Schedules of medical and nursing procedures, including diagnostic tests, medications, and consultations designed to effect an efficient, coordinated program of treatment. (From Mosby's Medical, Nursing & Allied Health Dictionary, 4th ed)
The study of the heart, its physiology, and its functions.
The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).
An organized procedure carried out through committees to review admissions, duration of stay, professional services furnished, and to evaluate the medical necessity of those services and promote their most efficient use.
The period of confinement of a patient to a hospital or other health facility.
The capacity of an organization, institution, or business to produce desired results with a minimum expenditure of energy, time, money, personnel, materiel, etc.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
A cell line derived from cultured tumor cells.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
A general term referring to the learning of some particular response.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.

Experience with a managed care approach to HIV infection: effectiveness of an interdisciplinary team. (1/353)

To evaluate the function and effectiveness of a multidisciplinary team for managing human immunodeficiency virus (HIV) infection, we conducted a follow-up cohort study of HIV-positive patients managed according to a clinical care path at a staff-based health maintenance organization (HMO). The study group consisted of 230 HIV-positive health plan members who received care at the Kaiser Permanente Santa Rosa medical center (KPMC-SRO). In 1994, the comparison group consisted of 4747 HIV-positive health plan members who received care at Kaiser Permanente's 18 other medical centers in northern California. The percentages of acquired immunodeficiency syndrome (AIDS) and HIV-positive patients as determined by CD4+ T-cell counts were similar (P = 0.97). Compared with patients at the other Kaiser Permanente medical centers, KPMC-SRO patients had more visits with nurse practitioners (rate ratio [RR] = 1.72) and nutritionists (RR = 12.3) and fewer visits with primary care physicians (RR = 0.82). More HIV-positive members at KPMC-SRO received social workers' services (27% at KPMC-SRO vs 6% for patients at the other Kaiser Permanente medical centers) and fewer used emergency services (RR = 0.92) and psychiatric services (RR = .89). At KPMC-SRO, the mean number of days that AIDS patients spent in the hospital decreased from 7.8 (1991) to 2.01 (1994). Hospital admissions were fewer (AIDS patients, RR = 0.67; HIV-positive patients without AIDS, RR = 0.45), and length of stay was briefer, compared with patients at the other Kaiser Permanente Medical Centers. The mean cost of HIV-related drugs for patients seen at KPMC-SRO ($2343 per infected member) was lower than that for patients seen elsewhere in the region ($3289 per infected member). These results suggest that in an HMO setting, managed care provided by a dedicated interdisciplinary team according to a clinical care path can substantially and favorably affect resource use.  (+info)

The development and implementation of normal vaginal delivery clinical pathways in a large multihospital health system. (2/353)

The entire country has become more concerned with healthcare costs due to managed care, capitation risk-based contracts, and the near elimination of the cost-plus reimbursement system. Clinical pathways have become one way to reduce unnecessary resource consumption by reducing provider variance, improving clinical outcomes, and reducing cost. We present here our rationale and process for developing a common clinical pathway for normal vaginal delivery in a large and varied multihospital system. We also discuss how this new pathway is expected to improve quality of care and reduce costs.  (+info)

Influence of a critical path management tool in the treatment of acute myocardial infarction. Clinical Quality Improvement Network Investigators. (3/353)

OBJECTIVE: The primary objective of this study was to determine the effect of implementing a critical path on use of proven efficacious therapies and outcomes in patients admitted to a hospital with acute myocardial infarction (AMI). The secondary objectives were to evaluate the use of unproven medications and to develop an understanding of the factors associated with adverse in-hospital outcomes in these patients. STUDY DESIGN: A nonrandomized before-after study design was used to evaluate the efficacy of a critical path instrument in patients admitted to hospital with AMI. PATIENTS AND METHODS: Consecutive patients admitted with AMI in nine participating hospitals were enrolled in the study. The critical path instrument consisted of a locally developed, preprinted physician order form. Practice patterns were determined before (n = 2305) and after (n = 2349) implementation of the critical path by primary chart review. Multivariate analysis of risk factors for mortality was performed on a combined database of 6088 AMI patients. RESULTS: The use of acetylsalicylic acid (ASA), nitrates, and beta blockers increased significantly by 3%, 2%, and 9%, respectively, after implementation of the critical path. Use of thrombolytics remained stable at 41%, and calcium channel blocker use decreased significantly by 8%. In-hospital mortality decreased by 1%. There was less use of ASA, nitrates, beta blockers, and thrombolytic therapy in women and the elderly. Multivariate analysis showed that advanced age was associated with increased mortality risk, whereas ASA, beta blockers, nitrates, and calcium channel blockers were associated with reduced mortality risk. CONCLUSION: Implementation of a critical path resulted in increased use of proven efficacious therapies, reduced use of noneffective therapy, and a trend toward reduced mortality.  (+info)

Evaluating and improving the delivery of heart care: the University of Michigan experience. (4/353)

With increasing pressure to curb escalating costs in medical care, there is particular emphasis on the delivery of cardiovascular services, which account for a substantial portion of the current healthcare dollar spent in the United States. A variety of tools were used to improve performance at the University of Michigan Health System, one of the oldest university-affiliated hospitals in the United States. The tools included initiatives to understand outcomes after coronary bypass operations and coronary angioplasty through use of proper risk-adjusted models. Critical pathways and guidelines were implemented to streamline care and improve quality in interventional cardiology, management of myocardial infarction, and preoperative assessment of patients undergoing vascular operations. Strategies to curb unnecessary costs included competitive bidding of vendors for expensive cardiac commodities, pharmacy cost reductions, and changes in nursing staff. Methods were instituted to improve guest services and partnerships with the community in disease prevention and health promotion.  (+info)

Infrarenal aortic surgery with a 3-day hospital stay: A report on success with a clinical pathway. (5/353)

PURPOSE: This paper reports on an experience with a clinical pathway for elective infrarenal aortic surgery (AS) that targeted hospital discharge on postoperative day (POD) 3. The pathway incorporated early feeding, early ambulation, and selective use of the intensive care unit (ICU). METHODS: A review of 50 consecutive hospital discharges after AS (aneurysm repair and aortofemoral bypass grafting) by a single surgeon performed from April 1996 through June 1998 with this clinical pathway is reported. The data collected included morbidity rate, mortality rate, length of stay (LOS), and number of hospital readmissions. RESULTS: The average LOS for all patients was 3.0 days. Only six patients (12%) were admitted to the ICU. Discharge on POD 3 was achieved in 80% of the group (40 of 50), and increasing experience improved compliance, with 92% of the most recent 25 patients (23 of 25) being discharged by POD 3. Eleven of these 25 patients (44%) were discharged on POD 2. No patient was readmitted to the hospital within a 30-day period after discharge. There was no mortality after AS during this period. CONCLUSION: Factors that limit the discharge of patients recovering from AS include the ability to ambulate independently and to tolerate a diet. Ambulation and feeding on POD 1 were well tolerated by most patients, which shortened the period of hospitalization. Admission to the ICU was infrequently required when a monitored surgical step-down unit was available. Discharge by POD 3 for AS has been proven to be routinely achievable, safe, and well accepted by patients and to reduce the cost of hospitalization.  (+info)

The role of clinical practice guidelines in disease management. (6/353)

This activity is designed for medical directors, pharmacy directors, quality assurance managers, and all members of disease management or quality improvement teams. GOAL: To review the guideline literature and help healthcare organizations plan guideline development and implementation strategies. OBJECTIVES: 1. Clarify the terminology used in practice policy development. 2. Explain how guideline implementation is related to disease management. 3. Discuss interventions utilized to enhance guideline adoption. 4. Provide a stepwise plan for healthcare organizations to follow.  (+info)

New picture archiving and communications system plus new facility equals critical path planning challenge. (7/353)

The architectural design and construction of a new imaging department is one of the most complex challenges in healthcare architecture. When a client also plans a simultaneous change in basic operating system technology from film-based to filmless imaging, the challenge for both hospital management and the facility/technology design team is even more complicated. A purposeful planning process plus a carefully composed team of internal and external experts are the two essentials for success in executing this difficult conversion of both facility and technology.  (+info)

A community hospital-based congestive heart failure program: impact on length of stay, admission and readmission rates, and cost. (8/353)

OBJECTIVE: To do an analysis of patients with a primary diagnosis of congestive heart failure at discharge before (n = 407) and after (n = 347) the implementation of a comprehensive inpatient and outpatient congestive heart failure program consistent with the guidelines of the Agency for Health Care Policy and Research. STUDY DESIGN: A retrospective analysis of the impact of the congestive heart failure program on length of stay, admission and readmission rates, and costs to both patient and provider. The program, which used a multidisciplinary team approach, included an intensive education program focusing on diet, compliance, and symptom recognition, as well as the use of outpatient infusions. It also incorporated aggressive pharmacologic treatment for patients with advanced congestive heart failure. RESULTS: Our analysis revealed significant decreases in length of stay, admission and readmission rates, and costs to the patient and provider (P < or = .05). The mean cost per admission decreased 17% ($1118), and a substantial 77% ($718,468) net reduction in nonreimbursed (lost) hospital revenue was noted. CONCLUSION: A multidisciplinary, comprehensive congestive heart failure program can improve patient care in a community-hospital setting while significantly reducing costs to both the patient and the institution.  (+info)

