DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
CREST SyndromeTelangiectasisSyndromeRaynaud DiseaseScleroderma, LocalizedArteritisScleroderma, SystemicLiver Cirrhosis, BiliarySurgical InstrumentsAutoantibodiesScleroderma, DiffuseLymphangioleiomyomatosisMultiple SclerosisScleroderma, LimitedHistiocytosis, Langerhans-Cell
CREST Syndrome
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
Telangiectasis
Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.
Syndrome
A characteristic symptom complex.
Raynaud Disease
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
Scleroderma, Localized
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Arteritis
INFLAMMATION of any ARTERIES.
Scleroderma, Systemic
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Liver Cirrhosis, Biliary
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Surgical Instruments
Hand-held tools or implements used by health professionals for the performance of surgical tasks.
Autoantibodies
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Scleroderma, Diffuse
A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.
Lymphangioleiomyomatosis
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Scleroderma, Limited
The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.
Histiocytosis, Langerhans-Cell
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.

Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases. (1/32)

A duplication in the fibrillin-1 gene has been implicated as the cause of the tight skin 1 (tsk1) phenotype, an animal model of scleroderma or systemic sclerosis (SSc). In addition to the production of abnormal fibrillin-1 protein, the tsk1 mouse also produces autoantibodies to fibrillin-1. Among a population of Choctaw Native Americans with the highest prevalence of SSc yet described, a chromosome 15q haplotype containing the fibrillin-1 gene has been strongly associated with SSc. With a recombinant human fibrillin-1 protein, autoantibodies to fibrillin-1 were detected in the sera of Native American SSc patients that correlated significantly with disease. Abs to fibrillin-1 also were detected in sera from Japanese, Caucasian, and African-American SSc patients. Compared with other ethnic groups, Japanese and Native American SSc patients had significantly higher frequencies of anti-fibrillin-1 Abs. Sera from patients with diffuse SSc, calcinosis, Raynaud's, esophageal dysmotility, sclerodactyly, and telangiectasias syndrome and mixed connective tissue disease also had significantly higher frequencies of anti-fibrillin-1 Abs than sera from controls or patients with other non-SSc connective tissue diseases (lupus, rheumatoid arthritis, and Sjogren's syndrome). Ab specificity for fibrillin-1 was demonstrated by the lack of binding to a panel of other purified autoantigens. The results presented demonstrate for the first time the presence of high levels of anti-fibrillin-1 Abs in a significant portion of patients with SSc.  (+info)

Phlebosclerosis of the colon with positive anti-centromere antibody. (2/32)

A 56-year-old woman with symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enema study. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. No cell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CREST syndrome were observed. We therefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CREST syndrome.  (+info)

The mammalian centromere: structural domains and the attenuation of chromatin modeling. (3/32)

The centromere-kinetochore complex can be divided into distinct domains based on structure and function. Previous work has used CREST auto-antibodies with various microscopic techniques to map the locations of proteins within the centromere-kinetochore complex and to analyze the maturation of prekinetochores before mitosis. Here we have focused on the centromere-specific histone Centromere Protein (CENP)-A and its spatial relationship to other histones and histone modifications found in condensed chromatin. We demonstrate that the phosphorylation of histone H3 is essentially excluded from a specific region of centromeric chromatin, defined by the presence of CENP-A. Interspersion of CENP-B with phosphorylated H3 in the inner centromere indicates that the exclusion of H3 modification is not a general property of alpha-satellite DNA. We also demonstrate that these regions are functionally distinct by fragmenting mitotic chromatin into motile centromere-kinetochore fragments that contain CENP-A with little or no phosphorylated H3 and nonmotile fragments that contain exclusively phosphorylated H3. The sequence of CENP-A diverges from H3 in a number of key residues involved in chromosome condensation and in transcription, potentially allowing a more specialized chromatin structure within centromeric heterochromatin, on which kinetochore plates may nucleate and mature. This specialized centromere subdomain would be predicted to have a very tight and static nucleosome structure as a result of the absence of H3 phosphorylation and acetylation.  (+info)

Clinical, serological and genetic study in patients with CREST syndrome. (4/32)

OBJECTIVE: To assess the clinical, serological and genetic features of Japanese patients with CREST syndrome. PATIENTS AND METHODS: Clinical features, autoantibodies and human histocompatibility leukocyte antigen (HLA) typing were studied in thirty patients with CREST syndrome, including 29 females and one male, with a mean age of 59.0 years (ranging from 40 to 76 years). RESULTS: Interstitial pneumonia on chest X-ray and renal involvement were rare. Mitral regurgitation and tricuspid regurgitation were present in 56.7% and 76.7%, respectively. Sjoren's syndrome (SS) and primary biliary cirrhosis (PBC) were highly associated, however the positivity of the marker antibodies to those syndromes, such as anti-SSA, anti-SSB, anti-mitochondrial (AMA) and anti-smooth muscle autoantibodies were less frequent than that of primary SS and PBC without the other autoimmune diseases. The histological findings of PBC were all early stages in Scheuer's classification. HLA-Cw6 were associated with CREST-PBC overlap syndrome (p<0.05). However the HLA antigen was not correlated with CREST syndrome, and the frequency of HLA-DR2 between CREST syndrome with or without PBC was significantly different (p<0.01). CONCLUSION: It was suggested that there was a genetic difference between CREST syndrome alone and CREST-PBC overlap syndrome and there were differences (the positivity of AMA and the severity of bile duct lesion) between PBC and CREST-PBC overlap syndrome.  (+info)

Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome? (5/32)

OBJECTIVE: We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis. RESULTS: Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy. CONCLUSIONS: From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.  (+info)

Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome. (6/32)

A 58-year-old woman with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome presented with slowly progressive renal dysfunction. She was normotensive with normal plasma renin activity and lacking symptoms of vasculitis. Mild proteinuria was of tubular origin, but serological tests and an absence of sicca symptoms excluded the possibility of Sjogren's syndrome. Light microscopic study of renal biopsy showed interstitial fibrosis with ectasia and degeneration of proximal tubule and lymphocyte infiltration. There were no remarkable changes in the glomeruli. Chromatographic analysis of the Chinese herbs regimen that she had been taking for several years demonstrated aristolochic acid. She was diagnosed as Chinese herbs nephropathy. Therapy with oral prednisolone was markedly effective in improving renal function and anemia. To our knowledge, this is the first report of Chinese herbs nephropathy complicating connective tissue disease. It is important to consider the possibility of Chinese herbs nephropathy when patients treated with Chinese herbs develop renal dysfunction.  (+info)

Induction of kinetochore-positive and kinetochore-negative micronuclei in CHO cells by ELF magnetic fields and/or X-rays. (7/32)

To test the genotoxic effects of extremely low frequency (ELF) magnetic fields, the induction of micronuclei by exposure to ELF magnetic fields and/or X-rays was investigated in cultured Chinese hamster ovary (CHO) cells, using the cytokinesis block method. Micronuclei derived from acentric fragments or from whole chromosomes were evaluated by immunofluorescent staining using anti-kinetochore antibodies from the serum of scleroderma (CREST syndrome) patients. A 60 Hz ELF magnetic field at 5 mT field strength was applied, either before or after 1 Gy X-ray irradiation or without additional X-ray irradiation. No statistically significant difference in the frequency of micronuclei in CHO cells was observed between a sham exposure (no exposure to an ELF magnetic field) and a 24 h ELF magnetic field exposure. Exposure to an ELF magnetic field for 24 h before X-ray irradiation or for 18 h after X-ray irradiation did not affect the frequency of X-ray-induced micronuclei. However, the number of kinetochore-positive micronuclei was significantly increased in the cells subjected to X-ray irradiation followed by ELF magnetic field exposure, but not in the cells treated with ELF magnetic field exposure before X-ray irradiation, compared with exposure to X-rays alone. The number of spontaneous kinetochore-positive and kinetochore-negative micronuclei was not affected by exposure to an ELF magnetic field alone. Our data suggest that exposure to an ELF magnetic field has no effect on the number of spontaneous and X-ray-induced micronuclei. However, ELF magnetic field exposure after but not before X-ray irradiation may somehow accelerate X-ray-induced lagging of whole chromosomes (or centric fragments) in CHO cells.  (+info)

Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. (8/32)

Centrosome is the major microtubule organizing center in mammalian cells that plays a critical role in a variety of cellular events by the microtubule arrays emanating from it. Despite its significance, the molecular mechanisms underlying the structure and function of the centrosome are still not clear. Herein we describe the identification of three isotypes of human ninein by expression library screening with autoimmune sera from CREST patients. All three ninein isotypes exhibit centrosomal localization throughout the cell cycle when GFP-tagged fusion proteins are expressed transiently in mammalian cells. Construction of serial deletions of GFP-tagged ninein reveals that a stretch of three leucine zippers with a flanking sequence is required and sufficient for centrosomal targeting. Overexpression of ninein results in mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules. In these cells, nucleation of microtubules from the centrosome is also inhibited. These results thus suggest a regulatory role for ninein in microtubule nucleation.  (+info)

