistic target of rapamycin complex 1") pathway to regulate growth in response to the availability of certain nutrients, including amino acids. (mit.edu)
Mitogen activa1
- demonstrated that the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway is involved in regulating the phosphorylation state of numerous factors implicated in controlling translation initiation, including eIF4E, 4E-BP1, and the ribosomal protein S6. (jneurosci.org)
Inhibition2
- This inhibition is lost, however, when the EGFR pathway is activated. (innovations-report.com)
- Although it is clear that proteasomal inhibition results in acceleration of the aggresome pathway, the molecular effectors involved in targeting proteins to aggresome sequestration are not well studied. (asm.org)
Physiology and oncogenesis1
- for their seminal contributions to the role of the phosphoinositide 3-kinase (PI3K) and mechanistic target for rapamycin (mTOR) pathways in physiology and oncogenesis. (columbia.edu)
Identifies critical pathways1
- Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer. (unm.edu)
Molecular10
- Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. (innovations-report.com)
- A study in the March 26 Molecular Cell adds another layer of complexity to the multifaceted Fanconi anemia (FA) pathway. (phys.org)
- The precise molecular functions of the FA pathway and how they influence the development of cancers are still being uncovered. (phys.org)
- The Salk scientists identified the p53 pathway, a molecular mechanism that normally protects a cell's genetic material and suppresses tumors, as the key player in the response to telomere deprotection. (salk.edu)
- Objective: In this study, the molecular mechanism by which EPO regulates the angiogenesis after cerebral ischemia through AMPK-KLF2 signaling pathway was investigated. (begellhouse.com)
- Recent studies have provided evidence that the process of specific pathway formation may rely on a number of molecular guidance mechanisms and cues such as selective adhesion, growth cone avoidance, surface gradients, guidepost cells, and chemotropism. (begellhouse.com)
- This review is an overview of the molecular structure, as it relates to function and mechanisms of action of some of the major gene families thought to be mediating specific axonal guidance and pathway formation. (begellhouse.com)
- Researchers have uncovered a previously unknown molecular pathway that is critical to understanding cardiac arrhythmia and other heart muscle problems. (sciencedebate.com)
- Small molecules are compounds with a low molecular weight that usually inhibit the specific targets in signal transduction pathways. (biomedcentral.com)
- Molecular changes associated with age include telomere dysfunction, oxidative stress and deranged mitochondrial metabolism, inflammation, and cellular senescence, as well as altered signaling of sirtuins, insulin/insulin-like growth factor-1 (IGF-1), and the mammalian target of rapamycin (mTOR) pathway [ 3 , 4 , 5 ]. (mdpi.com)
Liverpool Care Pathway2
- AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to adult cancer patients during their last week of life in hospital. (isharonline.org)
- SETTINGS/PARTICIPANTS: The trial was performed within four hospital wards participating in the pilot implementation of the Italian version of the Liverpool Care Pathway programme. (isharonline.org)
MTOR pathway3
- In the current study, we gave infusions of RAP into the amygdala immediately after fear conditioning to determine whether disruption of the mTOR pathway in the amygdala affects fear memory formation. (jneurosci.org)
- These experiments provide evidence that translational events controlled by the mTOR pathway contribute to long-term fear memory formation in the amygdala. (jneurosci.org)
- The mTOR pathway may serve as a novel target to modulate the emergence of MDSCs in those pathophysiologic states in which these cells play an immunosuppressive role. (iupui.edu)
Extracellular signal1
- Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. (nih.gov)
Total knee arthroplasty1
- To investigate functional outcomes after the application of a critical pathway for inpatient rehabilitation of total knee arthroplasty (TKA). (bvsalud.org)
Intracellular2
- They found a new, previously unknown intracellular trafficking pathway that controls the number and location of the ion channels on the cell surface, affecting the passage of electrical charges and controlling the beat of the heart and other muscle activity. (sciencedebate.com)
- The study in Cell describes a new intracellular trafficking pathway that controls the number and location of these ion channels on the cell surface. (sciencedebate.com)
Plays a critical role3
- The Wnt signaling pathway plays a critical role in cell development, proliferation and differentiation. (innovations-report.com)
- Cellular immunity plays a critical role in mediating the protection against tuberculosis. (frontiersin.org)