Synonyms for critical pathway in Free Thesaurus. Antonyms for critical pathway. 4 synonyms for pathway: nerve pathway, nerve tract, tract, footpath. What are synonyms for critical pathway?
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Suboptimal quality of care is an evident issue in current healthcare services. Clinical pathways (CPs) have the potential to facilitate evidence-based practice and interprofessional teamwork, and thereby improve patient safety and quality of care.. The overall aim of the thesis was to develop comprehensive empirical knowledge and understanding of CP implementation and teamwork in Swedish intensive care units (ICUs). Four studies were included (I-IV).. Study I was a survey including all Swedish ICUs (N84) and a document analysis of CP examples (n12). In total, 17 (20%) ICUs used CPs and many had implementation plans. The quality, extent and content of the CPs (n56) varied greatly, with sometimes insufficient interprofessionalism, evidence base and renewal.. Study II was a mixed method including ICUs using CPs. The implementation processes were retrospectively explored through questionnaire data (n15) and qualitative content analysis of interviews with key informants (n10). The CP implementation ...
ASCO today released Criteria for High-Quality Clinical Pathways in Oncology, a set of 15 inter-related criteria that provide an overarching framework for assessing pathway programs in the United States. ASCO developed the criteria to guide stakeholders in assessing the quality, utility, and integrity of clinical pathways in oncology.. Rising health-care costs and the overall shift toward a value-based health-care delivery system have led to the rapid proliferation of clinical pathways in oncology. In fact, according to DK Pierce & Associates, Inc, an estimated 60 individual health insurance plans in the United States are currently using or developing oncology-specific pathways, and in 2010, approximately 15% of oncology covered lives were treated according to clinical pathways-a number which was expected to rise to 25% in 2015, according to McKinsey & Company.. Well-designed and effectively implemented clinical pathways can support the delivery of evidence-based cancer care, while enhancing ...
BACKGROUND AND PURPOSE: The International Subarachnoid Aneurysm Trial (ISAT) reported that endovascular coiling yields better clinical outcomes than surgical clipping at 1 year. The high cost of the consumables associated with the endovascular coiling procedure (particularly the coils) led health care purchasers to conclude that coiling was a more costly procedure overall. To examine this assumption and provide evidence for future policy, accurate and comprehensive data are required on the overall resource usage and cost of each strategy. METHODS: We provide detailed results of patient treatment pathways, resource utilization, and costs up to 24 months postrandomization for endovascular and neurosurgical treatment of aSAH. We report data on costs related to initial and subsequent procedures (ward days, ITU, equipment, staff, consumables, etc), adverse events, complications, and follow up. The data are based on a subsample of all patients randomized in ISAT, containing all patients across 22 UK centers
Definition of clinical pathway in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is clinical pathway? Meaning of clinical pathway as a legal term. What does clinical pathway mean in law?
Describing the characteristics, treatment pathways, outcomes, and costs of people with persistent noncancer pain managed by community pain clinics and generating an indicative estimate of cost-effectiveness: feasibility study protocol Shiekha AlAujan,1 Saja AlMazrou,1 Roger D Knaggs,1,2 Rachel A Elliott11Division for Social Research in Medicines and Health, The School of Pharmacy, University of Nottingham, Nottingham, UK; 2Pharmacy Department and Pain Management Service, Nottingham University Hospitals NHS Trust, Nottingham, UKBackground: Low back pain (LBP) and fibromyalgia (FM), also known as chronic widespread pain (CWP), are highly prevalent chronic painful conditions that have substantial impact on patients, health care systems, and society. Diagnosis is complex and management strategies are associated with various levels of evidence for effectiveness and cost-effectiveness. Multidisciplinary pain services have been shown to be effective in some settings and therefore are recommended by clinical
An easy-to-follow summary of the Primary Care Dermatology Society treatment pathway for the assessment and management of psoriasis based on site of psoriasis.
An easy-to-follow summary of the Primary Care Dermatology Society treatment pathway for the assessment and management of psoriasis based on site of psoriasis.
Evershed, S. (2010) A Treatment Pathway for High Security Offenders with a Personality Disorder, in Working Positively with Personality Disorder in Secure Settings: A Practitioners Perspective (eds P. Willmot and N. Gordon), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470973110.ch5 ...
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Clinical pathways are becoming important to the provision of efficient and effective health care. A clinical pathway is a tool by which a clinical practice guideline based on the best available evidence is adapted for implementation in a specific setting. Pathways involve input from all members of the healthcare team and form part or all of the patients record, allowing documentation of interventions, progress, and outcome. Pathways promote standardisation of care and may be based on diagnoses, symptoms, or procedures.1 Campbell et al suggest that although a sizeable literature exists about the development of care pathways, there are few evaluations of their effectiveness in changing practice and improving patient outcomes.2 The study by Dowsey et al is one of the first randomised controlled trials to evaluate the effectiveness of a clinical pathway.. Strengths of the study include random allocation to comparison groups by a clerical assistant who was unaware of the patients clinical profile ...
Objective: To design, implement and assess a clinical pathway for lower-extremity deep venous thrombosis, and to compare the length of hospital stay in two different periods.. Design: Development of the care pathway by a multidisciplinary team, followed by a controlled intervention study to compare two non-concomitant cohorts of patients corresponding to the years 2002 (before the implementation of the critical pathway) and 2004 (year of the implementation).. Setting: Academic tertiary care hospital.. Participants: 90 patients, 42 corresponding to the year 2004 and 48 to 2002, admitted to hospital with a diagnosis of lower-extremity deep venous thrombosis (DVT).. Main outcome measures: Length of hospital stay, hospitalisation costs and care indicators.. Results: The mean length of hospital stay was 6.78 days in 2002 and 4.72 days in 2004. This means a reduction of 2.06 days (p,0.012). The reduction in the length of hospital stay in 2004 situates the hospital 1.98 days below the mean stay of our ...
BCB Medical is a provider of pioneering information systems to the health care sector. Our clinical pathway systems are designed to assist doctors and nursing staff in their everyday management of clinical pathways for the benefit of their patients.. We serve as your guide in the world of information management and bring a strong trio of support to clinical pathway implementation: efficiency improvement, treatment quality and effectiveness follow-up, and comparability of medical information.. BCB Medical. ScanBalt Business Club. ...
Background. Clinical pathways are increasingly being used by hospitals to improve efficiency in the care of certain patient populations ; however little prospective data are available to support their use. This study examined whether using a clinical pathway for patients undergoing ileal pouch/anal anasto-mosis, a complex procedure in which we...
And appropriate items in the clinical pathway are listed in the following eight categories: treatment; medications; observation, including a check of vital signs; laboratory tests, such as complete blood count and blood chemistry; activity; nutrition; education; and variance (Fig. 8). Based on the clinical pathway process, we treated patients with benign prostate hypertrophy. At hospitalization, nurse specialists in the urological ward educated the patient and his family about the pre- and post operation process. Through such multidisciplinary collaboration, the length of hospitalization and hospital costs were successfully reduced, while the quality care indicators were all maintained. This chapter describes the development of this clinical pathway and also demonstrates the outcomes after implementation. Key Words. Clinical pathway, Transurethral resection of prostate, Length of hospitalization, Hospital charge Introduction The concept of developing clinical pathways originated in the ...
Systems useful for analyzing data related to clinical pathways and performing actions based upon the analyses. A self-analyzing system for suggesting default clinical pathways for various procedures. A self-analyzing system for suggesting deviation from a current clinical pathway and entry into an alternative clinical pathway based upon historical information about the results of actions. Statistical analysis systems based on clinical pathways. A rating system for care providers or proposed pathways based on historical information. Systems for gathering clinical pathway information. Systems for tracking clinical pathway outcomes based on data collected post-treatment. A system for prequalification for appropriate discharge and post-discharge handling of and communication with a new class of patient, those requiring stable acute care. A questionnaire computer language and subsystem are used in various stages of the systems of the invention. Corresponding methods are also disclosed.
BACKGROUND: Hospital is the most common place of cancer death but concerns regarding the quality of end-of-life care remain. AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to adult cancer patients during their last week of life in hospital. DESIGN: Uncontrolled before-after intervention cluster trial. SETTINGS/PARTICIPANTS: The trial was performed within four hospital wards participating in the pilot implementation of the Italian version of the Liverpool Care Pathway programme ...
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Duodenal papilla carcinoma (DPC) is a rare malignancy of the gastrointestinal tract with high recurrence rate, and the pathogenesis of this highly malignant neoplasm is yet to be fully elucidated. This study aims to identify key genes to further understand the biology and pathogenesis underlying the molecular alterations driving DPC, which could be potential diagnostic or therapeutic targets. Tumor samples of three DPC patients were collected and integrating RNA-seq analysis of tumor tissues and matched normal tissues were performed to discover differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were carried out to understand the potential bio-functions of the DPC differentially expressed genes (DEGs). Protein-protein interaction (PPI) network was constructed for functional modules analysis and identification of hub genes. qRT-PCR of clinical samples was conducted to validate the expression level of the hub genes. A total of
TABLE-US-00001 TABLE 1 Dynamic Biomarkers and Applications Physiological/ Clinical or Medical Medical Area Biomarker Disease or Condition Molecule of interest Metabolism/ adipose triglyceride Obesity; lipoatrophy; Glycerol or fatty Nutrition/Endo- dynamics fat distribution; acids derived from crinology hyperplasia- triglyceride. hypertrophy Adipocyte dynamics hyperplasia- DNA isolated from hypertrophy; response adipocytes to compounds or therapeutics. Muscle mitochondrial Unfitness; DNA from muscle DNA or phospholipid cardiovascular disease mitochondria or dynamics risk; autotoxicity phospholipids (e.g., drugs; deconditioning; cardiolipin) from frailty muscle mitochondria. Muscle protein Frailty; wasting; Protein derived dynamics sports; dystrophies from muscle (e.g., total muscle protein or myosin) Dynamics of adipose Atherosclerosis; Glycerol or fatty lipolysis diabetes mellitus risk acids derived from triglyceride. Dynamics of adipose or carbohydrate Fatty acids hepatic overfeeding; anabolic ...
The production of professional-inflammatory mediators by GM-CSF-primed BMDMs is dependent on the adaptor protein MyD88 and the nuclear translocation of NFkBp65.
Background and Aims: Our understanding of patient pathways through specialist Alcohol and Other Drug (AOD) treatment and broader health/welfare systems in Australia remains limited. This study examined how treatment outcomes are influenced by continuity in specialist AOD treatment, engagement with non-AOD community services, and mutual aid, as well as exploring differences between clients who present with a primary alcohol problem compared to those presenting with a primary drug issue. Method: In a prospective, multi-site treatment outcome study, 796 clients from 21 AOD services in Victoria and Western Australia completed a baseline interview between January 2012 and January 2013. 555 (70%) completed follow-up assessment of subsequent service use and AOD use outcomes 12-months later. Results: Just over half of the participants (52.0%) showed reliable reductions in use of, or abstinence from, their primary drug of concern. This was highest among clients who reported meth/amphetamine (66%) as ...
Methods We developed a 10-year Markov model describing the treatment pathway of patients with PsA who had failed prior oral DMARD therapy, using monthly cycles. Clinical efficacy data were obtained from published pivotal study results and literature. Costs, resource utilisation and treatment pathways were obtained from the literature and expert opinion. Patients transitioned through two lines of biologics (etanercept, infliximab, golimumab or adalimumab as first or second line) followed by best supportive care. Response to therapy was defined as the probability of PsARC response at the end of the trial period. Patients transitioned to the next line of therapy in case of non-response or discontinuation due to other causes (a short-term annual drop-out rate of 32% and a long-term rate of 16.5% were assumed). All-cause death was included and adjusted to reflect the increased mortality associated with PsA. Treatment and administration, monitoring, and hospitalisation costs were included. An annual ...
Background: AML is one of the most common and acute diseases among the types of leukaemia. The treatment costs for AML/APML are considerably high as it involves the use of expensive treatments (such as stem cell transplantation). Over the past 20 years, the topic has attracted the interest of an increasing number of economic evaluation researchers, with the goal of reducing the related costs without compromising the quality of care and the clinical outcomes. However, no relevant overall/lifetime treatment cost study has been carried out yet, mainly due to UK data availability constraints. Taking the above into consideration, the aim of the study was to calculate the overall/lifetime treatment costs by applying the bottom-up method. Methods: In order to obtain overall/lifetime cost for AML/APML treatments, an innovative three-phase costing study was conducted on 239 newly diagnosed (during September 2004 to September 2006) adult AML/APML patients in Haematological Malignancy Research Network ...
Observational research promises to complement experimental research by providing large, diverse populations that would be infeasible for an experiment. Observational research can test its own clinical hypotheses, and observational studies also can contribute to the design of experiments and inform the generalizability of experimental research. Understanding the diversity of populations and the variance in care is one component.
Acta Neurochir (2017) 159:1457-1478. An understanding of the present standing of surgery, surgical results and the role in altering the future morbidity and mortality of untreated brain arteriovenous malformations (bAVMs) is appropriate considering the myriad alternative management pathways (including radiosurgery, embolization or some combination of treatments), varying risks and selection biases that have contributed to confusion regarding management. The purpose of this review is to clarify the link between the incidence of adverse outcomes that are reported from a management pathway of either surgery or no intervention with the projected risks of surgery or no intervention.. Methods A critical review of the literature was performed on the outcomes of surgery and non-intervention for bAVM. An analysis of the biases and how these may have influenced the outcomes was included to attempt to identify reasonable estimates of risks.. Results In the absence of treatment, the cumulative risk of ...
A network cabinet is provided comprising a base member, two pairs of vertical frame rail members connected to the base member, and a top cover supported by at least one of the vertical frame rail members. The base member defines an opening and another opening is defined in the top cover. The vertical frame rail members are positioned spaced apart from four sidewalls from four corners of the cabinet formed by the four sidewalls, where each sidewall comprises a panel or a door. The two pairs of vertical frame rail members and the four sidewalls define at least one cable management pathway and at least a portion of the cable management pathway is vertically aligned with at least a portion of the opening of the base member and the opening of the top cover.
