Schedules of medical and nursing procedures, including diagnostic tests, medications, and consultations designed to effect an efficient, coordinated program of treatment. (From Mosby's Medical, Nursing & Allied Health Dictionary, 4th ed)
The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).
An organized procedure carried out through committees to review admissions, duration of stay, professional services furnished, and to evaluate the medical necessity of those services and promote their most efficient use.
The capacity of an organization, institution, or business to produce desired results with a minimum expenditure of energy, time, money, personnel, materiel, etc.
The period of confinement of a patient to a hospital or other health facility.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Experience with a managed care approach to HIV infection: effectiveness of an interdisciplinary team. (1/353)

To evaluate the function and effectiveness of a multidisciplinary team for managing human immunodeficiency virus (HIV) infection, we conducted a follow-up cohort study of HIV-positive patients managed according to a clinical care path at a staff-based health maintenance organization (HMO). The study group consisted of 230 HIV-positive health plan members who received care at the Kaiser Permanente Santa Rosa medical center (KPMC-SRO). In 1994, the comparison group consisted of 4747 HIV-positive health plan members who received care at Kaiser Permanente's 18 other medical centers in northern California. The percentages of acquired immunodeficiency syndrome (AIDS) and HIV-positive patients as determined by CD4+ T-cell counts were similar (P = 0.97). Compared with patients at the other Kaiser Permanente medical centers, KPMC-SRO patients had more visits with nurse practitioners (rate ratio [RR] = 1.72) and nutritionists (RR = 12.3) and fewer visits with primary care physicians (RR = 0.82). More HIV-positive members at KPMC-SRO received social workers' services (27% at KPMC-SRO vs 6% for patients at the other Kaiser Permanente medical centers) and fewer used emergency services (RR = 0.92) and psychiatric services (RR = .89). At KPMC-SRO, the mean number of days that AIDS patients spent in the hospital decreased from 7.8 (1991) to 2.01 (1994). Hospital admissions were fewer (AIDS patients, RR = 0.67; HIV-positive patients without AIDS, RR = 0.45), and length of stay was briefer, compared with patients at the other Kaiser Permanente Medical Centers. The mean cost of HIV-related drugs for patients seen at KPMC-SRO ($2343 per infected member) was lower than that for patients seen elsewhere in the region ($3289 per infected member). These results suggest that in an HMO setting, managed care provided by a dedicated interdisciplinary team according to a clinical care path can substantially and favorably affect resource use.  (+info)

The development and implementation of normal vaginal delivery clinical pathways in a large multihospital health system. (2/353)

The entire country has become more concerned with healthcare costs due to managed care, capitation risk-based contracts, and the near elimination of the cost-plus reimbursement system. Clinical pathways have become one way to reduce unnecessary resource consumption by reducing provider variance, improving clinical outcomes, and reducing cost. We present here our rationale and process for developing a common clinical pathway for normal vaginal delivery in a large and varied multihospital system. We also discuss how this new pathway is expected to improve quality of care and reduce costs.  (+info)

Influence of a critical path management tool in the treatment of acute myocardial infarction. Clinical Quality Improvement Network Investigators. (3/353)

OBJECTIVE: The primary objective of this study was to determine the effect of implementing a critical path on use of proven efficacious therapies and outcomes in patients admitted to a hospital with acute myocardial infarction (AMI). The secondary objectives were to evaluate the use of unproven medications and to develop an understanding of the factors associated with adverse in-hospital outcomes in these patients. STUDY DESIGN: A nonrandomized before-after study design was used to evaluate the efficacy of a critical path instrument in patients admitted to hospital with AMI. PATIENTS AND METHODS: Consecutive patients admitted with AMI in nine participating hospitals were enrolled in the study. The critical path instrument consisted of a locally developed, preprinted physician order form. Practice patterns were determined before (n = 2305) and after (n = 2349) implementation of the critical path by primary chart review. Multivariate analysis of risk factors for mortality was performed on a combined database of 6088 AMI patients. RESULTS: The use of acetylsalicylic acid (ASA), nitrates, and beta blockers increased significantly by 3%, 2%, and 9%, respectively, after implementation of the critical path. Use of thrombolytics remained stable at 41%, and calcium channel blocker use decreased significantly by 8%. In-hospital mortality decreased by 1%. There was less use of ASA, nitrates, beta blockers, and thrombolytic therapy in women and the elderly. Multivariate analysis showed that advanced age was associated with increased mortality risk, whereas ASA, beta blockers, nitrates, and calcium channel blockers were associated with reduced mortality risk. CONCLUSION: Implementation of a critical path resulted in increased use of proven efficacious therapies, reduced use of noneffective therapy, and a trend toward reduced mortality.  (+info)

Evaluating and improving the delivery of heart care: the University of Michigan experience. (4/353)

With increasing pressure to curb escalating costs in medical care, there is particular emphasis on the delivery of cardiovascular services, which account for a substantial portion of the current healthcare dollar spent in the United States. A variety of tools were used to improve performance at the University of Michigan Health System, one of the oldest university-affiliated hospitals in the United States. The tools included initiatives to understand outcomes after coronary bypass operations and coronary angioplasty through use of proper risk-adjusted models. Critical pathways and guidelines were implemented to streamline care and improve quality in interventional cardiology, management of myocardial infarction, and preoperative assessment of patients undergoing vascular operations. Strategies to curb unnecessary costs included competitive bidding of vendors for expensive cardiac commodities, pharmacy cost reductions, and changes in nursing staff. Methods were instituted to improve guest services and partnerships with the community in disease prevention and health promotion.  (+info)

