CREST Syndrome: A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.Telangiectasis: Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.Syndrome: A characteristic symptom complex.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Arteritis: INFLAMMATION of any ARTERIES.Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.Surgical Instruments: Hand-held tools or implements used by health professionals for the performance of surgical tasks.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Esophageal Motility Disorders: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Platelet Count: The number of PLATELETS per unit volume in a sample of venous BLOOD.Partnership Practice, Dental: A voluntary contract between two or more dentists who may or may not share responsibility for the care of patients, with proportional sharing of profits and losses.Scleroderma, Limited: The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.Sick Building Syndrome: A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Ligaments, Articular: Fibrous cords of CONNECTIVE TISSUE that attach bones to each other and hold together the many types of joints in the body. Articular ligaments are strong, elastic, and allow movement in only specific directions, depending on the individual joint.Sacroiliac Joint: The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.Obturator Nerve: A nerve originating in the lumbar spinal cord (L2 to L4) and traveling through the lumbar plexus to the lower extremity. The obturator nerve provides motor innervation to the adductor muscles of the thigh and cutaneous sensory innervation of the inner thigh.Ilium: The largest of three bones that make up each half of the pelvic girdle.Ligaments: Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Complex Regional Pain Syndromes: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)Gastric Antral Vascular Ectasia: A distinct vascular lesion in the PYLORIC ANTRUM that is characterized by tortuous dilated blood vessels (ectasia) radiating outward from the PYLORUS. The vessel pattern resembles the stripes on the surface of a watermelon. This lesion causes both acute and chronic GASTROINTESTINAL HEMORRHAGE.Stomach Diseases: Pathological processes involving the STOMACH.Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Neural Crest: The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.Heart: The hollow, muscular organ that maintains the circulation of the blood.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.ReadingHorner Syndrome: A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)Abducens Nerve Diseases: Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.Mydriasis: Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.Carotid Artery, Internal, Dissection: The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.Autonomic Pathways: Nerves and plexuses of the autonomic nervous system. The central nervous system structures which regulate the autonomic nervous system are not included.Pupil: The aperture in the iris through which light passes.Facial Paralysis: Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.Dried Blood Spot Testing: Techniques for using whole blood samples collected on filter paper for a variety of clinical laboratory tests.PaperBlood Stains: Antigenic characteristics and DNA fingerprint patterns identified from blood stains. Their primary value is in criminal cases.Blood Specimen Collection: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Filtration: A process of separating particulate matter from a fluid, such as air or a liquid, by passing the fluid carrier through a medium that will not pass the particulates. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Neonatal Screening: The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Skin Neoplasms: Tumors or cancer of the SKIN.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Licensure: The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.Moral Obligations: Duties that are based in ETHICS, rather than in law.

Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases. (1/32)

A duplication in the fibrillin-1 gene has been implicated as the cause of the tight skin 1 (tsk1) phenotype, an animal model of scleroderma or systemic sclerosis (SSc). In addition to the production of abnormal fibrillin-1 protein, the tsk1 mouse also produces autoantibodies to fibrillin-1. Among a population of Choctaw Native Americans with the highest prevalence of SSc yet described, a chromosome 15q haplotype containing the fibrillin-1 gene has been strongly associated with SSc. With a recombinant human fibrillin-1 protein, autoantibodies to fibrillin-1 were detected in the sera of Native American SSc patients that correlated significantly with disease. Abs to fibrillin-1 also were detected in sera from Japanese, Caucasian, and African-American SSc patients. Compared with other ethnic groups, Japanese and Native American SSc patients had significantly higher frequencies of anti-fibrillin-1 Abs. Sera from patients with diffuse SSc, calcinosis, Raynaud's, esophageal dysmotility, sclerodactyly, and telangiectasias syndrome and mixed connective tissue disease also had significantly higher frequencies of anti-fibrillin-1 Abs than sera from controls or patients with other non-SSc connective tissue diseases (lupus, rheumatoid arthritis, and Sjogren's syndrome). Ab specificity for fibrillin-1 was demonstrated by the lack of binding to a panel of other purified autoantigens. The results presented demonstrate for the first time the presence of high levels of anti-fibrillin-1 Abs in a significant portion of patients with SSc.  (+info)

Phlebosclerosis of the colon with positive anti-centromere antibody. (2/32)

A 56-year-old woman with symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enema study. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. No cell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CREST syndrome were observed. We therefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CREST syndrome.  (+info)

The mammalian centromere: structural domains and the attenuation of chromatin modeling. (3/32)

The centromere-kinetochore complex can be divided into distinct domains based on structure and function. Previous work has used CREST auto-antibodies with various microscopic techniques to map the locations of proteins within the centromere-kinetochore complex and to analyze the maturation of prekinetochores before mitosis. Here we have focused on the centromere-specific histone Centromere Protein (CENP)-A and its spatial relationship to other histones and histone modifications found in condensed chromatin. We demonstrate that the phosphorylation of histone H3 is essentially excluded from a specific region of centromeric chromatin, defined by the presence of CENP-A. Interspersion of CENP-B with phosphorylated H3 in the inner centromere indicates that the exclusion of H3 modification is not a general property of alpha-satellite DNA. We also demonstrate that these regions are functionally distinct by fragmenting mitotic chromatin into motile centromere-kinetochore fragments that contain CENP-A with little or no phosphorylated H3 and nonmotile fragments that contain exclusively phosphorylated H3. The sequence of CENP-A diverges from H3 in a number of key residues involved in chromosome condensation and in transcription, potentially allowing a more specialized chromatin structure within centromeric heterochromatin, on which kinetochore plates may nucleate and mature. This specialized centromere subdomain would be predicted to have a very tight and static nucleosome structure as a result of the absence of H3 phosphorylation and acetylation.  (+info)

Clinical, serological and genetic study in patients with CREST syndrome. (4/32)

OBJECTIVE: To assess the clinical, serological and genetic features of Japanese patients with CREST syndrome. PATIENTS AND METHODS: Clinical features, autoantibodies and human histocompatibility leukocyte antigen (HLA) typing were studied in thirty patients with CREST syndrome, including 29 females and one male, with a mean age of 59.0 years (ranging from 40 to 76 years). RESULTS: Interstitial pneumonia on chest X-ray and renal involvement were rare. Mitral regurgitation and tricuspid regurgitation were present in 56.7% and 76.7%, respectively. Sjoren's syndrome (SS) and primary biliary cirrhosis (PBC) were highly associated, however the positivity of the marker antibodies to those syndromes, such as anti-SSA, anti-SSB, anti-mitochondrial (AMA) and anti-smooth muscle autoantibodies were less frequent than that of primary SS and PBC without the other autoimmune diseases. The histological findings of PBC were all early stages in Scheuer's classification. HLA-Cw6 were associated with CREST-PBC overlap syndrome (p<0.05). However the HLA antigen was not correlated with CREST syndrome, and the frequency of HLA-DR2 between CREST syndrome with or without PBC was significantly different (p<0.01). CONCLUSION: It was suggested that there was a genetic difference between CREST syndrome alone and CREST-PBC overlap syndrome and there were differences (the positivity of AMA and the severity of bile duct lesion) between PBC and CREST-PBC overlap syndrome.  (+info)

Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome? (5/32)

OBJECTIVE: We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis. RESULTS: Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy. CONCLUSIONS: From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.  (+info)

Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome. (6/32)

A 58-year-old woman with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome presented with slowly progressive renal dysfunction. She was normotensive with normal plasma renin activity and lacking symptoms of vasculitis. Mild proteinuria was of tubular origin, but serological tests and an absence of sicca symptoms excluded the possibility of Sjogren's syndrome. Light microscopic study of renal biopsy showed interstitial fibrosis with ectasia and degeneration of proximal tubule and lymphocyte infiltration. There were no remarkable changes in the glomeruli. Chromatographic analysis of the Chinese herbs regimen that she had been taking for several years demonstrated aristolochic acid. She was diagnosed as Chinese herbs nephropathy. Therapy with oral prednisolone was markedly effective in improving renal function and anemia. To our knowledge, this is the first report of Chinese herbs nephropathy complicating connective tissue disease. It is important to consider the possibility of Chinese herbs nephropathy when patients treated with Chinese herbs develop renal dysfunction.  (+info)

Induction of kinetochore-positive and kinetochore-negative micronuclei in CHO cells by ELF magnetic fields and/or X-rays. (7/32)