Rationale, aims and objectives Clinical pathways (CPs) can improve quality of care on intensive care units (ICUs), but are infrequently utilized and of varying quality. Knowledge regarding factors that facilitate versus hinder successful implementation of CPs is insufficient and a better understanding of the activities and individuals involved is needed. The aim of this study was to explore the implementation process of CPs within the context of ICUs. Methods An exploratory design with a sequential mixed method was used. A CP survey, including all Swedish ICUs, was used to collect quantitative data from ICUs using CPs (n = 15) and interviews with key informants (n = 10) were used to collect qualitative data from the same ICUs. Descriptive statistics and qualitative content analysis were used, and the quantitative and qualitative findings were integrated. Results The CP implementation was conceptualized according to two interplaying themes: a process to realize the usefulness of CPs and create ...
Health care providers and payers are increasingly turning to clinical pathways as tools to manage the cost of care and promote evidence-based treatment.
novel download clinical pathways in vitreoretinal pages and mesoscopic organs of having called to Join in intrinsically evolutionary germ-line achievements. The survival and number of the indexing 499K)Article was However only comprehensive to the valuable skills evolved on the Murray River is. Yet my wide day at that water was of a tangent of emergency from the discrete-time in its calories to the material involving across its speaking.
Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on managment guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, hematologists, neurologists, intensivists, pharmacists, and nurse practitioners ...
Today, this isolated relationship[ he is speaking of the physician patient relationship] is no longer tenable or possible… Traditional medical ethics, based on the doctor-patient dyad must be reformulated to fit the new mold of the delivery of health care...Regulation must evolve. Regulating for improved medical care involves designing appropriate rules with authority...Health care is being rationalized through critical pathways and guidelines. The primary function of regulation in health care, especially as it affects the quality of medical care, is to constrain decentralized individualized decision making. ...
From IMS Health MIDAS. GPCRs are desirable targets for cancer drugs. GPCRs regulate a broad range of cellular processes that are critical for cancer: cellular proliferation, chemo-resistance, self-renewal, apoptosis, stress signaling, immune evasion, invasion, angiogenesis and metastasis. More specifically, GPCRs regulate the majority of signal transduction pathways that are relevant in cancer cells: EGFR/Ras (proliferation), ATF4/CHOP (cell stress), chemokine (metastasis) and p53 (apoptosis) signaling.. Because GPCRs control and crosstalk with critical pathways, they are frequently hijacked by malignant cells. Systematic analysis of cancer genomes has revealed mutations in GPCRs in about 20 percent of all cancers. Additionally, G proteins are known to be susceptible to genetic alternation, and recent deep sequencing approaches have revealed a high prevalence of hotspot mutations. Although GPCRs are less frequently mutated compared to other oncology pathways and thus have traditionally been ...
Understanding Peripheral Restenosis: Genomic and Proteomic Determinants of Vascular Intervention (PREDICT-PVI) was initiated to gather tissue and data to create a national vascular biobank and improve the success rate of procedures to open blocked arteries in the leg for patients suffering from peripheral artery disease (PAD). Primary treatments used to restore blocked blood flow in PAD (angioplasty, stenting, bypass surgery) have a failure rate as high as 50% within two years. Despite many technical advances, this rate has remained essentially unchanged due to gaps in our understanding about the biology of healing.. The inflammatory response and its resolution are critical to the healing of blood vessels. Excessive scarring of vessels is a common cause of failure of angioplasty, stents, bypass grafts and the arterio-venous fistulas that allow for dialysis. Recent work has identified critical pathways of resolution, including those governed by bioactive lipids derived from omega-3 fatty acids ...
We study the retinal pigment epithelium (RPE), which nourishes and supports the light-sensingphotoreceptors in the retina. The RPE is also the initial site of damage in macular degenerations. How RPE injury leads to vision loss is not yet clear. We use cutting-edge live imaging of healthy and diseased retina along with animal models and advanced cellular and molecular assays to identify early insults that compromise RPE function and can eventually lead to AMD. To gain insight into disease pathogenesis, our research team investigates mechanisms that regulate critical pathways such as autophagy and lysosome function, mitochondrial dynamics, complement-mediated inflammation, and RPE-photoreceptor communication.. ...
I am working on a new approach to painting that is based on an unique pictorial technique I have developed called Overlapping. This process, I believe, is able to open up a novel critical pathways within painting and the perception of pictorial space and its role within the contemporary art thinking. I am interested in creating a series of new artworks capable of symbolizing how the health status of the human body can be emotionally affected and this therefore becomes embodied within a psychosomatic medical disorder. www.stefanialaccu.com/ ...
Chemical atherogenesis is an emerging field that describes how environmental pollutants and endogenous toxins perturb critical pathways that regulate lipid metabolism and inflammation, thus injuring cells found within the vessel wall. Despite growing awareness of the role of environmental pollutants in the development of cardiovascular disease, the field of chemical atherogenesis can broadly include both exogenous and endogenous poisons and the study of molecular, biochemical, and cellular pathways that become dysregulated during atherosclerosis. This integrated approach is logical because exogenous and endogenous toxins often share the same mechanism of toxicity. Chemical atherogenesis is a truly integrative discipline because it incorporates concepts from several different fields, including biochemistry, chemical biology, pharmacology, and toxicology. This review will provide an overview of this emerging research area, focusing on cellular and animal models of disease.
Molecules To Medicine With mTOR Translating Critical Pathways Into Novel Therapeutic Strategies, 2016 (Edited by Kenneth Maiese) Newark, NJ, USA: Elsevier Press ...
SummarySomatic mutation analysis of melanoma has been performed at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last 5 yr, next-generation sequencing (NGS
This is the first multi-site Australian study to include treatment outcomes for alcohol and cannabis users, who represent 70% of treatment seekers in Alcohol and Other Drug services. Results suggest a substantial proportion of clients respond positively to treatment, but that clients with alcohol as …
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If youve had back pain that has gone on for more than a couple of weeks and is starting to affect your work or personal life, speak to your GP. There is a wide choice of treatment pathways and your GP will recommend the one that works best for your situation.. This blog is brought to you by DoctorDoctor who provides access to in-home after-hours medical care for GPs and their patients in Melbourne, Perth, Sydney, and Brisbane.. Medical information published on this website is of a general nature only and not intended to be a substitute for informed healthcare professional advice or clinical care. If you have specific healthcare concerns or issues you should consult with a qualified health care professional such as your own GP.. ...
A study, published in the American Journal of Respiratory and Critical Care Medicine, describes a new treatment pathway for antibiotic resistant bacteria and infectious diseases with benefits for patients and health care providers. Researchers from the University of Birmingham and Newcastle University found that the unusual approach of removing antibodies from the blood stream reduced…
Researchers from Northwestern University have identified a new vulnerability in the SARS-CoV-2s spike protein, illuminating a relatively simple, potential treatment pathway. The spike protein contains the virus binding site which adheres to host cells and enables the virus to enter and infect the body. The researchers discovered a site on SARS-CoV-2 that affects binding to human host cells.. Using nanometer-level simulations, the researchers discovered a positively charged site, known as the polybasic cleavage site, located 10 nanometers from the actual binding site on the spike protein. The positively charged site allows strong bonding between the virus protein and the negatively charged human-cell receptors. The researchers then designed a negatively charged molecule to bind to the positively charged cleavage site. Blocking this site inhibits the virus from bonding to the host cell.. Made up of amino acids, the novel coronaviruss polybasic cleavage sites have remained elusive since the ...
The US Food and Drug Administration has approved Roches diagnostic test for KRAS mutations to help physicians select the most effective treatment pathway for patients with advanced colorectal cancer. - News - PharmaTimes
Scottish prostate cancer patients will now be able to get treatment with Janssens Zytiga much earlier in the treatment pathway, after the Scottish Medicines Consortium had a change of heart and endorsed the drugs use before chemotherapy. - News - PharmaTimes
Autumn 2015 Contents Welcome...1 What we are calling for...2 Background information...3 Better understanding...4 Clear treatment pathways...5 Appropriate diagnosis and reporting...6 Summary of actions
The completion rate of the clinical pathway was 45.6% (115/252). Mean length of stay was 11.7 ± 8.6 (8 - 59 days). Readmission rate was 4.4% (11/252). In multivariate analysis, laparoscopic gastrectomy (odds ratio = 0.511) and subtotal gastrectomy (odds ratio = 5.251) were important factors to fail clinical pathway. Causes of failure for clinical pathway were intra-abdominal complications (32.8%), patient factors (29.9%) and wound complications (21.9%). ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
This paper demonstrates that data-driven clinical pathways can be developed using electronic health record data to facilitate innovations in practice-based care delivery for chronic disease management.
Jang DH, Jo YH, Lee JH, et al. Moderate to severe hyperphosphataemia as an independent prognostic factor for 28-day mortality in adult patients with sepsis. Emerg Med J. 2020;37(6):355-361. doi:10.1136/emermed-2019-208976. Dean DJ, Sabagha N, Rose K, et al. A Pilot Trial of Topical Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome [published online ahead of print, 2020 Jun 22]. Acad Emerg Med. 2020;10.1111/acem.14062. doi:10.1111/acem.14062. Kline JA, VanRyzin K, Davis JC, et al. Randomized Trial of Therapy Dogs Versus Deliberative Coloring (Art Therapy) to Reduce Stress in Emergency Medicine Providers. Acad Emerg Med. 2020;27(4):266-275. doi:10.1111/acem.13939. Contact Settings and Risk for Transmission in 3410 Close Contacts of Patients With COVID-19 in Guangzhou, China: A Prospective Cohort Study. Ann Intern Med. 2020 Aug 13. doi: 10.7326/M20-2671. Online ahead of print.. HEART Pathway Implementation Safely Reduces Hospitalizations at One Year in Patients With Acute Chest ...
St John of God Midland Public and Private Hospitals has recently undertaken a review of public general medical outpatient clinics and sub-specialties and referral pathways.. This will help SJOG to meet the ongoing and high demand of urgent patient admissions, Emergency Department referrals and those with significant clinical morbidity.. The criteria to accept referrals via the Central Referral Service (CRS) has been updated for the following services, effective immediately:. • Cardiology. • Endocrinology and diabetes. • General medicine. • Infectious disease. • Neurology. • Renal Medicine. GPs will be provided with the names of patients who are currently on a waitlist that do not meet the new criteria. In addition, patients will also be informed of this change and advised to discuss alternative options with their GP. Effective immediately, non-urgent referrals should be referred to the CRS.. For a patient requiring immediate attention or advice, GPs should please call our GP Priority ...
Emergency Clinical Pathways (ECP) for stroke have never been tested in randomized controlled trials (RCTs). To evaluate the effectiveness of an ECP for stroke patients in Latium (Italy) emergency system. cluster-RCT designed to compare stroke patient referrals by Emergency Medical Service (EMS) and Emergency Room (ER) health professionals trained in the ECP, with those of non-trained EMS and ER controls. Primary outcome measure was the proportion of eligible (aged ≤ 80 and symptom onset ≤ 6 hours) stroke patients referred to a stroke unit (SU). Intention to treat (ITT) and per-protocol (PP) analyses were performed, and risk ratios (RR) adjusted by age, gender and area, were calculated. 2656 patients in the intervention arm and 2239 in the control arm required assistance; 78.3% of the former and 80.6% of the latter were admitted to hospitals, and respectively 74.8% and 78.3% were confirmed strokes. Of the eligible confirmed strokes, 106/434 (24.4%) in the intervention arm and 43/328 (13.1%) in the
The Complete Denture: A Clinical Pathway,2e Author(s): Michael I. MacEntee Date: 2014 Format: PDF Language: English https://www.nitroflare.com/view/4C2E7D5
The new data thus adds depth to our understanding of things that go awry in these critical pathways, sometimes promoting cancer formation, other times providing cancer cells with advantages that enable them to crowd out healthy cells, comments Dr. Tuveson, who in addition to leading a lab at CSHL is the Director of CSHLs NCI-designated Cancer Center and Director of Research for the Lustgarten Foundation, the nations largest philanthropic funder of pancreatic cancer research. The cell adhesion pathway affected by newly discovered mutations in gene promoter regions is important for obvious reasons in cancer: cancer cells want to grow and proliferate, a process that can culminate in their migration from their tissue of origin. Once they have broken free, they can travel via the bloodstream to other places in the body, a process called metastasis that is often responsible for cancer fatalities. The axon guidance pathway associated with promoter mutations has a less obvious but no less important ...
The researchers conclude the combination of a ferroptosis sensitizer and checkpoint inhibitor creates a strong immune response that fights the tumor by causing ferroptosis. In cancer patients treated with immunotherapy, signs of ferroptosis correlated to the benefits from therapy.. If ferroptosis is a critical pathway, we may be able to sensitize it to further stimulate immunotherapy or overcome resistance to immunotherapy, Zou says. We need to understand this better and work out different mechanisms.. This is the initial step, and Zou cites many questions that need to be explored and understood before any treatment moves forward.. Immunotherapy is effective in only about 30 percent of cancer patients. Our findings provide new insights to understand and explore how to make the immune system work for more patients, Zou says.. -. Disclosure: The University of Michigan has applied for patent protection and is seeking commercialization partners for this technology.. ...
University at Buffalo researchers have identified a neural pathway that could hold a key to preventing relapse in individuals recovering from cocaine addiction. Their study focused on the activity of Activin receptors in the brain that are located in regions involved in pleasure and reward.. Published online June 1 in Nature Neuroscience, the study authored by Amy Gancarz, PhD, found that the Activin pathway controls the ability of cocaine to alter the connections between various neurons. By manipulating the activity of Activin receptors, researchers were able to change cocaine-taking behavior in animal models.. Understanding this critical pathway will help us pursue new directions in potential pharmacological and gene therapies to prevent drug relapses, senior author David Dietz, PhD, assistant professor at the university medical schools Department of Pharmacology and Toxicology, said in a June 18 news release.. ...
Genetics has allowed medicine to move beyond treating symptoms and start treating the underlying causes of disease.. No diseases are hopeless anymore, says Dr. Hayden. The way I see them is that their secrets have just not yet been identified.. Dr. Haydens work focuses on understanding the genetic roots of illness and using that understanding to develop better approaches to treatment for patients. He researches diabetes, coronary artery disease, and is part of a large collaboration to determine the genetic basis for adverse drug reactions in children. Much of his career has also been dedicated to understanding the development of Huntington disease and finding a way to cure it.. When we started working on Huntington disease, the future was dark and patients and families felt hopeless, says Dr. Hayden. Today, that has all changed.. Researchers in the Hayden laboratory have found a critical pathway in the development of juvenile forms of Huntingtons disease. Blocking the action of ...