Infrarenal aortic surgery with a 3-day hospital stay: A report on success with a clinical pathway. (5/353)

PURPOSE: This paper reports on an experience with a clinical pathway for elective infrarenal aortic surgery (AS) that targeted hospital discharge on postoperative day (POD) 3. The pathway incorporated early feeding, early ambulation, and selective use of the intensive care unit (ICU). METHODS: A review of 50 consecutive hospital discharges after AS (aneurysm repair and aortofemoral bypass grafting) by a single surgeon performed from April 1996 through June 1998 with this clinical pathway is reported. The data collected included morbidity rate, mortality rate, length of stay (LOS), and number of hospital readmissions. RESULTS: The average LOS for all patients was 3.0 days. Only six patients (12%) were admitted to the ICU. Discharge on POD 3 was achieved in 80% of the group (40 of 50), and increasing experience improved compliance, with 92% of the most recent 25 patients (23 of 25) being discharged by POD 3. Eleven of these 25 patients (44%) were discharged on POD 2. No patient was readmitted to the hospital within a 30-day period after discharge. There was no mortality after AS during this period. CONCLUSION: Factors that limit the discharge of patients recovering from AS include the ability to ambulate independently and to tolerate a diet. Ambulation and feeding on POD 1 were well tolerated by most patients, which shortened the period of hospitalization. Admission to the ICU was infrequently required when a monitored surgical step-down unit was available. Discharge by POD 3 for AS has been proven to be routinely achievable, safe, and well accepted by patients and to reduce the cost of hospitalization.  (+info)

The role of clinical practice guidelines in disease management. (6/353)

This activity is designed for medical directors, pharmacy directors, quality assurance managers, and all members of disease management or quality improvement teams. GOAL: To review the guideline literature and help healthcare organizations plan guideline development and implementation strategies. OBJECTIVES: 1. Clarify the terminology used in practice policy development. 2. Explain how guideline implementation is related to disease management. 3. Discuss interventions utilized to enhance guideline adoption. 4. Provide a stepwise plan for healthcare organizations to follow.  (+info)

New picture archiving and communications system plus new facility equals critical path planning challenge. (7/353)

The architectural design and construction of a new imaging department is one of the most complex challenges in healthcare architecture. When a client also plans a simultaneous change in basic operating system technology from film-based to filmless imaging, the challenge for both hospital management and the facility/technology design team is even more complicated. A purposeful planning process plus a carefully composed team of internal and external experts are the two essentials for success in executing this difficult conversion of both facility and technology.  (+info)

A community hospital-based congestive heart failure program: impact on length of stay, admission and readmission rates, and cost. (8/353)

OBJECTIVE: To do an analysis of patients with a primary diagnosis of congestive heart failure at discharge before (n = 407) and after (n = 347) the implementation of a comprehensive inpatient and outpatient congestive heart failure program consistent with the guidelines of the Agency for Health Care Policy and Research. STUDY DESIGN: A retrospective analysis of the impact of the congestive heart failure program on length of stay, admission and readmission rates, and costs to both patient and provider. The program, which used a multidisciplinary team approach, included an intensive education program focusing on diet, compliance, and symptom recognition, as well as the use of outpatient infusions. It also incorporated aggressive pharmacologic treatment for patients with advanced congestive heart failure. RESULTS: Our analysis revealed significant decreases in length of stay, admission and readmission rates, and costs to the patient and provider (P < or = .05). The mean cost per admission decreased 17% ($1118), and a substantial 77% ($718,468) net reduction in nonreimbursed (lost) hospital revenue was noted. CONCLUSION: A multidisciplinary, comprehensive congestive heart failure program can improve patient care in a community-hospital setting while significantly reducing costs to both the patient and the institution.  (+info)

1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.

It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.