To test the genotoxic effects of extremely low frequency (ELF) magnetic fields, the induction of micronuclei by exposure to ELF magnetic fields and/or X-rays was investigated in cultured Chinese hamster ovary (CHO) cells, using the cytokinesis block method. Micronuclei derived from acentric fragments or from whole chromosomes were evaluated by immunofluorescent staining using anti-kinetochore antibodies from the serum of scleroderma (CREST syndrome) patients. A 60 Hz ELF magnetic field at 5 mT field strength was applied, either before or after 1 Gy X-ray irradiation or without additional X-ray irradiation. No statistically significant difference in the frequency of micronuclei in CHO cells was observed between a sham exposure (no exposure to an ELF magnetic field) and a 24 h ELF magnetic field exposure. Exposure to an ELF magnetic field for 24 h before X-ray irradiation or for 18 h after X-ray irradiation did not affect the frequency of X-ray-induced micronuclei. However, the number of kinetochore-positive micronuclei was significantly increased in the cells subjected to X-ray irradiation followed by ELF magnetic field exposure, but not in the cells treated with ELF magnetic field exposure before X-ray irradiation, compared with exposure to X-rays alone. The number of spontaneous kinetochore-positive and kinetochore-negative micronuclei was not affected by exposure to an ELF magnetic field alone. Our data suggest that exposure to an ELF magnetic field has no effect on the number of spontaneous and X-ray-induced micronuclei. However, ELF magnetic field exposure after but not before X-ray irradiation may somehow accelerate X-ray-induced lagging of whole chromosomes (or centric fragments) in CHO cells.  (+info)

Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. (8/32)

Centrosome is the major microtubule organizing center in mammalian cells that plays a critical role in a variety of cellular events by the microtubule arrays emanating from it. Despite its significance, the molecular mechanisms underlying the structure and function of the centrosome are still not clear. Herein we describe the identification of three isotypes of human ninein by expression library screening with autoimmune sera from CREST patients. All three ninein isotypes exhibit centrosomal localization throughout the cell cycle when GFP-tagged fusion proteins are expressed transiently in mammalian cells. Construction of serial deletions of GFP-tagged ninein reveals that a stretch of three leucine zippers with a flanking sequence is required and sufficient for centrosomal targeting. Overexpression of ninein results in mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules. In these cells, nucleation of microtubules from the centrosome is also inhibited. These results thus suggest a regulatory role for ninein in microtubule nucleation.  (+info)

*CREST syndrome

... can be noted in up to 10% of patients with primary biliary cirrhosis. The combination of symptoms was first ... CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue ... Other symptoms of CREST syndrome can be exhaustion, weakness, difficulties with breathing, pain in hands and feet, dizziness ... Crest syndrome involves the production of autoimmune anti-nuclear and anti-centromere antibodies, though their cause is not ...

*Anti-topoisomerase antibodies

... but is also seen the more limited form of systemic scleroderma called CREST syndrome. However, CREST syndrome is more closely ...

*Raynaud syndrome

This may be the case in the CREST syndrome, of which Raynaud's is a part. Patients with Secondary Raynaud's can also have ... Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which spasm of arteries cause episodes of ... Sjögren's syndrome dermatomyositis polymyositis mixed connective tissue disease cold agglutinin disease Ehlers-Danlos syndrome ... disease hypothyroidism cryoglobulinemia malignancy chronic fatigue syndrome reflex sympathetic dystrophy carpal tunnel syndrome ...

*Prepatellar bursitis

Other possible causes include gout, sarcoidosis, CREST syndrome, diabetes mellitus, alcohol abuse, uremia, and chronic ...

*Calcinosis cutis

In addition, calcinosis is seen in Limited Cutaneous Systemic Sclerosis, also known as CREST syndrome (the "C" in CREST). In ... Calcinosis cutis in a dog with Cushing's syndrome Calcinosis cutis in human tissue Calcinosis List of cutaneous conditions ...

*Anti-nuclear antibody

Anti-centromere antibodies are associated with limited cutaneous systemic sclerosis, also known as CREST syndrome, primary ... In Sjögren's syndrome, anti-Ro and anti-La antibodies correlate with early onset, increased disease duration, parotid gland ... The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of ... Anti-La antibodies are also found in SLE; however, Sjögren's syndrome is normally also present. Anti-Ro antibodies are also ...

*Esophageal motility disorder

It is a part of CREST syndrome, referring to the five main features: calcinosis, Raynaud syndrome, esophageal dysmotility, ... CREST syndrome, or achalasia). Esophageal disease Esophageal motility study Esophageal spasm GERD (Gastroesophageal Reflux ... a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins Hospital 114: 361-83. PMID 14171636 ...

*Betty Jane Cornett

... retiring in 1987 after being diagnosed with CREST syndrome. After that, she was invited to several AAGPBL Players Association ...

*Anti-centromere antibodies

They occur in some autoimmune diseases, frequently in limited systemic scleroderma (formerly called CREST syndrome), and ...

*Scleroderma

One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal ... causing a limited systemic form and the CREST syndrome). Other autoantibodies can be seen, such as anti-U3 or anti-RNA ... Eosinophilia-myalgia syndrome, a form of eosinophilia that is caused by L-tryptophan supplements. Eosinophilic fasciitis, a ... Musculoskeletal: joint, muscle aches, loss of joint range of motion, carpal tunnel syndrome and muscle weakness. Genitourinary ...

*Esophagus

Sclerosis of the esophagus, such as with systemic sclerosis or in CREST syndrome may cause hardening of the walls of the ... Half of these cases may be part of a syndrome where other abnormalities are also present, particularly of the heart or limbs. ... Strictures may also develop in chronic anemia, and Plummer-Vinson syndrome. Two of the most common congenital malformations ...

*Richard Zoumalan

Association of an Irregular Anterior Choroidal Aneurysm With CREST Syndrome. A case report. Journal of Neurosurgery. 2004 Nov; ...

*List of diseases (C)

... see also CREST syndrome) Calciphylaxis Calculi Calderon-Gonzalez-Cantu syndrome Calloso genital dysplasia Callus disease ... CCA syndrome Ccge syndrome CCHS CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome ... syndrome COFS syndrome Cogan-Reese syndrome Cogan syndrome Cohen-Hayden syndrome Cohen-Lockood-Wyborney syndrome Cohen syndrome ... syndrome type 1 Cockayne syndrome type 2 Cockayne syndrome type 3 Cockayne's syndrome Codas syndrome Codesette syndrome Coeliac ...

*Anti-Scl-70 antibodies

... of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with ...

*List of MeSH codes (C06)

... crest syndrome MeSH C06.405.117.119.500.432 --- esophageal achalasia MeSH C06.405.117.119.500.450 --- esophageal spasm, diffuse ... gardner syndrome MeSH C06.405.469.578.750 --- peutz-jeghers syndrome MeSH C06.405.469.600 --- jejunal diseases MeSH C06.405. ... zollinger-ellison syndrome MeSH C06.552.150.125 --- alagille syndrome MeSH C06.552.150.250 --- liver cirrhosis, biliary MeSH ... postgastrectomy syndromes MeSH C06.405.748.630.310 --- dumping syndrome MeSH C06.405.748.789 --- stomach neoplasms MeSH C06.405 ...

*Nitric oxide

... and pulmonary edema in patients with CREST syndrome. Nitric oxide is a compound produced by many cells of the body. It relaxes ... In the adult ICU setting, inhaled ·NO can improve hypoxemia in acute lung injury, acute respiratory distress syndrome, and ...

*List of cutaneous conditions

Calcinosis-Raynaud phenomenon-esophageal dysmotility-sclerodactyly-telangiectasia syndrome (CREST syndrome) Chilblain lupus ... Turner syndrome Ulnar-mammary syndrome Van Der Woude syndrome Von Hippel-Lindau syndrome Watson syndrome Werner syndrome (adult ... Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome) Wilson-Turner syndrome Wolf-Hirschhorn syndrome (4p- syndrome) X-linked ... Rombo syndrome Rothmund-Thomson syndrome (poikiloderma congenitale) Rud syndrome Say syndrome Scalp-ear-nipple syndrome (Finlay ...

*List of MeSH codes (C17)

... crest syndrome MeSH C17.800.030.030 --- acne keloid MeSH C17.800.030.150 --- acne vulgaris MeSH C17.800.090.249 --- breast cyst ... crest syndrome MeSH C17.800.794.111 --- acne vulgaris MeSH C17.800.794.230 --- dermatitis, seborrheic MeSH C17.800.794.550 --- ... tietze's syndrome MeSH C17.300.200.310 --- ehlers-danlos syndrome MeSH C17.300.200.425 --- keloid MeSH C17.300.200.425.125 --- ... stevens-johnson syndrome MeSH C17.800.229.413 --- erythema nodosum MeSH C17.800.229.413.800 --- sweet's syndrome MeSH C17.800. ...

*List of MeSH codes (C18)

... crest syndrome MeSH C18.452.174.130.560 --- nephrocalcinosis MeSH C18.452.174.289 --- decalcification, pathologic MeSH C18.452. ... melas syndrome MeSH C18.452.100.100.540 --- menkes kinky hair syndrome MeSH C18.452.100.100.545 --- merrf syndrome MeSH C18.452 ... melas syndrome MeSH C18.452.648.151.450 --- menkes kinky hair syndrome MeSH C18.452.648.151.505 --- merrf syndrome MeSH C18.452 ... li-fraumeni syndrome MeSH C18.452.284.600 --- nijmegen breakage syndrome MeSH C18.452.284.760 --- rothmund-thomson syndrome ...