Upper Gastrointestinal Bleeding (Watermelon Stomach) in a Patient With Limited Scleroderma (CREST Syndrome) | Reumatología...Upper Gastrointestinal Bleeding (Watermelon Stomach) in a Patient With Limited Scleroderma (CREST Syndrome) | Reumatología...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
http://reumatologiaclinica.org/en/upper-gastrointestinal-bleeding-watermelon-stomach-/articulo/S2173574317300904/
Upper Gastrointestinal Bleeding (Watermelon Stomach) in a Patient With Limited Scleroderma (CREST Syndrome) | Reumatología...Upper Gastrointestinal Bleeding (Watermelon Stomach) in a Patient With Limited Scleroderma (CREST Syndrome) | Reumatología...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
http://reumatologiaclinica.org/en/hemorragia-digestiva-alta-estomago-sandia-/articulo/S2173574317300904/
About a subcutaneous calcificationAbout a subcutaneous calcification
We report a case of 62-year-old Tunisian woman with a 10-year history of a CREST syndrome (systemic sclerosis meeting the criteria of the CREST syndrome of the 1980 American College of Rheumatology classification for raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Her daughter is treated in neurology for myasthenia gravis. Our patient presents a 5-month history of increasing inflammatory right thumb pain concomitant with the discovery of a subcutaneous hard mass (A). Radiographs of her thumb showed a sub-cutaneous calcification (as another part of the CREST syndrome criteria) (B). X-rays of hands found an acro-osteolysis (C). In the CREST syndrome, the calcific deposits can be subclinical. But, when symptomatic, it becomes painful, tender and an inflammatory reaction can occur facing the calcinosis.
http://www.panafrican-med-journal.com/content/article/29/9/full/
CREST syndrome - WikipediaCREST syndrome - Wikipedia
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder. The acronym CREST refers to the five main features: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension. CREST causes thickening and tightening of the skin with deposition of calcific nodules (calcinosis). Raynauds phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. Stress and cold temperature induce an exaggerated vasoconstriction of the small arteries, arterioles, and thermoregulatory vessels of the skin of the digits. Clinically this manifests as a white-blue-red transitions in skin ...
https://en.wikipedia.org/wiki/CREST_syndrome
Crest Syndrome Symptoms, Diagnosis & Treatment Options | MedicalAdvicePlus.com
Crest syndrome is an acronym for Calcinosis; Reynaudssyndrome; Esophagealdysmotility; Sclerodactyly and Telangiectasia. It is also known as Limited
http://medicaladviceplus.com/crest-syndrome-symptoms-diagnosis-treatment-options/
BALLOON DILATATION IN THE TREATMENT OF ESOPHAGEAL STRICTURE IN PATIENTS WITH CREST SYNDROME | Vrach (The Doctor)BALLOON DILATATION IN THE TREATMENT OF ESOPHAGEAL STRICTURE IN PATIENTS WITH CREST SYNDROME | Vrach (The Doctor)
The paper outlines the experience with minimally invasive surgical technologies for esophageal injury in the presence of systemic connective tissue disease. The clinical example clearly demonstrates the importance of timely diagnosis of esophageal stricture in CREST syndrome and suggests that it is necessary to treat these difficult-to-treat patients at large multiprofile hospitals ...
https://vrachjournal.ru/en/25877305-2015-03-11
CREST Syndrome Misdiagnosis | Medical Malpractice HelpCREST Syndrome Misdiagnosis | Medical Malpractice Help
CREST syndrome is related to antibodies that combat centromeres (regions of DNA chromosomes) like ones in the kidneys and lungs. Characterized as an
https://www.medicalmalpracticehelp.com/misdiagnosis/crest-syndrome/
Crest Syndrome Thrombocytopenia
Tips to help with your thrombocytopenia: Crest Syndrome Thrombocytopenia. My thrombocytopenia, Online resources for thrombocytopenia.
http://mythrombocytopenia.net/crest-syndrome-thrombocytopenia/
Answer to Medical Mystery Monday #55 - M.D. to beAnswer to Medical Mystery Monday #55 - M.D. to be
The answer to yesterdays mystery is … limited scleroderma (a.k.a. CREST syndrome)! Great job Priscilla, Kmu, American Girl Mommy, Erin, Rich S, guest, OB1, Phung, Shelly Langlois, mabel, vor120806, Kimberly Helton, CB, Kelly, ColorMaven, Jerry Skrocki, Amanda, Michelle, Tina M., Angelita, ER SEC, Mary, todd dombrowski, JP3, kim labounty, Dazed & Confused, JB, and PJ.. Ill give partial credit to those who named one component of CREST syndrome, Raynauds phenomenon: D2, Patti Ann, Carol, MG, Gracie287, GetAClue, Zach A., Tara Naz, Robert Jones, the other Naomi, Shannon Vincent, Martha, sallad, Michele Liguori, Veronica, Deborah Cote, JP, and GG.. CREST syndrome, or limited cutaneous systemic scleroderma, is an autoimmune disease that causes scarring of different tissues in the body, most notably the skin. The cause of the disease is unknown, but it is likely some combination of genetic factors and environmental triggers. First, inflammatory white blood cells infiltrate the skin and ...
http://blog.timesunion.com/mdtobe/answer-to-medical-mystery-monday-55/1663/
Scleroderma | Lima Memorial Health SystemScleroderma | Lima Memorial Health System
The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis, scleroderma. CREST is an acronym for the clinical features that are seen in a patient with this disease. The C stands for calcinosis, where calcium deposits form under the skin on the fingers or other areas of the body. The R stands for Raynauds phenomenon, spasm of blood vessels in the fingers or toes in response to cold or stress. The E represents esophageal dysmotility, which can cause difficulty in swallowing. The S is for sclerodactyly, tightening of the skin causing the fingers to bend. Finally, the letter T is for telangiectasia, dilated vessels on the skin of the fingers, face, or inside of the mouth. Usually only 2 of the 5 symptoms of the CREST syndrome is necessary to be diagnosed with the disease. ...
https://www.limamemorial.org/health-library/HIE%20Multimedia/1/000429
NewYork-Presbyterian Queens - Scleroderma
CREST syndrome A less severe form of scleroderma is called CREST.. The CREST syndrome represents symptoms including calcium skin deposits; Raynauds phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous); esophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach); sclerodactyly (skin damage on fingers); and telangiectasia (spider veins), limits skin damage to the fingers.. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure.. ...
http://www.nyhq.org/diw/Content.asp?PageID=DIW000066&language=Korean
AboutBFS.com • View topic - Crest syndrome/ scleroderma
Without Raynauds you cannot diagnose Scleroderma. I think it is completely unprofessional for your doctor to say you have this, or even suspect it - since hes not a rheumatologist. If you dont have Raynauds you dont have this... Something like 98% of those with Scleroderma have very severe Raynauds. Multiple people on this board have Raynauds, but were talking severe Raynauds where your fingers turn mutliple colors and you literally have to put them under warm water to get them back to normal ...
http://www.aboutbfs.com/forums/viewtopic.php?p=163515
Chapter 19: Autoimmune Diseases, Sjogrens Syndrome and Progressive Systemic Sclerosis - Labpedia.netChapter 19: Autoimmune Diseases, Sjogrens Syndrome and Progressive Systemic Sclerosis - Labpedia.net
Morphology. Virtually all organs are involved.. 1. Skin. Bundles of the collagen bind the skin to the underlying tissue.. Changes take place in three stages.. Stage I: There is edema which is non-pitting and microscopically there is edema, perivascular lymphocytic infiltrate, capillaries and small arteries are thickened, and there is collagen deposition.. Stage II: Due to an increase in collagen formation, wrinkles disappear. The epidermis becomes thin.. Stage III: This is the atrophic stage where claw-like hand, the face is drawn and mask. Microscopically there is atrophy of the epidermis and increase collagen. Calcification may be seen.. In the late stages due to loss of blood supply ulceration may take place.. Skin involvement may be a part of CREST syndrome. Where:. C = Calcinosis.. R = Raynauds phenomenon.. E = Esophageal involvement.. S = sclerodactyly (localized sclerosis of the finger).. T = Telangiectasia.. 2. Gastrointestinal. Gastrointestinal involvement is seen ,50% of the cases. ...
https://www.labpedia.net/elementary-immunology/chapter-19-autoimmune-diseases-sjogrens-syndrome-and-progressive-systemic-sclerosis/
Images of Scleroderma SymptomsImages of Scleroderma Symptoms
Main page of ISN Scleroderma Symptom Photo Repository. Pictures include images of amputations, calcinosis, hand contractures, CREST syndrome, gangrene, Raynauds, sclerodactyly, and telangeiectasia.
https://www.sclero.org/scleroderma/symptoms/photos/a-to-z.html
Symptoms of Scleroderma: Sclerodactyly - Scleroderma NewsSymptoms of Scleroderma: Sclerodactyly - Scleroderma News
In this video from Scleroforums, learn more about Scleroderma and Sclerodactyly from Amanda Thorpe for the nonprofit International Scleroderma Network.
https://sclerodermanews.com/2016/01/29/symptoms-of-scleroderma-sclerodactyly/
Phenomenon Of Heart Disease
The Raynauds phenomenon is named after the French doctor who first wrote about in the 1850. There is Raynauds phenomenon or simply Raynauds is a disorder to the characterized by decreased blood flow usually to the fingers and less frequently to the ears, toes, nipples, knees, or nose. The Raynauds can occur alone or may occur with other diseases. The diseases most frequently by the associated with Raynauds are autoimmune or connective tissue diseases, among others, such as the followings are systemic lupus erythematous and scleroderma and CREST syndrome, Buergers disease, polymyositis, Sjogrens syndrome, occlusive vascular disease, rheumatoid arthritis, cryoglobulinemia. They are one theory links blood disorders to the characterized by increased platelets or red blood cells that may increase the blood thickness. The phenomenon of heart disease will be varying from one person to another person in the real world.. Risk Factor:. The risk of factor is anything that may be increases a persons ...
http://www.leschaisesdenina.com/category/phenomenon-of-heart-disease
Two Halves - Scleroderma FoundationTwo Halves - Scleroderma Foundation
By: Connie ODonnell How Scleroderma and Paraplegia can have a bright spot in the lives of one couple.. I was not diagnosed with Scleroderma Crest Syndrome until I was into my 50s, but suffered from Raynauds and painful finger ulcers for many years. There isnt a photo of me that I am not sporting bandaids on my fingers. Finally these drove me to a doctor, then a wound care facility. I suffered through much painful debriding until finally I had to have my index fingers amputated. I am an artist and initially this procedure was devastating. However, over the years, my fingers have stiffened and become bent, but I have managed to adapt. I am now almost 65 and still draw and paint, and can diaper a grand child with some difficulty. Six years ago my husband suffered a spinal cord injury and is paralyzed just below his arms. We consider ourselves lucky. He is the hands and I am the legs in our relationship, so together we are a whole.....or somewhat close to one.. ...
http://scfo.convio.net/site/News2?page=NewsArticle&id=5181
Scleroderma - WikipediaScleroderma - Wikipedia
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs.[2][6][8] The disease can be either localized to the skin or involve other organs, as well.[2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure.[1] One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynauds syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small, dilated blood vessels.[1] The cause is unknown, but it may be due to an abnormal immune response.[2] Risk factors include family history, certain genetic factors, and exposure to silica.[3][4][5] The underlying mechanism involves the abnormal growth of connective tissue, which is believed to be the result of the immune system attacking healthy tissues.[6] Diagnosis is based on symptoms, supported by a skin biopsy or blood tests.[6] While no ...
https://en.wikipedia.org/wiki/Scleroderma
Omega-News: 18 März 2006Omega-News: 18 März 2006