This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses. The innate immune system ... The cGAS-STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, ... The cGAS/STING pathway also has a role in tumor surveillance. In response to cellular stress, such as DNA damage, cells will ... The cGAS - STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP- ...
Critical Pathways in Cardiology. 18 (4): 167-175. doi:10.1097/HPC.0000000000000189. PMID 31725507. S2CID 208036312. "A Doctor's ... "An Updated Healthcare System-Wide Clinical Pathway for Managing Patients With Chest Pain and Acute Coronary Syndromes". ...
Critical Pathways in Cardiology. 10 (10): 44-45. doi:10.1097/HPC.0b013e31820b887b. PMID 21562375. "UOTW #14 - Ultrasound of the ...
Critical Pathways in Cardiology. 20 (3): 155-162. doi:10.1097/HPC.0000000000000256. ISSN 1535-2811. PMID 33606411. S2CID ... The training and career pathways for internists vary considerably across the world. Many programs require previous ... Internists may work in many settings including outpatient clinics, inpatient wards, critical care units, and emergency ... Cardiovascular disease, dealing with disorders of the heart and blood vessels* Clinical cardiac electrophysiology Critical care ...
Critical Pathways in Cardiology. 5 (4): 187-90. doi:10.1097/01.hpc.0000249784.29151.54. PMID 18340236. Pearson, T. A. (2007). " ...
Critical Pathways in Therapeutic Intervention. Missouri: Mosby Inc. p. 262. ISBN 0-323-00105-X. "Nerve Injury (Neuropraxia, ...
The Notch signaling pathway was found to be critical mainly for neural progenitor cell (NPC) maintenance and self-renewal. In ... The Notch signaling pathway is a critical component of cardiovascular formation and morphogenesis in both development and ... The Notch pathway is essential for maintaining NPCs in the developing brain. Activation of the pathway is sufficient to ... Notably, this system allows multiple synthetic pathways to be engineered into a cell in parallel. The Notch signaling pathway ...
Cannon C, O'Gara P (2007). Critical Pathways in Cardiovascular Medicine (2nd ed.). Lippincott Williams & Wilkins. p. 243. ISBN ... There are other pathways involving obesity, triglyceride levels, insulin sensitivity, endothelial function, and thrombogenicity ... 2017). "Dietary fat and breast cancer mortality: A systematic review and meta-analysis". Critical Reviews in Food Science and ...
"The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection". ... The lectin pathway or lectin complement pathway is a type of cascade reaction in the complement system, similar in structure to ... The lectin pathway starts with mannose-binding lectin (MBL) or ficolin binding to certain sugars. In this pathway, mannose- ... Classical complement pathway Alternative complement pathway Mannan-binding lectin Wallis R, Mitchell DA, Schmid R, Schwaeble WJ ...
Use and evaluation of critical pathways in hospitals. Eff Clin Pract 2002; 5:114-119. De Luc K., Developing care pathways - the ... International survey on the use and dissemination of clinical pathways in 23 countries, Journal of Integrated Care Pathways, ... The European Pathway Association (E-P-A.org) is a European non-profit organisation which brings together researchers, managers ... European Pathway Association (Articles with short description, Short description is different from Wikidata, AC with 0 elements ...
Pathways Listening, Speaking, and Critical Thinking by MacIntyre. Douglas, Scott R. Academic Inquiry: Writing for Post- ... Robert Lowth (26 March 1794). A Short Introduction to English Grammar: With Critical Notes. Printed for J.J . Tourneisin - via ...
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The second pathway, is called the direct (or Go) pathway and is excitatory. This pathway inhibits the GPi, resulting in the ... Two pathways emerge from the striatum. One pathway is called the indirect (or NoGo) pathway and is inhibitory. This projects to ... As of 2013 there was intense debate with regards to division of the circuit, pathway interactions, number of pathways and ...
"Direct and indirect pathways of basal ganglia: a critical reappraisal". Nature Neuroscience. 17 (8): 1022-1030. doi:10.1038/nn. ... The motor and oculomotor pathways are sometimes grouped into one motor pathway.) The five general pathways are organized as ... The short indirect pathway has been proposed to, in a direct push pull antagonism with the direct pathway, close the gate to ... However the speed of the direct pathway would not be concordant with the indirect pathway in this model leading to problems ...
The indirect pathway also receives excitatory input from various brain regions. Indirect pathway medium spiny neurons project ... Dopamine plays critical roles in the regulation of psychomotor functions in the brain (Bromberg-Martin et al., 2010; Cools, ... However, direct pathway medium spiny neurons mostly signal sequence initiation/termination and indirect pathway medium spiny ... D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. Most striatal MSNs contain only D1-type or D2-type ...
Juliet J. Fall: Reading Claude Raffestin: pathways for a critical biography. In: Environment and Planning D: Society and Space ...
Smith appears on the albums Critical Mass (2005) and Pathways (2009). In 2017, he released his first album as leader, Kinfolk: ... 1 (ArtistShare, 2014) More Than Meets the Ear (ArtistShare, 2015) With Dave Holland Critical Mass (Dare2, 2006) Pathways (Dare2 ...
Hence binding site on protein are critical parts of signal transduction pathways. Types of ligands include neurotransmitters, ... Its regulation in glycolysis is imperative because it is the committing and rate limiting step of the pathway. PFK also ... This regulation efficiently conserves glucose reserves, which may be needed for other pathways. Citrate, an intermediate of the ... Binding sites incur functional changes in a number of contexts, including enzyme catalysis, molecular pathway signaling, ...
Chung, DC (2000). "The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis". Gastroenterology ... Both the β-catenin gene and the APC gene are involved in the same cell growth signalling pathway, but the APC gene is known to ...
The Hippo pathway also has a critical role in stem cell and tissue specific progenitor cell self-renewal and expansion. The ... The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ ... The pathway takes its name from one of its key signaling components-the protein kinase Hippo (Hpo). Mutations in this gene lead ... The Hippo pathway consists of a core kinase cascade in which Hpo phosphorylates (Drosophila) the protein kinase Warts (Wts). ...