*List of causes of shortness of breath

Scoliosis Disorders of the cardiovascular system Aortic dissection Cardiomyopathy Congenital heart disease CREST syndrome Heart ... syndrome Multiple sclerosis Myasthenia gravis Parsonage Turner syndrome Eaton-Lambert syndrome Chronic fatigue syndrome ... primary or secondary Pulmonary veno-occlusive disease Superior vena cava syndrome Obstruction of the airway Cancer of the ... larynx or pharynx Empty nose syndrome Pulmonary aspiration Epiglottitis Laryngeal edema Vocal cord dysfunction Immobilization ...

*List of MeSH codes (C14)

... crest syndrome MeSH C14.907.790.100 --- anterior spinal artery syndrome MeSH C14.907.790.550 --- spinal cord ischemia MeSH ... crest syndrome MeSH C14.907.823.780 --- telangiectasia, hereditary hemorrhagic MeSH C14.907.863.200 --- cervical rib syndrome ... long qt syndrome MeSH C14.280.067.565.070 --- andersen syndrome MeSH C14.280.067.565.440 --- jervell-lange nielsen syndrome ... behcet syndrome MeSH C14.907.940.110 --- Churg-Strauss syndrome MeSH C14.907.940.560 --- mucocutaneous lymph node syndrome MeSH ...

*ABCD syndrome

"Autosomal-recessive neural crest syndrome with albinism, black lock, cell migration disorder of the neurocytes of the gut, and ... Researchers began discussing the possibility that ABCD syndrome was in fact not a syndrome; rather it was a type of another ... This helped scientists discover that it is the same as type IV Waardenburg syndrome, also known as Shah-Waardenburg syndrome. ... In the beginning, medical officials defined ABCD syndrome by the four key characteristics of the syndrome. In the first case ...

*ZNF74

Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M (2000). "ZNF74, a gene deleted in DiGeorge syndrome, is expressed ... in human neural crest-derived tissues and foregut endoderm epithelia". Genomics. 62 (1): 82-5. doi:10.1006/geno.1999.5982. PMID ... "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome". Hum. Mol. Genet. 2 (10): 1583-7. doi:10.1093/hmg/ ...

*JAG1

"Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients". Hum. Mol. ... GeneReviews/NCBI/UW/NIH entry on Alagille syndrome OMIM entries on Alagille syndrome JAG1 protein, human at the US National ... McCright B, Lozier J, Gridley T (2002). "A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 ... Notch signaling Alagille syndrome Autosomal dominant Haploinsufficiency Tetralogy of fallot In situ hybridization Conditional ...

*PACS1

... mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome". ... colloquially called PACS1 Syndrome) that is characterized by global developmental delay, intellectual disability, and specific ...