Extremely low-frequency (ELF) magnetic fields have previously been shown to affect conformation of chromatin, cell proliferation, and calcium metabolism. Possible mutagenic and carcinogenic effects of ELF have also been discussed and tested. In this study, intrachromosomal recombination in the hprt gene after exposure to ELF magnetic field was investigated using the SPD8 recombination assay. SPD8 cells, derived from V79 Chinese hamster cells were exposed to ELF at a specific combination of static and ELF magnetic fields, that has been proven to have effects on chromatin conformation in several cell types. The genotoxic agent camptothecin (CPT) was used either as a positive control or simultaneously with ELF. We also analysed the effect of ELF and CPT on chromatin conformation with the anomalous viscosity time dependence (AVTD) technique, cell growth kinetics, and cell survival with clonogenic assay. DNA fragmentation was analysed by pulsed field gel electrophoresis (PFGE). ELF did not induce ...
https://omega.twoday.net/20060318/
Cataract, Alopecia, Sclerodactyly - Latest News and Events
Are you looking for disease information or support? Simply type in the name of a disease or condition and Disease InfoSearch will locate quality information from a database of more than 13,000 diseases and thousands of support groups and foundations.
https://diseaseinfosearch.org/Cataract%2C+Alopecia%2C+Sclerodactyly/1152/news
https://www.medicalnewstoday.com/articles/319608.phphttps://www.medicalnewstoday.com/articles/319608.php
Learn all about sclerodactyly, a condition that can cause the hands to take on a claw shape. This article looks at the symptoms, causes, and treatment.
https://www.medicalnewstoday.com/articles/319608.php
RAB11FIP3 - PCR Primer Pair - SYBR | PrimePCR | Bio-RadRAB11FIP3 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad
Gene Information Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation targeting and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al. 2001 [PubMed 11495908]).[supplied by OMIM Mar 2008]. ...
https://www.bio-rad.com/en-us/prime-pcr-assays/assay/qhsacid0009271-primepcr-sybr-green-assay-rab11fip3-human
Calcinosis Cutis (Benign Cutaneous Calcification, Benign Nodular Calcification) - Clinical AdvisorCalcinosis Cutis (Benign Cutaneous Calcification, Benign Nodular Calcification) - Clinical Advisor
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. pathophysiology and management. Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy. Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
https://www.clinicaladvisor.com/home/dermatology/calcinosis-cutis-benign-cutaneous-calcification-benign-nodular-calcification/
Scleroderma Program: Raynaud PhenomenonScleroderma Program: Raynaud Phenomenon
Raynaud phenomenon is known to occur in around 10% of the healthy female population and in around 5% of men. In the vast majority of cases, the blood vessels show no evidence of damage. In this case - so called Primary Raynaud phenomenon - the issue appears to be exaggerated spasm of healthy blood vessels.. Raynaud phenomenon is also the most common first symptom of scleroderma and is an important feature in other rheumatologic illnesses such as lupus. In this situation, the blood vessels are damaged and the opening for blood flow is much reduced. Raynaud episodes in scleroderma may reflect normal blood vessel constriction in response to cold superimposed on the narrow plumbing.. Blood flow to the fingers in normal health is around 40 times as much as is needed for oxygen supply and tissue nutrition. When the body is hot, blood flow increases to the hands so as to dissipate heat. This is much like a dog panting on a hot day. Conversely, when the body is cold, it is normal to reduce blood flow to ...
http://www.med.umich.edu/scleroderma/patients/raynauds.htm
Doctors Gates: Antinucleolar antibody in diagnosis of Scleroderma
The symptoms of Raynauds phenomenon, arthralgia, and dysphagia point toward the diagnosis of scleroderma. Scleroderma, or systemic sclerosis, is characterized by a systemic vasculopathy of small and medium-sized vessels, excessive collagen deposition in tissues, and an abnormal immune system. It is an uncommon multisystem disease affecting women more often than men. There are two variants of scleroderma ;a relatively benign type called the CREST syndrome C-calcinosis.R- raynaud phen. E- esophagal dysmotility.S-sclerodactyly.T-talangiectasia and a more severe, diffuse disease ...
http://doctorsgates.blogspot.gr/2011/07/antinucleolar-antibody-in-diagnosis-of.html
CALCINOSIS CUTIS TREATMENT PDF
CALCINOSIS CUTIS TREATMENT PDF - BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but theres still no consensus on treatment. OBJECTIVES.
https://puppy-party.info/calcinosis-cutis-treatment-21/
Calcinosis cutis: Etiology and patient evaluationCalcinosis cutis: Etiology and patient evaluation
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
https://www.uptodate.com/contents/calcinosis-cutis-etiology-and-patient-evaluation
ANA Screen,IFA, Reflex Titer/Pattern,and Reflex to Multiplex 11 Ab CascadeANA Screen,IFA, Reflex Titer/Pattern,and Reflex to Multiplex 11 Ab Cascade
Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogrens syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE.
http://www.questdiagnostics.com/testcenter/TestDetail.action?tabName=RelatedGuides&ntc=16814
Basis of deafness in Waardenburg syndrome | Disease Models & MechanismsBasis of deafness in Waardenburg syndrome | Disease Models & Mechanisms
The Waardenburg syndromes (WS) are rare genetic disorders described classically as neural crest syndromes and characterized by deafness and pigmentation abnormalities. WS type IV (WS4) is attributed to mutations in the SOX10 gene, which regulates pigment cell development. Here, Kirsten Dutton and colleagues study otic vesicle development using a zebrafish model of WS4, the colourless/sox10 mutant. WS4 patients and mutant fish display a similar spectrum of abnormalities in the ear, pigment cells and enteric neurons. Additionally, the researchers found that only a few neural crest cells contribute to the developing zebrafish ear, and therefore are unlikely to be wholly responsible for the resulting auditory deficits. Their work helps explain the origin of inner ear deficits that lead to hearing loss and vestibular problems in WS4 patients.. Page 68. ...
http://dmm.biologists.org/content/2/1-2/1.4
Raynaud Syndrome Causes & Reasons - SymptomaRaynaud Syndrome Causes & Reasons - Symptoma
Raynaud Syndrome Symptom Checker: Possible causes include Raynaud Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
https://www.symptoma.com/en/ddx/raynaud-syndrome
Search | NIAMSSearch | NIAMS
Qué es el fenómeno de Raynaud? El fenómeno de Raynaud es una enfermedad que afecta los vasos sanguíneos. Si usted tiene el fenómeno de Raynaud, tiene periodos llamados episodios cuando el cuerpo no envía suficiente sangre a las manos y los pies. Los episodios generalmente ocurren cuando la persona tiene frío o se siente estresada. Durante un episodio, los dedos de las manos y los pies pueden sentirse muy fríos o entumecidos. El fenómeno de Raynaud también se conoce como la enfermedad de Raynaud o el síndrome de Raynaud ...
https://www.niams.nih.gov/search?search=What%20is%20Raynaud%E2%80%99s%20Phenomenon%3F&type=All&media=All&f%5B0%5D=diseases_and_conditions%3A212&f%5B1%5D=diseases_and_conditions%3A213&f%5B2%5D=diseases_and_conditions%3A228&f%5B3%5D=diseases_and_conditions%3A252&f%5B4%5D=diseases_and_conditions%3A291&f%5B5%5D=diseases_and_conditions%3A309
Search | NIAMSSearch | NIAMS
Qué es el fenómeno de Raynaud? El fenómeno de Raynaud es una enfermedad que afecta los vasos sanguíneos. Si usted tiene el fenómeno de Raynaud, tiene periodos llamados episodios cuando el cuerpo no envía suficiente sangre a las manos y los pies. Los episodios generalmente ocurren cuando la persona tiene frío o se siente estresada. Durante un episodio, los dedos de las manos y los pies pueden sentirse muy fríos o entumecidos. El fenómeno de Raynaud también se conoce como la enfermedad de Raynaud o el síndrome de Raynaud ...
https://www.niams.nih.gov/search?search=What%20is%20Raynaud%E2%80%99s%20Phenomenon%3F&type=All&media=All&f%5B0%5D=audience%3A50&f%5B1%5D=diseases_and_conditions%3A199&f%5B2%5D=diseases_and_conditions%3A228&f%5B3%5D=diseases_and_conditions%3A230&f%5B4%5D=diseases_and_conditions%3A238&f%5B5%5D=diseases_and_conditions%3A309
Metastatic calcinosis cutis Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comMetastatic calcinosis cutis Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Metastatic calcinosis cutis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
http://www.rightdiagnosis.com/m/metastatic_calcinosis_cutis/intro.htm
Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ): Costs for treatment #151501 in Germany |...Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ): Costs for treatment #151501 in Germany |...
Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ) (costs for program #151501) ✔ University Hospital Münster ✔ Department of Gerneral Internal Medicine, Nephrology, Hypertension Diseases and Rheumatology (Medical Department D) ✔ BookingHealth.com
https://bookinghealth.com/university-hospital-m-nster/treatment-programs/151501-diagnosis-and-conservative-treatment-of-raynauds-syndrome-raynaud-disease-.html
Diagnosis of raynauds syndrome (Raynaud disease ): Costs for treatment #242505 in Germany | BookingHealthDiagnosis of raynauds syndrome (Raynaud disease ): Costs for treatment #242505 in Germany | BookingHealth
Diagnosis of raynauds syndrome (Raynaud disease ) (costs for program #242505) ✔ University Hospital Hamburg-Eppendorf ✔ Department of Pediatrics ✔ BookingHealth.com
https://bookinghealth.com/university-hospital-hamburg-eppendorf/diagnostic-programs/242505-diagnosis-of-raynauds-syndrome-raynaud-disease-.html
Raynauds disease legal definition of Raynauds diseaseRaynauds disease legal definition of Raynauds disease
Definition of Raynaud's disease in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Raynaud's disease? Meaning of Raynaud's disease as a legal term. What does Raynaud's disease mean in law?
https://legal-dictionary.thefreedictionary.com/Raynaud
Raynaud and Seiver Disease | Foot HealthCare AssociatesRaynaud and Seiver Disease | Foot HealthCare Associates
Raynaud and Seiver Disease affect the feet, but in different ways. Raynauds Disease causes spasms, while Seivers Disease can mimic Achilles tendonitis.
https://www.michiganpodiatry.com/foot-diseases/raynaud-seiver-disease/
Dr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Geneseo Republic - Geneseo, IL - Geneseo, ILDr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Geneseo Republic - Geneseo, IL - Geneseo, IL
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
http://www.geneseorepublic.com/article/20121011/NEWS/121019789
Dr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Ionia Sentinel - Standard-Ionia, MI - Ionia, MIDr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Ionia Sentinel - Standard-Ionia, MI - Ionia, MI
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
http://www.sentinel-standard.com/article/20121011/NEWS/121019867
Dr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - The Kansan - Newton, KS - Newton, KSDr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - The Kansan - Newton, KS - Newton, KS
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
http://www.thekansan.com/article/20121011/NEWS/121019824/1636/LIFESTYLE
Raynauds PhenomenonRaynauds Phenomenon
This page includes the following topics and synonyms: Raynauds Phenomenon, Raynauds Syndrome, Raynaud Disease, Raynaud Phenomenon, Raynaud Syndrome.
https://fpnotebook.com/mobile/Rheum/CV/RyndsPhnmn.htm
Milia-Like Idiopathic Calcinosis Cutis: When Waiting Is the Best Option | My Demons
A 6-month-old boy was referred to our department for the presence of diffuse multiple whitish, pseudomilia-like papules on the skin of the extremities since birth. The patient was well-appearing, and afebrile, with normal vital signs. The examination revealed multiple, yellow-white, firm, small, subcutaneous nodules and papules (Figure 1, A-C). The lesions were present only on the extremities, arms and legs. The lesions were in different stages, with a precise evolution process toward extrusion of a whitish material, erosion and healing (Figure 1, A ...
https://mydemons.org/milia-like-idiopathic-calcinosis-cutis-when-waiting-is-the-best-option/