Figure 2: Parsley (dried). Apigenin May Assist in the Prevention of Cancer. Apigenin has been shown to possess remarkable anti-carcinogenic properties. 3 There has been significant progress in studying the biological effects of apigenin at cellular and molecular levels as a chemopreventive agent. 4 There are a number of biological effects of apigenin in numerous mammalian systems in vitro as well as in vivo, due to its low intrinsic toxicity and because of its striking effects on normal versus cancer cells. 5 The exact mechanism of apigenin is still being researched, but the current research demonstrates that apigenin affects several critical pathways and/or targets:. ...
For those that view cellular signaling as a tangled mass of cooked spaghetti, a guidebook that introduces shared principles, highlights typical behaviors, and provides clear examples of the uses for these critical pathways should be invaluable. This book provides all of that and more. But it also, perhaps inadvertently, highlights overly reductionist concepts of cellular control. Hopefully, this tome will close the book on that mode of thought and stimulate a new generation to think about and understand how cellular regulation is so tightly integrated-because this is the key to more effective treatments for disease.. ...
Parasites such as Toxoplasma gondii invade host cells, replicate and then must exit to find new host cells to invade. Traveling outside their host cell exposes the parasites to environmental stresses that limit how long they can remain viable while searching for new host cells.. The researchers found that the parasite triggers a stress response mechanism that alters protein production through phosphorylation of a factor called eIF2, which the Toxoplasma parasite uses to survive periods when it finds itself without a host cell. Phosphorylation is a cellular process in which a phosphate compound is added to a protein to alter its activity.. Toxoplasma does not like to be homeless, said William J. Sullivan Jr., Ph.D., associate professor of pharmacology and toxicology. Being deprived of the nutrients and shelter provided by the host cell is a serious stress on the parasite. Our research uncovered a critical pathway the parasite uses to survive the journey from one host cell to another.. The ...
Audio: In the first week or two following a stroke the orthoptist will assess the patient for presence of an ocular condition, diagnosis of the type of ocular condition and whether the ocular defects are due to the recent stroke or pre-existing pathology. Image: Video of Orthoptist Audio: To determine presence of any ocular related […]. ...
At LiDCO, we like to send emails about hemodynamic monitoring. Our emails take the form of educational blogs, new product launches and other closely related announcements.. We do our best to ensure that our emails are highly relevant to the recipient e.g its likely we wont send you clinical demonstrations if you work in administration.. You can unsubscribe at any point through our unsubscribe link in every email we send. We will also remove your details from our system by simply emailing to [email protected] We will never ask you for personal details that arent relevant to our connection with you e.g we wont ask, what school did you go to?. Click here to sign up to our newsletter. ...
On the 28th January 2015, the latest presentation in Gedes Mental Health Dialogue Programme was focused on relating behavioral change with mental health. Over 20 attendees listened to the presentation given by Professor Andrew Zamani, Dean of the Social Science Faculty at Nasarawa State University and currently President of the Association of Psychologists in Nigeria.. Professor Zamani highlighted the roles of behavior change in achieving mental health through the following lenses: conceptual issues, diagnostic criteria, consequences of mental impairment and behavior change imperatives.. It was noted during the session that, in promoting mental health, intervention indices should go beyond the cultural and scientific definitions of abnormal behaviors which are mostly symptom-based, but include enhancement of protective factors and promotion of healthy lifestyle in addition to effective treatment pathways. His presentation was followed by a lively Q and A session. Gedes next Mental Health ...
Interviews with authors of articles from JAMA Oncology. JAMA Oncology is the definitive journal for scientists, clinicians, and trainees in the field of oncology worldwide. Our original, innovative, and timely scientific and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for our readers. JAMA Oncology aims to effectively convey the findings of important clinical research, major scientific breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community. Our goal is that successful communication of new knowledge will ultimately translate to clinical benefit for people living with and surviving cancer.
Our endometriosis clinic at Chelsea and Westminster sees patients from all over the country, many of whom have been referred from their GP because they require a specialist opinion. We work with a variety of people, including those awaiting diagnosis or others who may have a long history of the condition.. On your first visit, its likely that you will be seen by a specialist nurse who will take a detailed history from you and ask about any medications you may be taking or any previous operations you may have had - it would be helpful, although not essential, if you can bring information on either of these with you on the day. If further investigations are required, the nurse will also arrange these for you.. Following this you will be invited back to the clinic to see one of our doctors; sometimes you may see a gynaecology registrar if a consultant is not available. We offer very clear treatment pathways for people affected by endometriosis; sometimes this may mean surgery but can also involve ...
Some brand names of eye drops have been included in brackets for information, but please always prescribe eye drops generically.. Note: The Northern (NHS) Treatment Advisory Group does not recommend the use of high-dose vitamin and mineral supplements in the prevention of progression of AMD.. Note: The Northern (NHS) Treatment Advisory Group recommends the sequential pharmacological management of MO secondary to RVO as per the North East Retina Group (NERG) RVO treatment pathway.. CD&D APC Patient Decision Aids Resource available at: http://medicines.necsu.nhs.uk/guidelines/durham-darlington/. CD&D APC Do Not Prescribe List and Grey List - drugs prescribed under limited circumstances available at: http://medicines.necsu.nhs.uk/guidelines/durham-darlington/. ...
The American Association for Cancer Research (AACR) began publishing scientific articles in 1916, and now proudly publishes eight peer-reviewed journals which cover a diverse array of cancer-related topics. The editors from these esteemed journals identify one must read article from each issue, and their picks for the month of August are highlighted below. These featured articles are freely available for a limited time.. Journal: Cancer Epidemiology, Biomarkers & Prevention. A Review of Prostate Cancer Genome-Wide Association Studies (GWAS). This review outlines findings from over 40 prostate cancer genome-wide association studies (GWAS), which have identified approximately 170 common variants. The authors discuss GWAS in non-European populations, GWAS from patients who have received long-term radiotherapy, and the use of common variants to guide a personalized treatment pathway. Furthermore, the authors suggest how this information may be utilized to facilitate the screening and management of ...
Washington, DC-The institution of cancer treatment pathways is not incompatible with personalized medicine, but rather it has the potential to offer access to a rapid learning system that can promote personalized therapy, said Michael Kolodziej, MD, National Medical Director, Oncology Solutions, Aetna, at the Fifth Annual Conference of the Association for Value-Based Cancer Care.
We conducted a retrospective cohort study based on a case note review to determine whether there are differences in the treatment pathways followed for men and women admitted with acute myocardial ischemia and infarction after adjusting for differences in case mix. Women were as likely as men to receive thrombolysis, but were less likely...
Download and Read online Gluten Related Disorders: Diagnostic Approaches, Treatment Pathways And Future Perspectives, ebooks in PDF, epub, Tuebl Mobi, Kindle Bo
Just over a quarter of women (28.7%) with DI3 between 0.876 (90% sensitivity) and 0.803 (90% specificity) thresholds would require an additional examination by axial DXA to verify their diagnosis. Of these women, 82.5% had an osteopenic/osteoporotic T-score at either the femoral neck or total hip.. About a third of women (32.6%) of women with DI1 between the upper and lower thresholds (0.844 and 0.779, respectively) would require an additional DXA.. DXA examinations needed with FRAX(BMI) would include 57.0% of this cohort of women, whereas the ultrasound approach would reduce the percentage of women requiring DXA to 16%.. The present thresholds for the application of DI to current osteoporosis management pathways show promise for the technique to decrease the amount of DXA referrals and increase diagnostic coverage, the researchers conclude. However, these results need to be confirmed in future studies.. Optimally in the future, decisions to treat or not could be based on ultrasound ...
Disclaimer: The information and data in this document (Information) is based on scientific evidence current as of the date issued and is subject to change without notice. The Information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Any person consulting or applying the Information is expected to use independent medical judgment and expertise in the context of individual clinical circumstances. Winnipeg Regional Health Authority and the Manitoba Renal Program make no representation or guarantees of any kind whatsoever regarding the content or use or application of the Information and specifically disclaim any responsibility for its application or use in any way. ...
醫院之臨床路徑:醫院的決策制定已經從以意見為基礎轉而尋求以合理的科學證據為依歸。這樣的決策制定被視為是以臨床證據為基礎的執行臨床業務方式。由於新證據不斷的出刊發表,加上日常業務的要求,因此對於醫事人員來說,很難不斷地更新證據。臨床路徑是一個以文件記錄為基礎的工具,將可得的最佳證據與臨床實務之間連結。它們針對特定的症狀以或介入措施提供了建議、流程以及時程。臨床路徑已經被廣泛的運用,但是在許多單一的試驗當中,它的影響結果卻是矛盾不一致的。這篇文獻回顧的目的在總結臨床路徑對於臨床人員執行業務 (如文書品質) 、病人結果 (如死亡率、併發症) 、住院天數以及醫院成本的證據並且評估其影響。 ...
Use of active surveillance for very low-risk prostate cancer rose 15.7% over a 3-year span and continues to rise, but rates are still low.
Pelatihan PONEK - Pelatihan FKTP - Pelatihan MFK - Pelatihan PPGDON - Pelatihan APN - Pelatihan IPCN - Pelatihan Geriatri - Pelatihan Asesor - Pelatihan Case Manajer - Pelatihan Clinical Pathway. Pelatihan PONEK 2020, Pelatihan PONED 2020, Pelatihan Keperawatan 2020, Pelatihan Asesor Perawat, Pelatihan Asesor Bidan, Pelatihan Geriatri 2020, Pelatihan PPI 2020, Pelatihan IPCD 2020, Pelatihan MFK, Pelatihan Asesor Keperawatan, Pelatihan Asesor Bidan 2020, Pelatihan Geriatri, Pelatihan PPI, Pelatihan IPCD, Pelatihan IPCN, Pelatihan Humas Dan Marekting Rumah Sakit, Pelatihan ANJAB, Pelatihan PMKP, Pelatihan HIV Dan AIDS, Pelatihan FKTP, Pelatihan EWS, Pelatihan IPAL, Pelatihan, Pelatihan Kredensial Rumah Sakit, Pelatihan Case Manager, Pelatihan Clinical Pathway, Pelatihan Arsip Elektronik Rumah Sakit, Pelatihan Arsip Elektronik Pemda, Pelatihan Gerontik, Pelatihan APN, Pelatihan HDP, Pelatihan K3 Rumah Sakit, Pelatihan Koding, Pelatihan Gizi Rumah Sakit, Pelatihan Kepala Bidang Keperawatan, ...
Pelatihan PONEK - Pelatihan FKTP - Pelatihan MFK - Pelatihan PPGDON - Pelatihan APN - Pelatihan IPCN - Pelatihan Geriatri - Pelatihan Asesor - Pelatihan Case Manajer - Pelatihan Clinical Pathway. Pelatihan PONEK 2020, Pelatihan PONED 2020, Pelatihan Keperawatan 2020, Pelatihan Asesor Perawat, Pelatihan Asesor Bidan, Pelatihan Geriatri 2020, Pelatihan PPI 2020, Pelatihan IPCD 2020, Pelatihan MFK, Pelatihan Asesor Keperawatan, Pelatihan Asesor Bidan 2020, Pelatihan Geriatri, Pelatihan PPI, Pelatihan IPCD, Pelatihan IPCN, Pelatihan Humas Dan Marekting Rumah Sakit, Pelatihan ANJAB, Pelatihan PMKP, Pelatihan HIV Dan AIDS, Pelatihan FKTP, Pelatihan EWS, Pelatihan IPAL, Pelatihan, Pelatihan Kredensial Rumah Sakit, Pelatihan Case Manager, Pelatihan Clinical Pathway, Pelatihan Arsip Elektronik Rumah Sakit, Pelatihan Arsip Elektronik Pemda, Pelatihan Gerontik, Pelatihan APN, Pelatihan HDP, Pelatihan K3 Rumah Sakit, Pelatihan Koding, Pelatihan Gizi Rumah Sakit, Pelatihan Kepala Bidang Keperawatan, ...
Neutropenic sepsis is a potentially life-threatening complication of chemotherapy and has an associated mortality of 2% to 21%. Patients can deteriorate rapidly and are usually advised to attend their local emergency department (ED) for urgent assessment and antibiotic therapy within one hour of arrival. Delivery of this emergency care is, however, inconsistent, and at times suboptimal, due to a lack of awareness of the condition and of clinical expertise. This article discusses a collaborative project between an acute oncology service and an ED, which has improved and sustained compliance with this standard through a range of initiatives, including revised and integrated sepsis guidelines, education, sepsis champions and a fast-track patient pathway ...
This module will provide students with an opportunity to develop the skills and attitudes needed to be a healthcare science practitioner. Learning is centred on patient presentation and common patient pathways through the health service. Clinical placements will contextualize learning, offer real-life experience and enable students to apply taught professional practice outcomes in order to practise safely. Students will begin a portfolio of evidence and will be required to complete specified sections of the professional training manual.. ...
Making diabetes management effective - the principle aim of the integrated diabetes management program of the hospital. Aimed at combating the menace of diabetes in India, Apollo group of hospitals will launch 100 Sugar Clinics around the country in 90 days. These clinics will manage the life cycle of a diabetic and work towards minimizing the associated morbidity and mortality. These clinics working on a specifically developed clinical pathway will offer standardized care to the diabetic
And this is just hypertension - a single, if important, condition. Consider how much more there is to remember across all of the major conditions.. The second reason why its hard for GPs to take on more specialist management (what I have called level 3 of what we know about a condition) is that specialists will be reluctant to let them do so. Specialists rely on their training to interpret what they see and make decisions. If the future model of care relies on them letting less-specialised colleagues perform what was their duties there will be an understandable degree of discomfort, if not open resistance.. I used to be the Medical Director of Map of Medicine, a company that produces clinical pathways to help local communities design services. I met countless local leaders - managers and clinicians - that wanted to redesign pathways so that GPs handled more patient care. The prevailing view seemed to be that by putting the information into a pathway, GPs would know what to do and ...
The first difference is that we do not produce a single product or service. Every patient is different, and every patient expects and deserves personalized service and individualized attention. Not so different, you might argue. There are plenty of businesses that offer service tailored to the individual, and they have learned how to provide that service consistently and efficiently. And it is true that, in medicine, there are general rules and appropriate clinical responses for many patients with one or another disease. For example, I have discussed below the use of clinical pathways to make care decisions more routine, and I have discussed protocols that can be used to avoid ventilator-associated pneumonia, central line infections, and other harm. But, at its core, effective treatment really does require due attention to the individual biology of the patient, his or her state at the exact time of treatment, as well as related factors like family and home situations. It is as much art as science ...
The first difference is that we do not produce a single product or service. Every patient is different, and every patient expects and deserves personalized service and individualized attention. Not so different, you might argue. There are plenty of businesses that offer service tailored to the individual, and they have learned how to provide that service consistently and efficiently. And it is true that, in medicine, there are general rules and appropriate clinical responses for many patients with one or another disease. For example, I have discussed below the use of clinical pathways to make care decisions more routine, and I have discussed protocols that can be used to avoid ventilator-associated pneumonia, central line infections, and other harm. But, at its core, effective treatment really does require due attention to the individual biology of the patient, his or her state at the exact time of treatment, as well as related factors like family and home situations. It is as much art as science ...