*Spinal cord

Strümpell-Lorrain syndrome) Poliomyelitis, Post-polio syndrome Upper-limb surgery in tetraplegia Redlich-Obersteiner's Zone ... Dorsal root ganglion neurons differentiate from neural crest progenitors. As the dorsal and ventral column cells proliferate, ... Neutral spine Brown-Séquard syndrome Hereditary spastic paraplegia (HSP, or Familial spastic paraplegia - FSP, ... Subacute combined degeneration of spinal cord Tethered spinal cord syndrome Maton, Anthea; et al. (1993). Human biology and ...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
We report a case of 62-year-old Tunisian woman with a 10-year history of a CREST syndrome (systemic sclerosis meeting the criteria of the CREST syndrome of the 1980 American College of Rheumatology classification for raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Her daughter is treated in neurology for myasthenia gravis. Our patient presents a 5-month history of increasing inflammatory right thumb pain concomitant with the discovery of a subcutaneous hard mass (A). Radiographs of her thumb showed a sub-cutaneous calcification (as another part of the CREST syndrome criteria) (B). X-rays of hands found an acro-osteolysis (C). In the CREST syndrome, the calcific deposits can be subclinical. But, when symptomatic, it becomes painful, tender and an inflammatory reaction can occur facing the calcinosis.
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension. CREST causes thickening and tightening of the skin with deposition of calcific nodules ("calcinosis"). Raynauds phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. Stress and cold temperature induce an exaggerated vasoconstriction of the small arteries, arterioles, and thermoregulatory vessels of the skin of the digits. Clinically this manifests as a white-blue-red transitions in skin ...
Crest syndrome is an acronym for Calcinosis; Reynaudssyndrome; Esophagealdysmotility; Sclerodactyly and Telangiectasia. It is also known as Limited
Tips to help with your thrombocytopenia: Crest Syndrome Thrombocytopenia. My thrombocytopenia, Online resources for thrombocytopenia.
The answer to yesterdays mystery is … limited scleroderma (a.k.a. CREST syndrome)! Great job Priscilla, Kmu, American Girl Mommy, Erin, Rich S, guest, OB1, Phung, Shelly Langlois, mabel, vor120806, Kimberly Helton, CB, Kelly, ColorMaven, Jerry Skrocki, Amanda, Michelle, Tina M., Angelita, ER SEC, Mary, todd dombrowski, JP3, kim labounty, Dazed & Confused, JB, and PJ.. Ill give partial credit to those who named one component of CREST syndrome, Raynauds phenomenon: D2, Patti Ann, Carol, MG, Gracie287, GetAClue, Zach A., Tara Naz, Robert Jones, the other Naomi, Shannon Vincent, Martha, sallad, Michele Liguori, Veronica, Deborah Cote, JP, and GG.. CREST syndrome, or limited cutaneous systemic scleroderma, is an autoimmune disease that causes scarring of different tissues in the body, most notably the skin. The cause of the disease is unknown, but it is likely some combination of genetic factors and environmental triggers. First, inflammatory white blood cells infiltrate the skin and ...
CREST syndrome A less severe form of scleroderma is called CREST.. The CREST syndrome represents symptoms including calcium skin deposits; Raynauds phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous); esophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach); sclerodactyly (skin damage on fingers); and telangiectasia (spider veins), limits skin damage to the fingers.. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure.. ...
Without Raynauds you cannot diagnose Scleroderma. I think it is completely unprofessional for your doctor to say you have this, or even suspect it - since hes not a rheumatologist. If you dont have Raynauds you dont have this... Something like 98% of those with Scleroderma have very severe Raynauds. Multiple people on this board have Raynauds, but were talking severe Raynauds where your fingers turn mutliple colors and you literally have to put them under warm water to get them back to normal ...
Main page of ISN Scleroderma Symptom Photo Repository. Pictures include images of amputations, calcinosis, hand contractures, CREST syndrome, gangrene, Raynauds, sclerodactyly, and telangeiectasia.
The Raynauds phenomenon is named after the French doctor who first wrote about in the 1850. There is Raynauds phenomenon or simply Raynauds is a disorder to the characterized by decreased blood flow usually to the fingers and less frequently to the ears, toes, nipples, knees, or nose. The Raynauds can occur alone or may occur with other diseases. The diseases most frequently by the associated with Raynauds are autoimmune or connective tissue diseases, among others, such as the followings are systemic lupus erythematous and scleroderma and CREST syndrome, Buergers disease, polymyositis, Sjogrens syndrome, occlusive vascular disease, rheumatoid arthritis, cryoglobulinemia. They are one theory links blood disorders to the characterized by increased platelets or red blood cells that may increase the blood thickness. The phenomenon of heart disease will be varying from one person to another person in the real world.. Risk Factor:. The risk of factor is anything that may be increases a persons ...
By: Connie ODonnell How Scleroderma and Paraplegia can have a bright spot in the lives of one couple.. I was not diagnosed with Scleroderma Crest Syndrome until I was into my 50s, but suffered from Raynauds and painful finger ulcers for many years. There isnt a photo of me that I am not sporting bandaids on my fingers. Finally these drove me to a doctor, then a wound care facility. I suffered through much painful debriding until finally I had to have my index fingers amputated. I am an artist and initially this procedure was devastating. However, over the years, my fingers have stiffened and become bent, but I have managed to adapt. I am now almost 65 and still draw and paint, and can diaper a grand child with some difficulty. Six years ago my husband suffered a spinal cord injury and is paralyzed just below his arms. We consider ourselves lucky. He is the hands and I am the legs in our relationship, so together we are a whole.....or somewhat close to one.. ...
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs in addition to the skin. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynauds syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small dilated blood vessels. The cause is unknown. Risk factors include family history, certain genetic factors, and exposure to silica. The underlying mechanism involves the abnormal growth of connective tissue which is believed to occur as a result of the bodys immune system attacking healthy tissues. Diagnosis is typically based on a persons symptoms and may be supported by a skin biopsy or blood tests. While there is no cure, treatments may ...
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Learn all about sclerodactyly, a condition that can cause the hands to take on a claw shape. This article looks at the symptoms, causes, and treatment.
Raynaud phenomenon is known to occur in around 10% of the healthy female population and in around 5% of men. In the vast majority of cases, the blood vessels show no evidence of damage. In this case - so called Primary Raynaud phenomenon - the issue appears to be exaggerated spasm of healthy blood vessels.. Raynaud phenomenon is also the most common first symptom of scleroderma and is an important feature in other rheumatologic illnesses such as lupus. In this situation, the blood vessels are damaged and the opening for blood flow is much reduced. Raynaud episodes in scleroderma may reflect normal blood vessel constriction in response to cold superimposed on the narrow plumbing.. Blood flow to the fingers in normal health is around 40 times as much as is needed for oxygen supply and tissue nutrition. When the body is hot, blood flow increases to the hands so as to dissipate heat. This is much like a dog panting on a hot day. Conversely, when the body is cold, it is normal to reduce blood flow to ...
The symptoms of Raynauds phenomenon, arthralgia, and dysphagia point toward the diagnosis of scleroderma. Scleroderma, or systemic sclerosis, is characterized by a systemic vasculopathy of small and medium-sized vessels, excessive collagen deposition in tissues, and an abnormal immune system. It is an uncommon multisystem disease affecting women more often than men. There are two variants of scleroderma ;a relatively benign type called the CREST syndrome "C-calcinosis.R- raynaud phen. E- esophagal dysmotility.S-sclerodactyly.T-talangiectasia" and a more severe, diffuse disease ...
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogrens syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE.
The Waardenburg syndromes (WS) are rare genetic disorders described classically as neural crest syndromes and characterized by deafness and pigmentation abnormalities. WS type IV (WS4) is attributed to mutations in the SOX10 gene, which regulates pigment cell development. Here, Kirsten Dutton and colleagues study otic vesicle development using a zebrafish model of WS4, the colourless/sox10 mutant. WS4 patients and mutant fish display a similar spectrum of abnormalities in the ear, pigment cells and enteric neurons. Additionally, the researchers found that only a few neural crest cells contribute to the developing zebrafish ear, and therefore are unlikely to be wholly responsible for the resulting auditory deficits. Their work helps explain the origin of inner ear deficits that lead to hearing loss and vestibular problems in WS4 patients.. Page 68. ...
Metastatic calcinosis cutis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ) (costs for program #151501) ✔ University Hospital Münster ✔ Department of Gerneral Internal Medicine, Nephrology, Hypertension Diseases and Rheumatology (Medical Department D) ✔ BookingHealth.com
Definition of Raynaud's disease in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Raynaud's disease? Meaning of Raynaud's disease as a legal term. What does Raynaud's disease mean in law?
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Mr. Raynaud, a recent immigrant from France, finds employment as a high school literature teacher in the U.S. One day, a female student bursts into tears in the middle of class. Raynaud walks over
Raynaud's phenomenon, a disorder that affects the blood vessels in the fingers, toes, ears, and nose, can occur as a primary or secondary condition.
Looking for online definition of Raynaud syndrome in the Medical Dictionary? Raynaud syndrome explanation free. What is Raynaud syndrome? Meaning of Raynaud syndrome medical term. What does Raynaud syndrome mean?
Looking for online definition of Raynaud in the Medical Dictionary? Raynaud explanation free. What is Raynaud? Meaning of Raynaud medical term. What does Raynaud mean?
Considering a prevalence of 5-10% in the general population, there is still a place and probably a need for the development of new treatment concepts. Ginkgo biloba has shown to have anti-oxidative and anti-platelet activities. In a small placebo controlled trial in patients with the Raynaud´s phenomenon promising results for the Ginkgo biloba extract were shown. EGb 761® is known to be safe and well tolerated. Based on the above considerations, EGb 761® may be an effective treatment for Raynaud´s phenomenon.. Aim: To determine the efficacy and safety of EGb 761® in patients with Raynaud´s phenomenon on the frequency, duration, and severity of vasospastic attacks compared to placebo. ...
Scleroderma is a disease of the connective tissue featuring prominent skin thickening. Scleroderma can lead to scarring, blood vessel problems, varying degrees of inflammation, and is apparently a manifestation of an overactive immune system. Scleroderma is classified into localized scleroderma and systemic sclerosis. CREST syndrome is a limited form of systemic sclerosis. Patients with scleroderma can have specific antibodies (ANA, anticentromere or antitopoisomerase) in their blood, which strongly suggests an autoimmune etiology ...
CREST Syndrome (Limited Scleroderma) Systemic scleroderma, or systemic sclerosis, is the term for the disease that is characterized by diffuse thickening of the
Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogrens syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. ...