- This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses. (wikipedia.org)
Findings8
- The findings show that when activated, the STING pathway triggers a natural immune response against the tumor. (genengnews.com)
- These findings could "enlarge the fraction of patients who respond to immunotherapy with prolonged control of the tumor," according to a commentary on the papers by the University of Verona's Vincenzo Bronte, M.D. "Enhancing the immunogenicity of their cancers might expand the lymphocyte repertoire that is then unleashed by interference with checkpoint blockade pathways," such as anti-PD-1. (genengnews.com)
- All pathways in this second edition have been updated to reflect the latest findings regarding best practices in all areas of cardiovascular care. (ovid.com)
- Taken together, these findings demonstrate the importance of this pathway in tumor formation and progression," Dr. Lu said, "and they reveal potential markers for prognosis and therapeutics. (innovations-report.com)
- Our findings raise the possibility that targeting the interferon-gamma pathway may represent a novel, less toxic therapeutic alternative for effective treatment of malignant melanoma patients, who currently have poor cure rates. (nih.gov)
- Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and chall. (nih.gov)
- This study provides the latest findings on critical signaling pathways governing HCC behavior and using small molecules in the control of HCC both in vitro and in vivo models. (biomedcentral.com)
- In this review, we discuss recent findings concerning the effects of aging on stem cells, contributions of stem cells to age-related pathologies, examples of signaling pathways at work in these processes, and lessons about cellular aging gleaned from the development and refinement of cellular reprogramming technologies. (mdpi.com)
Rapamycin3
- As a doctoral candidate, Dr. Sabatini studied rapamycin and went on to discover the mTOR protein and signaling pathway. (ascopost.com)
- Study of lal−/− bone marrow Ly6G+ MDSCs via transcriptional profiling showed increases in mammalian target of rapamycin (mTOR) signaling pathway transcripts. (iupui.edu)
- He went on to discover the mTOR (mechanistic target for rapamycin) protein and signaling pathway. (columbia.edu)
Cancer immunotherapy1
- Our results demonstrate that a major mechanism for innate immune sensing of cancer occurs via the host STING pathway, with major implications for cancer immunotherapy. (genengnews.com)
Community-acquired1
- Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of community-acquired pneumonia. (cmaj.ca)
Integrative3
- Critical pathway development: an integrative literature review. (semanticscholar.org)
- This paper describes the use of a care pathway designed to guide treatment by an integrative group of providers within a randomized controlled trial. (isharonline.org)
- Here we utilized a meta-dimensional integrative approach to seek genetically susceptible pathways that may be associated with tumorigenesis and progression of EC. (cdc.gov)
Guidelines5
- These pathways combine evidence-based practice parameters with guidelines for the timely completion of specific steps in the process of care. (cmaj.ca)
- 3 Key components of the pathway included a risk-stratification tool (pneumonia severity index) to guide decision-making about hospital admission, a recommendation to use a single, broad- spectrum antimicrobial agent (levofloxacin, 500 mg once daily) and guidelines for the timing of conversion from intravenous to oral antibiotic therapy and hospital discharge. (cmaj.ca)
- In an era of increasing competition in medical care, critical pathway guidelines have emerged as one of the most popular new initiatives intended to reduce costs while maintaining or even improving the quality of care.Developed primarily for high-volume hospital diagnoses, critical pathways display goals for patients and provide the corresponding ideal sequence and timing of staff actions for achieving those goals with optimal efficiency. (annals.org)
- It will be necessary to establish empirical support for critical pathway models and for the application of community practice guidelines. (freethesaurus.com)
- A single clinical pathway may refer to multiple clinical guidelines on several topics in a well specified context. (wikipedia.org)
Role15
- Understanding the role of the STING pathway provides insights into how we can 'wake up' the immune response against tumors. (genengnews.com)
- In this study, we show that CHIP has a previously unexpected critical role in the aggresome pathway. (asm.org)
- However, the role of PD pathway in regulating Th17 response to M. tuberculosis has not been investigated. (frontiersin.org)
- The PI3K pathway seems to play a pivotal role in B-CLL cell survival and growth. (nih.gov)
- This pathway-which is regulated by nutrients and insulin-sensitive PI3K signaling-is the major regulator of growth and plays a central role in physiology, metabolism, aging, and the development of cancer. (ascopost.com)