Dr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Middletown Transcript - Middletown, DEDr. Jeff Hersh: Blue fingers symptom of Raynaud phenomenon - News - Middletown Transcript - Middletown, DE
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.. Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be ...
https://www.middletowntranscript.com/article/20121009/NEWS/310099992
Language Misunderstandings - latimesLanguage Misunderstandings - latimes
Mr. Raynaud, a recent immigrant from France, finds employment as a high school literature teacher in the U.S. One day, a female student bursts into tears in the middle of class. Raynaud walks over
http://articles.latimes.com/1998/apr/11/local/me-38145
PF-00489791 For The Treatment Of Raynaud's - Full Text View - ClinicalTrials.govPF-00489791 For The Treatment Of Raynaud's - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/ct2/show/NCT01090492?term=Raynaud
A Guide to Raynauds PhenomenonA Guide to Raynauds Phenomenon
Raynaud's phenomenon, a disorder that affects the blood vessels in the fingers, toes, ears, and nose, can occur as a primary or secondary condition.
https://www.verywell.com/guide-to-raynauds-phenomenon-190288
Profil miozita - Blot - la Medic.roProfil miozita - Blot - la Medic.ro
Laborator Synevo. Informaţii generale şi recomandari pentru determinarea profilului miozita. Miopatiile inflamatorii idiopatice reprezinta un grup de afectiuni caracterizate prin slabiciunea musculaturii proximale a membrelor, atrofie musculara, semne biochimice şi electromiografice de leziune musculara, anomalii histologice, modificari cutanate caracteristice. Apar cu o incidenta de 0,1-1/100 000 locuitori/an şi sunt mai frecvente la femei. Din acest grup fac parte: polimiozita, dermatomiozita, miozita cu corpi de incluziune, miozita asociată cu neoplazie (sindrom paraneoplazic) şi miozita asociată cu alte boli ale tesutului conjunctiv6;7.. Din punct de vedere histologic miozita poate fi diferenţiata in miozita interstitiala fara distructia fibrei musculare, miozita focala cu infiltrat inflamator si leziuni ale fibrei musculare si miozita difuza.. Polimiozita (PM) se caracterizează clinic prin febra, slabiciune musculara, artralgii, posibil sindrom Raynaud.. In dermatomiozita (DM) ...
http://lamedic.ro/profil-miozita-blot
Publications | bengt-hallberg-lab
Berry, T., Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE. The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma. Cancer Cell. 2012 Jul 10;22(1):117-30. ...
https://www.bengt-hallberg-lab.com/publications
New & Used Chrysler 200 for Sale in Crest Hill, IL
Find the perfect Chrysler 200 near Crest Hill, IL at a great price with Capital One Auto Navigator. Browse Chrysler 200 listings, prices & photos near Crest Hill, IL
https://www.capitalone.com/cars/find/60403/new-used/all-years/Chrysler/200/all-trims/all-bodystyles/any-price?page=1&radius=25
Wildwood Crest Real EstateWildwood Crest Real Estate
Search homes for sale in Wildwood Crest, NJ for free. View all 5 listings available in Wildwood Crest with an average price of $705,960. See Maps, Photos, and More.
https://www.sjcpropertysolutions.com/areas/Wildwood+Crest
CREST syndromeCREST syndrome
"CREST syndrome: MedlinePlus Medical Encyclopedia Image". medlineplus.gov. "CREST syndrome - Genetic and Rare Diseases ... CREST syndrome can be noted in up to 10% of patients with primary biliary cholangitis. The combination of symptoms was first ... CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue ... CREST syndrome is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually ...
https://en.wikipedia.org/wiki/CREST_syndrome
SclerodactylySclerodactyly
... is one component of the limited cutaneous form of systemic sclerosis (lcSSc), also known as CREST syndrome (CREST ... "CREST syndrome: MedlinePlus Medical Encyclopedia Image". medlineplus.gov. Retrieved 2022-08-12. Patrizi, A.; Di Lernia, V.; ... Sclerodactyly is also one component of Huriez Syndrome, along with palmoplantar keratoderma and skin cancer. Sclerodactyly ... Patrone, P. (May 1992). "Palmoplantar keratoderma with sclerodactyly (Huriez syndrome)". Journal of the American Academy of ...
https://en.wikipedia.org/wiki/Sclerodactyly
Raynaud syndromeRaynaud syndrome
This may be the case in the CREST syndrome, of which Raynaud's is a part.[citation needed] Patients with secondary Raynaud's ... Anti-centromere antibodies are common in limited systemic sclerosis (CREST syndrome). Nail fold vasculature (capillaroscopy) ... Mechanism of Raynaud's syndrome results in vasoconstriction of the blood vessels due to hyperactivation of sympathetic nervous ... Raynaud syndrome, also known as Raynaud's phenomenon, eponymously named after the physician Auguste Gabriel Maurice Raynaud, ...
https://en.wikipedia.org/wiki/Raynaud_syndrome
Anti-topoisomerase antibodiesAnti-topoisomerase antibodies
... but is also seen the more limited form of systemic scleroderma called CREST syndrome. However, CREST syndrome is more closely ...
https://en.wikipedia.org/wiki/Anti-topoisomerase_antibodies
Systemic sclerodermaSystemic scleroderma
Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasia (CREST syndrome) are associated ...
https://en.wikipedia.org/wiki/Systemic_scleroderma
JAG1JAG1
"Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients". Hum. Mol. ... GeneReviews/NCBI/UW/NIH entry on Alagille syndrome OMIM entries on Alagille syndrome JAG1+protein,+human at the US National ... McCright B, Lozier J, Gridley T (2002). "A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 ... Notch signaling Alagille syndrome Autosomal dominant Haploinsufficiency Tetralogy of fallot In situ hybridization Conditional ...
https://en.wikipedia.org/wiki/JAG1
Superior cluneal nervesSuperior cluneal nerves
Application to posterior iliac crest harvest and entrapment syndromes". Journal of Neurosurgery: Spine. 13 (3): 356-359. doi: ... After the iliac crest, the nerves terminate over the gluteal fascia. These nerves carry only sensory input and have no motor ... The nerves then go through an osteofibrous tunnel created by the thoracolumbar fascia and rim of the superior iliac crest. ... Direct injury to the cluneal never can happen during posterior iliac crest harvest to obtain bone mineral for other surgeries, ...
https://en.wikipedia.org/wiki/Superior_cluneal_nerves
Calcinosis cutisCalcinosis cutis
In addition, calcinosis is seen in Limited Cutaneous Systemic Sclerosis, also known as CREST syndrome (the "C" in CREST). In ... Calcinosis cutis in a dog with Cushing's syndrome Calcinosis cutis in human tissue Calcinosis List of cutaneous conditions ...
https://en.wikipedia.org/wiki/Calcinosis_cutis
ZNF74ZNF74
Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M (2000). "ZNF74, a gene deleted in DiGeorge syndrome, is expressed ... in human neural crest-derived tissues and foregut endoderm epithelia". Genomics. 62 (1): 82-5. doi:10.1006/geno.1999.5982. PMID ... "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome". Hum. Mol. Genet. 2 (10): 1583-7. doi:10.1093/hmg/ ...
https://en.wikipedia.org/wiki/ZNF74
Livedo reticularisLivedo reticularis
"Livedo Reticularis and Bowel Ischemia after Carbon Dioxide Arteriography in a Patient with CREST Syndrome". Journal of Vascular ... "Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ('FILS syndrome ... Kazmier F, Sheps S, Bernatz P, Sayre G (1966). "Livedo reticularis and digital infarcts: a syndrome due to cholesterol emboli ... Daneshpazhooh M, Nazemi TM, Bigdeloo L, Yoosefi M (2007). "Mucocutaneous findings in 100 children with Down syndrome". Pediatr ...
https://en.wikipedia.org/wiki/Livedo_reticularis
PACS1PACS1
... mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome". ... colloquially called PACS1 Syndrome) that is characterized by global developmental delay, intellectual disability, and specific ...
https://en.wikipedia.org/wiki/PACS1
Pulmonary capillary hemangiomatosisPulmonary capillary hemangiomatosis
Pulmonary veno-occlusive disease This condition has been reported in patients with Ehlers Danlos syndrome, CREST syndrome and ... Pulmonary capillary hemangiomatosis associated with CREST syndrome: A challenge of diagnosis and treatment. Chin Med J (Engl) ... Chest 151(4):821-828 Park MA, Shin SY, Kim YJ, Park MJ, Lee SH (2017) Vascular Ehlers-Danlos syndrome with cryptorchidism, ... Reactive pulmonary capillary hemangiomatosis and pulmonary veno-acclusive disease in a patient with repaired scimitar syndrome ...
https://en.wikipedia.org/wiki/Pulmonary_capillary_hemangiomatosis
Domestication of animalsDomestication of animals
Because the traits commonly affected by domestication syndrome are all derived from NCC in development, the neural crest ... The Neural Crest Hypothesis relates adrenal gland function to deficits in neural crest cells during development. The Single ... Domestication syndrome is a term often used to describe the suite of phenotypic traits arising during domestication that ... Neural crest cells (NCC) are vertebrate embryonic stem cells that function directly and indirectly during early embryogenesis ...
https://en.wikipedia.org/wiki/Domestication_of_animals
Betty Jane CornettBetty Jane Cornett
... retiring in 1987 after being diagnosed with CREST syndrome. After that, she was invited to several AAGPBL Players Association ...
https://en.wikipedia.org/wiki/Betty_Jane_Cornett
ABCD syndromeABCD syndrome
"Autosomal-recessive neural crest syndrome with albinism, black lock, cell migration disorder of the neurocytes of the gut, and ... This helped them distinguish forms of Waardenburg syndrome. Their evaluation consisted of specifying Waardenburg syndrome type ... Mallory, Susan B. (2006). "ABCD Syndrome". An Illustrated Dictionary of Dermatologic Syndromes (2nd ed.). Taylor & Francis. ... According to a dictionary of dermatologic syndromes, Waardenburg syndrome has many notable features, including "depigmentation ...
https://en.wikipedia.org/wiki/ABCD_syndrome
Prepatellar bursitisPrepatellar bursitis
CREST syndrome,: p. 359 diabetes mellitus, alcohol use disorder, uremia, and chronic obstructive pulmonary disease.: p. 22 Some ...
https://en.wikipedia.org/wiki/Prepatellar_bursitis
AlbinismAlbinism
... include neural crest disorders such as piebaldism, Waardenburg syndrome, or other depigmentation conditions such as vitiligo. ... are largely responsible for generating skin and eye colour in poikilothermic animals and are generated in the neural crest ...
https://en.wikipedia.org/wiki/Albinism
Anti-centromere antibodiesAnti-centromere antibodies
They occur in some autoimmune diseases, frequently in limited systemic scleroderma (formerly called CREST syndrome), and ...
https://en.wikipedia.org/wiki/Anti-centromere_antibodies
Waardenburg syndromeWaardenburg syndrome
The syndrome is caused by mutations in any of several genes that affect the division and migration of neural crest cells during ... Chédiak-Higashi syndrome, a similar syndrome including immunodeficiency and peripheral neuropathy Tietz syndrome, a condition ... Lethal white syndrome is a syndrome in horses caused by mutations in both copies of EDNRB. It leads to death from intestinal ... Also known as Shah-Waardenburg syndrome, or Waardenburg-Shah syndrome, type 4 has most of the same features as type 2 (i.e. no ...
https://en.wikipedia.org/wiki/Waardenburg_syndrome
DomesticationDomestication
... syndrome is the suite of phenotypic traits arising during domestication that distinguish crops from their wild ... docility in mammals and birds results partly from a slowed pace of neural crest development, that would in turn cause a reduced ... The theory was unable to explain curly tails nor domestication syndrome exhibited by plants. A side effect of domestication has ... Wilkins, Adam S.; Wrangham, Richard W.; Fitch, W. Tecumseh (July 2014). "The 'Domestication Syndrome' in Mammals: A Unified ...
https://en.wikipedia.org/wiki/Domestication
TelangiectasiaTelangiectasia
... are one of the features of the acronymically named CREST syndrome, a form of systemic scleroderma. The syndrome recognises the ... Osler-Weber-Rendu syndrome) Ataxia-telangiectasia Sturge-Weber syndrome, a nevus formation in the skin supplied by the ... Klippel-Trenaunay syndrome Maffucci syndrome (multiple enchondromas and hemangiomas) Hereditary hemorrhagic telangiectasia ( ... Tempi syndrome Tobacco smoking Cutaneous collagenous vasculopathy Before any treatment of leg telangectasia (spider veins) is ...