Not everyone with scleroderma develops this degree of skin hardening. However, it is this symptom that has earned scleroderma the nickname of the disease that turns people to stone.. Systemic scleroderma often affects the hands. The initial stage is swelling (edema), which can last for weeks, months, or years. Often the swelling is intermittent and worse in the morning. It can cause the fingers to look like sausages, with far fewer wrinkles. Skin tightness in the hands can make it impossible to pinch the skin on the fingers ...
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This is a photo of a calcium deposit (calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN Photo Repository.
Generation of a ninein polyclonal antibody. (A) Ninein is a 2096-chain amino acid protein. The 381-689 fragment of ninein (solid bar) was used to generate the n
This dissertation describes the results of a population-based case-control study of risk factors for five connective tissue diseases: systemic lupus erythematosus, Sjogrens syndrome, systemic sclerosis/CREST syndrome, polymyositis/dermatomyositis and mixed connective tissue disease.Cases were female residents of King County, Washington who were diagnosed by a rheumatologist between January 1, 1983 and December 31, 1991 as having a disease of interest. Two control groups were used. The new control group was identified by random digit telephone dialing and was frequency matched to the case group on age at diagnosis and calendar year of diagnosis. Mailed questionnaires were used for concurrent data collection on the cases and on the new control group, with a telephone administered questionnaire for non-respondents. The pre-existing control group had been used for three other epidemiologic studies, and was identified and had in-person interviews before 1992, when mass media attention to the ...
Reversible vasospasm of the extremities occurs as an isolated symptom in the absence of underlying disease (primary Raynaud phenomenon) or in association with other disorders (secondary Raynaud phenomenon). It has been reported that Raynaud phenomenon is associated with connective tissue diseases, but the frequency and types of diseases that eventually develop are not well established. Spencer-Green conducted a systematic literature search to assess the rates and predictors of transition to secondary disease after a primary diagnosis of Raynaud phenomenon.. A total of 639 patients with primary Raynaud phenomenon were identified from 10 studies. The average length of study follow-up was four years. The average duration of Raynaud phenomenon in the study subjects was 12.3 years. During follow-up, 12.6 percent (81 patients) developed a secondary disorder. Eighty of these cases were connective tissue diseases. Two thirds of the cases of connective tissue disease were attributed to systemic ...
Once a doctor has diagnosed Raynauds phenomenon, there are several simple, effective methods to help manage the symptoms. While there is no known cure for Raynauds phenomenon, people with the disease are usually able to manage their symptoms with medications and. behavior modification.. There are a number of strategies to treat the symptoms of Raynauds phenomenon. Most importantly, protecting the core body (hat, scarf, layered clothes) as well as the hand. s and. feet from cold temperatures will help prevent discomfort. Wearing gloves and. heavy socks in winter is a simple protection strategy. Some people with Raynauds phenomenon even find it helpful to wear cotton gloves or oven mitts reach into freezers, to protect sensitive hand. s and. reduce the risk of vasospasms.. People with Raynauds phenomenon should not smoke or be exposed to second-hand. smoke, as smoking restricts blood vessels and. can exacerbate the condition.. About the research. The research was conducted by the University ...
There is a need to improve the biological data, dosimetry, and risk assessment methodology used for setting guidelines for occupational exposures to extreme-low-frequency magnetic fields. This paper illustrates how a probabilistic approach can be used to determine priorities for future research based upon the analysis of biological and...
To the editor: In connection with the article by Vogelzang and associates (1) on Raynauds phenomenon and its relation to vinblastine-bleomycin therapy, we wish to describe a new case.. A 41-year-old man with an embryonal carcinoma in the mediastinum developed Raynauds phenomenon with distal necrosis in the third month of treatment with vinblastine, bleomycin, and cisplatin (2). An arteriogram showed multiple arterial occlusions; the findings of a rheumatologic diagnostic study (including cryoglobulins) were negative. He smoked, but had never before had Raynaud manifestations. The severe pain was relieved only with intra-arterial vasodilators.. This case calls attention to vinblastine-bleomycin as a ...
We report a 14-year-old girl with juvenile dermatomyositis (JDM) complicated by severe inflammatory calcinosis successfully treated with thalidomide. She was diagnosed as JDM when she was 4 years old after a few months of increasing lethargy, muscle pain, muscle weakness, and rash. During three months, clinical manifestations and abnormal laboratory findings were effectively treated with oral prednisolone. However, calcinosis was recognized 18 months after disease onset. Generalized calcinosis rapidly progressed with high fever, multiple skin/subcutaneous inflammatory lesions, and increased level of CRP. Fifty mg/day (1.3 mg/kg day) of oral thalidomide was given for the first four weeks, and then the dose was increased to 75 mg/day. Clinical manifestations subsided, and inflammatory markers had clearly improved. Frequent high fever and local severe pain with calcinosis were suppressed. The levels of FDP-E, IgG, and tryglyceride, which were all elevated before the thalidomide treatment, were gradually
The term scleroderma simply means hard skin. Many sufferers may have exhibited Raynauds phenomenon before they develop any signs of scleroderma. The skin signs include a stiffening of the skin of the fingers which becomes shiny and taut. The fingers feel stiff and gradually become less mobile and take on a characteristic appearance called sclerodactyly. The skin can also tighten in other areas such as on the face causing a small mouth. The skin becomes fragile causing dryness and ulcers ...
Question - How and why do hard calcium deposits form?. Ask a Doctor about diagnosis, treatment and medication for Calcinosis cutis, Ask a General & Family Physician
Scleroderma, Systemic;Endothelium;Fibroblasts;Raynaud Disease;Muscle, Smooth--cytology;Muscle, Smooth--metabolism;Rheumatic Diseases;Cells, Cultured; ...
Scleroderma, Systemic;Endothelium;Fibroblasts;Raynaud Disease;Muscle, Smooth--cytology;Muscle, Smooth--metabolism;Rheumatic Diseases;Cells, Cultured; ...
This test is done to find out if you have abnormal proteins in your blood. They can be a sign of rheumatoid arthritis, lupus, or Raynaud syndrome, among other illnesses.
This test is done to find out if you have abnormal proteins in your blood. They can be a sign of rheumatoid arthritis, lupus, or Raynaud syndrome, among other illnesses.
This test is done to find out if you have abnormal proteins in your blood. They can be a sign of rheumatoid arthritis, lupus, or Raynaud syndrome, among other illnesses.
Jensen, L. R.; Bartenschlager, H.; Rujirabanjerd, S.; Tzschach, A.; Nümann, A.; Janecke, A. R.; Spörle, R.; Stricker, S.; Raynaud, M.; Nelson, J. et al.; Hackett, A.; Fryns, J.-P.; Chelly, J.; de Brouwer, A. P. M.; Hamel, B.; Gecz, J.; Ropers, H.-H.; Kuss, A. W.: A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylose KDM5C. Pathogenetics 2 (3), p. 2 - 2 (2010 ...
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NIH Rare Diseases : 50 watermelon stomach is a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. although it can develop in men and women of all ages, watermelon stomach is most commonly observed in older women (over age 70 years). signs and symptoms of watermelon stomach include blood in the stool, hematemesis (vomiting blood) and anemia. the exact cause of watermelon stomach is unknown; however, it is often diagnosed in people with other chronic (long-term) conditions such as cirrhosis (scarring of the liver and poor liver function), autoimmune disease, systemic sclerosis, and crest syndrome. treatment consists of surgery and/or medications to stop or control the bleeding. last updated: 8/2/2016 ...
Disclosures:. Dr. Fasanella has reported no relevant relationships with proprietary entities producing health care goods or services.. All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.. Accreditation Statement:. The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.. The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their ...
The term scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin) and it is used to describe a disease characterized by progressive skin hardening and induration. Hippocrates first described this condition as thickened skin.
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A 59-year-old man with limited cutaneous systemic sclerosis (lcSSc), who had retired after many years as a construction worker, presented with bilateral knee deformity without discomfort or pain. A diagnosis of lcSSc had been made 13 years previously on the basis of sclerodactyly, digital ulceration, calcinosis, and positive anticentromere antibodies. Treatment by ilomedine was initiated in 1999 … ...
Raynauds disease, syndrome or phenomenon, whether primary or secondary, is characterized by extreme coldness in the hands or feet, the fingers or toes becoming white and numb. The color may change to blue and finally red, as the blood returns to the tissues. This can take from several minutes to many hours, and can be extremely painful. It may also affect the ears and nose.. Why Raynauds phenomenon occurs is not well understood. Usually, the body conserves heat by reducing blood circulation to the extremities, particularly the hands and feet. This response uses a complex system of nerves and muscles to control blood flow through the smallest blood vessels in the skin. In people with Raynauds phenomenon, this control system becomes too sensitive to cold and greatly reduces blood flow in the fingers. Damage to either the muscles or nerves that control blood flow may be the cause of Raynauds phenomenon.. Treatment may vary according to the severity of the symptoms. In mild cases it may be ...
Pemphigus foliaceus, calcinosis cutis and hepatocutaneous syndrome are the 3 strange and unusual skin diseases that can plague pets.
Sildenafil, a specific inhibitor of phosphodiesterase 5A (PDE5A), is currently tested as a treatment for severe Raynaud's phenomenon. Here, we tested
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Sigma-Aldrich offers abstracts and full-text articles by [T Ojasoo, E Bignon, A Crastes de Paulet, J C Doré, J Gilbert, J F Miquel, M Pons, J P Raynaud].
Gro72] Groupes de monodromie en géométrie algébrique. I, Lecture Notes in Mathematics, Vol. 288, Springer-Verlag, Berlin-New York, 1972 (French). Séminaire de Géométrie Algébrique du Bois-Marie 1967-1969 (SGA 7 I); Dirigé par A. Grothendieck. Avec la collaboration de M. Raynaud et D. S. Rim. MR 0354656 ...
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List of 23 causes of Energy symptoms and Fever and Raynauds phenomenon, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Learn more about Raynauds Phenomenon at Doctors Hospital of Augusta Uses Principal Proposed Natural Treatments None Other Proposed Natural Treatments ...
A-D: Phospho-CREB-positive cells are increased after beraprost treatment. (7A and 7C). Representative images of brain sections show p-CREB immunostaining in Y
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Scleroderma (especially CREST syndrome). Mixed connective tissue disease Systemic lupus erythematosus Rheumatoid arthritis Dermatomyositis. Which occurs more frequently, primary or secondary pulmonary hypertension?. Primary (unexplained) pulmonary hypertension is a rare disorder. Secondary pulmonary hypertension is seen considerably more often in practice.. What population group is most frequently affected by primary pulmonary hypertension?. Although primary pulmonary hypertension occurs in both sexes and virtually all age groups, it has a tendency to affect young females. The female-to-male predominance is 1.7:1, and the mean age is 36 years.. Is surgical therapy now an option for patients with pulmonary hypertension secondary to chronic recurrent thromboembolism?. Appropriate prevention of recurrent thromboembolism continues to be extremely important. In addition to this prevention, it is now possible to remove organized thrombus surgically from the proximal pulmonary arteries of patients with ...