- Chapter 4 adds to the experimental evidence on the well studied residue Lys-362, for its critical role in transferring protons through the K-pathway. (illinois.edu)
- Morante, J.R. "Crystallization pathways of multicomponent oxide nanocrystals: Critical role of the metal cations distribution in the case study of metal ferrites" Crystal Growth and Design 10, 12, pp. 5176 - 5181. (irec.cat)
- These studies demonstrate that the systemic inflammatory response that affects MRL/fas lpr mice results in leukocyte rolling and adhesion in the cerebral microcirculation, and that the α 4 integrin/VCAM-1 pathway plays a central role in mediating these interactions. (monash.edu)
- Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway. (semanticscholar.org)
- The role of the IL-17 pathway in fungal sepsis remains controversial. (biomedcentral.com)
- To address these discrepancies, we assessed the differential role of IL-17 pathway in two models of fungal sepsis: intravenous infection with live Candida albicans , in which fungal growth is the main cause of mortality, and zymosan-induced multiple organ failure in which the inflammatory pathology drives the mortality. (biomedcentral.com)
- New developments in care planning will be reflected including critical pathways, and the role of models in Quality Assurance and Audit. (medicalbooks.co.nz)
- Taken together, these data support a critical role for the ECE-1/ET-1 system in inflammation- associated premature delivery. (elsevier.com)
- In this study, we investigated the role of the thalamic metabotropic glutamate receptor 1 (mGluR1)-phospholipase C β4 (PLCβ4) pathway in sleep control in PLCβ4-deficient (PLCβ4 -/- ) mice. (elsevier.com)
- Berzosertib is a selective inhibitor of DNA damage response pathway Serine/threonine-protein kinase ATR , highlighting the role of this pathway in viral replication. (ox.ac.uk)
Clinical pathway5
- Extreme prematurity clinical pathway. (aappublications.org)
- A clinical pathway, also known as care pathway, integrated care pathway, critical pathway, or care map, is one of the main tools used to manage the quality in healthcare concerning the standardisation of care processes. (wikipedia.org)
- A clinical pathway is a multidisciplinary management tool based on evidence-based practice for a specific group of patients with a predictable clinical course, in which the different tasks (interventions) by the professionals involved in the patient care are defined, optimized and sequenced either by hour (ED), day (acute care) or visit (homecare). (wikipedia.org)
- The clinical pathway concept appeared for the first time at the New England Medical Center (Boston, United States) in 1985, inspired by Karen Zander and Kathleen Bower. (wikipedia.org)
- What is a clinical pathway? (wikipedia.org)
Proliferation3
- LA JOLLA,CA-A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. (salk.edu)
- Pathways controlling cell division/proliferation like the Hippo pathway are likely candidates for regulating parasite replication. (ipl.pt)
- Targeting specific signaling pathways that are involved in HCC phenotypes such as non-stopped cell proliferation, migration, and metastasis may control the progress of the disease [ 14 , 15 ]. (biomedcentral.com)
Corticothalamic1
- The thalamic mGluR1-PLCβ4 pathway contains synapses that receive corticothalamic inputs. (elsevier.com)
MGluR11
- The results of our study showed that thalamic mGluR1-PLCβ4 pathway was critical in controlling sleep architecture. (elsevier.com)
Cells18
- Activating the pathway triggers the production of interferon-beta, which in turn alerts the immune system to the threat, helps the system detect cancerous or infected cells, and ultimately sends activated T cells into the battle. (genengnews.com)
- In the tumor microenvironment in vivo, tumor cell DNA was detected within host antigen-presenting cells, which correlated with STING pathway activation and IFN-β production," wrote the investigators. (genengnews.com)
- However, the Wisconsin group found that the newfound pathway contains a genetic "on-off" switch for a key protein known as heme oxygenase-1, an agent that protects cells from oxidative stress. (innovations-report.com)
- The discovery of a gene expression pathway and specific enzymes that exert broad influence on the process of oxidative stress has clear clinical relevance, Anderson says, because it could potentially be manipulated to mitigate the damage oxygen does to cells. (innovations-report.com)
- Oxidative stress control pathways for us humans are pretty important because we live in an environment where oxygen is required to keep us alive, but also stresses us because of oxidative damage to our cells," Anderson says. (innovations-report.com)
- Although the discovery of a new genetic pathway in cells is important, much work remains to identify how the pathway influences human disease, Anderson says. (innovations-report.com)