https://en.wikipedia.org/wiki/Telangiectasia
Esophageal motility disorderEsophageal motility disorder
... may be a result of CREST syndrome, referring to the five main features: calcinosis, Raynaud ... CREST syndrome, or achalasia). The most common form of dysphagia is achalasia, which is caused by degeneration of the nerves in ... a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins Hospital 114: 31-83. PMID 14171636. ... syndrome, esophageal dysmotility, sclerodactyly and telangiectasia. Symptoms of EMD can include chest pain, and intermittent ...
https://en.wikipedia.org/wiki/Esophageal_motility_disorder
Antinuclear antibodyAntinuclear antibody
Anti-centromere antibodies are associated with limited cutaneous systemic sclerosis, also known as CREST syndrome, primary ... In Sjögren's syndrome, anti-Ro and anti-La antibodies correlate with early onset, increased disease duration, parotid gland ... The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of ... Anti-La antibodies are also found in SLE; however, Sjögren's syndrome is normally also present. Anti-Ro antibodies are also ...
https://en.wikipedia.org/wiki/Antinuclear_antibody
SclerodermaScleroderma
One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal ... causing a limited systemic form and the CREST syndrome). Other autoantibodies can be seen, such as anti-U3 or anti-RNA ... Eosinophilia-myalgia syndrome is a form of eosinophilia caused by L-tryptophan supplements. Eosinophilic fasciitis affects the ... Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma Systemic scleroderma CREST syndrome ...
https://en.wikipedia.org/wiki/Scleroderma
EsophagusEsophagus
Sclerosis of the esophagus, such as with systemic sclerosis or in CREST syndrome may cause hardening of the walls of the ... Half of these cases may be part of a syndrome where other abnormalities are also present, particularly of the heart or limbs. ... Strictures may also develop in chronic anemia, and Plummer-Vinson syndrome. Two of the most common congenital malformations ...
https://en.wikipedia.org/wiki/Esophagus
Index of oral health and dental articlesIndex of oral health and dental articles
Crest • Crossbite • Crouzon syndrome • Crown-to-root ratio • Crown • Crown • Crown lengthening • Crunchiness • Curve of spee • ... Frey's syndrome • Fungiform papilla • G. Walter Dittmar • Gardner's syndrome • Gargling • Gaspard Fauteux • Gene Derricotte • ... Tariq Faraj • E. Lloyd Du Brul • Eagle syndrome • Early childhood caries • Eastman Kodak • Ed Lafitte • Eco-friendly dentistry ... Peutz-Jeghers syndrome • Piercing • Phil Samis • Philip A. Traynor • Philip Blaiberg • Philtrum • Pierre Corbeil • Pierre ...
https://en.wikipedia.org/wiki/Index_of_oral_health_and_dental_articles
List of diseases (C)List of diseases (C)
... see also CREST syndrome) Calciphylaxis Calculi Calderon-Gonzalez-Cantu syndrome Calloso genital dysplasia Callus disease ... CCA syndrome Ccge syndrome CCHS CDG syndrome CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 ... syndrome Coffin-Siris syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Gibson syndrome Cohen-Hayden syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome Codas syndrome Codesette syndrome Coeliac ...
https://en.wikipedia.org/wiki/List_of_diseases_(C)
Anti-Scl-70 antibodiesAnti-Scl-70 antibodies
... of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with ...
https://en.wikipedia.org/wiki/Anti-Scl-70_antibodies
List of skin conditionsList of skin conditions
Calcinosis-Raynaud phenomenon-esophageal dysmotility-sclerodactyly-telangiectasia syndrome (CREST syndrome) Chilblain lupus ... Turner syndrome Ulnar-mammary syndrome Van Der Woude syndrome Von Hippel-Lindau syndrome Watson syndrome Werner syndrome (adult ... Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome) Wilson-Turner syndrome Wolf-Hirschhorn syndrome (4p- syndrome) X-linked ... Rombo syndrome Rothmund-Thomson syndrome (poikiloderma congenitale) Rud syndrome Say syndrome Scalp-ear-nipple syndrome (Finlay ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
List of MeSH codes (C06)List of MeSH codes (C06)
... crest syndrome MeSH C06.405.117.119.500.432 - esophageal achalasia MeSH C06.405.117.119.500.450 - esophageal spasm, diffuse ... gardner syndrome MeSH C06.405.469.578.750 - peutz-jeghers syndrome MeSH C06.405.469.600 - jejunal diseases MeSH C06.405.469.600 ... zollinger-ellison syndrome MeSH C06.552.150.125 - alagille syndrome MeSH C06.552.150.250 - liver cirrhosis, biliary MeSH ... postgastrectomy syndromes MeSH C06.405.748.630.310 - dumping syndrome MeSH C06.405.748.789 - stomach neoplasms MeSH C06.405. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C06)
Deaths in December 2014Deaths in December 2014
Guillain-Barré syndrome. Peter Furneaux, 79, English football club chairman and investor (Grimsby Town). Andre Gill, 73, ... Falcon Crest) and television personality, Miss America (1959), breast cancer. Lydia Mordkovitch, 70, Russian-born British ...
https://en.wikipedia.org/wiki/Deaths_in_December_2014
Spinal cordSpinal cord
Brown-Séquard syndrome Hereditary spastic paraplegia (HSP, or familial spastic paraplegia - FSP, Strümpell-Lorrain syndrome) ... Dorsal root ganglion neurons differentiate from neural crest progenitors. As the dorsal and ventral column cells proliferate, ... Post-polio syndrome Redlich-Obersteiner's zone Subacute combined degeneration of spinal cord Tethered spinal cord syndrome ...
https://en.wikipedia.org/wiki/Spinal_cord
Brian AldissBrian Aldiss
Fawcett Crest), (1975, Pan) A 21st century politician is transported to 19th century Switzerland where he encounters Victor ... "Randy's Syndrome" (novelette), "Send Her Victorious or the War Against the Victorians, 2000 A.D." (novelette), "Intangibles, ... ", "Randy's Syndrome" (novelette), "Still Trajectories", "Two Modern Myths: Reflection on Mars and Ultimate Construction", " ...
https://en.wikipedia.org/wiki/Brian_Aldiss
Japanese Canadians in British ColumbiaJapanese Canadians in British Columbia
Audrey Kobayashi, social scientist Santa J. Ono, biologist Irene Uchida, scientist and Down syndrome researcher Tomekichi Homma ... Falcon Crest Hiro Kanagawa, actor, Smallville, The Man in the High Castle Byron Lawson, actor, Snakes on a Plane Margaret Lyons ...
https://en.wikipedia.org/wiki/Japanese_Canadians_in_British_Columbia
GLI2GLI2
Mutations of the GLI2 gene are associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister- ... migration and differentiation of the neural crest. In this context, Gli2 is responding to the Indian Hedgehog signaling pathway ... Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. In human keratinocytes Gli2 activation ... "Gli2 is required for the induction and migration of Xenopus laevis neural crest". Mechanisms of Development. 154: 219-239. doi: ...
https://en.wikipedia.org/wiki/GLI2
List of automobiles known for negative receptionList of automobiles known for negative reception
It was voted the ugliest car in the UK in 2005, with an article on Jalopnik calling it an "R-Class with Down's Syndrome". Top ... "Despite an ad campaign that featured both Cindy Crawford and animated versions of the ducks found on the Cadillac crest, there ...
https://en.wikipedia.org/wiki/List_of_automobiles_known_for_negative_reception
2013 horse meat scandal2013 horse meat scandal
Some news outlets referred to EIA as "Horse AIDS", even though it is not an immunodeficiency syndrome and the retrovirus that ... Ireland and Dairy Crest, Rossington. Hamburger meat from Silvercrest Foods, a subsidiary of Larry Goodman's ABP Food Group, in ...
https://en.wikipedia.org/wiki/2013_horse_meat_scandal
BAZ1BBAZ1B
... has been found to affect the activity of 448 other genes and is very important in the development of the neural crest and ... Lu X, Meng X, Morris CA, Keating MT (December 1998). "A novel human gene, WSTF, is deleted in Williams syndrome". Genomics. 54 ... This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. ... December 2004). "The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to ...
https://en.wikipedia.org/wiki/BAZ1B
Mediator (coactivator)Mediator (coactivator)
... and are prevented by mutations in MED12 that produce the human disease FG syndrome. Thus, the structure of a mediator complex ... "Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency". Hum ...
https://en.wikipedia.org/wiki/Mediator_(coactivator)
List of Ultraman Max charactersList of Ultraman Max characters
His other weapons include: Maxium Sword (マクシウムソード, Makushiumu Sōdo): A space boomerang that stored on his head crest, which he ... causing them to become extremely energetic but later on subjugate them to burnout syndrome. Professor Yoshinaga invented its ...
https://en.wikipedia.org/wiki/List_of_Ultraman_Max_characters
Battle of StrasbourgBattle of Strasbourg
The German host was waiting for the Romans, probably drawn up on the crest of the hill, to give Chnodomar's men the advantage ... "Alexander the Great syndrome": the desire to emulate the Macedonian general and conquer the Persian empire. He invaded ...
https://en.wikipedia.org/wiki/Battle_of_Strasbourg
EGR2EGR2
... and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived ... "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype". Neurology. 52 ... conserved and divergent patterns of expression in rhombomeres and neural crest". Mechanisms of Development. 40 (1-2): 73-84. ...
https://en.wikipedia.org/wiki/EGR2
OryzomysOryzomys
On both the second and third lower molars, the anterolophid (a crest on the inner front corner) is present, a putative ... The marsh rice rat is the natural reservoir of the Bayou virus, the second most common cause of hantavirus pulmonary syndrome ... Behind the anterocone, the anteroloph (a smaller crest) is complete and separated from the anterocone. ... a crest at the front of the tooth). The hypothenar pad of the hindfoot, located on the sole far from the fingers, is present in ...
https://en.wikipedia.org/wiki/Oryzomys
Sacroiliac joint dysfunctionSacroiliac joint dysfunction
Pressure is applied downward to the uppermost iliac crest. FABER or Patrick test - To identify if pain may come from the ... The biomechanical relationship between the sacroiliac joint, the piriformis muscle (see "piriformis syndrome"), and the sciatic ... "iliotibial band syndrome") and hip flexors, including the psoas muscle. Individuals with severe and long-standing sacroiliac ... Postnatal Pelvic Joint Syndrome and Developmental Dysplasia of Hip". Acta Obstet Gynecol Scand. 76 (8): 760-764. doi:10.3109/ ...
https://en.wikipedia.org/wiki/Sacroiliac_joint_dysfunction
PAX3PAX3
Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA (June 2008). "Persistent expression of Pax3 in the neural crest ... Baldwin CT, Hoth CF, Macina RA, Milunsky A (August 1995). "Mutations in PAX3 that cause Waardenburg syndrome type I: ten new ... Pax3 is later expressed by various cell types and structures arising from the neural crest, such as melanoblasts, Schwann cell ... In addition, Pax3-expressing cells derived from the neural crest contribute to the formation of other structures, such as the ...
https://en.wikipedia.org/wiki/PAX3
Sabino horseSabino horse
Neither Sabino 1 or any other alleles of W are linked to lethal white syndrome (LWS). LWS occurs when a foal is homozygous for ... KIT plays an important role in the migration of early pigment cells (melanocytes) from the neural crest to their ultimate ... Vrotsos, PD; Santschi EM; Mickelson JR (2001). "The Impact of the Mutation Causing Overo Lethal White Syndrome on White ... "A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: an equine version of ...
https://en.wikipedia.org/wiki/Sabino_horse
Wildwood Crest, New JerseyWildwood Crest, New Jersey
... has eluded much of the tear-down syndrome." Hutchinson, Viola L. The Origin of New Jersey Place Names, New Jersey Public ... Wildwood Crest homepage Crest Memorial School School Performance Reports for the Crest Memorial School, New Jersey Department ... Crest Fishing Pier Sunset Lake According to the Köppen climate classification system, Wildwood Crest, New Jersey has a humid ... Composition: The Wildwood Crest School District is comprised of all the area within the municipal boundaries of Wildwood Crest ...
https://en.wikipedia.org/wiki/Wildwood_Crest,_New_Jersey
Congenital heart defectCongenital heart defect