St. Marys College of Maryland (SMCM) anthropology students Melody Raynaud and Daniel Mehaffey have been selected as inaugural Undergraduate Research Fellows for the American Anthropological Association. Raynaud and Mehaffey are two of only six fellows selected from a nationwide pool of applicants that received the fellowship. Since receiving the fellowship from the American Anthropological Association, a first-year student, Colette Nortman, has joined the team in order to gain first hand ethnographic research experience.. Funded by the Center for Research on College-Workforce Transitions of the Wisconsin Center for Education Research at the University of Wisconsin, Madison, this program supports research projects that use ethnographic or mixed methods to address the question, how do anthropology majors prepare for life after college?. With mentor and professor of anthropology William Roberts, Raynaud and Mehaffey will focus their research on answering questions regarding students experiences ...
The condition can cause pain within the affected extremities, discoloration (paleness), and sensations of cold and/or numbness. This can often be distressing to those who are undiagnosed, and sometimes it can be obstructive. If someone with Raynauds is placed into a cold climate, it could potentially become dangerous. When exposed to cold temperatures, the blood supply to the fingers or toes, and in some cases the nose or earlobes, is markedly reduced; the skin turns pale or white (called pallor) and becomes cold and numb. These events are episodic, and when the episode subsides or the area is warmed, the blood flow returns, and the skin color first turns red (rubor), and then back to normal, often accompanied by swelling, tingling, and a painful "pins and needles" sensation. All three color changes are observed in classic Raynauds. However, not all patients see all of the aforementioned color changes in all episodes, especially in milder cases of the condition. Symptoms are thought to be due ...
List of 89 disease causes of Raynauds phenomenon, patient stories, diagnostic guides, 10 drug side effect causes. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Raynauds phenomenon.
Raynaud's syndrome is a common in fibromyalgia and chronic fatigue syndrome. Learn about this cause of extremely cold hands and feet.
Leclaire, S., Merkling, T., Raynaud, C., Giacinti, G., Bessière, J. - M., Hatch, S. A., & Danchin, E. (2011). An individual and a sex odor signature in kittiwakes? Study of the semiochemical composition of preen secretion and preen down feathers. Naturwissenschaften, 98, 615-624. Retrieved from file:///C:/Danchin/Biblio/Articles%20PDF/Leclaire%20et%20al%20Naturwissenschaften%202011. ...
List of 20 causes of Fever and Raynauds phenomenon and Toe symptoms, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Raynauds phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. This happens due to spasms of blood vessels in those areas. The spasms happen in response to cold, stress, or emotional upset.
Raynauds phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. This happens due to spasms of blood vessels in those areas. The spasms happen in response to cold, stress, or emotional upset.
Raynauds phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. This happens due to spasms of blood vessels in those areas. The spasms happen in response to cold, stress, or emotional upset.
Raynauds phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. This happens due to spasms of blood vessels in those areas. The spasms happen in response to cold, stress, or emotional upset.
What is a risk factor? A risk factor is anything that may increase a persons chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases have different risk factors.. Although these factors can increase a persons risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop a disease, while others develop the disease and have no known risk factors.. But, knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.. ...
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Dear Editor,. Congratulations Canadian Family Physician and Dr Ran D. Goldman for the Child Health Update on Raynauds phenomenon (RP) [1]. I would like to point to a new study in childhood on this underrated functional vascular disease.. The pediatric research group of Gorski et al from Poland examined with the help of nail fold capillaroscopy and blood tests 66 patients with RG (34 undifferentiated RP and 32 secondary RP) aged 6-19 years and a control group with 20 healthy children [2]. Compared to the control group, significantly higher concentrations of endothelin-1 (p = 0.0134), sE-selectin and high-sensitivity C-reactive protein (hsCRP: p , 0.001) were found in the patients with RG, as well as a lower high-density lipoprotein cholesterol concentration in the lipid profile (p = 0.001). The group over 15 years also had higher levels of low-density lipoprotein fraction and triglyceride. As the analysis of multiple linear regression showed, among the capillaroscopic parameters, the more ...
Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Angel González-Gay, Natalia Palmou-Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas-Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther F. Vicente, Santos Castañeda, Albert Selva-OCallaghan, Ernesto Trallero Araguas, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, Nikolaus Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Juan Carlos Nieto-González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, Rossella Neri, Marta Mosca, Marzia Caproni, Julia Weinmann-Menke, Andreas Schwarting, Vanessa Smith, Maurizio Cutolo and The American and European Network of Antisynthetase Syndrome Collaborative Group ...
Authors: NEVZAT GÖZEL, AHMET KARATAŞ, MELTEM YARDIM, MESUDE SEDA AYDOĞDU, RAMAZAN ULU, FATİH DEMİRCAN, FARUK KILINÇ, BURAK ÖZ, EMİR DÖNDER, SÜLEYMAN AYDIN, SÜLEYMAN SERDAR KOCA Abstract: Background/aim: The pathogenesis of Raynauds phenomenon (RP) has not yet been fully elucidated. RP is characterized by exaggerated cold-induced vasoconstriction. Urotensin II (UII) is a potent vasoconstrictor. The aim of the present study was to evaluate plasma UII levels in both primary RP and secondary RP associated with systemic sclerosis (SSc).Materials and methods: Fifteen patients with primary RP, 30 patients with RP secondary to SSc, and 30 healthy controls (HC) were included in the study. Raynaud condition scores (RCS) were determined in the primary RP and SSc groups. Modified Rodnan skin score (MRSS) was determined for the SSc patients. Plasma UII level was analyzed by the ELISA method. Results: When compared to the HC group, plasma UII level was lower in the secondary RP group, but not in ...
If you have any of the following conditions you should not take imitrex: allergy to Imitrex, Raynaud syndrome, strokes in the past, certain types of heart disease, transient ischemic attacks, uncontrolled blood pressure, peripheral vascular disease. You should consult your personal doctor before taking this medicine if you smoke, have high cholesterole or high blood pressure, diabetes ...
This test is done to find out if you have abnormal proteins in your blood. They can be a sign of rheumatoid arthritis, lupus, or Raynaud syndrome, among other illnesses.
Hu, H.; Haas, S. A.; Chelly, J.; Van Esch, H.; Raynaud, M.; de Brouwer, A. P. M.; Weinert, S.; Froyen, G.; Frints, S. G. M.; Laumonnier, F. et al.; Zemojtel, T.; Love, M. I.; Richard, H.; Emde, A.-K.; Bienek, M.; Jensen, C.; Hambrock, M.; Fischer, U.; Langnick, C.; Feldkamp, M.; Wissink-Lindhout, W.; Lebrun, N.; Castelnau, L.; Rucci, J.; Montjean, R.; Dorseuil, O.; Billuart, P.; Stuhlmann, T.; Shaw, M.; Corbett, M. A.; Gardner, A.; Willis-Owen, S.; Tan, C.; Friend, K. L.; Belet, S.; van Roozendaal, K. E. P.; Jimenez-Pocquet, M.; Moizard, M.-P.; Ronce, N.; Sun, R.; OKeeffe, S.; Chenna, R.; van Bömmel, A.; Göke, J.; Hackett, A.; Field, M.; Christie, L.; Boyle, J.; Haan, E.; Nelson, J.; Turner, G.; Baynam, G.; Gillessen-Kaesbach, G.; Müller, U.; Steinberger, D.; Budny, B.; Badura-Stronka, M.; Latos-Bieleńska, A.; Ousager, L. B.; Wieacker, P.; Rodríguez Criado, G.; Bondeson, M.-L.; Annerén, G.; Dufke, A.; Cohen, M.; Van Maldergem, L.; Vincent-Delorme, C.; Echenne, B.; Simon-Bouy, B.; ...
Vera M. Kalscheuer, Z. Iqbal, H. Hu, S.A. Haas, M. Shaw, N. Lebrun, E. Seemanova, K. Voesenek, L. Hobson, H.H. Ropers, S. Townshend, M. Raynaud, H. van Bokhoven, S. Riazuddin, J. Chelly, J. ...
calcinosis from radiesse. Scleroderma - Dermatologist in Honolulu, HI. You can give yourself fuller lips instantly with the Lip Plumper. Give yourself fuller lips instantly as Idol Lips
List of 83 causes for Gerd-like chest pain and Raynauds phenomenon and Severe heartburn after eating, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Raynauds Phenomenon affects the circulation mainly in the hands and feet. Blood vessels may shrink when hands are exposed to the cold and spasms may occur. At times, fingers and toes may turn white and blue from a lack of oxygen.
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Scleroderma would usually start of in the skin in the form of calcinosis or Raynauds phenomenon. If it sticks with those symptoms, then that case of scleroderma is most likely limited scleroderma or CREST which is the milder form of the illness. Although this can disable, it would tend most of the time not to be fatal. However, if it spreads to the internal organs, the kidneys in particular, then that would be the beginning of scleroderma renal involvement ...
Summary: The patients work-up included pulmonary function tests, which revealed a reduction in vital capacity and a decreased lung compliance. The results ...
RP is classified into two categories: primary and secondary. Primary RP are vasospastic attacks precipitated by cold temperatures or emotional stress. Primary RP, which occurs in the absence of an identifiable disease, is most common in otherwise healthy females between 15 and 30 years of age. A family history of first-degree family members is reported in about 30% of cases. These attacks usually occur symmetrically and bilaterally in the hands. There is no underlying sign of tissue necrosis or gangrene (eg, digital pitting) and the underlying vasculature is normal. Nailfold capillary microscopy (see below) and physical examination findings are normal. If a patient meets criteria for primary RP and no new symptoms develop over 2 years of follow-up, the development of secondary disease is unlikely. The finding of abnormal nailfold capillaries on microscopy or specific autoantibodies are strong predictors of secondary RP due to an underlying rheumatologic disease. ...
Objectives-To evaluate the impact of extremely low frequency ELF magnetic fields on markers of human fertility. Methods-A follow up study of time to pregnancy, semen quality, and reproductive hormones was conducted among couples planning first pregnancies 36 males were welders and 21 were non-welders. The male and the female partner were...
A novel exposure system for double-blind human electromagnetic provocation studies has been developed that satisfies the precision, control of fields and potential artifacts, and provides the flexibility to investigate the response of hypotheses-driven electromagnetic field exposure schemes on brain function, ranging from extremely low frequency (ELF) to radio frequency (RF) fields. The system can provide the same exposure of the lateral cerebral cortex at two different RF frequencies (900 and 2140 MHz) but with different exposure levels at subcortical structures, and also allows uniform ELF magnetic field exposure of the brain. The RF modulation and ELF signal are obtained by a freely programmable arbitrary signal generator allowing a wide range of worst-case exposure scenarios to be simulated, including those caused by wireless devices. The maximum achievable RF exposure is larger than 60 W/kg peak spatial specific absorption rate averaged over 10 g of tissue. The maximum ELF magnetic field ...