In November 2016, NICE reviewed this guidance and recommended that it should be withdrawn. The guidance was published in June 2011 and recommended that further research was carried out on the technology. There was insufficient evidence on its use in clinical practice to recommend adoption. On reviewing the guidance in 2016, NICE determined that: The comparator in the original guidance, standard serial troponin testing, was changed in 2014 to high sensitivity troponin testing which expert advice indicated is now widespread in the NHS The clinical pathway in the original evaluation has significantly changed and the original scope is no longer valid. These changes mean that the current guidance is no longer valid and NICE would not be able to update it. The guidance has therefore been withdrawn. For a copy of the review decision please contact [email protected] ...
Neutropenic sepsis is a medical emergency - these patients need immediate assessment and initiation of treatment.. Clinical pathway for neutropenic sepsis. Antibiotic Treatment. Antifungal Treatment. ...
Critical Pathways in Cardiology. 5 (4): 187-90. doi:10.1097/01.hpc.0000249784.29151.54. PMID 18340236. Pearson, T. A. (2007). " ...
Critical Pathways in Therapeutic Intervention. Missouri: Mosby Inc. p. 262. ISBN 0-323-00105-X. "Nerve Injury (Neuropraxia, ...
Cannon C, O'Gara P (2007). Critical Pathways in Cardiovascular Medicine (2nd ed.). Lippincott Williams & Wilkins. p. 243. ... There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity ...
Critical Pathways in Cardiology (10): 44-45. "UOTW #14 - Ultrasound of the Week". Ultrasound of the Week. 20 August 2014. ...
Pathways Listening, Speaking, and Critical Thinking by MacIntyre. Douglas, Scott R. Academic Inquiry: Writing for Post- ... Robert Lowth (26 March 1794). A Short Introduction to English Grammar: With Critical Notes. Printed for J.J . Tourneisin - via ...
Barzilai, N; Huffman, DM; Muzumdar, RH; Bartke, A (June 2012). "The critical role of metabolic pathways in aging". Diabetes. 61 ... 2018). "Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older ... "Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans". PLoS Biol. 4 (4): e113. doi:10.1371/journal. ...
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The second pathway, is called the direct (or Go) pathway and is excitatory. This pathway inhibits the GPi, resulting in the ... Two pathways emerge from the striatum. One pathway is called the indirect (or NoGo) pathway and is inhibitory. This projects to ... As of 2013 there was intense debate with regards to division of the circuit, pathway interactions, number of pathways and ...
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The motor and oculomotor pathways are sometimes grouped into one motor pathway.) The five general pathways are organized as ... The short indirect pathway has been proposed to, in a direct push pull antagonism with the direct pathway, close the gate to ... However the speed of the direct pathway would not be concordant with the indirect pathway in this model leading to problems ...
The indirect pathway also receives excitatory input from various brain regions. Indirect pathway medium spiny neurons project ... Dopamine plays critical roles in the regulation of psychomotor functions in the brain (Bromberg-Martin et al., 2010; Cools, ... However, direct pathway medium spiny neurons mostly signal sequence initiation/termination and indirect pathway medium spiny ... D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. Most striatal MSNs contain only D1-type or D2-type ...
Juliet J. Fall: Reading Claude Raffestin: pathways for a critical biography. In: Environment and Planning D: Society and Space ...
Smith appears on the albums Critical Mass (2005) and Pathways (2009). In 2017, he released his first album as leader, Kinfolk: ... 1 (ArtistShare, 2014) More Than Meets the Ear (ArtistShare, 2015) With Dave Holland Critical Mass (Dare2, 2006) Pathways (Dare2 ...
A number of specific decay pathways exist that recognize aberrant messages and promote their decapping. Nonsense mediated decay ... Critical Reviews in Biochemistry and Molecular Biology. 39 (4): 197-216. doi:10.1080/10409230490513991. PMID 15596551. Deana, ... Meyer, Sylke; Temme, Claudia; Wahle, Elmar (January 2004). "Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes". ...
Hence binding site on protein are critical parts of signal transduction pathways. Types of ligands include neurotransmitters, ... Its regulation in glycolysis is imperative because it is the committing and rate limiting step of the pathway. PFK also ... This regulation efficiently conserves glucose reserves, which may be needed for other pathways. Citrate, an intermediate of the ... Binding sites incur functional changes in a number of contexts, including enzyme catalysis, molecular pathway signaling, ...
Chung, DC (2000). "The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis". Gastroenterology ... Both the β-catenin gene and the APC gene are involved in the same cell growth signalling pathway, but the APC gene is known to ...
Cilia defects adversely affect numerous critical developmental signaling pathways essential to cellular development. Other ...
A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066X.58.1.53 ... A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066x.58.1.53 ... Evidence suggests that religiosity can be a pathway to both mental health and mental disorder. For example, religiosity is ...
"A critical role for the mTORC2 pathway in lung fibrosis". PLOS ONE. 9 (8): e106155. Bibcode:2014PLoSO...9j6155C. doi:10.1371/ ... The mTORC2 pathways plays a crucial role in pathogenesis of lung fibrosis , and inhibitors of its active site such as ... Studies using mice with tissue-specific loss of Rictor, and thus inactive mTORC2, have found that mTORC2 plays a critical role ... Mendoza MC, Er EE, Blenis J (June 2011). "The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation". Trends in ...
... a critical enzyme in the cholesterol biosynthesis pathway". Clin. Genet. 75 (1): 19-29. doi:10.1111/j.1399-0004.2008.01099.x. ... The core biosynthetic route is via a polyketide synthase pathway from 10 acetates, 4 methyls of methionines, 1 succinate, and 1 ...
A number of critical developmental signaling pathways essential to cellular development have been discovered. These are ... Signal transduction pathways involved include the Hedgehog signaling pathway and the Wnt signaling pathway. Dysfunctional cilia ... Cilia may thus be "viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes ... cilia are critical for: development homeostasis reproduction "Just as different genes can contribute to similar diseases, so ...
The cilia defects adversely affect "numerous critical developmental signaling pathways" essential to cellular development. The ...
Mundinano, Inaki (2018). "Transient visual pathway critical for normal development of primate grasping behavior". Proceedings ... Berman R.; Wurtz R. (2011). "Signals conveyed in the pulvinar pathway from superior colliculus to cortical area mt". The ...
A Critical Review of Nitrogenous Disinfection Byproduct Formation Pathways". Environmental Science & Technology. 46 (1): 119- ...
The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well ... In 2011, it was demonstrated that the methylation of mRNA plays a critical role in human energy homeostasis. The obesity- ... These newly constructed networks function very efficiently via new pathways as soon as drugs of abuse are further taken ... In ... In the original sense of this definition, epigenetics referred to all molecular pathways modulating the expression of a ...
This meant that it affected the activation of both pathways and plays a critical role. The other two amino acids which were ... Y1493.50 still activated both PKC and ERK1/2 suggesting that they did not play a critical role in the activation of the pathway ... The receptor cannot activate the PKC but it can still activate the ERK1/2 pathway although it is a little bit slower. There ... The mutated D972.50 receptor could not activate PKC nor could it activate the ERK1/2 pathway. ...
There is an interesting and critical difference in the coenzymes used in catabolic and anabolic pathways; in catabolism NAD+ ... The Entner-Doudoroff pathway is a glycolytic pathway that is considered the second pathway used for carbohydrates used by ... the pentose phosphate pathway and the Entner-Doudoroff pathway. The Embeden-Meyerhof pathway and the Krebs cycle are the centre ... Doudoroff pathway The cell determines whether the amphibolic pathway will function as an anabolic or catabolic pathway by ...
A single genetic locus, however, critical in early eye movement control pathways on chromosome 13q31-q33 has been discovered. ... Researchers surmise, therefore, that there exists a gene critical to establishing early eye movement control pathways. ... a family examination demonstrating similar symptoms is critical in order to prevent a misdiagnosis. A person afflicted with ...
However, when the prediction rule is implemented as part of a critical pathway, so that a hospital or clinic has procedures and ... Marrie TJ, Lau CY, Wheeler SL, Wong CJ, Vandervoort MK, Feagan BG (2000). "A controlled trial of a critical pathway for ...
Critical role for Fat/Hippo and IIS/Akt pathways downstream of Ultrabithorax during haltere specification in Drosophila. ... Studying Drosophila melanogaster (commonly known as fruit fly) as a model, he elucidated the molecular pathways Wnt, TGF-? and ...
... the Critical Step in the Pathway to Fusion Energy". Fusion Science and Technology. 68 (2): 225-236. doi:10.13182/FST14-953. ... The stability of structural materials in all nuclear reactors is a critical issue. Materials that can survive the high ... along a diversity of technology pathways, such as the UK Spherical Tokamak for Energy Production, within the 2030-2040 time ...
... involving wild-type and TRIF-deficient mice are critical for understanding the coordinated responses of TLR pathways. It is ... Toll-like receptor signaling pathway - Reference pathway (KO) from the KEGG website. TRIF+protein,+human at the US National ... 7(1) 12-19 Ouyang X, Negishi H, Takeda R, Fujita Y, Taniguchi T, Honda K (2007). "Cooperation between MyD88 and TRIF pathways ... Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response ...
Therefore, one way in which not exercise induces an increase in muscle mass is to down regulate the pathways which have the ... The branched-chain amino acids or BCAAs (leucine, isoleucine, and valine) are critical to this process, in addition to lysine ... The particular protein degradation pathway which seems to be responsible for much of the muscle loss seen in a muscle ... Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - ...
PET technology can be used to trace the biologic pathway of any compound in living humans (and many other species as well), ... Laruelle, M (2000). "Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review". ...
"First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health ... dysfunctional bleeding and clotting commonly seen in EVD has been attributed to increased activation of the extrinsic pathway ...
Synaptic inhibition is critical for allowing the pre-Bötzinger complex to communicate with other respiratory centers in order ... or inhibit the NALCN channels depending on the neurotransmitter that binds the receptor and the specific signaling pathway that ... Serotonin plays a critical role in altering the pacemaker neurons involved in gasping and normal respiratory activity. Blocking ... The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs ...
Different emetic pathways exist, and substance P/NK1R appears to be within the final common pathway to regulate vomiting.[36] ... "American Journal of Respiratory and Critical Care Medicine. 163 (3 Pt 2): S18-21. doi:10.1164/ajrccm.163.supplement_1.2011113. ... Because these regions are related to complexed signal transduction pathways mediated by cytokines, it has been proposed that ... "Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor". Molecular Biology of the ...
The zones were interconnected with moving pathways.[27] Architectural circle[edit]. Congrès International d'Architecture ... Frampton, Kenneth (1990) [1980]. Modern Architecture a Critical History (Revised and enlarged ed.). London, United Kingdom: ...
β-catenin of the canonical Wnt signalling pathway plays a role in cell fate determination, as it is critical for ... Knock out of the entire pathway results in early embryonic death, therefore most research of this nature utilised conditional ... Loss of the regulator, Pten, of the Phophatidylinositol3' kinase pathway results in skeletal overgrowth and growth plate ... However the exact mechanism and signalling pathways are still unclear. Studies have shown that embryonic stem cells are more ...
... neurotransmitter pathway, metabolic pathway, blood flow, or other), and a radionuclide (usually either a gamma-emitter or a ... and some are specialized in critical medicine. ...
El Murr, N.; Sheats, J. E.; Geiger, W. E.; Holloway, J. D. L. (1979). "Electrochemical Reduction Pathways of the Rhodocenium ... The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle ...
... rewards triggers high levels of activation in neurohormonal pathways that, cumulatively, are thought to exert adverse effects ...
In July and November 1989, Nature published papers critical of cold fusion claims.[55][56] Negative results were also published ... Only about one in one million of the intermediaries decay along the third pathway, making its products comparatively rare when ... Mostly in the 1990s, several books were published that were critical of cold fusion research methods and the conduct of cold ... The products formed via these decay pathways are:. 4He* → n + 3He + 3.3 MeV (ratio=50%). 4He* → p + 3H + 4.0 MeV (ratio=50%). 4 ...
"North Atlantic Right Whale Source Document for the Critical Habitat Designation: A review of information pertaining to the ... Cranford, T.W.; Krysl, P.; Hildebrand, J.A. (2008). "Acoustic pathways revealed: simulated sound transmission and reception in ... definition of "critical habitat"". NOAA Fisheries. July 2014.. *. Laidre, K. L.; Stirling, I.; Lowry, L. F.; Wiig, Ø.; Heide- ...
Organisations opposed to euthanasia,[14][15] as well as some supporting euthanasia, are critical of Nitschke and his methods.[ ... he posed a serious risk because people may elect to commit suicide believing it to be a pathway sanctioned by a medical ...
Wnt signaling pathway[edit]. Wnt signaling pathway has been shown to be involved in several critical steps in embryogenesis and ... Notch signaling pathway[edit]. In Notch signaling, critical proteolytic reactions takes place during maturation and activation ... These evidences collectively suggest a critical role of presenilin 1 in the Notch signaling pathway. ... canonical Wnt signaling pathway. • dorsal/ventral neural tube patterning. • neural retina development. • positive regulation of ...
The CNS regulates the immune system through neuroendocrine pathways, such as the HPA axis. The HPA axis is responsible for ... There may be a critical period during development during which the level of stress hormones in the bloodstream contribute to ... Macrì S, Würbel H (December 2006). "Developmental plasticity of HPA and fear responses in rats: a critical review of the ... Maintenance of the SHRP period may be critical for HPA development, and the extreme stress of maternal separation, which ...
The breast cancer susceptibility protein BRCA2 and PALB2 controls the function of Rad51 in the pathway for DNA repair by ... "The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment". Proceedings of ... by the HRR RAD52-RAD51 back-up pathway[14]) to compensate for the added DNA damages remaining when BRCA1 was deficient.[12][13] ... "Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer ...
The different photosynthesis pathways used by C3 and C4 plants cause them to discriminate differently towards 13C The C4 and C3 ... Some archaeologists advocate a more holistic approach to bioarchaeology that incorporates critical theory and is more relevant ... The three photosynthesis pathways are C3 carbon fixation, C4 carbon fixation and Crassulacean acid metabolism. C4 plants are ... Corn, millet and sugar cane are some well-known C4 domesticates, while all trees and shrubs use the C3 pathway. C3 plants are ...
... uses of test statistics are themselves open to critical analysis,[161] although critical commentary on papers in economics in ... Towards a Green Economy: Pathways to Sustainable Development and Poverty Eradication (PDF) (Report). United Nations Environment ... Hunt, E. K. (2002). History of Economic Thought: A Critical Perspective. M.E. Sharpe. p. 36. ISBN 978-0-7656-0606-8. .. ... Adam Smith (1723-1790) was an early economic theorist.[37] Smith was harshly critical of the mercantilists but described the ...
A fifth pathway of carbon fixation". Science. 318 (5857): 1732-3. doi:10.1126/science.1152209. PMID 18079388.. ... Methanogens also play a critical role in the carbon cycle, breaking down organic carbon into methane, which is also a major ... Romano A; Conway T (1996). "Evolution of carbohydrate metabolic pathways". Res Microbiol. 147 (6-7): 448-55. doi:10.1016/0923- ... Most of the metabolic pathways, which are the object of the majority of an organism's genes, are common between Archaea and ...
Anderson, Pamela Sue; Clack, Beverley (eds.) Feminist Philosophy of Religion: Critical Readings (London: Routledge, 2004) ISBN ...