... including Noonan syndrome, LEOPARD syndrome, Costello syndrome and cardiofaciocutaneous syndrome in which there is cardiac ... After this happens, cells that have migrated from the neural crest begin to divide the bulbus cordis, the main outflow tract is ... A number of genetic conditions are associated with heart defects, including Down syndrome, Turner syndrome, and Marfan syndrome ... Ebstein's anomaly Early Repolarization Syndrome Hypoplastic left heart syndrome (HLHS) Hypoplastic right heart syndrome (HRHS) ...
https://en.wikipedia.org/wiki/Congenital_heart_defect
VulpesVulpes
Sagittal crest not developed at all or weakly defined. Vulpes species have vertically-slit pupils, which generally appear ... "The History of Farm Foxes Undermines the Animal Domestication Syndrome". Trends in Ecology & Evolution. 35 (2): 125-136. doi: ...
https://en.wikipedia.org/wiki/Vulpes
Medial knee injuriesMedial knee injuries
Pellegrini-Stieda syndrome can also be seen on AP radiographs. This finding is due to calcification of the sMCL (heterotopic ... The other tibial section attaches directly to the tibia, anterior to the posteromedial tibial crest, 6 cm distal to the joint ... Pellegrini-Stieda syndrome". N Engl J Med. 354 (1): e1. doi:10.1056/nejmicm040406. PMID 16394294. Milewski MD, Sanders TG, ... Rixe, JA; Glick, JE; Brady, J; Olympia, RP (Sep 2013). "A review of the management of patellofemoral pain syndrome". The ...
https://en.wikipedia.org/wiki/Medial_knee_injuries
Ventricular outflow tractVentricular outflow tract
In the right ventricle, the inflow and outflow is separated by the supraventricular crest. In the left ventricle, the anterior ... Syndrome v t e (Articles needing cleanup from August 2022, Articles with bare URLs for citations from August 2022, All articles ... The RVOT is pathophysiologically affected in Brugada syndrome. Velocity time integral Gray's anatomy for students, 2nd edition ...
https://en.wikipedia.org/wiki/Ventricular_outflow_tract
SOX10SOX10
... and PAX3 interactions are thought to be regulators of other genes involved in the symptoms of Waardenburg syndrome, ... Southard-Smith EM, Kos L, Pavan WJ (1998). "Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model". ... This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system ... Mutations in this gene are associated with Waardenburg-Shah syndrome and uveal melanoma. SOX10 is used as an ...
https://en.wikipedia.org/wiki/SOX10
Development of the endocrine systemDevelopment of the endocrine system
At seven weeks of gestation, the adrenal cells are joined by sympathetic cells that originate from the neural crest to form the ... Mutations in TBX1 and CRKL genes are correlated with DiGeorge syndrome, while mutations in GATA3 have also resulted in a ... 1 April 2001). "The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and ... respiratory distress syndrome, jaundice, cardiomyopathy, congenital heart disease, and improper organ development. The ...
https://en.wikipedia.org/wiki/Development_of_the_endocrine_system
Music of SeattleMusic of Seattle
"Seattle Syndrome" compilation, released in late 1981 on Engram Records and regarded by music historian Stephen Tow as "a ... The Wailers first album came out on Golden Crest Records; subsequent releases came out on Etiquette, the first record label ...
https://en.wikipedia.org/wiki/Music_of_Seattle
T-cadherinT-cadherin
... is a cytokine produced by adipose tissue and its deficiency is associated with metabolic syndrome, obesity, type II diabetes ... as a negative guiding cue for motor axon projecting through the somitic sclerotome and presumably for migrating neural crest ...
https://en.wikipedia.org/wiki/T-cadherin
CREST Syndrome: Background, Pathophysiology, EtiologyCREST Syndrome: Background, Pathophysiology, Etiology
In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calc... ... syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features ... CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) ... encoded search term (CREST Syndrome) and CREST Syndrome What to Read Next on Medscape ...
https://www.medscape.com/answers/1064663-76369/what-is-the-historical-background-of-crest-syndrome
CREST syndrome: MedlinePlus Medical Encyclopedia ImageCREST syndrome: MedlinePlus Medical Encyclopedia Image
CREST is an acronym for the clinical features that are seen in a patient ... The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis, scleroderma ... Usually only 2 of the 5 symptoms of the CREST syndrome is necessary to be diagnosed with the disease. ... The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis (scleroderma ...
https://medlineplus.gov/ency/imagepages/19507.htm
CREST Syndrome Differential DiagnosesCREST Syndrome Differential Diagnoses
In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calc... ... syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features ... CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) ... encoded search term (CREST Syndrome) and CREST Syndrome What to Read Next on Medscape ...
https://emedicine.medscape.com/article/1064663-differential
CREST Syndrome: Background, Pathophysiology, EtiologyCREST Syndrome: Background, Pathophysiology, Etiology
In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calc... ... syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features ... CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) ... encoded search term (CREST Syndrome) and CREST Syndrome What to Read Next on Medscape ...
https://emedicine.staging.medscape.com/article/1064663-overview
CREST syndrome | Gamuts.netCREST syndrome | Gamuts.net
CREST syndrome. CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem ... CREST syndrome Is A. Connective tissue disease. Scleroderma. May Cause. Abnormal odontoid process. Achalasia. Atlantoaxial ... and telangiectasia.CREST syndrome is associated with detectable antibodies against centromeres (a component of the cell nucleus ... The acronym "CREST" refers to the five main features: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, ...
http://www.gamuts.net/display.php?id=9735
Crest syndrome. Medical search. Website summariesCrest syndrome. Medical search. Website summaries
CREST syndrome A less severe form of scleroderma is called CREST.. The CREST syndrome represents symptoms including calcium ... CREST syndrome - Wikipedia. CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a ... Crest Syndrome Thrombocytopenia. Tips to help with your thrombocytopenia: Crest Syndrome Thrombocytopenia. My thrombocytopenia ... Crest Syndrome Symptoms, Diagnosis & Treatment Options , MedicalAdvicePlus.com. Crest syndrome is an acronym for Calcinosis; ...
https://lookformedical.com/en/sites/crest-syndrome
Doxy 1 Price, Plaquenil For Crest Syndrome - Sexsmith Self StorageDoxy 1 Price, Plaquenil For Crest Syndrome - Sexsmith Self Storage
The plaquenil for crest syndrome drug was developed primarily to treat male pattern hair loss. The most common side effect was ... If you want the sex she craves, then there are three things plaquenil for crest syndrome that you can do to make her the best ... Plaquenil for crest syndrome, cost of flonase at cvs. 2022-6-3. by sexsmithselfstorage ... The number of people who died of an overdose increased by 2,200 plaquenil for crest syndrome or by 4 percent since 2016, with ...
https://sexsmithselfstorage.com/52256-plaquenil-for-crest-syndrome-26246/
Scleroderma | Boston Childrens HospitalScleroderma | Boston Children's Hospital
CREST syndrome. A less severe form of scleroderma is called CREST. The CREST syndrome represents the following symptoms:. * ...
https://www.childrenshospital.org/conditions/scleroderma
Systemic Sclerosis Imaging: Practice Essentials, Radiography, Computed TomographySystemic Sclerosis Imaging: Practice Essentials, Radiography, Computed Tomography
Overlap syndromes or CREST syndrome are suggested when pulmonary hypertension is out of proportion to the degree of fibrosis. ... scleroderma overlap the following syndromes [14] :. * CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, ... The stiff skin syndrome: case series, differential diagnosis of the stiff skin phenotype, and review of the literature. Arch ...
https://emedicine.medscape.com/article/362660-overview
Acta Médica Grupo Angeles - 2019 - 3
Severe calcinosis in hands as part of CREST syndrome Dom nguez Carrillo, Luis Gerardo; Arellano Aguilar, Gregorio ... Neuroleptic malignant syndrome Ortega Chavarr a, Mar a Jos ; D az Greene, Enrique; Rodr guez Weber, Federico. ... Horner s syndrome after cervical spine surgery: an uncommon association Dom nguez Carrillo, Luis Gerardo; Alcocer Maldonado, ... Fragile X syndrome Navarro Vidaurri, Germ n; Dom nguez Carrillo, Luis Gerardo. ...
https://www.medigraphic.com/cgi-bin/new/contenidoI.cgi?IDPUBLICACION=8467
MESH TREE NUMBER CHANGES - 2008 MeSHMESH TREE NUMBER CHANGES - 2008 MeSH
CREST Syndrome C14.907.744.500 C14.907.617.812.500. Cryoglobulinemia C14.907.934.140 C14.907.454.140. Curare D3.132.436.255. ... Shy-Drager Syndrome C14.907.514.482.853 C14.907.514.741. Sick Sinus Syndrome C14.280.67.829 C14.280.67.93.249. C14.280.67.558. ... Sturge-Weber Syndrome C4.700.852. C16.320.700.852. Subclavian Steal Syndrome C14.907.253.92.956.700. Substantia Innominata ... Williams Syndrome C14.280.484.150.60.960 C14.280.484.150.535.960. Wolff-Parkinson-White Syndrome C16.131.240.400.980. Wolffian ...
https://decs.bvs.br/P/mnchg2008.htm
Pulmonary Hypertension Causes and Diagnoses | Northwestern MedicinePulmonary Hypertension Causes and Diagnoses | Northwestern Medicine
CREST syndrome and scleroderma. *Systemic lupus erythematosus. *Sjögrens syndrome. *Dermatomyositis. *Polymyositis. * ...
https://www.nm.org/conditions-and-care-areas/cardiovascular-care/center-for-heart-failure/pulmonary-hypertension/causes-and-diagnoses
Faculty of Medicine and Health Sciences - Research output - University of East AngliaFaculty of Medicine and Health Sciences - Research output - University of East Anglia
Watermelon stomach in the CREST Syndrome. Beales, I., 1994, In: Postgraduate Medical Journal.. Research output: Contribution to ...
https://research-portal.uea.ac.uk/en/organisations/faculty-of-medicine-and-health-sciences/publications/?page=366
Denture Cream Class Action Lawsuits Filed Over Fixodent and Poligrip - AboutLawsuits.comDenture Cream Class Action Lawsuits Filed Over Fixodent and Poligrip - AboutLawsuits.com
In 1995 I was diagnosed with CREST SYNDROME. One of the causes of CREST can be silica ( a toxin ) which is used in denture ... In 1995 I was diagnosed with CREST SYNDROME. One of the causes of CREST can be silica ( a toxin ) which is used in denture ... I began to experience RLS (Restless Leg Syndrome) a[Show More]Have used Super Poligrip & Fixodent for about 3 years to hold in ... In 2006 I had Thoracic Outlet Syndrome, which I had surgery for. In 2008 I developed Bells Palsy. I have had a constant pain, ...
https://www.aboutlawsuits.com/denture-cream-class-action-lawsuits-over-fixodent-poligrip-3422/
Welcome to PhenoDisWelcome to PhenoDis
CREST Syndrome Winterbauer (1964) defined and named the CRST syndrome (calcinosis, Raynaud syndrome, sclerodactyly, ... 1977) described the CRST syndrome in mother and daughter. McColl and Buchanan (1994) described the CREST syndrome in 2 sisters ... The CRST syndrome simulates hereditary telangiectasia; see 187300.) The initialism CRST was expanded to the acronym CREST by ... See also Reynolds syndrome (613471), which shares some clinical features with scleroderma and CREST syndrome. ...
http://mips.helmholtz-muenchen.de/phenodis/disease/show/7081
Primary Biliary Cirrhosis Treatment: Management of Itching, Surgery, Drugs & Side EffectsPrimary Biliary Cirrhosis Treatment: Management of Itching, Surgery, Drugs & Side Effects
It is recommended that patients with these symptoms or other evidence of scleroderma or the CREST syndrome:. *Take drugs called ... and even more rarely the hepatopulmonary syndrome (breathing difficulty in advanced cirrhosis). The regional review committees ...
https://www.rxlist.com/primary_biliary_cirrhosis_treatment_pbc/article.htm
Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease...Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease...
... mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome. ... Similarly, highly penetrant syndromic CNVs such as Smith-Magenis syndrome and Sotos syndrome, which are mostly de novo and ... Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes *Weicheng ... Histone modifier genes alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. Am J Hum Genet. 2015;97:869-877. ...