What is Horner syndrome? | Reference.comWhat is Horner syndrome? | Reference.com

Horner syndrome is a nerve disorder in which the nerve pathway on one side of the face is disrupted, causing a drooping eyelid ... What is CREST syndrome?. A: CREST syndrome is a skin condition that causes hardened skin on the lower arms, legs, face and ... What is DiGeorge syndrome?. A: DiGeorge syndrome is a genetic condition that affects chromosome 22, states Mayo Clinic. This ... Horner syndrome is a nerve disorder in which the nerve pathway on one side of the face is disrupted, causing a drooping eyelid ...
more infohttps://www.reference.com/health/horner-syndrome-a9f3bcce22da2b37

CREST syndrome: MedlinePlus Medical Encyclopedia ImageCREST syndrome: MedlinePlus Medical Encyclopedia Image

CREST is an acronym for the clinical features that are seen in a patient ... The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis, scleroderma ... Usually only 2 of the 5 symptoms of the CREST syndrome is necessary to be diagnosed with the disease. ... The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis (scleroderma ...
more infohttps://medlineplus.gov/ency/imagepages/19507.htm

Crest syndrome | Define Crest syndrome at Dictionary.comCrest syndrome | Define Crest syndrome at Dictionary.com

Crest syndrome definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up ...
more infohttps://www.dictionary.com/browse/crest-syndrome

What is CREST Syndrome?What is CREST Syndrome?

CREST is a form of Systemic Sclerosis (scleroderma) which is characterized by Calcinosis (calcium deposits), Raynauds, ... Overview: What is CREST?. "Pure" CREST. "Plus" CREST. Progression. CREST Antibodies. CREST Overlaps. Treatments. CREST Patient ... CREST Syndrome. "Patients with CREST syndrome are a subset of patients with scleroderma…" Medscape. ... "Pure" CREST. "Pure"CREST - by itself: "Pure" CREST is diagnosed when patients have two or more symptoms of CREST but they do ...
more infohttps://www.sclero.org/scleroderma/types/systemic/limited/crest/a-to-z.html

CREST syndrome - WikipediaCREST syndrome - Wikipedia

CREST syndrome can be noted in up to 10% of patients with primary biliary cirrhosis. The combination of symptoms was first ... CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue ... Other symptoms of CREST syndrome can be exhaustion, weakness, difficulties with breathing, pain in hands and feet, dizziness ... Crest syndrome involves the production of autoimmune anti-nuclear and anti-centromere antibodies, though their cause is not ...
more infohttps://en.wikipedia.org/wiki/CREST_syndrome

LearningRadiology - CREST SyndromeLearningRadiology - CREST Syndrome

An award-winning, radiologic teaching site for medical students and those starting out in radiology focusing on chest, GI, cardiac and musculoskeletal diseases containing hundreds of lectures, quizzes, hand-out notes, interactive material, most commons lists and pictorial differential diagnoses
more infohttp://learningradiology.com/notes/bonenotes/crstpage.htm

Jays Story: Scleroderma and CREST SyndromeJay's Story: Scleroderma and CREST Syndrome

My name is Jay and I have scleroderma with CREST syndrome. I have calcium deposits, Raynauds, thyroid problems, heartburn, and ... CREST Syndrome. Calcinosis. Difficulty Swallowing (Dysphagia). Heartburn (Reflux). Raynauds. Skin Tightening (Sclerodactyly). ... I remember saying, "What? Like toothpaste?" I had CREST or at least the CR of CREST. If I only had known what the future had in ... So ended the (C) in Crest Syndrome and now on to (R) Raynauds. ... Jay: Scleroderma and CREST. The pain was so intense that tears ...
more infohttps://www.sclero.org/scleroderma/support/stories/english/h-i-j/jay/a-to-z.html

CRST Syndrome. | Annals of Internal Medicine | American College of PhysiciansCRST Syndrome. | Annals of Internal Medicine | American College of Physicians

Comparison of the CRST syndrome with the common acrosclerotic type of scleroderma is made, revealing several common features ... The CRST syndrome is a recently defined symptom-complex consisting of (1) calcinosis cutis, (2) Raynauds phenomenon, (3) ... CRST Syndrome. Richard D. Carr, M.D.; Eldred B. Heisel, M.D. ... The CRST syndrome does appear to pursue a prolonged and more ... CRST Syndrome.. Ann Intern Med. 1966;64:1174. doi: 10.7326/0003-4819-64-5-1174_2 ...
more infohttps://annals.org/aim/article-abstract/680753/crst-syndrome

CREST syndrome | Radiology Reference Article | Radiopaedia.orgCREST syndrome | Radiology Reference Article | Radiopaedia.org

CREST syndrome is a variant of progressive systemic sclerosis (PSS) and stands for C - Calcinosis R - Raynaud phenomenon E - ... CREST syndrome. Dr Henry Knipe ◉ ◈ and A.Prof Frank Gaillard ◉ ◈ et al. ... CREST syndrome is a variant of progressive systemic sclerosis (PSS) and stands for ... Disproportionately severe calcinosis cutis in an 88-year-old patient with CREST syndrome. Skeletal Radiol. 2001;30 (8): 478-81 ...
more infohttps://radiopaedia.org/articles/crest-syndrome

Limited cutaneous systemic sclerosis (Scleroderma, CREST syndrome) - ONALimited cutaneous systemic sclerosis (Scleroderma, CREST syndrome) - ONA

... previously CREST syndrome, standing for calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, ... Overlap syndromes present particular diagnostic challenges. Patients with polymyositis/systemic sclerosis overlap have been ... described with the typical features of systemic sclerosis in addition to polymyositis, dermatomyositis, and Sjogrens syndrome ...
more infohttp://www.oncologynurseadvisor.com/dermatology/limited-cutaneous-systemic-sclerosis-scleroderma-crest-syndrome/article/594372/

Barretts Esophageal Adenocarcinoma with CREST Syndrome | springermedizin.deBarrett's Esophageal Adenocarcinoma with CREST Syndrome | springermedizin.de

Barretts Esophageal Adenocarcinoma with CREST Syndrome. Zeitschrift:. Esophagus > Ausgabe 3/2017 Autoren:. Tomohiro Kunishige ... Clinical, serological and genetic study in patients with CREST syndrome. Intern Med. 2000;39:451-6. CrossRefPubMed ... Barretts Esophageal Adenocarcinoma with CREST Syndrome Autoren:. Tomohiro Kunishige Sohei Matsumoto Kohei Wakatsuki Kazuhiro ... The patient was diagnosed with Barretts adenocarcinoma and CREST syndrome, which is a form of scleroderma. Subtotal ...
more infohttps://www.springermedizin.de/barrett-s-esophageal-adenocarcinoma-with-crest-syndrome/11954624

CREST syndrome | Pathology StudentCREST syndrome | Pathology Student

CREST syndrome is one expression of a larger disease known as systemic sclerosis (or, if youre stuck in your ways like me, ... CREST syndrome is one expression of a larger disease known as systemic sclerosis (or, if youre stuck in your ways like me, ... CREST syndrome is one expression of a larger disease known as systemic sclerosis (or, if youre stuck in your ways like me, " ... CREST syndrome. Sep 21, 2014 , Cardiac pathology, Pulmonary pathology, Renal pathology, Skin pathology ...
more infohttp://www.pathologystudent.com/crest-syndrome/

Limited cutaneous systemic sclerosis (Scleroderma, CREST syndrome) - Cancer Therapy AdvisorLimited cutaneous systemic sclerosis (Scleroderma, CREST syndrome) - Cancer Therapy Advisor

... previously CREST syndrome, standing for calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, ... Overlap syndromes present particular diagnostic challenges. Patients with polymyositis/systemic sclerosis overlap have been ... described with the typical features of systemic sclerosis in addition to polymyositis, dermatomyositis, and Sjogrens syndrome ...
more infohttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/dermatology/limited-cutaneous-systemic-sclerosis-scleroderma-crest-syndrome/

Scleroderma and CREST syndrome | Deranged PhysiologyScleroderma and CREST syndrome | Deranged Physiology

Question 8 from the second paper of 2003 was more interested in CREST syndrome. Generally, the topic of mixed connective tissue ... Question 8 from the second paper of 2003 was more interested in CREST syndrome. Generally, the topic of mixed connective tissue ... It may manifest either as a diffuse systemic disease (diffuse cutaneous systemic sclerosis) or as the limited CREST syndrome ... The rapidly fatal scleroderma-pulmonary-renal syndrome (SPRS) may develop, which manifests as a fulminant course of acute ...
more infohttps://derangedphysiology.com/main/required-reading/miscellaneous-topics/Chapter%203.0.2/scleroderma-and-crest-syndrome

Systemic Sclerosis (CREST syndrome) Article - StatPearlsSystemic Sclerosis (CREST syndrome) Article - StatPearls