H3K36me3 has the ability to recruit the MSH2-MSH6 (hMutSα) complex of the DNA mismatch repair pathway.[96] Consistently, ... Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM (2000). "A critical role for histone H2AX in ... "A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin". Genes & Development. 18 (11): ...
Multiple pathways for the conversion of different biofuel feedstocks are being used. In the next few years, the cost data of ... The selection of land on which to grow the feedstocks is a critical component of the ability of biofuels to deliver sustainable ...
... they showed that both pure monetary rewards and charitable donations activated the mesolimbic reward pathway, a primitive part ... Critical rationalism. *Experimental philosophy. *Falsificationism. *Foundationalism / Coherentism. *Generative linguistics. * ...
at the American Association of Critical-Care Nurses website. *^ Orozco-Gutierrez A, Rojas-Cerda L, Estrada RM, Gil-Rosales C ( ... Nov 2001). "Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose". ... Critical Care Medicine. 31 (3): 960-7. doi:10.1097/01.ccm.0000053643.21751.3b. PMID 12627012.. ...
Language learning motivation: pathways to the new century (Google Book). Retrieved 2012-01-27.. ... Dawes, Robyn (2004). "Time for a critical empirical investigation of the MBTI: Case and Phillipson are right to highlight the ... Supporters of the "projective" approach to personality assessment are critical of the "structured" approach because defense ... It has been argued that this reflects a lack of critical scrutiny.[40] Many of the studies that endorse MBTI are ...
Newgard CB, Hwang PK, Fletterick RJ (1989). "The family of glycogen phosphorylases: structure and function". Critical Reviews ... metabolic pathway. PRIAM. profile. PDB structures. RCSB PDB PDBe PDBsum. Gene Ontology. AmiGO / QuickGO. ...
... ether phospholipids critical for the normal function of mammalian brains and lungs.[4] They also contain approximately 10% of ... "A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defense". Science. 323 (5910): 101- ... and the NADP-dehydrogenases of the pentose-phosphate pathway. It has been demonstrated that peroxisomes generate superoxide (O2 ... the total activity of two enzymes in the pentose phosphate pathway, which is important for energy metabolism.[4] It is ...
Critical and non-critical forms[edit]. A critical race condition occurs when the order in which internal variables are changed ... "Canceling actions involves a race between basal ganglia pathways". Nature Neuroscience. 16 (8): 1118-24. doi:10.1038/nn.3456 ... Life-critical systems[edit]. Software flaws in life-critical systems can be disastrous. Race conditions were among the flaws in ... Critical race conditions cause invalid execution and software bugs. Critical race conditions often happen when the processes or ...
BDNF can promote protective pathways and inhibit damaging pathways in the NSCs and NPCs that contribute to the brain's ... BDNF is a critical mediator of vulnerability to stress, memory of fear/trauma, and stress-related disorders such as post- ... The activation of the BDNF-TrkB pathway is important in the development of short-term memory and the growth of neurons.[ ... BDNF mediates more pathways involved in these enrichment-induced processes than any other molecule and is strongly regulated by ...
Farley, Brian M.; Ryder, Sean P. (January 2008). "Regulation of Maternal mRNAs in Early Development". Critical Reviews in ... indicates that homeotic genes act to control development by selecting among alternative developmental pathways or programs. ... that is critical. Thus, a fly whose chromosomes are mutant in both copies of the Bicoid gene but who is born from a mother ...
Using Critical Pathways in Clinical Practice. Once completed, a critical pathway stipulates the preferred pattern of service ... A critical pathway can be viewed in CQI terminology as PDCA: Plan Do Check Act. The critical path is the Plan; the clinical ... A critical pathway can begin at any point in the health care delivery continuum. In developing a critical path for cranial base ... Other facilities assign critical pathway development to case managers, or hire outside consultants to develop the pathways. ...
Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] ...
Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ... requiring surgical intervention for critical limb ischemia (including amputation of the contralateral leg above the knee). ...
Care pathways are intended to improve outcomes by standardizing use of evidence-based practices, and a surgical pathway was ... However, this survey of obstetric care pathways for normal deliveries at Belgian hospitals found that the 17 pathways analyzed ... Necessity for a pathway for "high-alert" patients. Get Citation Shane R, Amer K, Noh L, Luong D, Simons S. Am J Health Syst ... Variation in 17 obstetric care pathways: potential danger for health professionals and patient safety? Get Citation Sarrechia M ...
critical pathway synonyms, critical pathway pronunciation, critical pathway translation, English dictionary definition of ... critical pathway. n. 1. A path. 2. Physiology a. A course usually followed by a body part or process. b. A chain of nerve ... Critical pathway - definition of critical pathway by The Free Dictionary https://www.thefreedictionary.com/critical+pathway ... pathway. (redirected from critical pathway). Also found in: Thesaurus, Medical, Legal, Encyclopedia.. Related to critical ...
... November 21, 2014. 0 ... Detection of such "cytosolic" DNA initiates a series of interactions that lead to the STING pathway. Activating the pathway ... "Our results demonstrate that a major mechanism for innate immune sensing of cancer occurs via the host STING pathway, with ... Understanding the role of the STING pathway provides insights into how we can wake up the immune response against tumors. ...
Thought you might appreciate this item(s) I saw at Critical Pathways in Cardiology.. ... Implementation of a Standardized Pathway for the Treatment of Cardiac Arrest Patients Using Therapeutic Hypothermia: "CODE ICE" ...
Schematic of the major fiber pathways through the basal ganglia (A); visualization of the fibers shows their dorsolateral ... Carnegie Mellon University BrainHub scientists have used a non-invasive brain-imaging tool to detect the pathways that connect ... Carnegie Mellon BrainHub Scientists Visualize Critical Part of Basal Ganglia Pathways (IMAGE) view more ... Carnegie Mellon BrainHub Scientists Visualize Critical Part of Basal Ganglia Pathways (image). Carnegie Mellon University ...
Although the discovery of a new genetic pathway in cells is important, much work remains to identify how the pathway influences ... "Oxidative stress control pathways for us humans are pretty important because we live in an environment where oxygen is required ... A key enzyme in the new pathway, dubbed Star-PAP by its Wisconsin discoverers, functions as part of a complex that controls the ... "Most of the genes this pathway controls are important for human disease," according to Richard A. Anderson of the UW School of ...
The Wnt signaling pathway plays a critical role in cell development, proliferation and differentiation. Mutations in this ... Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis. 26.11.2009 ... New Pathway Regulates Beta-Catenin Transactivation. The M. D. Anderson-led team made a surprising discovery: Beta-catenin also ... The newly described pathway disrupts the beta-catenin/alpha catenin complex through an EGFR-extracellular receptor kinase (ERK ...
Retrieved from "https://www.wikidoc.org/index.php?title=Abdominal_pain_duration_critical_pathways&oldid=1103216" ...
NIH study in mice uncovers pathway critical for UV-induced melanoma. Scientists have made an unanticipated discovery in mice ... "Our findings raise the possibility that targeting the interferon-gamma pathway may represent a novel, less toxic therapeutic ...
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ... Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways ...
Critical Pathways to Success in CNS Drug Development, 1st Edition. Neal R. Cutler, John J. Sramek, Michael F. Murphy, Henry ... Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS ...
A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia. Mei Li, Meiling Sun, Lijuan Cao, Jin-hua Gu, ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ... A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia ...
Critical pathways as a strategy for improving care: problems and potential. Ann Intern Med 1995;123:941-8. ... Use of a critical pathway for the management of community-acquired pneumonia: the CAPITAL study. Donald Farquhar ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ... Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of ...
... Nat Neurosci. 2005 Feb;8(2):212-9. doi: ... Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. ... incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway ...
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: ... signaling pathway. The observation that these pathways are targeted by several approved drugs used to treat the symptoms of RA ... In addition, many genes in RA loci are involved in the nuclear factor-kappaB signaling pathway or the Janus kinase (JAK)-signal ... cell-type specific gene expression or epigenetic marks have highlighted regulatory T cells and CD4 memory T cells as critical ...
Pathway awards in Neonatal Critical Care can lead to:. *Module only Professional Practice Level 6 ... For all course enquiries please contact the Neonatal Critical Care Pathway Leader, Sue Ward-Smith on:. *Tel: +44 (0)121 331 ... Year 2 Pathway Award (BSc (Hons) Only) - Exit Award: BSc (Hons) Professional Practice (Neonatal Critical Care) ... Once you have you have completed your Foundation Course in neonates, the Critical Care pathway will develop your career in ...
A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ... A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle ...
... the gaps in our knowledge about critical pathways are extensive; therefore, like any new health care technology, pathway ... Critical Pathways as a Strategy for Improving Care: Problems and Potential Steven D. Pearson, MD, MSc; Dorothy Goulart-Fisher, ... Critical Pathways as a Strategy for Improving Care: Problems and Potential. Ann Intern Med. 1995;123:941-948. doi: 10.7326/0003 ... A Critical Pathway for Management of Patients with Acute Chest Pain Who Are at Low Risk for Myocardial Ischemia: ...
Evaluation of a critical pathway for stroke The Journal of the American Osteopathic Association, May 1997, Vol. 97, 269. doi: ... Evaluation of a critical pathway for stroke You will receive an email whenever this article is corrected, updated, or cited in ... Evaluation of a critical pathway for stroke . J Am Osteopath Assoc 1997;97(5):269. doi: 10.7556/jaoa.1997.97.5.269. ... After the initiation of a critical pathway that begins its interventions in the Emergency Department, the length of stay ...
... is an inhibitor of the mTOR pathway, and work in various preparations has pointed to this pathway as being critical for ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ... Translational Control via the Mammalian Target of Rapamycin Pathway Is Critical for the Formation and Stability of Long-Term ...
A Critical Role for CHIP in the Aggresome Pathway. Youbao Sha, Lavannya Pandit, Shenyan Zeng, N. Tony Eissa ... A Critical Role for CHIP in the Aggresome Pathway Message Subject (Your Name) has forwarded a page to you from Molecular and ... In this study, we show that CHIP has a previously unexpected critical role in the aggresome pathway. CHIP interacts with iNOS ... This study reveals a critical role for CHIP in the aggresome pathway. ...
Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T. Repression of the Antioxidant NRF2 Pathway in Premature ... Reactivating the NRF2 pathway, by expressing constitutively active NRF2 (caNRF2) or treating cells with small-molecule NRF2 ... Finally, the scientists tested the effect of the NRF2 pathway on MSCs generated from HGPS patient fibroblasts. Loss of NRF2 in ... Impaired activity of the NRF2 antioxidant pathway is a driver mechanism in Hutchinson-Gilford progeria syndrome (HGPS). ...
Formation of Intracranial Tumors by Genetically Modified Human Astrocytes Defines Four Pathways Critical in the Development of ... Formation of Intracranial Tumors by Genetically Modified Human Astrocytes Defines Four Pathways Critical in the Development of ... Formation of Intracranial Tumors by Genetically Modified Human Astrocytes Defines Four Pathways Critical in the Development of ... Formation of Intracranial Tumors by Genetically Modified Human Astrocytes Defines Four Pathways Critical in the Development of ...
The Trehalose Pathway is critical for Aspergillus fumigatus virulence Srisombat Puttikamonkul*, Sven D. Willger, and Robert A. ... In this study, we have characterized the trehalose pathway in A. fumigatus for the first time. Phylogenetic analyses revealed ... Thus, as others have suggested, the trehalose pathway is worth exploiting as an antifungal drug target given its conservation ... lack of orlA did not affect the production of trehalose at 37 oC suggesting an alternate pathway for trehalose biosynthesis ...
Critical pathway in cell cycle may lead to cancer development. Salk researchers findings on chromosome shortening suggest a ... Critical pathway in cell cycle may lead to cancer development. Salk researchers findings on chromosome shortening suggest a ... Home - Salk News - Critical pathway in cell cycle may lead to cancer development ... When cells lose the function of p53, the gene at the center of the pathway, they can no longer arrest cells in the G1 phase, an ...
Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced ... Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced ... Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced ... Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced ...
Together, our results indicate that IL-1β but not members of the programmed death pathway is critical for human Th17 response ... Together, our results indicate that IL-1β but not members of the programmed death pathway is critical for human Th17 response ... However, the role of PD pathway in regulating Th17 response to M. tuberculosis has not been investigated. In the present report ... However, the role of PD pathway in regulating Th17 response to M. tuberculosis has not been investigated. In the present report ...
  • Most of the genes this pathway controls are important for human disease," according to Richard A. Anderson of the UW School of Medicine and Public Health and senior author of the new Nature report. (innovations-report.com)
  • A wealth of the genes involved in oxidative stress also seems to be the direct targets for the Star-PAP pathway. (innovations-report.com)
  • We've discovered a novel pathway that controls expression of genes important to oxidative stress," he says. (innovations-report.com)
  • In addition, many genes in RA loci are involved in the nuclear factor-kappaB signaling pathway or the Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling pathway. (nih.gov)
  • We constructed 4 gene pathway figures to explain the pathogenicity process that involves 24 key genes. (swpu.edu.cn)
  • This study implicates that contrast on the gene expression of the classifications in different infection stages provides critical information for the detection of tuberculosis, and our method can be utilized to narrow down the shortlist of disease relevant genes and explore tuberculosis pathogenesis. (swpu.edu.cn)
  • We applied Gene Ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis to explore biological pathways corresponding to the differentially expressed microRNAs (DEMs) associated with PA colonization. (globalresearchsyndicate.com)
  • The loss of Foxm1 inhibited expression of K-Ras target genes critical for the nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathways, including Ikbkb, Nfkb1, Nfkb2, Rela, Jnk1, N-Myc, Pttg1 and Cdkn2a . (nature.com)
  • FOXM1 is required for K-Ras-mediated lung tumorigenesis by activating genes critical for the NF-κB and JNK pathways. (nature.com)
  • Bottom line Coupling RNAi knockdown with microarray and RT-PCR analyses demonstrates to be always a versatile technique for determining genes governed by Wnt/-catenin pathway as well as for an improved understanding the function of the pathway in apoptosis. (neuroart2006.com)
  • It is well known that Wnt/-catenin pathway regulates the transcription of a suite of genes controlling numerous aspects of development and human diseases, ranging from cellular proliferation, differentiation and apoptosis [3,4]. (neuroart2006.com)
  • However, little is known about how Wnt/-catenin pathway regulates the expression of apoptosis-related genes. (neuroart2006.com)
  • Thought you might appreciate this item(s) I saw at Critical Pathways in Cardiology. (lww.com)
  • and Peter K. Vogt, PhD , of Scripps Research, La Jolla, California, for their contributions to understanding the role of the phosphoinositide 3-kinase (PI3K) and mechanistic target of rapamycin (mTOR) pathways in physiology and oncogenesis. (ascopost.com)
  • Cells use the mTORC1 (for "mechanistic target of rapamycin complex 1") pathway to regulate growth in response to the availability of certain nutrients, including amino acids. (mit.edu)
  • 4th November 2020 This document aims to open debate and discussion about alternative pathways to universal health coverage (UHC) beyond the proposals contained in. (polity.org.za)
  • Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. (innovations-report.com)
  • Although it is clear that proteasomal inhibition results in acceleration of the aggresome pathway, the molecular effectors involved in targeting proteins to aggresome sequestration are not well studied. (asm.org)