https://www.nature.com/articles/s41436-018-0266-3?error=cookies_not_supported&code=27217e55-feb3-4664-9284-f5612d0b74df
Overstride-Induced Medial Knee Desmopathy: An Exploration Case Series | Journal of Athletic TrainingOverstride-Induced Medial Knee Desmopathy: An Exploration Case Series | Journal of Athletic Training
Similarly, Klontzas et al5 identified a medial tibial crest friction syndrome; standard anteroposterior and lateral tibia- ... or the inferior angle of the tibial crest reasonably eliminates either pes anserine bursitis or tibial crest friction syndrome ... friction syndromes (posteromedial and medial tibial crest), and bone tumors. Depending on the age of the patient, apophysitis ... Posteromedial knee friction syndrome: an entity with medial knee pain and edema between the femoral condyle, sartorius and ...
https://meridian.allenpress.com/jat/article/55/12/1255/447917/Overstride-Induced-Medial-Knee-Desmopathy-An
med surg II Unit 1 Flashcardsmed surg II Unit 1 Flashcards
There are two main types of systemic scleroderma: Limited disease (CREST syndrome) and diffuse disease.. ...
https://www.flashcardmachine.com/med-surg-iiunit1.html
Table of contents | GutTable of contents | Gut
CREST syndrome and primary biliary cirrhosis: an overlap syndrome? (1 October, 1989) Free R F McMahon, C Babbs, T W Warnes ...
https://gut.bmj.com/content/30/10
Heartburn (GERD): Facts, Treatment, Causes, Symptoms & PreventionHeartburn (GERD): Facts, Treatment, Causes, Symptoms & Prevention
A hiatal hernia, diabetes, and many autoimmune diseases (CREST syndrome, Raynauds phenomenon, and scleroderma) are linked to ...
https://www.emedicinehealth.com/heartburn_faqs/article_em.htm
Understanding Scleroderma | HSS Scleroderma CenterUnderstanding Scleroderma | HSS Scleroderma Center
Limited scleroderma is also sometimes called CREST syndrome, which is an acronym of its common features:. *calcinosis: nodules ... also known as CREST syndrome) and diffuse scleroderma. (Find a systemic scleroderma specialist at HSS.) ...
https://www.hss.edu/condition-list_scleroderma.asp
krt12.4 Literature [Xenopus] - Xenbase Gene Catalog krt12.4 Literature [Xenopus] - Xenbase Gene Catalog
mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration., Schwenty-Lara J, Nehl D, ... Molecular mechanisms of hearing loss in Nager syndrome., Maharana SK, Saint-Jeannet JP., Dev Biol. August 1, 2021; 476 200-208. ... defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates., Plouhinec JL, Medina-Ruiz S, Borday C ... depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome., Devotta A, Juraver- ...
https://www.xenbase.org/entry/gene/attribution.do?objId=6539689&objId2=DOID&att=krt12.4&att2=Disease+Ontology&action=VIEW&objName=FEATURE&objName2=DBXREF&objNameSrt=FEAT&attPage=PAPER&litOnly=1&tabId=2
Frontiers | Did Dog Domestication Contribute to Language Evolution?Frontiers | Did Dog Domestication Contribute to Language Evolution?
... "domestication syndrome" (Wilkins et al., 2014). Although it is disputed that this syndrome is a universal outcome of all ... Sánchez-Villagra, M. R., Geiger, M., and Schneider, R. A. (2016). The taming of the neural crest: a developmental perspective ... Pober, B. R. (2003). "Williams syndrome," in NORD Guide to Rare Disorders, eds B. A. Kozel, S. J. Bayliss, D. R. Berk, J. L. ... Morris, C. A. (2010). Introduction: williams syndrome. Am. J. Med. Genet. C Semin. Med. Genet. 154C, 203-208. doi: 10.1002/ajmg ...
https://www.frontiersin.org/articles/10.3389/fpsyg.2021.695116/full
Hirschsprung Disease: Background, Pathophysiology, EpidemiologyHirschsprung Disease: Background, Pathophysiology, Epidemiology
Neurocristopathy syndromes: Neurocristopathies represent a broad range of disorders characterized by aberrant neural crest ... 23] It may be associated with the following syndromes:. * Down syndrome: Trisomy 21 is characterized by physical growth delays ... Yemenite deaf-blind syndrome: Affected patients have a mutation in the SRY-related HMG-box gene. The syndrome is characterized ... Waardenburg-Shah syndrome: Patients have a sensorineural hearing deficit and hypopigmentation of the iris and hair. ...
https://reference.medscape.com/article/178493-overview
Burning Mouth Syndrome Causes, Symptoms & Treatments | Dentalcare
Understand what is burning mouth syndrome causes, symptoms and treatment at Dentalcare. ... Burning mouth syndrome affects up to 15% of older patients. ... Join Our Crest + Oral-B Professional Community. Login or ... Burning mouth syndrome treatment and remedies. The first step in burning mouth syndrome treatment is to remove any local ... This is classified as Burning Mouth Syndrome.. Burning mouth syndrome causes. Despite there being no visible evidence of the ...
https://www.dentalcare.com/en-us/patient-education/english-articles/burning-mouth-syndrome
Norman Kent Productions | Norman - Norman Kent Productions
In the midst of filming "Willing to Fly", Deanna became ill with a little known disease called CREST syndrome. Norman and ...
https://www.normankent.com/norman
CRSToday | How to Present Refractive Lens Exchange to PatientsCRSToday | How to Present Refractive Lens Exchange to Patients
Take the challenge out of discussing dysfunctional lens syndrome. ... Diagnosis and treatment of dysfunctional lens syndrome. CRST. ... Complete a 3-minute survey to help CRST understand your practice patterns during the COVID-19 pandemic and be entered for the ... The concept of dysfunctional lens syndrome (DLS), the use of advanced diagnostics to aid in its detection, and proper staging ... Use of dysfunctional lens syndrome grading to guide decision making in the surgical correction of presbyopia. Paper presented ...
https://crstoday.com/articles/2016-jul/how-to-present-refractive-lens-exchange-to-patients/?single=true
Dermatologic Manifestations of Waardenburg Syndrome: Practice Essentials, Pathophysiology, EpidemiologyDermatologic Manifestations of Waardenburg Syndrome: Practice Essentials, Pathophysiology, Epidemiology
Waardenburg syndrome is a rare disease characterized by deafness in association with pigmentary anomalies and defects of neural ... crest-derived tissues. Hammerschlag, in 1907, and Urbantschitsch, in 1910, both mentioned heterochromia iridium and partial ... The deficient neural crest theory, suggesting a developmental abnormality of the neural crest as a cause of the disease: The ... Waardenburg syndrome with familial unilateral renal agenesis: a new syndrome variant?. Ther Apher Dial. 2015 Jun. 19(3):296-8. ...
http://emedicine.medscape.com/article/1113314-overview
drugs in I.L.D. in sclerderma • Johns Hopkins Arthritis Centerdrugs in I.L.D. in sclerderma • Johns Hopkins Arthritis Center
She is also a follow through case of CREST syndrome. For past 2 years she is having dyspnea on exertion and cough. She was ...
https://www.hopkinsarthritis.org/ask-the-expert/drugs-in-i-l-d-in-sclerderma/
SclerodermaRaynaudRaynaud'sAcronymEsophagealMetabolicIliac crestLcSScSymptomsAutoimmuneAbnormalitiesCutaneousNeural crest developmentTissuesEmbryonicDisordersDysfunction1980MigrateWaardenburg SyndromeManifestationsCongenitalOverlapPrevalenceMigrationDevelopmentalDiseaseAnomaliesDefectsAnomalyPatientsSynonyms2016
Scleroderma11
  • Because it was designed for research applications and not for clinical diagnosis, it has been criticized for its low sensitivity in identifying early disease and milder forms of systemic scleroderma such as CREST syndrome. (medscape.com)
  • Several authors recognized this limitation and responded by categorizing patients with scleroderma syndromes into 2 groups: those with diffuse cutaneous scleroderma and those with a limited form of scleroderma. (medscape.com)
  • The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis (scleroderma). (medlineplus.gov)
  • Calcinosis in scleroderma: A reevaluation of the CRST syndrome, abstracted. (medscape.com)
  • The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.CREST syndrome is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). (gamuts.net)
  • In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. (lookformedical.com)
  • A less severe form of scleroderma is called CREST. (childrenshospital.org)
  • A hiatal hernia , diabetes , and many autoimmune diseases (CREST syndrome, Raynaud's phenomenon, and scleroderma ) are linked to heartburn. (emedicinehealth.com)
  • Within systemic scleroderma (also called systemic sclerosis), two major forms are recognized: limited scleroderma (also known as CREST syndrome) and diffuse scleroderma. (hss.edu)
  • CREST syndrome is a type of scleroderma. (healthclips.com)
  • The Drag Race contestant had been diagnosed with scleroderma, also called crest syndrome, back in 2018. (kingofreads.com)
Raynaud5
  • CREST ( calcinosis , Raynaud phenomenon , esophageal dysmotility , sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas , and its name is an acronym for the cardinal clinical features of the syndrome. (medscape.com)
  • In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST (calcinosis cutis, Raynaud phenomenon, sclerodactyly, and telangiectasia) syndrome in English by Winterbauer who, in 1964, described a series of 8 patients with the features that make up the abbreviation CRST. (medscape.com)
  • We report a case of 62-year-old Tunisian woman with a 10-year history of a CREST syndrome (systemic sclerosis meeting the criteria of the CREST syndrome of the 1980 American College of Rheumatology classification for raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). (lookformedical.com)
  • Patients with CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome ( C ) usually have anticentromere antibodies. (consultant360.com)
  • The pathophysiology of Raynaud syndrome is unknown. (medscape.com)
Raynaud's1
  • Multiple telangiectasia, Raynaud's phenomenon, sclerodactyly, and subcutaneous calcinosis: A syndrome mimicking hereditary hemorrhagic telangiectasia. (medscape.com)
Acronym2
  • [ 5 ] noted the frequent occurrence of esophageal dysmotility and suggested that the acronym CREST may be more appropriate. (medscape.com)
  • CREST is an acronym for the clinical features that are seen in a patient with this disease. (medlineplus.gov)
Esophageal2
  • [ 3 , 4 ] Although he noted esophageal dysmotility in 4 of 8 patients, he did not include this feature in his original description of CRST syndrome. (medscape.com)
  • When the defect in esophageal function is not prominent, it is known as CRST syndrome. (bvsalud.org)
Metabolic13
  • Accessible Version: www.cdc.gov/pcd/issues/2022/21_0231.htm to estimate the effect of anthropometric risk factors on the preval- ence of metabolic syndrome. (cdc.gov)
  • Risk Factors and Metabolic Syndrome Among Adults in India: A We searched databases PubMed Central, EMBASE, MEDLINE, Systematic Review and Meta-Analysis of Observational Studies. (cdc.gov)
  • Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)
  • Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)
  • However, no systematic effort has lipoprotein cholesterol [HDL-C], elevated triglycerides, and apoli- explored the effect of overweight and obesity on the prevalence of poprotein B-containing lipoproteins), elevated blood pressure, el- metabolic syndrome in India. (cdc.gov)
  • Metabolic syndrome recently emerged as a significant anthropometric factors and metabolic syndrome. (cdc.gov)
  • Hence, we under- and growing public health challenge worldwide resulting from took our meta-analysis to estimate the effect of anthropometric rapid urbanization, excessive energy intake, developing obesity, risk factors on the prevalence of metabolic syndrome to inform re- and sedentary lifestyle habits (2). (cdc.gov)
  • ABSTRACT This study assessed the prevalence of the metabolic syndrome, and its components, as defined by Adult Treatment Panel III criteria in Jordanian patients attending a family practice clinic for management of cardiovascular risk factors. (who.int)
  • Family practitioners should be alerted to the importance of multiple risk factors in the metabolic syndrome. (who.int)
  • The lifestyle of quilombola communities has changed due to extra community influence, thus affecting their environmental and behavioral factors related to the Metabolic Syndrome (MS). However, little is known about the influence of MS on the Quality of Life (QoL) of quilombola residents. (bvsalud.org)