- Integration of GWAS results with cell-type specific gene expression or epigenetic marks have highlighted regulatory T cells and CD4 memory T cells as critical cell types in RA. (nih.gov)
- Cells have a third pathway that involves sequestration of aggregated misfolded proteins, such as the mutant form of the cystic fibrosis transmembrane conductance regulator (CFTRΔF508), into specialized "holding stations" called aggresomes ( 14 ). (asm.org)
- Reactivating the NRF2 pathway, by expressing constitutively active NRF2 (caNRF2) or treating cells with small-molecule NRF2 activators, including FDA-approved Oltipraz, rescued most HGPS cellular defects, as did treating HGPS cells with the general antioxidant N-acetyl cysteine. (cancer.gov)
- The pathway controlling G1-phase growth arrest, however, is commonly altered in cancer cells, allowing cancer cells to divide despite shortened telomeres, which can lead to the genomic instability seen in malignant cells. (salk.edu)
- When cells lose the function of p53, the gene at the center of the pathway, they can no longer arrest cells in the G1 phase, an important point in the cell cycle for repairing DNA damage or, if the damage cannot be repaired, targeting the cell for programmed death. (salk.edu)
- Because telomere deprotection results in a partial DNA damage response that only arrests cells in G1 through the p53 pathway, once cells lose p53 function telomere deprotection no longer arrests growth. (salk.edu)
- Indeed, IFN-γ-producing CD4 + T helper type 1 cells are critical for the control of M. tuberculosis in humans and murine models ( 1 - 4 ). (frontiersin.org)
- Constitutive activity of the PI3K pathway in B-CLL cells when cultured with fibroblasts prevented the downregulation of the prosurvival Bcl-2 family protein Bcl-xL and the caspase inhibitor proteins FLIPL and XIAP, and consequently caspase-3 activation and apoptosis. (nih.gov)
- FLCN 's dual roles-as a cause of a rare cancer in its mutated form and as a trigger for a growth pathway that is often hijacked in cancer cells-has prompted Tsun and Sabatini to rethink how a mutation can push cells to become cancerous. (mit.edu)
- Several signaling pathways are dis-regulated in HCC and cause uncontrolled cell propagation, metastasis, and recurrence of liver carcinoma cells. (biomedcentral.com)
- Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. (mdpi.com)
- We highlight emerging therapeutic approaches to manipulation of key signaling pathways corrupting or exhausting adult stem cells, as well as other approaches targeted at maintaining robust stem cell pools to extend not only lifespan but healthspan. (mdpi.com)
Care23
- 1993). Critical paths are a framework for coordinating team work, a route to streamlining health care delivery. (asha.org)
- Coverage includes new pathways for pre-hospital care, public access defibrillation for cardiac arrest, emergency department management of heart failure and atrial fibrillation, aortic aneurysm, hyperglycemia, peripheral artery disease and claudication, implantable cardioverter defibrillator treatment for ventricular tachycardia, and long-term management of diabetes and the metabolic syndrome. (ovid.com)
- Critical pathways as a strategy for improving care: problems and potential. (cmaj.ca)
- Once you have you have completed your Foundation Course in neonates, the Critical Care pathway will develop your career in neonatal nursing with confidence and skill. (bcu.ac.uk)
- Despite the rapid dissemination of critical pathway programs in hospitals throughout the United States, many uncertainties remain about their development, implementation, and evaluation.In addition, serious concerns have been raised about their effect on patient outcomes and satisfaction with care, physician autonomy, malpractice risks, and the teaching and research missions of many hospitals. (annals.org)
- Physicians should understand the potential benefits and problems associated with critical pathways because physicians are increasingly being asked to provide leadership for pathway programs.Physicians and other health service investigators should also develop methods to study pathways in evolving health care settings. (annals.org)
- therefore, like any new health care technology, pathway programs should be fully evaluated in order to understand the conditions under which that promise may be fulfilled. (annals.org)
- The essential tool of managed care systems is a critical pathway, which is developed through the collaboration of health care team members. (semanticscholar.org)
- Critical care is now used as a term that encompasses intensive care or intensive therapy provided in intensive care units (ICUs) or intensive therapy units (ITUs), together with what used to be called high-dependency care provided in high-dependency units (HDUs). (nice.org.uk)
- Recently the distinctions have become blurred, hence the increasing use of the term critical care. (nice.org.uk)
- Approximately 110,000 people spend time in critical care units in England and Wales each year, the majority surviving to be discharged home. (nice.org.uk)