CREST syndrome). LcSSc is also known as morphea.. Diffuse Systemic Sclerosis is distinguished from the localized variant (CREST ... Systemic Sclerosis (CREST syndrome). Introduction. Systemic sclerosis, otherwise known as Scleroderma, is a rare connective ... This is more pronounced for CREST syndrome, with a female to male ratio of 10:1. The diffuse variant is more evenly distributed ... Limited Scleroderma (CREST) syndrome. The clinical features and disease progression are more insidious. Limited scleroderma ( ...
more infohttps://statpearls.com/as/connective%20tissue/20112/

Crest Syndrome ThrombocytopeniaCrest Syndrome Thrombocytopenia

... My thrombocytopenia, Online resources for thrombocytopenia. ... Crest Syndrome Thrombocytopenia. The study showed that it truly is not just the surge of estrogen on a regular period it is ... It is crest syndrome thrombocytopenia important flavonoids in the bloodstream it can do for you. To give you and feel the power ... Rid your body clear fat and was routines specifically on the face headache myogenic headache crest syndrome thrombocytopenia ...
more infohttp://mythrombocytopenia.net/crest-syndrome-thrombocytopenia/

RheumaKnowledgy » CREST SyndromeRheumaKnowledgy » CREST Syndrome

Definition: "CREST syndrome" is more appropriately referred to as "limited scleroderma." In this variant of systemic sclerosis ... Those with longstanding CREST syndrome are at greatest risk for developing progressive pulmonary hypertension, usually late in ... Uncommon Findings: Small bowel disease is infrequently encountered in those with longstanding CREST syndrome and may manifest ... Clinical and serological comparison of 17 chronic progressive systemic sclerosis (PSS) and 17 CREST syndrome patients matched ...
more infohttp://www.rheumaknowledgy.com/crest-syndrome/

CREST Syndrome Disease - CatchMyPain CommunityCREST Syndrome Disease - CatchMyPain Community

I had to look up CREST Syndrome. I dont have it, but I do have some of the symptoms of it. I have hEDS. I have the Raynauds ... Auto I do not have CREST either but I have Polymyalgia Rhuematica and Myositis which I had not heard of until I was diagnosis. ... What is CREST? Care to enlighten those of us who have never heard of it? ... Im so sorry you going thru a disease that doesnt have enough info just like Sjögrens syndrome and fibromyalgia. ...
more infohttp://community.catchmypain.com/topic/crest-syndrome-disease.html

Skin Diseases Information Center: Acne Vulgaris, CREST Syndrome, Acrodermatitis SyndromeSkin Diseases Information Center: Acne Vulgaris, CREST Syndrome, Acrodermatitis Syndrome

Acrodermatitis Syndrome, Crest Syndrome, Cutis Laxa, Fifths Disease, Hirsutism, Ichthyosis Vulgaris, Hyperhidrosis, Melanoma, ...
more infohttps://www.epainassist.com/skin/10

Skin Diseases Information Center: Acne Vulgaris, CREST Syndrome, Acrodermatitis SyndromeSkin Diseases Information Center: Acne Vulgaris, CREST Syndrome, Acrodermatitis Syndrome

Acrodermatitis Syndrome, Crest Syndrome, Cutis Laxa, Fifths Disease, Hirsutism, Ichthyosis Vulgaris, Hyperhidrosis, Melanoma, ...
more infohttps://www.epainassist.com/skin

scleroderma crest syndromescleroderma crest syndrome

... scleroderma crest syndrome, Scleroderma cure, Scleroderma definition, Scleroderma disease, Scleroderma disorder, Scleroderma ... scleroderma crest syndrome, Scleroderma cure, Scleroderma definition, Scleroderma disease, Scleroderma disorder, Scleroderma ... scleroderma crest syndrome, scleroderma diagnosis, scleroderma foundation, scleroderma life expectancy, scleroderma pictures, ...
more infohttps://www.herbal-care-products.com/blog/tag/scleroderma-crest-syndrome/

Limited scleroderma (CREST syndrome) - ORGENTEC Autoimmunity BlogLimited scleroderma (CREST syndrome) - ORGENTEC Autoimmunity Blog

Limited scleroderma (CREST syndrome). Limited scleroderma, or: CREST syndrome, is one subtype of the heterogeneous group of ... CREST syndrome is believed to be an autoimmune disease. Its name is an acronym for the common clinical features of the syndrome ... New ACR and EULAR Approved Classification Criteria for Primary Sjoegrens Syndrome * Future perspectives for diagnostics of ...
more infohttp://autoimmunityblog.com/list-of-autoimmune-diseases/from-f-to-p/limited-scleroderma-crest-syndrome/

AboutBFS.com • View topic - Crest syndrome/ sclerodermaAboutBFS.com • View topic - Crest syndrome/ scleroderma

Re: Crest syndrome/ scleroderma. by Yuliasir on November 10th, 2015, 1:07 am ... Re: Crest syndrome/ scleroderma. by Tb12 on November 10th, 2015, 1:52 am ... Re: Crest syndrome/ scleroderma. by leroyb on November 10th, 2015, 7:10 am ... Re: Crest syndrome/ scleroderma. by Yuliasir on November 10th, 2015, 8:38 am ...
more infohttp://www.aboutbfs.com/forums/viewtopic.php?p=163515

Crest Syndrome Symptoms, Diagnosis & Treatment Options | MedicalAdvicePlus.comCrest Syndrome Symptoms, Diagnosis & Treatment Options | MedicalAdvicePlus.com

Crest syndrome is an acronym for Calcinosis; Reynaudssyndrome; Esophagealdysmotility; Sclerodactyly and Telangiectasia. It is ... Crest Syndrome Symptoms, Diagnosis & Treatment Options. Crest syndrome is an acronym for Calcinosis; Reynaudssyndrome; ... CREST syndrome can be difficult to diagnose because its symptoms vary widely and often resemble those of other connective ... It is believed that CREST syndrome is an autoimmune disorder, in which the immune system of ones body turns against its own. ...
more infohttp://medicaladviceplus.com/crest-syndrome-symptoms-diagnosis-treatment-options/

Iliolumbar ligament injury | Iliolumbar Syndrome | Iliac crest pain syndrome - Caring MedicalIliolumbar ligament injury | Iliolumbar Syndrome | Iliac crest pain syndrome - Caring Medical

... also known as iliac crest pain syndrome, involves an inflammation or tear of the iliolumbar ligament. This ligament extends ... from the spine to the iliac crest, which is the back of the pelvis. It can lead to referred pain in the groin, the pelvis, the ... Iliolumbar ligament injury , Iliolumbar Syndrome , Iliac crest pain syndrome. Ross Hauser, MD , Caring Medical Regenerative ... Clues during the examination you may have Iliolumbar ligament injury , Iliolumbar Syndrome , Iliac crest pain syndrome. In the ...
more infohttps://www.caringmedical.com/prolotherapy-news/iliolumbar-syndrome-iliac-crest-pain-syndrome/
  • Primary biliary cirrhosis accompanied by CREST syndrome. (sclero.org)
  • Granulomatous uveitis, CREST syndrome, and primary biliary cirrhosis. (sclero.org)
  • CREST syndrome can be noted in up to 10% of patients with primary biliary cirrhosis. (wikipedia.org)
  • We report the case of a 70-year old woman with primary biliary cirrhosis, CREST syndrome and vascular gastric lesions corresponding to watermelon stomach. (uclouvain.be)
  • Auto I do not have CREST either but I have Polymyalgia Rhuematica and Myositis which I had not heard of until I was diagnosis. (catchmypain.com)
  • I just told him about my swallowing issues, joint pain, muscle stiffness and now he has me going on a goose chase for crest syndrome blood tests and I just researched the auto immune disease and it's not a good diagnosis. (aboutbfs.com)
  • Although some doctors still believe CREST is a useful subcategory, the existing research studies have been unable to predict consistently how (or whether) the disease will progress to Diffuse Systemic Scleroderma in any specific individual. (sclero.org)
  • They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target) is a type of anti-nuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. (wikipedia.org)
  • But in this case it usually quite clear in terms of physical changes in the hand appearance, low mobility in joints, quite strong Raynaud syndrome (many of us have it becasue of generally bad microcirculation), calcinosis (formation of hard underscim calcium salts deposits under the skin), cracking skin etc. (aboutbfs.com)
  • CREST syndrome , also known as limited scleroderma, is a widespread connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs . (cdc.gov)
  • The immune system in people with CREST syndrome appears to stimulate cells called fibroblasts to produce excess amounts of collagen. (cdc.gov)
  • Thickening generally only involves the skin of the fingers distal to the metacarpophalangeal joints in CREST. (wikipedia.org)
  • Small bowel disease is infrequently encountered in those with longstanding CREST syndrome and may manifest as bloating, cramping, diarrhea, or malabsorption. (rheumaknowledgy.com)
  • I'm so sorry you going thru a disease that doesn't have enough info just like Sjögren's syndrome and fibromyalgia. (catchmypain.com)