Cilia defects adversely affect numerous critical developmental signaling pathways essential to cellular development. Other ...
A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066X.58.1.53 ... A critical review of the evidence for biological pathways". American Psychologist. 58 (1): 53-63. doi:10.1037/0003-066x.58.1.53 ...
"A critical role for the mTORC2 pathway in lung fibrosis". PLOS ONE. 9 (8): e106155. Bibcode:2014PLoSO...9j6155C. doi:10.1371/ ... The mTORC2 pathways plays a crucial role in pathogenesis of lung fibrosis, and inhibitors of its active site such as ... Studies using mice with tissue-specific loss of Rictor, and thus inactive mTORC2, have found that mTORC2 plays a critical role ... Mendoza MC, Er EE, Blenis J (June 2011). "The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation". Trends in ...
... a critical enzyme in the cholesterol biosynthesis pathway". Clin. Genet. 75 (1): 19-29. doi:10.1111/j.1399-0004.2008.01099.x. ... The core biosynthetic route is via a polyketide synthase pathway from 10 acetates, 4 methyls of methionines, 1 succinate, and 1 ...
A number of critical developmental signaling pathways essential to cellular development have been discovered. These are ... Signal transduction pathways involved include the Hedgehog signaling pathway and the Wnt signaling pathway. Dysfunctional cilia ... Cilia may thus be "viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes ... cilia are critical for: development homeostasis reproduction "Just as different genes can contribute to similar diseases, so ...
The cilia defects adversely affect "numerous critical developmental signaling pathways" essential to cellular development. The ...
A critical role of p38/nuclear factor-kappa B signaling pathway". The Journal of Biological Chemistry. 278 (8): 5750-5759. doi: ...
Mundinano, Inaki (2018). "Transient visual pathway critical for normal development of primate grasping behavior". Proceedings ... Berman, R. A.; Wurtz, R. H. (12 January 2011). "Signals Conveyed in the Pulvinar Pathway from Superior Colliculus to Cortical ... "The Visual Pathway from Below" (All articles with unsourced statements, Articles with unsourced statements from October 2018, ... "Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus". Nature Communications. ...
A Critical Review of Nitrogenous Disinfection Byproduct Formation Pathways". Environmental Science & Technology. 46 (1): 119- ...
This meant that it affected the activation of both pathways and plays a critical role. The other two amino acids which were ... Y1493.50 still activated both PKC and ERK1/2 suggesting that they did not play a critical role in the activation of the pathway ... The receptor cannot activate the PKC but it can still activate the ERK1/2 pathway although it is a little bit slower. There ... The mutated D972.50 receptor could not activate PKC nor could it activate the ERK1/2 pathway. ...
Ajiro M, Nishidate T, Katagiri T, Nakamura Y (November 2010). "Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary ... inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway". Bosn J Basic Med Sci. 19 (1): 52- ... in the Akt pathway in breast cancer cells". Int. J. Oncol. 35 (4): 673-81. PMID 19724902. ...
In Critical Cyberculture Studies edited by D. Silver and A. Massanari. New York: NYU Press. pp.107-118. Raine, L. & Wellman, B ... Wasáse: Indigenous pathways of action and freedom. Toronto: University of Toronto Press. Kwet, M. 2019 "Digital Colonialism: US ... This critical insight has been applied in fields like copyright, free speech regulation, Internet governance, blockchain, ... "Is the Post- in Postmodernism the Post- in Postcolonial?" Critical Inquiry, vol 17. pp. 336-357; Shohat, E. 1992. "Notes on the ...
However, this pathway to change is vulnerable to the loss of the key individual leader." Pransky has reviewed the research on ... This method of reaching "critical mass" of HR awareness within these organizations appears to be both efficient and effective ... showing that negative and stressful feelings are self-generated and thus can be self-quieted and it seeks to provide a pathway ...
These same pathways are available for exploitation by a terrorist organization or any nation or person wishing to attack us ... Rudolph Giuliani claimed that border security is one of the most critical issues facing the United States today and should by ... These same pathways are available for exploitation by a terrorist organization or any nation or person wishing to attack us ...
The emission pathways that reach 1.5 °C contained in the report assume the use of carbon dioxide removal (CDR) to offset for ... Shaw, James (2018-10-08). "International global warming report lays out the critical challenge". The official website of the ... Pathways that overshoot the goal rely on CDR to remove carbon dioxide at a rate that exceeds remaining emissions in order to ... Pathways limiting global warming to 1.5 °C with no or limited overshoot would require rapid and far-reaching transitions in ...
Both pathways might result from the ability of oil-rich states to provide citizens with a combination of generous benefits and ... From 2018 onward, a discussion emerged concerning the potential for a resource curse related to critical materials for ... This could concern either countries with abundant renewable energy resources, such as sunshine, or critical materials for ... Some countries could still experience windfalls from critical materials for renewable energy technologies, but this depends on ...
"Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against ... around three weeks before arousal and the bears only leave their den once outside temperatures are at their lower critical ...
... pathway. This pathway normally regulates stress-induced cell death. It is also essential for development of nerval system by ... Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF, Maul GG (1999). "PML is critical for ... phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). Glucose breakdown ... The real apoptotic process starts after activating this pathway. Daxx does not activate JNK itself but rather the upstream JNK ...
Ten-m3 molecule is the first to be reported to regulate connectivity in the thalamostriatal pathway. Ten-m3 guides some of the ... Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon ... Similarly, there is a graded expression of Ten-m3 in the visual pathway, especially during embryonic and early postnatal ... m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision". PLOS Biology. 5 (9 ...
The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ... When a tumor blocks the pathway of the cerebrospinal fluid, this will cause headaches in the patient. Often when hydrocephalus ...