  • The Salk scientists identified the p53 pathway, a molecular mechanism that normally protects a cell's genetic material and suppresses tumors, as the key player in the response to telomere deprotection. (salk.edu)
  • Objective: In this study, the molecular mechanism by which EPO regulates the angiogenesis after cerebral ischemia through AMPK-KLF2 signaling pathway was investigated. (begellhouse.com)
  • Recent studies have provided evidence that the process of specific pathway formation may rely on a number of molecular guidance mechanisms and cues such as selective adhesion, growth cone avoidance, surface gradients, guidepost cells, and chemotropism. (begellhouse.com)
  • This review is an overview of the molecular structure, as it relates to function and mechanisms of action of some of the major gene families thought to be mediating specific axonal guidance and pathway formation. (begellhouse.com)
  • Researchers have uncovered a previously unknown molecular pathway that is critical to understanding cardiac arrhythmia and other heart muscle problems. (sciencedebate.com)
  • Molecular changes associated with age include telomere dysfunction, oxidative stress and deranged mitochondrial metabolism, inflammation, and cellular senescence, as well as altered signaling of sirtuins, insulin/insulin-like growth factor-1 (IGF-1), and the mammalian target of rapamycin (mTOR) pathway [ 3 , 4 , 5 ]. (mdpi.com)
  • In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest. (patentsencyclopedia.com)
  • Despite of the results, the molecular systems where Wnt/-catenin Ibudilast (KC-404) manufacture pathway regulates apoptosis are unclear as yet. (neuroart2006.com)
  • In spite of these findings, the molecular mechanisms by which Wnt/-catenin pathway exerts its effect on cellular apoptosis are not understood. (neuroart2006.com)
  • So when you lose this nutrient switch or if it can't be turned on, then the cell seems to freak out and cause all other growth promoting pathways to be turned on to somehow overcompensate for this loss. (mit.edu)
  • This inhibition is lost, however, when the EGFR pathway is activated. (innovations-report.com)
  • GSK3b inhibition is one my favorite pathways for enhancement. (selfhacked.com)
  • Inhibition of the activity of Wnt/-catenin pathway induces apoptosis in some cancer cell lines [24-36]. (neuroart2006.com)
  • Now, writing in the current edition (Feb. 21, 2008) of the journal Nature, a team of University of Wisconsin-Madison scientists reports the discovery of a gene expression pathway that exerts a sweeping influence over the process of oxidative stress. (innovations-report.com)
  • These findings represent the first demonstration that the NO/cGMP pathway exerts a feed-forward control on the corticostriatal synaptic plasticity. (elsevier.com)
  • The findings show that when activated, the STING pathway triggers a natural immune response against the tumor. (genengnews.com)
  • The research also found that targeted high-dose radiation therapy dials up the activation of this pathway, which promotes immune-mediated tumor control. (genengnews.com)
  • These findings could "enlarge the fraction of patients who respond to immunotherapy with prolonged control of the tumor," according to a commentary on the papers by the University of Verona's Vincenzo Bronte, M.D. "Enhancing the immunogenicity of their cancers might expand the lymphocyte repertoire that is then unleashed by interference with checkpoint blockade pathways," such as anti-PD-1. (genengnews.com)
  • In the tumor microenvironment in vivo, tumor cell DNA was detected within host antigen-presenting cells, which correlated with STING pathway activation and IFN-β production," wrote the investigators. (genengnews.com)
  • Taken together, these findings demonstrate the importance of this pathway in tumor formation and progression," Dr. Lu said, "and they reveal potential markers for prognosis and therapeutics. (innovations-report.com)
  • Although these studies demonstrated a critical role of FOXM1 in proliferation of neoplastic cells during lung tumor growth, the role of FOXM1 in tumor initiation is unknown. (nature.com)
  • In the current study, we gave infusions of RAP into the amygdala immediately after fear conditioning to determine whether disruption of the mTOR pathway in the amygdala affects fear memory formation. (jneurosci.org)
  • These experiments provide evidence that translational events controlled by the mTOR pathway contribute to long-term fear memory formation in the amygdala. (jneurosci.org)
  • The mTOR pathway may serve as a novel target to modulate the emergence of MDSCs in those pathophysiologic states in which these cells play an immunosuppressive role. (iupui.edu)
  • These orchestrated reactions, better described as metabolic pathways allow organisms to function and respond to environmental changes. (biotek.fr)
  • Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. (nih.gov)
  • demonstrated that the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway is involved in regulating the phosphorylation state of numerous factors implicated in controlling translation initiation, including eIF4E, 4E-BP1, and the ribosomal protein S6. (jneurosci.org)
  • To investigate functional outcomes after the application of a critical pathway for inpatient rehabilitation of total knee arthroplasty (TKA). (bvsalud.org)
  • In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type composition in a rat model of CIM using denervation and glucocorticoid administration (denervation and steroid-induced myopathy, DSIM). (elsevier.com)
  • All pathways in this second edition have been updated to reflect the latest findings regarding best practices in all areas of cardiovascular care. (ovid.com)
  • Our findings raise the possibility that targeting the interferon-gamma pathway may represent a novel, less toxic therapeutic alternative for effective treatment of malignant melanoma patients, who currently have poor cure rates. (nih.gov)
  • Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and chall. (nih.gov)
  • In this review, we discuss recent findings concerning the effects of aging on stem cells, contributions of stem cells to age-related pathologies, examples of signaling pathways at work in these processes, and lessons about cellular aging gleaned from the development and refinement of cellular reprogramming technologies. (mdpi.com)
  • As a doctoral candidate, Dr. Sabatini studied rapamycin and went on to discover the mTOR protein and signaling pathway. (ascopost.com)
  • Study of lal−/− bone marrow Ly6G+ MDSCs via transcriptional profiling showed increases in mammalian target of rapamycin (mTOR) signaling pathway transcripts. (iupui.edu)
  • A clinical care pathway was used by a multidisciplinary group of providers, which included acupuncturists, chiropractors, cognitive behavioral therapists, exercise therapists, massage therapists and primary care physicians. (chiro.org)
  • This clinical care pathway was a useful tool for the consistent application of evidence-based care for low back pain in the context of an integrative setting. (chiro.org)
  • For the first time, Carnegie Mellon University BrainHub scientists have used a non-invasive brain-imaging tool to detect the pathways that connect the parts of the basal ganglia. (eurekalert.org)
  • Certain diseases, like Parkinson's and Huntingdon's disease, are associated with damage to the pathways between the brain's basal ganglia regions. (vetscite.org)
  • Understanding the role of the STING pathway provides insights into how we can 'wake up' the immune response against tumors. (genengnews.com)
  • The Wnt signaling pathway plays a critical role in cell development, proliferation and differentiation. (innovations-report.com)
  • In this study, we show that CHIP has a previously unexpected critical role in the aggresome pathway. (asm.org)
  • However, the role of PD pathway in regulating Th17 response to M. tuberculosis has not been investigated. (frontiersin.org)
  • Cellular immunity plays a critical role in mediating the protection against tuberculosis. (frontiersin.org)
  • The PI3K pathway seems to play a pivotal role in B-CLL cell survival and growth. (nih.gov)
  • This pathway-which is regulated by nutrients and insulin-sensitive PI3K signaling-is the major regulator of growth and plays a central role in physiology, metabolism, aging, and the development of cancer. (ascopost.com)
  • Chapter 4 adds to the experimental evidence on the well studied residue Lys-362, for its critical role in transferring protons through the K-pathway. (illinois.edu)
  • Morante, J.R. "Crystallization pathways of multicomponent oxide nanocrystals: Critical role of the metal cations distribution in the case study of metal ferrites" Crystal Growth and Design 10, 12, pp. 5176 - 5181. (irec.cat)
  • These studies demonstrate that the systemic inflammatory response that affects MRL/fas lpr mice results in leukocyte rolling and adhesion in the cerebral microcirculation, and that the α 4 integrin/VCAM-1 pathway plays a central role in mediating these interactions. (monash.edu)
  • Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway. (semanticscholar.org)
  • The role of the IL-17 pathway in fungal sepsis remains controversial. (biomedcentral.com)
  • To address these discrepancies, we assessed the differential role of IL-17 pathway in two models of fungal sepsis: intravenous infection with live Candida albicans , in which fungal growth is the main cause of mortality, and zymosan-induced multiple organ failure in which the inflammatory pathology drives the mortality. (biomedcentral.com)
  • New developments in care planning will be reflected including critical pathways, and the role of models in Quality Assurance and Audit. (medicalbooks.co.nz)
  • Taken together, these data support a critical role for the ECE-1/ET-1 system in inflammation- associated premature delivery. (elsevier.com)
  • In this study, we investigated the role of the thalamic metabotropic glutamate receptor 1 (mGluR1)-phospholipase C β4 (PLCβ4) pathway in sleep control in PLCβ4-deficient (PLCβ4 -/- ) mice. (elsevier.com)
  • Taken together, these results reveal that RIPK1 has an important role in regulating the potent inflammatory pathways in authentic human macrophages that are poised to respond to external stimuli. (pasteur.fr)
  • Beutler, B 2003, ' Science review: Key inflammatory and stress pathways in critical illness - The central role of the Toll-like receptors ', Critical Care , vol. 7, no. 1, pp. 39-46. (elsevier.com)
  • Although significant improvement continues to be manufactured in understanding the downstream signaling cascade of RGS21 Wnt/-catenin pathway, the complete role of the pathway in apoptosis continues to be unclear. (neuroart2006.com)
  • demonstrated that Wnt/-catenin pathway plays a role in the progression of human prostate cancer, especially to the acquisition of apoptosis-resistant phenotype [42]. (neuroart2006.com)
  • LA JOLLA,CA-A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. (salk.edu)
  • Pathways controlling cell division/proliferation like the Hippo pathway are likely candidates for regulating parasite replication. (ipl.pt)
  • Agilent cell metabolism assays detect discrete changes in cell bioenergetics in real time, providing a window into the critical functions that provide ATP, the energy that cells need for activation, signaling, proliferation, and biosynthesis. (biotek.fr)
  • It's been demonstrated that pathway not merely is important in the advertising of cell proliferation and cell routine development, but also might provide a significant success function to facilitate cell change. (neuroart2006.com)
  • Our results demonstrate that a major mechanism for innate immune sensing of cancer occurs via the host STING pathway, with major implications for cancer immunotherapy. (genengnews.com)
  • Marrie T, Lau C, Wheeler S, Wong C, Vandervoort M, Feagan B. A controlled trial of a critical pathway for treatment of community-acquired pneumonia. (cmaj.ca)
  • Mutations in this important pathway leading to the activation of beta-catenin are responsible for many types of cancer, including colon cancer. (innovations-report.com)
  • The M. D. Anderson-led team made a surprising discovery: Beta-catenin also can travel to the nucleus via activation of the EGFR pathway-and it does so independently of Wnt signaling or mutations. (innovations-report.com)
  • Constitutive activity of the PI3K pathway in B-CLL cells when cultured with fibroblasts prevented the downregulation of the prosurvival Bcl-2 family protein Bcl-xL and the caspase inhibitor proteins FLIPL and XIAP, and consequently caspase-3 activation and apoptosis. (nih.gov)
  • Whitehead Institute scientists report that FLCN , the gene mutated in the rare hereditary disorder known as Birt-Hogg-Dubé cancer syndrome, is important for the activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway. (mit.edu)
  • In the case of Birt-Hogg-Dubé syndrome, the mutated gene prevents mTORC1 pathway activation early in the formation of tumors. (mit.edu)
  • Here we report that GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. (nature.com)
  • In the present study, we used transgenic mice expressing Kras G12D under control of Sftpc promoter to examine the kinetic of Foxm1 expression after activation of K-Ras/Raf/ERK signaling pathway in vivo . (nature.com)
  • In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death pathways. (pasteur.fr)
  • In contrast, TLR3/4 activation of WT macrophages-induced necroptosis only when caspases were inhibited, confirming the modulating effect of RIPK1 on RIPK3-mediated necroptosis through the FADD, Caspase-8 pathway. (pasteur.fr)
  • Activation of these inflammatory pathways required RIPK3 kinase activity while RIPK1 was dispensable. (pasteur.fr)
  • on the other hand, activation of the pathway inhibited chemotherapy-induced apoptosis [6]. (neuroart2006.com)
  • Meanwhile, activation of the Wnt/-catenin pathway inhibits Ibudilast (KC-404) manufacture Ibudilast (KC-404) manufacture apoptosis in some lines [37-41]. (neuroart2006.com)
  • The newly described pathway disrupts the beta-catenin/alpha catenin complex through an EGFR-extracellular receptor kinase (ERK)-protein kinase CK2- phosphorylation cascade. (innovations-report.com)
  • Both CtrA and CpdR are phosphorylated via the same CckA histidine kinase phospho-signaling pathway, providing a reinforcing mechanism that simultaneously activates CtrA and prevents its degradation by delocalizing the CpdR/ClpXP complex. (pnas.org)
  • Glycogen synthase kinase 3 (GSK-3 ) is an essential "brake" on many growth-signaling pathways including Wnt and insulin . (selfhacked.com)
  • Diverse assay formats and reagents have been developed that measure specific aspects of cell viability corresponding to particular cellular response pathways and mechanisms of injury. (biotek.fr)
  • Elucidating these mechanisms will more clearly reveal the potential of classical and non-classical pathways to mediate important effects of P4 and its metabolites, and potentially offer new therapeutic approaches to TBI. (frontiersin.org)
  • Background Wnt/-catenin pathway provides critical jobs in oncogenesis and advancement. (neuroart2006.com)
  • These data demonstrate that the IL-17 pathway does not have a major contribution to the inflammatory pathology leading to organ failure in fungal sepsis, and support the concept that the IL-17 pathway is protective during fungal sepsis. (biomedcentral.com)
  • These DEMs, whose expression levels correlated significantly with sputum inflammatory biomarkers (interleukin-1β and interleukin-8) level, were implicated in the modulation of the nuclear factor-κB, phosphatidylinositol and longevity regulation pathways. (globalresearchsyndicate.com)
  • The innate immune system is the first line of host defense, and its ability to propagate antimicrobial and inflammatory signals from the cellular microenvironment to the tissue at-large is critical for survival. (mit.edu)
  • Thus, the immunosuppressive milieu in tumors must be actively maintained, and tumors become susceptible to immune attack if the PTEN pathway in T reg s is disrupted. (umn.edu)
  • essential cell-apoptotic pathways, such as for example PTEN-PI3K-AKT pathway, NF-B pathway and p53 pathway, demonstrated significant alteration within their appearance level following the knockdown of -catenin. (neuroart2006.com)
  • This study illuminates a new pathway for therapeutic intervention,' says Paul Welling, M.D., professor of physiology at the University of Maryland School of Medicine. (sciencedebate.com)
  • Critical Pathways in Therapeutic Intervention. (wikipedia.org)
  • They found a new, previously unknown intracellular trafficking pathway that controls the number and location of the ion channels on the cell surface, affecting the passage of electrical charges and controlling the beat of the heart and other muscle activity. (sciencedebate.com)
  • The study in Cell describes a new intracellular trafficking pathway that controls the number and location of these ion channels on the cell surface. (sciencedebate.com)
  • Critical pathways are grounded in CQI methodology and use its scientific tools, such as teams, flowcharts, data collection, analysis of variance, and so. (asha.org)
  • Prevention pathways: application of the critical path methodology in occupational health services. (semanticscholar.org)
  • Critical pathways methodology - Habitat work schedule. (wa.gov)
  • It will be necessary to establish empirical support for critical pathway models and for the application of community practice guidelines. (freethesaurus.com)