- For many, discharge from critical care is the start of an uncertain journey to recovery characterised by, among other problems, weakness, loss of energy and physical difficulties, anxiety, depression, post-traumatic stress (PTS) phenomena and, for some, a loss of mental faculty (termed cognitive function). (nice.org.uk)
- Care pathways have been developed with the aim of ensuring that dying patients and their family members received by health professionals the most appropriate care. (isharonline.org)
- This review presents and discusses the evidence supporting the effectiveness of the end-of-life care pathways. (isharonline.org)
- Models and Critical Pathways in Adult Hospital-Based Care. (medicalbooks.co.nz)
- The book will remain practical and critical in style, encouraging a creative response to the use of models in nursing care. (medicalbooks.co.nz)
- It is dedicated to the fond memories of Nasir Iqbal Chaudhry with a message to develop efficient and humane critical care units throughout Pakistan. (pulsepakistan.com)
- I have been unable to find more recent figures.Our goal is to train future leaders in academic pulmonary and critical care medicine. (kaleiseminari.com)
- Since then, critical pathways -- also called Critical Pathway Care Maps, Action Plans, Multidisciplinary Action Plans, or Clinical Pathways -- have been adapted to meet the needs of different health care organizations that are implementing so-called case management models, the basis of subacute care programs that are evolving today. (freethesaurus.com)
- Clinical pathways aim to promote organised and efficient patient care based on evidence-based medicine, and aim to optimise outcomes in settings such as acute care and home care. (wikipedia.org)
- Managed care organizations often view clinical pathways in a similar way as they view care plans, in which the care provided to a patient is definitive and deliberate. (wikipedia.org)
- Clinical pathways (integrated care pathways) can be seen as an application of process management thinking to the improvement of patient healthcare. (wikipedia.org)
- and ultimately as a single unified legal record of the care the patient has received, and the progress of their condition, as the pathway has been undertaken. (wikipedia.org)
Researchers3
- The researchers also report that loss of MHF1 alone disrupts normal function of the entire FA pathway. (phys.org)
- Whitehead Member David Sabatini and other researchers have teased apart many components of this pathway, but the precise mechanism by which nutrient levels are actually sensed has remained elusive. (mit.edu)
- Researchers say the pathway could be modulated with the help of transcranial magnetic stimulation or transcranial direct current stimulation. (sanedoublethink.com)
Hospitals3
- Many hospitals in Canada and the United States have implemented critical pathways (CPs) to reduce variation and control costs in the management of several common conditions. (cmaj.ca)
- Steps were taken to ensure that treating personnel at the hospitals allocated to conventional management had no knowledge of any of the constituent parts of the critical pathway. (cmaj.ca)
- Reflects new developments including patient-focussed hospitals and critical pathways. (medicalbooks.co.nz)
Amygdala2
- Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues. (nih.gov)
- The amygdala is thought to be the brain area where critical synaptic plasticity occurs, supporting the formation of fear memory ( Fanselow and LeDoux, 1999 ). (jneurosci.org)
Tumor1
- The research also found that targeted high-dose radiation therapy dials up the activation of this pathway, which promotes immune-mediated tumor control. (genengnews.com)
Mutations3
- Mutations in this important pathway leading to the activation of beta-catenin are responsible for many types of cancer, including colon cancer. (innovations-report.com)
- The M. D. Anderson-led team made a surprising discovery: Beta-catenin also can travel to the nucleus via activation of the EGFR pathway-and it does so independently of Wnt signaling or mutations. (innovations-report.com)
- Chapter 2 describes the characteristics of mutations at the residue Met-107 near the critical proton transferring residue in the D-pathway, Glu-286. (illinois.edu)
Increases1
- TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. (jneurosci.org)
Outcomes2
- Capitated health plans are embracing critical pathways as a superior way to manage costs and ensure high-quality outcomes for inpatients and outpatients alike. (freethesaurus.com)
- Clinical pathways aim for greater standardization of treatment regimens and sequencing as well as improved outcomes, from both a quality of life and a clinical outcomes perspective. (wikipedia.org)
Gene expression1
- Now, writing in the current edition (Feb. 21, 2008) of the journal Nature, a team of University of Wisconsin-Madison scientists reports the discovery of a gene expression pathway that exerts a sweeping influence over the process of oxidative stress. (innovations-report.com)