Its main pathway runs from the Pacific Ocean into the Banda Sea via the Celebes Sea, Makassar Strait and the Java and Flores ... The two straits are always critical for East Timor, both in relation to its own international trade and as routes for internal ... 17 By this and other ITF pathways, nutrient-rich water from the Pacific Ocean runs into the Indian Ocean,: 14 at a rate 50 ...
Databases Flow Chart of Metabolic Pathways at ExPASy IUBMB-Nicholson Metabolic Pathways Chart SuperCYP: Database for Drug- ... Ions are also critical for nerve and muscle function, as action potentials in these tissues are produced by the exchange of ... Cytochrome-Metabolism Archived 3 November 2011 at the Wayback Machine Metabolic pathways Metabolism reference Pathway Archived ... The oxidation pathway starts with the removal of the amino group by a transaminase. The amino group is fed into the urea cycle ...
Fukunaga K, Kudo T, Toh-e A, Tanaka K, Saeki Y (Jun 2010). "Dissection of the assembly pathway of the proteasome lid in ... Ramanathan MP, Curley E, Su M, Chambers JA, Weiner DB (Dec 2002). "Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr ... UPS proteolysis plays a major role in responses of cancer cells to stimulatory signals that are critical for the development of ... Mulder LC, Muesing MA (Sep 2000). "Degradation of HIV-1 integrase by the N-end rule pathway". The Journal of Biological ...
Once MAG (or Nogo) has bound to NgR, NgR activates the rho kinase (ROCK) pathway. The activation of the rho kinase pathway ... MAG is a critical protein in the formation and maintenance of myelin sheaths. MAG is localized on the inner membrane of the ...
An agonistic stimulus for the ICOS pathway during anti-CTLA-4 therapy resulted in an increase in efficacy that was about four ... "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary ... the proliferative defect is due either to ICOS-mediated IL-2 secretion or the activation of similar signaling pathways between ...
... signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, ... Cantell's and Tan's methods of making large amounts of natural interferon were critical for chemical characterisation, clinical ... In addition to the JAK-STAT pathway, IFNs can activate several other signaling cascades. For instance, both type I and type II ... Lin RJ, Liao CL, Lin E, Lin YL (September 2004). "Blocking of the alpha interferon-induced JAK-STAT signaling pathway by ...
... critical thinking, communication, collaboration and reflective thinking skills. VIBE electives offered are*: ACCORD Activism ... Crime Dance and Creative Movement Enviromaths Environmental Science Leichhardt TV Navigating Life Opportunities and Pathways in ...
Despite this discovery and the discovery of other pathways for synthesis of macrocyclic musks, compound of this class were not ... A critical literature review supplemented by own data". Science of the Total Environment. 651 (2): 2235-2246. doi:10.1016/j. ...
"Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis". International ... These acids eventually dissociate the hydroxyapatite in teeth once the acidity falls below the critical pH (pH 5.5). The ... Epple, Matthias; Meyer, Frederic; Enax, Joachim (2019-08-01). "A Critical Review of Modern Concepts for Teeth Whitening". ... Inhibition of metalloproteins slows down multiple signalling pathways and disrupts cellular organelles, subsequently producing ...
She believed that economic independence in the form of work for money was critical for this age, and felt that an arbitrary ... a Montessori classroom is to guide and consult students individually by letting each child create their own learning pathway. ... The 1914 critical booklet The Montessori System Examined by influential education teacher William Heard Kilpatrick limited the ...
... critical thinking, creativity, and compassion. We believe that education is a pathway to a more just society and sustainable ...
After dimerizing with TLR2, the NF-κB intracellular signalling pathway is activated, leading to a pro-inflammatory cytokine ... Lien E, Ingalls RR (January 2002). "Toll-like receptors". Critical Care Medicine. 30 (1 Suppl): S1-11. doi:10.1097/00003246- ... generally induces MyD88-dependent intracellular signalling pathway, which leads to nuclear translocation of nuclear factor-κB ( ...
Synaptic inhibition is critical for allowing the pre-Bötzinger complex to communicate with other respiratory centers in order ... or inhibit the NALCN channels depending on the neurotransmitter that binds the receptor and the specific signaling pathway that ... Serotonin plays a critical role in altering the pacemaker neurons involved in gasping and normal respiratory activity. Blocking ... The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs ...
Zinc is a critical component of the catalytic site of hundreds of kinds of different metalloenzymes in each human being. In its ... Thus zinc deficiency results in disruption of hundreds of metabolic pathways, causing numerous clinical manifestations, ...
Ward-Geiger LI, Silber GK, Baumstark RD, Pulfer TL (2005). "Characterization of Ship Traffic in Right Whale Critical Habitat". ... Raucci, Carlo (6 June 2019). "Three pathways to shipping's decarbonization". Global Maritime Forum. Retrieved 18 August 2022. " ...
... critical text analysis (intertextuality, actual events vs. narration of events, etc.) and practicing deep reading. Ability to ... fMRI is used to determine the specific neural pathways of activation across two conditions, narrative-level comprehension and ... create higher-level thinking opportunities for students by promoting critical and aesthetic thinking about the text. According ... suggesting a shared reliance with comprehension pathways. The scans also showed an enhanced temporal activation during ...
The S.A.T. Critical Reading mean was 572 and the Math mean was 568. The average ACT composite score was 22.8. There were 3 ... In the summer of 2007, the front of the school was remodeled, and a new building, Pathways Alternative School, was constructed ...
... evidence for a role for non-visual pathways in the phenomenon of developmental neuroplasticity during the postnatal critical ...
McNally, Richard J. (April 2007). "Betrayal trauma theory: a critical appraisal". Memory (Hove, England). 15 (3): 280-294, ... Delker, Brianna; Freyd, Jennifer (2014). "From Betrayal to the Bottle: Investigating Possible Pathways from Trauma to ...