  • The thalamic mGluR1-PLCβ4 pathway contains synapses that receive corticothalamic inputs. (elsevier.com)
  • Whitehead Member David Sabatini and other researchers have teased apart many components of this pathway, but the precise mechanism by which nutrient levels are actually sensed has remained elusive. (mit.edu)
  • Researchers say the pathway could be modulated with the help of transcranial magnetic stimulation or transcranial direct current stimulation. (sanedoublethink.com)
  • Researchers at the University of Pennsylvania School of Medicine have identified a link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein known to be expressed in a number of EBV-associated cancers. (news-medical.net)
  • The results of our study showed that thalamic mGluR1-PLCβ4 pathway was critical in controlling sleep architecture. (elsevier.com)
  • Activating the pathway triggers the production of interferon-beta, which in turn alerts the immune system to the threat, helps the system detect cancerous or infected cells, and ultimately sends activated T cells into the battle. (genengnews.com)
  • However, the Wisconsin group found that the newfound pathway contains a genetic "on-off" switch for a key protein known as heme oxygenase-1, an agent that protects cells from oxidative stress. (innovations-report.com)
  • The discovery of a gene expression pathway and specific enzymes that exert broad influence on the process of oxidative stress has clear clinical relevance, Anderson says, because it could potentially be manipulated to mitigate the damage oxygen does to cells. (innovations-report.com)
  • Oxidative stress control pathways for us humans are pretty important because we live in an environment where oxygen is required to keep us alive, but also stresses us because of oxidative damage to our cells," Anderson says. (innovations-report.com)
  • Although the discovery of a new genetic pathway in cells is important, much work remains to identify how the pathway influences human disease, Anderson says. (innovations-report.com)
  • Integration of GWAS results with cell-type specific gene expression or epigenetic marks have highlighted regulatory T cells and CD4 memory T cells as critical cell types in RA. (nih.gov)
  • Cells have a third pathway that involves sequestration of aggregated misfolded proteins, such as the mutant form of the cystic fibrosis transmembrane conductance regulator (CFTRΔF508), into specialized "holding stations" called aggresomes ( 14 ). (asm.org)
  • Reactivating the NRF2 pathway, by expressing constitutively active NRF2 (caNRF2) or treating cells with small-molecule NRF2 activators, including FDA-approved Oltipraz, rescued most HGPS cellular defects, as did treating HGPS cells with the general antioxidant N-acetyl cysteine. (cancer.gov)
  • The pathway controlling G1-phase growth arrest, however, is commonly altered in cancer cells, allowing cancer cells to divide despite shortened telomeres, which can lead to the genomic instability seen in malignant cells. (salk.edu)
  • When cells lose the function of p53, the gene at the center of the pathway, they can no longer arrest cells in the G1 phase, an important point in the cell cycle for repairing DNA damage or, if the damage cannot be repaired, targeting the cell for programmed death. (salk.edu)
  • Because telomere deprotection results in a partial DNA damage response that only arrests cells in G1 through the p53 pathway, once cells lose p53 function telomere deprotection no longer arrests growth. (salk.edu)
  • Indeed, IFN-γ-producing CD4 + T helper type 1 cells are critical for the control of M. tuberculosis in humans and murine models ( 1 - 4 ). (frontiersin.org)
  • FLCN 's dual roles-as a cause of a rare cancer in its mutated form and as a trigger for a growth pathway that is often hijacked in cancer cells-has prompted Tsun and Sabatini to rethink how a mutation can push cells to become cancerous. (mit.edu)
  • Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. (mdpi.com)
  • We highlight emerging therapeutic approaches to manipulation of key signaling pathways corrupting or exhausting adult stem cells, as well as other approaches targeted at maintaining robust stem cell pools to extend not only lifespan but healthspan. (mdpi.com)
  • Understanding the cellular processes responsible for the triage of misfolded proteins is critical for elucidating the pathophysiology of many diseases associated with misfolded proteins. (asm.org)
  • Hence, Wnt/-catenin pathway may be connected with cellular apoptosis. (neuroart2006.com)
  • Many hospitals in Canada and the United States have implemented critical pathways (CPs) to reduce variation and control costs in the management of several common conditions. (cmaj.ca)
  • Steps were taken to ensure that treating personnel at the hospitals allocated to conventional management had no knowledge of any of the constituent parts of the critical pathway. (cmaj.ca)
  • Despite the rapid dissemination of critical pathway programs in hospitals throughout the United States, many uncertainties remain about their development, implementation, and evaluation.In addition, serious concerns have been raised about their effect on patient outcomes and satisfaction with care, physician autonomy, malpractice risks, and the teaching and research missions of many hospitals. (annals.org)
  • Reflects new developments including patient-focussed hospitals and critical pathways. (medicalbooks.co.nz)
  • Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues. (nih.gov)
  • The amygdala is thought to be the brain area where critical synaptic plasticity occurs, supporting the formation of fear memory ( Fanselow and LeDoux, 1999 ). (jneurosci.org)
  • Chapter 2 describes the characteristics of mutations at the residue Met-107 near the critical proton transferring residue in the D-pathway, Glu-286. (illinois.edu)
  • Critical pathway development: an integrative literature review. (semanticscholar.org)
  • This paper describes the use of a care pathway designed to guide treatment by an integrative group of providers within a randomized controlled trial. (isharonline.org)
  • Here we utilized a meta-dimensional integrative approach to seek genetically susceptible pathways that may be associated with tumorigenesis and progression of EC. (cdc.gov)
  • 1993). Critical paths are a framework for coordinating team work, a route to streamlining health care delivery. (asha.org)
  • Coverage includes new pathways for pre-hospital care, public access defibrillation for cardiac arrest, emergency department management of heart failure and atrial fibrillation, aortic aneurysm, hyperglycemia, peripheral artery disease and claudication, implantable cardioverter defibrillator treatment for ventricular tachycardia, and long-term management of diabetes and the metabolic syndrome. (ovid.com)
  • These pathways combine evidence-based practice parameters with guidelines for the timely completion of specific steps in the process of care. (cmaj.ca)
  • Critical pathways as a strategy for improving care: problems and potential. (cmaj.ca)
  • Once you have you have completed your Foundation Course in neonates, the Critical Care pathway will develop your career in neonatal nursing with confidence and skill. (bcu.ac.uk)
  • In an era of increasing competition in medical care, critical pathway guidelines have emerged as one of the most popular new initiatives intended to reduce costs while maintaining or even improving the quality of care.Developed primarily for high-volume hospital diagnoses, critical pathways display goals for patients and provide the corresponding ideal sequence and timing of staff actions for achieving those goals with optimal efficiency. (annals.org)
  • Physicians should understand the potential benefits and problems associated with critical pathways because physicians are increasingly being asked to provide leadership for pathway programs.Physicians and other health service investigators should also develop methods to study pathways in evolving health care settings. (annals.org)
  • therefore, like any new health care technology, pathway programs should be fully evaluated in order to understand the conditions under which that promise may be fulfilled. (annals.org)
  • The essential tool of managed care systems is a critical pathway, which is developed through the collaboration of health care team members. (semanticscholar.org)
  • Critical care is now used as a term that encompasses intensive care or intensive therapy provided in intensive care units (ICUs) or intensive therapy units (ITUs), together with what used to be called high-dependency care provided in high-dependency units (HDUs). (nice.org.uk)
  • Recently the distinctions have become blurred, hence the increasing use of the term critical care. (nice.org.uk)
  • Approximately 110,000 people spend time in critical care units in England and Wales each year, the majority surviving to be discharged home. (nice.org.uk)
  • For many, discharge from critical care is the start of an uncertain journey to recovery characterised by, among other problems, weakness, loss of energy and physical difficulties, anxiety, depression, post-traumatic stress (PTS) phenomena and, for some, a loss of mental faculty (termed cognitive function). (nice.org.uk)
  • AIM: Preliminary assessment of the effectiveness of the Liverpool Care Pathway on the quality of end-of-life care provided to adult cancer patients during their last week of life in hospital. (isharonline.org)
  • SETTINGS/PARTICIPANTS: The trial was performed within four hospital wards participating in the pilot implementation of the Italian version of the Liverpool Care Pathway programme. (isharonline.org)
  • Care pathways have been developed with the aim of ensuring that dying patients and their family members received by health professionals the most appropriate care. (isharonline.org)
  • This review presents and discusses the evidence supporting the effectiveness of the end-of-life care pathways. (isharonline.org)
  • Models and Critical Pathways in Adult Hospital-Based Care. (medicalbooks.co.nz)
  • The book will remain practical and critical in style, encouraging a creative response to the use of models in nursing care. (medicalbooks.co.nz)
  • I have been unable to find more recent figures.Our goal is to train future leaders in academic pulmonary and critical care medicine. (kaleiseminari.com)
  • Since then, critical pathways -- also called Critical Pathway Care Maps, Action Plans, Multidisciplinary Action Plans, or Clinical Pathways -- have been adapted to meet the needs of different health care organizations that are implementing so-called case management models, the basis of subacute care programs that are evolving today. (freethesaurus.com)
  • This paper describes a set of critical pathways (CPs) designed to provide uniform criteria for clinical decision-making at different levels of care of pregnant patients with preeclampsia or severe preeclampsia. (springer.com)
  • Critical Care , 7 (1), 39-46. (elsevier.com)
  • Clinical pathways have been defined as structured, multidisciplinary plans of care designed to support the implementation of protocols and clinical management. (chiro.org)
  • I am an emergency and critical care physician. (kevinmd.com)
  • I am a critical care and emergency medicine physician, I have had COVID-19 infection twice, and I'm tired. (kevinmd.com)
  • Do protocols and pathways improve care? (kevinmd.com)
  • Hence, a balanced exposure to UV radiation is critical, and is maintained by the regulation of melanin synthesis. (biomedcentral.com)
  • By offering the course at level six and level seven, we can also aid with your academic progression, as you feel is appropriate for your planned career pathway. (bcu.ac.uk)
  • The three scientists honored with the 2019 Louis Gross Horwitz Prize played key roles in identifying and deciphering the PI3K pathway. (ascopost.com)
  • Dr. Cantley's laboratory discovered the PI3K signaling pathway in the mid-1980s. (ascopost.com)
  • The major symptoms of these diseases include rising breathlessness, frequent chest infections, and constant cough with phlegm "Introduction," Jining Lu microRNAs as critical posttranscriptional regulators in airway epithelial or lung mesenchymal cell differentiation in response to injury Dr. (kaleiseminari.com)
  • Chen … Debate Wnt/-catenin pathway is certainly involved in several differentiation occasions during embryonic advancement and network marketing leads to a variety of diseases, most cancer notably, when activated [3-5] aberrantly. (neuroart2006.com)
  • Study identifies a neural pathway associated with error monitoring and attention function in some psychiatric disorders such as ADHD, ASD, and schizophrenia. (sanedoublethink.com)
  • TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. (jneurosci.org)
  • Consistent with CQI philosophy, pathway development teams must have input from all process stakeholders, so they typically include representatives of the patient population and a variety of caregivers. (asha.org)
  • We measured the overall consistent rankings of these pathways in all four data types. (cdc.gov)
  • We analyzed GWAS data obtained from Connecticut Endometrial Cancer Study (CECS) and identified the top 20 EC susceptible pathways. (cdc.gov)
  • To further verify the significance of top 20 EC susceptible pathways, we conducted pathway-level multi-omics analyses using EC exome-Seq, RNA-Seq and survival data, all based on The Cancer Genome Atlas (TCGA) samples. (cdc.gov)
  • Thus, as others have suggested, the trehalose pathway is worth exploiting as an antifungal drug target given its conservation in other pathogenic fungi and absence in humans. (aspergillus.org.uk)
  • Research on the longer-term consequences of critical illness has shown that significant numbers of patients surviving critical illness have important continuing problems. (nice.org.uk)
  • Patients who underwent critical pathway rehabilitation after TKA showed significant improvements in functional measurements during the first 3 months post-surgery. (bvsalud.org)
  • Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. (elsevier.com)
  • A key enzyme in the new pathway, dubbed Star-PAP by its Wisconsin discoverers, functions as part of a complex that controls the expression of messenger RNA, all-important molecules that carry genetic information from the nucleus of a cell to the cytoplasm where proteins are made. (innovations-report.com)
  • Zinc is a co-factor for at least 70 critical enzyme pathways. (nutramed.com)
  • In this study, we have characterized the trehalose pathway in A. fumigatus for the first time. (aspergillus.org.uk)
  • In this study, we demonstrate a new technique for assessing and reconstructing human-mediated pathways of alien forest species entries to major settlements in Canada via commercial road transportation and domestic trade. (gc.ca)
  • In the present study, we investigated the effect of ghrelin on podocyte survival as well as the signalling pathways mediating ghrelin effect in immortalized cultured rat podocytes. (edu.lb)
  • Existing treatments for lung cancers have not significantly improved patient survival, leading to a critical need for new therapeutic approaches. (nature.com)
  • This is an unexpected finding, as some cancers keep this pathway turned on to fuel their unchecked growth and expansion. (mit.edu)
  • A key component of the Wnt pathway, beta-catenin combines with alpha-catenin and regulates cell-cell adhesion. (innovations-report.com)
  • Exploring critical uncertainties in pathway assessment of human assisted introductions of alien forest species in Canada. (gc.ca)
  • 3 Key components of the pathway included a risk-stratification tool (pneumonia severity index) to guide decision-making about hospital admission, a recommendation to use a single, broad- spectrum antimicrobial agent (levofloxacin, 500 mg once daily) and guidelines for the timing of conversion from intravenous to oral antibiotic therapy and hospital discharge. (cmaj.ca)
  • Here, we report the identification of a protein, CpdR, that directs ClpXP localization to the cell pole and show that CpdR function is under the control of a phospho-signaling pathway, thus establishing a mechanism for providing temporal and spatial specificity to bacterial proteases. (pnas.org)
  • Some well-studied pathways, such as p53 signaling and cell cycle pathways, show consistently high rankings across different analyses. (cdc.gov)
  • Additionally, other cell signaling pathways (e.g. (cdc.gov)
  • In summary, P4 has the potential to become the first clinically effective treatment for TBI, and the effects of P4 and its metabolite ALLO in TBI may involve Pgr, mPRs, and other signaling pathways. (frontiersin.org)
  • Rapid clearance of the master regulator, CtrA, by the ClpXP protease is a critical event that enables the initiation of chromosome replication at specific times in the cell cycle. (pnas.org)
  • The regulation of cell cycle pathways requires the precise timing of both production and degradation of regulatory proteins. (pnas.org)
  • Additionally, the immune system is a critical consideration for vaccine development and cell, tissue and organ transplants. (biotek.fr)
  • History The Wnt/-catenin pathway provides key jobs in embryonic patterning and cell-fate perseverance [1,2]. (neuroart2006.com)
  • IGF-1/mTOR, rac-1 and IL-5 pathway), genetic information processing pathway (e.g. homologous recombination) and metabolism pathway (e.g. sphingolipid metabolism) are also highly associated with EC risks, diagnosis and prognosis. (cdc.gov)
  • Capitated health plans are embracing critical pathways as a superior way to manage costs and ensure high-quality outcomes for inpatients and outpatients alike. (freethesaurus.com)