Cancers1
- This is an unexpected finding, as some cancers keep this pathway turned on to fuel their unchecked growth and expansion. (mit.edu)
Genetically1
- In some people the pathway is genetically unstable, putting them at risk for the Fanconi anemia blood disorder , physical defects and possibly cancer. (phys.org)
Cell12
- A key enzyme in the new pathway, dubbed Star-PAP by its Wisconsin discoverers, functions as part of a complex that controls the expression of messenger RNA, all-important molecules that carry genetic information from the nucleus of a cell to the cytoplasm where proteins are made. (innovations-report.com)
- A key component of the Wnt pathway, beta-catenin combines with alpha-catenin and regulates cell-cell adhesion. (innovations-report.com)
- Here, we demonstrate that pyroptosis, a unique inflammatory cell death pathway, occurs in the placenta predominantly from early onset PE, as evidenced by elevated levels of active caspase-1 and its substrate or cleaved products, gasdermin D (GSDMD), IL-1β, and IL-18. (nature.com)
- Mounting scientific evidence suggests the FA repair pathway is necessary to limit genomic instability caused by abnormal structural changes during DNA replication and cell division. (phys.org)
- Rapid clearance of the master regulator, CtrA, by the ClpXP protease is a critical event that enables the initiation of chromosome replication at specific times in the cell cycle. (pnas.org)
- The regulation of cell cycle pathways requires the precise timing of both production and degradation of regulatory proteins. (pnas.org)
- Here, we report the identification of a protein, CpdR, that directs ClpXP localization to the cell pole and show that CpdR function is under the control of a phospho-signaling pathway, thus establishing a mechanism for providing temporal and spatial specificity to bacterial proteases. (pnas.org)
- So when you lose this nutrient switch or if it can't be turned on, then the cell seems to freak out and cause all other growth promoting pathways to be turned on to somehow overcompensate for this loss. (mit.edu)
- The major symptoms of these diseases include rising breathlessness, frequent chest infections, and constant cough with phlegm "Introduction," Jining Lu microRNAs as critical posttranscriptional regulators in airway epithelial or lung mesenchymal cell differentiation in response to injury Dr. (kaleiseminari.com)
- Some well-studied pathways, such as p53 signaling and cell cycle pathways, show consistently high rankings across different analyses. (cdc.gov)
- Additionally, other cell signaling pathways (e.g. (cdc.gov)
- This unit will outline how critical molecules, pathways and mechanisms regulate cell growth and development, and examine the pathological consequences of aberrant control. (bris.ac.uk)
Genetic2
- Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with Fanconi anemia and how otherwise healthy people are susceptible to cancer from environmentally triggered DNA damage. (phys.org)
- IGF-1/mTOR, rac-1 and IL-5 pathway), genetic information processing pathway (e.g. homologous recombination) and metabolism pathway (e.g. sphingolipid metabolism) are also highly associated with EC risks, diagnosis and prognosis. (cdc.gov)
Patients5
- However, the tissue origin and the pathways that contribute to circulating alarmins and inflammatory cytokines in PE patients remain poorly understood. (nature.com)
- Research on the longer-term consequences of critical illness has shown that significant numbers of patients surviving critical illness have important continuing problems. (nice.org.uk)
- Patients who underwent critical pathway rehabilitation after TKA showed significant improvements in functional measurements during the first 3 months post-surgery. (bvsalud.org)
- The pathway design tries to capture the foreseeable actions which will most commonly represent best practice for most patients most of the time, and include prompts for them at the appropriate time in the pathway document to ascertain whether they have been carried out, and whether results have been as expected. (wikipedia.org)
- The combined variances for a sufficiently large population of patients are then analysed to identify important or systematic features, which can be used to improve the next iteration of the pathway. (wikipedia.org)
Cellular3
- Understanding the cellular processes responsible for the triage of misfolded proteins is critical for elucidating the pathophysiology of many diseases associated with misfolded proteins. (asm.org)
- Whitehead Institute scientists report that FLCN , the gene mutated in the rare hereditary disorder known as Birt-Hogg-Dubé cancer syndrome, is important for the activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway. (mit.edu)
- New understanding of the cellular signalling pathways involved in SARS-CoV-2 infection. (ox.ac.uk)