It is critical that we receive an adequate amount of sleep each night. According to the Centers for Disease Control and ... Studies show that cortisol production correlates with heightened activity in the neural reward pathways of the brain, which ... While sleep is critical, it is no big surprise that many college students aren't reaching this threshold amount of sleep, and ... "Developmental pathways towards mood disorders in adult life: Is there a role for sleep disturbances?". Journal of Affective ...
"PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway". ... "Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development". Science Signaling ...
... Nat Neurosci. 2005 Feb;8(2):212-9. doi: ... Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. ... incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway ...
Mount Sinai researchers have identified a neural pathway through which the brain detects errors and guides subsequent ... Mount Sinai Researchers Uncover a Neural Pathway that is Critical to Correcting Behavioral Errors Relevant to Many Psychiatric ... Mount Sinai Researchers Uncover a Neural Pathway that is Critical to Correcting Behavioral Errors Relevant to Many Psychiatric ... The teams research, published February 19 in Neuron, also suggests that neurostimulation of this brain pathway could provide ...
Chronic abdominal pain critical pathways ‎ (← links). *Abdominal pain with hemodynamic instability critical pathways ‎ (← links ... Pages that link to "Abdominal pain duration critical pathways". ← Abdominal pain duration critical pathways ... Acute abdominal pain location critical pathways ‎ (← links). View (previous 50 , next 50) (20 , 50 , 100 , 250 , 500) Retrieved ... from "https://www.wikidoc.org/index.php/Special:WhatLinksHere/Abdominal_pain_duration_critical_pathways" ...
Web annex A: critical care pathway. World Health Organization. https://extranet.who.int/iris/restricted/handle/10665/351598. ...
... we present a conceptual model that documents pathways from polyvictimization to multiple youth ... Pathways from Polyvictimization to Youth Problem Behaviors: The Critical Role of School Engagement ... we present a conceptual model that documents pathways from polyvictimization to multiple youth problem behaviors, with school ...
CONTRO, Luiz. Pathways of psychodramatic research: between critical action research and intervention research. Rev. bras. ... Keywords : Critical action research; intervention research; psychodrama method; psychodramatic research. · abstract in ... Other publications followed on this pathway searching for specificities. Finally, in a new attempt to distinguish and ...
Text; Format: print Publication details: Genève : Organisation mondiale de la Santé, 2008Other title: .Title translated: Training modules for the syndromic management of sexually transmitted infections..Online access: Click here to access online , Click here to access online , Click here to access online , Click here to access online , Click here to access online , Click here to access online , Click here to access online , Click here to access online Availability: Items available for loan: WHO HQ (1)Call number: WC 142 2007TR-1. ...
PATHWAY: STRATEGIC AND CRITICAL THINKING. Make the transition to senior leadership and get the skills you need to make ... WHO IS THIS PATHWAY DESIGNED FOR?. Mid-to-senior level leaders who are looking to strengthen their strategic and critical ... IMS CURATED PATHWAYS. CERTIFICATE PROGRAM. The IMS curated pathways take the specific information you need to master a given ... PATHWAY: NEW & EMERGING LEADERS. Learn to become a leader who others will want to follow by first developing yourself as a ...
A monocyte-leptin-angiogenesis pathway critical for repair post-infection.. Kratofil, Rachel M; Shim, Hanjoo B; Shim, Raymond; ... monocytes have the capacity to convert to situationally specific macrophages that may have critical functions beyond infection ...
Characterization of the aberrant molecular pathways responsible for this malignancy provides a platform to discover alternative ...
Postdoctoral Position to Study Critical Pathways in Cancer Metabolism. A postdoctoral position is currently available at the ... and imaging with complementary molecular and biochemical methods to investigate metabolic pathways that are critical in cancer ... and critical discussions of innovative scientific concepts and evolving research projects. Previous postdoctoral scholars from ...
... and GSMA Outline Critical Pathways to Protect Telcos ... IBM, Vodafone, and GSMA Outline Critical Pathways to Protect ... Home Market Research IBM, Vodafone, and GSMA Outline Critical Pathways to Protect Telcos ...
The modelling on the pathway out of the pandemic; why critical care for women having heart attacks is being delayed; and ... Youve got it more than that, at 5. Its critical we get this right. What are the implications of this number? Its huge. ...
New paper demonstrates plausible pathways for formation of life-critical chemicals. Image credit: James McKay ... Alternative Pathway Could Change the Field of Pre-life Chemistry. A New Pathway to Lifes Origin. Sugar and the Origin of Life ... Scripps Research Team Proves Plausibility of New Primordial Pathway to Lifes Chemical Building Blocks. ... D. None of the above, but by another pathway not shown here.. ... Which pathway actually. accounts for the formation of a mixture ...
Energy Futures: Critical minerals, climate neutrality and transition pathways An exhibition on energy transitions and the ...
Crummer MB, Carter V. Critical pathways - the pivotal tool. J Cardiovasc Nurs 1993;7(4):30-7. CrossRefexternal icon PubMed ... Case management meetings involving CHWs allow the care team to understand critical pathways and issues patients face outside of ... Multidisciplinary care teams and interprofessional collaboration are critical to the success of health care reform. CHWs are ... Learning these pathways also allows the health care team to tailor their educational information for high-risk and high-need ...
Second, because enzymes critical to multiple DNA repair pathways require Fe-S clusters for their function, DNA repair enzymes ... often due to increased activity of DNA repair pathways. Sideroflexin 4 (SFXN4) is a little-studied inner mitochondrial membrane ... Second, because enzymes critical to multiple DNA repair pathways require Fe-S clusters for their function, DNA repair enzymes ... Why target SFXN4 instead of inhibiting an enzyme in a critical DNA repair pathway? Inhibiting proteins in a single DNA repair ...
Ways to restore critical pathways. *Genetic and genomic contributions to outcomes.. The All of Us Research Program (previously ...
Critical assessment of human metabolic pathway databases: a stepping stone for future integration. Research output: ...