  • It worsens in the presence of the metabolic syndrome (MetS), a complex disorder characterized by co-occurrence of at least three of such factors as hypertension, obesity, dyslipidemia and insulin resistance. (biomedcentral.com)
  • Similarly, NC can accurately predict metabolic syndrome syndrome conditions. (who.int)
  • Therefore, the limitations of BMI in metabolic syndrome, muscle-skeletal disorders, asthma detecting fat distribution and differentiating between fat and apnoea ( 2 ). (who.int)
Iliac crest2
  • A) A 1 .3 × 1.6 cm eschar with an erythematous halo is present at the site of a tick bite above the left iliac crest. (cdc.gov)
  • Changes in aerobic capacity assessed using 2-minute step test (the number of times the right knee reaching the point of midway between the patella and iliac crest within 2 minutes)[Baseline. (who.int)
LcSSc2
  • CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. (gamuts.net)
  • Raynauds phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. (lookformedical.com)
Symptoms3
  • Usually only 2 of the 5 symptoms of the CREST syndrome is necessary to be diagnosed with the disease. (medlineplus.gov)
  • Depending on your symptoms, some antidepressants that are used to treat anxiety may also be considered as a burning mouth syndrome treatment, alongside some topical approaches. (dentalcare.com)
  • Waardenburg syndrome type IV is autosomal recessive with variable penetrance and is due to SOX10 or endothelin-B receptor ( EDNRB ) gene mutations, which appear to correlate with the intestinal and/or neurological symptoms manifested in patients. (medscape.com)
Autoimmune1
Abnormalities3
  • Despite there being no visible evidence of the condition, psychological problems such as emotional stress, anxiety and depression, hormonal deficiencies in post-menopausal women and neurological abnormalities have all been identified as possible contributors of burning mouth syndrome. (dentalcare.com)
  • Mutations of potassium channels in the Kv and Kir families cause diseases of the brain (epilepsy, episodic ataxia), ear (deafness), kidney (hypertension), pancreas (hyperinsulinemic hypoglycemia of infancy), heart (arrhythmia), skeletal muscle (periodic paralysis), as well as developmental abnormalities of neural crest-derived tissues (Andersen's syndrome). (ucsf.edu)
  • Klein-Waardenburg Syndrome refers to a disorder that also includes upper limb abnormalities. (umassmed.edu)
Cutaneous1
  • Our patient presents a 5-month history of increasing inflammatory right thumb pain concomitant with the discovery of a subcutaneous hard mass (A). Radiographs of her thumb showed a sub-cutaneous calcification (as another part of the CREST syndrome criteria) (B). X-rays of hands found an acro-osteolysis (C). In the CREST syndrome , the calcific deposits can be subclinical. (lookformedical.com)
Neural crest development4
  • Does neural crest development drive domestication syndrome? (genestogenomes.org)
  • Altered neural crest development could be the reason mammals change in oddly consistent ways during domestication. (genestogenomes.org)
  • We hypothesized that the CNV causes aberrant expression of TWIST2 during neural crest development, which might negatively affect melanoblasts. (plos.org)
  • It is thought that these belted phenotypes are due to downregulated melanoblast formation or early melanoblast losses in neural crest development. (plos.org)
Tissues4
  • Waardenburg syndrome is a rare disease characterized by deafness in association with pigmentary anomalies and defects of neural crest-derived tissues. (medscape.com)
  • Morbidity is related to deafness and to defects of neural crest-derived tissues, including mental retardation, seizures, psychiatric disorders, skeletal anomalies, and eye disorders (including cataracts). (medscape.com)
  • Wilkins and Wrangham set about listing these mysterious marks of domestication and trying to match them to tissues affected by the neural crest. (genestogenomes.org)
  • Platt observed that in the mudpuppy (Necturus maculosus), the coordinated migration of neural crest cells in the embryo produced parts of the nervous system, bones, and connective tissues in the head. (asu.edu)
Embryonic4
  • Enteric ganglion cells are derived from the neural crest during embryonic development. (medscape.com)
  • The two scientists had run into each other at the photocopier when Wrangham noticed Wilkins was reading about a group of embryonic cells called the neural crest and its involvement in facial development. (genestogenomes.org)
  • 2011. Gdnf is mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon. (oup.com)
  • During embryonic development melanocytes are formed from melanoblasts, which originate in the neural crest and migrate through the developing embryo in order to reach their final position on the body [ 2 ]. (plos.org)
Disorders1
  • argue that their ideas dovetail with certain effects of human neural crest cell disorders, like the patches of depigmented skin and hair seen in Waardenburg syndrome or the jaw, ear and teeth phenotypes of Treacher Collins syndrome. (genestogenomes.org)
Dysfunction1
  • In addition, pregnancy often leads to stretching of the pelvis, specifically targeting the sacroiliac ligaments and possibly leading to dysfunction, hypermobility syndromes, and chronic pain. (medscape.com)
19801
  • Meyer O. [From Thibierge-Weissenbach syndrome (1910) to anti-centromere antibodies (1980). (medscape.com)
Migrate2
  • In their model, the vagal crest cells normally do not migrate in a directed manner once they are in the anterior portion of the gut. (oup.com)
  • The mechanism has not been precisely identified, but may include failure of the cervical neural crest cells to differentiate and migrate into the derivatives of the pharyngeal pouches and arches, deficient blastogenesis as a result of defective interaction between mesoderm and neural crest cells, and failure of mesoderm formation. (mhmedical.com)
Waardenburg Syndrome15
  • Children with Waardenburg syndrome have a normal life expectancy. (medscape.com)
  • Waardenburg syndrome types 1 and 3 are most commonly associated with point mutations in PAX3, and type 2 is associated with MITF point mutations. (medscape.com)
  • No effective treatment is available for persons with Waardenburg syndrome. (medscape.com)
  • Lack of resources in some societies may add to the physical and psychological obstacles faced by persons with Waardenburg syndrome. (medscape.com)
  • Tolerance and understanding of persons with Waardenburg syndrome help support their integration into society. (medscape.com)
  • No effective surgical care is available except cochlear implantation in children with Waardenburg syndrome, which can improve the speech perception ability. (medscape.com)
  • Consultations with a geneticist are important since Waardenburg syndrome type I is an autosomal dominant disease and some affected persons have relatives with the same disease. (medscape.com)
  • Waardenburg syndrome is a rare disease with an autosomal dominant mode of inheritance. (medscape.com)
  • The deficient neural crest theory, suggesting a developmental abnormality of the neural crest as a cause of the disease: The association of Waardenburg syndrome and congenital aganglionic megacolon supports this hypothesis. (medscape.com)
  • None of these possibilities explains all the features of Waardenburg syndrome. (medscape.com)
  • Genes responsible for syndromic forms of hearing loss in Waardenburg syndrome include PAX3 on band 2q37, observed in types I and III, and MITF mapped on 3p12-p 14.1 for type II. (medscape.com)
  • Waardenburg Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Waardenburg Syndrome" by people in this website by year, and whether "Waardenburg Syndrome" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Waardenburg Syndrome" by people in Profiles. (umassmed.edu)
  • Dysplasia of the cerebellum in Waardenburg syndrome: outcomes following cochlear implantation. (umassmed.edu)
Manifestations2
  • She had typical CREST Syndrome manifestations with complete heart block(CHB). (who.int)
  • We study the genetics of these cancer syndromes , the molecular basis of the associated clinical manifestations and in particular, the molecular pathogenesis of the associated tumors. (germanstrias.org)
Congenital1
  • A potentially life-threatening, congenital multiple-malformation syndrome. (mhmedical.com)
Overlap1
  • Nodular regenerative hyperplasia of the liver, CREST syndrome and primary biliary cirrhosis: an overlap syndrome? (bmj.com)
Prevalence2
  • Interventions promoting physical activ- ity should be developed and implemented in phases in high-prevalence ic syndrome. (cdc.gov)
  • 1] In the decades since then, several attempts have been made to establish the prevalence of SIJ syndrome in persons with back pain, and the results of these reports vary widely. (medscape.com)
Migration5
  • mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. (xenbase.org)
  • So subtle changes in neural crest cell numbers, migration, or proliferation would lead to widespread phenotypic effects. (genestogenomes.org)
  • The blue tube indicates the approximate position of the neural crest in the early embryo, and the blue arrows indicate pathways of neural crest cell migration. (genestogenomes.org)
  • Glial-derived neurotrophic factor (GDNF) activates cell division, directs cell migration into the gut mesoderm, and induces neural differentiation in the enteric neural crest cells, the neural crest from the vagal and sacral regions (Mwizerwa et al. (oup.com)
  • By combining experimental analysis of crest cell migration with mathematical modeling, Landman and colleagues (2007) modeled the migration of the vagal crest cells and explained the genetic deficiencies that cause Hirschsprung disease. (oup.com)
Developmental2
  • CHARGE Syndrome is a midline developmental defect attributed to an arrest in embryologic differentiation during early organogenesis. (mhmedical.com)
  • Originally named the Mongoloid Developmental Council, NADS is one of the oldest organizations serving people with Down syndrome and their families in the United States. (asu.edu)
Disease5
  • In the midst of filming "Willing to Fly", Deanna became ill with a little known disease called CREST syndrome. (normankent.com)
  • 2011). If either GDNF or Ret is deficient in mice or humans, the pup or child suffers from Hirschsprung disease, a syndrome wherein the intestine cannot properly void solid wastes. (oup.com)
  • His top areas of expertise are Necrosis, Acute Kidney Failure, Hepatorenal Syndrome, and Chronic Kidney Disease. (medifind.com)
  • His top areas of expertise are Minimal Change Disease, Nephrotic Syndrome, Glomerulonephritis, and Focal Segmental Glomerulosclerosis. (medifind.com)
  • In the landmark clinical trial, researchers infused a patient's blood with gene-editing tools, aiming to treat a severe inherited disease known as Hunter syndrome. (california.com)
Anomalies1
  • Eye anomalies in a 3-month-old boy with CHARGE Syndrome. (mhmedical.com)
Defects1
  • depleted Xenopus embryos: A model to study the pathogenesis of craniofacial defects in Nager syndrome. (xenbase.org)
Anomaly1
  • Anomaly of the ear in the same baby with CHARGE Syndrome. (mhmedical.com)
Patients4
  • [ 6 ] reviewed 13 patients with CREST and CRST syndromes and found the syndromes equivalent. (medscape.com)
  • RÉSUMÉ La présente étude a évalué la prévalence du syndrome métabolique et ses composantes selon les critères de l'Adult Treatment Panel III chez des patients jordaniens consultant dans un établissement de soins en médecine familiale pour la prise en charge des facteurs de risque cardio-vasculaires. (who.int)
  • Invasive hemodynamic parameters in patients with hepatorenal syndrome. (medifind.com)
  • Thirteen percent of patients with mesenteric fibromatosis have familial adenomatous polyposis (FAP), specifically, the Gardner syndrome variant of FAP [ 2 , 4 ]. (hindawi.com)
Synonyms1
  • Hall-Hittner Syndrome (both synonyms are now obsolete). (mhmedical.com)
20161
  • The number of people who died of an overdose increased by 2,200 plaquenil for crest syndrome or by 4 percent since 2016, with an additional 2,300 deaths in 2017. (sexsmithselfstorage.com)