Interventions1
- After the initiation of a critical pathway that begins its interventions in the Emergency Department, the length of stay decreased to 6.33 days. (jaoa.org)
PI3K2
- The three scientists honored with the 2019 Louis Gross Horwitz Prize played key roles in identifying and deciphering the PI3K pathway. (ascopost.com)
- Dr. Cantley's laboratory discovered the PI3K signaling pathway in the mid-1980s. (ascopost.com)
Disrupts1
- The newly described pathway disrupts the beta-catenin/alpha catenin complex through an EGFR-extracellular receptor kinase (ERK)-protein kinase CK2- phosphorylation cascade. (innovations-report.com)
Pivotal1
- Notably, TGF/SMAD, JAK/STAT, Notch and Wnt/β-catenin signaling pathways may play pivotal roles in this HBV-driven HCC via several circRNAs. (frontiersin.org)
Mechanism2
- Both CtrA and CpdR are phosphorylated via the same CckA histidine kinase phospho-signaling pathway, providing a reinforcing mechanism that simultaneously activates CtrA and prevents its degradation by delocalizing the CpdR/ClpXP complex. (pnas.org)
- Impaired activity of the NRF2 antioxidant pathway is a driver mechanism in Hutchinson-Gilford progeria syndrome (HGPS). (cancer.gov)
Immune1
- The cGAS - STING pathway acts to detect cytosolic DNA and induce an immune response. (wikipedia.org)
Replication1
- Human Mob1 participates in this pathway and our recent data suggests it is an excellent candidate for the control of parasite replication/number. (ipl.pt)
Proteins3
- The proteins were identified working through a specific core component protein of the FA pathway called FANCM, one of eight currently known to make up the FA core complex. (phys.org)
- Proteins that are not amenable to the chaperone refolding pathway are targeted for degradation by the ubiquitin proteasome pathway. (asm.org)
- Recently, Sabatini and his lab determined that a family of proteins known as Rag GTPases act as a switch for the pathway-when nutrients are present, the Rag proteins turn on the mTORC1 pathway. (mit.edu)
Schizophrenia1
- Study identifies a neural pathway associated with error monitoring and attention function in some psychiatric disorders such as ADHD, ASD, and schizophrenia. (sanedoublethink.com)
MAPK1
- Additionally, ghrelin activated P38 MAPK, AKT, and ERK1/2 pathways and also induced P38 MAPK phosphorylation in high glucose conditions. (edu.lb)
Cardiovascular1
- Background Liaison critical pathways (LCPs) for coronary artery disease (CAD) were developed to aid collaborative look after CAD sufferers between cardiologists in crisis clinics and referring doctors through writing of medical details, including cardioprotective medicines and cardiovascular risk elements. (cancerdir.com)
Practice1
- Pathways, Second Edition: Listening, Speaking, and Critical Thinking is a global, five-level academic English program with carefully-guided lessons and explicit listening and speaking practice that develops the language skills, critical thinking, and learning strategies required for academic success. (eltngl.com)
Biological1
- However, the biomarkers and biological pathways underlying these associations are unclear. (globalresearchsyndicate.com)
Humans2
- Thus, as others have suggested, the trehalose pathway is worth exploiting as an antifungal drug target given its conservation in other pathogenic fungi and absence in humans. (aspergillus.org.uk)
- Experiments with congenitally deaf children fit with cochlear implants at different times during childhood have allowed us to establish the existence and time limits of a critical period for the development of central auditory pathways in humans. (isca-speech.org)
STING3
- Detection of such "cytosolic" DNA initiates a series of interactions that lead to the STING pathway. (genengnews.com)
- New agents that stimulate the STING pathway are being developed as potential cancer therapeutics. (genengnews.com)
- One way cytosolic DNA is sensed is via the cGAS/STING pathway, specifically by the cyclic-GMP-AMP synthase (cGAS). (wikipedia.org)
Enzyme1
- Zinc is a co-factor for at least 70 critical enzyme pathways. (nutramed.com)
Study5
- In this study, we have characterized the trehalose pathway in A. fumigatus for the first time. (aspergillus.org.uk)
- In this study, we demonstrate a new technique for assessing and reconstructing human-mediated pathways of alien forest species entries to major settlements in Canada via commercial road transportation and domestic trade. (gc.ca)
- In the present study, we investigated the effect of ghrelin on podocyte survival as well as the signalling pathways mediating ghrelin effect in immortalized cultured rat podocytes. (edu.lb)
- This study illuminates a new pathway for therapeutic intervention,' says Paul Welling, M.D., professor of physiology at the University of Maryland School of Medicine. (sciencedebate.com)
- We analyzed GWAS data obtained from Connecticut Endometrial Cancer Study (CECS) and identified the top 20 EC susceptible pathways. (cdc.gov)