Which pathogenetic pathways are critical, and can they be modulated therapeutically? Why does the disease continue to progress ... What is the relevance to human disease of the new pathways identified? What is the value of current animal models? What is the ...
Some recent examples include simulation studies focused on: the dynamics of tumor growth; the critical molecular pathways of ...
... at with or at high risk of developing severe allergic inflammation and anaphylaxis in order to identify specific pathways ... Define pathways critical for allergic inflammation and severe hypersensitivity reactions. Program Description. The prevalence ... ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans. J Exp Med. 2017 Mar 6;214(3):669-680. ... at with or at high risk of developing severe allergic inflammation and anaphylaxis in order to identify specific pathways ...
Its a really critical pathway for maintaining healthy neuronal functioning.. With that, Im just going to show you the slide ... Here you have ACTH in the adrenal gland, and epinephrine, and cortisol, which of course is very critical, depicted here, in ... All structures are very critical for mood and other types of regulation. This bed nucleus of the stria terminalis is an ... Then there are three different output pathways through which the updated signals like those learning signals are broadcast into ...
Retroviral DNA integration: reaction pathway and critical intermediates.. Li M, Mizuuchi M, Burke TR Jr, Craigie R.. EMBO J ( ...
Critical Pathways* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Clinical Pathway for Suicide Risk Screening in Adult Primary Care Settings: Special Recommendations Lynsay Ayer 1 , Lisa M ... Clinical Pathway for Suicide Risk Screening in Adult Primary Care Settings: Special Recommendations Lynsay Ayer et al. J Acad ... Suicide Risk Screening in Pediatric Hospitals: Clinical Pathways to Address a Global Health Crisis. Brahmbhatt K, Kurtz BP, ...
We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children ... Critical Pathways / standards* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Use of a rapid online Delphi process has made it possible to generate a national consensus pathway in a timely and cost- ... We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children ...
MeSH Terms: Clinical Decision-Making; Consensus; Critical Pathways/standards*; Decision Support Techniques*; Evidence-Based ... This Pathway is intended to be applicable in any setting where care for patients with NAFLD is provided, including primary care ... Abstract: Find AGAs NASH Clinical Care Pathway App for iOS and Android mobile devices at nash.gastro.org. Scan this QR code to ... Title: Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease. ...
Ethylene glycol-mediated tubular injury: identification of critical metabolites and injury pathways. Am J Kidney Dis 38(2):339- ... Critical clue to ethylene glycol poisoning. CMAJ 152(2):193-5.. *[IPCS] International Programme on Chemical Safety. 2002. ...
  • We have identified and biologically characterized several critical pathways that regulate allergic responses. (cincinnatichildrens.org)
  • Ubiquitin (yellow) can modify proteins and target them for degradation by the proteosome (right, violet) and can regulate pathways implicated in disease formation. (asbmb.org)
  • Seeking to reduce opioid use and improve patient safety at UTMC, Dr. Vanterpool and her colleagues implemented pain management pathways to standardize and streamline acute pain management at the hospital, which were innovative healthcare delivery system strategies initiated by Jerry Epps, MD, UTMC's CMO, and the medical clinical pathways development team. (beckershospitalreview.com)
  • Since implementing the pathways in 2016, UTMC has seen significant improvements in patient safety, staff communication and clinical accuracy. (beckershospitalreview.com)
  • The pathways also contain safeguards the ensure the accuracy of clinical pain diagnoses, according to Dr. Vanterpool. (beckershospitalreview.com)
  • Guidelines/Recommendations (revised 12/3/2015) clinical adj3 pathway).ti,ab,kw. (bvsalud.org)
  • or (clinical adj3 pathways).ti,ab,kw. (bvsalud.org)
  • Our Acute and Critical Care pathway incorporates issues such as health assessment, as well as the treatment of cardiac patients or patients in other acute settings. (gradireland.com)
  • During an interview with Becker's Hospital Review, Dr. Vanterpool spoke about the acute pain pathways, how they benefited the organization and key challenges associated with their implementation. (beckershospitalreview.com)
  • The unit focuses on the characterization of molecules, degradation pathways and defines critical quality attributes in a phase appropriate context. (bcm.edu)
  • The Glunde lab combines multinuclear magnetic resonance spectroscopy and imaging with complementary molecular and biochemical methods to investigate metabolic pathways that are critical in cancer development and response to therapy. (glundelab.org)
  • Their results expand our knowledge of the light-regulated protein quality control mechanism in photosynthetic organisms, which is critical for maintaining intracellular homeostasis during day-night alternation. (asbmb.org)
  • The course is delivered through the five specialist pathways long associated with the School of Nursing & Midwifery, enabling students from differing professional backgrounds to review their own practice and share balanced and critical findings that contribute towards improving the quality and efficiency of health and social care provision on a global level. (gradireland.com)
  • Insulin is a critical hormone that regulates sugar metabolism. (fda.gov)
  • In recognition of the increasing burden of diabetes and other NCDs as a major socio-economic challenge, Government of Uganda is scaling up critical care pathways for managing chronic diseases including diabetes up to primary health care level," said Hon. Margaret Muhanga, the Minister of State for Primary Health Care. (who.int)
  • These signaling pathways are all potential targets for anti-fibrotic treatments. (spandidos-publications.com)
  • Therefore, interrogation of potential organophosphorylation targets and aberrant phosphoprotein responses of critical signaling pathways in the STR were conducted. (cdc.gov)
  • Second, because enzymes critical to multiple DNA repair pathways require Fe-S clusters for their function, DNA repair enzymes and DNA repair itself are inhibited by reduction of SFXN4. (nature.com)
  • Dysregulation of ubiquitylation enzymes can lead to activation or deactivation of pathways implicated in diseases, including cancer and neurodegeneration. (asbmb.org)
  • In 2010, Congress, through the Biologics Price Competition and Innovation Act (BPCI Act), gave the FDA the authority to implement a pathway for approval of biosimilar and interchangeable products, to open biologics to competition, ultimately providing more treatment options, increasing access to lifesaving medications and potentially lowering health care costs. (fda.gov)
  • Students following this pathway will explore the latest evidence for the care and treatment of cancer patients, including palliative care. (gradireland.com)
  • or algorithms/ or care pathway.ti,ab,kw. (bvsalud.org)
  • 3 The term emergency, critical and operative care (ECO-) system is used here to refer to emergency, critical and operative care services and the mechanisms that ensure they are accessible to the people who need them. (who.int)
  • Students completing this pathway will often come from a Midwifery or Children's Nursing background. (gradireland.com)
  • These courses are specifically for Rotarians and Rotaractors and reflects projects from various paths in Pathways, already available to Toastmasters. (toastmasters.org)
  • If the central UN processes at COP27 fail to deliver the necessary support for small and vulnerable states, there are alternatives paths to change that speakers at our next Critical Conversation will consider. (commonwealthfoundation.com)
  • This structured program is based on current Pathways content, relying on self-assessment, independent study, applied projects, peer-to-peer feedback, and reflection. (toastmasters.org)
  • The pathways aim to promote the accurate assessment of pain, along with safe and effective pain management practices. (beckershospitalreview.com)
  • Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues. (nih.gov)
  • This gene provides instructions for making a protein called glypican 3, which blocks (inhibits) a developmental pathway called the hedgehog signaling pathway. (medlineplus.gov)
  • Target signaling pathways include the TGF-β/SMAD, TNF-α/NF-κB, leptin, IFN-γ/signal transducer and activator of transcription 3, adipoR/mitogen-activated protein kinase and peroxisome proliferator-activated receptor-α signaling pathways. (spandidos-publications.com)
  • While these courses take content from Pathways, they are not as in-depth as the Pathways projects. (toastmasters.org)
  • There is content included in Pathways projects that will be critical to the new Toastmaster's learning. (toastmasters.org)
  • the leadership development and communication courses would be more of a sample of the Pathways content. (toastmasters.org)
  • Chapters discuss current teaching and critical thought within the discipline, identify promising analytical approaches through which to research key aspects of social transformation, and investigate the relationship between sociology and its various publics. (e-elgar.com)
  • Based on the existing empirical literature and several unifying theories, we present a conceptual model that documents pathways from polyvictimization to multiple youth problem behaviors, with school engagement as a key mediator. (ed.gov)
  • It eventually leads to cirrhosis of the liver and liver failure, and it is a critical threat to the health and lives of patients with chronic liver diseases. (spandidos-publications.com)
  • A robust pathway for generic competition is critical to expanding drug access and promoting public health. (fda.gov)
  • Until recently, biologics lacked effective competition because there was no abbreviated pathway for bringing follow-on versions of biologics to market under the Public Health Service Act (PHS Act), similar to the generic pathway we have for small molecule drugs under created under the 1984 Hatch Waxman amendments to the Federal Food, Drug, and Cosmetic Act (FD&C Act). (fda.gov)
  • or Consensus Development Conferences as Topic/ or Consensus Development Conferences, NIH as Topic/or critical pathway/ or guidance.ti,ab. (bvsalud.org)
  • Module de formation pour la prise en charge syndromique des infections sexuellement transmissibles. (who.int)
  • Do Rotarians receive credit in Pathways if they complete the Rotary courses and then join Toastmasters? (toastmasters.org)
  • No. There is no credit provided in Pathways for completing the Rotary courses. (toastmasters.org)
  • The Glunde Lab is a diverse, international, and inclusive team of faculty, postdoctoral fellows, graduate students, undergraduate researchers, and staff members who engage in open, respectful, and critical discussions of innovative scientific concepts and evolving research projects. (glundelab.org)
  • The FDA can play an important role in encouraging competition by implementing a robust pathway for biosimilar competition. (fda.gov)
  • Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. (nih.gov)
  • A monocyte-leptin-angiogenesis pathway critical for repair post-infection. (bvsalud.org)
  • Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways. (nature.com)
  • Liver fibrosis is a continuous remodeling process involving numerous cells types, inflammatory cytokines and signaling pathways ( 5 , 6 ). (spandidos-publications.com)
  • Students completing this pathway will consider leadership and strategic issues in the global delivery of healthcare. (gradireland.com)
  • To mitigate any issues that could arise from a well-trained, but inexperienced workforce, UTMC placed safeguards in the pathways, including the pain red flags, opioid sedation scale and communication scripts to prompt critical thinking, explained Dr. Vanterpool. (beckershospitalreview.com)
  • This incisive Research Handbook explores the critical authors, texts, and research perspectives foundational to the discipline of public sociology. (e-elgar.com)
  • Through its participation in the Fenton reaction and other pathways, excess iron contributes to the oxidative fragility of cancer cells and heightens cancer cell susceptibility to agents that trigger oxygen radical-mediated cell death 3 . (nature.com)
  • Results of search for 'su:{Critical pathways. (who.int)
  • Traditionally, inhibition of AChE and the subsequent accumulation of acetylcholine (ACh) result in the activation of the cholinergic anti-inflammatory pathway. (cdc.gov)
  • But access to this critical drug can be increasingly difficult for these Americans. (fda.gov)
  • A pathway is chosen based on a patient's baseline level of need, as well as the experience of the provider. (beckershospitalreview.com)
  • Évaluation de l'implantation des guichets d'accès première ligne pour les patients orphelins en Montérégie et ses impacts. (usherbrooke.ca)